FLYWCH1 Gene
protein-coding GIFtS: 45
GCID: GC16P002935
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FLYWCH-type zinc finger 1
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Aliases
for FLYWCH1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| FLYWCH-Type Zinc Finger 11 2 | | DKFZp761A1321 | | FLYWCH-Type Zinc Finger-Containing Protein 12 | | KIAA15523 |
Export aliases for FLYWCH1 gene to outside databasesPrevious GC identifers: GC16P002902 GC16P002961 |
Summaries
for FLYWCH1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FLYWCH1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FLYWCH1 gene promoter:
CREB Spz1 Elk-1 deltaCREB HSF1short HSF1 (long) LUN-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FLYWCH1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FLYWCH1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3FLYWCH1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P002935: view genomic region
(about GC identifiers)
Start:
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2,961,938 bp from pter |
End:
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3,001,209 bp from pter |
Size:
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39,272 bases |
Orientation:
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plus strand |
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Proteins
for FLYWCH1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FWCH1_HUMAN, Q4VC44 (See
protein sequence)Recommended Name: FLYWCH-type zinc finger-containing protein 1 Size: 716 amino acids; 80108 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAB13378.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from  and Proteopedia  for FLYWCH1:2RPR (3D)
Secondary accessions: D3DUA1 Q6ZSQ1 Q8WV62 Q9BQG6 Q9BUS5 Q9HCM0Alternative splicing: 5 isoforms: Q4VC44-1 Q4VC44-2 Q4VC44-3 Q4VC44-4 Q4VC44-5 Explore the universe of human proteins at neXtProt for FLYWCH1: NX_Q4VC44
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q4VC44
FLYWCH1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_065963.1 NP_115672.2
ENSEMBL proteins: ENSP00000253928 ENSP00000399938 ENSP00000458282 ENSP00000459326 ENSP00000458661 ENSP00000344122 ENSP00000461566 ENSP00000458689 ENSP00000459480 ENSP00000382575
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
FLYWCH1 for ontologies About GeneDecksing
FLYWCH1 Antibody Products:
Assay Products for FLYWCH1: |
Protein
Domains /
Families
for FLYWCH1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FLYWCH1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q4VC44ProtoNet protein and cluster: Q4VC44 UniProtKB/Swiss-Prot: FWCH1_HUMAN, Q4VC44Similarity: Contains 5 FLYWCH-type zinc fingers |
Function
for FLYWCH1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FLYWCH1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FLYWCH1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): FLYWCH1 (NM_032296) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FLYWCH1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLYWCH1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLYWCH1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
FLYWCH1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for FLYWCH1:
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Pathways & Interactions
for FLYWCH1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FLYWCH1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
4 Interacting proteins for FLYWCH1 (Q4VC443 ENSP000003999384) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FLYWCH1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FLYWCH1
Search CenterWatch for drugs/clinical trials and news about FLYWCH1 / FWCH1
|
Transcripts
for FLYWCH1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FLYWCH1 gene (2 alternative transcripts): NM_020912.1 NM_032296.2 Unigene Cluster for FLYWCH1: FLYWCH-type zinc finger 1 Hs.655321 [show with all ESTs]Unigene Representative Sequence: NM_03229615 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000253928(uc002csb.3 uc002csc.3 uc002csd.3 uc002cse.3)
ENST00000571140 ENST00000416288 ENST00000570425 ENST00000573525 ENST00000570759
ENST00000573564 ENST00000344592 ENST00000571580 ENST00000575604 ENST00000570752
ENST00000574985 ENST00000571983 ENST00000575679 ENST00000399667(uc010bsv.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FLYWCH1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FLYWCH1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FLYWCH1 (NM_032296) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FLYWCH1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLYWCH1 |
Additional cDNA sequence: AB046772.1 AK026885.1 AK092434.1 AL136585.1 BC001973.1 BC018712.1 BC028572.1 9 DOTS entries: DT.211342 DT.100791607 DT.95171907 DT.40286968 DT.95080341 DT.97847195 DT.75197110 DT.100018205 DT.120670877 24/298 AceView cDNA sequences (see all 298): BM918403 BM785027 CD722400 BM466621 BU902079 BM705997 BU857650 CD672241 BM562651 CR601271 CD107657 CA454125 BM693039 CD674036 BM715166 CD671260 BM557693 NM_032296 BM784140 AA284150 AA910072 BX355080 AA401452 BM661807
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FLYWCH1 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b |
|---|
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| SP1: | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP5: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FLYWCH1
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Expression
for FLYWCH1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FLYWCH1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACTGCAAGG
About this image
See FLYWCH1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FLYWCH1
SOURCE GeneReport for Unigene cluster: Hs.655321
SABiosciences Custom PCR Arrays for FLYWCH1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FLYWCH1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FLYWCH1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FLYWCH1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FLYWCH1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLYWCH1 |
Orthologs
for FLYWCH1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for FLYWCH1 gene from 1/6 species (see all 6) About this table
ENSEMBL Gene Tree for FLYWCH1 (if available)
TreeFam Gene Tree for FLYWCH1 (if available) |
Paralogs
for FLYWCH1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FLYWCH1 gene
- FLYWCH22
1 SIMAP similar gene for FLYWCH1 using alignment to 8 protein entries: FWCH1_HUMAN (see all proteins):FLYWCH2
FLYWCH1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for FLYWCH1
PGOHUM00000237881
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Genomic Variants
for FLYWCH1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FLYWCH1 (2961938 - 3001209 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for FLYWCH1
2 CNVs: 4920 66921
2 Indels: 58752 72427 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FLYWCH1 |
|
Disorders
/ Diseases
for FLYWCH1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FLYWCH1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FLYWCH1 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with FLYWCH1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
- Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2, 3 Nagase T.... Ohara O. (2000)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- Evolution of the trans-splicing Drosophila locus mod( mdg4) in several species of Diptera and Lepidoptera. (PubMed id 15094203)1 Krauss V. and Dorn R. (2004)
|
External Searches for FLYWCH1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FLYWCH1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FLYWCH1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing FLYWCH1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FLYWCH1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FLYWCH1 gene:
Search GeneIP for patents involving FLYWCH1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FLYWCH1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | FLYWCH1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLYWCH1 |
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