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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FLVCR1 Gene

protein-coding   GIFtS: 57
GCID: GC01P213031

Feline Leukemia Virus Subgroup C Cellular Receptor 1

(Previous names: ataxia, posterior column 1, with retinitis pigmentosa)
(Previous symbol: AXPC1)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Feline Leukemia Virus Subgroup C Cellular Receptor 11 2     MFSD7B2
AXPC11 2 5     PCA2
FLVCR2 3     Feline Leukemia Virus Subgroup C Receptor-Related Protein 12
PCARP2 5     Feline Leukemia Virus Subgroup C Receptor3
Ataxia, Posterior Column 1, With Retinitis Pigmentosa1     hFLVCR3

External Ids:    HGNC: 246821   Entrez Gene: 289822   Ensembl: ENSG000001627697   OMIM: 6091445   UniProtKB: Q9Y5Y03   

Export aliases for FLVCR1 gene to outside databases

Previous GC identifers: GC01P211099 GC01P183708


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FLVCR1 Gene:
This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein is a
heme transporter that may play a critical role in erythropoiesis by protecting developing erythroid cells from
heme toxicity. This gene may play a role in posterior column ataxia with retinitis pigmentosa and the
hematological disorder Diamond-Blackfan syndrome. (provided by RefSeq, Jan 2011)

GeneCards Summary for FLVCR1 Gene: 
FLVCR1 (feline leukemia virus subgroup C cellular receptor 1) is a protein-coding gene. Diseases associated with FLVCR1 include posterior column ataxia, and posterior column ataxia with retinitis pigmentosa, and among its related super-pathways are Transferrin endocytosis and recycling and SLC-mediated transmembrane transport. GO annotations related to this gene include heme transporter activity and transporter activity. An important paralog of this gene is MFSD7.

UniProtKB/Swiss-Prot: FLVC1_HUMAN, Q9Y5Y0
Function: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX,
which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export
depends on the presence of HPX and may be required to protect developing erythroid cells from heme toxicity. Heme
export also provides protection from heme or ferrous iron toxicities in liver and brain. Causes susceptibility to
FeLV-C in vitro

Gene Wiki entry for FLVCR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_167186.1  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FLVCR1 gene promoter:
         NF-YA   C/EBPalpha   PPAR-gamma1   CBF-A   CBF-B   HOXA5   PPAR-gamma2   CP1A   NF-Y   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFLVCR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for FLVCR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FLVCR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.3   Ensembl cytogenetic band:  1q32.3   HGNC cytogenetic band: 1q32.3

FLVCR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FLVCR1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P213031:  view genomic region     (about GC identifiers)

Start:
213,031,597 bp from pter      End:
213,072,705 bp from pter
Size:
41,109 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FLVC1_HUMAN, Q9Y5Y0 (See protein sequence)
Recommended Name: Feline leukemia virus subgroup C receptor-related protein 1  
Size: 555 amino acids; 59863 Da
Subunit: Interacts with HPX
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity)
Developmental stage: Down-regulated in haemopoietic progenitor cells undergoing differentiation and
hemoglobinization. Abundant in fetal liver
Secondary accessions: Q1HE16 Q86XY9 Q9NVR9

Explore the universe of human proteins at neXtProt for FLVCR1: NX_Q9Y5Y0

Explore proteomics data for FLVCR1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y5Y0

  • FLVCR1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FLVCR1 Protein Expression
    REFSEQ proteins: NP_054772.1  
    ENSEMBL proteins: 
     ENSP00000355938   ENSP00000414680  
    Reactome Protein details: Q9Y5Y0
    Human Recombinant Protein Products for FLVCR1: 
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    Cloud-Clone Corp. Proteins for FLVCR1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS10648427
    GO:0016021integral to membrane ----
    GO:0031966mitochondrial membrane IEA--

    FLVCR1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Feline leukemia virus subgroup C cellular receptor family, member 1 
    SLC49 family of FLVCR-related haem transporters

    3 InterPro protein domains:
     IPR011701 MFS
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q9Y5Y0

    ProtoNet protein and cluster: Q9Y5Y0

    UniProtKB/Swiss-Prot: FLVC1_HUMAN, Q9Y5Y0
    Similarity: Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor (TC
    2.A.1.28.1) family


    FLVCR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FLVC1_HUMAN, Q9Y5Y0
    Function: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX,
    which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export
    depends on the presence of HPX and may be required to protect developing erythroid cells from heme toxicity. Heme
    export also provides protection from heme or ferrous iron toxicities in liver and brain. Causes susceptibility to
    FeLV-C in vitro

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity TAS10648427
    GO:0005515protein binding IPI--
    GO:0015232heme transporter activity IMP15369674
         
    FLVCR1 for ontologies           About GeneDecksing


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mfsd7b):
     cardiovascular system  craniofacial  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  mortality/aging  normal 
     renal/urinary system  reproductive system  respiratory system  skeleton 

    FLVCR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Mfsd7btm1.1Jlab for FLVCR1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FLVCR1 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FLVCR1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Insulin receptor recycling
    Iron uptake and transport0.69
    2SLC-mediated transmembrane transport
    Transmembrane transport of small molecules0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for FLVCR1
        Transmembrane transport of small molecules
    Iron uptake and transport



    FLVCR1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FLVCR1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for FLVCR1 (ENSP000003559384) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0006810transport TAS10648427
    GO:0006839mitochondrial transport IDA--
    GO:0006879cellular iron ion homeostasis TAS--
    GO:0007275multicellular organismal development TAS10648427

    FLVCR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FLVCR1 (FLVC1)

    1 HMDB Compound for FLVCR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--

    Search CenterWatch for drugs/clinical trials and news about FLVCR1 / FLVC1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FLVCR1 gene: 
    NM_014053.3  

    Unigene Cluster for FLVCR1:

    Feline leukemia virus subgroup C cellular receptor 1
    Hs.7055  [show with all ESTs]
    Unigene Representative Sequence: NM_014053
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366971(uc001hjt.3) ENST00000419102 ENST00000579295 ENST00000474693
    ENST00000483790

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    Additional mRNA sequence: 

    AF118637.1 AK001419.1 AK090739.1 AK314481.1 BC048312.1 

    8 DOTS entries:

    DT.215823  DT.439109  DT.91723542  DT.40130704  DT.91723544  DT.100008065  DT.40273750  DT.91866885 

    24/42 AceView cDNA sequences (see all 42):

    AI360630 BQ694102 BX462585 AK001419 NM_014053 BE904633 BX115707 N78572 
    BG283988 BG167060 BC048312 AU128008 BE042762 AA305281 CA407434 CB121791 
    BG116640 AF118637 AW188435 AU148769 AU124525 AU149851 AA533090 BG479760 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FLVCR1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:              -           -     -     -                       -                                 
    SP2:              -           -     -     -     -                 -                                 
    SP3:                                      -                                                         
    SP4:                                                                                                


    ECgene alternative splicing isoforms for FLVCR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FLVCR1 expression in normal human tissues (normalized intensities)      FLVCR1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FLVCR1 Expression
    About this image


    FLVCR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...

    See FLVCR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FLVCR1

    SOURCE GeneReport for Unigene cluster: Hs.7055

    UniProtKB/Swiss-Prot: FLVC1_HUMAN, Q9Y5Y0
    Tissue specificity: Found all hematopoietic tissues including peripheral blood lymphocytes. Some expression is
    found in pancreas and kidney

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FLVCR1 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mfsd7b1 , 5 major facilitator superfamily domain containing 7B1, 5 81.78(n)1
    80.99(a)1
      1 (96.28 cM)5
    2268441  NM_001081259.11  NP_001074728.11 
     1910058325 
    chicken
    (Gallus gallus)
    Aves FLVCR11 feline leukemia virus subgroup C cellular receptor more 73.65(n)
    75.05(a)
      421365  XM_419425.3  XP_419425.2 
    lizard
    (Anolis carolinensis)
    Reptilia FLVCR16
    feline leukemia virus subgroup C cellular receptor...
    79(a)
    1 ↔ 1
    1(238736349-238743299)
    zebrafish
    (Danio rerio)
    Actinopterygii flvcr11 feline leukemia virus subgroup C cellular receptor more 67.31(n)
    70.45(a)
      562595  NM_001025522.1  NP_001020693.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG13586
    --
    48(a)
    1 → many
    2R(3483240-3508216)
    worm
    (Caenorhabditis elegans)
    Secernentea C09D4.16
    Uncharacterized MFS-type transporter C09D4.1
    37(a)
    1 → many
    I(5497778-5505385)


    ENSEMBL Gene Tree for FLVCR1 (if available)
    TreeFam Gene Tree for FLVCR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FLVCR1 gene
    MFSD72  FLVCR22  DIRC22  
    1 SIMAP similar gene for FLVCR1 using alignment to 2 protein entries:     FLVC1_HUMAN (see all proteins):
    FLVCR2

    FLVCR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1160 SNPs in FLVCR1 are shown (see all 1160)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0651604
    Posterior column ataxia with retinitis pigmentosa (PCARP)4--see VAR_0651602 A T mis40--------
    VAR_0651594
    Posterior column ataxia with retinitis pigmentosa (PCARP)4--see VAR_0651592 C R mis40--------
    VAR_0651614
    Posterior column ataxia with retinitis pigmentosa (PCARP)4--see VAR_0651612 G R mis40--------
    VAR_0651584
    Posterior column ataxia with retinitis pigmentosa (PCARP)4--see VAR_0651582 N D mis40--------
    rs2676068201,2
    Cpathogenic1219826890(+) TGGTCA/GACGCC 2 N D mis10--------
    rs412966821,2
    F--183708481(+) GGCCAT/CTGCAT 1 -- us2k15Minor allele frequency- C:0.02NS 376
    rs677917381,2
    C--183715921(+) AGGGA-/TTTTT 
            
    TTTTT
    1 -- int10--------
    rs675964131,2
    C--183723581(+) AAAAAA/TAAAAG 1 -- int14Minor allele frequency- T:0.12NA WA 8
    rs108640211,2
    C,F,A,H--183724784(+) tttttC/Tctttt 1 -- int1 trp36Minor allele frequency- T:0.17NA WA 12
    rs2010612611,2
    C--183734097(+) TCTCC-/TTTTTTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for FLVCR1 (213031597 - 213072705 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FLVCR1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2722517CNV Deletion23290073
    esv1413001CNV Deletion17803354
    esv2674192CNV Deletion23128226
    dgv99n67CNV Loss20364138


    Human Gene Mutation Database (HGMD): FLVCR1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609144   
    OMIM disorders: 609033  
    UniProtKB/Swiss-Prot: FLVC1_HUMAN, Q9Y5Y0
  • Posterior column ataxia with retinitis pigmentosa (PCARP) [MIM:609033]: A neurodegenerative syndrome
    beginning in infancy with areflexia and retinitis pigmentosa. Nyctalopia (night blindness) and peripheral visual
    field loss are usually evident during late childhood or teenage years, with subsequent progressive constriction
    of the visual fields and loss of central retinal function over time. A sensory ataxia caused by degeneration of
    the posterior columns of the spinal cord results in a loss of proprioceptive sensation that is clinically evident
    in the second decade of life and gradually progresses. Scoliosis, camptodactyly, achalasia, gastrointestinal
    dysmotility, and a sensory peripheral neuropathy are variable features of the disease. Affected individuals have
    no clinical or radiological evidence of cerebral or cerebellar involvement. Note=The disease is caused by
    mutations affecting the gene represented in this entry. Defective neuronal heme transmembrane export due to
    FLVCR1 mutations may abrogate the neuroprotective effects of neuroglobin and initiate an apoptotic cascade that
    results in the selective degeneration of photoreceptors in the neurosensory retina and sensory neurons in the
    posterior spinal cord

  • 17 diseases for FLVCR1:    About MalaCards
    posterior column ataxia    posterior column ataxia with retinitis pigmentosa    sensory peripheral neuropathy    achalasia
    retinitis pigmentosa    diamond-blackfan anemia    ataxia    peripheral neuropathy
    retinitis    scoliosis    night blindness    leukemia
    blindness    neuropathy    anemia    cerebritis
    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for FLVCR1:
    Diamond-Blackfan anemia     Retinitis pigmentosa

    FLVCR1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): FLVCR1

    Export disorders for FLVCR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FLVCR1 gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with FLVCR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A putative cell surface receptor for anemia-inducing feline leukemia virus subgroup C is a member of a transporter superfamily. (PubMed id 10400745)1, 2, 3, 9 Tailor C.S.... Kabat D. (1999)
    2. Mutations in FLVCR1 cause posterior column ataxia and retinitis pigmentosa. (PubMed id 21070897)1, 2, 3 Rajadhyaksha A.M....Higgins J.J. (2010)
    3. Genomic structure and evolutionary context of the human feline leukemia virus subgroup C receptor (hFLVCR) gene: evidence for block duplications and de novo gene formation within duplicons of the hFLVCR locus. (PubMed id 11943475)1, 2, 9 Lipovich L.... Quigley J.G. (2002)
    4. Posterior column ataxia with retinitis pigmentosa in a Japanese family with a novel mutation in FLVCR1. (PubMed id 21267618)1, 2 Ishiura H....Tsuji S. (2011)
    5. Kinetics and specificity of feline leukemia virus sub group C receptor (FLVCR) export function and its dependence on hemopexin. (PubMed id 20610401)1, 2 Yang Z....Abkowitz J.L. (2010)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Identification of a human heme exporter that is essential for erythropoiesis. (PubMed id 15369674)1, 2 Quigley J.G.... Abkowitz J.L. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Cloning of the cellular receptor for feline leukemia virus subgroup C (FeLV-C), a retrovirus that induces red cell aplasia. (PubMed id 10648427)1, 3 Quigley J.G....Abkowitz J.L. (2000)
    10. Enhanced alternative splicing of the FLVCR1 gene in Diamond Blackfan anemia disrupts FLVCR1 expression and function that are critical for erythropoiesis. (PubMed id 18815190)1, 9 Rey M.A....Tailor C.S. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 28982 HGNC: 24682 AceView: FLVCR Ensembl:ENSG00000162769 euGenes: HUgn28982
    ECgene: FLVCR1 H-InvDB: FLVCR1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FLVCR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FLVCR1 gene:
    Search GeneIP for patents involving FLVCR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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