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Aliases for FLT3LG Gene

Aliases for FLT3LG Gene

  • Fms Related Tyrosine Kinase 3 Ligand 2 3 5
  • Fms-Related Tyrosine Kinase 3 Ligand 2 3
  • Flt3 Ligand 3 4
  • FLT3L 3 4
  • SL Cytokine 4
  • FLG3L 3
  • FL 3

External Ids for FLT3LG Gene

Previous GeneCards Identifiers for FLT3LG Gene

  • GC19P050635
  • GC19P050345
  • GC19P054653
  • GC19P054669
  • GC19P049977
  • GC19P046355

Summaries for FLT3LG Gene

Entrez Gene Summary for FLT3LG Gene

  • Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011]

GeneCards Summary for FLT3LG Gene

FLT3LG (Fms Related Tyrosine Kinase 3 Ligand) is a Protein Coding gene. Diseases associated with FLT3LG include Aplastic Anemia. Among its related pathways are Cytokine Signaling in Immune system and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and cytokine activity.

UniProtKB/Swiss-Prot for FLT3LG Gene

  • Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.

Gene Wiki entry for FLT3LG Gene

Additional gene information for FLT3LG Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLT3LG Gene

Genomics for FLT3LG Gene

GeneHancer (GH) Regulatory Elements for FLT3LG Gene

Promoters and enhancers for FLT3LG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I049472 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.5 470 4.3 PKNOX1 ARID4B SIN3A DMAP1 YBX1 ZNF2 ZBTB7B IRF4 ZNF213 E2F8 ENSG00000273189 FLT3LG ALDH16A1 POLD1 NUP62 RPS11 MED25 PRR12 RPL13A ENSG00000269469
GH19I048871 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE dbSUPER 22 -598.2 -598157 8.8 FEZF1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 MEF2D SSRP1 GC19M048876 PPP1R15A PRR12 SNRNP70 IRF3 GRWD1 SNORD35A PTOV1-AS2 SNORD35B PIH1D1
GH19I049494 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.4 +24.9 24872 9.7 CLOCK FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC MEF2D RPS11 SNORD35B MIR150 GC19P049558 GC19M049503 PRR12 ALDH16A1 SNORD35A IRF3 NUP62
GH19I049486 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 22.8 +16.1 16068 7.5 ZFP64 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC SSRP1 SNORD35A RPL13A GC19P049514 GC19P049531 GC19P049554 GC19P049559 GC19P049561 PIR54526 PIR58998 SNORD32A
GH19I048612 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 19.9 -857.4 -857410 7.8 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 RPL18 FAM83E PIR55128 SPHK2 PRR12 PIH1D1 SNORD35A SNORD35B ALDH16A1 KDELR1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FLT3LG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FLT3LG gene promoter:

Genomic Locations for FLT3LG Gene

Genomic Locations for FLT3LG Gene
chr19:49,474,172-49,486,234
(GRCh38/hg38)
Size:
12,063 bases
Orientation:
Plus strand
chr19:49,977,464-49,989,488
(GRCh37/hg19)

Genomic View for FLT3LG Gene

Genes around FLT3LG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FLT3LG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FLT3LG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FLT3LG Gene

Proteins for FLT3LG Gene

  • Protein details for FLT3LG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49771-FLT3L_HUMAN
    Recommended name:
    Fms-related tyrosine kinase 3 ligand
    Protein Accession:
    P49771
    Secondary Accessions:
    • A0AVC2
    • B9EGH2
    • Q05C96

    Protein attributes for FLT3LG Gene

    Size:
    235 amino acids
    Molecular mass:
    26416 Da
    Quaternary structure:
    • Homodimer (isoform 2).

    Three dimensional structures from OCA and Proteopedia for FLT3LG Gene

    Alternative splice isoforms for FLT3LG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FLT3LG Gene

Post-translational modifications for FLT3LG Gene

  • Glycosylation at posLast=126126 and posLast=149149

Antibody Products

  • R&D Systems Antibodies for FLT3LG (Flt-3 Ligand)
  • Santa Cruz Biotechnology (SCBT) Antibodies for FLT3LG

No data available for DME Specific Peptides for FLT3LG Gene

Domains & Families for FLT3LG Gene

Gene Families for FLT3LG Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FLT3LG Gene

Suggested Antigen Peptide Sequences for FLT3LG Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FLT3LG: view

No data available for UniProtKB/Swiss-Prot for FLT3LG Gene

Function for FLT3LG Gene

Molecular function for FLT3LG Gene

GENATLAS Biochemistry:
FLT3 ligand,stimulating proliferation of hematopoietic cells
UniProtKB/Swiss-Prot Function:
Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.

Phenotypes From GWAS Catalog for FLT3LG Gene

Gene Ontology (GO) - Molecular Function for FLT3LG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 8180375
GO:0005125 cytokine activity IEA --
GO:0030971 receptor tyrosine kinase binding IEA --
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with FLT3LG: view
genes like me logo Genes that share phenotypes with FLT3LG: view

Animal Models for FLT3LG Gene

MGI Knock Outs for FLT3LG:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FLT3LG Gene

Localization for FLT3LG Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLT3LG Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FLT3LG gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 2
nucleus 1
endosome 1

Gene Ontology (GO) - Cellular Components for FLT3LG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IEA --
GO:0016020 membrane NAS,IEA 8145851
genes like me logo Genes that share ontologies with FLT3LG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FLT3LG Gene

Pathways & Interactions for FLT3LG Gene

genes like me logo Genes that share pathways with FLT3LG: view

Interacting Proteins for FLT3LG Gene

SIGNOR curated interactions for FLT3LG Gene

Activates:

Gene Ontology (GO) - Biological Process for FLT3LG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0007165 signal transduction TAS 8180375
GO:0008284 positive regulation of cell proliferation IDA 8180375
GO:0010469 regulation of receptor activity IEA --
GO:0030098 lymphocyte differentiation IEA --
genes like me logo Genes that share ontologies with FLT3LG: view

Drugs & Compounds for FLT3LG Gene

(4) Drugs for FLT3LG Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for FLT3LG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FLT3LG: view

Transcripts for FLT3LG Gene

mRNA/cDNA for FLT3LG Gene

(20) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FLT3LG Gene

Fms-related tyrosine kinase 3 ligand:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FLT3LG Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: - -
SP2: - -
SP3: -

Relevant External Links for FLT3LG Gene

GeneLoc Exon Structure for
FLT3LG
ECgene alternative splicing isoforms for
FLT3LG

Expression for FLT3LG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FLT3LG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FLT3LG Gene

This gene is overexpressed in Whole Blood (x5.9).

NURSA nuclear receptor signaling pathways regulating expression of FLT3LG Gene:

FLT3LG

SOURCE GeneReport for Unigene cluster for FLT3LG Gene:

Hs.428

Evidence on tissue expression from TISSUES for FLT3LG Gene

  • Spleen(4.7)
  • Nervous system(4.2)
  • Lymph node(3.3)
  • Bone marrow(2.8)
  • Blood(2.6)
  • Lung(2)
genes like me logo Genes that share expression patterns with FLT3LG: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FLT3LG Gene

Orthologs for FLT3LG Gene

This gene was present in the common ancestor of chordates.

Orthologs for FLT3LG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FLT3LG 33 34
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia FLT3LG 33 34
  • 85 (n)
cow
(Bos Taurus)
Mammalia FLT3LG 33 34
  • 82.21 (n)
rat
(Rattus norvegicus)
Mammalia LOC102547607 33
  • 74.84 (n)
mouse
(Mus musculus)
Mammalia Flt3l 33 16 34
  • 73.84 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FLT3LG 34
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FLT3LG 34
  • 28 (a)
OneToOne
Species where no ortholog for FLT3LG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FLT3LG Gene

ENSEMBL:
Gene Tree for FLT3LG (if available)
TreeFam:
Gene Tree for FLT3LG (if available)

Paralogs for FLT3LG Gene

(4) SIMAP similar genes for FLT3LG Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with FLT3LG: view

No data available for Paralogs for FLT3LG Gene

Variants for FLT3LG Gene

Sequence variations from dbSNP and Humsavar for FLT3LG Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000017974 -- 49,480,770(+) G/A intron_variant
rs1000555102 -- 49,484,665(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000786769 -- 49,475,127(+) G/A/C intron_variant
rs1000976569 -- 49,481,177(+) G/C intron_variant
rs1001030771 -- 49,486,790(+) A/C 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FLT3LG Gene

Variant ID Type Subtype PubMed ID
esv3644624 CNV gain 21293372
nsv1109203 CNV deletion 24896259
nsv833862 CNV loss 17160897
nsv833863 CNV loss 17160897
nsv953599 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for FLT3LG Gene

Residual Variation Intolerance Score: 57.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FLT3LG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FLT3LG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLT3LG Gene

Disorders for FLT3LG Gene

MalaCards: The human disease database

(1) MalaCards diseases for FLT3LG Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
aplastic anemia
  • aplastic anemia, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FLT3LG

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FLT3LG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FLT3LG Gene

Publications for FLT3LG Gene

  1. Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots. (PMID: 10881197) Savvides SN … Andrew Karplus P (Nature structural biology 2000) 3 4 22 58
  2. Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs. (PMID: 8145851) Hannum C … Mattson J (Nature 1994) 2 3 4 58
  3. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 44 58
  4. Human Flt-3-ligand-mobilized dendritic cells require additional activation to drive effective immune responses. (PMID: 17949888) Diener KR … Hayball JD (Experimental hematology 2008) 3 22 58
  5. Increased blood myeloid dendritic cells and dendritic cell-poietins in Langerhans cell histiocytosis. (PMID: 15728521) Rolland A … Palucka AK (Journal of immunology (Baltimore, Md. : 1950) 2005) 3 22 58

Products for FLT3LG Gene

Sources for FLT3LG Gene

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