Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FLVCR1 Gene

protein-coding   GIFtS: 57
GCID: GC01P213031

Feline Leukemia Virus Subgroup C Cellular Receptor 1

(Previous names: ataxia, posterior column 1, with retinitis pigmentosa)
(Previous symbol: AXPC1)
  See FLVCR1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Feline Leukemia Virus Subgroup C Cellular Receptor 11 2     MFSD7B2
AXPC11 2 5     PCA2
FLVCR2 3     Feline Leukemia Virus Subgroup C Receptor-Related Protein 12
PCARP2 5     Feline Leukemia Virus Subgroup C Receptor3
Ataxia, Posterior Column 1, With Retinitis Pigmentosa1     hFLVCR3

External Ids:    HGNC: 246821   Entrez Gene: 289822   Ensembl: ENSG000001627697   OMIM: 6091445   UniProtKB: Q9Y5Y03   

Export aliases for FLVCR1 gene to outside databases

Previous GC identifers: GC01P211099 GC01P183708


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FLVCR1 Gene:
This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein is a
heme transporter that may play a critical role in erythropoiesis by protecting developing erythroid cells from
heme toxicity. This gene may play a role in posterior column ataxia with retinitis pigmentosa and the
hematological disorder Diamond-Blackfan syndrome. (provided by RefSeq, Jan 2011)

GeneCards Summary for FLVCR1 Gene:
FLVCR1 (feline leukemia virus subgroup C cellular receptor 1) is a protein-coding gene. Diseases associated with FLVCR1 include posterior column ataxia with retinitis pigmentosa, and posterior column ataxia. GO annotations related to this gene include heme transporter activity and transporter activity. An important paralog of this gene is MFSD7.

UniProtKB/Swiss-Prot: FLVC1_HUMAN, Q9Y5Y0
Function: Isoform 1: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and
protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export
bilirubin. Heme export depends on the presence of HPX and may be required to protect developing erythroid cells
from heme toxicity. Heme export also provides protection from heme or ferrous iron toxicities in liver and brain.
Causes susceptibility to FeLV-C in vitro. Required during erythtopoiesis to maintain intracellular free heme
balance since in proerythroblasts, heme synthesis intensifies and it's accumulation is toxic for cells
Function: Isoform 2: Heme transporter that promotes heme efflux from the mitochondrion to the cytoplasm. Essential
for erythroid differentiation

Gene Wiki entry for FLVCR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FLVCR1 gene promoter:
         NF-YA   C/EBPalpha   PPAR-gamma1   CBF-A   CBF-B   HOXA5   PPAR-gamma2   CP1A   NF-Y   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFLVCR1 promoter sequence
   Search Chromatin IP Primers for FLVCR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FLVCR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.3   Ensembl cytogenetic band:  1q32.3   HGNC cytogenetic band: 1q32.3

FLVCR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FLVCR1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P213031:  view genomic region     (about GC identifiers)

Start:
213,031,597 bp from pter      End:
213,072,705 bp from pter
Size:
41,109 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FLVC1_HUMAN, Q9Y5Y0 (See protein sequence)
Recommended Name: Feline leukemia virus subgroup C receptor-related protein 1  
Size: 555 amino acids; 59863 Da
Subunit: Interacts with HPX
Developmental stage: Down-regulated in haemopoietic progenitor cells undergoing differentiation and
hemoglobinization. Abundant in fetal liver
Secondary accessions: Q1HE16 Q86XY9 Q9NVR9
Alternative splicing: 2 isoforms:  Q9Y5Y0-1   Q9Y5Y0-2   (Has a probable mitochondrial transit peptide at positions 1-38)

Explore the universe of human proteins at neXtProt for FLVCR1: NX_Q9Y5Y0

Explore proteomics data for FLVCR1 at MOPED

Post-translational modifications: 

  • N-Glycosylated1
  • Glycosylation2 at Asn265, Asn273
  • Modification sites at PhosphoSitePlus

  • See FLVCR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_054772.1  
    ENSEMBL proteins: 
     ENSP00000355938   ENSP00000414680  
    Reactome Protein details: Q9Y5Y0

    FLVCR1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FLVCR1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for FLVCR1
    GenScript Custom Purified and Recombinant Proteins Services for FLVCR1
    Novus Biologicals FLVCR1 Proteins
    Novus Biologicals FLVCR1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FLVCR1

     
    Search eBioscience for Proteins for FLVCR1 

    FLVCR1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for FLVCR1
    OriGene Custom Antibody Services for FLVCR1
    Novus Biologicals FLVCR1 Antibodies
    Search for Antibodies for FLVCR1 at Abcam
    Cloud-Clone Corp. Antibodies for FLVCR1
    ThermoFisher Antibodies for FLVCR1
    LSBio Antibodies in human, mouse, rat for FLVCR1

    FLVCR1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FLVCR1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FLVCR1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FLVCR1
    Cloud-Clone Corp. CLIAs for FLVCR1
    Search eBioscience for ELISAs for FLVCR1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Feline leukemia virus subgroup C cellular receptor family, member 1
    SLC49 family of FLVCR-related haem transporters

    3 InterPro protein domains:
     IPR011701 MFS
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q9Y5Y0

    ProtoNet protein and cluster: Q9Y5Y0

    UniProtKB/Swiss-Prot: FLVC1_HUMAN, Q9Y5Y0
    Similarity: Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor (TC
    2.A.1.28.1) family


    Find genes that share domains with FLVCR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FLVC1_HUMAN, Q9Y5Y0
    Function: Isoform 1: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and
    protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export
    bilirubin. Heme export depends on the presence of HPX and may be required to protect developing erythroid cells
    from heme toxicity. Heme export also provides protection from heme or ferrous iron toxicities in liver and brain.
    Causes susceptibility to FeLV-C in vitro. Required during erythtopoiesis to maintain intracellular free heme
    balance since in proerythroblasts, heme synthesis intensifies and it's accumulation is toxic for cells
    Function: Isoform 2: Heme transporter that promotes heme efflux from the mitochondrion to the cytoplasm. Essential
    for erythroid differentiation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity TAS10648427
    GO:0005515protein binding IPI--
    GO:0015232heme transporter activity IMP15369674
         
    Find genes that share ontologies with FLVCR1           About GenesLikeMe


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mfsd7b):
     cardiovascular system  craniofacial  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  mortality/aging  normal 
     renal/urinary system  reproductive system  respiratory system  skeleton 

    Find genes that share phenotypes with FLVCR1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Mfsd7btm1.1Jlab for FLVCR1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FLVCR1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FLVCR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FLVCR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FLVCR1

    miRNA
    Products:
        
    miRTarBase miRNAs that target FLVCR1:
    hsa-mir-192-5p (MIRT026120)

    Block miRNA regulation of human, mouse, rat FLVCR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FLVCR1 (see all 46):
    hsa-miR-579 hsa-miR-3607-3p hsa-miR-429 hsa-miR-30d hsa-miR-30a hsa-miR-133a hsa-miR-200b hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidFLVCR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FLVCR1
    Predesigned siRNA for gene silencing in human, mouse, rat FLVCR1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FLVCR1

    Clone
    Products:
         
    OriGene clones in human, mouse for FLVCR1 (see all 8)
    OriGene ORF clones in mouse, rat for FLVCR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FLVCR1 (NM_014053)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FLVCR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLVCR1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FLVCR1
    Browse ESI BIO Cell Lines and PureStem Progenitors for FLVCR1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLVCR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FLVC1_HUMAN, Q9Y5Y0: Isoform 1: Cell membrane; Multi-pass membrane protein (By similarity)
    FLVC1_HUMAN, Q9Y5Y0: Isoform 2: Mitochondrion membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS10648427
    GO:0016021integral component of membrane ----
    GO:0031966mitochondrial membrane IEA--

    Find genes that share ontologies with FLVCR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FLVCR1 About    
    See pathways by source

    SuperPathContained pathways About
    1Insulin receptor recycling
    Iron uptake and transport0.70
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47


    Find genes that share SuperPaths with FLVCR1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for FLVCR1
        Iron uptake and transport


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FLVCR1
    Interactions:

        Search GeneGlobe Interaction Network for FLVCR1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for FLVCR1 (ENSP000003559384) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001568blood vessel development IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0006810transport TAS10648427
    GO:0006839mitochondrial transport IDA--
    GO:0006879cellular iron ion homeostasis TAS--

    Find genes that share ontologies with FLVCR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FLVCR1 (FLVC1)

    1 HMDB Compound for FLVCR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FLVCR1 gene: 
    NM_014053.3  

    Unigene Cluster for FLVCR1:

    Feline leukemia virus subgroup C cellular receptor 1
    Hs.7055  [show with all ESTs]
    Unigene Representative Sequence: NM_014053
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366971(uc001hjt.3) ENST00000419102 ENST00000579295 ENST00000474693
    ENST00000483790
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FLVCR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FLVCR1 (see all 46):
    hsa-miR-579 hsa-miR-3607-3p hsa-miR-429 hsa-miR-30d hsa-miR-30a hsa-miR-133a hsa-miR-200b hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidFLVCR1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FLVCR1
    Predesigned siRNA for gene silencing in human, mouse, rat FLVCR1
    Clone
    Products:
         
    OriGene clones in human, mouse for FLVCR1 (see all 8)
    OriGene ORF clones in mouse, rat for FLVCR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FLVCR1 (NM_014053)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FLVCR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLVCR1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FLVCR1
    OriGene qSTAR qPCR primer pairs in human, mouse for FLVCR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FLVCR1
      QuantiTect SYBR Green Assays in human, mouse, rat FLVCR1
      QuantiFast Probe-based Assays in human, mouse, rat FLVCR1

    Additional mRNA sequence: 

    AF118637.1 AK001419.1 AK090739.1 AK314481.1 BC048312.1 

    8 DOTS entries:

    DT.215823  DT.439109  DT.91723542  DT.40130704  DT.91723544  DT.100008065  DT.40273750  DT.91866885 

    Selected AceView cDNA sequences (see all 42):

    AI360630 BQ694102 BX462585 AK001419 N78572 BE904633 BG167060 AA305281 
    AU148769 BC048312 NM_014053 AU124525 BX115707 BG283988 BE042762 AU128008 
    BG116640 CA407434 AW188435 AF118637 CB121791 AU149851 AL560770 AA533090 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FLVCR1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:              -           -     -     -                       -                                 
    SP2:              -           -     -     -     -                 -                                 
    SP3:                                      -                                                         
    SP4:                                                                                                


    ECgene alternative splicing isoforms for FLVCR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FLVCR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FLVCR1 Expression
    About this image

    FLVCR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FLVCR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.7055

    UniProtKB/Swiss-Prot: FLVC1_HUMAN, Q9Y5Y0
    Tissue specificity: Found all hematopoietic tissues including peripheral blood lymphocytes. Some expression is
    found in pancreas and kidney

        Custom PCR Arrays for FLVCR1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FLVCR1
    OriGene qSTAR qPCR primer pairs in human, mouse for FLVCR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FLVCR1
    QuantiTect SYBR Green Assays in human, mouse, rat FLVCR1
    QuantiFast Probe-based Assays in human, mouse, rat FLVCR1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLVCR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for FLVCR1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mfsd7b1 , 5 major facilitator superfamily domain containing 7B1, 5 81.72(n)1
    80.99(a)1
      1 (96.28 cM)5
    2268441  NM_001081259.11  NP_001074728.11 
     1910058325 
    chicken
    (Gallus gallus)
    Aves FLVCR11 feline leukemia virus subgroup C cellular receptor more 73.58(n)
    74.9(a)
      421365  XM_419425.4  XP_419425.2 
    lizard
    (Anolis carolinensis)
    Reptilia FLVCR16
    feline leukemia virus subgroup C cellular receptor...
    79(a)
    1 ↔ 1
    1(238736349-238743299)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia flvcr11 feline leukemia virus subgroup C cellular receptor more 69.99(n)
    75(a)
      100492275  XM_002934686.2  XP_002934732.2 
    zebrafish
    (Danio rerio)
    Actinopterygii flvcr11 feline leukemia virus subgroup C cellular receptor more 66.6(n)
    69.56(a)
      562595  NM_001025522.1  NP_001020693.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG13586
    --
    49(a)
    1 → many
    2R(3483240-3508216)
    worm
    (Caenorhabditis elegans)
    Secernentea C09D4.16
    Protein C09D4.1, isoform a
    38(a)
    1 → many
    I(5497778-5505385) WBGene00015632


    ENSEMBL Gene Tree for FLVCR1 (if available)
    TreeFam Gene Tree for FLVCR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FLVCR1 gene
    MFSD72  FLVCR22  DIRC22  
    1 SIMAP similar gene for FLVCR1 using alignment to 2 protein entries:     FLVC1_HUMAN (see all proteins):
    FLVCR2

    Find genes that share paralogs with FLVCR1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FLVCR1 (see all 1160)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0651604
    Posterior column ataxia with retinitis pigmentosa (PCARP)4--see VAR_0651602 A T mis40--------
    VAR_0651594
    Posterior column ataxia with retinitis pigmentosa (PCARP)4--see VAR_0651592 C R mis40--------
    VAR_0651614
    Posterior column ataxia with retinitis pigmentosa (PCARP)4--see VAR_0651612 G R mis40--------
    VAR_0651584
    Posterior column ataxia with retinitis pigmentosa (PCARP)4--see VAR_0651582 N D mis40--------
    rs2676068201,2
    Cpathogenic1219826890(+) TGGTCA/GACGCC 2 N D mis10--------
    rs412966821,2
    F--183708481(+) GGCCAT/CTGCAT 1 -- us2k15Minor allele frequency- C:0.02NS 376
    rs677917381,2
    C--183715921(+) AGGGA-/TTTTT 
            
    TTTTT
    1 -- int10--------
    rs675964131,2
    C--183723581(+) AAAAAA/TAAAAG 1 -- int14Minor allele frequency- T:0.12NA WA 8
    rs108640211,2
    C,F,A,H--183724784(+) tttttC/Tctttt 1 -- int1 trp36Minor allele frequency- T:0.17NA WA 12
    rs2010612611,2
    C--183734097(+) TCTCC-/TTTTTTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for FLVCR1 (213031597 - 213072705 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FLVCR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2722517CNV Deletion23290073
    esv1413001CNV Deletion17803354
    esv2674192CNV Deletion23128226
    dgv99n67CNV Loss20364138

    Human Gene Mutation Database (HGMD): FLVCR1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FLVCR1
    DNA2.0 Custom Variant and Variant Library Synthesis for FLVCR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609144   
    OMIM disorders: 609033  
    UniProtKB/Swiss-Prot: FLVC1_HUMAN, Q9Y5Y0
  • Posterior column ataxia with retinitis pigmentosa (PCARP) [MIM:609033]: A neurodegenerative syndrome
    beginning in infancy with areflexia and retinitis pigmentosa. Nyctalopia (night blindness) and peripheral visual
    field loss are usually evident during late childhood or teenage years, with subsequent progressive constriction
    of the visual fields and loss of central retinal function over time. A sensory ataxia caused by degeneration of
    the posterior columns of the spinal cord results in a loss of proprioceptive sensation that is clinically evident
    in the second decade of life and gradually progresses. Scoliosis, camptodactyly, achalasia, gastrointestinal
    dysmotility, and a sensory peripheral neuropathy are variable features of the disease. Affected individuals have
    no clinical or radiological evidence of cerebral or cerebellar involvement. Note=The disease is caused by
    mutations affecting the gene represented in this entry. Defective neuronal heme transmembrane export due to
    FLVCR1 mutations may abrogate the neuroprotective effects of neuroglobin and initiate an apoptotic cascade that
    results in the selective degeneration of photoreceptors in the neurosensory retina and sensory neurons in the
    posterior spinal cord

  • 5 diseases for FLVCR1:    
    About MalaCards
    posterior column ataxia with retinitis pigmentosa    posterior column ataxia    retinitis    retinitis pigmentosa
    ataxia

    2 diseases from the University of Copenhagen DISEASES database for FLVCR1:
    Diamond-Blackfan anemia     Retinitis pigmentosa

    Find genes that share disorders with FLVCR1           About GenesLikeMe

    Genetic Association Database (GAD): FLVCR1

    Export disorders for FLVCR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FLVCR1 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with FLVCR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A putative cell surface receptor for anemia-inducing feline leukemia virus subgroup C is a member of a transporter superfamily. (PubMed id 10400745)1, 2, 3, 9 Tailor C.S.... Kabat D. (J. Virol. 1999)
    2. Mutations in FLVCR1 cause posterior column ataxia and retinitis pigmentosa. (PubMed id 21070897)1, 2, 3 Rajadhyaksha A.M.... Higgins J.J. (Am. J. Hum. Genet. 2010)
    3. Genomic structure and evolutionary context of the human feline leukemia virus subgroup C receptor (hFLVCR) gene: evidence for block duplications and de novo gene formation within duplicons of the hFLVCR locus. (PubMed id 11943475)1, 2, 9 Lipovich L.... Quigley J.G. (Gene 2002)
    4. The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation. (PubMed id 23187127)1, 2 Chiabrando D....Tolosano E. (J. Clin. Invest. 2012)
    5. Posterior column ataxia with retinitis pigmentosa in a Japanese family with a novel mutation in FLVCR1. (PubMed id 21267618)1, 2 Ishiura H.... Tsuji S. (Neurogenetics 2011)
    6. Kinetics and specificity of feline leukemia virus subgroup C receptor (FLVCR) export function and its dependence on hemopexin. (PubMed id 20610401)1, 2 Yang Z.... Abkowitz J.L. (J. Biol. Chem. 2010)
    7. Comprehensive mapping of receptor-functioning domains in feline leukemia virus subgroup C receptor FLVCR1. (PubMed id 16439531)1, 2 Brown J.K....Tailor C.S. (J. Virol. 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Identification of a human heme exporter that is essential for erythropoiesis. (PubMed id 15369674)1, 2 Quigley J.G.... Abkowitz J.L. (Cell 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 28982 HGNC: 24682 AceView: FLVCR Ensembl:ENSG00000162769 euGenes: HUgn28982
    ECgene: FLVCR1 H-InvDB: FLVCR1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FLVCR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FLVCR1 gene:
    Search GeneIP for patents involving FLVCR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for FLVCR1   OriGene RNAi products in human, mouse, rat for FLVCR1  
     OriGene qPCR primer pairs and template standards for FLVCR1   OriGene Protein Over-expression Lysate for FLVCR1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FLVCR1  
     OriGene qSTAR qPCR primer pairs in human, mouse for FLVCR1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FLVCR1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FLVCR1   OriGene Custom Protein Services for FLVCR1  

     
     
     Block miRNA regulation of human, mouse, rat FLVCR1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FLVCR1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FLVCR1 Predesigned siRNA for gene silencing in human, mouse, rat FLVCR1
     QuantiFast Probe-based Assays in human, mouse, rat FLVCR1 QuantiTect SYBR Green Assays in human, mouse, rat FLVCR1
     Custom PCR Arrays for FLVCR1 Search Chromatin IP Primers for FLVCR1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FLVCR1  Search GeneGlobe Interaction Network for FLVCR1
     Regulatory tfbs in FLVCR1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for FLVCR1 GenScript cDNA clones with any tag delivered in your preferred vector for FLVCR1
     GenScript Custom Assay Services for FLVCR1 GenScript Custom overexpressing Cell Line Services for FLVCR1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FLVCR1 (FLVC1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FLVCR1 antibodies
     FLVCR1 proteins
     FLVCR1 lysates
     Search for Antibodies for FLVCR1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for FLVCR1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for FLVCR1
     Antibodies for FLVCR1
     ELISAs for FLVCR1
     CLIAs for FLVCR1



     Browse ESI BIO Cell Lines and PureStem Progenitors for FLVCR1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLVCR1
     SwitchGear 3'UTR luciferase reporter plasmids for FLVCR1
     SwitchGear Promoter luciferase reporter plasmids for FLVCR1
     ThermoFisher Antibodies for FLVCR1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLVCR1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FLVCR1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FLVCR1
     LSBio Antibodies in human, mouse, rat for FLVCR1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for FLVCR1
      Search eBioscience for proteins for FLVCR1
      Search eBioscience for elisas for FLVCR1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FLVCR1 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4