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Aliases & Descriptions for FLVCR1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLVCR 1, 2, 3 | | OTTHUMP00000035011 2 | | hFLVCR 3 |
| | | Descriptions |
|---|
| Feline leukemia virus subgroup C receptor 3 | | feline leukemia virus subgroup C cellular receptor 1 2 |
|
| | Search outside databases for aliases for FLVCR1 gene |
Summaries for FLVCR1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: FLVC1_HUMAN, Q9Y5Y0Function: Exports cytoplasmic heme. May be required to protect developing erythroid cells from heme toxicity. Causes susceptibility to FeLV-C in vitroGene Wiki entry for FLVCR1 |
Genomic Location for FLVCR1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q32.3 Ensembl cytogenetic band: 1q32.3 HGNC cytogenetic band: 1q32.3FLVCR1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P211099:
(about GC identifiers)
Start:
|
211,098,220 bp from pter |
End:
|
211,135,379 bp from pter |
Size:
|
37,160 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000001.9 NT_021877.18
| Proteins for FLVCR1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: FLVC1_HUMAN, Q9Y5Y0 (See
protein sequence)Recommended Name: Feline leukemia virus subgroup C receptor-related protein 1 Size: 555 amino acids; 59863 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity)
Developmental stage: Down-regulated in haemopoietic progenitor cells undergoing differentiation and hemoglobinization. Abundant in fetal liver
Secondary accessions: Q86XY9 Q9NVR9Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_054772.1
ENSEMBL proteins: ENSP00000355938
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for FLVCR1: Assays for FLVCR1: | Protein
Domains/ Families for FLVCR1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9Y5Y0
ProtoNet protein and cluster: Q9Y5Y0 UniProtKB/Swiss-Prot: FLVC1_HUMAN, Q9Y5Y0Similarity: Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family | Gene Function for FLVCR1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014053
Applied Biosystems Silencer® siRNAs for FLVCR1
Sigma-Aldrich siRNA and siRNA Panels for FLVCR1  Sigma-Aldrich shRNA for FLVCR1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014053                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014053                                  untagged cDNA clones in CMV expression vector (see all 2): NM_014053 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014053
UniProtKB/Swiss-Prot: FLVC1_HUMAN, Q9Y5Y0Function: Exports cytoplasmic heme. May be required to protect developing erythroid cells from heme toxicity. Causes susceptibility to FeLV-C in vitro11 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Mfsd7b):
2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for FLVCR1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Interacting protein for FLVCR1 (ENSP000003559383) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for FLVCR1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for FLVCR1
|
Transcripts for FLVCR1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014053
Sigma-Aldrich siRNA and siRNA Panels for FLVCR1  Sigma-Aldrich shRNA for FLVCR1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_014053 REFSEQ mRNAs for FLVCR1 gene: NM_014053.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_014053               OriGene GFP tagged cDNA clone in CMV expression vector: NM_014053                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014053                                  untagged cDNA clones in CMV expression vector (see all 2): NM_014053  Additional cDNA sequence: AF118637.1 AK001419.1 AK314481.1 BC048312.1 6 DOTS entries: DT.439109 DT.91723542 DT.40130704 DT.91723544 DT.100008065 DT.40273750 24/42 AceView cDNA sequences (see all 42
):BX462585 AK001419 BQ694102 AI360630 BC048312 AU148769 N78572 AU128008 AU124525 AA305281 AW188435 BG283988 BX115707 AF118637 CB121791 BG167060 NM_014053 BE904633 BE042762 BG116640 CA407434 AL582174 BQ957760 BG479760 Unigene Cluster for FLVCR1: Feline leukemia virus subgroup C cellular receptor 1 Hs.7055 [show with all ESTs]Unigene Representative Sequence: NM_014053
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for FLVCR1
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | |
| SP1: | |   | |   | - |   | |   | - |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | |   | - |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for FLVCR1
1 Ensembl transcript including schematic representation: ENST00000366971
|
Expression for FLVCR1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| FLVCR1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for FLVCR1
1 / 2 3 probe-sets matching FLVCR1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ACTGGTTACC
SOURCE GeneReport for Unigene cluster: Hs.7055 UniProtKB/Swiss-Prot: FLVC1_HUMAN, Q9Y5Y0Tissue specificity: Found all hematopoietic tissues including peripheral blood lymphocytes. Some expression is found in pancreas and kidney |
Orthologs for FLVCR1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for FLVCR1 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for FLVCR1
ENSEMBL Gene Tree for FLVCR1 | Paralogs for FLVCR1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for FLVCR1 gene
- MFSD72 FLVCR22 DIRC22
|
SNPs/Variants for FLVCR1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for FLVCR1 (up to first 250kb)
|
Disorders & Mutations for FLVCR1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 609144
|
Medical News for FLVCR1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for FLVCR1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/13 PubMed articles for FLVCR1 gene (see all 13
):- A putative cell surface receptor for anemia-inducing feline leukemia virus subgroup C is a member of a transporter superfamily. (PubMed id 10400745)1, 2, 3, 4 Tailor C.S.... Kabat D. (1999)
- Genomic structure and evolutionary context of the human feline leukemia virus subgroup C receptor (hFLVCR) gene: evidence for block duplications and de novo gene formation within duplicons of the hFLVCR locus. (PubMed id 11943475)1, 3, 4 Lipovich L.... Quigley J.G. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Identification of a human heme exporter that is essential for erythropoiesis. (PubMed id 15369674)3, 4 Quigley J.G.... Abkowitz J.L. (2004)
- Cloning of the cellular receptor for feline leukemia virus subgroup C (FeLV-C), a retrovirus that induces red cell aplasia. (PubMed id 10648427)2, 3 Quigley J.G....Abkowitz J.L. (2000)
- Enhanced alternative splicing of the FLVCR1 gene in Diamond Blackfan anemia disrupts FLVCR1 expression and function that are critical for erythropoiesis. (PubMed id 18815190)1, 3 Rey M.A....Tailor C.S. (2008)
- Comprehensive mapping of receptor-functioning domains in feline leukemia virus subgroup C receptor FLVCR1. (PubMed id 16439531)3 Brown J.K....Tailor C.S. (2006)
- Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. (PubMed id 16368877)3 Choy K.W....Pang C.P. (2006)
- Investigation of a putative role for FLVCR, a cytoplasmic heme exporter, in Diamond-Blackfan anemia. (PubMed id 15996880)3 Quigley J.G....Abkowitz J.L. (2005)
|
Search for FLVCR1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing FLVCR1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing FLVCR1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FLVCR1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for FLVCR1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for FLVCR1:

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Incremental update: 13 Oct 2009
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