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FLVCR2 Gene

protein-coding   GIFtS: 51
GCID: GC14P076045

Feline Leukemia Virus Subgroup C Cellular Receptor Family,...

(Previous names: chromosome 14 open reading frame 58, feline leukemia virus...)
(Previous symbol: C14orf58)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Feline Leukemia Virus Subgroup C Cellular Receptor Family, Member 21 2     Chromosome 14 Open Reading Frame 581
C14orf581 2 3 5     Feline Leukemia Virus Subgroup C Cellular Receptor 21
CCT2 3 5     FLVCRL14q2
Calcium-Chelate Transporter2 3     MFSD7C2
EPV2 5     Feline Leukemia Virus Subgroup C Receptor-Related Protein 22
PVHH2 5     

External Ids:    HGNC: 201051   Entrez Gene: 556402   Ensembl: ENSG000001196867   OMIM: 6108655   UniProtKB: Q9UPI33   

Export aliases for FLVCR2 gene to outside databases

Previous GC identifers: GC14P075115 GC14P056212


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FLVCR2 Gene:
This gene encodes a member of the major facilitator superfamily. The encoded transmembrane protein is a calcium
transporter. Unlike the related protein feline leukemia virus subgroup C receptor 1, the protein encoded by this
locus does not bind to feline leukemia virus subgroup C envelope protein. The encoded protein may play a role in
development of brain vascular endothelial cells, as mutations at this locus have been associated with
proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Alternatively spliced transcript variants
have been described.(provided by RefSeq, Aug 2010)

GeneCards Summary for FLVCR2 Gene:
FLVCR2 (feline leukemia virus subgroup C cellular receptor family, member 2) is a protein-coding gene. Diseases associated with FLVCR2 include proliferative vasculopathy and hydraencephaly-hydrocephaly syndrome, and fowler's syndrome. GO annotations related to this gene include heme transporter activity and heme binding. An important paralog of this gene is MFSD7.

UniProtKB/Swiss-Prot: FLVC2_HUMAN, Q9UPI3
Function: Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for
growth and calcium metabolism




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the FLVCR2 gene promoter:
         ER-alpha   AhR   c-Fos   AP-1   Olf-1   POU3F2   Arnt   C/EBPalpha   AREB6   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFLVCR2 promoter sequence
   Search Chromatin IP Primers for FLVCR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FLVCR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.3

FLVCR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FLVCR2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P076045:  view genomic region     (about GC identifiers)

Start:
76,044,940 bp from pter      End:
76,129,557 bp from pter
Size:
84,618 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FLVC2_HUMAN, Q9UPI3 (See protein sequence)
Recommended Name: Feline leukemia virus subgroup C receptor-related protein 2  
Size: 526 amino acids; 57241 Da
Sequence caution: Sequence=BAB55381.1; Type=Erroneous initiation;
Secondary accessions: B7Z485 Q53ZT9 Q96JY3 Q9NX90
Alternative splicing: 2 isoforms:  Q9UPI3-1   Q9UPI3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FLVCR2: NX_Q9UPI3

Explore proteomics data for FLVCR2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FLVCR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001182212.1  NP_060261.2  

    ENSEMBL proteins: 
     ENSP00000238667   ENSP00000443439   ENSP00000451104   ENSP00000452584   ENSP00000451603  
     ENSP00000452468   ENSP00000451781   ENSP00000452453  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Feline leukemia virus subgroup C cellular receptor family, member 2
    SLC49 family of FLVCR-related haem transporters

    3 InterPro protein domains:
     IPR011701 MFS
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q9UPI3

    ProtoNet protein and cluster: Q9UPI3

    UniProtKB/Swiss-Prot: FLVC2_HUMAN, Q9UPI3
    Similarity: Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor (TC
    2.A.1.28.1) family


    FLVCR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FLVC2_HUMAN, Q9UPI3
    Function: Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for
    growth and calcium metabolism

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015232heme transporter activity IDA--
    GO:0020037heme binding IDA--
         
    FLVCR2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FLVCR2:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FLVCR2
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    miRNA
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    Block miRNA regulation of human, mouse, rat FLVCR2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FLVCR2 (see all 25):
    hsa-miR-30c hsa-miR-548j hsa-miR-125a-5p hsa-miR-137 hsa-miR-548i hsa-miR-30d hsa-miR-30a hsa-miR-125b
    SwitchGear 3'UTR luciferase reporter plasmidFLVCR2 3' UTR sequence
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FLVC2_HUMAN, Q9UPI3: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    FLVCR2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FLVCR2
    Interactions:

        Search GeneGlobe Interaction Network for FLVCR2

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015886heme transport IDA--
    GO:0055085transmembrane transport IEA--

    FLVCR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FLVCR2 (FLVC2)

    1 HMDB Compound for FLVCR2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 Novoseek inferred chemical compound relationship for FLVCR2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 56 40 17321497 (2), 17979693 (2), 2156817 (2), 8273213 (1) (see all 19)



    FLVCR2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FLVCR2 gene (2 alternative transcripts): 
    NM_001195283.1  NM_017791.2  

    Unigene Clusters for FLVCR2:

    Feline leukemia virus subgroup C cellular receptor family, member 2
    Hs.509966  [show with all ESTs], Hs.615289
    Unigene Representative Sequences: NM_017791, BC001448
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000238667(uc001xrs.2 uc010tvd.1) ENST00000554496 ENST00000555385
    ENST00000539311 ENST00000555058 ENST00000553341 ENST00000556241 ENST00000553587
    ENST00000556856 ENST00000554580 ENST00000555027 ENST00000556409 ENST00000556745

    miRNA
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    Block miRNA regulation of human, mouse, rat FLVCR2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FLVCR2 (see all 25):
    hsa-miR-30c hsa-miR-548j hsa-miR-125a-5p hsa-miR-137 hsa-miR-548i hsa-miR-30d hsa-miR-30a hsa-miR-125b
    SwitchGear 3'UTR luciferase reporter plasmidFLVCR2 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat FLVCR2
      QuantiFast Probe-based Assays in human, mouse, rat FLVCR2

    Additional mRNA sequence: BC001448.2 

    5 DOTS entries:

    DT.313660  DT.100721865  DT.100695772  DT.91815267  DT.120752774 

    5 AceView cDNA sequences:

    CD674973 AL049169 BE281496 BC001448 BE281518 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FLVCR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTTTACA
    FLVCR2 Expression
    About this image


    FLVCR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Gonad
             Primordial Germ Cells Allantois
     
     Placenta (Extraembryonic Tissues)
             Primordial Germ Cells Allantois
     
     Spleen (Hematopoietic System)
    FLVCR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FLVCR2 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.509966 Hs.615289

    UniProtKB/Swiss-Prot: FLVC2_HUMAN, Q9UPI3
    Tissue specificity: Expressed in non-hematopoietic tissues, with relative abundant expression in brain, placenta,
    lung, liver and kidney. Also expressed in hematopoietic tissues (fetal liver, spleen, lymph node, thymus,
    leukocytes and bone marrow). Found in acidophil cells of the pituitary that secrete growth hormone and prolactin

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FLVCR2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mfsd7c1 , 5 major facilitator superfamily domain containing 7C1, 5 86.7(n)1
    86.83(a)1
      12 (39.80 cM)5
    2177211  NM_145447.21  NP_663422.11 
     857465395 
    chicken
    (Gallus gallus)
    Aves FLVCR21 feline leukemia virus subgroup C cellular receptor more 72.33(n)
    74.5(a)
      423365  XM_421280.4  XP_421280.3 
    lizard
    (Anolis carolinensis)
    Reptilia FLVCR26
    feline leukemia virus subgroup C cellular receptor...
    70(a)
    1 ↔ 1
    1(22218683-22266359)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA985348.12   -- 74.42(n)    CA985348.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570458692   -- 70.16(n)    57045869 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG13586
    --
    47(a)
    1 → many
    2R(3483240-3508216)
    worm
    (Caenorhabditis elegans)
    Secernentea C09D4.16
    Protein C09D4.1, isoform a
    38(a)
    1 → many
    I(5497778-5505385) WBGene00015632


    ENSEMBL Gene Tree for FLVCR2 (if available)
    TreeFam Gene Tree for FLVCR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FLVCR2 gene
    MFSD72  FLVCR12  DIRC22  
    1 SIMAP similar gene for FLVCR2 using alignment to 7 protein entries:     FLVC2_HUMAN (see all proteins):
    FLVCR1

    FLVCR2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FLVCR2 (see all 1428)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0644124
    Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH)4--see VAR_0644122 A V mis40--------
    VAR_0640454
    Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH)4--see VAR_0640452 T R mis40--------
    VAR_0640444
    Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH)4--see VAR_0640442 L V mis40--------
    VAR_0644134
    Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH)4--see VAR_0644132 T R mis40--------
    VAR_0640434
    Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH)4--see VAR_0640432 P R mis40--------
    VAR_0644144
    Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH)4--see VAR_0644142 G R mis40--------
    VAR_0644154
    Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH)4--see VAR_0644152 T M mis40--------
    VAR_0644104
    Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH)4--see VAR_0644102 R H mis40--------
    rs1384957051,2
    Cpathogenic157031780(+) TGGCTA/C/TGGCTC 2 * S stg10--------
    rs114557361,2
    C--56259388(+) AAAAAT/-TTTTT 2 -- int12Minor allele frequency- -:0.25NA CSA 4

    HapMap Linkage Disequilibrium report for FLVCR2 (76044940 - 76129557 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FLVCR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670064CNV Deletion23128226
    nsv456342CNV Loss19166990

    Human Gene Mutation Database (HGMD): FLVCR2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FLVCR2
    DNA2.0 Custom Variant and Variant Library Synthesis for FLVCR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610865   
    OMIM disorders: 225790  
    UniProtKB/Swiss-Prot: FLVC2_HUMAN, Q9UPI3
  • Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH) [MIM:225790]: A rare
    prenatally lethal disorder characterized by hydranencephaly, a distinctive glomerular vasculopathy in the central
    nervous system and retina, and diffuse ischemic lesions of the brain stem, basal ganglia, and spinal cord with
    calcifications. Hydranencephaly is a condition where the greater portions of the cerebral hemispheres and corpus
    striatum are replaced by cerebrospinal fluid and glial tissue. Note=The disease is caused by mutations affecting
    the gene represented in this entry

  • 16 diseases for FLVCR2:    
    About MalaCards
    proliferative vasculopathy and hydraencephaly-hydrocephaly syndrome    fowler's syndrome    proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome    hydranencephaly
    central pontine myelinolysis    ischemic optic neuropathy    leukemia    endotheliitis
    neuropathy    cerebritis    retinitis    breast cancer
    multiple myeloma    myeloma    malaria    neuronitis

    3 diseases from the University of Copenhagen DISEASES database for FLVCR2:
    Hydranencephaly     Dissociative disorder     Central pontine myelinolysis

    FLVCR2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for FLVCR2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 0 2 16410040 (1), 17321497 (1)

    Genetic Association Database (GAD): FLVCR2

    Export disorders for FLVCR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FLVCR2 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with FLVCR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in FLVCR2 are associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (Fowler syndrome). (PubMed id 20206334)1, 2, 3 Meyer E.... Maher E.R. (Am. J. Hum. Genet. 2010)
    2. The Fowler syndrome-associated protein FLVCR2 is an importer of heme. (PubMed id 20823265)1, 2 Duffy S.P....Tailor C.S. (Mol. Cell. Biol. 2010)
    3. High-throughput sequencing of a 4.1 Mb linkage interval reveals FLVCR2 deletions and mutations in lethal cerebral vasculopathy. (PubMed id 20690116)1, 2 Thomas S.... Attie-Bitach T. (Hum. Mutat. 2010)
    4. Comprehensive mapping of receptor-functioning domains in feline leukemia virus subgroup C receptor FLVCR1. (PubMed id 16439531)1, 3 Brown J.K....Tailor C.S. (J. Virol. 2006)
    5. Novel hexad repeats conserved in a putative transporter with restricted expression in cell types associated with growth, calcium exchange and homeostasis. (PubMed id 14729055)1, 2 Brasier G.... Wookey P.J. (Exp. Cell Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (Nature 2003)
    9. Unexpected allelic heterogeneity and spectrum of mutations in Fowler syndrome revealed by next-generation exome sequencing. (PubMed id 20518025)2 Lalonde E.... Jabado N. (Hum. Mutat. 2010)
    10. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (PLoS ONE 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55640 HGNC: 20105 AceView: C14orf58.1 Ensembl:ENSG00000119686 euGenes: HUgn55640
    ECgene: FLVCR2 H-InvDB: FLVCR2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FLVCR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FLVCR2 gene:
    Search GeneIP for patents involving FLVCR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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