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Aliases for FLYWCH1 Gene

Aliases for FLYWCH1 Gene

  • FLYWCH-Type Zinc Finger 1 2 3 5
  • KIAA1552 4

External Ids for FLYWCH1 Gene

Previous GeneCards Identifiers for FLYWCH1 Gene

  • GC16P002902
  • GC16P002961
  • GC16P002935

Summaries for FLYWCH1 Gene

GeneCards Summary for FLYWCH1 Gene

FLYWCH1 (FLYWCH-Type Zinc Finger 1) is a Protein Coding gene. Diseases associated with FLYWCH1 include Parenchymatous Neurosyphilis and Tertiary Neurosyphilis. An important paralog of this gene is FLYWCH2.

Additional gene information for FLYWCH1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLYWCH1 Gene

Genomics for FLYWCH1 Gene

Regulatory Elements for FLYWCH1 Gene

Enhancers for FLYWCH1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H002881 1.1 ENCODE 27.8 -28.8 -28771 2.7 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS TBL3 FLYWCH1 FLYWCH2 ENSG00000261938 CREBBP ZNF598 ENSG00000200059 TIGD7 SNHG19 ENSG00000261240
GH16H002903 1.9 FANTOM5 Ensembl ENCODE dbSUPER 15.6 -6.3 -6314 4 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF548 CREBBP ZNF597 ZNF263 ZNF174 ENSG00000261938 TBL3 ZNF75A TSC2 FLYWCH2 E4F1
GH16H002926 1.2 Ensembl ENCODE 21.7 +15.5 15460 1.7 ATF1 ARNT ARID4B BRCA1 ZNF2 YY1 ZNF143 KLF7 ATF7 RUNX3 FLYWCH1 KREMEN2 PAQR4 PKMYT1 SRRM2-AS1 PRSS27 ENSG00000255513 LOC107984895 GC16P002923 GC16P002955
GH16H002602 2.4 ENCODE dbSUPER 10.4 -308.3 -308305 1.7 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A PPARGC1A SSRP1 TBL3 ZNF597 AMDHD2 ENSG00000226890 SRRM2 ENSG00000200059 TIGD7 ZNF263 ENSG00000261240 ZNF598
GH16H003156 1.7 FANTOM5 ENCODE dbSUPER 10.4 +246.9 246873 3.8 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 ZNF207 ZNF75A ZNF213-AS1 ZNF205 E4F1 CREBBP ENSG00000261938 RNPS1 PDPK2P LOC652276 MTCO1P28
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FLYWCH1 on UCSC Golden Path with GeneCards custom track

Promoters for FLYWCH1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082563 279 1601 HDGF FOXA2 PKNOX1 ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF766 ZNF143

Genomic Locations for FLYWCH1 Gene

Genomic Locations for FLYWCH1 Gene
chr16:2,911,921-2,951,208
(GRCh38/hg38)
Size:
39,288 bases
Orientation:
Plus strand
chr16:2,961,938-3,001,209
(GRCh37/hg19)

Genomic View for FLYWCH1 Gene

Genes around FLYWCH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FLYWCH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FLYWCH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FLYWCH1 Gene

Proteins for FLYWCH1 Gene

  • Protein details for FLYWCH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4VC44-FWCH1_HUMAN
    Recommended name:
    FLYWCH-type zinc finger-containing protein 1
    Protein Accession:
    Q4VC44
    Secondary Accessions:
    • D3DUA1
    • Q6ZSQ1
    • Q8WV62
    • Q9BQG6
    • Q9BUS5
    • Q9HCM0

    Protein attributes for FLYWCH1 Gene

    Size:
    716 amino acids
    Molecular mass:
    80108 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13378.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FLYWCH1 Gene

    Alternative splice isoforms for FLYWCH1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FLYWCH1 Gene

Post-translational modifications for FLYWCH1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FLYWCH1 Gene

Domains & Families for FLYWCH1 Gene

Gene Families for FLYWCH1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FLYWCH1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FLYWCH1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FLYWCH1: view

No data available for UniProtKB/Swiss-Prot for FLYWCH1 Gene

Function for FLYWCH1 Gene

Phenotypes From GWAS Catalog for FLYWCH1 Gene

Gene Ontology (GO) - Molecular Function for FLYWCH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FLYWCH1: view
genes like me logo Genes that share phenotypes with FLYWCH1: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FLYWCH1 Gene

Localization for FLYWCH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLYWCH1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FLYWCH1 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (4)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FLYWCH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with FLYWCH1: view

Pathways & Interactions for FLYWCH1 Gene

SuperPathways for FLYWCH1 Gene

No Data Available

Interacting Proteins for FLYWCH1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000399938%0d%0a9606.ENSP00000218364%0d%0a
Selected Interacting proteins: Q4VC44-FWCH1_HUMAN ENSP00000399938 for FLYWCH1 Gene via IID MINT STRING

Gene Ontology (GO) - Biological Process for FLYWCH1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FLYWCH1 Gene

Drugs & Compounds for FLYWCH1 Gene

No Compound Related Data Available

Transcripts for FLYWCH1 Gene

Unigene Clusters for FLYWCH1 Gene

FLYWCH-type zinc finger 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FLYWCH1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - - - -
SP2: - - - -
SP3: -
SP4: -
SP5: -
SP6: -

Relevant External Links for FLYWCH1 Gene

GeneLoc Exon Structure for
FLYWCH1
ECgene alternative splicing isoforms for
FLYWCH1

Expression for FLYWCH1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FLYWCH1 Gene

Protein differential expression in normal tissues from HIPED for FLYWCH1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FLYWCH1 Gene



Protein tissue co-expression partners for FLYWCH1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FLYWCH1 Gene:

FLYWCH1

SOURCE GeneReport for Unigene cluster for FLYWCH1 Gene:

Hs.655321

Evidence on tissue expression from TISSUES for FLYWCH1 Gene

  • Eye(4.5)
  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with FLYWCH1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FLYWCH1 Gene

Orthologs for FLYWCH1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FLYWCH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FLYWCH1 33 34
  • 98.83 (n)
cow
(Bos Taurus)
Mammalia FLYWCH1 33 34
  • 83.73 (n)
dog
(Canis familiaris)
Mammalia FLYWCH1 33 34
  • 83.68 (n)
rat
(Rattus norvegicus)
Mammalia Flywch1 33
  • 79.06 (n)
mouse
(Mus musculus)
Mammalia Flywch1 33 16 34
  • 76.44 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 24 (a)
OneToMany
Species where no ortholog for FLYWCH1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FLYWCH1 Gene

ENSEMBL:
Gene Tree for FLYWCH1 (if available)
TreeFam:
Gene Tree for FLYWCH1 (if available)

Paralogs for FLYWCH1 Gene

Paralogs for FLYWCH1 Gene

(1) SIMAP similar genes for FLYWCH1 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for FLYWCH1 Gene

genes like me logo Genes that share paralogs with FLYWCH1: view

Variants for FLYWCH1 Gene

Sequence variations from dbSNP and Humsavar for FLYWCH1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000041829 -- 2,917,957(+) CTCAG(A/C)CTCCT intron-variant
rs1000186042 -- 2,951,333(+) CCTAG(-/CCT)CCTGT intron-variant, downstream-variant-500B
rs1000240596 -- 2,917,836(+) ATCTG(C/G/T)AGTCT intron-variant
rs1000280817 -- 2,932,327(+) TTTGG(G/T)TCCTA intron-variant
rs1000297428 -- 2,917,529(+) CGGCC(A/G)TTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FLYWCH1 Gene

Variant ID Type Subtype PubMed ID
nsv977105 CNV duplication 23825009
nsv952906 CNV deletion 24416366
nsv833124 CNV loss 17160897
nsv827524 CNV loss 20364138
nsv819421 CNV loss 19587683
nsv571247 CNV loss 21841781
nsv571246 CNV loss 21841781
nsv571245 CNV loss 21841781
nsv510673 CNV deletion 20534489
nsv509588 CNV insertion 20534489
nsv1070314 CNV deletion 25765185
esv3637644 CNV loss 21293372
esv3637643 CNV loss 21293372
esv3637642 CNV loss 21293372
esv3637641 CNV loss 21293372
esv29718 CNV gain 19812545
esv29676 CNV loss 19812545
esv2750387 CNV deletion 23290073
esv2671794 CNV deletion 23128226
esv2667921 CNV deletion 23128226

Variation tolerance for FLYWCH1 Gene

Residual Variation Intolerance Score: 99.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.99; 60.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FLYWCH1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FLYWCH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLYWCH1 Gene

Disorders for FLYWCH1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FLYWCH1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
parenchymatous neurosyphilis
tertiary neurosyphilis
  • late neurosyphilis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FLYWCH1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FLYWCH1
genes like me logo Genes that share disorders with FLYWCH1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FLYWCH1 Gene

Publications for FLYWCH1 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 60
  2. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X … Chen J (Molecular systems biology 2015) 3 60

Products for FLYWCH1 Gene

Sources for FLYWCH1 Gene

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