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Aliases for FLT4 Gene

Aliases for FLT4 Gene

  • Fms-Related Tyrosine Kinase 4 2 3
  • VEGFR3 3 4 6
  • Tyrosine-Protein Kinase Receptor FLT4 3 4
  • Fms-Like Tyrosine Kinase 4 3 4
  • EC 2.7.10.1 4 63
  • VEGFR-3 3 4
  • LMPH1A 3 6
  • FLT-4 3 4
  • PCL 3 6
  • Vascular Endothelial Growth Factor Receptor 3 3
  • Soluble VEGFR3 Variant 1 3
  • Soluble VEGFR3 Variant 2 3
  • Soluble VEGFR3 Variant 3 3
  • EC 2.7.10 63
  • FLT41 3

External Ids for FLT4 Gene

Previous GeneCards Identifiers for FLT4 Gene

  • GC05M180162
  • GC05M181012
  • GC05M180139
  • GC05M180132
  • GC05M179962
  • GC05M180028
  • GC05M174752

Summaries for FLT4 Gene

Entrez Gene Summary for FLT4 Gene

  • This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008]

GeneCards Summary for FLT4 Gene

FLT4 (Fms-Related Tyrosine Kinase 4) is a Protein Coding gene. Diseases associated with FLT4 include lymphedema, hereditary, ia and hereditary lymphedema. Among its related pathways are PI3K-Akt signaling pathway and RhoGDI Pathway. GO annotations related to this gene include protein phosphatase binding and growth factor binding. An important paralog of this gene is FGFR3.

UniProtKB/Swiss-Prot for FLT4 Gene

  • Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at Thr-183 and Tyr-185, and of AKT1 at Ser-473.

Tocris Summary for FLT4 Gene

  • Vascular endothelial growth factor is a signaling protein involved in the regulation of angiogenesis and vasculogenesis. VEGF binds to and activates a receptor tyrosine kinase, VEGFR. Three VEGFR isoforms have been identified in humans; VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1) and VEGFR-3 (Flt-4). VEGFR-2 mediates the majority of cellular responses to VEGF. VEGFR-1 is thought to modulate VEGFR-2 signaling or to act as a dummy/decoy receptor to sequester VEGF away from VEGFR-2.

Gene Wiki entry for FLT4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLT4 Gene

Genomics for FLT4 Gene

Regulatory Elements for FLT4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FLT4 Gene

Start:
180,601,506 bp from pter
End:
180,649,624 bp from pter
Size:
48,119 bases
Orientation:
Minus strand

Genomic View for FLT4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FLT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FLT4 Gene

Proteins for FLT4 Gene

  • Protein details for FLT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35916-VGFR3_HUMAN
    Recommended name:
    Vascular endothelial growth factor receptor 3
    Protein Accession:
    P35916
    Secondary Accessions:
    • A8K6L4
    • B5A926
    • Q16067
    • Q86W07
    • Q86W08

    Protein attributes for FLT4 Gene

    Size:
    1363 amino acids
    Molecular mass:
    152757 Da
    Quaternary structure:
    • Interacts with VEGFC and VEGFD. Monomer in the absence of bound VEGFC or VEGFD. Homodimer in the presence of bound VEGFC or VEGFD. Can also form a heterodimer with KDR. Interacts with PTPN14; the interaction is enhanced by stimulation with VEGFC. Interacts with CRK, GRB2, PTK2/FAK1, SHC1, PIK3R1 and PTPN11/SHP-2. Identified in a complex with SRC and ITGB1.
    SequenceCaution:
    • Sequence=CAA48290.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FLT4 Gene

    Alternative splice isoforms for FLT4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FLT4 Gene

Proteomics data for FLT4 Gene at MOPED

Post-translational modifications for FLT4 Gene

  • Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation in response to H(2)O(2) is mediated by a process that requires SRC and PRKCD activity. Phosphorylation at Tyr-1068 is required for autophosphorylation at additional tyrosine residues. Phosphorylation at Tyr-1063 and Tyr-1337 is important for interaction with CRK and subsequent activation of MAPK8. Phosphorylation at Tyr-1230, Tyr-1231 and Tyr-1337 is important for interaction with GRB2 and subsequent activation of the AKT1 and MAPK1/ERK2 and/or MAPK3/ERK1 signaling pathways. In response to endothelial cell adhesion onto collagen, can also be phosphorylated in the absence of FLT4 kinase activity by SRC at Tyr-830, Tyr-833, Tyr-853, Tyr-1063, Tyr-1333, and Tyr-1337.
  • Ubiquitination at Lys1253
  • Glycosylation at Asn33, Asn104, Asn166, Asn251, Asn299, Asn411, Asn515, Asn527, Asn594, Asn683, Asn690, and Asn758
  • Modification sites at PhosphoSitePlus

Other Protein References for FLT4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FLT4 (VEGFR3)

Domains for FLT4 Gene

Suggested Antigen Peptide Sequences for FLT4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35916

UniProtKB/Swiss-Prot:

VGFR3_HUMAN :
  • The first and second Ig-like C2-type (immunoglobulin-like) domains are sufficient for VEGFC binding
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Domain:
  • The first and second Ig-like C2-type (immunoglobulin-like) domains are sufficient for VEGFC binding
  • Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
genes like me logo Genes that share domains with FLT4: view

Function for FLT4 Gene

Molecular function for FLT4 Gene

GENATLAS Biochemistry:
fms-related receptor t tyrosine kinase 4,expressed on the surface on endothelial cells
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Present in an inactive conformation in the absence of bound ligand. Binding of VEGFC or VEGFD leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by MAZ51.
UniProtKB/Swiss-Prot Function:
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at Thr-183 and Tyr-185, and of AKT1 at Ser-473.

Enzyme Numbers (IUBMB) for FLT4 Gene

Gene Ontology (GO) - Molecular Function for FLT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity --
GO:0004714 transmembrane receptor protein tyrosine kinase activity IMP 7898938
GO:0005021 vascular endothelial growth factor-activated receptor activity IMP 11532940
GO:0005515 protein binding IPI 16530705
genes like me logo Genes that share ontologies with FLT4: view
genes like me logo Genes that share phenotypes with FLT4: view

Animal Model Products

miRNA for FLT4 Gene

miRTarBase miRNAs that target FLT4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FLT4

Clone Products

  • Addgene plasmids for FLT4

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for FLT4 Gene

Localization for FLT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLT4 Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Note=Ligand-mediated autophosphorylation leads to rapid internalization.
Isoform 1: Cell membrane; Single-pass type I membrane protein. Note=Ligand-mediated autophosphorylation leads to rapid internalization.
Isoform 2: Cell membrane; Single-pass type I membrane protein.
Isoform 3: Secreted. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FLT4 Gene COMPARTMENTS Subcellular localization image for FLT4 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 5
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FLT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
genes like me logo Genes that share ontologies with FLT4: view

Pathways for FLT4 Gene

genes like me logo Genes that share pathways with FLT4: view

PCR Array Products

Gene Ontology (GO) - Biological Process for FLT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IMP 11532940
GO:0001938 positive regulation of endothelial cell proliferation IMP 11532940
GO:0001944 vasculature development ISS --
GO:0001945 lymph vessel development ISS --
GO:0001946 lymphangiogenesis ISS --
genes like me logo Genes that share ontologies with FLT4: view

Drugs for FLT4 Gene

(11) Drugbank Compounds for FLT4 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
Axitinib
  • SID103905539
319460-85-0 Target inhibitor approved, investigational
Sorafenib
  • 4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide
284461-73-0 216239 Target antagonist approved, investigational
Sunitinib
  • SU-11248
557795-19-4 5329102 Target antagonist approved, investigational
Lenvatinib
  • 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide
417716-92-8 Target Inhibitor approved
Nintedanib
  • methyl (3Z)-3-[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}anilino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
656247-17-5 Target Inhibitor approved

(5) Tocris Compounds for FLT4 Gene

Compound Action Cas Number
Axitinib Potent VEGFR-1, -2 and -3 inhibitor [319460-85-0]
EG 00229 Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1 [1018927-63-3]
Sunitinib malate Potent VEGFR, PDGFRbeta and KIT inhibitor [341031-54-7]
ZM 306416 hydrochloride Inhibitor of VEGF receptor tyrosine kinase [196603-47-1]
ZM 323881 hydrochloride Potent, selective inhibitor of VEGFR-2 [193000-39-4]

(19) ApexBio Compounds for FLT4 Gene

Compound Action Cas Number
BIBF 1120 VEGFR/PDGF/FGFR inhibitor [656247-17-5]
Cabozantinib (XL184, BMS-907351) VEGFR2/Met/Ret/Kit/FLT//AXL inhibitor [849217-68-1]
Cediranib (AZD217) VEGFR inhibitor receptor,highly potent [288383-20-0]
Dovitinib Dilactic acid [852433-84-2]
Foretinib (GSK1363089) VEGF and HGF receptor inhibitor [849217-64-7]
Ki8751 VEGFR-2 inhibitor,potent and selective [228559-41-9]
KRN 633 VEGFR inhibitor,ATP-competitive [286370-15-8]
Lenvatinib (E7080) VEGFR inhibitor [417716-92-8]
Motesanib Diphosphate (AMG-706) VEGFR/ PDGFR/c-Kit/Ret inhibitor [857876-30-3]
Pazopanib (GW-786034) VEGFR/PDGFR/FGFR inhibitor [635702-64-6]
Pazopanib Hydrochloride VEGFR/PDGFR/FGFR/c-Kit/ c-Fms inhibitor [635702-64-6]
PD 173074 FGFR inhibitor [219580-11-7]
SAR131675 VEGFR3 inhibitor,selective and ATP-competitve [1433953-83-3]
SKLB610 Potent VEGFR inhibitor [1125780-41-7]
SU 4312 [5812-7-7]
Sunitinib RTK inhibitor [557795-19-4]
Telatinib (BAY 57-9352) VEGFR-2/-3,PDGFR-β and c-Kit inhibitor [332012-40-5]
Tivozanib (AV-951) VEGFR inhibitor,potent and selective [475108-18-0]
Vatalanib (PTK787) 2HCl Tyrosine kinase receptor inhibitor [212141-51-0]

(4) HMDB Compounds for FLT4 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(Tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • Adenosindiphosphorsaeure
58-64-0
Sorafenib
  • Sorafenib tosylate
284461-73-0
Sunitinib
  • SU11248
557795-19-4

(3) IUPHAR Ligand for FLT4 Gene

Ligand Type Action Affinity Pubmed IDs
VEGFC None None
VEGFE None None
VEGFD None None

(16) Novoseek inferred chemical compound relationships for FLT4 Gene

Compound -log(P) Hits PubMed IDs
vegf 87.8 144
azd 2171 78.4 2
tyrosine 66.8 94
zd6474 64.2 1
sorafenib 50.5 6

(3) PharmGKB related drug/compound annotations for FLT4 Gene

Drug/compound Annotation
pazopanib Clinical Annotation,DrugLabel
regorafenib Clinical Annotation,DrugLabel
sunitinib Clinical Annotation,DrugLabel
genes like me logo Genes that share compounds with FLT4: view

Compound Products

Transcripts for FLT4 Gene

Unigene Clusters for FLT4 Gene

Fms-related tyrosine kinase 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FLT4

Clone Products

  • Addgene plasmids for FLT4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FLT4 Gene

No ASD Table

Relevant External Links for FLT4 Gene

GeneLoc Exon Structure for
FLT4
ECgene alternative splicing isoforms for
FLT4

Expression for FLT4 Gene

mRNA expression in normal human tissues for FLT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FLT4 Gene

This gene is overexpressed in Thyroid (4.3).

Protein differential expression in normal tissues for FLT4 Gene

This gene is overexpressed in Serum (56.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FLT4 Gene

SOURCE GeneReport for Unigene cluster for FLT4 Gene Hs.646917

mRNA Expression by UniProt/SwissProt for FLT4 Gene

P35916-VGFR3_HUMAN
Tissue specificity: Detected in endothelial cells (at protein level). Widely expressed. Detected in fetal spleen, lung and brain. Detected in adult liver, muscle, thymus, placenta, lung, testis, ovary, prostate, heart, and kidney.
genes like me logo Genes that share expressions with FLT4: view

Expression partners for FLT4 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for FLT4 Gene

This gene was present in the common ancestor of animals.

Orthologs for FLT4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FLT4 35
  • 86.47 (n)
  • 86.47 (a)
FLT4 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FLT4 35
  • 88.15 (n)
  • 88.55 (a)
FLT4 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Flt4 35
  • 85.3 (n)
  • 87.45 (a)
Flt4 16
Flt4 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FLT4 35
  • 98.56 (n)
  • 98.75 (a)
FLT4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Flt4 35
  • 84.98 (n)
  • 87.09 (a)
oppossum
(Monodelphis domestica)
Mammalia FLT4 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 71 (a)
OneToMany
-- 36
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves FLT4 35
  • 72.13 (n)
  • 70.92 (a)
FLT4 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FLT4 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493801 35
  • 63.74 (n)
  • 64.64 (a)
zebrafish
(Danio rerio)
Actinopterygii flt4 35
  • 60.63 (n)
  • 56.82 (a)
flt4 36
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta tor 37
  • 50 (a)
Cad96Ca 36
  • 28 (a)
ManyToMany
Pvr 36
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for FLT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FLT4 Gene

ENSEMBL:
Gene Tree for FLT4 (if available)
TreeFam:
Gene Tree for FLT4 (if available)

Paralogs for FLT4 Gene

Paralogs for FLT4 Gene

genes like me logo Genes that share paralogs with FLT4: view

Variants for FLT4 Gene

Sequence variations from dbSNP and Humsavar for FLT4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs59338603 -- 180,614,706(+) ACTGG(-/C)CCTCT intron-variant
rs59410886 -- 180,630,538(+) CTGGC(C/T)CGCCT intron-variant
rs59769082 -- 180,651,357(+) TTTTT(G/T)TTGTT upstream-variant-2KB
rs59206179 -- 180,615,195(+) GGCCC(C/T)GCTGG intron-variant
rs58573467 -- 180,624,814(+) CAAGC(C/T)TGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FLT4 Gene

Variant ID Type Subtype PubMed ID
nsv509111 CNV Insertion 20534489
dgv6404n71 CNV Loss 21882294
dgv6405n71 CNV Loss 21882294
nsv462585 CNV Loss 19166990
nsv883296 CNV Gain 21882294
nsv528843 CNV Loss 19592680
nsv883297 CNV Loss 21882294
esv1734970 CNV Insertion 17803354
nsv528522 CNV Loss 19592680
esv27625 CNV Gain+Loss 19812545
esv2731345 CNV Deletion 23290073
nsv328308 CNV Loss 16902084
esv1125232 CNV Insertion 17803354
esv2731346 CNV Deletion 23290073
esv1677986 CNV Insertion 17803354
esv2731347 CNV Deletion 23290073
esv1000883 CNV Loss 20482838
nsv820663 CNV Deletion 20802225
nsv883298 CNV Loss 21882294
nsv522563 CNV Loss 19592680
esv1049221 CNV Deletion 17803354
esv2387627 CNV Deletion 18987734
esv4093 CNV Deletion 18987735
esv2731348 CNV Deletion 23290073
esv2665740 CNV Deletion 23128226
nsv830565 CNV Loss 17160897

Relevant External Links for FLT4 Gene

HapMap Linkage Disequilibrium report
FLT4
Human Gene Mutation Database (HGMD)
FLT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLT4 Gene

Disorders for FLT4 Gene

(2) OMIM Diseases for FLT4 Gene (136352)

UniProtKB/Swiss-Prot

VGFR3_HUMAN
  • Lymphedema, hereditary, 1A (LMPH1A) [MIM:153100]: A chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections and physical impairment. {ECO:0000269 PubMed:10835628, ECO:0000269 PubMed:10856194, ECO:0000269 PubMed:9817924}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Hemangioma, capillary infantile (HCI) [MIM:602089]: A condition characterized by dull red, firm, dome-shaped hemangiomas, sharply demarcated from surrounding skin, usually presenting at birth or occurring within the first two or three months of life. They result from highly proliferative, localized growth of capillary endothelium and generally undergo regression and involution without scarring. {ECO:0000269 PubMed:11807987}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Note=Plays an important role in tumor lymphangiogenesis, in cancer cell survival, migration, and formation of metastases.

(2) University of Copenhagen DISEASES for FLT4 Gene

(79) Novoseek inferred disease relationships for FLT4 Gene

Disease -log(P) Hits PubMed IDs
congenital lymphedema 89.3 27
lymphatic metastasis 85.5 14
lymphedema primary 79.9 3
lymphedema 76.4 20
metastasis 68.1 83

Relevant External Links for FLT4

GeneTests
FLT4
GeneReviews
FLT4
Genetic Association Database (GAD)
FLT4
Human Genome Epidemiology (HuGE) Navigator
FLT4
genes like me logo Genes that share disorders with FLT4: view

No data available for Genatlas for FLT4 Gene

Publications for FLT4 Gene

  1. Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene. (PMID: 1319394) Galland F. … Birnbaum D. (Genomics 1992) 2 3 4 23
  2. Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma. (PMID: 11807987) Walter J.W. … Marchuk D.A. (Genes Chromosomes Cancer 2002) 3 4 23
  3. Heterodimerization with vascular endothelial growth factor receptor-2 (VEGFR-2) is necessary for VEGFR-3 activity. (PMID: 15474514) Alam A. … Herbert J.M. (Biochem. Biophys. Res. Commun. 2004) 3 4 23
  4. Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells. (PMID: 16452200) Garces C.A. … Cance W.G. (Cancer Res. 2006) 3 4 23
  5. Analysis of the coding regions of VEGFR3 and VEGFC in Milroy disease and other primary lymphoedemas. (PMID: 19002718) Connell F.C. … Jeffery S. (Hum. Genet. 2009) 3 23 48

Products for FLT4 Gene

  • Addgene plasmids for FLT4

Sources for FLT4 Gene

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