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FLT4 Gene(Protein Coding)

Fms Related Tyrosine Kinase 4

GCID:
GC05M180607
GIFtS:
64
Genes Participants
UDN Logo

Aliases for FLT4 Gene

Aliases for FLT4 Gene

  • Fms Related Tyrosine Kinase 4 2 3 5
  • Tyrosine-Protein Kinase Receptor FLT4 3 4
  • Fms-Like Tyrosine Kinase 4 3 4
  • EC 2.7.10.1 4 56
  • VEGFR-3 3 4
  • VEGFR3 3 4
  • FLT-4 3 4
  • Vascular Endothelial Growth Factor Receptor 3 3
  • Fms-Related Tyrosine Kinase 4 2
  • EC 2.7.10 56
  • LMPH1A 3
  • FLT41 3
  • PCL 3

External Ids for FLT4 Gene

Previous GeneCards Identifiers for FLT4 Gene

  • GC05M180162
  • GC05M181012
  • GC05M180139
  • GC05M180132
  • GC05M179962
  • GC05M180028
  • GC05M174752

Summaries for FLT4 Gene

Entrez Gene Summary for FLT4 Gene

  • This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008]

CIViC summary for FLT4 Gene

GeneCards Summary for FLT4 Gene

FLT4 (Fms Related Tyrosine Kinase 4) is a Protein Coding gene. Diseases associated with FLT4 include Lymphedema, Hereditary, Ia and Hemangioma, Capillary Infantile. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is KDR.

UniProtKB/Swiss-Prot for FLT4 Gene

  • Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at Thr-183 and Tyr-185, and of AKT1 at Ser-473.

Tocris Summary for FLT4 Gene

  • Vascular endothelial growth factor is a signaling protein involved in the regulation of angiogenesis and vasculogenesis. VEGF binds to and activates a receptor tyrosine kinase, VEGFR, through transphosphorylation. Three VEGFR isoforms have been identified in humans.

Gene Wiki entry for FLT4 Gene

Additional gene information for FLT4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLT4 Gene

Genomics for FLT4 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for FLT4 Gene

Promoters and enhancers for FLT4 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH05I180649 Promoter 1.5 EPDnew Ensembl 550.8 +0.8 770 0.6 CTCF MAZ ZBTB6 L3MBTL2 ZNF189 ZNF398 ZEB2 ZIC2 ZNF335 CTBP2 FLT4 PIR50427 GC05M180610
GH05I180618 Promoter 1 Ensembl 11.9 +31.2 31170 0.6 CTCF MXI1 ZIC2 ZNF335 FOXM1 E2F1 ZFHX2 GLIS2 POLR2A ZBTB48 FLT4 GC05M180610 PIR50427
GH05I180560 Enhancer 0.9 ENCODE 12 +87.8 87782 3.6 HDGF HDAC1 PKNOX1 ARNT TCF12 GATA2 ZNF143 SIRT6 ATF7 RUNX3 SCGB3A1 FLT4 CNOT6 ENSG00000248367 GC05P180580 LOC100329129
GH05I180688 Enhancer 0.9 FANTOM5 Ensembl ENCODE 11.7 -39.5 -39482 3.3 ZNF335 RNF2 BMI1 ZFX EZH2 EGR2 GC05P181026 GC05P181038 PIR40400 PIR57207 PIR46573 FLT4 OR2Y1 MGAT1 GC05P181030 PIR39363
GH05I180623 Enhancer 0.5 Ensembl 12.4 +26.8 26770 0.6 ATF1 GABPB1 CREB1 NR2F2 SPI1 FLT4 GC05M180610 PIR50427
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FLT4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FLT4 gene promoter:

Genomic Locations for FLT4 Gene

Genomic Locations for FLT4 Gene
chr5:180,601,506-180,650,271
(GRCh38/hg38)
Size:
48,766 bases
Orientation:
Minus strand
chr5:180,028,506-180,076,624
(GRCh37/hg19)

Genomic View for FLT4 Gene

Genes around FLT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FLT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FLT4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FLT4 Gene

Proteins for FLT4 Gene

Products:

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  • Protein details for FLT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35916-VGFR3_HUMAN
    Recommended name:
    Vascular endothelial growth factor receptor 3
    Protein Accession:
    P35916
    Secondary Accessions:
    • A8K6L4
    • B5A926
    • Q16067
    • Q86W07
    • Q86W08

    Protein attributes for FLT4 Gene

    Size:
    1363 amino acids
    Molecular mass:
    152757 Da
    Quaternary structure:
    • Interacts with VEGFC and VEGFD. Monomer in the absence of bound VEGFC or VEGFD. Homodimer in the presence of bound VEGFC or VEGFD. Can also form a heterodimer with KDR. Interacts with PTPN14; the interaction is enhanced by stimulation with VEGFC. Interacts with CRK, GRB2, PTK2/FAK1, SHC1, PIK3R1 and PTPN11/SHP-2. Identified in a complex with SRC and ITGB1.
    SequenceCaution:
    • Sequence=CAA48290.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FLT4 Gene

    Alternative splice isoforms for FLT4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FLT4 Gene

Protein Expression for FLT4 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for FLT4 Gene

P35916:
  • GTRMRAP
  • KMLKEGAT
  • QDAVNPIES
  • QTHTELSSILT
  • QVARGME
  • GMEFLASRKCIHRDLAARNILLS
  • RLPLKWMAPE
  • RDLAARN
  • CRGQHPLEW
  • YLCSVCNAKGCVNSSASV
  • YLSIIMDP
  • VAVKMLK
  • HLNVVNLLGACTK
  • HSLAARYYN
  • ALMSELK
  • WEIFSLG
  • KTGYLSI
  • KICDFGLARD
  • DSGMVLASEE
  • KWMAPESIF
  • FSLGASPYP
  • WVPCLVSIP
  • KHCHKKY
  • SRKCIHRDLAARNILLSE
  • ANVSAMYKC
  • LSIQRVREEDAG
  • NKTVSKL
  • GPLMVIVE
  • SSPSIYSR
  • LDCKNVH
  • YSMTPPTL
  • CKYGNLSN
  • DERLIYFYVTTIP
  • PDYVRKG
  • DFGLARDI
  • VNVPPQI
  • CYSFQVA

Post-translational modifications for FLT4 Gene

  • Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation in response to H(2)O(2) is mediated by a process that requires SRC and PRKCD activity. Phosphorylation at Tyr-1068 is required for autophosphorylation at additional tyrosine residues. Phosphorylation at Tyr-1063 and Tyr-1337 is important for interaction with CRK and subsequent activation of MAPK8. Phosphorylation at Tyr-1230, Tyr-1231 and Tyr-1337 is important for interaction with GRB2 and subsequent activation of the AKT1 and MAPK1/ERK2 and/or MAPK3/ERK1 signaling pathways. In response to endothelial cell adhesion onto collagen, can also be phosphorylated in the absence of FLT4 kinase activity by SRC at Tyr-830, Tyr-833, Tyr-853, Tyr-1063, Tyr-1333, and Tyr-1337.
  • Ubiquitination at Lys1253
  • Glycosylation at Asn33, Asn104, posLast=166166, Asn251, Asn299, Asn411, Asn515, Asn527, Asn594, posLast=683683, posLast=690690, and Asn758

Other Protein References for FLT4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for FLT4 Gene

Gene Families for FLT4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for FLT4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FLT4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35916

UniProtKB/Swiss-Prot:

VGFR3_HUMAN :
  • The first and second Ig-like C2-type (immunoglobulin-like) domains are sufficient for VEGFC binding (PubMed:23878260). The fourth and fifth Ig-like C2-type domains are sufficient for homodimerization (PubMed:23878260). The fifth and seventh Ig-like C2-type domains are required for autophosphorylation and further activation (PubMed:23878260).
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Domain:
  • The first and second Ig-like C2-type (immunoglobulin-like) domains are sufficient for VEGFC binding (PubMed:23878260). The fourth and fifth Ig-like C2-type domains are sufficient for homodimerization (PubMed:23878260). The fifth and seventh Ig-like C2-type domains are required for autophosphorylation and further activation (PubMed:23878260).
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
genes like me logo Genes that share domains with FLT4: view

Function for FLT4 Gene

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  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for FLT4 Gene

GENATLAS Biochemistry:
fms-related receptor t tyrosine kinase 4,expressed on the surface on endothelial cells
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Present in an inactive conformation in the absence of bound ligand. Binding of VEGFC or VEGFD leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by MAZ51.
UniProtKB/Swiss-Prot Function:
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at Thr-183 and Tyr-185, and of AKT1 at Ser-473.

Enzyme Numbers (IUBMB) for FLT4 Gene

Gene Ontology (GO) - Molecular Function for FLT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0004714 transmembrane receptor protein tyrosine kinase activity IEA,IMP 7898938
GO:0005021 vascular endothelial growth factor-activated receptor activity IEA,IMP 11532940
GO:0005515 protein binding IPI 16530705
genes like me logo Genes that share ontologies with FLT4: view
genes like me logo Genes that share phenotypes with FLT4: view

Human Phenotype Ontology for FLT4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FLT4 Gene

MGI Knock Outs for FLT4:

miRNA for FLT4 Gene

miRTarBase miRNAs that target FLT4

Clone Products

  • Addgene plasmids for FLT4

No data available for Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for FLT4 Gene

Localization for FLT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLT4 Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Note=Ligand-mediated autophosphorylation leads to rapid internalization. {ECO:0000269 PubMed:20445537}.
Isoform 1: Cell membrane; Single-pass type I membrane protein. Note=Ligand-mediated autophosphorylation leads to rapid internalization.
Isoform 2: Cell membrane; Single-pass type I membrane protein.
Isoform 3: Secreted. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FLT4 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 4
cytoskeleton 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (4)
  • Plasma membrane (4)
  • Cell Junctions (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FLT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with FLT4: view

Pathways & Interactions for FLT4 Gene

genes like me logo Genes that share pathways with FLT4: view

SIGNOR curated interactions for FLT4 Gene

Activates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for FLT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001934 positive regulation of protein phosphorylation IMP 11532940
GO:0001938 positive regulation of endothelial cell proliferation IMP 11532940
GO:0001944 vasculature development ISS --
GO:0001945 lymph vessel development ISS --
genes like me logo Genes that share ontologies with FLT4: view

Drugs & Compounds for FLT4 Gene

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  1. Drug

(85) Drugs for FLT4 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sunitinib Approved, Investigational Pharma Target, inhibitor VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor, RTK inhibitor, Potent VEGFR, PDGFRbeta and KIT inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 518
Sorafenib Approved, Investigational Pharma Target, antagonist, inhibitors, inhibitor Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 717
Pazopanib Approved Pharma Target, inhibitor VEFGR, c-Kit, and PDGFR inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
regorafenib Approved Pharma Target, inhibitor Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Axitinib Approved, Investigational Pharma Target, inhibitor, Inhibition Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 116

(10) Additional Compounds for FLT4 Gene - From: Novoseek, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
 Full agonist, Agonist 58-64-0
XL 184
849217-68-1

(4) Tocris Compounds for FLT4 Gene

Compound Action Cas Number
SU 4312 Potent inhibitor of VEGFR tyrosine kinase 5812-07-7
SU 5416 VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3 204005-46-9
Sunitinib malate Potent VEGFR, PDGFRbeta and KIT inhibitor 341031-54-7
XL 184 Potent VEGFR inhibitor; also inhibits other RTKs 849217-68-1

(30) ApexBio Compounds for FLT4 Gene

Compound Action Cas Number
(E)-FeCP-oxindole 884338-18-5
(Z)-FeCP-oxindole 1137967-28-2
BIBF 1120 VEGFR/PDGF/FGFR inhibitor 656247-17-5
Cabozantinib (XL184, BMS-907351) VEGFR2/Met/Ret/Kit/FLT//AXL inhibitor 849217-68-1
Cediranib (AZD217) VEGFR inhibitor receptor,highly potent 288383-20-0
DMH4 515880-75-8
Dovitinib (TKI258) Lactate Oral tyrosine kinase inhibitor (TKI) against FGFR1–3, VEGFR1–3, and platelet-derived growth factor receptor (PDGFR) 915769-50-5
Dovitinib (TKI-258, CHIR-258) Multitargeted RTK inhibitor 405169-16-6
Dovitinib Dilactic acid 852433-84-2
Foretinib (GSK1363089) VEGF and HGF receptor inhibitor 849217-64-7
Fruquintinib(HMPL-013) Potent and selective inhibitor of VEGFR 1, 2, 3 1194506-26-7
Ki8751 VEGFR-2 inhibitor,potent and selective 228559-41-9
KRN 633 VEGFR inhibitor,ATP-competitive 286370-15-8
Lenvatinib (E7080) VEGFR inhibitor 417716-92-8
Linifanib (ABT-869) VEGFR/PDGFR inhibitor 796967-16-3
MGCD-265 Met/Flt/Flk/Ron/Tie-2 inhibitor 875337-44-3
Motesanib Diphosphate (AMG-706) VEGFR/ PDGFR/c-Kit/Ret inhibitor 857876-30-3
Pazopanib (GW-786034) VEGFR/PDGFR/FGFR inhibitor 635702-64-6
Pazopanib Hydrochloride VEGFR/PDGFR/FGFR/c-Kit/ c-Fms inhibitor 635702-64-6
PD 173074 FGFR inhibitor 219580-11-7
SAR131675 VEGFR3 inhibitor,selective and ATP-competitve 1433953-83-3
SKLB610 Potent VEGFR inhibitor 1125780-41-7
SU 4312 5812-07-7
Sunitinib RTK inhibitor 557795-19-4
Sunitinib malate VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor 341031-54-7
Telatinib (BAY 57-9352) VEGFR-2/-3,PDGFR-β and c-Kit inhibitor 332012-40-5
Tivozanib (AV-951) VEGFR inhibitor,potent and selective 475108-18-0
Vatalanib VEGFR-1/-2 inhibitor,cell-permeable 212141-54-3
Vatalanib (PTK787) 2HCl Tyrosine kinase receptor inhibitor 212141-51-0
ZM 306416 VEGFR (Flt and KDR) inhibitor 690206-97-4
genes like me logo Genes that share compounds with FLT4: view

Drug Products

Transcripts for FLT4 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for FLT4 Gene

(11) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(96) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FLT4 Gene

Fms-related tyrosine kinase 4:
Representative Sequences:

Clone Products

  • Addgene plasmids for FLT4

Alternative Splicing Database (ASD) splice patterns (SP) for FLT4 Gene

No ASD Table

Relevant External Links for FLT4 Gene

GeneLoc Exon Structure for
FLT4
ECgene alternative splicing isoforms for
FLT4

Expression for FLT4 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FLT4 Gene

mRNA expression in normal human tissues for FLT4 Gene
mRNA expression by BioGPS for FLT4 GenemRNA expression by GTEx for FLT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FLT4 Gene

This gene is overexpressed in Thyroid (x4.3).

Protein differential expression in normal tissues from HIPED for FLT4 Gene

This gene is overexpressed in Serum (56.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FLT4 Gene



Protein tissue co-expression partners for FLT4 Gene

NURSA nuclear receptor signaling pathways regulating expression of FLT4 Gene:

FLT4

SOURCE GeneReport for Unigene cluster for FLT4 Gene:

Hs.646917

mRNA Expression by UniProt/SwissProt for FLT4 Gene:

P35916-VGFR3_HUMAN
Tissue specificity: Detected in endothelial cells (at protein level). Widely expressed. Detected in fetal spleen, lung and brain. Detected in adult liver, muscle, thymus, placenta, lung, testis, ovary, prostate, heart, and kidney.

Evidence on tissue expression from TISSUES for FLT4 Gene

  • Bone marrow(4.3)
  • Heart(3.2)
  • Lymph node(2.8)
  • Blood(2.4)
  • Lung(2.4)
  • Eye(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for FLT4 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • reproductive
Organs:
Head and neck:
  • ear
  • eye
  • eyelid
  • face
  • head
Thorax:
  • heart
Abdomen:
  • intestine
  • large intestine
  • small intestine
Pelvis:
  • placenta
  • testicle
  • uterus
Limb:
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • nail
  • toe
  • upper limb
General:
  • blood
  • blood vessel
  • hair
  • lymph node
  • lymph vessel
  • skin
genes like me logo Genes that share expression patterns with FLT4: view

Orthologs for FLT4 Gene

This gene was present in the common ancestor of animals.

Orthologs for FLT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FLT4 33 34
  • 98.56 (n)
dog
(Canis familiaris)
 Mammalia FLT4 33 34
  • 88.15 (n)
cow
(Bos Taurus)
 Mammalia FLT4 33 34
  • 86.47 (n)
mouse
(Mus musculus)
 Mammalia Flt4 33 16 34
  • 85.3 (n)
rat
(Rattus norvegicus)
 Mammalia Flt4 33
  • 84.98 (n)
oppossum
(Monodelphis domestica)
 Mammalia FLT4 34
  • 76 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 71 (a)
 OneToMany
-- 34
  • 69 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves FLT4 33 34
  • 72.13 (n)
lizard
(Anolis carolinensis)
 Reptilia FLT4 34
  • 67 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100493801 33
  • 63.74 (n)
zebrafish
(Danio rerio)
 Actinopterygii flt4 33 34
  • 60.63 (n)
fruit fly
(Drosophila melanogaster)
 Insecta tor 35
  • 50 (a)
Cad96Ca 34
  • 28 (a)
 ManyToMany
Pvr 34
  • 21 (a)
 ManyToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 35 (a)
 OneToMany
Species where no ortholog for FLT4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FLT4 Gene

ENSEMBL:
Gene Tree for FLT4 (if available)
TreeFam:
Gene Tree for FLT4 (if available)

Paralogs for FLT4 Gene

Paralogs for FLT4 Gene

(90) SIMAP similar genes for FLT4 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with FLT4: view

Variants for FLT4 Gene

Sequence variations from dbSNP and Humsavar for FLT4 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs121909650 pathogenic, Hereditary lymphedema type I, Lymphedema, hereditary, 1A (LMPH1A) [MIM:153100] 180,616,464(-) C/G coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs121909651 pathogenic, Hereditary lymphedema type I, Lymphedema, hereditary, 1A (LMPH1A) [MIM:153100] 180,616,455(-) A/G coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs121909652 pathogenic, Hereditary lymphedema type I, Lymphedema, hereditary, 1A (LMPH1A) [MIM:153100] 180,613,101(-) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs121909653 pathogenic, Hereditary lymphedema type I, Lymphedema, hereditary, 1A (LMPH1A) [MIM:153100] 180,616,482(-) T/C coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs121909654 pathogenic, Hereditary lymphedema type I, Lymphedema, hereditary, 1A (LMPH1A) [MIM:153100] 180,619,680(-) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FLT4 Gene

Variant ID Type Subtype PubMed ID
esv1000883 CNV loss 20482838
esv1049221 CNV deletion 17803354
esv1125232 CNV insertion 17803354
esv1677986 CNV insertion 17803354
esv1734970 CNV insertion 17803354
esv2387627 CNV deletion 18987734
esv2665740 CNV deletion 23128226
esv2731345 CNV deletion 23290073
esv2731346 CNV deletion 23290073
esv2731347 CNV deletion 23290073
esv2731348 CNV deletion 23290073
esv27625 CNV gain+loss 19812545
esv2762572 CNV gain 21179565
esv3607788 CNV loss 21293372
esv4093 CNV loss 18987735
nsv1026417 CNV gain 25217958
nsv1074357 CNV deletion 25765185
nsv1109754 CNV deletion 24896259
nsv1129755 CNV tandem duplication 24896259
nsv1148274 CNV deletion 26484159
nsv328308 CNV deletion 16902084
nsv462585 CNV loss 19166990
nsv509111 CNV insertion 20534489
nsv522563 CNV loss 19592680
nsv528522 CNV loss 19592680
nsv528843 CNV loss 19592680
nsv600669 CNV loss 21841781
nsv600670 CNV loss 21841781
nsv820663 CNV deletion 20802225
nsv830565 CNV loss 17160897
nsv950740 CNV deletion 24416366

Variation tolerance for FLT4 Gene

Residual Variation Intolerance Score: 17.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.66; 72.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FLT4 Gene

Human Gene Mutation Database (HGMD)
FLT4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FLT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLT4 Gene

Disorders for FLT4 Gene

MalaCards: The human disease database

(37) MalaCards diseases for FLT4 Gene - From: HGMD, OMIM, ClinVar, GTR, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lymphedema, hereditary, ia
  • lmph1a
hemangioma, capillary infantile
  • hci
lymphedema
  • lymphatic edema
hereditary lymphedema
  • nonne-milroy lymphedema
hemangioma
- elite association - COSMIC cancer census association via MalaCards
Search FLT4 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

VGFR3_HUMAN
  • Hemangioma, capillary infantile (HCI) [MIM:602089]: A condition characterized by dull red, firm, dome-shaped hemangiomas, sharply demarcated from surrounding skin, usually presenting at birth or occurring within the first two or three months of life. They result from highly proliferative, localized growth of capillary endothelium and generally undergo regression and involution without scarring. {ECO:0000269 PubMed:11807987}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Lymphedema, hereditary, 1A (LMPH1A) [MIM:153100]: A chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections and physical impairment. {ECO:0000269 PubMed:10835628, ECO:0000269 PubMed:10856194, ECO:0000269 PubMed:12881528, ECO:0000269 PubMed:15102829, ECO:0000269 PubMed:16924388, ECO:0000269 PubMed:16965327, ECO:0000269 PubMed:17458866, ECO:0000269 PubMed:19289394, ECO:0000269 PubMed:26091405, ECO:0000269 PubMed:9817924}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=Plays an important role in tumor lymphangiogenesis, in cancer cell survival, migration, and formation of metastases.

Additional Disease Information for FLT4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FLT4: view

No data available for Genatlas for FLT4 Gene

Publications for FLT4 Gene

  1. Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene. (PMID: 1319394) Galland F … Birnbaum D (Genomics 1992) 2 3 4 22 58
  2. Recessive primary congenital lymphoedema caused by a VEGFR3 mutation. (PMID: 19289394) Ghalamkarpour A … Vikkula M (Journal of medical genetics 2009) 3 4 22 58
  3. Autocrine loop between vascular endothelial growth factor (VEGF)-C and VEGF receptor-3 positively regulates tumor-associated lymphangiogenesis in oral squamoid cancer cells. (PMID: 19779139) Matsuura M … Sueishi K (The American journal of pathology 2009) 3 4 22 58
  4. Analysis of the coding regions of VEGFR3 and VEGFC in Milroy disease and other primary lymphoedemas. (PMID: 19002718) Connell FC … Lymphoedema Consortium (Human genetics 2009) 3 22 44 58
  5. A novel VEGFR3 mutation causes Milroy disease. (PMID: 17458866) Butler MG … Glover TW (American journal of medical genetics. Part A 2007) 3 4 22 58

Products for FLT4 Gene

  • Addgene plasmids for FLT4

Sources for FLT4 Gene

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