External Ids for FMN2 Gene
This gene is a member of the formin homology protein family. The encoded protein is thought to have essential roles in organization of the actin cytoskeleton and in cell polarity. Mutations in this gene have been associated with mental retardation autosomal recessive 47 (MRT47). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
GeneCards Summary for FMN2 Gene
FMN2 (Formin 2) is a Protein Coding gene. Diseases associated with FMN2 include mental retardation, autosomal recessive 47 and autosomal recessive non-syndromic intellectual disability. Among its related pathways are Dorso-ventral axis formation. GO annotations related to this gene include actin binding. An important paralog of this gene is DIAPH3.
UniProtKB/Swiss-Prot for FMN2 Gene
Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization. Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest. Protects cells against apoptosis by protecting CDKN1A against degradation.