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Aliases for FLYWCH1 Gene

Aliases for FLYWCH1 Gene

  • FLYWCH-Type Zinc Finger 1 2 3
  • KIAA1552 4

External Ids for FLYWCH1 Gene

Summaries for FLYWCH1 Gene

GeneCards Summary for FLYWCH1 Gene

FLYWCH1 (FLYWCH-Type Zinc Finger 1) is a Protein Coding gene. An important paralog of this gene is FLYWCH2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLYWCH1 Gene

Genomics for FLYWCH1 Gene

Genomic Location for FLYWCH1 Gene

Start:
2,911,937 bp from pter
End:
2,951,208 bp from pter
Size:
39,272 bases
Orientation:
Plus strand

Genomic View for FLYWCH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FLYWCH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FLYWCH1 Gene

Regulatory Elements for FLYWCH1 Gene

Proteins for FLYWCH1 Gene

  • Protein details for FLYWCH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4VC44-FWCH1_HUMAN
    Recommended name:
    FLYWCH-type zinc finger-containing protein 1
    Protein Accession:
    Q4VC44
    Secondary Accessions:
    • D3DUA1
    • Q6ZSQ1
    • Q8WV62
    • Q9BQG6
    • Q9BUS5
    • Q9HCM0

    Protein attributes for FLYWCH1 Gene

    Size:
    716 amino acids
    Molecular mass:
    80108 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13378.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FLYWCH1 Gene

    Alternative splice isoforms for FLYWCH1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FLYWCH1 Gene

Proteomics data for FLYWCH1 Gene at MOPED

Post-translational modifications for FLYWCH1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FLYWCH1 Gene

Domains for FLYWCH1 Gene

Gene Families for FLYWCH1 Gene

HGNC:

Protein Domains for FLYWCH1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FLYWCH1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4VC44

UniProtKB/Swiss-Prot:

FWCH1_HUMAN
Similarity:
  • Contains 5 FLYWCH-type zinc fingers.:
    • Q4VC44
genes like me logo Genes that share domains with FLYWCH1: view

Function for FLYWCH1 Gene

Gene Ontology (GO) - Molecular Function for FLYWCH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FLYWCH1: view

Phenotypes for FLYWCH1 Gene

GenomeRNAi human phenotypes for FLYWCH1:
genes like me logo Genes that share phenotypes with FLYWCH1: view

miRNA for FLYWCH1 Gene

miRTarBase miRNAs that target FLYWCH1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FLYWCH1 Gene

Localization for FLYWCH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLYWCH1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FLYWCH1 Gene COMPARTMENTS Subcellular localization image for FLYWCH1 gene
Compartment Confidence
cytosol 4
nucleus 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FLYWCH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with FLYWCH1: view

Pathways for FLYWCH1 Gene

SuperPathways for FLYWCH1 Gene

No Data Available

Interacting Proteins for FLYWCH1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000399938%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000334499%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000399938 Q4VC44-FWCH1_HUMAN for FLYWCH1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for FLYWCH1 Gene

None

No data available for Pathways by source for FLYWCH1 Gene

Transcripts for FLYWCH1 Gene

Unigene Clusters for FLYWCH1 Gene

FLYWCH-type zinc finger 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FLYWCH1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - - - -
SP2: - - - -
SP3: -
SP4: -
SP5: -
SP6: -

Relevant External Links for FLYWCH1 Gene

GeneLoc Exon Structure for
FLYWCH1
ECgene alternative splicing isoforms for
FLYWCH1

Expression for FLYWCH1 Gene

mRNA expression in normal human tissues for FLYWCH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FLYWCH1 Gene

SOURCE GeneReport for Unigene cluster for FLYWCH1 Gene Hs.655321

genes like me logo Genes that share expressions with FLYWCH1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FLYWCH1 Gene

Orthologs for FLYWCH1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FLYWCH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FLYWCH1 35
  • 98.83 (n)
  • 98.39 (a)
FLYWCH1 36
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FLYWCH1 35
  • 83.73 (n)
  • 78.56 (a)
FLYWCH1 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FLYWCH1 35
  • 83.68 (n)
  • 81.01 (a)
FLYWCH1 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Flywch1 35
  • 76.44 (n)
  • 72.85 (a)
Flywch1 16
Flywch1 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 24 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Flywch1 35
  • 79.06 (n)
  • 75.48 (a)
Species with no ortholog for FLYWCH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FLYWCH1 Gene

ENSEMBL:
Gene Tree for FLYWCH1 (if available)
TreeFam:
Gene Tree for FLYWCH1 (if available)

Paralogs for FLYWCH1 Gene

Paralogs for FLYWCH1 Gene

Selected SIMAP similar genes for FLYWCH1 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for FLYWCH1 Gene

genes like me logo Genes that share paralogs with FLYWCH1: view

Variants for FLYWCH1 Gene

Sequence variations from dbSNP and Humsavar for FLYWCH1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs734138 -- 2,949,217(+) AATCT(C/T)TTCTG utr-variant-3-prime
rs739716 -- 2,936,430(-) GTGGA(A/G)CTACC intron-variant
rs739795 -- 2,950,525(+) CCTGA(A/G)TCACT utr-variant-3-prime
rs739796 -- 2,950,673(+) GAGGC(A/G)AATCA utr-variant-3-prime
rs757164 -- 2,913,527(-) CACAC(A/G)TTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FLYWCH1 Gene

Variant ID Type Subtype PubMed ID
nsv905152 CNV Loss 21882294
nsv905162 CNV Gain 21882294
nsv905165 CNV Loss 21882294
nsv905169 CNV Loss 21882294
nsv905170 CNV Loss 21882294
dgv2574n71 CNV Loss 21882294
dgv2575n71 CNV Loss 21882294
nsv833124 CNV Loss 17160897
esv2667921 CNV Deletion 23128226
nsv905181 CNV Loss 21882294
dgv2576n71 CNV Loss 21882294
nsv509588 CNV Insertion 20534489
nsv510673 CNV Loss 20534489
esv29676 CNV Loss 19812545
nsv905185 CNV Loss 21882294
esv2671794 CNV Deletion 23128226
esv2750387 CNV Deletion 23290073
esv29718 CNV Gain 19812545
nsv827524 CNV Loss 20364138
nsv819421 CNV Loss 19587683

Relevant External Links for FLYWCH1 Gene

HapMap Linkage Disequilibrium report
FLYWCH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLYWCH1 Gene

Disorders for FLYWCH1 Gene

No disorders were found for FLYWCH1 Gene.

No data available for UniProtKB/Swiss-Prot for FLYWCH1 Gene

Publications for FLYWCH1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Evolution of the trans-splicing Drosophila locus mod(mdg4) in several species of Diptera and Lepidoptera. (PMID: 15094203) Krauss V. … Dorn R. (Gene 2004) 3
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3

Products for FLYWCH1 Gene

Sources for FLYWCH1 Gene

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