Aliases for FLT4 Gene
Aliases for FLT4 Gene
External Ids for FLT4 Gene
- HGNC: 3767
- Entrez Gene: 2324
- Ensembl: ENSG00000037280
- OMIM: 136352
- UniProtKB: P35916
Previous GeneCards Identifiers for FLT4 Gene
- GC05M180162
- GC05M181012
- GC05M180139
- GC05M180132
- GC05M179962
- GC05M180028
- GC05M174752
Summaries for FLT4 Gene
-
This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008]
GeneCards Summary for FLT4 Gene
FLT4 (Fms Related Tyrosine Kinase 4) is a Protein Coding gene. Diseases associated with FLT4 include Lymphedema, Hereditary, Ia and Hemangioma, Capillary Infantile. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is KDR.
UniProtKB/Swiss-Prot for FLT4 Gene
-
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at Thr-183 and Tyr-185, and of AKT1 at Ser-473.
-
Vascular endothelial growth factor is a signaling protein involved in the regulation of angiogenesis and vasculogenesis. VEGF binds to and activates a receptor tyrosine kinase, VEGFR, through transphosphorylation. Three VEGFR isoforms have been identified in humans.
Additional gene information for FLT4 Gene
- Monarch Initiative
- Search for FLT4 at DataMed
- Search for FLT4 at HumanCyc
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLT4 Gene
Genomics for FLT4 Gene
GeneHancer (GH) Regulatory Elements for FLT4 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH05I180649 | Promoter | 1.5 | EPDnew Ensembl | 550.8 | +0.8 | 770 | 0.6 | CTCF MAZ ZBTB6 L3MBTL2 ZNF189 ZNF398 ZEB2 ZIC2 ZNF335 CTBP2 | FLT4 PIR50427 GC05M180610 | |
GH05I180618 | Promoter | 1 | Ensembl | 11.9 | +31.2 | 31170 | 0.6 | CTCF MXI1 ZIC2 ZNF335 FOXM1 E2F1 ZFHX2 GLIS2 POLR2A ZBTB48 | FLT4 GC05M180610 PIR50427 | |
GH05I180560 | Enhancer | 0.9 | ENCODE | 12 | +87.8 | 87782 | 3.6 | HDGF HDAC1 PKNOX1 ARNT TCF12 GATA2 ZNF143 SIRT6 ATF7 RUNX3 | SCGB3A1 FLT4 CNOT6 ENSG00000248367 GC05P180580 LOC100329129 | |
GH05I180688 | Enhancer | 0.9 | FANTOM5 Ensembl ENCODE | 11.7 | -39.5 | -39482 | 3.3 | ZNF335 RNF2 BMI1 ZFX EZH2 EGR2 | GC05P181026 GC05P181038 PIR40400 PIR57207 PIR46573 FLT4 OR2Y1 MGAT1 GC05P181030 PIR39363 | |
GH05I180623 | Enhancer | 0.5 | Ensembl | 12.4 | +26.8 | 26770 | 0.6 | ATF1 GABPB1 CREB1 NR2F2 SPI1 | FLT4 GC05M180610 PIR50427 |
Regulatory Element Products
Genomic Locations for FLT4 Gene
- chr5:180,601,506-180,650,271
- (GRCh38/hg38)
- Size:
- 48,766 bases
- Orientation:
- Minus strand
- chr5:180,028,506-180,076,624
- (GRCh37/hg19)
Genomic View for FLT4 Gene
- Cytogenetic band:
-
- 5q35.3 by Ensembl
- 5q35.3 by Entrez Gene
- 5q35.3 by HGNC


RefSeq DNA sequence for FLT4 Gene
Proteins for FLT4 Gene
-
Protein details for FLT4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35916-VGFR3_HUMAN
- Recommended name:
- Vascular endothelial growth factor receptor 3
- Protein Accession:
- P35916
- A8K6L4
- B5A926
- Q16067
- Q86W07
- Q86W08
Protein attributes for FLT4 Gene
- Size:
- 1363 amino acids
- Molecular mass:
- 152757 Da
- Quaternary structure:
-
- Interacts with VEGFC and VEGFD. Monomer in the absence of bound VEGFC or VEGFD. Homodimer in the presence of bound VEGFC or VEGFD. Can also form a heterodimer with KDR. Interacts with PTPN14; the interaction is enhanced by stimulation with VEGFC. Interacts with CRK, GRB2, PTK2/FAK1, SHC1, PIK3R1 and PTPN11/SHP-2. Identified in a complex with SRC and ITGB1.
- SequenceCaution:
-
- Sequence=CAA48290.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for FLT4 Gene
Selected DME Specific Peptides for FLT4 Gene
- P35916:
-
- GTRMRAP
- KMLKEGAT
- QDAVNPIES
- QTHTELSSILT
- QVARGME
- GMEFLASRKCIHRDLAARNILLS
- RLPLKWMAPE
- RDLAARN
- CRGQHPLEW
- YLCSVCNAKGCVNSSASV
- YLSIIMDP
- VAVKMLK
- HLNVVNLLGACTK
- HSLAARYYN
- ALMSELK
- WEIFSLG
- KTGYLSI
- KICDFGLARD
- DSGMVLASEE
- KWMAPESIF
- FSLGASPYP
- WVPCLVSIP
- KHCHKKY
- SRKCIHRDLAARNILLSE
- ANVSAMYKC
- LSIQRVREEDAG
- NKTVSKL
- GPLMVIVE
- SSPSIYSR
- LDCKNVH
- YSMTPPTL
- CKYGNLSN
- DERLIYFYVTTIP
- PDYVRKG
- DFGLARDI
- VNVPPQI
- CYSFQVA
Post-translational modifications for FLT4 Gene
- Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation in response to H(2)O(2) is mediated by a process that requires SRC and PRKCD activity. Phosphorylation at Tyr-1068 is required for autophosphorylation at additional tyrosine residues. Phosphorylation at Tyr-1063 and Tyr-1337 is important for interaction with CRK and subsequent activation of MAPK8. Phosphorylation at Tyr-1230, Tyr-1231 and Tyr-1337 is important for interaction with GRB2 and subsequent activation of the AKT1 and MAPK1/ERK2 and/or MAPK3/ERK1 signaling pathways. In response to endothelial cell adhesion onto collagen, can also be phosphorylated in the absence of FLT4 kinase activity by SRC at Tyr-830, Tyr-833, Tyr-853, Tyr-1063, Tyr-1333, and Tyr-1337.
- Ubiquitination at Lys1253
- Glycosylation at Asn33, Asn104, posLast=166166, Asn251, Asn299, Asn411, Asn515, Asn527, Asn594, posLast=683683, posLast=690690, and Asn758
Other Protein References for FLT4 Gene
Antibody Products
- R&D Systems Antibodies for FLT4 (VEGF R3/Flt-4)
- Cell Signaling Technology (CST) Antibodies for FLT4 (VEGFR3)
- Novus Biologicals Antibodies for FLT4
-
Abcam antibodies for FLT4
-
Cloud-Clone Corp. Antibodies for FLT4
- Invitrogen Antibodies for FLT4
- GeneTex FLT4 antibody for FLT4
-
Santa Cruz Biotechnology (SCBT) Antibodies for FLT4
- Sino Biological Antibodies for FLT4
Protein Products
- R&D Systems Proteins and Enzymes for FLT4 (VEGF R3/Flt-4)
-
OriGene Purified Proteins for FLT4
- Search Origene for MassSpec and Protein Over-expression Lysates for FLT4
- Origene Custom Protein Services for FLT4
- Novus Biologicals lysates for FLT4
- Sino Biological Cell Lysates for FLT4
- Sino Biological Recombinant Proteins for FLT4
- ProSpec Recombinant Proteins for FLT4
-
Cloud-Clone Corp. Proteins for FLT4
- Search GeneTex for Proteins for FLT4
-
ProSci Proteins for FLT4
-
Abcam proteins for FLT4
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays, Luminex Assays, ELISAs, and other biochemical assays for FLT4 (VEGF R3/Flt-4)
-
Cloud-Clone Corp. Assay Kits for FLT4
- antibodies-online: Search results for 48 available VGFR3 Elisa Kits ranked by validation data
- Compare Top VGFR3 Elisa Kits
-
Recommended
- 2 Cow (Bovine) ELISA Kits
- 22 Human ELISA Kits
- 1 Monkey ELISA Kit
- 8 Mouse (Murine) ELISA Kits
- 1 Pig (Porcine) ELISA Kit
- 13 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- 2 Cow (Bovine) ELISA Kits
- 22 Human ELISA Kits
- 1 Monkey ELISA Kit
- 8 Mouse (Murine) ELISA Kits
- 1 Pig (Porcine) ELISA Kit
- 13 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
-
Abcam assays for FLT4
- Sino Biological Assays for FLT4
Domains & Families for FLT4 Gene
Gene Families for FLT4 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for FLT4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FLT4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P35916UniProtKB/Swiss-Prot:
VGFR3_HUMAN :- The first and second Ig-like C2-type (immunoglobulin-like) domains are sufficient for VEGFC binding (PubMed:23878260). The fourth and fifth Ig-like C2-type domains are sufficient for homodimerization (PubMed:23878260). The fifth and seventh Ig-like C2-type domains are required for autophosphorylation and further activation (PubMed:23878260).
- Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
- Domain:
-
- The first and second Ig-like C2-type (immunoglobulin-like) domains are sufficient for VEGFC binding (PubMed:23878260). The fourth and fifth Ig-like C2-type domains are sufficient for homodimerization (PubMed:23878260). The fifth and seventh Ig-like C2-type domains are required for autophosphorylation and further activation (PubMed:23878260).
- Family:
-
- Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Function for FLT4 Gene
Molecular function for FLT4 Gene
- GENATLAS Biochemistry:
- fms-related receptor t tyrosine kinase 4,expressed on the surface on endothelial cells
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Present in an inactive conformation in the absence of bound ligand. Binding of VEGFC or VEGFD leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by MAZ51.
- UniProtKB/Swiss-Prot Function:
- Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at Thr-183 and Tyr-185, and of AKT1 at Ser-473.
Enzyme Numbers (IUBMB) for FLT4 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004713 | protein tyrosine kinase activity | IEA | -- |
GO:0004714 | transmembrane receptor protein tyrosine kinase activity | IEA,IMP | 7898938 |
GO:0005021 | vascular endothelial growth factor-activated receptor activity | IEA,IMP | 11532940 |
GO:0005515 | protein binding | IPI | 16530705 |
Phenotypes for FLT4 Gene
- MGI mutant phenotypes for FLT4:
-
inferred from 9 alleles
- normal phenotype
- homeostasis/metabolism phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- growth/size/body region phenotype
- digestive/alimentary phenotype
- reproductive system phenotype
- integument phenotype
- embryo phenotype
- liver/biliary system phenotype
- adipose tissue phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for FLT4:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability in esophageal squamous lineage
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Increased transferrin (TF) endocytosis
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased viability after Maraba virus infection
- Decreased viability
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased substrate adherent cell growth
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased mitotic index
- Increased Sindbis virus (SINV) infection
- Increased cilium length after serum starvation
- Increased simian virus 40 (SV40) infection
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FLT4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FLT4 gene
- Search ViGene Biosciences for FLT4
CRISPR Products
-
OriGene CRISPR knockouts for FLT4
- genomics-online: gRNA clones - Search results for 105 available VGFR3 gene related products
- Overview of 105 available VGFR3 gene related products
- Applied Biological Materials CRISPR for FLT4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FLT4
- GenScript: Design CRISPR guide RNA sequences for FLT4
miRNA for FLT4 Gene
- miRTarBase miRNAs that target FLT4
miRNA Products
- Search ViGene Biosciences for FLT4
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for FLT4
- Browse OriGene Inhibitory RNA Products For FLT4
- genomics-online: shRNA clones - Search results for 105 available FLT4 gene related products
- Overview of 105 available FLT4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for FLT4 gene
Clone Products
-
OriGene ORF clones in human for FLT4
- RG214285
- RC600028
- RC214285L2
- RC214285L1
- RC214285
- RG214232
- RC600029
- RC402608
- RC402607
- RC402606
- RC402605
- RC402604
- RC402603
- RC402602
- RC402601
- RC402600
- RC402599
- RC402598
- RC402597
- RC402596
- RC402595
- RC402594
- RC402593
- RC402592
- RC402591
- RC402590
- RC402589
- RC402588
- RC402587
- RC402586
- RC402585
- RC402584
- RC402583
- RC402582
- RC402581
- RC402580
- RC402579
- RC402578
- RC402577
- RC402576
- RC214232L2
- RC214232L1
- RC214232
- RC214285L2V
- RC214285L1V
- RC214232L2V
- RC214232L1V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FLT4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for FLT4
- Applied Biological Materials Clones for FLT4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for FLT4 (VEGF R3/Flt-4)
Cell Line Products
-
Horizon Cell Lines for FLT4
-
ViGene Biosciences adenoviral particle packaged cDNA for FLT4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FLT4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FLT4 gene
No data available for Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for FLT4 Gene
Localization for FLT4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FLT4 Gene
- Cell membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Note=Ligand-mediated autophosphorylation leads to rapid internalization. {ECO:0000269 PubMed:20445537}.
- Isoform 1: Cell membrane; Single-pass type I membrane protein. Note=Ligand-mediated autophosphorylation leads to rapid internalization.
- Isoform 2: Cell membrane; Single-pass type I membrane protein.
- Isoform 3: Secreted. Cytoplasm.
- Nuclear speckles (4)
- Plasma membrane (4)
- Cell Junctions (3)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
Pathways & Interactions for FLT4 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Apoptotic Pathways in Synovial Fibroblasts |
.74
|
.66
.65
.61
.60
|
2 | GPCR Pathway |
.73
.62
|
.55
|
3 | ERK Signaling |
.61
.58
|
.49
|
4 | Nanog in Mammalian ESC Pluripotency |
.61
|
.48
|
5 | CREB Pathway |
.68
.68
|
Pathways by source for FLT4 Gene
2 Cell Signaling Technology pathways for FLT4 Gene
2 BioSystems pathways for FLT4 Gene
4 Reactome pathways for FLT4 Gene
3 PharmGKB pathways for FLT4 Gene
8 KEGG pathways for FLT4 Gene
1 GeneGo (Thomson Reuters) pathway for FLT4 Gene
3 R&D Systems pathways for FLT4 Gene
4 Tocris pathways for FLT4 Gene
Interacting Proteins for FLT4 Gene
SIGNOR curated interactions for FLT4 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001525 | angiogenesis | IEA | -- |
GO:0001934 | positive regulation of protein phosphorylation | IMP | 11532940 |
GO:0001938 | positive regulation of endothelial cell proliferation | IMP | 11532940 |
GO:0001944 | vasculature development | ISS | -- |
GO:0001945 | lymph vessel development | ISS | -- |
Drugs & Compounds for FLT4 Gene
(85) Drugs for FLT4 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Sunitinib | Approved, Investigational | Pharma | Target, inhibitor | VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor, RTK inhibitor, Potent VEGFR, PDGFRbeta and KIT inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 518 | |
Sorafenib | Approved, Investigational | Pharma | Target, antagonist, inhibitors, inhibitor | Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 717 | |
Pazopanib | Approved | Pharma | Target, inhibitor | VEFGR, c-Kit, and PDGFR inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 0 | |
regorafenib | Approved | Pharma | Target, inhibitor | Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 0 | |
Axitinib | Approved, Investigational | Pharma | Target, inhibitor, Inhibition | Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 116 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Full agonist, Agonist | 58-64-0 |
|
||
XL 184 |
|
849217-68-1 |
|
|
(4) Tocris Compounds for FLT4 Gene
Compound | Action | Cas Number |
---|---|---|
SU 4312 | Potent inhibitor of VEGFR tyrosine kinase | 5812-07-7 |
SU 5416 | VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3 | 204005-46-9 |
Sunitinib malate | Potent VEGFR, PDGFRbeta and KIT inhibitor | 341031-54-7 |
XL 184 | Potent VEGFR inhibitor; also inhibits other RTKs | 849217-68-1 |
(30) ApexBio Compounds for FLT4 Gene
Compound | Action | Cas Number |
---|---|---|
(E)-FeCP-oxindole | 884338-18-5 | |
(Z)-FeCP-oxindole | 1137967-28-2 | |
BIBF 1120 | VEGFR/PDGF/FGFR inhibitor | 656247-17-5 |
Cabozantinib (XL184, BMS-907351) | VEGFR2/Met/Ret/Kit/FLT//AXL inhibitor | 849217-68-1 |
Cediranib (AZD217) | VEGFR inhibitor receptor,highly potent | 288383-20-0 |
DMH4 | 515880-75-8 | |
Dovitinib (TKI258) Lactate | Oral tyrosine kinase inhibitor (TKI) against FGFR1–3, VEGFR1–3, and platelet-derived growth factor receptor (PDGFR) | 915769-50-5 |
Dovitinib (TKI-258, CHIR-258) | Multitargeted RTK inhibitor | 405169-16-6 |
Dovitinib Dilactic acid | 852433-84-2 | |
Foretinib (GSK1363089) | VEGF and HGF receptor inhibitor | 849217-64-7 |
Fruquintinib(HMPL-013) | Potent and selective inhibitor of VEGFR 1, 2, 3 | 1194506-26-7 |
Ki8751 | VEGFR-2 inhibitor,potent and selective | 228559-41-9 |
KRN 633 | VEGFR inhibitor,ATP-competitive | 286370-15-8 |
Lenvatinib (E7080) | VEGFR inhibitor | 417716-92-8 |
Linifanib (ABT-869) | VEGFR/PDGFR inhibitor | 796967-16-3 |
MGCD-265 | Met/Flt/Flk/Ron/Tie-2 inhibitor | 875337-44-3 |
Motesanib Diphosphate (AMG-706) | VEGFR/ PDGFR/c-Kit/Ret inhibitor | 857876-30-3 |
Pazopanib (GW-786034) | VEGFR/PDGFR/FGFR inhibitor | 635702-64-6 |
Pazopanib Hydrochloride | VEGFR/PDGFR/FGFR/c-Kit/ c-Fms inhibitor | 635702-64-6 |
PD 173074 | FGFR inhibitor | 219580-11-7 |
SAR131675 | VEGFR3 inhibitor,selective and ATP-competitve | 1433953-83-3 |
SKLB610 | Potent VEGFR inhibitor | 1125780-41-7 |
SU 4312 | 5812-07-7 | |
Sunitinib | RTK inhibitor | 557795-19-4 |
Sunitinib malate | VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor | 341031-54-7 |
Telatinib (BAY 57-9352) | VEGFR-2/-3,PDGFR-β and c-Kit inhibitor | 332012-40-5 |
Tivozanib (AV-951) | VEGFR inhibitor,potent and selective | 475108-18-0 |
Vatalanib | VEGFR-1/-2 inhibitor,cell-permeable | 212141-54-3 |
Vatalanib (PTK787) 2HCl | Tyrosine kinase receptor inhibitor | 212141-51-0 |
ZM 306416 | VEGFR (Flt and KDR) inhibitor | 690206-97-4 |
Transcripts for FLT4 Gene
mRNA/cDNA for FLT4 Gene
- (11) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (96) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FLT4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FLT4
- genomics-online: gRNA clones - Search results for 105 available VGFR3 gene related products
- Overview of 105 available VGFR3 gene related products
- Applied Biological Materials CRISPR for FLT4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FLT4
- GenScript: Design CRISPR guide RNA sequences for FLT4
miRNA Products
- Search ViGene Biosciences for FLT4
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for FLT4
- Browse OriGene Inhibitory RNA Products For FLT4
- genomics-online: shRNA clones - Search results for 105 available FLT4 gene related products
- Overview of 105 available FLT4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for FLT4 gene
Clone Products
-
OriGene ORF clones in human for FLT4
- RG214285
- RC600028
- RC214285L2
- RC214285L1
- RC214285
- RG214232
- RC600029
- RC402608
- RC402607
- RC402606
- RC402605
- RC402604
- RC402603
- RC402602
- RC402601
- RC402600
- RC402599
- RC402598
- RC402597
- RC402596
- RC402595
- RC402594
- RC402593
- RC402592
- RC402591
- RC402590
- RC402589
- RC402588
- RC402587
- RC402586
- RC402585
- RC402584
- RC402583
- RC402582
- RC402581
- RC402580
- RC402579
- RC402578
- RC402577
- RC402576
- RC214232L2
- RC214232L1
- RC214232
- RC214285L2V
- RC214285L1V
- RC214232L2V
- RC214232L1V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FLT4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for FLT4
- Applied Biological Materials Clones for FLT4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for FLT4 (VEGF R3/Flt-4)
Expression for FLT4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Endothelium (Cardiovascular System)
- Lymphatic Endothelial Cells Lymphatic Vessels
- Venous Endothelial Cells Cardinal Veins
- Endothelial Tip Cells Arteries
- Endothelial-like cells(James D et. al. 2010)
- Skeletal Muscle (Muscoskeletal System)
-
Lymph (Hematopoietic System)
- Lymphatic Endothelial Cells Lymphatic Vessels
-
Heart (Cardiovascular System)
- Venous Endothelial Cells Cardinal Veins
-
Dermis (Integumentary System)
- Dermal Fibroblasts Dorsal Dermis
-
Fibroblasts
- Dermal Fibroblasts Dorsal Dermis
-
Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for FLT4 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FLT4 Gene
NURSA nuclear receptor signaling pathways regulating expression of FLT4 Gene:
FLT4SOURCE GeneReport for Unigene cluster for FLT4 Gene:
Hs.646917mRNA Expression by UniProt/SwissProt for FLT4 Gene:
P35916-VGFR3_HUMANEvidence on tissue expression from TISSUES for FLT4 Gene
- Bone marrow(4.3)
- Heart(3.2)
- Lymph node(2.8)
- Blood(2.4)
- Lung(2.4)
- Eye(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for FLT4 Gene
- ectoderm
- endoderm
- mesoderm
- cardiovascular
- digestive
- immune
- integumentary
- lymphatic
- reproductive
- ear
- eye
- eyelid
- face
- head
- heart
- intestine
- large intestine
- small intestine
- placenta
- testicle
- uterus
- digit
- finger
- foot
- hand
- lower limb
- nail
- toe
- upper limb
- blood
- blood vessel
- hair
- lymph node
- lymph vessel
- skin
Primer Products
-
OriGene qPCR primer pairs for FLT4
- genomics-online: primer clones - Search results for 105 available FLT4 gene related products
- Overview of 105 available FLT4 gene related products
Orthologs for FLT4 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | FLT4 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | FLT4 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | FLT4 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Flt4 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Flt4 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | FLT4 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
-- 34 |
|
OneToMany | |||
chicken (Gallus gallus) |
Aves | FLT4 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | FLT4 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100493801 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | flt4 33 34 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | tor 35 |
|
|
|
Cad96Ca 34 |
|
ManyToMany | |||
Pvr 34 |
|
ManyToMany | |||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for FLT4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FLT4 Gene
Paralogs for FLT4 Gene
(90) SIMAP similar genes for FLT4 Gene using alignment to 7 proteins:
- VEGFR3
- FLT-1
- RET
- CSF1R
- KIT
- KIF5B-RET(NM_020975)_K23
- R12
- KIF5B-RET(NM_020975)_K22
- R12
- KIF5B-RET(NM_020975)_K16
- R12
- KIF5B-RET(NM_020975)_K15
- R12
- KIF5B-RET(NM_020630)_K24
- R11
- KIF5B-RET(NM_020630)_K23
- R12
- KIF5B-RET(NM_020630)_K22
- R12
- KIF5B-RET(NM_020630)_K16
- R12
- KIF5B-RET(NM_020630)_K15
- R12
- CCDC6-RETc
- CCDC6-RETa
- TYRO3
- EGFR
- JAK2
- PTK2
- AXL
- ABL1
- MET
- MST1R
- TPM3-ROS1
- SLC34A2-ROS1
- SDC4-ROS1_S4
- R34
- SDC4-ROS1_S4
- R32
- SDC4-ROS1_S2
- R32
- LRIG3(NM_153377)-ROS1
- LRIG3(NM_001136051)-ROS1
- EZR-ROS1
- CD74-ROS1_C6
- R32
- FLT1
- FGFR1
- LTK
- EPHA6
- SQSTM1-ALK
- PPFIBP1-ALK
- KIF5B-ALK_K17
- A20
- ERBB2
- EML4-ALK
- ALK
- FES
- RYK
- TYK2
- NTRK1
- BLK
- TXK
- CAMKK2
- DKFZp686M05208
- BTK kinase deficient isoform 6
- KDR
- urf-ret
- RET/PTC2
- tec
- MERTK
- FGR
- NLK
- EPHA2
- BRAF
- TIE1
- MAPK3
- STK25
- FGFR2
- MAPK7
- CDK3
- CDK4
- CDKL3
- PAK1
- FGFR4
- VEGFR1
- TNIK
- MAP3K9
- CDK10
- RPS6KA2
Variants for FLT4 Gene
SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs121909650 | pathogenic, Hereditary lymphedema type I, Lymphedema, hereditary, 1A (LMPH1A) [MIM:153100] | 180,616,464(-) | C/G | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
rs121909651 | pathogenic, Hereditary lymphedema type I, Lymphedema, hereditary, 1A (LMPH1A) [MIM:153100] | 180,616,455(-) | A/G | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
rs121909652 | pathogenic, Hereditary lymphedema type I, Lymphedema, hereditary, 1A (LMPH1A) [MIM:153100] | 180,613,101(-) | G/A | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
rs121909653 | pathogenic, Hereditary lymphedema type I, Lymphedema, hereditary, 1A (LMPH1A) [MIM:153100] | 180,616,482(-) | T/C | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
rs121909654 | pathogenic, Hereditary lymphedema type I, Lymphedema, hereditary, 1A (LMPH1A) [MIM:153100] | 180,619,680(-) | C/T | coding_sequence_variant, missense_variant, non_coding_transcript_variant |
Additional Variant Information for FLT4 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLT4 Gene
Disorders for FLT4 Gene

(37) MalaCards diseases for FLT4 Gene - From: HGMD, OMIM, ClinVar, GTR, Swiss-Prot, DISEASES, Novoseek, and GeneCards
Disorder | Aliases | PubMed IDs |
---|---|---|
lymphedema, hereditary, ia |
|
|
hemangioma, capillary infantile |
|
|
lymphedema |
|
|
hereditary lymphedema |
|
|
hemangioma |
|
UniProtKB/Swiss-Prot
VGFR3_HUMAN- Hemangioma, capillary infantile (HCI) [MIM:602089]: A condition characterized by dull red, firm, dome-shaped hemangiomas, sharply demarcated from surrounding skin, usually presenting at birth or occurring within the first two or three months of life. They result from highly proliferative, localized growth of capillary endothelium and generally undergo regression and involution without scarring. {ECO:0000269 PubMed:11807987}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
- Lymphedema, hereditary, 1A (LMPH1A) [MIM:153100]: A chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections and physical impairment. {ECO:0000269 PubMed:10835628, ECO:0000269 PubMed:10856194, ECO:0000269 PubMed:12881528, ECO:0000269 PubMed:15102829, ECO:0000269 PubMed:16924388, ECO:0000269 PubMed:16965327, ECO:0000269 PubMed:17458866, ECO:0000269 PubMed:19289394, ECO:0000269 PubMed:26091405, ECO:0000269 PubMed:9817924}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Note=Plays an important role in tumor lymphangiogenesis, in cancer cell survival, migration, and formation of metastases.
Additional Disease Information for FLT4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for FLT4 Gene
Publications for FLT4 Gene
- Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene. (PMID: 1319394) Galland F … Birnbaum D (Genomics 1992) 2 3 4 22 58
- Recessive primary congenital lymphoedema caused by a VEGFR3 mutation. (PMID: 19289394) Ghalamkarpour A … Vikkula M (Journal of medical genetics 2009) 3 4 22 58
- Autocrine loop between vascular endothelial growth factor (VEGF)-C and VEGF receptor-3 positively regulates tumor-associated lymphangiogenesis in oral squamoid cancer cells. (PMID: 19779139) Matsuura M … Sueishi K (The American journal of pathology 2009) 3 4 22 58
- Analysis of the coding regions of VEGFR3 and VEGFC in Milroy disease and other primary lymphoedemas. (PMID: 19002718) Connell FC … Lymphoedema Consortium (Human genetics 2009) 3 22 44 58
- A novel VEGFR3 mutation causes Milroy disease. (PMID: 17458866) Butler MG … Glover TW (American journal of medical genetics. Part A 2007) 3 4 22 58
Products for FLT4 Gene
- R&D Systems Antibodies for FLT4 (VEGF R3/Flt-4)
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- RC600028
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- Cell Signaling Technology (CST) Antibodies for FLT4 (VEGFR3)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for FLT4
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- Novus Biologicals Antibodies for FLT4
- Novus Biologicals lysates for FLT4
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- Browse Knockouts at Cloud-Clone Corp.
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
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- Invitrogen Antibodies for FLT4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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- Addgene plasmids for FLT4
- antibodies-online: Search results for 13 available VGFR3 Antibodies ranked by validation data
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- antibodies-online: Search results for 48 available VGFR3 Elisa Kits ranked by validation data
- Compare Top VGFR3 Elisa Kits
- Recommended
- 2 Cow (Bovine) ELISA Kits
- 22 Human ELISA Kits
- 1 Monkey ELISA Kit
- 8 Mouse (Murine) ELISA Kits
- 1 Pig (Porcine) ELISA Kit
- 13 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- 2 Cow (Bovine) ELISA Kits
- 22 Human ELISA Kits
- 1 Monkey ELISA Kit
- 8 Mouse (Murine) ELISA Kits
- 1 Pig (Porcine) ELISA Kit
- 13 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- antibodies-online: Search results for 37 available VGFR3 Proteins ranked by validation data
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- GeneTex FLT4 antibody for FLT4
- Search GeneTex for Proteins for FLT4
- ViGene Biosciences adenoviral particle packaged cDNA for FLT4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FLT4 gene
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- genomics-online: cdna clones - Search results for 105 available VGFR3 gene related products
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- Overview of 105 available VGFR3 gene related products
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- Overview of 105 available VGFR3 gene related products
Sources for FLT4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
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- (125) NCBI Bookshelf
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- (128) ViGene Biosciences
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- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew