Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FMN1 Gene

protein-coding   GIFtS: 52
GCID: GC15M033059

formin 1

(Previous name: formin (limb deformity) )
(Previous symbols: LD, FMN)
 Explore 16 diseases affiliated with
FMN1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FMN1    

Aliases
for FMN1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Formin 11 2     DKFZP686C22811
FMN1 2 3 5     FLJ451351
LD1 2 3 5     MGC1252881
Formin (Limb Deformity)1 2     MGC1252891
Limb Deformity Protein Homolog2 3     Formin-11

External Ids:    HGNC: 37681   Entrez Gene: 3421842   Ensembl: ENSG000002489057   OMIM: 1365355   UniProtKB: Q68DA73   

Export aliases for FMN1 gene to outside databases

Previous GC identifers: GC15M030854 GC15M033066 GC15M009919


Summaries
for FMN1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: FMN1_HUMAN, Q68DA7
Function: Plays a role in the formation of adherens junction and the polymerization of linear actin cables (By
similarity)




Genomic Views
for FMN1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FMN1 gene promoter:
         TBP   AP-1   TFIID   STAT3   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FMN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FMN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q13.3   Ensembl cytogenetic band:  15q13.3   HGNC cytogenetic band: 15q13-q14

FMN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FMN1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M033059:  view genomic region     (about GC identifiers)

Start:
 33,057,747 bp from pter      End:
 33,486,897 bp from pter
Size:
 429,151 bases      Orientation:
 minus strand

Proteins
for FMN1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FMN1_HUMAN, Q68DA7 (See protein sequence)
Recommended Name: Formin-1  
Size: 1419 amino acids; 157578 Da
Subunit: Interacts with alpha-catenin and may interact with tubulin (By similarity)
Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity). Cell junction, adherens junction (By
similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Localization to the
adherens junctions is alpha-catenin-dependent. Also localizes to F-actin bundles originating from adherens junctions
and to microtubules (By similarity)
Developmental stage: Expressed in fetal kidney and fetal lung
Secondary accessions: Q3B7I6 Q3ZAR4 Q6ZSY1
Alternative splicing: 4 isoforms:  Q68DA7-1   Q68DA7-2   Q68DA7-3   Q68DA7-5   (Ref.3 (AAI03693/AAI07594) sequences are in conflict in position: 171:G->V. Ref.3 (AAI07594) sequence is in conflict in position: 239:G->E)

Explore the universe of human proteins at neXtProt for FMN1: NX_Q68DA7

Post-translational modifications:

  • Phosphorylated on serine and possibly threonine residues (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q68DA7

    • FMN1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001096654.1  
    ENSEMBL proteins: 
     ENSP00000333950   ENSP00000453443   ENSP00000454047   ENSP00000453110   ENSP00000453266  
     ENSP00000453682   ENSP00000452984   ENSP00000325166  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: FMN1
    OriGene Custom Protein Services for FMN1 
    GenScript Custom Purified and Recombinant Proteins Services for FMN1
    Novus Biologicals FMN1 Proteins
    Novus Biologicals FMN1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FMN1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--
    GO:0005912adherens junction IEA--
    GO:0015629actin cytoskeleton IEA--


    FMN1 for ontologies           About GeneDecksing



    FMN1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FMN1 
    GenScript Custom Superior Antibodies Services for FMN1
    Novus Biologicals FMN1 Antibodies
    Search for Antibodies for FMN1 at Abcam  
    Uscn Antibodies for FMN1
    Search ThermoFisher Antibodies for FMN1

    Assay Products for FMN1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FMN1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for FMN1

    Protein Domains /
    Families
    for FMN1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FMN1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015425 FH2_actin-bd
     IPR003104 Actin-bd_FH2/DRF_autoreg
     IPR001265 Formin

    Graphical View of Domain Structure for InterPro Entry Q68DA7

    ProtoNet protein and cluster: Q68DA7

    UniProtKB/Swiss-Prot: FMN1_HUMAN, Q68DA7
    Similarity: Belongs to the formin homology family. Cappuccino subfamily
    Similarity: Contains 1 FH1 (formin homology 1) domain
    Similarity: Contains 1 FH2 (formin homology 2) domain


    Function
    for FMN1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FMN1_HUMAN, Q68DA7
    Function: Plays a role in the formation of adherens junction and the polymerization of linear actin cables (By
    similarity)

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FMN1
    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate FMN1 (see all 58):
    hsa-miR-579 hsa-miR-218-1* hsa-miR-29a hsa-miR-3167 hsa-miR-3613-3p hsa-miR-3116 hsa-miR-330-3p hsa-miR-4326
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FMN1 (see all 4)
    OriGene shRNA RFP: FMN1
    OriGene siRNA: FMN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FMN1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for FMN1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FMN1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FMN1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: FMN1 (NM_001103184)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FMN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FMN1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for FMN1
    Search LifeMap BioReagents cell lines for FMN1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMN1

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003779actin binding IEA--
    GO:0005515protein binding ----
    GO:0017124SH3 domain binding IEA--


    FMN1 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for FMN1:
     Big cells  Increased focal adhesion (FA)   Stronger migration  Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-outs for FMN1: Fmn1tm1.1Zlr Fmn1tm1Zlr Fmn1tm2Led Fmn1tm1Led Fmn1tm1Awb
         10 MGI mutant phenotypes (inferred from 12 alleles) (MGI details for Fmn1):
     cellular  integument  limbs/digits/tail  mortality/aging  no phenotypic analysis 
     normal  pigmentation  renal/urinary system  reproductive system  skeleton 

    FMN1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FMN1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cytoskeleton remodeling Slit-Robo signaling
    		Cell adhesion Cadherin-mediated cell adhesion0.28
    		Cell adhesion_Cadherin-mediated cell adhesion0.28
    2E-cadherin signaling in keratinocytes
    		E-cadherin signaling in keratinocytes1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for FMN1
        Cell adhesion Cadherin-mediated cell adhesion


    1 GeneGo (Thomson Reuters) Pathway for FMN1
        Cell adhesion Cadherin-mediated cell adhesion

    1 BioSystems Pathway for FMN1 
        E-cadherin signaling in keratinocytes



    FMN1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FMN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/11 Interacting proteins for FMN1 (Q68DA73 ENSP000003339504) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FNBP4Q8N3X13, ENSP000002637734I2D: score=1 STRING: ENSP00000263773
    SRGAP2O750443, ENSP000004080894I2D: score=1 STRING: ENSP00000408089
    PRPF40AO754003I2D: score=2 
    FNBP1Q96RU33I2D: score=1 
    CTNNA1ENSP000003046694STRING: ENSP00000304669
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010467gene expression IEA--
    GO:0030036actin cytoskeleton organization IEA--
    GO:0030838positive regulation of actin filament polymerization IEA--
    GO:0035136forelimb morphogenesis IEA--
    GO:0035137hindlimb morphogenesis IEA--


    FMN1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FMN1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FMN1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FMN1
    9 Novoseek chemical compound relationships for FMN1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mdi-a 95 9 19457867 (2), 17855386 (1), 18239683 (1), 16361707 (1) (see all 8)
    spir 62.9 3 19605360 (1), 16901698 (1), 15053972 (1)
    actomyosin 52.9 1 16487696 (1)
    atp 6.63 4 20192778 (1), 16483928 (1), 17210567 (1), 15507212 (1)
    proline 4.84 3 11171383 (1), 17915251 (1), 10600384 (1)
    gtp 4.46 1 14992721 (1)
    tyrosine 0 1 12577064 (1)
    adp 0 1 17210567 (1)
    glutamate 0 1 16168524 (1)

    Search CenterWatch for drugs/clinical trials and news about FMN1 

    Transcripts
    for FMN1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FMN1 gene (2 alternative transcripts): 
    NM_198500.1  NM_001103184.2  

    Unigene Cluster for FMN1:

    Formin 1
    Hs.657649  [show with all ESTs]
    Unigene Representative Sequence: NM_001103184
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000334528(uc001zhf.4) ENST00000561249 ENST00000559047 ENST00000558882
    ENST00000559610 ENST00000560317 ENST00000558711 ENST00000558628 ENST00000558197(uc001zhg.2)
    ENST00000559150 ENST00000320930(uc001zhh.3)

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FMN1
    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate FMN1 (see all 58):
    hsa-miR-579 hsa-miR-218-1* hsa-miR-29a hsa-miR-3167 hsa-miR-3613-3p hsa-miR-3116 hsa-miR-330-3p hsa-miR-4326
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FMN1 (see all 4)
    OriGene shRNA RFP: FMN1
    OriGene siRNA: FMN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FMN1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FMN1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FMN1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: FMN1 (NM_001103184)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FMN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FMN1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FMN1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FMN1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FMN1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FMN1

    Additional cDNA sequence: 

    AL833157.1 BC029107.1 BC101971.1 BC103692.1 BC107593.1 CR749487.1 CR749577.1 

    10 DOTS entries:

    DT.444055  DT.99949032  DT.92417266  DT.97779785  DT.121081216  DT.95157338  DT.99993739  DT.121081262 
    DT.104668  DT.75125874 

    24/88 AceView cDNA sequences (see all 88):

    BX281011 AA480003 BU629502 BM459001 CA430953 BX105237 BX280375 BM803128 
    BE275521 BU632857 BM470222 CR749487 CR749577 BE729567 AU253167 CB268851 
    N42821 BM663620 AI417633 BE277390 BF305647 AI017618 BC029107 CA430142 

    GeneLoc Exon Structure


    Expression
    for FMN1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FMN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCTTTCAATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FMN1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerType1 Off Cone Bipolar CellsBipolar, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See FMN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FMN1

    SOURCE GeneReport for Unigene cluster: Hs.657649
        SABiosciences Custom PCR Arrays for FMN1
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FMN1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FMN1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FMN1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FMN1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMN1

    Orthologs
    for FMN1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FMN1 gene from 3/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FMN11 formin 1 65.95(n)
    62.94(a)    		   386747  NM_204423.1  NP_989754.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii fmn11 formin 1 52.86(n)
    46.03(a)    		   561077  XM_684477.2  XP_689569.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta capu6
    		 cappuccino
    		 15(a)
    		 1 → many
    		 2L(3872658-3902860)


    ENSEMBL Gene Tree for FMN1 (if available)
    TreeFam Gene Tree for FMN1 (if available) 

    Paralogs
    for FMN1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FMN1 gene
    DIAPH12  DAAM12  FMNL32  FHDC12  FMNL12  DAAM22  FMNL22  INF22  
    GRID2IP2  DIAPH22  DIAPH32  FMN22  
    2 SIMAP similar genes for FMN1 using alignment to 6 protein entries:     FMN1_HUMAN (see all proteins):
    FMN2    DIAPH1

    FMN1 for paralogs           About GeneDecksing



    Genomic Variants
    for FMN1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7208 NCBI SNPs in FMN1 are shown (see all 7208)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs112808921,2
    		C,--33057276(+) AAGTG-/TTTTGA
                TTTTA     		1 -- ds50010--------
    rs714246681,2
    		C--33057280(+) GTTTT-/GATTTT
                ATGTT     		1 -- ds50011Minor allele frequency- GATTTT:0.50NA 2
    rs12587211,2
    		C,F,A,H,--33057357(+) ATCCAT/AACAAT 1 -- ds500113Minor allele frequency- A:0.17NS EA NA WA CSA 788
    rs1922566981,2
    		--33057475(+) TTTTGA/GGTAAG 1 -- ds50010--------
    rs592315361,2
    		C,--33057501(+) GCCTGG/CCTGGT 1 -- ds50011Minor allele frequency- C:0.50WA 2
    rs1164982011,2
    		F,--33057540(+) TCTGGC/TCAAGT 1 -- ds50011Minor allele frequency- T:0.04WA 118
    rs572847641,2
    		--33057566(+) GGGGAC/AAAATG 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs286979911,2
    		C,F,--33057567(+) GGGACT/AAATGG 1 -- ds500110Minor allele frequency- A:0.47NA WA CSA EA 372
    rs12587221,2
    		C,H,--33057640(+) GTACCT/CGAGTG 1 -- ds500116Minor allele frequency- C:0.00NS EA WA NA CSA 792
    rs47800391,2
    		C,F,A,--33057710(+) TTACAC/TGCCTC 1 -- ds500113Minor allele frequency- T:0.46NA WA CSA EA 514

    HapMap Linkage Disequilibrium report for FMN1 (33057747 - 33307747 bp, first 250kb of FMN1)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for FMN1
         2 CNVs: 7058 5324
         2 Indels: 25506 25505
    Human Gene Mutation Database (HGMD): FMN1

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FMN1
    DNA2.0 Custom Variant and Variant Library Synthesis for FMN1

    Disorders / Diseases
    for FMN1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FMN1 for disorders           About GeneDecksing

    OMIM gene information: 136535    OMIM disorders: --

    16 diseases for FMN1:    About MalaCards
    wiskott-aldrich syndrome    asphyxiating thoracic dystrophy    focal segmental glomerulosclerosis    thoracic outlet syndrome
    sarcomatosis    cleft lip    cleft palate    renal agenesis
    hearing loss    glomerulosclerosis    renal hypoplasia    synostosis
    prostate cancer    prostatitis    pancreatitis    alcoholism

    2 diseases from the University of Copenhagen DISEASES database for FMN1:
    Renal agenesis     Sarcomatosis

    3 Novoseek disease relationships for FMN1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 63.1 1 18669664 (1)
    tumors 0.43 2 19276357 (2)
    cancer 0 1 16358408 (1)

    Human Genome Epidemiology (HuGE) Navigator: FMN1 (5 documents)

    Export disorders for FMN1 gene to outside databases

    Publications
    for FMN1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FMN1 gene, integrated from 9 sources (see all 139):
    (articles sorted by number of sources associating them with FMN1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A human gene homologous to the formin gene residing at the murine limb deformity locus: chromosomal location and RFLPs. (PubMed id 1673046)1, 2, 3, 9 Maas R.L.... Leder P. (1991)
    2. Identification and characterization of the human FMN1 gene in silico. (PubMed id 15202026)1, 2, 9 Katoh M. and Katoh M. (2004)
    3. Identification of a short Spir interaction sequence a t the C-terminal end of formin subgroup proteins. (PubMed id 19605360)1, 9 Pechlivanis M....Kerkhoff E. (2009)
    4. Mammalian formin-1 participates in adherens junctions and polymerization of linear actin cables. (PubMed id 14647292)1, 9 Kobielak A....Fuchs E. (2004)
    5. Filopodia initiation: focus on the Arp2/3 complex and formins. (PubMed id 21975549)1 Yang C. and Svitkina T. (2011)
    6. Replication of previous genome-wide association studi es of bone mineral density in premenopausal American women. (PubMed id 20200978)1 Ichikawa S....Econs M.J. (2010)
    7. Genomic rearrangements of the GREM1-FMN1 locus cause oligosyndactyly, radio-ulnar synostosis, hearing loss, renal defects syndrome a nd Cenani--Lenz-like non-syndromic oligosyndactyly. (PubMed id 20610440)1 Dimitrov B.I....Debeer P. (2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    9. Genome-wide association study identifies two suscepti bility loci for nonsyndromic cleft lip with or without cleft palate. (PubMed id 20023658)1 Mangold E....NAPthen M.M. (2010)
    10. [A study of the single nucleotide polymorphism in sev en genes (GHR, IGFBP3, IGFR1, IRS1, FMN1, ANXA2, TaGLN) in ethnic Russians and in patients with prostate cancer] (PubMed id 20540360)1 Lisitskaia K.V....Shishkin S.S. (2010)

    External Searches for FMN1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FMN1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 342184 HGNC: 3768 AceView: FMN Ensembl:ENSG00000248905 euGenes: HUgn342184
    ECgene: FMN1 H-InvDB: FMN1

    Other Databases showing FMN1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FMN1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FMN1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FMN1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FMN1 gene:
    Search GeneIP for patents involving FMN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for FMN1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for FMN1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FMN1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FMN1  
     OriGene Protein Over-expression Lysate for FMN1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for FMN1   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FMN1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FMN1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FMN1   OriGene Custom Protein Services for FMN1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FMN1
     Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FMN1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FMN1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FMN1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FMN1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FMN1
     GenScript Custom Purified and Recombinant Proteins Services for FMN1 GenScript cDNA clones with any tag delivered in your preferred vector for FMN1
     GenScript Custom Assay Services for FMN1 GenScript Custom Superior Antibodies Services for FMN1
     GenScript Custom overexpressing Cell Line Services for FMN1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FMN1 promoter
     Search Chromatin IP Primers for FMN1
     RT2 qPCR Primer Assay in human, mouse / rat FMN1
     GNC Network for FMN1
     SABiosciences Custom PCR Arrays for FMN1
     Search Tocris compounds for FMN1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FMN1 antibodies
     FMN1 proteins
     FMN1 lysates
     Search for Antibodies for FMN1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for FMN1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     FMN1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for FMN1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FMN1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for FMN1
     Browse SwitchGear Promoter luciferase reporter plasmids for FMN1
     Search ThermoFisher Antibodies for FMN1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FMN1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      FMN1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4