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Aliases for FLT3LG Gene

Aliases for FLT3LG Gene

  • Fms Related Tyrosine Kinase 3 Ligand 2 3 5
  • Fms-Related Tyrosine Kinase 3 Ligand 2 3
  • Flt3 Ligand 3 4
  • FLT3L 3 4
  • SL Cytokine 4
  • FL 3

External Ids for FLT3LG Gene

Previous GeneCards Identifiers for FLT3LG Gene

  • GC19P050635
  • GC19P050345
  • GC19P054653
  • GC19P054669
  • GC19P049977
  • GC19P046355

Summaries for FLT3LG Gene

Entrez Gene Summary for FLT3LG Gene

  • Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011]

GeneCards Summary for FLT3LG Gene

FLT3LG (Fms Related Tyrosine Kinase 3 Ligand) is a Protein Coding gene. Diseases associated with FLT3LG include Aplastic Anemia. Among its related pathways are Differentiation Pathway and Innate Immune System. GO annotations related to this gene include protein homodimerization activity and cytokine activity.

UniProtKB/Swiss-Prot for FLT3LG Gene

  • Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.

Gene Wiki entry for FLT3LG Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLT3LG Gene

Genomics for FLT3LG Gene

Regulatory Elements for FLT3LG Gene

Enhancers for FLT3LG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G049494 2 FANTOM5 Ensembl ENCODE dbSUPER 20.4 +24.9 24872 9.7 CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC RPS11 ALDH16A1 SNORD35A PIH1D1 SNORD35B RPL18 FLT3LG PRR12 CD37 POLD1
GH19G048871 1.7 Ensembl ENCODE dbSUPER 22 -598.2 -598158 8.8 CREB3L1 AGO1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 MEF2D FLT3LG PRR12 TULP2 HSD17B14 SNORD35B ALDH16A1 SNORD35A RPS11 PIH1D1 RPL18
GH19G048612 1.7 Ensembl ENCODE dbSUPER 18.6 -857.4 -857410 7.8 CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 SP3 NFYC PRR12 SNORD35A KDELR1 SNORD35B ALDH16A1 GRWD1 SEC1P NOP53-AS1 RPS11 PIH1D1
GH19G049450 1.2 ENCODE 21.7 -21.4 -21361 4.7 MLX CREB3L1 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC TBX21 ZNF610 ALDH16A1 POLD1 SNORD35A SNORD35B NUP62 PIH1D1 FLT3LG PRR12 RPL18 PNKP
GH19G049987 1.2 ENCODE 19.1 +513.1 513127 0.2 MLX CREB3L1 ZFP64 DMAP1 SLC30A9 ZNF143 ZNF263 NFYC TBX21 MEF2D VRK3 PRR12 FLT3LG RRAS NR1H2 ENSG00000268047 ENSG00000221125 ZNF473 CLEC11A TEAD2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FLT3LG on UCSC Golden Path with GeneCards custom track

Promoters for FLT3LG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110902 328 1001 PKNOX1 AGO1 ARID4B SIN3A DMAP1 YBX1 ZNF2 ZBTB7B ZNF207 ZNF143

Genomic Location for FLT3LG Gene

Chromosome:
19
Start:
49,474,172 bp from pter
End:
49,486,234 bp from pter
Size:
12,063 bases
Orientation:
Plus strand

Genomic View for FLT3LG Gene

Genes around FLT3LG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FLT3LG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FLT3LG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FLT3LG Gene

Proteins for FLT3LG Gene

  • Protein details for FLT3LG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49771-FLT3L_HUMAN
    Recommended name:
    Fms-related tyrosine kinase 3 ligand
    Protein Accession:
    P49771
    Secondary Accessions:
    • A0AVC2
    • B9EGH2
    • Q05C96

    Protein attributes for FLT3LG Gene

    Size:
    235 amino acids
    Molecular mass:
    26416 Da
    Quaternary structure:
    • Homodimer (isoform 2).

    Three dimensional structures from OCA and Proteopedia for FLT3LG Gene

    Alternative splice isoforms for FLT3LG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FLT3LG Gene

Post-translational modifications for FLT3LG Gene

  • Glycosylation at Asn126 and Asn149

No data available for DME Specific Peptides for FLT3LG Gene

Domains & Families for FLT3LG Gene

Gene Families for FLT3LG Gene

Protein Domains for FLT3LG Gene

Suggested Antigen Peptide Sequences for FLT3LG Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FLT3LG: view

No data available for UniProtKB/Swiss-Prot for FLT3LG Gene

Function for FLT3LG Gene

Molecular function for FLT3LG Gene

GENATLAS Biochemistry:
FLT3 ligand,stimulating proliferation of hematopoietic cells
UniProtKB/Swiss-Prot Function:
Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.

Gene Ontology (GO) - Molecular Function for FLT3LG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 8180375
GO:0005125 cytokine activity IEA --
GO:0030971 receptor tyrosine kinase binding IEA --
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with FLT3LG: view
genes like me logo Genes that share phenotypes with FLT3LG: view

Animal Models for FLT3LG Gene

MGI Knock Outs for FLT3LG:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FLT3LG Gene

Localization for FLT3LG Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLT3LG Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FLT3LG gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for FLT3LG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA,NAS 8145851
genes like me logo Genes that share ontologies with FLT3LG: view

Pathways & Interactions for FLT3LG Gene

genes like me logo Genes that share pathways with FLT3LG: view

Interacting Proteins for FLT3LG Gene

SIGNOR curated interactions for FLT3LG Gene

Activates:

Gene Ontology (GO) - Biological Process for FLT3LG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0007165 signal transduction TAS 8180375
GO:0008284 positive regulation of cell proliferation IDA 8180375
GO:0030098 lymphocyte differentiation IEA --
GO:0030885 regulation of myeloid dendritic cell activation IEA --
genes like me logo Genes that share ontologies with FLT3LG: view

Drugs & Compounds for FLT3LG Gene

(4) Drugs for FLT3LG Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for FLT3LG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FLT3LG: view

Transcripts for FLT3LG Gene

mRNA/cDNA for FLT3LG Gene

(20) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FLT3LG Gene

Fms-related tyrosine kinase 3 ligand:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FLT3LG Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: - -
SP2: - -
SP3: -

Relevant External Links for FLT3LG Gene

GeneLoc Exon Structure for
FLT3LG
ECgene alternative splicing isoforms for
FLT3LG

Expression for FLT3LG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FLT3LG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FLT3LG Gene

This gene is overexpressed in Whole Blood (x5.9).

NURSA nuclear receptor signaling pathways regulating expression of FLT3LG Gene:

FLT3LG

SOURCE GeneReport for Unigene cluster for FLT3LG Gene:

Hs.428

Evidence on tissue expression from TISSUES for FLT3LG Gene

  • Spleen(4.7)
  • Nervous system(4.2)
  • Lymph node(3.3)
  • Bone marrow(2.8)
  • Blood(2.6)
  • Lung(2)
genes like me logo Genes that share expression patterns with FLT3LG: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FLT3LG Gene

Orthologs for FLT3LG Gene

This gene was present in the common ancestor of chordates.

Orthologs for FLT3LG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FLT3LG 35 34
  • 99.44 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FLT3LG 35 34
  • 85 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FLT3LG 35 34
  • 82.21 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102547607 34
  • 74.84 (n)
mouse
(Mus musculus)
Mammalia Flt3l 35 16 34
  • 73.84 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FLT3LG 35
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FLT3LG 35
  • 28 (a)
OneToOne
Species where no ortholog for FLT3LG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FLT3LG Gene

ENSEMBL:
Gene Tree for FLT3LG (if available)
TreeFam:
Gene Tree for FLT3LG (if available)

Paralogs for FLT3LG Gene

(4) SIMAP similar genes for FLT3LG Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with FLT3LG: view

No data available for Paralogs for FLT3LG Gene

Variants for FLT3LG Gene

Sequence variations from dbSNP and Humsavar for FLT3LG Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000017974 -- 49,480,770(+) CTCAC(A/G)CCTGT intron-variant
rs1000555102 -- 49,484,665(+) CTAAT(G/T)TTTGT intron-variant
rs1000786769 -- 49,475,127(+) CAGGA(A/C/G)GGGGA intron-variant
rs1000976569 -- 49,481,177(+) GATGG(C/G)CAGAG intron-variant
rs1001030771 -- 49,486,790(+) AGATA(A/C)GGCCA upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FLT3LG Gene

Variant ID Type Subtype PubMed ID
esv3644624 CNV gain 21293372
nsv1109203 CNV deletion 24896259
nsv833862 CNV loss 17160897
nsv833863 CNV loss 17160897
nsv953599 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for FLT3LG Gene

Residual Variation Intolerance Score: 57.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FLT3LG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FLT3LG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLT3LG Gene

Disorders for FLT3LG Gene

MalaCards: The human disease database

(1) MalaCards diseases for FLT3LG Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
aplastic anemia
  • pulmonary fibrosis, idiopathic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FLT3LG

Genetic Association Database (GAD)
FLT3LG
Human Genome Epidemiology (HuGE) Navigator
FLT3LG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FLT3LG
genes like me logo Genes that share disorders with FLT3LG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FLT3LG Gene

Publications for FLT3LG Gene

  1. Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots. (PMID: 10881197) Savvides S.N. … Karplus P.A. (Nat. Struct. Biol. 2000) 3 4 22 64
  2. Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs. (PMID: 8145851) Hannum C. … Lee F. (Nature 1994) 2 3 4 64
  3. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty S.E. … . (PLoS Genet. 2010) 3 46 64
  4. Human Flt-3-ligand-mobilized dendritic cells require additional activation to drive effective immune responses. (PMID: 17949888) Diener K.R. … Hayball J.D. (Exp. Hematol. 2008) 3 22 64
  5. Increased blood myeloid dendritic cells and dendritic cell-poietins in Langerhans cell histiocytosis. (PMID: 15728521) Rolland A. … Palucka A.K. (J. Immunol. 2005) 3 22 64

Products for FLT3LG Gene

Sources for FLT3LG Gene

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