Aliases for FLT3 Gene
Aliases for FLT3 Gene
External Ids for FLT3 Gene
- HGNC: 3765
- Entrez Gene: 2322
- Ensembl: ENSG00000122025
- OMIM: 136351
- UniProtKB: P36888
Previous GeneCards Identifiers for FLT3 Gene
- GC13M026557
- GC13M022557
- GC13M027507
- GC13M026375
- GC13M027475
- GC13M028577
- GC13M009398
Summaries for FLT3 Gene
-
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]
-
FLT3 is an important cytokine receptor involved in normal hematopoiesis. Mutations in this gene are common in acute myeloid leukemia (AML) and screening for mutations in this gene has been recommended by the World Health Organization in patients with AML, particularly in cases of cytogenetically normal AML (CN-AML). FLT3 mutations commonly co-occur with mutations such as NPM1 that are associated with CN-AML and likely modulate prognostic impact. While FLT3-ITD mutations have been associated with poorer prognosis in AML, the prognostic impact of FLT3-TKD mutations are still up for debate.
GeneCards Summary for FLT3 Gene
FLT3 (Fms Related Tyrosine Kinase 3) is a Protein Coding gene. Diseases associated with FLT3 include Leukemia, Acute Myeloid and Acute Myeloid Leukemia With Minimal Differentiation. Among its related pathways are Cytokine Signaling in Immune system and ERK Signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is CSF1R.
UniProtKB/Swiss-Prot for FLT3 Gene
-
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
-
FMS-like receptor tyrosine kinase-3 (FLT3) is a member of the class III RTK (receptor tyrosine kinase) family and is expressed primarily in hematopoietic progenitor cells. Its expression in these cells means that FLT3 has an important role in the pathogenesis of AML.
Additional gene information for FLT3 Gene
- Monarch Initiative
- Search for FLT3 at DataMed
- Search for FLT3 at HumanCyc
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLT3 Gene
Genomics for FLT3 Gene
GeneHancer (GH) Regulatory Elements for FLT3 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH13I028099 | Promoter/Enhancer | 1.5 | EPDnew Ensembl ENCODE | 550.8 | +0.2 | 248 | 1.8 | INSM2 KLF17 MZF1 SIN3A ZNF2 ZNF335 ZNF213 ZNF366 RUNX3 ZNF398 | FLT3 PAN3-AS1 KATNBL1P1 | |
GH13I028098 | Enhancer | 0.4 | FANTOM5 | 567.4 | +1.7 | 1675 | 0.2 | RNF2 ZNF133 EZH2 | FLT3 KATNBL1P1 | |
GH13I028102 | Enhancer | 0.4 | Ensembl | 550.8 | -1.5 | -1509 | 0.2 | HLF EZH2 | FLT3 CHCHD2P8 | |
GH13I028031 | Enhancer | 0.9 | Ensembl ENCODE | 30.4 | +68.8 | 68831 | 1 | HDGF BACH1 MAX BMI1 POLR2A ATF7 ETV6 IKZF2 RUNX3 ZNF687 | FLT3 PAN3 KATNBL1P1 PIR32072 | |
GH13I028046 | Enhancer | 1.2 | FANTOM5 Ensembl ENCODE | 12.9 | +51.7 | 51700 | 4.5 | PKNOX1 BMI1 BATF IRF4 ATF7 ETV6 FOS BCLAF1 IKZF2 RUNX3 | FLT3 KATNBL1P1 PIR32072 |
- Top Transcription factor binding sites by QIAGEN in the FLT3 gene promoter:
Regulatory Element Products
Genomic Locations for FLT3 Gene
- chr13:28,003,274-28,100,592
- (GRCh38/hg38)
- Size:
- 97,319 bases
- Orientation:
- Minus strand
- chr13:28,577,411-28,674,729
- (GRCh37/hg19)
Genomic View for FLT3 Gene
- Cytogenetic band:
-
- 13q12.2 by Ensembl
- 13q12.2 by Entrez Gene
- 13q12.2 by HGNC


RefSeq DNA sequence for FLT3 Gene
Proteins for FLT3 Gene
-
Protein details for FLT3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P36888-FLT3_HUMAN
- Recommended name:
- Receptor-type tyrosine-protein kinase FLT3
- Protein Accession:
- P36888
- A0AVG9
- B7ZLT7
- B7ZLT8
- F5H0A0
- Q13414
Protein attributes for FLT3 Gene
- Size:
- 993 amino acids
- Molecular mass:
- 112903 Da
- Quaternary structure:
-
- Monomer in the absence of bound FLT3LG. Homodimer in the presence of bound FLT3LG. Interacts with FIZ1 following ligand activation (By similarity). Interacts with FES, FER, LYN, FGR, HCK, SRC and GRB2. Interacts with PTPRJ/DEP-1 and PTPN11/SHP2. Interacts with RNF115 and RNF126 (By similarity).
- Miscellaneous:
-
- Can be used as diagnostic tool to establish the exact cause of acute myeloid leukemia, and to determine the optimal therapy.
Three dimensional structures from OCA and Proteopedia for FLT3 Gene
Protein Expression for FLT3 Gene
Selected DME Specific Peptides for FLT3 Gene
- P36888:
-
- RDLAARN
- VAVKMLK
- LPVKWMA
- NIVNLLGACT
- SDVWSYGI
- ALMSELK
- WEIFSLG
- KICDFGLARD
- AARNVLV
- EYCCYGDLLN
- GILLWEIF
- PVKWMAPE
- DFGLARDI
Post-translational modifications for FLT3 Gene
- Autophosphorylated on several tyrosine residues in response to FLT3LG binding. FLT3LG binding also increases phosphorylation of mutant kinases that are constitutively activated. Dephosphorylated by PTPRJ/DEP-1, PTPN1, PTPN6/SHP-1, and to a lesser degree by PTPN12. Dephosphorylation is important for export from the endoplasmic reticulum and location at the cell membrane.
- N-glycosylated, contains complex N-glycans with sialic acid.
- Rapidly ubiquitinated by UBE2L6 and the E3 ubiquitin-protein ligase SIAH1 after autophosphorylation, leading to its proteasomal degradation.
- Ubiquitination at posLast=614614 and Lys623
- Glycosylation at Asn43, Asn100, Asn151, Asn306, posLast=323323, Asn351, Asn354, posLast=473473, Asn502, and posLast=541541
Other Protein References for FLT3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for FLT3 (Flt-3/Flk-2)
- Cell Signaling Technology (CST) Antibodies for FLT3 (FLT3)
-
Custom Antibody ServicesOriGene Antibodies for FLT3
- Novus Biologicals Antibodies for FLT3
-
Abcam antibodies for FLT3
-
Cloud-Clone Corp. Antibodies for FLT3
- Invitrogen Antibodies for FLT3
- antibodies-online: Search results for 367 available FLT3 Antibodies ranked by validation data
- Compare Top FLT3 Antibodies
-
Recommended
- 19 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 5 IHC Antibodies (anti-human)
- 6 IF Antibodies (anti-human)
- 14 IP Antibodies (anti-human)
- 19 IHC (p) Antibodies (anti-human)
- 34 FACS Antibodies (anti-human)
- 48 IF (p) Antibodies (anti-human)
- 145 WB Antibodies (anti-human)
- 1 IP Antibody (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 1 ICC Antibody (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 15 FACS Antibodies (anti-mouse)
- 36 IF (p) Antibodies (anti-mouse)
- 93 WB Antibodies (anti-mouse)
- 19 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 5 IHC Antibodies (anti-human)
- 6 IF Antibodies (anti-human)
- 14 IP Antibodies (anti-human)
- 19 IHC (p) Antibodies (anti-human)
- 34 FACS Antibodies (anti-human)
- 48 IF (p) Antibodies (anti-human)
- 145 WB Antibodies (anti-human)
- 1 IP Antibody (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 1 ICC Antibody (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 15 FACS Antibodies (anti-mouse)
- 36 IF (p) Antibodies (anti-mouse)
- 93 WB Antibodies (anti-mouse)
- GeneTex FLT3 antibody for FLT3
-
Custom Antibody ServicesProSci Antibodies for FLT3
-
Santa Cruz Biotechnology (SCBT) Antibodies for FLT3
- Sino Biological Antibodies for FLT3
Protein Products
- R&D Systems Proteins and Enzymes for FLT3 (Flt-3/Flk-2)
- Search Origene for MassSpec and Protein Over-expression Lysates for FLT3
- Origene Custom Protein Services for FLT3
- Sino Biological Recombinant Proteins for FLT3
- Sino Biological Cell Lysates for FLT3
-
Cloud-Clone Corp. Proteins for FLT3
- Search GeneTex for Proteins for FLT3
-
Abcam proteins for FLT3
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays, ELISAs, and other biochemical assays for FLT3 (Flt-3/Flk-2)
- Cell Signaling Technology (CST) Sandwich ELISA Kits for FLT3 (FLT3)
-
Cloud-Clone Corp. Assay Kits for FLT3
- antibodies-online: Search results for 40 available FLT3 Elisa Kits ranked by validation data
- Compare Top FLT3 Elisa Kits
-
Recommended
- 2 Rat (Rattus) ELISA Kits
- 4 Rabbit ELISA Kits
- 1 Pig (Porcine) ELISA Kit
- 14 Mouse (Murine) ELISA Kits
- 1 Monkey ELISA Kit
- 23 Human ELISA Kits
- 1 Guinea Pig ELISA Kit
- 1 Chicken ELISA Kit
- 2 Rat (Rattus) ELISA Kits
- 4 Rabbit ELISA Kits
- 1 Pig (Porcine) ELISA Kit
- 14 Mouse (Murine) ELISA Kits
- 1 Monkey ELISA Kit
- 23 Human ELISA Kits
- 1 Guinea Pig ELISA Kit
- 1 Chicken ELISA Kit
Domains & Families for FLT3 Gene
Gene Families for FLT3 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Disease related genes
- Enzymes
- FDA approved drug targets
- Predicted membrane proteins
Protein Domains for FLT3 Gene
Suggested Antigen Peptide Sequences for FLT3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P36888UniProtKB/Swiss-Prot:
FLT3_HUMAN :- The juxtamembrane autoregulatory region is important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of bound ligand. Upon tyrosine phosphorylation, it mediates interaction with the SH2 domains of numerous signaling partners. In-frame internal tandem duplications (ITDs) result in constitutive activation of the kinase. The activity of the mutant kinase can be stimulated further by FLT3LG binding.
- Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
- Domain:
-
- The juxtamembrane autoregulatory region is important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of bound ligand. Upon tyrosine phosphorylation, it mediates interaction with the SH2 domains of numerous signaling partners. In-frame internal tandem duplications (ITDs) result in constitutive activation of the kinase. The activity of the mutant kinase can be stimulated further by FLT3LG binding.
- Family:
-
- Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Function for FLT3 Gene
Molecular function for FLT3 Gene
- GENATLAS Biochemistry:
- fms-related receptor tyrosine kinase 3,expressed on endothelial cell,duplicated in childhood acute myeloid leukemia with poor prognosis and acute lymphoblastic leukemia but not in myelodysplastic syndrome
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Present in an inactive conformation in the absence of bound ligand. FLT3LG binding leads to dimerization and activation by autophosphorylation.
- UniProtKB/Swiss-Prot Function:
- Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
Enzyme Numbers (IUBMB) for FLT3 Gene
Phenotypes From GWAS Catalog for FLT3 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004672 | protein kinase activity | IEA | -- |
GO:0004713 | protein tyrosine kinase activity | IEA | -- |
GO:0004714 | transmembrane receptor protein tyrosine kinase activity | IEA,TAS | 19549778 |
GO:0004896 | cytokine receptor activity | ISS | -- |
GO:0005021 | vascular endothelial growth factor-activated receptor activity | TAS | 8394751 |
Phenotypes for FLT3 Gene
- MGI mutant phenotypes for FLT3:
- inferred from 7 alleles
- GenomeRNAi human phenotypes for FLT3:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability in esophageal squamous lineage
- Decreased ionizing radiation sensitivity
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Increased transferrin (TF) endocytosis
- Decreased viability
- Decreased shRNA abundance
- Increased shRNA abundance
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Decreased substrate adherent cell growth
- Increased Sindbis virus (SINV) infection
- Condensed cis-Golgi
- Decreased IL-13 protein expression
- Increased senescence-associated beta-galactosidase protein expression after pRB stimulation
Animal Models for FLT3 Gene
- MGI Knock Outs for FLT3:
-
- Flt3 tm1Irl
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FLT3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FLT3 gene
- Search ViGene Biosciences for FLT3
CRISPR Products
-
OriGene CRISPR knockouts for FLT3
- genomics-online: gRNA clones - Search results for 115 available FLT3 gene related products
- Overview of 115 available FLT3 gene related products
- Applied Biological Materials CRISPR for FLT3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FLT3
- GenScript: Design CRISPR guide RNA sequences for FLT3
miRNA for FLT3 Gene
- miRTarBase miRNAs that target FLT3
miRNA Products
- Search ViGene Biosciences for FLT3
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for FLT3
- Browse OriGene Inhibitory RNA Products For FLT3
- genomics-online: shRNA clones - Search results for 115 available FLT3 gene related products
- Overview of 115 available FLT3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for FLT3 gene
Clone Products
- Sino Biological Human cDNA Clone for FLT3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for FLT3
- Applied Biological Materials Clones for FLT3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for FLT3 (Flt-3/Flk-2)
Cell Line Products
-
Horizon Cell Lines for FLT3
-
ViGene Biosciences adenoviral particle packaged cDNA for FLT3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FLT3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FLT3 gene
No data available for Transcription Factor Targets and HOMER Transcription for FLT3 Gene
Localization for FLT3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FLT3 Gene
- Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen. Note=Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation.
- Endoplasmic reticulum (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005783 | endoplasmic reticulum | IEA,IDA | -- |
GO:0005788 | endoplasmic reticulum lumen | IEA | -- |
GO:0005829 | cytosol | IEA | -- |
Pathways & Interactions for FLT3 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | GPCR Pathway |
.73
.62
|
.55
|
2 | ERK Signaling |
.61
.58
|
.49
|
3 | Nanog in Mammalian ESC Pluripotency |
.61
|
.48
|
4 | Actin Nucleation by ARP-WASP Complex |
.41
|
|
5 | PEDF Induced Signaling |
Pathways by source for FLT3 Gene
1 Cell Signaling Technology pathway for FLT3 Gene
2 BioSystems pathways for FLT3 Gene
3 Reactome pathways for FLT3 Gene
1 PharmGKB pathway for FLT3 Gene
9 KEGG pathways for FLT3 Gene
1 GeneGo (Thomson Reuters) pathway for FLT3 Gene
3 R&D Systems pathways for FLT3 Gene
Interacting Proteins for FLT3 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001776 | leukocyte homeostasis | ISS | -- |
GO:0002318 | myeloid progenitor cell differentiation | ISS | -- |
GO:0002328 | pro-B cell differentiation | ISS | -- |
GO:0006468 | protein phosphorylation | IEA | -- |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | TAS,IEA | 7507245 |
Drugs & Compounds for FLT3 Gene
(96) Drugs for FLT3 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Sunitinib | Approved, Investigational | Pharma | Target, inhibitor | VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor, RTK inhibitor, Potent VEGFR, PDGFRbeta and KIT inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 518 | |
Sorafenib | Approved, Investigational | Pharma | Target, antagonist, inhibitors, inhibitor | Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 717 | |
Idarubicin | Approved | Pharma | inhibitor | 226 | ||
midostaurin | Approved, Investigational | Pharma | Target, antagonist, inhibitor | Kinase Inhibitors | 0 | |
ponatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors, Fibroblast growth factor receptor (FGFR)inhibitors | 36 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Full agonist, Agonist | 58-64-0 |
|
(3) Tocris Compounds for FLT3 Gene
Compound | Action | Cas Number |
---|---|---|
5'-Fluoroindirubinoxime | FLT3 inhibitor; displays antiproliferative activity | 861214-33-7 |
CHMFL-FLT3-122 | Potent and selective FLT3 inhibitor | 1839150-56-9 |
TCS 359 | Potent FLT3 inhibitor | 301305-73-7 |
(30) ApexBio Compounds for FLT3 Gene
Compound | Action | Cas Number |
---|---|---|
5'-Fluoroindirubinoxime | 861214-33-7 | |
AMG 925 | FLT3/CDK4 inhibitor,potent and selective | 1401033-86-0 |
Amuvatinib (MP-470, HPK 56) | Tyrosine kinase inhibitor | 850879-09-3 |
AZD2932 | inhibitor of VEGFR-2, PDGFRβ, Flt-3, and c-Kit | 883986-34-3 |
BIBF 1120 | VEGFR/PDGF/FGFR inhibitor | 656247-17-5 |
CHIR-124 | Chk1 inhibitor,novel and potent | 405168-58-3 |
Dovitinib (TKI-258, CHIR-258) | Multitargeted RTK inhibitor | 405169-16-6 |
Dovitinib Dilactic acid | 852433-84-2 | |
ENMD-2076 | Selective Aurora A/Flt3 inhibitor | 934353-76-1 |
G-749 | FLT3 inhibitor | 1457983-28-6 |
KW 2449 | Multikinase inhibitor | 1000669-72-6 |
Lestaurtinib | JAK2/FLT3/TrkA inhibitor | 111358-88-4 |
Linifanib (ABT-869) | VEGFR/PDGFR inhibitor | 796967-16-3 |
Pacritinib | Selective JAK2/FLT3 inhibitor | 937272-79-2 |
Pacritinib (SB1518) | JAK2/FLT3 inhibitor | 937272-79-2 |
Quizartinib (AC220) | FLT3 inhibitor,potent and selective | 950769-58-1 |
SB1317 | CDK,JAK and FLT inhibitor | 937270-47-8 |
Silvestrol | Antineoplastic | 697235-38-4 |
Sorafenib | Raf kinases and tyrosine kinases inhibitor | 284461-73-0 |
SU14813 double bond Z | Tyrosine kinase inhibitor | 452105-23-6 |
SU14813 maleate | VEGFR/PDGFR/Kit/FLT-3 inhibitor | 849643-15-8 |
SU5416 | VEGF receptor inhibitor and AHR agonist | 204005-46-9 |
Sunitinib malate | VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor | 341031-54-7 |
Tandutinib (MLN518) | FLT3 inhibitor,potent and selective | 387867-13-2 |
TCS 359 | Potent FLT3 inhibitor | 301305-73-7 |
TG 100801 | Multi-kinase inhibitor | 867331-82-6 |
TG 100801 Hydrochloride | VEGFr2 inhibitor | 1018069-81-2 |
TG101209 | JAK2/3 inhibitor | 936091-14-4 |
UNC2025 | 1429881-91-3 | |
VX-680 (MK-0457,Tozasertib) | Aurora kinase inhibitor | 639089-54-6 |
Transcripts for FLT3 Gene
mRNA/cDNA for FLT3 Gene
- (8) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (17) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FLT3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FLT3
- genomics-online: gRNA clones - Search results for 115 available FLT3 gene related products
- Overview of 115 available FLT3 gene related products
- Applied Biological Materials CRISPR for FLT3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FLT3
- GenScript: Design CRISPR guide RNA sequences for FLT3
miRNA Products
- Search ViGene Biosciences for FLT3
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for FLT3
- Browse OriGene Inhibitory RNA Products For FLT3
- genomics-online: shRNA clones - Search results for 115 available FLT3 gene related products
- Overview of 115 available FLT3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for FLT3 gene
Clone Products
- Sino Biological Human cDNA Clone for FLT3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for FLT3
- Applied Biological Materials Clones for FLT3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for FLT3 (Flt-3/Flk-2)
Expression for FLT3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- pre Conventional Dendritic Cells Peripheral Blood
- Granulocyte-Monocyte Progenitor Cells Hematopoietic Bone Marrow
- B-cell Progenitor Cells Peripheral Blood
- Common Dendritic Cell Precursors Hematopoietic Bone Marrow
- Common Lymphoid Progenitor Cells Hematopoietic Bone Marrow
- Bone (Muscoskeletal System)
- Umbilical Cord (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for FLT3 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FLT3 Gene
NURSA nuclear receptor signaling pathways regulating expression of FLT3 Gene:
FLT3SOURCE GeneReport for Unigene cluster for FLT3 Gene:
Hs.507590mRNA Expression by UniProt/SwissProt for FLT3 Gene:
P36888-FLT3_HUMANEvidence on tissue expression from TISSUES for FLT3 Gene
- Blood(4.7)
- Bone marrow(4.7)
- Spleen(3.4)
- Lymph node(3.3)
- Liver(2.1)
- Heart(2)
- Lung(2)
- Nervous system(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for FLT3 Gene
- mesoderm
- immune
- lymphatic
- blood
- bone marrow
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for FLT3
- genomics-online: primer clones - Search results for 115 available FLT3 gene related products
- Overview of 115 available FLT3 gene related products
Orthologs for FLT3 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | FLT3 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | FLT3 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | FLT3 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Flt3 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Flt3 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | FLT3 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | FLT3 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | FLT3 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | FLT3 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | flt3 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | flt3 33 34 |
|
- Species where no ortholog for FLT3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FLT3 Gene
Paralogs for FLT3 Gene
(16) SIMAP similar genes for FLT3 Gene using alignment to 3 proteins:
Variants for FLT3 Gene
SNP ID | Clin | Chr 13 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1057519726 | likely-pathogenic, pathogenic, Acute myeloid leukemia | 28,018,502(-) | T/A/C/G | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
rs1057519762 | likely-pathogenic, Acute myeloid leukemia | 28,018,484(-) | A/G | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
rs1057519763 | likely-pathogenic, Acute myeloid leukemia | 28,018,504(-) | TC/AA | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
rs1057519764 | likely-pathogenic, Acute myeloid leukemia | 28,027,222(-) | A/C/T | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
rs1057519765 | likely-pathogenic, Acute myeloid leukemia | 28,027,236(-) | T/A/C | coding_sequence_variant, missense_variant, non_coding_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1336289 | CNV | insertion | 17803354 |
esv2674990 | CNV | deletion | 23128226 |
esv2677792 | CNV | deletion | 23128226 |
esv275421 | CNV | loss | 21479260 |
esv3349981 | CNV | insertion | 20981092 |
esv34052 | CNV | loss | 18971310 |
esv3550234 | CNV | deletion | 23714750 |
esv3550235 | CNV | deletion | 23714750 |
esv3580585 | CNV | loss | 25503493 |
esv3631627 | CNV | loss | 21293372 |
esv3631628 | CNV | loss | 21293372 |
esv3631630 | CNV | loss | 21293372 |
esv3631631 | CNV | loss | 21293372 |
esv3631632 | CNV | loss | 21293372 |
nsv1070579 | CNV | deletion | 25765185 |
nsv826599 | CNV | loss | 20364138 |
nsv973 | CNV | insertion | 18451855 |
Additional Variant Information for FLT3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLT3 Gene
Disorders for FLT3 Gene

(35) MalaCards diseases for FLT3 Gene - From: HGMD, OMIM, ClinVar, Orphanet, DISEASES, Novoseek, and GeneCards
Disorder | Aliases | PubMed IDs |
---|---|---|
leukemia, acute myeloid |
|
|
acute myeloid leukemia with minimal differentiation |
|
|
leukemia, acute lymphoblastic |
|
|
acute myeloblastic leukemia without maturation |
|
|
acute myeloblastic leukemia with maturation |
|
|
UniProtKB/Swiss-Prot
FLT3_HUMAN- Leukemia, acute myelogenous (AML) [MIM:601626]: A subtype of acute leukemia, a cancer of the white blood cells. AML is a malignant disease of bone marrow characterized by maturational arrest of hematopoietic precursors at an early stage of development. Clonal expansion of myeloid blasts occurs in bone marrow, blood, and other tissue. Myelogenous leukemias develop from changes in cells that normally produce neutrophils, basophils, eosinophils and monocytes. {ECO:0000269 PubMed:11090077, ECO:0000269 PubMed:11290608, ECO:0000269 PubMed:11442493, ECO:0000269 PubMed:14504097, ECO:0000269 PubMed:16266983, ECO:0000269 PubMed:18305215, ECO:0000269 PubMed:8946930, ECO:0000269 PubMed:9737679}. Note=The gene represented in this entry may be involved in disease pathogenesis. Somatic mutations that lead to constitutive activation of FLT3 are frequent in AML patients. These mutations fall into two classes, the most common being in-frame internal tandem duplications of variable length in the juxtamembrane region that disrupt the normal regulation of the kinase activity. Likewise, point mutations in the activation loop of the kinase domain can result in a constitutively activated kinase.
Additional Disease Information for FLT3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for FLT3 Gene
Publications for FLT3 Gene
- High transcript level of FLT3 associated with high risk of relapse in pediatric acute myeloid leukemia. (PMID: 20514303) Kang HJ … Ahn HS (Journal of Korean medical science 2010) 3 22 44 58
- Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia. (PMID: 20212254) Ravandi F … Kantarjian HM (Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010) 3 22 44 58
- Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations in acute promyelocytic leukemia: a systematic review. (PMID: 20096459) Beitinjaneh A … Majhail NS (Leukemia research 2010) 3 22 44 58
- The impact on outcome of the addition of all-trans retinoic acid to intensive chemotherapy in younger patients with nonacute promyelocytic acute myeloid leukemia: overall results and results in genotypic subgroups defined by mutations in NPM1, FLT3, and CEBPA. (PMID: 19965647) Burnett AK … Gale RE (Blood 2010) 3 22 44 58
- [FLT3 mutation in patients with acute lymphoblastic leukemia and its clinical significance]. (PMID: 19968062) Zhao X … Wang JX (Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 2009) 3 22 44 58
Products for FLT3 Gene
- R&D Systems Antibodies for FLT3 (Flt-3/Flk-2)
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- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for FLT3 (Flt-3/Flk-2)
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- Cell Signaling Technology (CST) Antibodies for FLT3 (FLT3)
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- Sino Biological Human cDNA Clone for FLT3
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- Browse Primary Antibodies
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- Browse Knockouts at Cloud-Clone Corp.
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- Cloud-Clone Corp. disease models service
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- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for FLT3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for FLT3
- Addgene plasmids for FLT3
- antibodies-online: Search results for 367 available FLT3 Antibodies ranked by validation data
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- 2 IHC Antibodies (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 1 ICC Antibody (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 1 IP Antibody (anti-mouse)
- 145 WB Antibodies (anti-human)
- 48 IF (p) Antibodies (anti-human)
- 34 FACS Antibodies (anti-human)
- 19 IHC (p) Antibodies (anti-human)
- 14 IP Antibodies (anti-human)
- 6 IF Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-rat)
- 19 WB Antibodies (anti-rat)
- 93 WB Antibodies (anti-mouse)
- 36 IF (p) Antibodies (anti-mouse)
- 15 FACS Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 1 ICC Antibody (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 1 IP Antibody (anti-mouse)
- 145 WB Antibodies (anti-human)
- 48 IF (p) Antibodies (anti-human)
- 34 FACS Antibodies (anti-human)
- 19 IHC (p) Antibodies (anti-human)
- 14 IP Antibodies (anti-human)
- 6 IF Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-rat)
- 19 WB Antibodies (anti-rat)
- antibodies-online: Search results for 40 available FLT3 Elisa Kits ranked by validation data
- Compare Top FLT3 Elisa Kits
- Recommended
- 1 Chicken ELISA Kit
- 1 Guinea Pig ELISA Kit
- 23 Human ELISA Kits
- 1 Monkey ELISA Kit
- 14 Mouse (Murine) ELISA Kits
- 1 Pig (Porcine) ELISA Kit
- 4 Rabbit ELISA Kits
- 2 Rat (Rattus) ELISA Kits
- 1 Chicken ELISA Kit
- 1 Guinea Pig ELISA Kit
- 23 Human ELISA Kits
- 1 Monkey ELISA Kit
- 14 Mouse (Murine) ELISA Kits
- 1 Pig (Porcine) ELISA Kit
- 4 Rabbit ELISA Kits
- 2 Rat (Rattus) ELISA Kits
- antibodies-online: Search results for 29 available FLT3 Proteins ranked by validation data
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- GeneTex FLT3 antibody for FLT3
- Search GeneTex for Proteins for FLT3
- ViGene Biosciences adenoviral particle packaged cDNA for FLT3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FLT3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FLT3 gene
- Search ViGene Biosciences for FLT3
- Santa Cruz Biotechnology (SCBT) Antibodies for FLT3
- Search Santa Cruz Biotechnology (SCBT) for FLT3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FLT3
- Custom Antibody ServicesProSci Antibodies for FLT3
- Search for FLT3 Proteins at ProSci
- Horizon Cell Lines for FLT3
- genomics-online: cdna clones - Search results for 115 available FLT3 gene related products
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Sources for FLT3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
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- (39) Pseudogene
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- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
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- (60) TGDB
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- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
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- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
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- (92) COMPARTMENTS
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- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
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- (157) EPDnew