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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FLYWCH2 Gene

protein-coding   GIFtS: 41
GCID: GC16P002934

FLYWCH Family Member 2

  Search for FLYWCH2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
FLYWCH Family Member 21 2

External Ids:    HGNC: 251781   Entrez Gene: 1149842   Ensembl: ENSG000001620767   UniProtKB: Q96CP23   

Export aliases for FLYWCH2 gene to outside databases

Previous GC identifer: GC16P002874


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FLYWCH2 Gene: 
FLYWCH2 (FLYWCH family member 2) is a protein-coding gene. GO annotations related to this gene include molecular_function. An important paralog of this gene is FLYWCH1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FLYWCH2 gene promoter:
         Bach1   RP58   Pax-5   POU3F1   NF-E2 p45   PPAR-gamma1   Cart-1   PPAR-gamma2   Msx-1   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFLYWCH2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FLYWCH2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FLYWCH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

FLYWCH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FLYWCH2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P002934:  view genomic region     (about GC identifiers)

Start:
2,933,187 bp from pter      End:
2,949,383 bp from pter
Size:
16,197 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FWCH2_HUMAN, Q96CP2 (See protein sequence)
Recommended Name: FLYWCH family member 2  
Size: 140 amino acids; 14564 Da

Explore the universe of human proteins at neXtProt for FLYWCH2: NX_Q96CP2

Explore proteomics data for FLYWCH2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96CP2

  • FLYWCH2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FLYWCH2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001135971.1  NP_001135972.1  NP_612448.1  

    ENSEMBL proteins: 
     ENSP00000380159   ENSP00000293981   ENSP00000461275   ENSP00000459223  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    FLYWCH2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q96CP2


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    FLYWCH2 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FLYWCH2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for FLYWCH2 (ENSP000002939814) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    FLYWCH2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FLYWCH2 (FWCH2)

    Search CenterWatch for drugs/clinical trials and news about FLYWCH2 / FWCH2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FLYWCH2 gene (3 alternative transcripts): 
    NM_001142499.1  NM_001142500.1  NM_138439.2  

    Unigene Cluster for FLYWCH2:

    FLYWCH family member 2
    Hs.534525  [show with all ESTs]
    Unigene Representative Sequence: BU902355
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396958(uc002csa.3 uc010uwj.2 uc010uwk.2) ENST00000293981
    ENST00000573965 ENST00000572006 ENST00000572786
    miRNA
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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate FLYWCH2 (see all 14):
    hsa-miR-548j hsa-miR-548w hsa-miR-559 hsa-miR-520d-5p hsa-miR-548i hsa-miR-548h hsa-miR-548c-5p hsa-miR-548y
    SwitchGear 3'UTR luciferase reporter plasmidFLYWCH2 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Additional mRNA sequence: BC014089.2 

    6 DOTS entries:

    DT.311594  DT.100815096  DT.95373935  DT.443825  DT.97822673  DT.92421068 

    24/298 AceView cDNA sequences (see all 298):

    BM669271 BU902079 AL136585 NM_032296 BM661807 BM715166 BX355080 BQ636068 
    CA454125 BM705997 CD672241 BQ435088 BM667967 AA910072 CD674035 BM562651 
    BM693039 CD675307 CD674036 AA588656 BM785027 BX116689 CD671260 BM784140 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FLYWCH2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
    SP1:        -                                       
    SP2:                                                
    SP3:                                                
    SP4:              -                                 


    ECgene alternative splicing isoforms for FLYWCH2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FLYWCH2 expression in normal human tissues (normalized intensities)      FLYWCH2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCCTGGGGG
    FLYWCH2 Expression
    About this image


    FLYWCH2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Liver (Hepatobiliary System)
             Hematopoietic Stem Cells Liver Bud
     
     Blood (Cardiovascular System)
             Hematopoietic Stem Cells Liver Bud
     
     Dermis (Integumentary System)
             Guard Dermal Papilla Cells Dermal Papilla

    See FLYWCH2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FLYWCH2

    SOURCE GeneReport for Unigene cluster: Hs.534525
        SABiosciences Custom PCR Arrays for FLYWCH2
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for FLYWCH2 gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Flywch21 , 5 FLYWCH family member 21, 5 77.78(n)1
    73.19(a)1
      17 (12.05 cM)5
    769171  NM_029798.31  NP_084074.11 
     237769165 


    ENSEMBL Gene Tree for FLYWCH2 (if available)
    TreeFam Gene Tree for FLYWCH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FLYWCH2 gene
    FLYWCH12  
    1 SIMAP similar gene for FLYWCH2 using alignment to 3 protein entries:     FWCH2_HUMAN (see all proteins):
    FLYWCH1

    FLYWCH2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/521 SNPs in FLYWCH2 are shown (see all 521)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1444626161,2
    C--2931210(+) CAAGAC/TGGTGA 3 -- us2k10--------
    rs1424864391,2
    --2931251(+) TTAGCC/TGGGTG 3 -- us2k10--------
    rs1133397501,2
    C,F--2931278(+) TAATCC/TCAGCT 3 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1420302101,2
    C--2931350(+) AGATCA/GTGCTA 3 -- us2k10--------
    rs1159772951,2
    C,F--2931364(+) CACTCC/TGGTCT 3 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1850102461,2
    --2931455(+) CAGCAC/GTTTTG 3 -- us2k10--------
    rs1902085281,2
    --2931555(+) AAATTA/GAGCAT 3 -- us2k10--------
    rs1825109151,2
    --2931724(+) TTGACA/CTCAGA 3 -- us2k10--------
    rs1148648531,2
    C--2931745(+) CAAAGA/GTATTT 3 -- us2k10--------
    rs1116713871,2
    C,F--2931818(+) AATGCA/GCAAAG 3 -- us2k12Minor allele frequency- G:0.10CSA WA 120

    HapMap Linkage Disequilibrium report for FLYWCH2 (2933187 - 2949383 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for FLYWCH2 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv436210CNV Deletion17901297
    esv2666650CNV Deletion23128226
    esv2673165CNV Deletion23128226
    dgv2574n71CNV Loss21882294
    nsv905165CNV Loss21882294
    nsv905152CNV Loss21882294
    nsv905170CNV Loss21882294
    nsv833124CNV Loss17160897
    dgv2575n71CNV Loss21882294
    nsv905169CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FLYWCH2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FLYWCH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    3. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    4. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    6. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 114984 HGNC: 25178 AceView: DKFZp761A132 Ensembl:ENSG00000162076 euGenes: HUgn114984
    ECgene: FLYWCH2 H-InvDB: FLYWCH2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FLYWCH2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FLYWCH2 gene:
    Search GeneIP for patents involving FLYWCH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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