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Aliases for FLYWCH2 Gene

Aliases for FLYWCH2 Gene

  • FLYWCH Family Member 2 2 3 5

External Ids for FLYWCH2 Gene

Previous GeneCards Identifiers for FLYWCH2 Gene

  • GC16P002874
  • GC16P002934

Summaries for FLYWCH2 Gene

GeneCards Summary for FLYWCH2 Gene

FLYWCH2 (FLYWCH Family Member 2) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is FLYWCH1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLYWCH2 Gene

Genomics for FLYWCH2 Gene

Regulatory Elements for FLYWCH2 Gene

Enhancers for FLYWCH2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F002881 1 ENCODE 23.8 +0.3 347 2.7 HDGF PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FLYWCH2 FLYWCH1 ENSG00000200059 ENSG00000261240 CLUAP1 TIGD7 PRSS22 SRRM2-AS1 SNORD60 SNHG19
GH16F002903 1.8 FANTOM5 Ensembl ENCODE 22.5 +22.9 22897 4.2 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF548 CREBBP FLYWCH2 THOC6 LOC105371055 ZNF597 ZNF598 ENSG00000200059 ENSG00000261240 ZNF263 SNORA64
GH16F002911 0.9 ENCODE 20.8 +29.5 29517 2.5 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 KLF13 FLYWCH2 PRSS27 LOC101929566 PRSS22 FLYWCH1 GC16M002924
GH16F002915 1.3 Ensembl ENCODE 19.3 +33.3 33267 1.9 PKNOX1 ARID4B SIN3A ZNF2 ZNF48 GTF3C2 ZNF121 GLIS2 ZNF548 SP3 ZNF598 CREBBP ENSG00000255513 SNORA64 LOC105371055 ZNF263 THOC6 FLYWCH2 TRAF7 SNORD60
GH16F002890 1.1 Ensembl ENCODE 17.9 +8.2 8183 1.2 GTF2F1 KLF1 TAL1 KLF17 MAX ZNF384 BRCA1 RFX5 HIC1 ZNF121 FLYWCH2 PRSS22 PRSS30P LOC101929566 FLYWCH1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FLYWCH2 on UCSC Golden Path with GeneCards custom track

Promoters for FLYWCH2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001503088 197 2400 HDGF PKNOX1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for FLYWCH2 Gene

Chromosome:
16
Start:
2,882,804 bp from pter
End:
2,899,382 bp from pter
Size:
16,579 bases
Orientation:
Plus strand

Genomic View for FLYWCH2 Gene

Genes around FLYWCH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FLYWCH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FLYWCH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FLYWCH2 Gene

Proteins for FLYWCH2 Gene

  • Protein details for FLYWCH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CP2-FWCH2_HUMAN
    Recommended name:
    FLYWCH family member 2
    Protein Accession:
    Q96CP2

    Protein attributes for FLYWCH2 Gene

    Size:
    140 amino acids
    Molecular mass:
    14564 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FLYWCH2 Gene

Post-translational modifications for FLYWCH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FLYWCH2 Gene

No data available for DME Specific Peptides for FLYWCH2 Gene

Domains & Families for FLYWCH2 Gene

Protein Domains for FLYWCH2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FLYWCH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FLYWCH2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FLYWCH2 Gene

Function for FLYWCH2 Gene

Gene Ontology (GO) - Molecular Function for FLYWCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with FLYWCH2: view

Animal Model Products

miRNA for FLYWCH2 Gene

miRTarBase miRNAs that target FLYWCH2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FLYWCH2 Gene

Localization for FLYWCH2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FLYWCH2 Gene COMPARTMENTS Subcellular localization image for FLYWCH2 gene
Compartment Confidence
nucleus 4
cytosol 1

Gene Ontology (GO) - Cellular Components for FLYWCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with FLYWCH2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FLYWCH2 Gene

Pathways & Interactions for FLYWCH2 Gene

SuperPathways for FLYWCH2 Gene

No Data Available

Interacting Proteins for FLYWCH2 Gene

Gene Ontology (GO) - Biological Process for FLYWCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with FLYWCH2: view

No data available for Pathways by source and SIGNOR curated interactions for FLYWCH2 Gene

Transcripts for FLYWCH2 Gene

Unigene Clusters for FLYWCH2 Gene

FLYWCH family member 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FLYWCH2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1: -
SP2:
SP3:
SP4: -

Relevant External Links for FLYWCH2 Gene

GeneLoc Exon Structure for
FLYWCH2
ECgene alternative splicing isoforms for
FLYWCH2

Expression for FLYWCH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FLYWCH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FLYWCH2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.3), CD8 Tcells (9.0), and Blymphocyte (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FLYWCH2 Gene



Protein tissue co-expression partners for FLYWCH2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FLYWCH2 Gene:

FLYWCH2

SOURCE GeneReport for Unigene cluster for FLYWCH2 Gene:

Hs.534525
genes like me logo Genes that share expression patterns with FLYWCH2: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FLYWCH2 Gene

Orthologs for FLYWCH2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FLYWCH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FLYWCH2 34 35
  • 99.29 (n)
dog
(Canis familiaris)
Mammalia FLYWCH2 34 35
  • 84.59 (n)
mouse
(Mus musculus)
Mammalia Flywch2 34 16 35
  • 83.91 (n)
rat
(Rattus norvegicus)
Mammalia Flywch2 34
  • 82.5 (n)
cow
(Bos Taurus)
Mammalia FLYWCH2 34 35
  • 82.18 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
OneToMany
Species where no ortholog for FLYWCH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FLYWCH2 Gene

ENSEMBL:
Gene Tree for FLYWCH2 (if available)
TreeFam:
Gene Tree for FLYWCH2 (if available)

Paralogs for FLYWCH2 Gene

Paralogs for FLYWCH2 Gene

(1) SIMAP similar genes for FLYWCH2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FLYWCH2: view

Variants for FLYWCH2 Gene

Sequence variations from dbSNP and Humsavar for FLYWCH2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10153146 -- 2,885,344(+) aaaaa(A/C/T)atata intron-variant
rs1034709 -- 2,891,319(+) AAGGA(C/T)GTGGC intron-variant
rs1052167 -- 2,899,208(+) CTGTC(C/T)GCAGG utr-variant-3-prime
rs1063676 -- 2,883,279(+) TAACA(C/G)CGCGA intron-variant, utr-variant-5-prime
rs1063677 -- 2,895,247(+) GTGAC(C/G)GTGGG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FLYWCH2 Gene

Variant ID Type Subtype PubMed ID
esv2666650 CNV deletion 23128226
esv2673165 CNV deletion 23128226
esv3637640 CNV loss 21293372
nsv436210 CNV deletion 17901297
nsv833124 CNV loss 17160897
nsv952906 CNV deletion 24416366

Variation tolerance for FLYWCH2 Gene

Residual Variation Intolerance Score: 41.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FLYWCH2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FLYWCH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLYWCH2 Gene

Disorders for FLYWCH2 Gene

Relevant External Links for FLYWCH2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FLYWCH2

No disorders were found for FLYWCH2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FLYWCH2 Gene

Publications for FLYWCH2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1. (PMID: 26752685) Scholz C.C. … Taylor C.T. (PLoS Biol. 2016) 3 64
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for FLYWCH2 Gene

Sources for FLYWCH2 Gene

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