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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FLT3LG Gene

protein-coding GIFtS: 62
GCID: GC19P049977

fms-related tyrosine kinase 3 ligand

Explore 36 diseases affiliated with
FLT3LG via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Fms-Related Tyrosine Kinase 3 Ligand¹ ²
Flt3 Ligand² ³
FL²
FLT3L²
Flt3L³
SL Cytokine³

External Ids:	HGNC: 3766¹	Entrez Gene: 2323²	Ensembl: ENSG00000090554⁷	OMIM: 600007⁵	UniProtKB: P49771³

Export aliases for FLT3LG gene to outside databases

Previous GC identifers: GC19P050635 GC19P050345 GC19P054653 GC19P054669 GC19P046355

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FLT3LG:

Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming

pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for

plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue

counterparts (summary by Sathaliyawala et al., 2010 (PubMed 20933441)).(supplied by OMIM, Jan 2011)

UniProtKB/Swiss-Prot: FLT3L_HUMAN, P49771

Function: Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number

of other colony stimulating factors and interleukins

Gene Wiki entry for FLT3LG

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FLT3LG gene promoter:
TBP RelA AP-4 NF-kappaB AP-2gamma c-Ets-1 AP-2beta NF-kappaB1 AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FLT3LG promoter sequence

Search SABiosciences Chromatin IP Primers for FLT3LG

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FLT3LG

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.3

FLT3LG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FLT3LG gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P049977: view genomic region (about GC identifiers)

Start:	49,977,486 bp from pter	End:	49,989,488 bp from pter
Size:	12,003 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FLT3L_HUMAN, P49771 (See protein sequence)

Recommended Name: Fms-related tyrosine kinase 3 ligand precursor

Size: 235 amino acids; 26416 Da

Subunit: Homodimer (isoform 2)

Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein

Subcellular location: Isoform 2: Secreted

3 PDB 3D structures from and Proteopedia for FLT3LG:

1ETE (3D)

3QS7 (3D)

3QS9 (3D)

Secondary accessions: A0AVC2 B9EGH2

Alternative splicing: 2 isoforms: P49771-1 P49771-2

Explore the universe of human proteins at neXtProt for FLT3LG: NX_P49771

FLT3LG Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001191431.1 NP_001191432.1 NP_001450.2

ENSEMBL proteins:

ENSP00000204637 ENSP00000341305

Human Recombinant Protein Products:

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	Uscn Proteins for FLT3LG

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IEA	--
GO:0005625	soluble fraction	--	--
GO:0005886	plasma membrane	IEA	--
GO:0016020	membrane	NAS	8145851
GO:0016021	integral to membrane	NAS	8180375

FLT3LG for ontologies About GeneDecksing

FLT3LG Antibody Products:

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	Uscn ELISAs and CLIAs for FLT3LG

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FLT3LG for domains About GeneDecksing

3 InterPro domains/families:

IPR012351 4_helix_cytokine_core

IPR009079 4_helix_cytokine-like_core

IPR004213 Flt3_lig

Graphical View of Domain Structure for InterPro Entry P49771

ProtoNet protein and cluster: P49771

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FLT3L_HUMAN, P49771

Function: Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number

of other colony stimulating factors and interleukins

Genatlas biochemistry entry for FLT3LG:

FLT3 ligand,stimulating proliferation of hematopoietic cells

Summary:

During embryonic development, FLT3LG as signaling molecule

affects the following cells: B-cell Progenitor Cells in Peripheral Blood

FLT3LG as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Erythroid progenitors, Hematopoietic progenitor cells (see all 11).

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
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		5 QIAGEN miScript miRNA Assays for microRNAs that regulate FLT3LG:
		hsa-miR-379 hsa-miR-3607-3p hsa-miR-493* hsa-let-7g* hsa-let-7a-2*
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for FLT3LG

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLT3LG

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	TAS	8180375
GO:0005125	cytokine activity	IEA	--

FLT3LG for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for FLT3LG:

Synthetic lethal with imatinib

Animal Models:
Mouse knock-out Flt3l^tm1Imx for FLT3LG
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Flt3l):

cellular

hematopoietic system

immune system

FLT3LG for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development FGFR signaling pathway

Development_Flt3 signaling

0.45

Development Flt3 signaling

0.45

Pathways in cancer

Pathways in cancer

1.00

Hematopoietic cell lineage

Hematopoietic cell lineage

1.00

CNTF Signaling

FLT3 Signaling

0.50

PEDF Induced Signaling

Cytokine-cytokine receptor interaction

0.26

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for FLT3LG

Development Flt3 signaling

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for FLT3LG

FLT3 Signaling

1 GeneGo (Thomson Reuters) Pathway for FLT3LG

Development Flt3 signaling

3 Kegg Pathways (Kegg details for FLT3LG):

	Cytokine-cytokine receptor interaction
	Hematopoietic cell lineage
	Pathways in cancer

FLT3LG for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FLT3LG

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for FLT3LG (P49771^{2, 3} ENSP00000204637⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PFN2	P35080²^,³, ENSP00000239940⁴	MINT-63799 I2D: score=4 STRING: ENSP00000239940
KITLG	P21583³, ENSP00000228280⁴	I2D: score=1 STRING: ENSP00000228280
FLT3	P36888³, ENSP00000241453⁴	I2D: score=2 STRING: ENSP00000241453

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	8180375
GO:0008284	positive regulation of cell proliferation	IDA	8180375
GO:0035162	embryonic hemopoiesis	IDA	--

FLT3LG for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FLT3LG for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FLT3LG
7 Novoseek chemical compound relationships for FLT3LG gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pixy321	87.7	8	12881174 (3), 10344557 (1), 12042045 (1), 7544740 (1) (see all 6)
methylcellulose	64	2	9674752 (1), 9216732 (1)
tyrosine	58.4	44	10640965 (1), 12480261 (1), 15749926 (1), 16103070 (1) (see all 40)
rhodamine 123	21.8	2	10084251 (1)
vegf	16.1	3	11276362 (1), 17379761 (1), 11956621 (1)
thymidine	3.42	4	17228266 (1), 19570774 (1), 8916965 (1), 19143470 (1)
cyclophosphamide	0	8	10813543 (1), 11209089 (1)

Search CenterWatch for drugs/clinical trials and news about FLT3LG / FLT3L

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FLT3LG gene (3 alternative transcripts):

NM_001204502.1 NM_001204503.1 NM_001459.3

Unigene Cluster for FLT3LG:

Fms-related tyrosine kinase 3 ligand

Hs.428 [show with all ESTs]

Unigene Representative Sequence: AK301136

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000204637(uc002pnw.3 uc002pnu.3 uc010yau.2 uc002pnv.3 uc002pnx.3 uc010yav.2)

ENST00000344019

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		5 QIAGEN miScript miRNA Assays for microRNAs that regulate FLT3LG:
		hsa-miR-379 hsa-miR-3607-3p hsa-miR-493* hsa-let-7g* hsa-let-7a-2*
		SwitchGear 3'UTR luciferase reporter plasmid: FLT3LG 3' UTR sequence

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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FLT3LG

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Additional cDNA sequence:

AK301136.1 AK308939.1 BC006331.2 BC011914.2 BC028001.1 BC126293.1 BC136464.1 BC144129.1

U03858.1 U04806.1

10 DOTS entries:

DT.86847536 DT.100781762 DT.92417514 DT.95153667 DT.100781764 DT.121505540 DT.75101495 DT.91908448

DT.97790898 DT.100781763

7 AceView cDNA sequences:

BC028001 CR609170 NM_001459 BC006331 BC011914 U03858 U04806

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for FLT3LG About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b
SP1:			-																		-
SP2:			-				-
SP3:							-

ECgene alternative splicing isoforms for FLT3LG

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FLT3LG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATTGTATA

About this image

FLT3LG expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

See FLT3LG Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FLT3LG

SOURCE GeneReport for Unigene cluster: Hs.428

SABiosciences Expression via Pathway-Focused PCR Arrays including FLT3LG:

Antigen Presenting Cells in human mouse rat

Lymphoma in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Hematopoiesis in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLT3LG

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FLT3LG gene from 2/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Flt3l^{1 , 5}	FMS-like tyrosine kinase 3 ligand^{1, 5}	74.74(n)¹ 73.09(a)¹		7 (29.14 cM)⁵ 14256¹ NM_013520.3¹ NP_038548.3¹ 45131188⁵
lizard (Anolis carolinensis)	Reptilia	FLT3LG⁶	--	33(a)	1 ↔ 1	GL343355.1(249104-258326)

ENSEMBL Gene Tree for FLT3LG (if available)
TreeFam Gene Tree for FLT3LG (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs143039986^1,2		--	49975474(+)	`CCTGTA/GATCCC`	2	--	us2k¹		0	--	--	--	--
rs147109222^1,2	C,	--	49975667(+)	`AGAGGC/TTGCAG`	2	--	us2k¹		0	--	--	--	--
rs200484119^1,2		--	49975733(+)	`CAAAG-/AAAAAA`	2	--	us2k¹		0	--	--	--	--
rs190847030^1,2		--	49975803(+)	`GAGGCC/TGAGGT`	2	--	us2k¹		0	--	--	--	--
rs148179712^1,2		--	49975804(+)	`AGGCCA/GAGGTG`	2	--	us2k¹		0	--	--	--	--
rs141941560^1,2		--	49975864(+)	`ATCCCA/GTCTCT`	3	--	us2k¹		0	--	--	--	--
rs12973733^1,2	C,F,	--	49975865(+)	`TCCCGT/ACTCTA`	3	--	us2k¹		8		NA CSA EA	252
rs182606350^1,2		--	49975871(+)	`CTCTAC/TTAAAA`	3	--	us2k¹		0	--	--	--	--
rs188914323^1,2		--	49975978(+)	`GCAGTA/GAGCCA`	3	--	us2k¹		0	--	--	--	--
rs62128074^1,2		--	49976060(+)	`AGGAGT/ACTTCT`	3	--	us2k¹		2		NA	122

HapMap Linkage Disequilibrium report for FLT3LG (49977486 - 49989488 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for FLT3LG
3 CNVs: 5111 5110 32261

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FLT3LG

DNA2.0 Custom Variant and Variant Library Synthesis for FLT3LG

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FLT3LG for disorders           About GeneDecksing

OMIM gene information: 600007    OMIM disorders: --

20/36 diseases for FLT3LG (see all 36):    About MalaCards

langerhans-cell histiocytosis non-hodgkin lymphoma severe combined immunodeficiency stem cell leukemia

herpes simplex combined immunodeficiency systemic lupus erythematosus aplastic anemia

lupus erythematosus hodgkin's lymphoma leukopenia histiocytosis

myelodysplastic syndrome tetanus acute myeloid leukemia allergic asthma

myeloid leukemia autoimmune thyroiditis t-cell leukemia leukemia

10/25 Novoseek disease relationships for FLT3LG gene (see all 25) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glioblastoma multiforme	52.6	1	17522335 (1)
glioma	36.7	7	15564139 (2), 18079358 (2), 16103070 (1), 20375153 (1) (see all 5)
brain tumors	35.1	2	15564139 (1), 18431473 (1)
anemia aplastic	32.1	2	8977241 (1), 9216732 (1)
leukemia	26.7	5	10766177 (2), 10037010 (1), 8977241 (1)
herpes simplex	26.3	6	20375153 (2), 17228266 (1), 18431473 (1), 18079358 (1) (see all 5)
t-all	25.1	1	8641369 (1)
tumors	21.3	39	9270021 (5), 11099317 (2), 10640965 (1), 9834229 (1) (see all 20)
necrosis	19.9	9	10640965 (1), 9834229 (1), 18547160 (1), 12445738 (1) (see all 8)
melanoma	16.8	4	12000870 (1)

Human Genome Epidemiology (HuGE) Navigator: FLT3LG (1 document)

Export disorders for FLT3LG gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for FLT3LG gene, integrated from 9 sources (see all 213):
(articles sorted by number of sources associating them with FLT3LG)

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Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs. (PubMed id 8145851)^{1, 2, 3} Hannum C.... Lee F. (1994)
Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots. (PubMed id 10881197)^{1, 2, 9} Savvides S.N.... Karplus P.A. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification of soluble and membrane-bound isoforms of the murine flt3 ligand generated by alternative splicing of mRNAs. (PubMed id 7824267)^{1, 3} Lyman S.D....Cleveland L.S. (1995)
Structural analysis of human and murine flt3 ligand genomic loci. (PubMed id 7566977)^{1, 2} Lyman S.D....Escobar S. (1995)
Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells. (PubMed id 8180375)^{1, 2} Lyman S.D.... McKenna H.J. (1994)
The membrane-bound isoform of stem cell factor synergizes with soluble flt3 ligand in supporting early hematopoietic cells in long-term cultures of normal and aplastic anemia bone marrow. (PubMed id 9590652)^{1, 9} Slanicka Krieger M....Wodnar-Filipowicz A. (1998)
Flt3 ligand enhances thymic-dependent and thymic-independent immune reconstitution. (PubMed id 15226184)^{1, 9} Fry T.J....Mackall C.L. (2004)
Antiapoptotic cytokine IL-3 + SCF + FLT3L influence on proliferation of gamma-irradiated AC133+/CD34+ progenitor cells. (PubMed id 12002675)^{1, 9} Vavrova J....Filip S. (2002)
Multiple signals are required for maturation of human dendritic cells mobilized in vivo with Flt3 ligand. (PubMed id 12223523)^{1, 9} Mosca P.J....Morse M.A. (2002)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2323	HGNC: 3766	AceView: FLT3LG	Ensembl:ENSG00000090554	euGenes: HUgn2323
ECgene: FLT3LG	Kegg: 2323	H-InvDB: FLT3LG

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for FLT3LG	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for FLT3LG	Genetics and Cytogenetics in Oncology and Haematology

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fms-related tyrosine kinase 3 ligand

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FLT3LG Gene

fms-related tyrosine kinase 3 ligand

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