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Aliases for FLT3LG Gene

Aliases for FLT3LG Gene

  • Fms-Related Tyrosine Kinase 3 Ligand 2 3
  • Flt3 Ligand 3 4
  • FLT3L 3 4
  • SL Cytokine 4
  • FL 3

External Ids for FLT3LG Gene

Previous GeneCards Identifiers for FLT3LG Gene

  • GC19P050635
  • GC19P050345
  • GC19P054653
  • GC19P054669
  • GC19P049977
  • GC19P046355

Summaries for FLT3LG Gene

Entrez Gene Summary for FLT3LG Gene

  • Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011]

GeneCards Summary for FLT3LG Gene

FLT3LG (Fms-Related Tyrosine Kinase 3 Ligand) is a Protein Coding gene. Diseases associated with FLT3LG include vaccinia and aplastic anemia. Among its related pathways are Pathways in cancer and CNTF Signaling. GO annotations related to this gene include protein homodimerization activity and cytokine activity.

UniProtKB/Swiss-Prot for FLT3LG Gene

  • Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins

Gene Wiki entry for FLT3LG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLT3LG Gene

Genomics for FLT3LG Gene

Regulatory Elements for FLT3LG Gene

Genomic Location for FLT3LG Gene

Start:
49,474,201 bp from pter
End:
49,486,234 bp from pter
Size:
12,034 bases
Orientation:
Plus strand

Genomic View for FLT3LG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FLT3LG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FLT3LG Gene

Proteins for FLT3LG Gene

  • Protein details for FLT3LG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49771-FLT3L_HUMAN
    Recommended name:
    Fms-related tyrosine kinase 3 ligand
    Protein Accession:
    P49771
    Secondary Accessions:
    • A0AVC2
    • B9EGH2
    • Q05C96

    Protein attributes for FLT3LG Gene

    Size:
    235 amino acids
    Molecular mass:
    26416 Da
    Quaternary structure:
    • Homodimer (isoform 2)

    Three dimensional structures from OCA and Proteopedia for FLT3LG Gene

    Alternative splice isoforms for FLT3LG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FLT3LG Gene

Proteomics data for FLT3LG Gene at MOPED

Post-translational modifications for FLT3LG Gene

  • Glycosylation at Asn126 and Asn149

No data available for DME Specific Peptides for FLT3LG Gene

Domains for FLT3LG Gene

Gene Families for FLT3LG Gene

HGNC:

Protein Domains for FLT3LG Gene

Suggested Antigen Peptide Sequences for FLT3LG Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FLT3LG: view

No data available for UniProtKB/Swiss-Prot for FLT3LG Gene

Function for FLT3LG Gene

Molecular function for FLT3LG Gene

GENATLAS Biochemistry: FLT3 ligand,stimulating proliferation of hematopoietic cells
UniProtKB/Swiss-Prot Function: Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins

LifeMap Function Summary for FLT3LG Gene

Gene Ontology (GO) - Molecular Function for FLT3LG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 8180375
GO:0005125 cytokine activity IEA --
GO:0030971 receptor tyrosine kinase binding IEA --
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with FLT3LG: view

Phenotypes for FLT3LG Gene

MGI mutant phenotypes for FLT3LG:
inferred from 1 alleles
GenomeRNAi human phenotypes for FLT3LG:
genes like me logo Genes that share phenotypes with FLT3LG: view

Animal Models for FLT3LG Gene

MGI Knock Outs for FLT3LG:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for FLT3LG Gene

Localization for FLT3LG Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLT3LG Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FLT3LG Gene COMPARTMENTS Subcellular localization image for FLT3LG gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 1

Gene Ontology (GO) - Cellular Components for FLT3LG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0009986 cell surface --
GO:0016020 membrane NAS 8145851
GO:0016021 integral component of membrane NAS 8180375
GO:0031233 intrinsic component of external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with FLT3LG: view

Pathways for FLT3LG Gene

genes like me logo Genes that share pathways with FLT3LG: view

Pathways by source for FLT3LG Gene

1 Qiagen pathway for FLT3LG Gene
1 GeneGo (Thomson Reuters) pathway for FLT3LG Gene

Interacting Proteins for FLT3LG Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000468977%0d%0a9606.ENSP00000241453%0d%0a9606.ENSP00000228280%0d%0a
Selected Interacting proteins: P49771-FLT3L_HUMAN ENSP00000468977 for FLT3LG Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for FLT3LG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0007165 signal transduction TAS 8180375
GO:0008284 positive regulation of cell proliferation IDA 8180375
GO:0030098 lymphocyte differentiation IEA --
GO:0030885 regulation of myeloid dendritic cell activation IEA --
genes like me logo Genes that share ontologies with FLT3LG: view

Compounds for FLT3LG Gene

(12) ApexBio Compounds for FLT3LG Gene

Compound Action Cas Number
Amuvatinib (MP-470, HPK 56) Multi-kinase inhibitor, inhibits PDGFR, c-Kit, and Flt3 [850879-09-3]
AST 487 high selectivity and potency toward FLT3 [630124-46-8]
Cabozantinib (XL184, BMS-907351) Multi-target kinase inhibitor, inhibits c-Met, VEGFR2, and RET [849217-68-1]
KW 2449 multiple-targeted inhibitor, mostly for Flt3. [1000669-72-6]
Lestaurtinib Potent JAK2, FLT3 and TrkA inhibitor. [111358-88-4]
Linifanib (ABT-869) ATP-competitive, multi-targeted RTK inhibitor [796967-16-3]
Ponatinib (AP24534) pan-BCR-ABL inhibitor [943319-70-8]
Quizartinib (AC220) Potent and selective FLT3 inhibitor [950769-58-1]
SB1317 novel pyrimidine-based multi-kinase inhibitor that inhibits CDKs 1, 2, 7 and 9 together with JAK2 and FLT3 [937270-47-8]
SU5416 VEGF receptor inhibitor and an aryl hydrocarbon receptor (AHR) agonist [204005-46-9]
TCS 359 Potent inhibitor of FLT3 receptor tyrosine kinase [301305-73-7]
TG101209 JAK2 and 3 inhibitor, also inhibits Flt3 and RET [936091-14-4]

(7) Novoseek inferred chemical compound relationships for FLT3LG Gene

Compound -log(P) Hits PubMed IDs
pixy321 87.7 8
methylcellulose 64 2
tyrosine 58.4 40
rhodamine 123 21.8 1
vegf 16.1 3
genes like me logo Genes that share compounds with FLT3LG: view

Transcripts for FLT3LG Gene

mRNA/cDNA for FLT3LG Gene

(7) Selected AceView cDNA sequences:
(22) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FLT3LG Gene

Fms-related tyrosine kinase 3 ligand:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FLT3LG Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: - -
SP2: - -
SP3: -

Relevant External Links for FLT3LG Gene

GeneLoc Exon Structure for
FLT3LG
ECgene alternative splicing isoforms for
FLT3LG

Expression for FLT3LG Gene

mRNA expression in normal human tissues for FLT3LG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FLT3LG Gene

This gene is overexpressed in Whole Blood (5.9).

SOURCE GeneReport for Unigene cluster for FLT3LG Gene Hs.428

genes like me logo Genes that share expressions with FLT3LG: view

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for FLT3LG Gene

Orthologs for FLT3LG Gene

This gene was present in the common ancestor of chordates.

Orthologs for FLT3LG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FLT3LG 35
  • 99.44 (n)
  • 99.44 (a)
FLT3LG 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FLT3LG 35
  • 82.21 (n)
  • 79.78 (a)
FLT3LG 36
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FLT3LG 35
  • 85 (n)
  • 80.91 (a)
FLT3LG 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Flt3l 35
  • 73.84 (n)
  • 72.2 (a)
Flt3l 16
Flt3l 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FLT3LG 36
  • 40 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102547607 35
  • 74.84 (n)
  • 71.63 (a)
lizard
(Anolis carolinensis)
Reptilia FLT3LG 36
  • 28 (a)
OneToOne
Species with no ortholog for FLT3LG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FLT3LG Gene

ENSEMBL:
Gene Tree for FLT3LG (if available)
TreeFam:
Gene Tree for FLT3LG (if available)

Paralogs for FLT3LG Gene

Selected SIMAP similar genes for FLT3LG Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with FLT3LG: view

No data available for Paralogs for FLT3LG Gene

Variants for FLT3LG Gene

Sequence variations from dbSNP and Humsavar for FLT3LG Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1042120 -- 49,480,416(+) CTGGC(C/T)GCTGC reference, synonymous-codon, missense
rs2946846 -- 49,481,936(+) GATCC(A/G)CCCGC intron-variant, downstream-variant-500B
rs2946871 -- 49,474,201(+) TGTCT(C/G)CCCCC upstream-variant-2KB, utr-variant-5-prime
rs3745307 -- 49,476,314(-) ggctg(A/G)ggact intron-variant
rs3826717 -- 49,476,636(-) CCTAG(C/T)GGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FLT3LG Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv912261 CNV Loss 21882294
nsv912262 CNV Loss 21882294
nsv912264 CNV Loss 21882294
nsv833862 CNV Loss 17160897
nsv912265 CNV Loss 21882294
nsv833863 CNV Loss 17160897

Relevant External Links for FLT3LG Gene

HapMap Linkage Disequilibrium report
FLT3LG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLT3LG Gene

Disorders for FLT3LG Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for FLT3LG Gene including...

Search for FLT3LG Gene in MalaCards »

(25) Novoseek inferred disease relationships for FLT3LG Gene

Disease -log(P) Hits PubMed IDs
glioblastoma multiforme 52.6 1
glioma 36.7 7
brain tumors 35.1 2
anemia aplastic 32.1 2
leukemia 26.7 4

Relevant External Links for FLT3LG

Genetic Association Database (GAD)
FLT3LG
Human Genome Epidemiology (HuGE) Navigator
FLT3LG
genes like me logo Genes that share disorders with FLT3LG: view

No data available for UniProtKB/Swiss-Prot for FLT3LG Gene

Publications for FLT3LG Gene

  1. Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots. (PMID: 10881197) Savvides S.N. … Karplus P.A. (Nat. Struct. Biol. 2000) 3 4 23
  2. Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs. (PMID: 8145851) Hannum C. … Lee F. (Nature 1994) 2 3 4
  3. Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells. (PMID: 8180375) Lyman S.D. … McKenna H.J. (Blood 1994) 3 4
  4. Antiapoptotic cytokine IL-3 + SCF + FLT3L influence on proliferation of gamma-irradiated AC133+/CD34+ progenitor cells. (PMID: 12002675) VA!vrovA! J. … Filip S. (Folia Biol. (Praha) 2002) 3 23
  5. Interleukin 8 and Flt3 ligand as markers of advanced disease in primary gastrointestinal non-Hodgkin's lymphoma. (PMID: 11956621) Retzlaff S. … Berdel W.E. (Oncol. Rep. 2002) 3 23

Products for FLT3LG Gene

Sources for FLT3LG Gene

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