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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FLT3 Gene

protein-coding   GIFtS: 71
GCID: GC13M028577

fms-related tyrosine kinase 3
 Explore 66 diseases affiliated with
FLT3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FLT3    

Aliases
for FLT3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Fms-Related Tyrosine Kinase 31 2     FL Cytokine Receptor2 3
CD1351 2 3     EC 2.7.10.13 8
FLK21 2 3     Fetal Liver Kinase 22
STK11 2 3     Growth Factor Receptor Tyrosine Kinase Type III2
Fms-Like Tyrosine Kinase 32 3     Receptor-Type Tyrosine-Protein Kinase FLT32
Stem Cell Tyrosine Kinase 12 3     FLT-33
FLK-22 3     Fetal Liver Kinase-23
STK-12 3     EC 2.7.108
CD135 Antigen2 3     

External Ids:    HGNC: 37651   Entrez Gene: 23222   Ensembl: ENSG000001220257   OMIM: 1363515   UniProtKB: P368883   

Export aliases for FLT3 gene to outside databases

Previous GC identifers: GC13M026557 GC13M022557 GC13M027507 GC13M026375 GC13M027475 GC13M009398


Summaries
for FLT3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FLT3:
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an
extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase
domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related
tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading
to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates
multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of
hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in
acute myeloid leukemia and acute lymphoblastic leukemia. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FLT3_HUMAN, P36888
Function: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates
differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes
phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling
and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES,
FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal
activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and
resistance to apoptosis via the activation of multiple signaling pathways

Gene Wiki entry for FLT3 (CD135)


Genomic Views
for FLT3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FLT3 gene promoter:
         STAT5B   Pax-5   AP-1   ATF-2   GATA-2   C/EBPalpha   STAT3   c-Jun   NF-kappaB1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FLT3 promoter sequence
   Search SABiosciences Chromatin IP Primers for FLT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FLT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12   Ensembl cytogenetic band:  13q12.2   HGNC cytogenetic band: 13q12

FLT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FLT3 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M028577:  view genomic region     (about GC identifiers)

Start:
 28,577,411 bp from pter      End:
 28,674,729 bp from pter
Size:
 97,319 bases      Orientation:
 minus strand

Proteins
for FLT3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FLT3_HUMAN, P36888 (See protein sequence)
Recommended Name: Receptor-type tyrosine-protein kinase FLT3 precursor  
Size: 993 amino acids; 112903 Da
Subunit: Monomer in the absence of bound FLT3LG. Homodimer in the presence of bound FLT3LG. Interacts with FIZ1
following ligand activation (By similarity). Interacts with FES, FER, LYN, FGR, HCK, SRC and GRB2. Interacts with
PTPRJ/DEP-1 and PTPN11/SHP2
Subcellular location: Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen. Note=Constitutively
activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a
significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is
rapidly targeted for degradation
Miscellaneous: Can be used as diagnostic tool to establish the exact cause of acute myeloid leukemia, and to determine
the optimal therapy
3 PDB 3D structures from and Proteopedia for FLT3:
1RJB (3D)        3QS7 (3D)        3QS9 (3D)    
Secondary accessions: A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414
Alternative splicing: 2 isoforms:  P36888-1   P36888-2   

Explore the universe of human proteins at neXtProt for FLT3: NX_P36888

Post-translational modifications:

  • N-glycosylated, contains complex N-glycans with sialic acid1
  • Autophosphorylated on several tyrosine residues in response to FLT3LG binding. FLT3LG binding also increases
    • phosphorylation of mutant kinases that are constitutively activated. Dephosphorylated by PTPRJ/DEP-1, PTPN1,
    PTPN6/SHP-1, and to a lesser degree by PTPN12. Dephosphorylation is important for export from the endoplasmic
    reticulum and location at the cell membrane1
  • Rapidly ubiquitinated by UBE2L6 and the E3 ubiquitin-protein ligase SIAH1 after autophosphorylation, leading to its
    • proteasomal degradation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P36888

    • 4/13 DME Specific Peptides for FLT3 (P36888) (see all 13)
     VAVKMLK  RDLAARN  ALMSELK  WEIFSLG 

    FLT3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004110.2  
    ENSEMBL proteins: 
     ENSP00000241453   ENSP00000370374   ENSP00000370369   ENSP00000438139  

    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant FLT3 Protein
    R&D Systems Recombinant & Natural Proteins for FLT3 (Flt-3/Flk-2)
    Enzo Life Sciences proteins for FLT3
    OriGene Purified Protein: FLT3
    OriGene Protein Over-expression Lysate: FLT3
    OriGene Custom Protein Services for FLT3 
    GenScript Purified and Recombinant Proteins for FLT3
    Novus Biologicals FLT3 Proteins
    Novus Biologicals FLT3 Lysate
    Sino Biological Recombinant Protein for FLT3
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view) (see first 5):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005788endoplasmic reticulum lumen IEA--
    GO:0005887integral to plasma membrane TAS8394751
    GO:0009986cell surface IEA--
    GO:0016020membrane ----
    GO:0016021integral to membrane ----


    FLT3 for ontologies           About GeneDecksing



    FLT3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of FLT3
    R&D Systems Antibodies for FLT3 (Flt-3/Flk-2)
    Cell Signaling Technology (CST) Antibodies for FLT3 
    OriGene Antibodies: FLT3
    OriGene Custom Antibody Services for FLT3 
    GenScript Custom Superior Antibodies Services for FLT3
    Novus Biologicals FLT3 Antibodies
    Abcam antibodies for FLT3 
    Browse Antibodies at Uscn
    ThermoFisher Antibody for FLT3

    Assay Products for FLT3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for FLT3 (Flt-3/Flk-2)         (see all)
    GenScript FLT3-Activity-based Kinase Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for FLT3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for FLT3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FLT3 for domains           About GeneDecksing

    5/12 InterPro domains/families (see all 12):
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold
     IPR000719 Prot_kinase_cat_dom
     IPR001824 Tyr_kinase_rcpt_3_CS

    Graphical View of Domain Structure for InterPro Entry P36888

    ProtoNet protein and cluster: P36888

    2 Blocks protein families:
    IPB003599 Immunoglobulin subtype
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: FLT3_HUMAN, P36888
    Domain: The juxtamembrane autoregulatory region is important for normal regulation of the kinase activity and for
    maintaining the kinase in an inactive state in the absence of bound ligand. Upon tyrosine phosphorylation, it mediates
    interaction with the SH2 domains of numerous signaling partners. In-frame internal tandem duplications (ITDs) result
    in constitutive activation of the kinase. The activity of the mutant kinase can be stimulated further by FLT3LG
    binding
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 protein kinase domain


    Function
    for FLT3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FLT3_HUMAN, P36888
    Function: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates
    differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes
    phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling
    and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES,
    FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal
    activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and
    resistance to apoptosis via the activation of multiple signaling pathways
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Present in an inactive conformation in the absence of bound ligand. FLT3LG binding leads to
    dimerization and activation by autophosphorylation

         Genatlas biochemistry entry for FLT3:
    fms-related receptor tyrosine kinase 3,expressed on endothelial cell,duplicated in childhood acute myeloid leukemia
    with poor prognosis and acute lymphoblastic leukemia but not in myelodysplastic syndrome

    Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

    miRNA
    Products:            		 OriGene 3'-UTR Clone: FLT3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FLT3
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate FLT3 (see all 33):
    hsa-miR-3194-5p hsa-miR-15a hsa-miR-1245 hsa-miR-139-5p hsa-miR-3074-3p hsa-miR-570 hsa-miR-3142 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: FLT3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FLT3 (see all 4)
    OriGene shRNA RFP: FLT3
    OriGene siRNA: FLT3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FLT3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for FLT3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FLT3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FLT3 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: FLT3 (NM_004119)
    Sino Biological Human cDNA Clone for FLT3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FLT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLT3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for FLT3
    Search LifeMap BioReagents cell lines for FLT3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLT3

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004713protein tyrosine kinase activity ----
    GO:0004714transmembrane receptor protein tyrosine kinase activity TAS19549778
    GO:0004896cytokine receptor activity ISS--
    GO:0005021vascular endothelial growth factor-activated receptor activity TAS8394751
    GO:0005515protein binding IPI--


    FLT3 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for FLT3:
     Decreased substrate adherent c  Decreased viability 

    Animal Models:
         Mouse knock-out Flt3tm1Irl for FLT3
         7 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Flt3):
     cellular  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  tumorigenesis 

    FLT3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FLT3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    		P2Y Receptor Signaling0.38
    2Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    3Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency1.00
    		14-3-3 Induced Intracellular Signaling0.59
    		GSK3 Signaling0.61
    		eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    		Actin Nucleation by ARP-WASP Complex1.00
    		CDC42 Pathway0.34
    		Actin Nucleation and Branching0.66
    5Akt Signaling
    		Akt Signaling1.00
    		p38 Signaling0.60

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for FLT3
        Development Flt3 signaling

    5/29 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FLT3 (see all 29)
        FLT3 Signaling
    MAPK Signaling
    Paxillin Interactions
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer

    1 Cell Signaling Technology (CST) Pathway for FLT3
        Tyrosine Kinases / Adaptors

    1 GeneGo (Thomson Reuters) Pathway for FLT3
        Development Flt3 signaling

    1 PharmGKB Pathway for FLT3
        Sorafenib Pharmacodynamics

    4         Kegg Pathways  (Kegg details for FLT3):
        Cytokine-cytokine receptor interaction
    Hematopoietic cell lineage
    Pathways in cancer
    Acute myeloid leukemia


    FLT3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FLT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/32 Interacting proteins for FLT3 (P368881, 2, 3 ENSP000002414534) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279862, 3, ENSP000002743354MINT-7103574 MINT-7103585 I2D: score=2 STRING: ENSP00000274335
    PTPN11Q061242, 3, ENSP000003409444MINT-8030324 MINT-8030340 I2D: score=1 STRING: ENSP00000340944
    IKBKGQ9Y6K91, 3, ENSP000003586224EBI-3946257,EBI-356130 I2D: score=1 STRING: ENSP00000358622
    SOCS1O155243, ENSP000003294184I2D: score=4 STRING: ENSP00000329418
    INPP5DQ928353, ENSP000003525754I2D: score=3 STRING: ENSP00000352575
    About this table

    Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001776leukocyte homeostasis ISS--
    GO:0002318myeloid progenitor cell differentiation ISS--
    GO:0002320lymphoid progenitor cell differentiation ----
    GO:0002328pro-B cell differentiation ISS--
    GO:0002572pro-T cell differentiation IEA--


    FLT3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FLT3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FLT3 for compounds           About GeneDecksing

    EMD Millipore small molecules for FLT3:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for FLT3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SU 5416 VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3 [204005-46-9]
    Lestaurtinib JAK2, FLT3 and TrkA inhibitor [111358-88-4]
    TCS 359Potent FLT3 inhibitor[301305-73-7]

    2 HMDB Compounds for FLT3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    2 DrugBank Compounds for FLT3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    SunitinibSU11248 (see all 3)557795-19-4targetmultitarget14654525 12531805 15304385 15180525 11752352 14753710
    Sorafenib-- 284461-73-0targetantagonist17229632 17205056

    10/40 Novoseek chemical compound relationships for FLT3 gene (see all 40)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pkc 412 91.7 85 17330105 (5), 18071308 (5), 15956279 (4), 15150124 (4) (see all 27)
    lestaurtinib 88.1 22 16868253 (4), 16857985 (2), 20141349 (2), 18341639 (2) (see all 7)
    tyrosine 85.3 556 17851558 (7), 15345597 (4), 9737679 (3), 14726387 (3) (see all 99)
    tandutinib 84.9 24 16902153 (4), 15256420 (3), 15242881 (3), 19625780 (3) (see all 6)
    ag-1296 80.8 21 11455967 (7), 12357354 (2), 17050201 (2), 18509353 (2) (see all 6)
    sunitinib 74.2 28 17889720 (4), 17041096 (3), 17591828 (1), 18192256 (1) (see all 20)
    daniplestim 67.8 1 10781904 (1)
    imatinib 67.8 30 18797870 (3), 14976243 (2), 15180525 (2), 11290609 (1) (see all 13)
    sorafenib 67.5 37 17229632 (6), 18230792 (4), 17889720 (4), 17205056 (2) (see all 20)
    su5416 62.1 11 15158089 (5), 12351406 (2), 17169805 (1), 12649163 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about FLT3 

    Transcripts
    for FLT3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FLT3 gene: 
    NM_004119.2  

    Unigene Cluster for FLT3:

    Fms-related tyrosine kinase 3
    Hs.507590  [show with all ESTs]
    Unigene Representative Sequence: NM_004119
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000241453(uc001urw.3 uc010aao.3 uc010tdn.2) ENST00000380987
    ENST00000469894 ENST00000380982 ENST00000537084

    miRNA
    Products:             		 OriGene 3'-UTR Clone: FLT3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FLT3
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate FLT3 (see all 33):
    hsa-miR-3194-5p hsa-miR-15a hsa-miR-1245 hsa-miR-139-5p hsa-miR-3074-3p hsa-miR-570 hsa-miR-3142 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: FLT3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FLT3 (see all 4)
    OriGene shRNA RFP: FLT3
    OriGene siRNA: FLT3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FLT3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FLT3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FLT3 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: FLT3 (NM_004119)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FLT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLT3 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FLT3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FLT3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FLT3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FLT3

    Additional cDNA sequence: 

    BC126350.1 BC144039.1 BC144040.1 L36162.1 U02687.1 Z26652.1 

    4 DOTS entries:

    DT.120782229  DT.104253  DT.75174632  DT.91675080 

    17 AceView cDNA sequences:

    BX279530 BU681356 BC036028 BF589957 U02687 Z26652 NM_004119 AV713950 
    AW772610 AW059681 L36162 AW057705 AI150354 BI461248 BF170536 BF176247 
    BF170584 

    GeneLoc Exon Structure


    Expression
    for FLT3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FLT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGTGATTCCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FLT3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BloodPeripheral BloodCommon Lymphoid Progenitor CellsBlood
    BloodPeripheral BloodImmature B CellsBlood
    BloodPeripheral BloodPre-B CellsBlood
    BloodPeripheral BloodB-cell Progenitor CellsBlood
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See FLT3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FLT3

    SOURCE GeneReport for Unigene cluster: Hs.507590

    UniProtKB/Swiss-Prot: FLT3_HUMAN, P36888
    Tissue specificity: Detected in bone marrow, in hematopoietic stem cells, in myeloid progenitor cells and in
    granulocyte/macrophage progenitor cells (at protein level). Detected in bone marrow, liver, thymus, spleen and lymph
    node, and at low levels in kidney and pancreas. Highly expressed in T-cell leukemia

        SABiosciences Expression via Pathway-Focused PCR Arrays including FLT3: 
              Antigen Presenting Cells in human mouse rat
              Lymphoma in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FLT3
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    In Situ
    Assay Products:     
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    Orthologs
    for FLT3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FLT3 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC1008584221 receptor-type tyrosine-protein kinase FLT3-like 65.05(n)
    57.81(a)    		   100858422  XM_003640612.1  XP_003640660.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    FLT36
    		 --
    		 87(a)
    22(a)
    		 1 ↔ many
    1 ↔ many
    		 3(185927794-185934882)
    3(185896159-185924109)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5667081 FL cytokine receptor-like 56.82(n)
    50.42(a)    		   566708  XM_001921725.1  XP_001921760.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Pvr6
    		 PDGF- and VEGF-receptor related
    		 12(a)
    		 1 → many
    		 2L(8220980-8239878)


    ENSEMBL Gene Tree for FLT3 (if available)
    TreeFam Gene Tree for FLT3 (if available) 

    Paralogs
    for FLT3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FLT3 gene
    FLT42  FGFR42  PDGFRB2  CSF1R2  FGFR32  KIT2  PDGFRA2  RET2  
    KDR2  FGFR12  FGFR22  FLT12  
    17 SIMAP similar genes for FLT3 using alignment to 3 protein entries:     FLT3_HUMAN (see all proteins):
    STK-1    RET    NIN/PDGFRB fusion    ABL1    KIT    FES
    CSF1R    FGR    urf-ret    EPHA2    DKFZp686M05208    CDK4
    FGFR2    tec    PDGFRA    TIE1    FGFR3

    FLT3 for paralogs           About GeneDecksing



    Genomic Variants
    for FLT3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2097 NCBI SNPs in FLT3 are shown (see all 2097)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1219134881,2
    		Cprobable-pathogenic28592642(-) CTCGAA/C/G/T 
                ATATC     		4 N H D Y mis10--------
    rs1219096461,2
    		Cother28592641(-) TCGAGA/TTATCA 2 D V mis10--------
    rs670344461,2
    		C--9411616(+) TTCTCT/-TTTTT 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1816549321,2
    		--28576916(+) GTTCCA/GGATCC 1 -- ds50010--------
    rs1870561381,2
    		--28576941(+) CTACAC/TGCAAC 1 -- ds50010--------
    rs19993651,2
    		H--28576964(-) CTCTTC/TTTTCT 1 -- ds50014Minor allele frequency- T:0.00NS EA 398
    rs740415251,2
    		C,--28576995(+) TCGTGT/AAAGCG 1 -- ds50012Minor allele frequency- A:0.05WA 120
    rs19993641,2
    		C,F,A,H,--28577035(-) GGCTTA/C/GTGAAC 1 -- ds500130NS EA NA WA 2970
    rs1388492321,2
    		--28577088(+) GGTCGC/TCATGG 1 -- ds50010--------
    rs1420271851,2
    		--28577433(+) CTTTAC/TTGAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FLT3 (28577411 - 28674729 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for FLT3
         1 CNV: 47983
    Human Gene Mutation Database (HGMD): FLT3

    5/20 SABiosciences Cancer Mutation PCR Assays for FLT3 (see all 20):
    Cosmic IdAA Change
    27979p.E596_Y597ins12
    783p.D835Y
    28047p.R834Q
    19522p.V592A
    24531p.M837P
    5/9 SABiosciences Cancer Mutation PCR Arrays containing FLT3 (see all 9):
    Hematopoietic Neoplasms
    FLT3 Pathway
    Cancer Comprehensive Panel 384HT
    Oncogene Panel 384HT
    Receptor Tyrosine Kinase (RTK) (Panel I)
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FLT3
    DNA2.0 Custom Variant and Variant Library Synthesis for FLT3

    Disorders / Diseases
    for FLT3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FLT3 for disorders           About GeneDecksing

    OMIM gene information: 136351   
    OMIM disorders: 601626  
    UniProtKB/Swiss-Prot: FLT3_HUMAN, P36888
  • Defects in FLT3 are a cause of acute myelogenous leukemia (AML) [MIM:601626]. AML is a malignant disease in
    • which hematopoietic precursors are arrested in an early stage of development. Note=Somatic mutations that lead to
    constitutive activation of FLT3 are frequent in AML patients. These mutations fall into two classes, the most common
    being in-frame internal tandem duplications of variable length in the juxtamembrane region that disrupt the normal
    regulation of the kinase activity. Likewise, point mutations in the activation loop of the kinase domain can result in
    a constitutively activated kinase

    20/66 diseases for FLT3 (see all 66):    About MalaCards
    acute lymphoblastic leukemia    acute myeloid leukemia    lymphoblastic leukemia    myeloid leukemia
    leukemia, acute myeloid, reduced survival in    leukemia    hematopoiesis    juvenile myelomonocytic leukemia
    severe combined immunodeficiency    polycythemia vera    gastrointestinal stromal tumor    myelomonocytic leukemia
    bone marrow cancer    chronic myeloproliferative disease    non-hodgkin lymphoma    combined immunodeficiency
    renal cell carcinoma    megakaryoblastic leukemia    myeloproliferative disorder    stem cell leukemia

    2 diseases from the University of Copenhagen DISEASES database for FLT3:
    Leukemia     Bone marrow cancer

    10/73 Novoseek disease relationships for FLT3 gene (see all 73)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aml adult 85.2 22 12750701 (2), 15054042 (1), 15996732 (1), 10764154 (1) (see all 19)
    leukemogenesis 81.6 32 17485549 (2), 12239147 (2), 14562119 (2), 10505320 (2) (see all 20)
    aml childhood 80.8 29 15166029 (4), 20514303 (3), 15010072 (2), 17763464 (2) (see all 16)
    leukemia 79.8 215 19541823 (6), 17330105 (5), 17332306 (5), 14555522 (4) (see all 99)
    acute leukemia 73.4 56 17584026 (4), 15778081 (3), 17387224 (2), 18925699 (2) (see all 37)
    lymphoblastic leukemia acute 68.2 35 16234090 (2), 18024407 (2), 19968062 (2), 12176867 (1) (see all 28)
    leukemia promyelocytic acute 67.7 26 16105978 (2), 19176014 (2), 17939400 (2), 20096459 (2) (see all 18)
    myelodysplastic syndromes 67.6 27 16902153 (2), 15036894 (2), 16787503 (2), 15257941 (2) (see all 23)
    minimal residual disease 64 12 12239147 (3), 15645287 (2), 19176010 (1), 12854887 (1) (see all 6)
    myeloproliferative disorders 63.8 8 16761019 (2), 16557239 (1), 16938665 (1), 17076649 (1) (see all 7)

    Genetic Association Database (GAD): FLT3
    Human Genome Epidemiology (HuGE) Navigator: FLT3 (128 documents)

    Export disorders for FLT3 gene to outside databases

    Publications
    for FLT3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FLT3 gene, integrated from 9 sources (see all 1029):
    (articles sorted by number of sources associating them with FLT3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells. (PubMed id 8394751)1, 2, 3, 9 Rosnet O.... Birnbaum D. (1993)
    2. Mutations of the FLT3 gene in adult acute myeloid leukemia: determination of incidence and identification of a novel mutation in a Thai population. (PubMed id 16213360)1, 4, 9 Auewarakul C.U....Yenchitsomanus P.T. (2005)
    3. An innovative phase I clinical study demonstrates inhibition of FLT3 phosphorylation by SU11248 in acute myeloid leukemia patients. (PubMed id 14654525)1, 7, 9 O'Farrell A.M....Cherrington J.M. (2003)
    4. Structural and functional alterations of FLT3 in acut e myeloid leukemia. (PubMed id 19549778)1, 2, 9 Meshinchi S. and Appelbaum F.R. (2009)
    5. Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/macrophage progenitor stages to maintain cell survival. (PubMed id 18490735)1, 2, 9 Kikushige Y....Akashi K. (2008)
    6. Detection of FLT3 gene and FLT3/ITD mutation by polymerase chain reaction-single-strand conformation polymorphism in patients with acute lymphoblastic leukemia. (PubMed id 16234090)1, 4, 9 Xu B....Zhou S.Y. (2005)
    7. Clinical impact of internal tandem duplications and activating point mutations in FLT3 in acute myeloid leukemia in elderly patients. (PubMed id 15059064)1, 4, 9 Andersson A....Fioretos T. (2004)
    8. Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. (PubMed id 8946930)1, 2, 9 Nakao M....Misawa S. (1996)
    9. STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells. (PubMed id 7507245)1, 2, 9 Small D.... Civin C.I. (1994)
    10. The ability of sorafenib to inhibit oncogenic PDGFRbeta and FLT3 mutants and overcome resistance to other small molecule inhibitors. (PubMed id 17229632)1, 7, 9 Lierman E....Cools J. (2007)

    External Searches for FLT3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FLT3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2322 HGNC: 3765 AceView: FLT3 Ensembl:ENSG00000122025 euGenes: HUgn2322
    ECgene: FLT3 Kegg: 2322 H-InvDB: FLT3

    Other Databases showing FLT3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FLT3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FLT3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FLT3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for FLT3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FLT3 gene:
    Search GeneIP for patents involving FLT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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