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FLVCR1 Gene

protein-coding   GIFtS: 50

GC01P211099
feline leukemia virus subgroup C cellular receptor 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLVCR 1, 2, 3
OTTHUMP00000035011 2
hFLVCR 3
Descriptions
Feline leukemia virus subgroup C receptor 3
feline leukemia virus subgroup C cellular receptor 1 2
External Ids
HGNC: 246821
Entrez Gene: 289822
UniProtKB: Q9Y5Y03
Ensembl: ENSG000001627697
Search outside databases for aliases for FLVCR1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: FLVC1_HUMAN, Q9Y5Y0
Function: Exports cytoplasmic heme. May be required to protect developing erythroid cells from heme
toxicity. Causes susceptibility to FeLV-C in vitro

Gene Wiki entry for FLVCR1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.3   Ensembl cytogenetic band:  1q32.3   HGNC cytogenetic band: 1q32.3

FLVCR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P211099:     (about GC identifiers)

Start:
211,098,220 bp from pter
End:
211,135,379 bp from pter
Size:
37,160 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000001.9  NT_021877.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: FLVC1_HUMAN, Q9Y5Y0 (See protein sequence)
Recommended Name: Feline leukemia virus subgroup C receptor-related protein 1  
Size: 555 amino acids; 59863 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity)
Developmental stage: Down-regulated in haemopoietic progenitor cells undergoing differentiation and
hemoglobinization. Abundant in fetal liver
Secondary accessions: Q86XY9 Q9NVR9

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_054772.1  

    ENSEMBL proteins: 
    ENSP00000355938 


    Human Recombinant Proteins 
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    Recombinant Proteins from Abcam (FLVCR)
    Human Recombinant Proteins from Abnova (FLVCR1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane IEA--
    GO:0005887 integral to plasma membrane TAS10648427
    About this table

    Antibodies for FLVCR1: 
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    Novus Biologicals Antibodies for FLVCR1

    Assays for FLVCR1: 
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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR011701 MFS_1


       GeneDecks  FLVCR1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9Y5Y0

    ProtoNet protein and cluster: Q9Y5Y0

    UniProtKB/Swiss-Prot: FLVC1_HUMAN, Q9Y5Y0
    Similarity: Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor
    (TC 2.A.1.28.1) family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (FLVCR1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (FLVCR1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014053

                  Applied Biosystems Silencer® siRNAs for FLVCR1

                  Sigma-Aldrich siRNA and siRNA Panels for FLVCR1  
                         Sigma-Aldrich shRNA for FLVCR1  
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    Clones:Invitrogen Clones for FLVCR1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_014053
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_014053
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_014053 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_014053

    UniProtKB/Swiss-Prot: FLVC1_HUMAN, Q9Y5Y0
    Function: Exports cytoplasmic heme. May be required to protect developing erythroid cells from heme
    toxicity. Causes susceptibility to FeLV-C in vitro

    11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mfsd7b):

    craniofacialgrowth/sizehematopoietic systemimmune system
    lethality-prenatal/perinatallimbs/digits/tailnormalrenal/urinary systemreproductive system
    respiratory system

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872 receptor activity IEA--
    GO:0005215 transporter activity TAS10648427
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    1 Interacting protein for FLVCR1 (ENSP000003559383) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000198468ENSP000003491123STRING (score=.802)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810 transport TAS10648427
    GO:0007275 multicellular organismal development TAS10648427
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for FLVCR1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (FLVCR1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (FLVCR1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014053

                  Sigma-Aldrich siRNA and siRNA Panels for FLVCR1  
                         Sigma-Aldrich shRNA for FLVCR1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_014053  

    REFSEQ mRNAs for FLVCR1 gene: 

    NM_014053.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_014053  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_014053
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_014053
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_014053 

    Additional cDNA sequence: 

    AF118637.1 AK001419.1 AK314481.1 BC048312.1 

    6 DOTS entries:

    DT.439109  DT.91723542  DT.40130704  DT.91723544  DT.100008065  DT.40273750 

    24/42 AceView cDNA sequences (see all 42 ):

    BX462585 AK001419 BQ694102 AI360630 BC048312 AU148769 N78572 AU128008 
    AU124525 AA305281 AW188435 BG283988 BX115707 AF118637 CB121791 BG167060 
    NM_014053 BE904633 BE042762 BG116640 CA407434 AL582174 BQ957760 BG479760 

    Unigene Cluster for FLVCR1:

    Feline leukemia virus subgroup C cellular receptor 1
    Hs.7055  [show with all ESTs]
    Unigene Representative Sequence: NM_014053


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FLVCR1

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:              -           -     -     -                       -                                 
    SP2:              -           -     -     -     -                 -                                 
    SP3:                                      -                                                         
    SP4:                                                                                                

    About this scheme

    ECgene alternative splicing isoforms for FLVCR1

    1 Ensembl transcript including schematic representation:
    ENST00000366971  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    FLVCR1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for FLVCR1

    1 / 2

    3 probe-sets matching FLVCR1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    63468_at2 U95-C 1 0.88 1.00 1.00 1.00 -- -- -- -- --

    222906_at2 U133-B 1 0.91 1.00 -- -- -- -- -- -- --

    222906_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: ACTGGTTACC

    SOURCE GeneReport for Unigene cluster: Hs.7055

    UniProtKB/Swiss-Prot: FLVC1_HUMAN, Q9Y5Y0
    Tissue specificity: Found all hematopoietic tissues including peripheral blood lymphocytes. Some
    expression is found in pancreas and kidney

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for FLVCR1 gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    FLVCR11   -- feline leukemia virus subgroup C cellular receptor more 88.41(n)
    86.49(a)
    490285  XM_547405.2  XP_547405.2 
    chimpanzee
    (Pan troglodytes)
    FLVCR11   -- feline leukemia virus subgroup C cellular receptor more 99.52(n)
    99.82(a)
    457724  XM_514185.2  XP_514185.2 
    cow
    (Bos taurus)
    FLVCR11   -- feline leukemia virus subgroup C cellular receptor more 87.82(n)
    87.03(a)
    533317  XM_612690.3  XP_612690.3 
    mouse
    (Mus musculus)
    Mfsd7b1, 5 15
    major facilitator superfamily domain containing 7B1, 5 81.6(n)1
    80.99(a)1
    2268441  NM_001081259.11  NP_001074728.11 
     AA4156135  AI6437655  (see all 14)
    chicken
    (Gallus gallus)
    FLVCR11   -- feline leukemia virus subgroup C cellular receptor more 73.52(n)
    75.05(a)
    421365  XM_419425.2  XP_419425.2 
    About this table        Species with no ortholog for FLVCR1

    ENSEMBL Gene Tree for FLVCR1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for FLVCR1 gene
    MFSD72  FLVCR22  DIRC22  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/516 NCBI SNPs in FLVCR1 are shown (see all 516 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 108)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs10478811,2
    A,C,F,H,O211097781(-) AGGCAA/GCTGTG 1 -- ng5117Minor allele frequency- G:0.50MN EU EA WA NA NS 1538
    rs22016021,2
    A,C,F,H211098096(+) TCCCGA/CAGTTC 1 -- ng5113Minor allele frequency- C:0.49NA EA NS EU WA 1142
    rs66797751,2
    A,C,F,H211135608(+) AAGTGA/GTAATA 1 -- ng319Minor allele frequency- G:0.10NS EU EA WA 748
    --
    rs111200471,2
    A,C,F,H211098571(+) ATGGGG/CCCCCC 1 P/A mis110Minor allele frequency- C:0.47EU EA WA NA NS 806
    rs22209491,2
    A,C,F,H211097973(+) tccagC/TaacaC 1 -- ng5113Minor allele frequency- T:0.34EU EA WA NS 1212
    rs32070901,2
    A,C,F,H211135218(+) AAAAAC/TGGTTA 1 T/M mis116Minor allele frequency- T:0.41MN EU EA WA NA NS 1572
    rs120741921,2
    A,C,F,H211135594(+) TAGAAG/TACTTT 1 -- ng3112Minor allele frequency- T:0.30NA NS EU EA WA 890
    rs22016011,2
    A,C,F211098071(+) TCGCCG/CGCCGC 1 -- ng515Minor allele frequency- C:0.30NS 374
    rs37685541,2
    C,F,H211098031(-) GATGCA/GTGGCC 1 -- ng518Minor allele frequency- G:0.26EU EA WA 840
    rs170197801,2
    C,F,H211096437(+) ATACAC/GCTAGT 1 -- ng5116Minor allele frequency- G:0.07NA EU EA WA NS 1342
    About this table

    HapMap Linkage Disequilibrium images for FLVCR1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 609144

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/13 PubMed articles for FLVCR1 gene (see all 13 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 28982 HGNC: 24682 AceView: FLVCR Ensembl:ENSG00000162769 euGenes: HUgn28982
    ECgene: FLVCR1 H-InvDB: FLVCR1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for FLVCR1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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