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Aliases for FLT3 Gene

Aliases for FLT3 Gene

  • Fms Related Tyrosine Kinase 3 2 3
  • Fms-Related Tyrosine Kinase 3 2 3 5
  • Stem Cell Tyrosine Kinase 1 3 4
  • Fms-Like Tyrosine Kinase 3 3 4
  • FL Cytokine Receptor 3 4
  • CD135 Antigen 3 4
  • EC 2.7.10.1 4 63
  • CD135 3 4
  • FLK-2 3 4
  • STK1 3 4
  • FLK2 3 4
  • Growth Factor Receptor Tyrosine Kinase Type III 3
  • Fetal Liver Kinase 2 3
  • Fetal Liver Kinase-2 4
  • EC 2.7.10 63
  • STK-1 4
  • FLT-3 4

External Ids for FLT3 Gene

Previous GeneCards Identifiers for FLT3 Gene

  • GC13M026557
  • GC13M022557
  • GC13M027507
  • GC13M026375
  • GC13M027475
  • GC13M028577
  • GC13M009398

Summaries for FLT3 Gene

Entrez Gene Summary for FLT3 Gene

  • This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]

GeneCards Summary for FLT3 Gene

FLT3 (Fms Related Tyrosine Kinase 3) is a Protein Coding gene. Diseases associated with FLT3 include leukemia, acute lymphoblastic and leukemia, acute myeloid. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is FGFR1.

UniProtKB/Swiss-Prot for FLT3 Gene

  • Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

Tocris Summary for FLT3 Gene

  • FMS-like receptor tyrosine kinase-3 (FLT3) is a member of the class III RTK (receptor tyrosine kinase) family and is expressed primarily in hematopoietic progenitor cells. Its expression in these cells means that FLT3 has an important role in the pathogenesis of AML.

Gene Wiki entry for FLT3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLT3 Gene

Genomics for FLT3 Gene

Regulatory Elements for FLT3 Gene

Promoters for FLT3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FLT3 on UCSC Golden Path with GeneCards custom track

Genomic Location for FLT3 Gene

Chromosome:
13
Start:
28,003,274 bp from pter
End:
28,100,592 bp from pter
Size:
97,319 bases
Orientation:
Minus strand

Genomic View for FLT3 Gene

Genes around FLT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FLT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FLT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FLT3 Gene

Proteins for FLT3 Gene

  • Protein details for FLT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36888-FLT3_HUMAN
    Recommended name:
    Receptor-type tyrosine-protein kinase FLT3
    Protein Accession:
    P36888
    Secondary Accessions:
    • A0AVG9
    • B7ZLT7
    • B7ZLT8
    • F5H0A0
    • Q13414

    Protein attributes for FLT3 Gene

    Size:
    993 amino acids
    Molecular mass:
    112903 Da
    Quaternary structure:
    • Monomer in the absence of bound FLT3LG. Homodimer in the presence of bound FLT3LG. Interacts with FIZ1 following ligand activation (By similarity). Interacts with FES, FER, LYN, FGR, HCK, SRC and GRB2. Interacts with PTPRJ/DEP-1 and PTPN11/SHP2. Interacts with RNF115 and RNF126 (By similarity).
    Miscellaneous:
    • Can be used as diagnostic tool to establish the exact cause of acute myeloid leukemia, and to determine the optimal therapy.

    Three dimensional structures from OCA and Proteopedia for FLT3 Gene

    Alternative splice isoforms for FLT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FLT3 Gene

Proteomics data for FLT3 Gene at MOPED

Post-translational modifications for FLT3 Gene

  • Autophosphorylated on several tyrosine residues in response to FLT3LG binding. FLT3LG binding also increases phosphorylation of mutant kinases that are constitutively activated. Dephosphorylated by PTPRJ/DEP-1, PTPN1, PTPN6/SHP-1, and to a lesser degree by PTPN12. Dephosphorylation is important for export from the endoplasmic reticulum and location at the cell membrane.
  • N-glycosylated, contains complex N-glycans with sialic acid.
  • Rapidly ubiquitinated by UBE2L6 and the E3 ubiquitin-protein ligase SIAH1 after autophosphorylation, leading to its proteasomal degradation.
  • Ubiquitination at Lys 614 and Lys 623
  • Glycosylation at Asn 43, Asn 100, Asn 151, Asn 306, Asn 323, Asn 351, Asn 354, Asn 473, Asn 502, and Asn 541
  • Modification sites at PhosphoSitePlus

Other Protein References for FLT3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FLT3 (FLT3)

Protein Products

Domains & Families for FLT3 Gene

Suggested Antigen Peptide Sequences for FLT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P36888

UniProtKB/Swiss-Prot:

FLT3_HUMAN :
  • The juxtamembrane autoregulatory region is important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of bound ligand. Upon tyrosine phosphorylation, it mediates interaction with the SH2 domains of numerous signaling partners. In-frame internal tandem duplications (ITDs) result in constitutive activation of the kinase. The activity of the mutant kinase can be stimulated further by FLT3LG binding.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Domain:
  • The juxtamembrane autoregulatory region is important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of bound ligand. Upon tyrosine phosphorylation, it mediates interaction with the SH2 domains of numerous signaling partners. In-frame internal tandem duplications (ITDs) result in constitutive activation of the kinase. The activity of the mutant kinase can be stimulated further by FLT3LG binding.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
genes like me logo Genes that share domains with FLT3: view

Function for FLT3 Gene

Molecular function for FLT3 Gene

GENATLAS Biochemistry:
fms-related receptor tyrosine kinase 3,expressed on endothelial cell,duplicated in childhood acute myeloid leukemia with poor prognosis and acute lymphoblastic leukemia but not in myelodysplastic syndrome
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Present in an inactive conformation in the absence of bound ligand. FLT3LG binding leads to dimerization and activation by autophosphorylation.
UniProtKB/Swiss-Prot Function:
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

Enzyme Numbers (IUBMB) for FLT3 Gene

Gene Ontology (GO) - Molecular Function for FLT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity IEA --
GO:0042803 protein homodimerization activity TAS 19549778
genes like me logo Genes that share ontologies with FLT3: view
genes like me logo Genes that share phenotypes with FLT3: view

Human Phenotype Ontology for FLT3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FLT3 Gene

MGI Knock Outs for FLT3:

Animal Model Products

miRNA for FLT3 Gene

miRTarBase miRNAs that target FLT3

No data available for Transcription Factor Targets and HOMER Transcription for FLT3 Gene

Localization for FLT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLT3 Gene

Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen. Note=Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FLT3 Gene COMPARTMENTS Subcellular localization image for FLT3 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
cytosol 3
extracellular 3
nucleus 3
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FLT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with FLT3: view

Pathways & Interactions for FLT3 Gene

genes like me logo Genes that share pathways with FLT3: view

SIGNOR curated interactions for FLT3 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for FLT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001776 leukocyte homeostasis ISS --
GO:0002318 myeloid progenitor cell differentiation ISS --
GO:0002328 pro-B cell differentiation ISS --
GO:0006468 protein phosphorylation IEA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA,TAS 7507245
genes like me logo Genes that share ontologies with FLT3: view

Drugs & Compounds for FLT3 Gene

(81) Drugs for FLT3 Gene - From: DGIdb, Novoseek, HMDB, Tocris, ClinicalTrials, ApexBio, DrugBank, IUPHAR, FDA Approved Drugs, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sunitinib Approved, Investigational Pharma inhibitor, Target, multitarget VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor, RTK inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors, Potent VEGFR, PDGFRbeta and KIT inhibitor 486
Sorafenib Approved, Investigational Pharma inhibitors, inhibitor, Target, antagonist Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 671
Azacitidine Approved, Investigational Pharma inhibitor 360
ponatinib Approved Pharma inhibitor, Target Kinase Inhibitors, Fibroblast growth factor receptor (FGFR)inhibitors 29
Cytarabine Approved, Investigational Pharma 1035

(24) Additional Compounds for FLT3 Gene - From: HMDB, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
5'-Fluoroindirubinoxime
861214-33-7
AC 710
1351522-04-7
genes like me logo Genes that share compounds with FLT3: view

Drug Products

Transcripts for FLT3 Gene

mRNA/cDNA for FLT3 Gene

Unigene Clusters for FLT3 Gene

Fms-related tyrosine kinase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FLT3 Gene

No ASD Table

Relevant External Links for FLT3 Gene

GeneLoc Exon Structure for
FLT3
ECgene alternative splicing isoforms for
FLT3

Expression for FLT3 Gene

mRNA expression in normal human tissues for FLT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FLT3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x11.9), Brain - Cerebellum (x10.0), and Whole Blood (x8.3).

Protein differential expression in normal tissues from HIPED for FLT3 Gene

This gene is overexpressed in Brain (49.3) and Fetal gut (19.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FLT3 Gene



SOURCE GeneReport for Unigene cluster for FLT3 Gene Hs.507590

mRNA Expression by UniProt/SwissProt for FLT3 Gene

P36888-FLT3_HUMAN
Tissue specificity: Detected in bone marrow, in hematopoietic stem cells, in myeloid progenitor cells and in granulocyte/macrophage progenitor cells (at protein level). Detected in bone marrow, liver, thymus, spleen and lymph node, and at low levels in kidney and pancreas. Highly expressed in T-cell leukemia.
genes like me logo Genes that share expression patterns with FLT3: view

Protein tissue co-expression partners for FLT3 Gene

Primer Products

In Situ Assay Products

Orthologs for FLT3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FLT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FLT3 36
  • 99 (a)
OneToOne
FLT3 35
  • 99.6 (n)
  • 98.99 (a)
cow
(Bos Taurus)
Mammalia FLT3 36
  • 90 (a)
OneToOne
FLT3 35
  • 88.27 (n)
  • 90.64 (a)
dog
(Canis familiaris)
Mammalia FLT3 36
  • 90 (a)
OneToOne
FLT3 35
  • 90.74 (n)
  • 91.84 (a)
mouse
(Mus musculus)
Mammalia Flt3 16
Flt3 36
  • 85 (a)
OneToOne
Flt3 35
  • 83.15 (n)
  • 86.18 (a)
oppossum
(Monodelphis domestica)
Mammalia FLT3 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FLT3 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Flt3 35
  • 82.31 (n)
  • 84.53 (a)
chicken
(Gallus gallus)
Aves FLT3 35
  • 65.12 (n)
  • 57.13 (a)
FLT3 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FLT3 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia flt3 35
  • 59.73 (n)
  • 51.99 (a)
zebrafish
(Danio rerio)
Actinopterygii flt3 35
  • 53.5 (n)
  • 45.67 (a)
flt3 36
  • 35 (a)
OneToOne
Species with no ortholog for FLT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FLT3 Gene

ENSEMBL:
Gene Tree for FLT3 (if available)
TreeFam:
Gene Tree for FLT3 (if available)

Paralogs for FLT3 Gene

(16) SIMAP similar genes for FLT3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FLT3: view

Variants for FLT3 Gene

Sequence variations from dbSNP and Humsavar for FLT3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs12872889 - 28,100,491(+) CGCCG(C/T)CGCGC nc-transcript-variant, reference, missense
rs1933437 - 28,050,157(-) TGGGA(C/T)GGACA nc-transcript-variant, reference, missense
rs56321896 - 28,057,358(+) TACTC(A/G)CTGTA nc-transcript-variant, reference, missense, splice-donor-variant, utr-variant-5-prime
rs35602083 - 28,049,450(+) GGTGT(C/T)GTTTC nc-transcript-variant, reference, missense
rs34172843 - 28,048,407(+) CATAA(A/T)CTTCA nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FLT3 Gene

Variant ID Type Subtype PubMed ID
esv275421 CNV Loss 21479260
esv1336289 CNV Insertion 17803354
nsv973 CNV Insertion 18451855
esv34052 CNV Loss 18971310
esv269085 CNV Insertion 20981092
esv2677792 CNV Deletion 23128226
nsv826599 CNV Loss 20364138
esv2674990 CNV Deletion 23128226

Variation tolerance for FLT3 Gene

Residual Variation Intolerance Score: 59.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.22; 92.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FLT3 Gene

HapMap Linkage Disequilibrium report
FLT3
Human Gene Mutation Database (HGMD)
FLT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLT3 Gene

Disorders for FLT3 Gene

MalaCards: The human disease database

(38) MalaCards diseases for FLT3 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
leukemia, acute lymphoblastic
  • leukemia, t-cell acute lymphocytic, somatic
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
minimally differentiated acute myeloblastic leukemia
  • aml m0
acute biphenotypic leukemia
acute myeloblastic leukemia without maturation
  • acute myeloblastic leukemia m1
- elite association - COSMIC cancer census association via MalaCards
Search FLT3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FLT3_HUMAN
  • Leukemia, acute myelogenous (AML) [MIM:601626]: A subtype of acute leukemia, a cancer of the white blood cells. AML is a malignant disease of bone marrow characterized by maturational arrest of hematopoietic precursors at an early stage of development. Clonal expansion of myeloid blasts occurs in bone marrow, blood, and other tissue. Myelogenous leukemias develop from changes in cells that normally produce neutrophils, basophils, eosinophils and monocytes. {ECO:0000269 PubMed:11090077, ECO:0000269 PubMed:11290608, ECO:0000269 PubMed:11442493, ECO:0000269 PubMed:14504097, ECO:0000269 PubMed:16266983, ECO:0000269 PubMed:18305215, ECO:0000269 PubMed:8946930, ECO:0000269 PubMed:9737679}. Note=The gene represented in this entry may be involved in disease pathogenesis. Somatic mutations that lead to constitutive activation of FLT3 are frequent in AML patients. These mutations fall into two classes, the most common being in-frame internal tandem duplications of variable length in the juxtamembrane region that disrupt the normal regulation of the kinase activity. Likewise, point mutations in the activation loop of the kinase domain can result in a constitutively activated kinase.

Relevant External Links for FLT3

Genetic Association Database (GAD)
FLT3
Human Genome Epidemiology (HuGE) Navigator
FLT3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FLT3
genes like me logo Genes that share disorders with FLT3: view

No data available for Genatlas for FLT3 Gene

Publications for FLT3 Gene

  1. The ability of sorafenib to inhibit oncogenic PDGFRbeta and FLT3 mutants and overcome resistance to other small molecule inhibitors. (PMID: 17229632) Lierman E. … Cools J. (Haematologica 2007) 3 23 25 26
  2. An innovative phase I clinical study demonstrates inhibition of FLT3 phosphorylation by SU11248 in acute myeloid leukemia patients. (PMID: 14654525) O'Farrell A.M. … Cherrington J.M. (Clin. Cancer Res. 2003) 3 23 25 26
  3. Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells. (PMID: 8394751) Rosnet O. … Birnbaum D. (Blood 1993) 2 3 4 67
  4. Antitumor activity of sorafenib in FLT3-driven leukemic cells. (PMID: 17205056) Auclair D. … Wilhelm S.M. (Leukemia 2007) 23 25 26
  5. Flt3 receptor tyrosine kinase as a drug target in leukemia. (PMID: 15180525) Schmidt-Arras D. … Serve H. (Curr. Pharm. Des. 2004) 23 25 26

Products for FLT3 Gene

Sources for FLT3 Gene

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