Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FMN1 Gene

protein-coding   GIFtS: 52
GCID: GC15M033059

Formin 1

(Previous name: formin (limb deformity))
(Previous symbols: LD, FMN)
  See FMN1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Formin 11 2     Limb Deformity Protein Homolog2 3
FMN1 2 3 5     Limb Deformity Protein1
LD1 2 3 5     formin-12
Formin (Limb Deformity)1 2     

External Ids:    HGNC: 37681   Entrez Gene: 3421842   Ensembl: ENSG000002489057   OMIM: 1365355   UniProtKB: Q68DA73   

Export aliases for FMN1 gene to outside databases

Previous GC identifers: GC15M030854 GC15M033066 GC15M009919


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for FMN1 Gene:
FMN1 (formin 1) is a protein-coding gene. Diseases associated with FMN1 include renal hypoplasia. GO annotations related to this gene include actin binding and SH3 domain binding. An important paralog of this gene is DAAM1.

UniProtKB/Swiss-Prot: FMN1_HUMAN, Q68DA7
Function: Plays a role in the formation of adherens junction and the polymerization of linear actin cables (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  NT_187660.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the FMN1 gene promoter:
         TBP   AP-1   TFIID   STAT3   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FMN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FMN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q13.3   Ensembl cytogenetic band:  15q13.3   HGNC cytogenetic band: 15q13.3

FMN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FMN1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M033059:  view genomic region     (about GC identifiers)

Start:
33,057,747 bp from pter      End:
33,486,897 bp from pter
Size:
429,151 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FMN1_HUMAN, Q68DA7 (See protein sequence)
Recommended Name: Formin-1  
Size: 1419 amino acids; 157578 Da
Subunit: Interacts with alpha-catenin and may interact with tubulin (By similarity)
Developmental stage: Expressed in fetal kidney and fetal lung
Secondary accessions: Q3B7I6 Q3ZAR4 Q6ZSY1
Alternative splicing: 4 isoforms:  Q68DA7-1   Q68DA7-2   Q68DA7-3   Q68DA7-5   (Ref.3 (AAI03693/AAI07594) sequences are in conflict in position: 171:G->V. Ref.3 (AAI07594) sequence is in conflict in position: 239:G->E)

Explore the universe of human proteins at neXtProt for FMN1: NX_Q68DA7

Explore proteomics data for FMN1 at MOPED

Post-translational modifications: 

  • Phosphorylated on serine and possibly threonine residues (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FMN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001096654.1  NP_001264242.1  NP_001264243.1  

    ENSEMBL proteins: 
     ENSP00000333950   ENSP00000453443   ENSP00000454047   ENSP00000453110   ENSP00000453266  
     ENSP00000453682   ENSP00000452984   ENSP00000325166  

    FMN1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FMN1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for FMN1
    GenScript Custom Purified and Recombinant Proteins Services for FMN1
    Novus Biologicals FMN1 Proteins
    Novus Biologicals FMN1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FMN1

     
    Search eBioscience for Proteins for FMN1 

    FMN1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for FMN1
    OriGene Custom Antibody Services for FMN1
    Novus Biologicals FMN1 Antibodies
    Abcam antibodies for FMN1
    Cloud-Clone Corp. Antibodies for FMN1
    Search ThermoFisher Antibodies for FMN1
    Search LSBio for Antibodies for FMN1

    FMN1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FMN1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FMN1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FMN1
    Cloud-Clone Corp. CLIAs for FMN1
    Search eBioscience for ELISAs for FMN1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR015425 FH2_Formin
     IPR001265 Formin_Cappuccino_subfam

    Graphical View of Domain Structure for InterPro Entry Q68DA7

    ProtoNet protein and cluster: Q68DA7

    UniProtKB/Swiss-Prot: FMN1_HUMAN, Q68DA7
    Similarity: Belongs to the formin homology family. Cappuccino subfamily
    Similarity: Contains 1 FH1 (formin homology 1) domain
    Similarity: Contains 1 FH2 (formin homology 2) domain


    Find genes that share domains with FMN1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FMN1_HUMAN, Q68DA7
    Function: Plays a role in the formation of adherens junction and the polymerization of linear actin cables (By
    similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003779actin binding IEA--
    GO:0005515protein binding ----
    GO:0017124SH3 domain binding IEA--
         
    Find genes that share ontologies with FMN1           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for FMN1:
     Big cells  Increased focal adhesion (FA)   Stronger migration  Synthetic lethal with Ras 

         10 MGI mutant phenotypes (inferred from 12 alleles(MGI details for Fmn1):
     cellular  integument  limbs/digits/tail  mortality/aging  no phenotypic analysis 
     normal  pigmentation  renal/urinary system  reproductive system  skeleton 

    Find genes that share phenotypes with FMN1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FMN1: Fmn1tm1.1Zlr Fmn1tm1Zlr Fmn1tm2Led Fmn1tm1Led Fmn1tm1Awb

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FMN1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FMN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FMN1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FMN1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat FMN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FMN1 (see all 58):
    hsa-miR-579 hsa-miR-218-1* hsa-miR-29a hsa-miR-3167 hsa-miR-3613-3p hsa-miR-3116 hsa-miR-330-3p hsa-miR-4326
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FMN1
    Predesigned siRNA for gene silencing in human, mouse, rat FMN1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FMN1

    Clone
    Products:
         
    OriGene clones in human, mouse for FMN1 (see all 6)
    OriGene ORF clones in mouse, rat for FMN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FMN1 (NM_001103184)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FMN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FMN1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FMN1
    Browse ESI BIO Cell Lines and PureStem Progenitors for FMN1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMN1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FMN1_HUMAN, Q68DA7: Nucleus (By similarity). Cytoplasm (By similarity). Cell junction, adherens junction (By
    similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Localization to
    the adherens junctions is alpha-catenin-dependent. Also localizes to F-actin bundles originating from adherens
    junctions and to microtubules (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton3
    cytosol2
    nucleus2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005884actin filament IEA--
    GO:0005886plasma membrane IEA--
    GO:0005912adherens junction IEA--

    Find genes that share ontologies with FMN1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FMN1 About    
    See pathways by source

    SuperPathContained pathways About
    1E-cadherin signaling in keratinocytes
    E-cadherin signaling in keratinocytes
    2Cell adhesion Cadherin mediated cell adhesion
    Cell adhesion Cadherin mediated cell adhesion

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for FMN1
        Cell adhesion Cadherin-mediated cell adhesion

    1 BioSystems Pathway for FMN1
        E-cadherin signaling in keratinocytes


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FMN1
    Interactions:

        GeneGlobe Interaction Network for FMN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FMN1 (Q68DA73 ENSP000003339504) via UniProtKB, MINT, STRING, and/or I2D (see all 145)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FNBP4Q8N3X13, ENSP000002637734I2D: score=1 STRING: ENSP00000263773
    PRPF40AO754003I2D: score=2 
    FNBP1Q96RU33I2D: score=1 
    SRGAP2O750443I2D: score=1 
    CTNNA1ENSP000003046694STRING: ENSP00000304669
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010467gene expression IEA--
    GO:0030838positive regulation of actin filament polymerization ----
    GO:0035136forelimb morphogenesis IEA--
    GO:0035137hindlimb morphogenesis IEA--
    GO:0045010actin nucleation IEA--

    Find genes that share ontologies with FMN1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FMN1

    9 Novoseek inferred chemical compound relationships for FMN1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mdi-a 95 9 19457867 (2), 17855386 (1), 18239683 (1), 16361707 (1) (see all 8)
    spir 62.9 3 19605360 (1), 16901698 (1), 15053972 (1)
    actomyosin 52.9 1 16487696 (1)
    atp 6.63 4 20192778 (1), 16483928 (1), 17210567 (1), 15507212 (1)
    proline 4.84 3 11171383 (1), 17915251 (1), 10600384 (1)
    gtp 4.46 1 14992721 (1)
    tyrosine 0 1 12577064 (1)
    adp 0 1 17210567 (1)
    glutamate 0 1 16168524 (1)



    Find genes that share compounds with FMN1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FMN1 gene (4 alternative transcripts): 
    NM_198500.1  NM_001103184.3  NM_001277313.1  NM_001277314.1  

    Unigene Cluster for FMN1:

    Formin 1
    Hs.657649  [show with all ESTs]
    Unigene Representative Sequence: NM_001103184
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000334528(uc001zhf.4) ENST00000561249 ENST00000559047 ENST00000558882
    ENST00000559610 ENST00000560317 ENST00000558711 ENST00000558628 ENST00000558197(uc001zhg.2)
    ENST00000559150 ENST00000320930(uc001zhh.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FMN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FMN1 (see all 58):
    hsa-miR-579 hsa-miR-218-1* hsa-miR-29a hsa-miR-3167 hsa-miR-3613-3p hsa-miR-3116 hsa-miR-330-3p hsa-miR-4326
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FMN1
    Predesigned siRNA for gene silencing in human, mouse, rat FMN1
    Clone
    Products:
         
    OriGene clones in human, mouse for FMN1 (see all 6)
    OriGene ORF clones in mouse, rat for FMN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FMN1 (NM_001103184)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FMN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FMN1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FMN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FMN1
      QuantiTect SYBR Green Assays in human, mouse, rat FMN1
      QuantiFast Probe-based Assays in human, mouse, rat FMN1

    Additional mRNA sequence: 

    AL833157.1 BC029107.1 BC101971.1 BC103692.1 BC107593.1 CR749487.1 CR749577.1 

    10 DOTS entries:

    DT.444055  DT.99949032  DT.92417266  DT.97779785  DT.121081216  DT.95157338  DT.99993739  DT.121081262 
    DT.104668  DT.75125874 

    Selected AceView cDNA sequences (see all 88):

    BX280375 BM803128 AA480003 BM459001 CA430953 BX105237 BX281011 BU629502 
    BE275521 CA429949 N44866 CA423887 CB134345 CA430142 BC029107 BM474195 
    BM806611 AL833157 BE891057 AA905616 BE300783 AI417633 N42821 BU632857 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FMN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTTCAATT
    FMN1 Expression
    About this image


    FMN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neurons
             Type1 Off Cone Bipolar Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             Type1 Off Cone Bipolar Cells Inner Nuclear Layer
    FMN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FMN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.657649
        Custom PCR Arrays for FMN1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FMN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FMN1
    QuantiTect SYBR Green Assays in human, mouse, rat FMN1
    QuantiFast Probe-based Assays in human, mouse, rat FMN1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for FMN1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fmn11 , 5 formin 11, 5 82.15(n)1
    76.77(a)1
      2 (57.30 cM)5
    142601  NM_001285458.11  NP_001272387.11 
     1133277715 
    chicken
    (Gallus gallus)
    Aves FMN16
    Gallus gallus formin 1 (FMN1), mRNA.
    54(a)
    1 ↔ 1
    5(29701247-29817292)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fmn11 formin 1 58.63(n)
    52.41(a)
      100170173  NM_001129929.2  NP_001123401.2 
    zebrafish
    (Danio rerio)
    Actinopterygii FMN1 (4 of 4)6
    FMN1 (2 of 4)6
    (see all 4)
    formin 1
    (see all 4)
    73(a)
    67(a)
    (see all 4)
    1 ↔ many
    1 ↔ many
    (see all 4)
    17(699922-714146) ENSDARG00000088538
    Zv9_NA233(7625-45605) ENSDARG00000086384
    fruit fly
    (Drosophila melanogaster)
    Insecta capu6
    cappuccino
    21(a)
    1 → many
    2L(3872658-3902860)


    ENSEMBL Gene Tree for FMN1 (if available)
    TreeFam Gene Tree for FMN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FMN1 gene
    DAAM12  DIAPH12  FMNL32  FHDC12  FMNL12  DAAM22  INF22  FMNL22  
    GRID2IP2  DIAPH22  FMN22  DIAPH32  
    2 SIMAP similar genes for FMN1 using alignment to 6 protein entries:     FMN1_HUMAN (see all proteins):
    FMN2    DIAPH1

    Find genes that share paralogs with FMN1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FMN1 (see all 10658)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30814201,2
    C--10174441(+) AAAAA-/AA/   
       AAAAA
    GACAC
    2 -- int11NA 2
    rs105405961,2
    C--13134185(+) CCCTC-/CCTA  
            
    CCTAT
    2 -- int10--------
    rs112808921,2
    C--33057276(+) AAGTG-/TTTTGA
            
    TTTTA
    2 -- cds10--------
    rs714246681,2
    C--33057280(+) GTTTT-/GATTTT
            
    ATGTT
    2 -- cds11Minor allele frequency- GATTTT:0.50NA 2
    rs12587211,2
    C,F,A,H--33057357(+) ATCCAT/AACAAT 2 -- int113Minor allele frequency- A:0.17NS EA NA WA CSA 788
    rs1922566981,2
    --33057475(+) TTTTGA/GGTAAG 2 -- int10--------
    rs592315361,2
    C,F--33057501(+) GCCTGG/CCTGGT 2 -- int11Minor allele frequency- C:0.50WA 2
    rs1164982011,2
    F--33057540(+) TCTGGC/TCAAGT 2 -- int11Minor allele frequency- T:0.04WA 118
    rs572847641,2
    --33057566(+) GGGGAC/AAAATG 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs286979911,2
    C,F--33057567(+) GGGACT/AAATGG 2 -- int110Minor allele frequency- A:0.47NA WA CSA EA 372

    HapMap Linkage Disequilibrium report for FMN1 (33057747 - 33307747 bp, first 250kb of FMN1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FMN1 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1533512CNV Deletion17803354
    esv2749543CNV Deletion23290073
    esv1647338CNV Deletion17803354
    esv2749544CNV Deletion23290073
    esv1089006CNV Deletion17803354
    esv2422296CNV Duplication17116639
    esv268415CNV Insertion20981092
    esv1210728CNV Insertion17803354
    nsv832962CNV Loss17160897
    nsv1482CNV Loss18451855

    Human Gene Mutation Database (HGMD): FMN1
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing FMN1
    DNA2.0 Custom Variant and Variant Library Synthesis for FMN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 136535    OMIM disorders: --

    1 disease for FMN1:    
    About MalaCards
    renal hypoplasia

    1 disease from the University of Copenhagen DISEASES database for FMN1:
    Renal agenesis

    Find genes that share disorders with FMN1           About GenesLikeMe

    3 Novoseek inferred disease relationships for FMN1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 63.1 1 18669664 (1)
    tumors 0.43 2 19276357 (2)
    cancer 0 1 16358408 (1)

    Genetic Association Database (GAD): FMN1
    Human Genome Epidemiology (HuGE) Navigator: FMN1 (5 documents)

    Export disorders for FMN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FMN1 gene, integrated from 10 sources (see all 146):
    (articles sorted by number of sources associating them with FMN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human gene homologous to the formin gene residing at the murine limb deformity locus: chromosomal location and RFLPs. (PubMed id 1673046)1, 2, 3, 9 Maas R.L.... Leder P. (Am. J. Hum. Genet. 1991)
    2. Identification and characterization of the human FMN1 gene in silico. (PubMed id 15202026)1, 2, 9 Katoh M. and Katoh M. (Int. J. Mol. Med. 2004)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate. (PubMed id 20023658)1, 4 Mangold E....NAPthen M.M. (Nat. Genet. 2010)
    5. [A study of the single nucleotide polymorphism in seven genes (GHR, IGFBP3, IGFR1, IRS1, FMN1, ANXA2, TaGLN) in ethnic Russians and in patients with prostate cancer]. (PubMed id 20540360)1, 4 Lisitskaia K.V....Shishkin S.S. (Mol. Gen. Mikrobiol. Virusol. 2010)
    6. Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients. (PubMed id 19096130)1, 4 Kitahara K....Ota M. (Dis. Markers 2008)
    7. Identification of a short Spir interaction sequence at the C-terminal end of formin subgroup proteins. (PubMed id 19605360)1, 9 Pechlivanis M....Kerkhoff E. (J. Biol. Chem. 2009)
    8. Mammalian formin-1 participates in adherens junctions and polymerization of linear actin cables. (PubMed id 14647292)1, 9 Kobielak A....Fuchs E. (Nat. Cell Biol. 2004)
    9. Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. (PubMed id 23377640)1 (Am J Psychiatry 2013)
    10. Filopodia initiation: focus on the Arp2/3 complex and formins. (PubMed id 21975549)1 Yang C. and Svitkina T. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 342184 HGNC: 3768 AceView: FMN Ensembl:ENSG00000248905 euGenes: HUgn342184
    ECgene: FMN1 H-InvDB: FMN1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FMN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FMN1 gene:
    Search GeneIP for patents involving FMN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for FMN1   OriGene RNAi products in human, mouse, rat for FMN1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for FMN1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FMN1  
     OriGene qSTAR qPCR primer pairs in human, mouse for FMN1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FMN1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FMN1   OriGene Custom Protein Services for FMN1  

     
     
     Block miRNA regulation of human, mouse, rat FMN1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FMN1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FMN1 Predesigned siRNA for gene silencing in human, mouse, rat FMN1
     QuantiFast Probe-based Assays in human, mouse, rat FMN1 QuantiTect SYBR Green Assays in human, mouse, rat FMN1
     Custom PCR Arrays for FMN1 Search Chromatin IP Primers for FMN1
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FMN1  GeneGlobe Interaction Network for FMN1
     Regulatory tfbs in FMN1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for FMN1 GenScript cDNA clones with any tag delivered in your preferred vector for FMN1
     GenScript Custom Assay Services for FMN1 GenScript Custom overexpressing Cell Line Services for FMN1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FMN1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FMN1 antibodies
     FMN1 proteins
     FMN1 lysates
     Antibodies for FMN1
     See all of Abcam's Antibodies, Kits and Proteins for FMN1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for FMN1
     Antibodies for FMN1
     ELISAs for FMN1
     CLIAs for FMN1



     Browse ESI BIO Cell Lines and PureStem Progenitors for FMN1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMN1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for FMN1
     Browse SwitchGear Promoter luciferase reporter plasmids for FMN1
     Search ThermoFisher Antibodies for FMN1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FMN1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FMN1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FMN1
     Search LSBio for Antibodies for FMN1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for FMN1
      Search eBioscience for proteins for FMN1
      Search eBioscience for elisas for FMN1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FMN1 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4