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FLYWCH2 Gene

protein-coding   GIFtS: 42
GCID: GC16P002934

FLYWCH Family Member 2

  Search for FLYWCH2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FLYWCH Family Member 21 2

External Ids:    HGNC: 251781   Entrez Gene: 1149842   Ensembl: ENSG000001620767   UniProtKB: Q96CP23   

Export aliases for FLYWCH2 gene to outside databases

Previous GC identifer: GC16P002874


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FLYWCH2 Gene:
FLYWCH2 (FLYWCH family member 2) is a protein-coding gene. An important paralog of this gene is FLYWCH1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FLYWCH2 gene promoter:
         Bach1   RP58   Pax-5   POU3F1   NF-E2 p45   PPAR-gamma1   Cart-1   PPAR-gamma2   Msx-1   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFLYWCH2 promoter sequence
   Search Chromatin IP Primers for FLYWCH2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FLYWCH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

FLYWCH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FLYWCH2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P002934:  view genomic region     (about GC identifiers)

Start:
2,933,187 bp from pter      End:
2,949,383 bp from pter
Size:
16,197 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FWCH2_HUMAN, Q96CP2 (See protein sequence)
Recommended Name: FLYWCH family member 2  
Size: 140 amino acids; 14564 Da

Explore the universe of human proteins at neXtProt for FLYWCH2: NX_Q96CP2

Explore proteomics data for FLYWCH2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FLYWCH2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001135971.1  NP_001135972.1  NP_612448.1  

    ENSEMBL proteins: 
     ENSP00000380159   ENSP00000293981   ENSP00000461275   ENSP00000459223  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q96CP2


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0044822poly(A) RNA binding IDA--
         
    FLYWCH2 for ontologies           About GeneDecksing


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    hsa-miR-548j hsa-miR-548w hsa-miR-559 hsa-miR-520d-5p hsa-miR-548i hsa-miR-548h hsa-miR-548c-5p hsa-miR-548y
    SwitchGear 3'UTR luciferase reporter plasmidFLYWCH2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    FLYWCH2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FLYWCH2
    Interactions:

        Search GeneGlobe Interaction Network for FLYWCH2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for FLYWCH2 (ENSP000002939814) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    FLYWCH2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FLYWCH2 (FWCH2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FLYWCH2 gene (3 alternative transcripts): 
    NM_001142499.1  NM_001142500.1  NM_138439.2  

    Unigene Cluster for FLYWCH2:

    FLYWCH family member 2
    Hs.534525  [show with all ESTs]
    Unigene Representative Sequence: BU902355
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396958(uc002csa.3 uc010uwj.2 uc010uwk.2) ENST00000293981
    ENST00000573965 ENST00000572006 ENST00000572786
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FLYWCH2 (see all 14):
    hsa-miR-548j hsa-miR-548w hsa-miR-559 hsa-miR-520d-5p hsa-miR-548i hsa-miR-548h hsa-miR-548c-5p hsa-miR-548y
    SwitchGear 3'UTR luciferase reporter plasmidFLYWCH2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FLYWCH2
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      QuantiTect SYBR Green Assays in human, mouse, rat FLYWCH2
      QuantiFast Probe-based Assays in human, mouse, rat FLYWCH2

    Additional mRNA sequence: BC014089.2 

    6 DOTS entries:

    DT.311594  DT.100815096  DT.95373935  DT.443825  DT.97822673  DT.92421068 

    Selected AceView cDNA sequences (see all 298):

    BM693039 BM918403 BQ636068 BU857650 BX398947 CD673911 BM466621 BX116689 
    CD675307 CD672242 BX355080 BM715166 CD722400 BU902079 AA284150 CR601271 
    BM785027 CD671260 NM_032296 BM549378 BM562651 AA588656 AL136585 BM667967 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FLYWCH2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
    SP1:        -                                       
    SP2:                                                
    SP3:                                                
    SP4:              -                                 


    ECgene alternative splicing isoforms for FLYWCH2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FLYWCH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCCTGGGGG
    FLYWCH2 Expression
    About this image


    FLYWCH2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Liver (Hepatobiliary System)
             Hematopoietic Stem Cells Liver Bud
     
     Blood (Cardiovascular System)
             Hematopoietic Stem Cells Liver Bud
    FLYWCH2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FLYWCH2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534525
        Custom PCR Arrays for FLYWCH2
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for FLYWCH2 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Flywch21 , 5 FLYWCH family member 21, 5 83.91(n)1
    82.76(a)1
      17 (12.05 cM)5
    769171  NM_029798.31  NP_084074.11 
     237769165 


    ENSEMBL Gene Tree for FLYWCH2 (if available)
    TreeFam Gene Tree for FLYWCH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FLYWCH2 gene
    FLYWCH12  
    1 SIMAP similar gene for FLYWCH2 using alignment to 3 protein entries:     FWCH2_HUMAN (see all proteins):
    FLYWCH1

    FLYWCH2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FLYWCH2 (see all 521)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1444626161,2
    C--2931210(+) CAAGAC/TGGTGA 3 -- us2k10--------
    rs1424864391,2
    --2931251(+) TTAGCC/TGGGTG 3 -- us2k10--------
    rs1133397501,2
    C,F--2931278(+) TAATCC/TCAGCT 3 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1420302101,2
    C--2931350(+) AGATCA/GTGCTA 3 -- us2k10--------
    rs1159772951,2
    C,F--2931364(+) CACTCC/TGGTCT 3 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1850102461,2
    --2931455(+) CAGCAC/GTTTTG 3 -- us2k10--------
    rs1902085281,2
    --2931555(+) AAATTA/GAGCAT 3 -- us2k10--------
    rs1825109151,2
    --2931724(+) TTGACA/CTCAGA 3 -- us2k10--------
    rs1148648531,2
    C--2931745(+) CAAAGA/GTATTT 3 -- us2k10--------
    rs1116713871,2
    C,F--2931818(+) AATGCA/GCAAAG 3 -- us2k12Minor allele frequency- G:0.10CSA WA 120

    HapMap Linkage Disequilibrium report for FLYWCH2 (2933187 - 2949383 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FLYWCH2 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv436210CNV Deletion17901297
    esv2666650CNV Deletion23128226
    esv2673165CNV Deletion23128226
    dgv2574n71CNV Loss21882294
    nsv905165CNV Loss21882294
    nsv905152CNV Loss21882294
    nsv905170CNV Loss21882294
    nsv833124CNV Loss17160897
    dgv2575n71CNV Loss21882294
    nsv905169CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FLYWCH2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FLYWCH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    2. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    3. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    6. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    7. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 114984 HGNC: 25178 AceView: DKFZp761A132 Ensembl:ENSG00000162076 euGenes: HUgn114984
    ECgene: FLYWCH2 H-InvDB: FLYWCH2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FLYWCH2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FLYWCH2 gene:
    Search GeneIP for patents involving FLYWCH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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