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FLT3 Gene

protein-coding   GIFtS: 71
GCID: GC13M028577

Fms-Related Tyrosine Kinase 3

  See FLT3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fms-Related Tyrosine Kinase 31 2     FL Cytokine Receptor2 3
Fms-Like Tyrosine Kinase 32 3     EC 2.7.10.13 8
Stem Cell Tyrosine Kinase 12 3     Fetal Liver Kinase 22
CD1352 3     Growth Factor Receptor Tyrosine Kinase Type III2
FLK-22 3     Receptor-Type Tyrosine-Protein Kinase FLT32
FLK22 3     FLT-33
STK-12 3     Fetal Liver Kinase-23
STK12 3     EC 2.7.108
CD135 Antigen2 3     

External Ids:    HGNC: 37651   Entrez Gene: 23222   Ensembl: ENSG000001220257   OMIM: 1363515   UniProtKB: P368883   

Export aliases for FLT3 gene to outside databases

Previous GC identifers: GC13M026557 GC13M022557 GC13M027507 GC13M026375 GC13M027475 GC13M009398


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FLT3 Gene:
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an
extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic
kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the
fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma
membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently
phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis,
proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the
constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
(provided by RefSeq, Jul 2008)

GeneCards Summary for FLT3 Gene:
FLT3 (fms-related tyrosine kinase 3) is a protein-coding gene. Diseases associated with FLT3 include minimally differentiated acute myeloblastic leukemia, and leukemia, acute myeloid, reduced survival in. GO annotations related to this gene include phosphatidylinositol 3-kinase binding and protein homodimerization activity. An important paralog of this gene is FLT4.

UniProtKB/Swiss-Prot: FLT3_HUMAN, P36888
Function: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates
differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes
phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS
signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes
phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type
FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity
promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways

summary for FLT3 Gene:
FMS-like receptor tyrosine kinase-3 (FLT3) is a member of the class III RTK (receptor tyrosine kinase)
family and is expressed primarily in hematopoietic progenitor cells. The expression within these cells
demonstrates that FLT3 has an important role in the pathogenesis of AML (acute myelogenous leukemia), under
which conditions wild type receptors are overexpressed or mutated forms of the receptor are present.
Inhibitors of both mutated and wild type receptors are therefore of interest in a therapeutic context.

Gene Wiki entry for FLT3 (CD135) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NC_018924.2  NT_024524.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the FLT3 gene promoter:
         STAT5B   Pax-5   AP-1   ATF-2   GATA-2   C/EBPalpha   STAT3   c-Jun   NF-kappaB1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFLT3 promoter sequence
   Search Chromatin IP Primers for FLT3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FLT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12   Ensembl cytogenetic band:  13q12.2   HGNC cytogenetic band: 13q12

FLT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FLT3 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M028577:  view genomic region     (about GC identifiers)

Start:
28,577,411 bp from pter      End:
28,674,729 bp from pter
Size:
97,319 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FLT3_HUMAN, P36888 (See protein sequence)
Recommended Name: Receptor-type tyrosine-protein kinase FLT3 precursor  
Size: 993 amino acids; 112903 Da
Subunit: Monomer in the absence of bound FLT3LG. Homodimer in the presence of bound FLT3LG. Interacts with FIZ1
following ligand activation (By similarity). Interacts with FES, FER, LYN, FGR, HCK, SRC and GRB2. Interacts with
PTPRJ/DEP-1 and PTPN11/SHP2
Miscellaneous: Can be used as diagnostic tool to establish the exact cause of acute myeloid leukemia, and to
determine the optimal therapy
3 PDB 3D structures from and Proteopedia for FLT3:
1RJB (3D)        3QS7 (3D)        3QS9 (3D)    
Secondary accessions: A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414
Alternative splicing: 2 isoforms:  P36888-1   P36888-2   

Explore the universe of human proteins at neXtProt for FLT3: NX_P36888

Explore proteomics data for FLT3 at MOPED

Post-translational modifications: 

  • N-glycosylated, contains complex N-glycans with sialic acid1
  • Autophosphorylated on several tyrosine residues in response to FLT3LG binding. FLT3LG binding also increases
    phosphorylation of mutant kinases that are constitutively activated. Dephosphorylated by PTPRJ/DEP-1, PTPN1,
    PTPN6/SHP-1, and to a lesser degree by PTPN12. Dephosphorylation is important for export from the endoplasmic
    reticulum and location at the cell membrane1
  • Rapidly ubiquitinated by UBE2L6 and the E3 ubiquitin-protein ligase SIAH1 after autophosphorylation, leading to
    its proteasomal degradation1
  • Ubiquitination2 at Lys614, Lys623
  • Glycosylation2 at Asn43, Asn100, Asn151, Asn306, Asn323, Asn351, Asn354, Asn473, Asn502, Asn541
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for FLT3 (P36888) (see all 13)
     VAVKMLK  RDLAARN  ALMSELK  WEIFSLG 


    See FLT3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004110.2  
    ENSEMBL proteins: 
     ENSP00000241453   ENSP00000370374   ENSP00000370369   ENSP00000438139  

    FLT3 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant FLT3 Protein
    R&D Systems Recombinant & Natural Proteins for FLT3 (Flt-3/Flk-2)
    Enzo Life Sciences proteins for FLT3
    OriGene Purified Proteins for FLT3
    OriGene Protein Over-expression Lysate for FLT3
    OriGene MassSpec for FLT3
    OriGene Custom Protein Services for FLT3
    GenScript Custom Purified and Recombinant Proteins Services for FLT3
    Novus Biologicals FLT3 Proteins
    Novus Biologicals FLT3 Lysate
    Sino Biological Recombinant Protein for FLT3
    Sino Biological Cell Lysate for FLT3
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for FLT3 

     
    antibodies-online proteins for FLT3 (16 products) 

     
    antibodies-online peptides for FLT3

    FLT3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of FLT3
    R&D Systems Antibodies for FLT3 (Flt-3/Flk-2)
    Cell Signaling Technology (CST) Antibodies for FLT3 
    OriGene Antibodies for FLT3
    OriGene Custom Antibody Services for FLT3
    Novus Biologicals FLT3 Antibodies
    Search for Antibodies for FLT3 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for FLT3
    antibodies-online antibodies for FLT3 (269 products) 

    FLT3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FLT3
    R&D Systems ELISAs for FLT3 (Flt-3/Flk-2)         (see all)
    GenScript FLT3-Activity-based Kinase Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for FLT3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for FLT3 
    antibodies-online kits for FLT3 (18 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: fms-related tyrosine kinase 3
    PDGF (platelet-derived growth factor) receptor family
    PDGF (platelet-derived growth factor) receptor family

    Selected InterPro protein domains (see all 12):
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold
     IPR000719 Prot_kinase_dom
     IPR001824 Tyr_kinase_rcpt_3_CS

    Graphical View of Domain Structure for InterPro Entry P36888

    ProtoNet protein and cluster: P36888

    2 Blocks protein domains:
    IPB003599 Immunoglobulin subtype
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: FLT3_HUMAN, P36888
    Domain: The juxtamembrane autoregulatory region is important for normal regulation of the kinase activity and for
    maintaining the kinase in an inactive state in the absence of bound ligand. Upon tyrosine phosphorylation, it
    mediates interaction with the SH2 domains of numerous signaling partners. In-frame internal tandem duplications
    (ITDs) result in constitutive activation of the kinase. The activity of the mutant kinase can be stimulated
    further by FLT3LG binding
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with FLT3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FLT3_HUMAN, P36888
    Function: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates
    differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes
    phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS
    signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes
    phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type
    FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity
    promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Present in an inactive conformation in the absence of bound ligand. FLT3LG binding leads to
    dimerization and activation by autophosphorylation

         Genatlas biochemistry entry for FLT3:
    fms-related receptor tyrosine kinase 3,expressed on endothelial cell,duplicated in childhood acute myeloid
    leukemia with poor prognosis and acute lymphoblastic leukemia but not in myelodysplastic syndrome

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004714transmembrane receptor protein tyrosine kinase activity TAS19549778
    GO:0004896cytokine receptor activity ISS--
    GO:0005021vascular endothelial growth factor-activated receptor activity TAS8394751
         
    Find genes that share ontologies with FLT3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for FLT3:
     Decreased substrate adherent c  Decreased viability 

         7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Flt3):
     cellular  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  tumorigenesis 

    Find genes that share phenotypes with FLT3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Flt3tm1Irl for FLT3

       genOway: Develop your customized and physiologically relevant rodent model for FLT3

    miRNA
    Products:
        
    miRTarBase miRNAs that target FLT3:
    hsa-mir-335-5p (MIRT017462), hsa-mir-150-5p (MIRT007053)

    Block miRNA regulation of human, mouse, rat FLT3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FLT3 (see all 33):
    hsa-miR-3194-5p hsa-miR-15a hsa-miR-1245 hsa-miR-139-5p hsa-miR-3074-3p hsa-miR-570 hsa-miR-3142 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidFLT3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FLT3
    Predesigned siRNA for gene silencing in human, mouse, rat FLT3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FLT3

    Clone
    Products:
         
    OriGene clones in human, mouse for FLT3 (see all 8)
    OriGene ORF clones in mouse, rat for FLT3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FLT3 (NM_004119)
    Sino Biological Human cDNA Clone for FLT3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FLT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLT3
    Addgene plasmids for FLT3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FLT3
    Browse ESI BIO Cell Lines and PureStem Progenitors for FLT3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLT3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FLT3_HUMAN, P36888: Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen.
    Note=Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to
    the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen.
    The activated kinase is rapidly targeted for degradation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane4
    extracellular2
    nucleus2
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005788endoplasmic reticulum lumen IEA--
    GO:0005887integral component of plasma membrane TAS8394751
    GO:0009986cell surface IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with FLT3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FLT3 About   (see all 17)  
    See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    Endothelin-1 Signaling Pathway0.46
    Cytokine-cytokine receptor interaction0.43
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    3ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    5Actin Nucleation by ARP-WASP Complex
    Actin Nucleation and Branching0.66
    CDC42 Pathway0.41
    Actin Nucleation by ARP-WASP Complex0.66


    Find genes that share SuperPaths with FLT3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FLT3 (see all 29)
        FLT3 Signaling
    MAPK Signaling
    Paxillin Interactions
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer

    1 Cell Signaling Technology (CST) Pathway for FLT3
        Tyrosine Kinases / Adaptors

    1 GeneGo (Thomson Reuters) Pathway for FLT3
        Development Flt3 signaling


    1 PharmGKB Pathway for FLT3
        Sorafenib Pharmacodynamics

    5 Kegg Pathways  (Kegg details for FLT3):
        Cytokine-cytokine receptor interaction
    Hematopoietic cell lineage
    Pathways in cancer
    Transcriptional misregulation in cancer
    Acute myeloid leukemia

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FLT3: 
              Antigen Presenting Cells in human mouse rat
              Lymphoma in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FLT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FLT3 (P368881, 2, 3 ENSP000002414534) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279861, 2, 3, ENSP000002743354EBI-3946257,EBI-79464 MINT-7103574 MINT-7103585 I2D: score=2 STRING: ENSP00000274335
    PTPN11Q061242, 3, ENSP000003409444MINT-8030324 MINT-8030340 I2D: score=1 STRING: ENSP00000340944
    IKBKGQ9Y6K91, 3, ENSP000003586224EBI-3946257,EBI-81279 I2D: score=1 STRING: ENSP00000358622
    SOCS1O155243, ENSP000003294184I2D: score=4 STRING: ENSP00000329418
    INPP5DQ928353, ENSP000003525754I2D: score=3 STRING: ENSP00000352575
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001776leukocyte homeostasis ISS--
    GO:0002318myeloid progenitor cell differentiation ISS--
    GO:0002320lymphoid progenitor cell differentiation ----
    GO:0002328pro-B cell differentiation ISS--
    GO:0002572pro-T cell differentiation IEA--

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for FLT3 (see all 12)     About this table
    CompoundAction CAS #
    Amuvatinib (MP-470, HPK 56)Multi-kinase inhibitor, inhibits PDGFR, c-Kit, and Flt3[850879-09-3]
    AST 487high selectivity and potency toward FLT3[630124-46-8]
    Cabozantinib (XL184, BMS-907351)Multi-target kinase inhibitor, inhibits c-Met, VEGFR2, and RET[849217-68-1]
    KW 2449multiple-targeted inhibitor, mostly for Flt3[1000669-72-6]
    LestaurtinibPotent JAK2, FLT3 and TrkA inhibitor[111358-88-4]
    Linifanib (ABT-869)ATP-competitive, multi-targeted RTK inhibitor[796967-16-3]
    Ponatinib (AP24534)pan-BCR-ABL inhibitor[943319-70-8]
    Quizartinib (AC220)Potent and selective FLT3 inhibitor[950769-58-1]
    SB1317inhibits CDKs 1, 2, 7 and 9 together with JAK2 and FLT3[937270-47-8]
    SU5416VEGF receptor inhibitor and an aryl hydrocarbon receptor (AHR) agonist[204005-46-9]

    Compounds for FLT3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TCS 359Potent FLT3 inhibitor[301305-73-7]
    5'-FluoroindirubinoximeFLT3 inhibitor; displays antiproliferative activity[861214-33-7]

    2 HMDB Compounds for FLT3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    3 DrugBank Compounds for FLT3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    SunitinibSU011248 (see all 2)557795-19-4targetmultitarget14654525 12531805 15304385 15180525 11752352 14753710
    Sorafenib-- 284461-73-0targetantagonist17229632 17205056
    Ponatinib -- 943319-70-8targetinhibitor23430109

    1 IUPHAR Ligand for FLT3 (fms-related tyrosine kinase 3)    About this table
    LigandTypeActionAffinityPubmed IDs
    Fms-related tyrosine kinase 3 ligand
    NoneNone--

    Selected Novoseek inferred chemical compound relationships for FLT3 gene (see all 40)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pkc 412 91.7 85 17330105 (5), 18071308 (5), 15956279 (4), 15150124 (4) (see all 27)
    lestaurtinib 88.1 22 16868253 (4), 16857985 (2), 20141349 (2), 18341639 (2) (see all 7)
    tyrosine 85.3 556 17851558 (7), 15345597 (4), 9737679 (3), 14726387 (3) (see all 99)
    tandutinib 84.9 24 16902153 (4), 15256420 (3), 15242881 (3), 19625780 (3) (see all 6)
    ag-1296 80.8 21 11455967 (7), 12357354 (2), 17050201 (2), 18509353 (2) (see all 6)
    sunitinib 74.2 28 17889720 (4), 17041096 (3), 17591828 (1), 18192256 (1) (see all 20)
    daniplestim 67.8 1 10781904 (1)
    imatinib 67.8 30 18797870 (3), 14976243 (2), 15180525 (2), 11290609 (1) (see all 13)
    sorafenib 67.5 37 17229632 (6), 18230792 (4), 17889720 (4), 17205056 (2) (see all 20)
    su5416 62.1 11 15158089 (5), 12351406 (2), 17169805 (1), 12649163 (1) (see all 5)



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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FLT3 gene: 
    NM_004119.2  

    Unigene Cluster for FLT3:

    Fms-related tyrosine kinase 3
    Hs.507590  [show with all ESTs]
    Unigene Representative Sequence: NM_004119
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000241453(uc001urw.3 uc010aao.3 uc010tdn.2) ENST00000380987
    ENST00000469894 ENST00000380982 ENST00000537084
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FLT3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FLT3 (see all 33):
    hsa-miR-3194-5p hsa-miR-15a hsa-miR-1245 hsa-miR-139-5p hsa-miR-3074-3p hsa-miR-570 hsa-miR-3142 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidFLT3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FLT3
    Predesigned siRNA for gene silencing in human, mouse, rat FLT3
    Clone
    Products:
         
    OriGene clones in human, mouse for FLT3 (see all 8)
    OriGene ORF clones in mouse, rat for FLT3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FLT3 (NM_004119)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FLT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLT3
    Addgene plasmids for FLT3 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FLT3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FLT3
      QuantiTect SYBR Green Assays in human, mouse, rat FLT3
      QuantiFast Probe-based Assays in human, mouse, rat FLT3

    Additional mRNA sequence: 

    BC126350.1 BC144039.1 BC144040.1 L36162.1 U02687.1 Z26652.1 

    4 DOTS entries:

    DT.120782229  DT.104253  DT.75174632  DT.91675080 

    17 AceView cDNA sequences:

    BF589957 BC036028 BX279530 BU681356 L36162 AW059681 U02687 NM_004119 
    AV713950 Z26652 AW772610 AI150354 BI461248 AW057705 BF170536 BF176247 
    BF170584 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FLT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTGATTCCA
    FLT3 Expression
    About this image


    FLT3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 17 entries
             Common Lymphoid Progenitor Cells Hematopoietic Bone Marrow
             Bone Marrow CD133+ Cells   
             clps   
     
     Umbilical Cord (Extraembryonic Tissues)
             stem cells (umbilical cord cd34+)   
     
     Bone (Muscoskeletal System)
             BONE MARROW   
    FLT3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FLT3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.507590

    UniProtKB/Swiss-Prot: FLT3_HUMAN, P36888
    Tissue specificity: Detected in bone marrow, in hematopoietic stem cells, in myeloid progenitor cells and in
    granulocyte/macrophage progenitor cells (at protein level). Detected in bone marrow, liver, thymus, spleen and
    lymph node, and at low levels in kidney and pancreas. Highly expressed in T-cell leukemia

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FLT3: 
              Antigen Presenting Cells in human mouse rat
              Lymphoma in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FLT3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FLT3
    QuantiTect SYBR Green Assays in human, mouse, rat FLT3
    QuantiFast Probe-based Assays in human, mouse, rat FLT3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FLT3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Flt31 , 5 FMS-like tyrosine kinase 31, 5 83.15(n)1
    86.18(a)1
      5 (86.88 cM)5
    142551  NM_010229.21  NP_034359.21 
     1473307415 
    chicken
    (Gallus gallus)
    Aves FLT31 fms-related tyrosine kinase 3 65.12(n)
    57.13(a)
      100858422  XM_003640612.2  XP_003640660.2 
    lizard
    (Anolis carolinensis)
    Reptilia FLT36
    fms-related tyrosine kinase 3
    52(a)
    1 ↔ 1
    3(185864344-185941774)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia flt31 fms-related tyrosine kinase 3 59.73(n)
    51.99(a)
      101733150  XM_004912385.1  XP_004912442.1 
    zebrafish
    (Danio rerio)
    Actinopterygii flt31 fms-related tyrosine kinase 3 53.5(n)
    45.67(a)
      566708  XM_001921725.2  XP_001921760.2 


    ENSEMBL Gene Tree for FLT3 (if available)
    TreeFam Gene Tree for FLT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for FLT3 gene
    FLT42  FGFR42  PDGFRB2  CSF1R2  KIT2  FGFR32  PDGFRA2  RET2  
    KDR2  FGFR12  FGFR22  FLT12  
    16 SIMAP similar genes for FLT3 using alignment to 3 protein entries:     FLT3_HUMAN (see all proteins):
    STK-1    RET    NIN/PDGFRB fusion    ABL1    KIT    FES
    CSF1R    FGR    urf-ret    EPHA2    DKFZp686M05208    CDK4
    FGFR2    tec    PDGFRA    TIE1

    Find genes that share paralogs with FLT3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FLT3 (see all 2552)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0656834
    Acute lymphoblastic leukemia patients4--see VAR_0656832 D Y mis40--------
    VAR_0656824
    Acute lymphoblastic leukemia patients4--see VAR_0656822 D V mis40--------
    VAR_0656844
    Acute lymphoblastic leukemia patients4--see VAR_0656842 I M mis40--------
    VAR_0656804
    Acute lymphoblastic leukemia patients4--see VAR_0656802 D H mis40--------
    VAR_0656814
    Acute lymphoblastic leukemia patients4--see VAR_0656812 D N mis40--------
    VAR_0656794
    Acute lymphoblastic leukemia patients4--see VAR_0656792 D E mis40--------
    rs1219096461,2
    Cother19547186(-) TCGAGA/TTATCA 2 D V mis10--------
    rs1219134881,2
    Cother19547187(-) CTCGAA/C/G/
            
    ATATC
    4 N H D Y mis10--------
    rs1816549321,2
    --9531466(+) GTTCCA/GGATCC 1 -- ds50010--------
    rs1870561381,2
    C--9531491(+) CTACAC/TGCAAC 1 -- ds50010--------
    rs19993651,2
    H--9531514(-) CTCTTC/TTTTCT 1 -- ds50014Minor allele frequency- T:0.00NS EA 398
    rs740415251,2
    C,F--9531545(+) TCGTGT/AAAGCG 1 -- ds50012Minor allele frequency- A:0.05WA 120
    rs19993641,2
    C,F,A,H--9531585(-) GGCTTA/C/GTGAAC 1 -- ds500130NS EA NA WA 2970
    rs1388492321,2
    --9531638(+) GGTCGC/TCATGG 1 -- ds50010--------
    rs1420271851,2
    C--9531983(+) CTTTAC/TTGAAA 1 -- ut310--------
    rs2017557491,2
    C--9531985(+) TTATT-/GAA   
       AATAC
    TAATC
    1 -- ut310--------
    rs1463731791,2
    --9532001(+) TCCTCA/CATGTT 1 -- ut310--------
    rs1909041781,2
    --9532075(+) TGGTAG/TAACAC 1 -- ut310--------
    rs356130521,2
    C--9532104(+) CCCCAA/GTACAA 1 -- ut313Minor allele frequency- G:0.06NA WA 240
    rs734369301,2
    C--9532132(+) ATCTTG/AGGCTG 1 -- ut311Minor allele frequency- A:0.50WA 2
    rs1819541541,2
    --9532171(+) TGTATC/TTTGGG 1 -- ut310--------
    rs1384347051,2
    C--9532189(+) CACACA/GTGCTC 1 -- ut310--------
    rs1851375041,2
    --9532194(+) GTGCTC/TTGGAA 1 -- ut310--------
    rs592517521,2
    C,F--9532223(+) TGGGTG/TCACAA 1 -- ut312Minor allele frequency- T:0.04WA 120
    rs38293821,2
    C,F,A,H--9532238(+) AGGGGG/TTTCGT 1 -- ut31 ese329Minor allele frequency- N:0.00NS EA NA WA CSA 2982
    rs1115524381,2
    C,F--9532364(+) TTACAT/CATTAT 1 -- ut312Minor allele frequency- C:0.02CSA WA 120
    rs1898443591,2
    --9532389(+) TTAAAA/GAATCA 1 -- ut310--------
    rs1824117421,2
    C--9532515(+) CTCCAA/GTAAAG 1 -- ut310--------
    rs1878828241,2
    --9532741(+) CCTCTA/GCGAAT 2 Q * stop-lost0--------
    rs1429222281,2
    C,F--9532742(+) CTCTAC/TGAATC 2 S syn11Minor allele frequency- T:0.00NA 4550
    rs740415261,2
    C,F--9532759(+) CTGAGC/GCTGCG 2 P A mis13Minor allele frequency- G:0.01WA NA 4670
    rs560271151,2
    C,F--9532763(+) GCCTGC/TGGAGA 2 P syn13Minor allele frequency- T:0.05CSA WA NA 4672
    rs1401233331,2
    C,F--9532771(+) AGAGAG/ATAGCC 2 /L /F mis11Minor allele frequency- A:0.00NA 4550
    rs1443972691,2
    C,F--9532803(+) AAGGTC/TGCCTG 2 Q R mis11Minor allele frequency- T:0.00NA 4550
    rs1915014931,2
    C--9532804(+) AGGTCA/GCCTGT 2 R * stg10--------
    rs1832937261,2
    C--9532832(+) CATTCC/TGAAAC 2 S syn10--------
    rs1380033471,2
    C--9532833(+) ATTCCG/AAAACA 2 /S /L mis11Minor allele frequency- A:0.00NA 4550
    rs1487843071,2
    --9532922(+) TATGCA/GCCCAT 1 -- int10--------
    rs802173471,2
    C,F--9533069(+) TTCACC/TGTGGC 1 -- int12Minor allele frequency- T:0.04WA 120
    rs1886925991,2
    C--9533369(+) AAGTAC/TTTTTA 1 -- int10--------
    rs43048981,2
    C,F,H--9533507(+) GTCACT/CCTAGA 1 -- int120Minor allele frequency- C:0.01NA NS EA WA CSA 932
    rs1420858181,2
    C--9533625(+) TTCACA/GACTTT 1 -- int10--------
    rs1923101511,2
    --9533739(+) AGGCCG/TGGCGC 1 -- int10--------
    rs1846939361,2
    --9533765(+) TAATCC/GCAGCA 1 -- int10--------
    rs1507163171,2
    C--9533882(+) ATGGCA/GGCGCG 1 -- int10--------
    rs47712031,2
    C,F,H--9534027(+) AAGAAA/GAAAGG 1 -- int1 trp318Minor allele frequency- G:0.13NS EA NA CSA WA 2337
    rs1395942941,2
    --9534137(+) ATTTTC/GAATTA 1 -- int10--------
    rs1451053511,2
    --9534185(+) TGTCAC/TATATT 1 -- int10--------
    rs1475806821,2
    C--9534214(+) TGGCCA/GCATAT 1 -- int10--------
    rs1879192741,2
    --9534234(+) ACGGCA/GGCCTA 1 -- int10--------
    rs1912208491,2
    --9534292(+) TTATAC/TGAAAC 1 -- int10--------
    rs734369321,2
    C--9534444(+) ATCAAC/TGGTGC 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1405196241,2
    --9534463(+) TATATC/TTTCCA 1 -- int10--------
    rs1845979201,2
    C--9534527(+) AGCAAA/GAAGTT 1 -- int10--------
    rs1894628901,2
    --9534571(+) CAAAGC/TTGGGC 1 -- int10--------
    rs1814596621,2
    --9534884(+) ATTTGC/TTCCGT 1 -- int10--------
    rs1497080991,2
    C--9534887(+) TGTTCC/TGTTCC 1 -- int10--------
    rs734369371,2
    C,F--9534902(+) GCCCTC/TGTTAC 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1446252881,2
    C--9534994(+) AAATT-/ATGT  
      
    /GT/TG
    gtgtg
    1 -- int10--------
    rs1455072421,2
    C--9534994(+) AAAAT-/TGTGTG
            
    TGTGT
    1 -- int10--------
    rs287593441,2
    --9534995(+) AAATTA/GTGTGT 1 -- int10--------
    rs40027731,2
    C--9535028(+) tgtgt-/GT    
       
    /GTGT
    NNNAT
    1 -- int10--------
    rs1456747391,2
    --9535071(+) GTTGCA/GCAATG 1 -- int10--------
    rs1126927931,2
    C,F--9535137(+) TGAAGT/CAGACA 1 -- int13Minor allele frequency- C:0.05NA 124
    rs740415271,2
    C,F--9535213(+) AACCAC/GCTCAT 1 -- int12Minor allele frequency- G:0.06WA 120
    rs73181181,2
    C,F,H--9535266(+) CACCTG/AAATTA 1 -- int18Minor allele frequency- A:0.01NS EA NA WA 678
    rs1450294161,2
    C--9535333(+) GACAA-/TCTCTCT 1 -- int10--------
    rs1890958051,2
    --9535482(+) AGGCTA/GGAGTG 1 -- int10--------
    rs1489011681,2
    --9535507(+) CAGCTC/TACAGC 1 -- int10--------
    rs1432569611,2
    --9535579(+) TACCAC/TCACAC 1 -- int10--------
    rs1817608651,2
    --9535622(+) AGGGTG/TTCACC 1 -- int10--------
    rs73233451,2
    C,F,A--9535697(+) TGCTGC/GGATTA 1 -- int16Minor allele frequency- G:0.25NA WA 12
    rs1404819831,2
    C--9535729(+) AGCCAC/TTGTTG 1 -- int10--------
    rs44669451,2
    C,H--9535856(+) AAGTAC/TATAAA 1 -- int116Minor allele frequency- T:0.00NS EA NA WA CSA 778
    rs1863805721,2
    C--9535998(+) GTGCAA/GTCACA 1 -- int10--------
    rs1457092361,2
    --9536026(+) CCTCCC/TAGGCA 1 -- int10--------
    rs1911334871,2
    --9536027(+) CTCCTA/CGGCAG 1 -- int10--------
    rs558273681,2
    C,F--9536082(+) GTGTGC/TGCCAC 1 -- int12Minor allele frequency- T:0.06WA 120
    rs1382787771,2
    C--9536091(+) ACTACA/GCCTGG 1 -- int10--------
    rs1177171611,2
    F--9536125(+) GATGGG/AGTCCC 1 -- int11Minor allele frequency- A:0.01NA 120
    rs1429580991,2
    --9536213(+) ACAGGC/GGTGAG 1 -- int10--------
    rs1502441181,2
    --9536372(+) TACCAC/TGTTAC 1 -- int10--------
    rs740415281,2
    C,F--9536403(+) TCTCTG/CTGCCT 1 -- int12Minor allele frequency- C:0.04WA 120
    rs1807552461,2
    --9536690(+) CTCTCC/TACCTT 1 -- int10--------
    rs1861393541,2
    --9536708(+) ATTGTC/TGTTTG 1 -- int10--------
    rs1910136061,2
    --9536848(+) ACAACA/GTAGCA 1 -- int10--------
    rs95129711,2
    C,F--9536860(+) GATCCC/TCATCT 1 -- int17Minor allele frequency- T:0.28NA WA EA 366
    rs1832820891,2
    --9536862(+) TCCCCA/CTCTCT 1 -- int10--------
    rs1389723261,2
    --9536917(+) GGATCA/GCTTGA 1 -- int10--------
    rs1871839841,2
    --9536923(+) CTTGAA/TTCCAG 1 -- int10--------
    rs586368081,2
    C--9536984(+) AAAAA-/A/AA  
            
    GGAAA
    1 -- int11NA 2
    rs2014214211,2
    --9537062(+) GGTAA-/CTCTCAC 1 -- int10--------
    rs1494266461,2
    C--9537253(+) CCTCCA/GCCTCC 1 -- int10--------
    rs1444553801,2
    C--9537259(+) CCTCCC/TGGTTT 1 -- int10--------
    rs1904597171,2
    --9537260(+) CTCCCA/GGTTTC 1 -- int10--------
    rs1830061671,2
    --9537425(+) ACTCCC/GAAAGT 1 -- int10--------
    rs1394777571,2
    --9537502(+) CTTTTC/TTGGTT 1 -- int10--------
    rs1876821031,2
    --9537671(+) TTTATC/TTTATT 1 -- int10--------
    rs128745291,2
    C,F,H--9537716(+) TGGAGT/CGCAGC 1 -- int114Minor allele frequency- C:0.13NS EA NA WA 1192
    rs1423877101,2
    C--9537729(+) CCAGT-/TATA  
            
    TATAG
    1 -- int10--------
    rs1926004401,2
    --9537732(+) AGTTAG/TAGCTC 1 -- int10--------
    rs1433827751,2
    --9537769(+) GGGAAC/TCCTCC 1 -- int10--------
    rs717079801,2
    C--9537874(+) CTCTTC/-CCCCA 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1841711911,2
    --9537910(+) ATGGTA/CATTTT 1 -- int10--------
    rs1471686301,2
    C--9537950(+) GTTACA/GTTTCT 1 -- int10--------
    rs802148241,2
    C--9538044(+) ACTTCC/TGCAGT 1 -- int10--------
    rs24819551,2
    C,F,A,H--9538131(+) TCTGCG/AGTGCA 1 -- int126Minor allele frequency- A:0.40NS EA NA WA CSA 2746
    rs1879125981,2
    --9538154(+) TTCATC/TGTCTC 1 -- int10--------
    rs95791411,2
    C,F,H--9538207(+) TTACTA/GTCAAA 1 -- int118Minor allele frequency- N:0.00NA NS EA WA 1416
    rs791855591,2
    --9538213(+) TCAAAA/GCCAAT 1 -- int10--------
    rs1174154151,2
    F--9538235(+) TTTTAT/GTTTAG 1 -- int11Minor allele frequency- G:0.04EA 120
    rs1159396711,2
    C,F--9538294(+) GGTTAG/CAGTAC 1 -- int11Minor allele frequency- C:0.09WA 118
    rs1925433341,2
    --9538383(+) GCTGGA/GACCAC 1 -- int10--------
    rs560797201,2
    C,F--9538419(+) ATTTTC/TAAATT 1 -- int13Minor allele frequency- T:0.35WA NA EA 358
    rs95129741,2
    F--9538459(+) GCCCAG/CACTGG 1 -- int12Minor allele frequency- C:0.00NA 4
    rs1848837541,2
    --9538540(+) CACCAC/TGCTTG 1 -- int10--------
    rs1511916731,2
    --9538631(+) CAGACA/CCCTTT 1 -- int10--------
    rs1888469051,2
    --9538695(+) TAGTGC/TGCTCC 1 -- int10--------
    rs1815230881,2
    --9538713(+) TGCCCA/GTCCTT 1 -- int10--------
    rs774946401,2
    F--9538728(+) CTGCCG/ACCCCT 1 -- int11Minor allele frequency- A:0.02WA 118
    rs95129751,2
    H--9538815(+) ttccaG/Caaatg 1 -- int16Minor allele frequency- C:0.00NS EA NA 406
    rs748303561,2
    C,F--9538831(+) TGAGCG/ACCTTC 1 -- int11Minor allele frequency- A:0.10WA 118
    rs1127017271,2
    F--9538840(+) TCCACG/ATGCTA 1 -- int12Minor allele frequency- A:0.02CSA WA 120
    rs1114579971,2
    F--9538863(+) GCAGCG/AGGGTC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs95079761,2
    H--9538868(+) ggggtC/Ttataa 1 -- int14Minor allele frequency- T:0.00NS EA 420
    rs1499639101,2
    --9539066(+) TGAGTC/TTCACA 1 -- int10--------
    rs79845911,2
    C,F,H--9539085(+) CAGCTG/AAAAGT 1 -- int120Minor allele frequency- A:0.09NS EA NA WA CSA 1786
    rs1465084891,2
    --9539139(+) AAATTG/TGGGGA 1 -- int10--------
    rs170862121,2
    C,F,H--9539198(+) ATGTTT/CGTCCA 1 -- int132Minor allele frequency- C:0.26NA EA NS WA CSA 3406
    rs79915311,2
    C,F,H--9539257(+) AATCAT/CGTAAT 1 -- int112Minor allele frequency- C:0.12NS EA NA WA CSA 1216
    rs170862131,2
    C,F,H--9539294(+) TGGTGT/CTGAGG 1 -- int121Minor allele frequency- C:0.26NA NS EA WA CSA 2134
    rs1405225921,2
    C--9539343(+) TTTCCC/TACTCT 1 -- int10--------
    rs1846081741,2
    --9539551(+) CAGGCA/GTGGTG 1 -- int10--------
    rs74908281,2
    C,F,A--9539561(+) ggcagA/Gtgcct 1 -- int14Minor allele frequency- G:0.38NA WA CSA 8
    rs1510845481,2
    C--9539582(+) TACTC-/GAAGAG 1 -- int10--------
    rs1465905281,2
    C--9539598(+) GGCACA/GATAAT 1 -- int10--------
    rs764132441,2
    C--9539677(+) GGAGTG/TAGACT 1 -- int10--------
    rs1128940741,2
    C--9539770(+) GAGGTG/AGGCGG 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1116583731,2
    C--9539817(+) TATGGC/TGAAAC 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1131431731,2
    C--9539818(+) ATGGTG/AAAACT 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1893250201,2
    --9539826(+) ACTCCA/GTCTCT 1 -- int10--------
    rs1504869301,2
    --9539876(+) CCTGTA/CGTCCC 1 -- int10--------
    rs1155978501,2
    C,F--9540069(+) AAAACC/TTTTCA 1 -- int11Minor allele frequency- T:0.11WA 118
    rs1824220261,2
    --9540106(+) GGGAAA/GGTGAC 1 -- int10--------
    rs1124380651,2
    C,F--9540132(+) ACCAAG/AGGACT 1 -- int11Minor allele frequency- A:0.50NA 2
    rs170720371,2
    C,F,H--9540139(+) GACTAG/CATAGG 1 -- int19Minor allele frequency- C:0.13NA NS EA 798
    rs584834381,2
    C--9540200(+) ACCAA-/ACAAAA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1894399971,2
    C--9540245(+) CCACGA/CCAAGC 1 -- int10--------
    rs799043971,2
    C,F--9540287(+) AGGCTG/ACATGA 1 -- int11Minor allele frequency- A:0.09WA 118
    rs1140642551,2
    --9540330(+) CACCCA/GGGGAG 1 -- int10--------
    rs1507926111,2
    C--9540330(+) CACCC-/GGGGAG 1 -- int10--------
    rs1157468861,2
    C--9540331(+) ACCCGA/GGGAGG 1 -- int10--------
    rs1446423751,2
    C--9540343(+) GGCAT-/TTCC/TTCC
    TTCCTTCCTTCC
    TTCCT
    1 -- int10--------
    rs619463231,2
    --9540368(+) CTTCCC/TTCCTC 1 -- int10--------
    rs1131460241,2
    C--9540398(+) TTTCTC/TTTTCT 1 -- int10--------
    rs2005206611,2
    C--9540402(+) TTTCTC/TTCTTT 1 -- int10--------
    rs724171701,2
    C--9540407(+) TTCTT-/TCTC  
            
    TCTTT
    1 -- int10--------
    rs795201431,2
    C--9540410(+) TTTCTT/CTCTTT 1 -- int11Minor allele frequency- C:0.00WA 2
    rs1513167771,2
    C--9540479(+) CTCTT-/TTTC  
            
    TTTCT
    1 -- int10--------
    rs1434199981,2
    C--9540501(+) TTTGAA/GATAGA 1 -- int10--------
    rs769680041,2
    C--9540521(+) TGTCAC/TCCAGG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1810332921,2
    --9540601(+) TCAGCC/TTCCCG 1 -- int10--------
    rs1404372891,2
    C--9540631(+) ATGCGC/TCACCA 1 -- int10--------
    rs731718391,2
    C--9540688(+) GCCTGG/CCTGGT 1 -- int13Minor allele frequency- C:0.28WA NA EA 242
    rs1854069761,2
    --9540745(+) GTGCTA/GGGATT 1 -- int10--------
    rs73171591,2
    C,F,A,H--9540766(+) CCCACT/CGCAAT 1 -- int119Minor allele frequency- C:0.28NS EA NA WA CSA 2320
    rs1492656721,2
    --9540959(+) TTCAAC/TGGTTC 1 -- int10--------
    rs170862141,2
    C,F,H--9540960(+) TCAACG/AGTTCC 1 -- int126Minor allele frequency- A:0.27NA NS EA WA 2910
    rs1444811191,2
    --9541012(+) GACATC/TCTGTG 1 -- int10--------
    rs1484603401,2
    --9541019(+) TGTGAC/GTATGG 1 -- int10--------
    rs1138540271,2
    C--9541034(+) AGGAAAGG/-AGAAG 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1425958501,2
    --9541116(+) TCTCTA/GCTCCC 1 -- int10--------
    rs1902165831,2
    --9541119(+) CTACTA/CCCCCA 1 -- int10--------
    rs1136006691,2
    F--9541447(+) AGCCCG/ATGTCT 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1135671901,2
    C--9541620(+) GTCTC-/AAAAAA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs731718401,2
    C--9541641(+) TATAGC/TTAGAC 1 -- int15Minor allele frequency- T:0.27WA CSA NA EA 362
    rs1399699691,2
    --9541661(+) TGCACA/GTATAC 1 -- int10--------
    rs1172762541,2
    F--9541663(+) CACATA/GTACAT 1 -- int11Minor allele frequency- G:0.03NA 120
    rs95079771,2
    C,F,A--9541681(+) TTACCA/GGCTCA 1 -- int18Minor allele frequency- G:0.43NA WA CSA EA 368
    rs95079781,2
    C,F,A--9541683(+) ACCAGC/ATCACT 1 -- int19Minor allele frequency- A:0.46NA WA EA 370
    rs1827879411,2
    --9541813(+) CCTAAC/TTCTCT 1 -- int10--------
    rs1859314871,2
    --9541950(+) ACAGAA/CAATCC 1 -- int10--------
    rs1179901661,2
    C,F--9542041(+) TACATC/TACCTG 1 -- int11Minor allele frequency- T:0.03NA 120
    rs42382061,2
    C,F,H--9542124(+) AGACTC/TCCCAA 1 -- int116Minor allele frequency- T:0.01NS EA NA WA CSA 793
    rs118435431,2
    H--9542180(+) ccTCAG/ATATTA 1 -- int14Minor allele frequency- A:0.00NS EA 420
    rs44350981,2
    C,F,H--9542385(+) GGACAA/C/GAATTG 1 -- int123NS EA NA WA 2770
    rs1442279671,2
    --9542709(+) CAGCAC/TTTTGG 1 -- int10--------
    rs1164098671,2
    F--9542792(+) TCTACA/GAAAAA 1 -- int11Minor allele frequency- G:0.01WA 118
    rs2011896051,2
    C--9542953(+) GTCTC-/AATA  
            
    AATAA
    1 -- int10--------
    rs1465414221,2
    --9542997(+) CCACAC/TAACTT 1 -- int10--------
    rs79941551,2
    C,H--9543094(+) ACCAAT/CTTCCT 1 -- int14Minor allele frequency- C:0.00NS EA 414
    rs2010250991,2
    C--9543171(+) AAAAAC/TGAAGT 2 S syn10--------
    rs3768973941,2
    C--9543372(+) GCAAGC/TCTCTA 1 -- int10--------
    rs1918296951,2
    --9543396(+) TTCATA/GTCCGA 1 -- int10--------
    rs58024561,2
    C--9543542(+) GCTTT-/GTTCAG 1 -- int10--------
    rs1840676121,2
    --9543772(+) TGGTCA/CTGCAT 1 -- int10--------
    rs40736301,2
    C,F,A,H--9543813(-) ATTTGG/ATTGAA 1 -- int120Minor allele frequency- A:0.40NS EA NA WA CSA 1124
    rs2015048481,2
    C--9543868(+) CTGATC/GCATTT 2 H D mis10--------
    rs2009098941,2
    --9543871(+) ATCCAC/TTTTAA 2 M V mis10--------
    rs563000221,2
    C,F--9543914(+) TCAACC/TGGAAT 2 P syn12Minor allele frequency- T:0.00CSA NA 4552
    rs95791421,2
    C,F,H--9544041(+) AGACAC/GTGTTG 1 -- int115Minor allele frequency- G:0.21NS EA NA WA 1206
    rs95791431,2
    C,F,H--9544055(+) GCACAC/TGGGCT 1 -- int124Minor allele frequency- T:0.20NS EA NA CSA WA 2770
    rs1136814031,2
    F--9544062(+) GGCTGC/TGGCTG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs2002281771,2
    --9544203(+) GGGGT-/GGGGGC 1 -- int10--------
    rs44975071,2
    C,F--9544208(+) TGGGGC/GGGCAC 1 -- int19Minor allele frequency- G:0.39NA WA CSA 134
    rs2001757031,2
    --9544271(+) AACTTA/GCCAAG 1 -- spd10--------
    rs1470758071,2
    C--9544370(+) CATTTG/TACAGG 2 V syn10--------
    rs2019237261,2
    --9544380(+) GCAGAC/TGGGCC 2 H R mis10--------
    rs799999781,2
    C,F--9544404(+) GAGGAG/AATAAG 1 -- int11Minor allele frequency- A:0.02WA 118
    rs783219231,2
    --9544576(+) ACATAA/CGGCAT 1 -- int10--------
    rs802873091,2
    F--9544614(+) GGCTTG/ATGCTT 1 -- int11Minor allele frequency- A:0.01EA 120
    rs740415301,2
    C,F--9544688(+) CCAGTC/GAGTTG 1 -- int13Minor allele frequency- G:0.21WA CSA 122
    rs1926990061,2
    --9544717(+) CTAGTA/GAATTA 1 -- int10--------
    rs1823845711,2
    --9544774(+) TGTCAC/TCCACA 1 -- int10--------
    rs1870539991,2
    --9544803(+) CCCACA/GTCATC 1 -- int10--------
    rs44321111,2
    C,F,A,H--9544804(+) CCACGC/TCATCA 1 -- int128Minor allele frequency- T:0.20NS EA NA WA CSA 2483
    rs748921711,2
    F--9544932(+) CTGGGG/ACAGAG 1 -- int11Minor allele frequency- A:0.01WA 118
    rs1918313441,2
    --9544933(+) TGGGGA/CAGAGC 1 -- int10--------
    rs58024571,2
    C--9544969(+) ttttt-/T/TT  
            
    gagac
    1 -- int1 trp31NA 2
    rs40745421,2
    C,F,A,H--9544982(-) AGAGCA/GAAACT 1 -- int15Minor allele frequency- G:0.40NA WA 10
    rs1457981741,2
    C--9545007(+) GAGTGC/TAATGG 1 -- int10--------
    rs1843733121,2
    --9545133(+) TTTTTC/TGTAGA 1 -- int10--------
    rs1890797721,2
    --9545197(+) CCACCC/TGCCTC 1 -- int10--------
    rs1929941201,2
    C--9545267(+) CTTTTA/CCATGG 1 -- int10--------
    rs734369511,2
    C--9545276(+) GGGTTG/AACGAG 1 -- int12Minor allele frequency- A:0.04WA 120
    rs1481995661,2
    --9545345(+) AAATGC/TATGCA 1 -- int10--------
    rs1856471371,2
    --9545491(+) ATATGA/GGCAGT 1 -- int10--------
    rs756726111,2
    F--9545501(+) TCTATG/CATGAG 1 -- int11Minor allele frequency- C:0.03NA 120
    rs1905231881,2
    --9545509(+) GAGTAA/GGAGTA 1 -- int10--------
    rs41289961,2
    C,F,H--9545513(-) GATCTA/CCTCCT 1 -- int125Minor allele frequency- C:0.16NS EA NA WA CSA 2348
    rs1411341581,2
    --9545518(+) TAGATC/TGTAAA 1 -- int10--------
    rs1808094531,2
    --9545519(+) AGATCA/GTAAAT 1 -- int10--------
    rs771638841,2
    F--9545564(+) CAGTTC/TAATTT 1 -- int10--------
    rs755585851,2
    F--9545644(+) CACATC/TAACGC 1 -- int12Minor allele frequency- T:0.08CSA WA 120
    rs1379594791,2
    --9545742(+) CACATC/GCTGTG 1 -- int10--------
    rs773072191,2
    F--9545759(+) TGGGCG/AAGTTA 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1495229901,2
    --9545779(+) GCCTCA/GGTTTC 1 -- int10--------
    rs1851655511,2
    --9545839(+) GATGTG/TTAGCA 1 -- int10--------
    rs93194101,2
    C,F,A,H--9545863(+) AAGTCA/GGCATT 1 -- int127Minor allele frequency- G:0.10NS EA NA WA 3176
    rs1884158921,2
    --9545973(+) GATCAC/GAGCTC 1 -- int10--------
    rs95542201,2
    C--9545990(+) GCCTCA/GACCTC 1 -- int10--------
    rs1129819541,2
    C,F--9546010(+) AGTGAC/TCCTCC 1 -- int11Minor allele frequency- T:0.50WA 2
    rs25042241,2
    C,F--9546036(+) agtagC/Ttgaga 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs602889531,2
    C,F--9546188(+) AAGGCG/ATGAGC 1 -- int14Minor allele frequency- A:0.31WA CSA 124
    rs1462635951,2
    C--9546204(+) GCACCC/GAGCCA 1 -- int10--------
    rs95129771,2
    C,F,H--9546318(+) TACCAA/GGTCAA 1 -- int113Minor allele frequency- G:0.10NS EA NA WA 926
    rs1487213741,2
    --9546338(+) TTTTTG/TTTGTT 1 -- int10--------
    rs2013584151,2
    --9546349(+) TTGTT-/GTTTTT 1 -- int10--------
    rs95129781,2
    C,A--9546350(+) TTGTTG/TTTTTT 1 -- int1 trp31Minor allele frequency- T:0.50NA 2
    rs1422513111,2
    C--9546353(+) TTTTTG/TTTTTT 1 -- int10--------
    rs607834791,2
    C,F--9546568(+) GTATCG/AAACTC 1 -- int12Minor allele frequency- A:0.50WA CSA 4
    rs740415311,2
    C,F--9546693(+) GATGAC/TAAATA 1 -- int11Minor allele frequency- T:0.50WA 2
    rs24912171,2
    C,F,O,A,H--9546710(+) AATTCA/GTATTT 1 -- int113Minor allele frequency- G:0.26NA WA CSA EA 514
    rs1455941161,2
    --9546751(+) GTGCTA/GTATAT 1 -- int10--------
    rs1856884521,2
    --9546853(+) TGCAAA/GTATTG 1 -- int10--------
    rs1477141241,2
    C--9546854(+) GCAAGA/TATTGA 1 -- int10--------
    rs1141991421,2
    C,F--9546936(+) AGGACA/GGATGT 1 -- int11Minor allele frequency- G:0.07WA 118
    rs170862261,2
    C,F,H--9547091(+) TACCAT/CGATAA 1 -- int121Minor allele frequency- C:0.22NA EA NS CSA WA EU 2715
    rs1918435421,2
    C--9547117(+) TAGCCA/GTATAA 1 -- int10--------
    rs1425089681,2
    --9547364(+) GGTACC/TGGTGA 1 -- int10--------
    rs734369581,2
    C,F--9547458(+) TTCTGC/TAGCTA 1 -- int14Minor allele frequency- T:0.27WA CSA 124
    rs1168857471,2
    C,F--9547463(+) CAGCTA/TTGGTG 1 -- int11Minor allele frequency- T:0.02NA 120
    rs1469086421,2
    --9547526(+) AGATCA/TTTTGC 1 -- int10--------
    rs1836122691,2
    --9547551(+) AGTGAC/GAGGCT 1 -- int10--------
    rs1873364941,2
    --9547602(+) CAGAGC/TTGTCC 1 -- int10--------
    rs2018081191,2
    C--9547645(+) CATCTC/TTTTTC 1 -- int10--------
    rs58024581,2
    C--9547652(+) tttttT/-gagac 1 -- int11Minor allele frequency- -:0.00NA 2
    rs619463241,2
    C--9547673(+) GAGACG/AGAGTT 1 -- int11Minor allele frequency- A:0.50NA 2
    rs25042251,2
    C,F,A,H--9547754(+) CAAGCG/AATTCT 1 -- int16Minor allele frequency- A:0.33NA 12
    rs25042261,2
    C,F,A,H--9547841(+) GACGGG/CGTTTC 1 -- int15Minor allele frequency- C:0.40NA 10
    rs42656721,2
    C,F,A--9547846(+) cgtttC/Tgccat 1 -- int13Minor allele frequency- T:0.33NA 6
    rs1114107471,2
    C,F--9547941(+) CACCGC/TGCCTG 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1460074431,2
    --9547956(+) GCATCG/TCTTTT 1 -- int10--------
    rs25042271,2
    C,H--9548087(+) GCTGAG/AAGATG 1 -- int116Minor allele frequency- A:0.00NS EA NA WA CSA 792
    rs750350871,2
    C,F--9548146(+) GAAGAT/GCTGAA 1 -- int11Minor allele frequency- G:0.02EA 120
    rs73291601,2
    C,F,H--9548333(+) CAACCT/CGCCTC 1 -- int112Minor allele frequency- C:0.21NS EA NA WA CSA 755
    rs567342351,2
    C,F--9548404(+) CCACAC/GAGTCT 1 -- int12Minor allele frequency- G:0.12NA EA 240
    rs1920247881,2
    --9548462(+) CTCCCA/GCTTCT 1 -- int10--------
    rs1821348271,2
    --9548528(+) CTGCCA/GGCTCC 1 -- int10--------
    rs764026391,2
    F--9548586(+) GCTGCA/TTCCTC 1 -- int11Minor allele frequency- T:0.05WA 118
    rs1868196951,2
    --9548591(+) ATCCTC/TACAAC 1 -- int10--------
    rs1916193751,2
    --9548727(+) ACCACA/GCTCTA 1 -- int10--------
    rs1115506631,2
    F--9548847(+) TTTTCG/CTTTTC 1 -- int12Minor allele frequency- C:0.33CSA 3
    rs1417078121,2
    C--9548887(+) AAGCAC/TGCACT 1 -- int10--------
    rs798781511,2
    C,F--9549024(+) TAAACT/GTTTTA 1 -- int11Minor allele frequency- G:0.06WA 118
    rs1462757041,2
    C--9549077(+) CCCAGA/GCTGGA 1 -- int10--------
    rs1120954091,2
    C,F--9549133(+) TCAAGC/TGATTC 1 -- int13Minor allele frequency- T:0.18NA CSA 124
    rs95819581,2
    C,F--9549185(+) accacC/Tgtgcc 1 -- int15Minor allele frequency- T:0.11NA WA 244
    rs1826661581,2
    --9549321(+) ACCCAA/CCCCCG 1 -- int10--------
    rs1881365141,2
    --9549329(+) CCGGCC/TTCAGT 1 -- int10--------
    rs124308811,2
    C,F,H--9549348(+) CGACTT/CGCATG 1 -- int111Minor allele frequency- C:0.25NS EA WA NA CSA 785
    rs1930766781,2
    --9549390(+) AAGATA/CTTCGA 1 -- int10--------
    rs24912421,2
    C,F,A,H--9549542(+) GGGGTG/AAGAGA 1 -- int112Minor allele frequency- A:0.50NS EA NA WA 786
    rs25042281,2
    C,F,A--9549545(+) GTGAGA/GGACAA 1 -- int19Minor allele frequency- G:0.48NA WA EA 370
    rs1391748521,2
    --9549613(+) TAGAAC/GGCCTA 1 -- int10--------
    rs1493626551,2
    C--9549666(+) GGGGTC/TGAAGG 1 -- int10--------
    rs1446704771,2
    --9549748(+) CCAGAC/TAATCT 1 -- int10--------
    rs95129791,2
    C,F,H--9549749(+) CAGACA/GATCTA 1 -- int110Minor allele frequency- G:0.09NS EA NA CSA WA 782
    rs1485416041,2
    --9549839(+) AAGCCA/GAGGCG 1 -- int10--------
    rs95819591,2
    C,A--9549943(+) TGGTGT/CACACC 1 -- int11Minor allele frequency- C:0.00NA 2
    rs1999094451,2
    --9549943(+) TGGTG-/CACACCT 1 -- int10--------
    rs25042291,2
    C,A--9549944(+) GGTGCG/ACACCT 1 -- int16Minor allele frequency- A:0.09WA NA CSA 11
    rs1409331051,2
    --9549958(+) ACCCCA/TGCTAC 1 -- int10--------
    rs1852818531,2
    --9550126(+) TGAAAC/TAGAGA 1 -- int10--------
    rs95129801,2
    C,F,A,H--9550155(+) ATGCGT/CGAGCA 1 -- int134Minor allele frequency- C:0.17NS EA NA WA CSA 3200
    rs1905249841,2
    C--9550203(+) AAAATA/GTGCCT 1 -- int10--------
    rs1931156201,2
    --9550210(+) GCCTCA/GCAGTT 1 -- int10--------
    rs1447787041,2
    --9550212(+) CTCGCA/GGTTCA 1 -- int10--------
    rs734369631,2
    C,F--9550253(+) TTTTTA/GAAACT 1 -- int13Minor allele frequency- G:0.31WA 122
    rs1513387371,2
    --9550280(+) TTAAGA/CTTATT 1 -- int10--------
    rs1405997981,2
    --9550291(+) TCATTA/GTTATT 1 -- int10--------
    rs1834910061,2
    --9550320(+) GGGCAA/GTGCTA 1 -- int10--------
    rs95819601,2
    C,F,A,H--9550323(+) cagtgG/Ctatag 1 -- int115Minor allele frequency- C:0.16NS EA WA NA CSA 783
    rs1503057451,2
    --9550380(+) ACTGGC/GATTAC 1 -- int10--------
    rs95819611,2
    F,A--9550449(+) gagacG/Agagtc 1 -- int12Minor allele frequency- A:0.50NA 4
    rs1407680691,2
    C--9550459(+) CTCACA/TCTGTC 1 -- int10--------
    rs1881754961,2
    --9550486(+) AGTGGC/TGCCAT 1 -- int10--------
    rs1115235821,2
    C--9550526(+) GTTCAC/TGCCAT 1 -- int10--------
    rs128722321,2
    C,A--9550627(+) gtgttA/Ggccag 1 -- int15Minor allele frequency- G:0.10NA WA CSA 10
    rs1839666301,2
    --9550712(+) ACCACA/GCCCGG 1 -- int10--------
    rs1897412521,2
    --9550933(+) CTCACA/GCCTGT 1 -- int10--------
    rs1816717781,2
    --9550977(+) ATTGCG/TTGAGC 1 -- int10--------
    rs1868066791,2
    --9551025(+) TCCCAA/TCTCTA 1 -- int10--------
    rs1136362931,2
    F--9551152(+) ATCACG/ACCACT 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1385608731,2
    --9551363(+) GAGAAC/GGTAAT 1 -- int10--------
    rs1417492231,2
    --9551383(+) GCAAAC/GGAGGA 1 -- int10--------
    rs1435491141,2
    C--9551410(+) AGTGGA/GCTATG 1 -- int10--------
    rs1163784251,2
    F--9551452(+) ACAGAG/CAACAG 1 -- int11Minor allele frequency- C:0.03WA 118
    rs1116865051,2
    F--9551537(+) CCAACG/AAATGG 1 -- int12