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FLT3LG Gene

protein-coding   GIFtS: 61
GCID: GC19P049977

Fms-Related Tyrosine Kinase 3 Ligand

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fms-Related Tyrosine Kinase 3 Ligand1 2
Flt3 Ligand2 3
FL2
FLT3L2
Flt3L3
SL Cytokine3

External Ids:    HGNC: 37661   Entrez Gene: 23232   Ensembl: ENSG000000905547   OMIM: 6000075   UniProtKB: P497713   

Export aliases for FLT3LG gene to outside databases

Previous GC identifers: GC19P050635 GC19P050345 GC19P054653 GC19P054669 GC19P046355


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FLT3LG Gene:
Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and
priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important
for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive
tissue counterparts (summary by Sathaliyawala et al., 2010 (PubMed 20933441)).(supplied by OMIM, Jan 2011)

GeneCards Summary for FLT3LG Gene:
FLT3LG (fms-related tyrosine kinase 3 ligand) is a protein-coding gene. Diseases associated with FLT3LG include tetanus, and leukopenia. GO annotations related to this gene include cytokine activity and protein homodimerization activity.

UniProtKB/Swiss-Prot: FLT3L_HUMAN, P49771
Function: Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a
number of other colony stimulating factors and interleukins

Gene Wiki entry for FLT3LG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FLT3LG gene promoter:
         TBP   RelA   AP-4   NF-kappaB   AP-2gamma   c-Ets-1   AP-2beta   NF-kappaB1   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFLT3LG promoter sequence
   Search Chromatin IP Primers for FLT3LG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FLT3LG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

FLT3LG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FLT3LG gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P049977:  view genomic region     (about GC identifiers)

Start:
49,977,464 bp from pter      End:
49,989,488 bp from pter
Size:
12,025 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FLT3L_HUMAN, P49771 (See protein sequence)
Recommended Name: Fms-related tyrosine kinase 3 ligand precursor  
Size: 235 amino acids; 26416 Da
Subunit: Homodimer (isoform 2)
3 PDB 3D structures from and Proteopedia for FLT3LG:
1ETE (3D)        3QS7 (3D)        3QS9 (3D)    
Secondary accessions: A0AVC2 B9EGH2
Alternative splicing: 2 isoforms:  P49771-1   P49771-2   

Explore the universe of human proteins at neXtProt for FLT3LG: NX_P49771

Post-translational modifications: 

  • Glycosylation2 at Asn126, Asn149
  • REFSEQ proteins (5 alternative transcripts): 
    NP_001191431.1  NP_001191432.1  NP_001265566.1  NP_001265567.1  NP_001450.2  

    ENSEMBL proteins: 
     ENSP00000471860   ENSP00000469942   ENSP00000468977   ENSP00000472628   ENSP00000204637  
     ENSP00000470453   ENSP00000469613   ENSP00000471226   ENSP00000469181   ENSP00000473098  
     ENSP00000341305  

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    Sino Biological Recombinant Protein for FLT3LG
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    3 InterPro protein domains:
     IPR012351 4_helix_cytokine_core
     IPR009079 4_helix_cytokine-like_core
     IPR004213 Flt3_lig

    Graphical View of Domain Structure for InterPro Entry P49771

    ProtoNet protein and cluster: P49771


    FLT3LG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FLT3L_HUMAN, P49771
    Function: Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a
    number of other colony stimulating factors and interleukins

         Genatlas biochemistry entry for FLT3LG:
    FLT3 ligand,stimulating proliferation of hematopoietic cells

         Summary: 
    During embryonic development, FLT3LG as signaling molecule affects the following cells:
    Blood: B-cell Progenitor Cells (Peripheral Blood)

    FLT3LG as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
          selected tissues (see all 3)      fully expand
    Blood: ADAtransduced hematopoietic stem cells , Megakaryocytes-like cells      fully expand to see all 6 cells
    Adipose: Brown adipocyte-like cells, Spheres      fully expand to see all 2 cells

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS8180375
    GO:0005125cytokine activity IEA--
    GO:0030971receptor tyrosine kinase binding IEA--
    GO:0042803protein homodimerization activity IEA--
         
    FLT3LG for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FLT3LG:
     Synthetic lethal with imatinib 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Flt3l):
     hematopoietic system  immune system 

    FLT3LG for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Flt3ltm1Imx for FLT3LG

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FLT3LG
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FLT3LG

    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate FLT3LG:
    hsa-miR-379 hsa-miR-3607-3p hsa-miR-493* hsa-let-7g* hsa-let-7a-2*
    SwitchGear 3'UTR luciferase reporter plasmidFLT3LG 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FLT3LG

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): FLT3LG (NM_001204502)
    Sino Biological Human cDNA Clone for FLT3LG
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLT3LG

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FLT3L_HUMAN, P49771: Isoform 1: Cell membrane; Single-pass type I membrane protein
    FLT3L_HUMAN, P49771: Isoform 2: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    cytosol1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0009986cell surface ----
    GO:0016020membrane NAS8145851
    GO:0016021integral component of membrane NAS8180375
    GO:0031233intrinsic component of external side of plasma membrane IEA--

    FLT3LG for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FLT3LG About                                                                                                See pathways by source

    SuperPathContained pathways About
    1CNTF Signaling
    FLT3 Signaling0.50
    2Development FGFR signaling pathway
    Development Flt3 signaling0.45
    3PEDF Induced Signaling
    Cytokine-cytokine receptor interaction0.43
    4Pathways in cancer
    Pathways in cancer
    5Hematopoietic cell lineage
    Hematopoietic cell lineage

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for FLT3LG
        FLT3 Signaling

    1 GeneGo (Thomson Reuters) Pathway for FLT3LG
        Development Flt3 signaling



    3 Kegg Pathways  (Kegg details for FLT3LG):
        Cytokine-cytokine receptor interaction
    Hematopoietic cell lineage
    Pathways in cancer


    FLT3LG for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FLT3LG: 
              Antigen Presenting Cells in human mouse rat
              Lymphoma in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Hematopoiesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FLT3LG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FLT3LG (P497712, 3 ENSP000002046374) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PFN2P350802, 3, ENSP000002399404MINT-63799 I2D: score=4 STRING: ENSP00000239940
    FLT3P368883, ENSP000002414534I2D: score=2 STRING: ENSP00000241453
    KITLGP215833, ENSP000002282804I2D: score=1 STRING: ENSP00000228280
    RPL18ENSP000000847954STRING: ENSP00000084795
    RPL35ENSP000002594694STRING: ENSP00000259469
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS8180375
    GO:0008284positive regulation of cell proliferation IDA8180375
    GO:0030098lymphocyte differentiation IEA--
    GO:0032825positive regulation of natural killer cell differentiation IEA--
    GO:0035162embryonic hemopoiesis IDA--

    FLT3LG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for FLT3LG (see all 12)     About this table
    CompoundAction CAS #
    Amuvatinib (MP-470, HPK 56)Multi-kinase inhibitor, inhibits PDGFR, c-Kit, and Flt3[850879-09-3]
    AST 487high selectivity and potency toward FLT3[630124-46-8]
    Cabozantinib (XL184, BMS-907351)Multi-target kinase inhibitor, inhibits c-Met, VEGFR2, and RET[849217-68-1]
    KW 2449multiple-targeted inhibitor, mostly for Flt3[1000669-72-6]
    LestaurtinibPotent JAK2, FLT3 and TrkA inhibitor[111358-88-4]
    Linifanib (ABT-869)ATP-competitive, multi-targeted RTK inhibitor[796967-16-3]
    Ponatinib (AP24534)pan-BCR-ABL inhibitor[943319-70-8]
    Quizartinib (AC220)Potent and selective FLT3 inhibitor[950769-58-1]
    SB1317inhibits CDKs 1, 2, 7 and 9 together with JAK2 and FLT3[937270-47-8]
    SU5416VEGF receptor inhibitor and an aryl hydrocarbon receptor (AHR) agonist[204005-46-9]

    Browse Tocris compounds for FLT3LG (FLT3L)

    7 Novoseek inferred chemical compound relationships for FLT3LG gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pixy321 87.7 8 12881174 (3), 10344557 (1), 12042045 (1), 7544740 (1) (see all 6)
    methylcellulose 64 2 9674752 (1), 9216732 (1)
    tyrosine 58.4 44 10640965 (1), 12480261 (1), 15749926 (1), 16103070 (1) (see all 40)
    rhodamine 123 21.8 2 10084251 (1)
    vegf 16.1 3 11276362 (1), 17379761 (1), 11956621 (1)
    thymidine 3.42 4 17228266 (1), 19570774 (1), 8916965 (1), 19143470 (1)
    cyclophosphamide 0 8 10813543 (1), 11209089 (1)



    FLT3LG for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FLT3LG gene (5 alternative transcripts): 
    NM_001204502.1  NM_001204503.1  NM_001278637.1  NM_001278638.1  NM_001459.3  

    Unigene Cluster for FLT3LG:

    Fms-related tyrosine kinase 3 ligand
    Hs.428  [show with all ESTs]
    Unigene Representative Sequence: AK301136
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000601800 ENST00000596435 ENST00000597551 ENST00000600084 ENST00000204637(uc002pnw.3 uc002pnu.3 uc010yau.2 uc002pnv.3 uc002pnx.3 uc010yav.2)
    ENST00000600429 ENST00000594009 ENST00000593422 ENST00000595510 ENST00000598555
    ENST00000598472 ENST00000597914 ENST00000344019
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    SwitchGear 3'UTR luciferase reporter plasmidFLT3LG 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat FLT3LG
      QuantiFast Probe-based Assays in human, mouse, rat FLT3LG

    Additional mRNA sequence: 

    AK301136.1 AK308939.1 BC006331.2 BC011914.2 BC028001.1 BC126293.1 BC136464.1 BC144129.1 
    U03858.1 U04806.1 

    10 DOTS entries:

    DT.86847536  DT.100781762  DT.92417514  DT.95153667  DT.100781764  DT.121505540  DT.75101495  DT.91908448 
    DT.97790898  DT.100781763 

    7 AceView cDNA sequences:

    BC006331 NM_001459 CR609170 BC028001 BC011914 U03858 U04806 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FLT3LG    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:        -                                                     -         
    SP2:        -           -                                                   
    SP3:                    -                                                   


    ECgene alternative splicing isoforms for FLT3LG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FLT3LG expression in normal human tissues (normalized intensities)      FLT3LG embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTGTATA
    FLT3LG Expression
    About this image


    FLT3LG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Eye (Sensory Organs)
    FLT3LG Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.428
        Pathway & Disease-focused RT2 Profiler PCR Arrays including FLT3LG: 
              Antigen Presenting Cells in human mouse rat
              Lymphoma in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Hematopoiesis in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat FLT3LG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLT3LG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FLT3LG gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Flt3l1 , 5 FMS-like tyrosine kinase 3 ligand1, 5 73.84(n)1
    72.2(a)1
      7 (29.14 cM)5
    142561  NM_013520.31  NP_038548.31 
     451311885 
    lizard
    (Anolis carolinensis)
    Reptilia FLT3LG6
    fms-related tyrosine kinase 3 ligand
    28(a)
    1 ↔ 1
    GL343355.1(247326-272132)


    ENSEMBL Gene Tree for FLT3LG (if available)
    TreeFam Gene Tree for FLT3LG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FLT3LG gene
    4 SIMAP similar genes for FLT3LG using alignment to 7 protein entries:     FLT3L_HUMAN (see all proteins):
    BIRC5    DKFZp666K083    OK/SW-cl.18    PFKM

    FLT3LG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FLT3LG (see all 311)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1430399861,2
    C--49975474(+) CCTGTA/GATCCC 2 -- us2k10--------
    rs1471092221,2
    C--49975667(+) AGAGGC/TTGCAG 2 -- us2k10--------
    rs2004841191,2
    --49975733(+) CAAAG-/AAAAAA 2 -- us2k10--------
    rs1908470301,2
    --49975803(+) GAGGCC/TGAGGT 2 -- us2k10--------
    rs1481797121,2
    --49975804(+) AGGCCA/GAGGTG 2 -- us2k10--------
    rs1419415601,2
    C--49975864(+) ATCCCA/GTCTCT 3 -- us2k10--------
    rs129737331,2
    C,F--49975865(+) TCCCGT/ACTCTA 3 -- us2k18Minor allele frequency- A:0.28NA CSA EA 252
    rs1826063501,2
    --49975871(+) CTCTAC/TTAAAA 3 -- us2k10--------
    rs1889143231,2
    --49975978(+) GCAGTA/GAGCCA 3 -- us2k10--------
    rs621280741,2
    F--49976060(+) AGGAGT/ACTTCT 3 -- us2k12Minor allele frequency- A:0.02NA 122

    HapMap Linkage Disequilibrium report for FLT3LG (49977464 - 49989488 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for FLT3LG:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833862CNV Loss17160897
    nsv912262CNV Loss21882294
    nsv912264CNV Loss21882294
    nsv833863CNV Loss17160897
    nsv912261CNV Loss21882294
    nsv912265CNV Loss21882294
    nsv9739CNV Gain+Loss18304495

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600007    OMIM disorders: --

    Selected diseases for FLT3LG (see all 35):    About MalaCards
    tetanus    leukopenia    aplastic anemia    vaccinia
    langerhans-cell histiocytosis    burns    histiocytosis    non-hodgkin lymphoma
    allergic asthma    glioblastoma multiforme    herpes simplex    myelodysplastic syndromes
    thrombocytopenia    hodgkin's lymphoma    acute leukemia    severe combined immunodeficiency
    autoimmune thyroiditis    papilloma    encephalomyelitis    peritonitis


    FLT3LG for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for FLT3LG gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioblastoma multiforme 52.6 1 17522335 (1)
    glioma 36.7 7 15564139 (2), 18079358 (2), 16103070 (1), 20375153 (1) (see all 5)
    brain tumors 35.1 2 15564139 (1), 18431473 (1)
    anemia aplastic 32.1 2 8977241 (1), 9216732 (1)
    leukemia 26.7 5 10766177 (2), 10037010 (1), 8977241 (1)
    herpes simplex 26.3 6 20375153 (2), 17228266 (1), 18431473 (1), 18079358 (1) (see all 5)
    t-all 25.1 1 8641369 (1)
    tumors 21.3 39 9270021 (5), 11099317 (2), 10640965 (1), 9834229 (1) (see all 20)
    necrosis 19.9 9 10640965 (1), 9834229 (1), 18547160 (1), 12445738 (1) (see all 8)
    melanoma 16.8 4 12000870 (1)

    Genetic Association Database (GAD): FLT3LG
    Human Genome Epidemiology (HuGE) Navigator: FLT3LG (1 document)

    Export disorders for FLT3LG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FLT3LG gene, integrated from 10 sources (see all 214):
    (articles sorted by number of sources associating them with FLT3LG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs. (PubMed id 8145851)1, 2, 3 Hannum C.... Lee F. (Nature 1994)
    2. Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots. (PubMed id 10881197)1, 2, 9 Savvides S.N.... Karplus P.A. (Nat. Struct. Biol. 2000)
    3. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Identification of soluble and membrane-bound isoforms of the murine flt3 ligand generated by alternative splicing of mRNAs. (PubMed id 7824267)1, 3 Lyman S.D....Cleveland L.S. (Oncogene 1995)
    6. Structural analysis of human and murine flt3 ligand genomic loci. (PubMed id 7566977)1, 2 Lyman S.D....Escobar S. (Oncogene 1995)
    7. Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells. (PubMed id 8180375)1, 2 Lyman S.D.... McKenna H.J. (Blood 1994)
    8. The membrane-bound isoform of stem cell factor synergizes with soluble flt3 ligand in supporting early hematopoietic cells in long-term cultures of normal and aplastic anemia bone marrow. (PubMed id 9590652)1, 9 Slanicka Krieger M....Wodnar-Filipowicz A. (Exp. Hematol. 1998)
    9. Flt3 ligand enhances thymic-dependent and thymic-independent immune reconstitution. (PubMed id 15226184)1, 9 Fry T.J....Mackall C.L. (Blood 2004)
    10. Antiapoptotic cytokine IL-3 + SCF + FLT3L influence on proliferation of gamma-irradiated AC133+/CD34+ progenitor cells. (PubMed id 12002675)1, 9 VA!vrovA! J....Filip S. (Folia Biol. (Praha) 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2323 HGNC: 3766 AceView: FLT3LG Ensembl:ENSG00000090554 euGenes: HUgn2323
    ECgene: FLT3LG Kegg: 2323 H-InvDB: FLT3LG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FLT3LG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FLT3LG Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FLT3LG gene:
    Search GeneIP for patents involving FLT3LG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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