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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FLT3LG Gene

protein-coding   GIFtS: 61
GCID: GC19P049977

Fms-Related Tyrosine Kinase 3 Ligand

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fms-Related Tyrosine Kinase 3 Ligand1 2
Flt3 Ligand2 3
FL2
FLT3L2
Flt3L3
SL Cytokine3

External Ids:    HGNC: 37661   Entrez Gene: 23232   Ensembl: ENSG000000905547   OMIM: 6000075   UniProtKB: P497713   

Export aliases for FLT3LG gene to outside databases

Previous GC identifers: GC19P050635 GC19P050345 GC19P054653 GC19P054669 GC19P046355


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FLT3LG Gene:
Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and
priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important
for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive
tissue counterparts (summary by Sathaliyawala et al., 2010 (PubMed 20933441)).(supplied by OMIM, Jan 2011)

GeneCards Summary for FLT3LG Gene: 
FLT3LG (fms-related tyrosine kinase 3 ligand) is a protein-coding gene. Diseases associated with FLT3LG include stem cell leukemia, and tetanus, and among its related super-pathways are CNTF Signaling and Development FGFR signaling pathway. GO annotations related to this gene include cytokine activity and receptor binding.

UniProtKB/Swiss-Prot: FLT3L_HUMAN, P49771
Function: Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a
number of other colony stimulating factors and interleukins

Gene Wiki entry for FLT3LG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FLT3LG gene promoter:
         TBP   RelA   AP-4   NF-kappaB   AP-2gamma   c-Ets-1   AP-2beta   NF-kappaB1   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFLT3LG promoter sequence
   Search SABiosciences Chromatin IP Primers for FLT3LG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FLT3LG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

FLT3LG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FLT3LG gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P049977:  view genomic region     (about GC identifiers)

Start:
49,977,464 bp from pter      End:
49,990,894 bp from pter
Size:
13,431 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FLT3L_HUMAN, P49771 (See protein sequence)
Recommended Name: Fms-related tyrosine kinase 3 ligand precursor  
Size: 235 amino acids; 26416 Da
Subunit: Homodimer (isoform 2)
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Secreted
3 PDB 3D structures from and Proteopedia for FLT3LG:
1ETE (3D)        3QS7 (3D)        3QS9 (3D)    
Secondary accessions: A0AVC2 B9EGH2
Alternative splicing: 2 isoforms:  P49771-1   P49771-2   

Explore the universe of human proteins at neXtProt for FLT3LG: NX_P49771

Explore proteomics data for FLT3LG at MOPED 

FLT3LG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

FLT3LG Protein Expression

REFSEQ proteins (5 alternative transcripts): 
NP_001191431.1  NP_001191432.1  NP_001265566.1  NP_001265567.1  NP_001450.2  

ENSEMBL proteins: 
 ENSP00000471860   ENSP00000469942   ENSP00000468977   ENSP00000472628   ENSP00000204637  
 ENSP00000470453   ENSP00000469613   ENSP00000471226   ENSP00000469181   ENSP00000473098  
 ENSP00000341305  

Human Recombinant Protein Products for FLT3LG: 
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OriGene Purified Protein for FLT3LG
OriGene Protein Over-expression Lysate for FLT3LG
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GenScript Purified and Recombinant Proteins for FLT3LG
Novus Biologicals FLT3LG Proteins
Novus Biologicals FLT3LG Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
ProSpec Recombinant Protein for FLT3LG
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space IEA--
GO:0005886plasma membrane ----
GO:0009986cell surface ----
GO:0016020membrane NAS8145851
GO:0016021integral to membrane NAS8180375

FLT3LG for ontologies           About GeneDecksing



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Abcam antibodies for FLT3LG
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Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
3 InterPro protein domains:
 IPR012351 4_helix_cytokine_core
 IPR009079 4_helix_cytokine-like_core
 IPR004213 Flt3_lig

Graphical View of Domain Structure for InterPro Entry P49771

ProtoNet protein and cluster: P49771


FLT3LG for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: FLT3L_HUMAN, P49771
Function: Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a
number of other colony stimulating factors and interleukins

     Genatlas biochemistry entry for FLT3LG:
FLT3 ligand,stimulating proliferation of hematopoietic cells

     Summary:
During embryonic development, FLT3LG as signaling molecule
affects the following cells: B-cell Progenitor Cells in Peripheral Blood

FLT3LG as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Hematopoietic progenitor cells from Blood, Embryoid bodies from Primitive Streak (see all).

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005102receptor binding TAS8180375
GO:0005125cytokine activity IEA--
GO:0030971receptor tyrosine kinase binding IEA--
GO:0042803protein homodimerization activity IEA--
     
FLT3LG for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for FLT3LG:
 Synthetic lethal with imatinib 

     3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Flt3l):
 cellular  hematopoietic system  immune system 

FLT3LG for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Flt3ltm1Imx for FLT3LG

   inGenious Targeting Laboratory - Custom generated mouse model solutions for FLT3LG 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FLT3LG

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FLT3LG 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FLT3LG 

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FLT3LG
5 QIAGEN miScript miRNA Assays for microRNAs that regulate FLT3LG:
hsa-miR-379 hsa-miR-3607-3p hsa-miR-493* hsa-let-7g* hsa-let-7a-2*
SwitchGear 3'UTR luciferase reporter plasmidFLT3LG 3' UTR sequence
Inhib. RNA
Products:
    
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OriGene RNAi products in human, mouse, rat for FLT3LG
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FLT3LG

Gene Editing
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Sirion Biotech Customized adenovirus for overexpression of FLT3LG

Clone
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GenScript: all cDNA clones in your preferred vector (see all 3): FLT3LG (NM_001204502)
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                     Customized lentivirus expression plasmids for stable overexpression of FLT3LG 

Cell Line
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Search LifeMap BioReagents cell lines for FLT3LG
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLT3LG


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for FLT3LG About                                                                                                See pathways by source

SuperPathContained pathways About
1CNTF Signaling
FLT3 Signaling0.50
2Development FGF-family signaling
Development Flt3 signaling0.45
3PEDF Induced Signaling
Cytokine-cytokine receptor interaction0.43
4Pathways in cancer
Pathways in cancer
5Hematopoietic cell lineage
Hematopoietic cell lineage

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for FLT3LG
    Development Flt3 signaling

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for FLT3LG
    FLT3 Signaling

1 GeneGo (Thomson Reuters) Pathway for FLT3LG
    Development Flt3 signaling


3         Kegg Pathways  (Kegg details for FLT3LG):
    Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
Pathways in cancer


FLT3LG for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FLT3LG

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for FLT3LG (P497712, 3 ENSP000002046374) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
PFN2P350802, 3, ENSP000002399404MINT-63799 I2D: score=4 STRING: ENSP00000239940
KITLGP215833, ENSP000002282804I2D: score=1 STRING: ENSP00000228280
FLT3P368883, ENSP000002414534I2D: score=2 STRING: ENSP00000241453
About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007165signal transduction TAS8180375
GO:0008284positive regulation of cell proliferation IDA8180375
GO:0030098lymphocyte differentiation IEA--
GO:0032825positive regulation of natural killer cell differentiation IEA--
GO:0035162embryonic hemopoiesis IDA--

FLT3LG for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FLT3LG for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FLT3LG (FLT3L)

7 Novoseek inferred chemical compound relationships for FLT3LG gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
pixy321 87.7 8 12881174 (3), 10344557 (1), 12042045 (1), 7544740 (1) (see all 6)
methylcellulose 64 2 9674752 (1), 9216732 (1)
tyrosine 58.4 44 10640965 (1), 12480261 (1), 15749926 (1), 16103070 (1) (see all 40)
rhodamine 123 21.8 2 10084251 (1)
vegf 16.1 3 11276362 (1), 17379761 (1), 11956621 (1)
thymidine 3.42 4 17228266 (1), 19570774 (1), 8916965 (1), 19143470 (1)
cyclophosphamide 0 8 10813543 (1), 11209089 (1)

Search CenterWatch for drugs/clinical trials and news about FLT3LG / FLT3L

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FLT3LG gene (5 alternative transcripts): 
NM_001204502.1  NM_001204503.1  NM_001278637.1  NM_001278638.1  NM_001459.3  

Unigene Cluster for FLT3LG:

Fms-related tyrosine kinase 3 ligand
Hs.428  [show with all ESTs]
Unigene Representative Sequence: AK301136
14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000601800 ENST00000596435 ENST00000597551 ENST00000600084 ENST00000204637(uc002pnw.3 uc002pnu.3 uc010yau.2 uc002pnv.3 uc002pnx.3 uc010yav.2)
ENST00000600429 ENST00000594009 ENST00000593422 ENST00000595815 ENST00000595510
ENST00000598555 ENST00000598472 ENST00000597914 ENST00000344019
miRNA
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5 QIAGEN miScript miRNA Assays for microRNAs that regulate FLT3LG:
hsa-miR-379 hsa-miR-3607-3p hsa-miR-493* hsa-let-7g* hsa-let-7a-2*
SwitchGear 3'UTR luciferase reporter plasmidFLT3LG 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
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QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FLT3LG
Clone
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OriGene ORF clones in mouse, rat for FLT3LG
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): FLT3LG (NM_001204502)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for FLT3LG
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLT3LG
Sirion Biotech Customized lentivirus for stable overexpression of FLT3LG 
                     Customized lentivirus expression plasmids for stable overexpression of FLT3LG 
Primer
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OriGene qPCR primer pairs and template standards for FLT3LG
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FLT3LG
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FLT3LG

Additional mRNA sequence: 

AK301136.1 AK308939.1 BC006331.2 BC011914.2 BC028001.1 BC126293.1 BC136464.1 BC144129.1 
U03858.1 U04806.1 

10 DOTS entries:

DT.86847536  DT.100781762  DT.92417514  DT.95153667  DT.100781764  DT.121505540  DT.75101495  DT.91908448 
DT.97790898  DT.100781763 

7 AceView cDNA sequences:

NM_001459 BC028001 BC011914 CR609170 BC006331 U03858 U04806 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for FLT3LG    About this scheme

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1:        -                                                     -         
SP2:        -           -                                                   
SP3:                    -                                                   


ECgene alternative splicing isoforms for FLT3LG

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FLT3LG expression in normal human tissues (normalized intensities)      FLT3LG embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAATTGTATA
FLT3LG Expression
About this image


FLT3LG expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/3 selected tissues (see all 3) fully expand
 
 Blood (Cardiovascular System)    fully expand to see all 5 entries
         T Helper Cells Thymus
         lymphocytes   
 
 Thymus (Hematopoietic System)    fully expand to see all 2 entries
         T Helper Cells Thymus
 
 Eye (Sensory Organs)

See FLT3LG Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FLT3LG

SOURCE GeneReport for Unigene cluster: Hs.428
    SABiosciences Expression via Pathway-Focused PCR Arrays including FLT3LG: 
          Antigen Presenting Cells in human mouse rat
          Lymphoma in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat
          Hematopoiesis in human mouse rat

Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for FLT3LG
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QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FLT3LG
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FLT3LG
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLT3LG

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FLT3LG gene from 2/7 species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Flt3l1 , 5 FMS-like tyrosine kinase 3 ligand1, 5 74.74(n)1
73.09(a)1
  7 (29.14 cM)5
142561  NM_013520.31  NP_038548.31 
 451311885 
lizard
(Anolis carolinensis)
Reptilia FLT3LG6
fms-related tyrosine kinase 3 ligand
26(a)
1 ↔ 1
GL343355.1(247326-272132)


ENSEMBL Gene Tree for FLT3LG (if available)
TreeFam Gene Tree for FLT3LG (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for FLT3LG gene
4 SIMAP similar genes for FLT3LG using alignment to 7 protein entries:     FLT3L_HUMAN (see all proteins):
BIRC5    DKFZp666K083    OK/SW-cl.18    PFKM

FLT3LG for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/311 SNPs in FLT3LG are shown (see all 311)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1430399861,2
C--49975474(+) CCTGTA/GATCCC 2 -- us2k10--------
rs1471092221,2
C--49975667(+) AGAGGC/TTGCAG 2 -- us2k10--------
rs2004841191,2
--49975733(+) CAAAG-/AAAAAA 2 -- us2k10--------
rs1908470301,2
--49975803(+) GAGGCC/TGAGGT 2 -- us2k10--------
rs1481797121,2
--49975804(+) AGGCCA/GAGGTG 2 -- us2k10--------
rs1419415601,2
C--49975864(+) ATCCCA/GTCTCT 3 -- us2k10--------
rs129737331,2
C,F--49975865(+) TCCCGT/ACTCTA 3 -- us2k18Minor allele frequency- A:0.28NA CSA EA 252
rs1826063501,2
--49975871(+) CTCTAC/TTAAAA 3 -- us2k10--------
rs1889143231,2
--49975978(+) GCAGTA/GAGCCA 3 -- us2k10--------
rs621280741,2
F--49976060(+) AGGAGT/ACTTCT 3 -- us2k12Minor allele frequency- A:0.02NA 122

HapMap Linkage Disequilibrium report for FLT3LG (49977464 - 49990894 bp)

Structural Variations
     Database of Genomic Variants (DGV) 7 variations for FLT3LG:    About this table     
Variant IDTypeSubtypePubMed ID
nsv833862CNV Loss17160897
nsv912262CNV Loss21882294
nsv912264CNV Loss21882294
nsv833863CNV Loss17160897
nsv912261CNV Loss21882294
nsv912265CNV Loss21882294
nsv9739CNV Gain+Loss18304495

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 600007    OMIM disorders: --

20/35 diseases for FLT3LG (see all 35):    About MalaCards
stem cell leukemia    tetanus    leukopenia    aplastic anemia
langerhans-cell histiocytosis    vaccinia    histiocytosis    allergic asthma
herpes simplex    myelodysplastic syndromes    autoimmune thyroiditis    severe combined immunodeficiency
papilloma    non-hodgkin lymphoma    thrombocytopenia    hodgkin's lymphoma
glioblastoma    encephalomyelitis    acute myeloid leukemia    peritonitis


FLT3LG for disorders           About GeneDecksing

10/25 Novoseek inferred disease relationships for FLT3LG gene (see all 25)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
glioblastoma multiforme 52.6 1 17522335 (1)
glioma 36.7 7 15564139 (2), 18079358 (2), 16103070 (1), 20375153 (1) (see all 5)
brain tumors 35.1 2 15564139 (1), 18431473 (1)
anemia aplastic 32.1 2 8977241 (1), 9216732 (1)
leukemia 26.7 5 10766177 (2), 10037010 (1), 8977241 (1)
herpes simplex 26.3 6 20375153 (2), 17228266 (1), 18431473 (1), 18079358 (1) (see all 5)
t-all 25.1 1 8641369 (1)
tumors 21.3 39 9270021 (5), 11099317 (2), 10640965 (1), 9834229 (1) (see all 20)
necrosis 19.9 9 10640965 (1), 9834229 (1), 18547160 (1), 12445738 (1) (see all 8)
melanoma 16.8 4 12000870 (1)

Genetic Association Database (GAD): FLT3LG
Human Genome Epidemiology (HuGE) Navigator: FLT3LG (1 document)

Export disorders for FLT3LG gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for FLT3LG gene, integrated from 9 sources (see all 214):
(articles sorted by number of sources associating them with FLT3LG)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs. (PubMed id 8145851)1, 2, 3 Hannum C.... Lee F. (1994)
  2. Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots. (PubMed id 10881197)1, 2, 9 Savvides S.N.... Karplus P.A. (2000)
  3. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  5. Identification of soluble and membrane-bound isoforms of the murine flt3 ligand generated by alternative splicing of mRNAs. (PubMed id 7824267)1, 3 Lyman S.D....Cleveland L.S. (1995)
  6. Structural analysis of human and murine flt3 ligand genomic loci. (PubMed id 7566977)1, 2 Lyman S.D....Escobar S. (1995)
  7. Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells. (PubMed id 8180375)1, 2 Lyman S.D.... McKenna H.J. (1994)
  8. The membrane-bound isoform of stem cell factor synergizes with soluble flt3 ligand in supporting early hematopoietic cells in long-term cultures of normal and aplastic anemia bone marrow. (PubMed id 9590652)1, 9 Slanicka Krieger M....Wodnar-Filipowicz A. (1998)
  9. Flt3 ligand enhances thymic-dependent and thymic-independent immune reconstitution. (PubMed id 15226184)1, 9 Fry T.J....Mackall C.L. (2004)
  10. Antiapoptotic cytokine IL-3 + SCF + FLT3L influence on proliferation of gamma-irradiated AC133+/CD34+ progenitor cells. (PubMed id 12002675)1, 9 Vavrova J....Filip S. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 2323 HGNC: 3766 AceView: FLT3LG Ensembl:ENSG00000090554 euGenes: HUgn2323
ECgene: FLT3LG Kegg: 2323 H-InvDB: FLT3LG

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for FLT3LG Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for FLT3LG Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for FLT3LG gene:
Search GeneIP for patents involving FLT3LG

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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