Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FLT3 Gene

protein-coding   GIFtS: 71
GCID: GC13M028577

Fms-Related Tyrosine Kinase 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Fms-Related Tyrosine Kinase 31 2     FL Cytokine Receptor2 3
Fms-Like Tyrosine Kinase 32 3     EC 2.7.10.13 8
Stem Cell Tyrosine Kinase 12 3     Fetal Liver Kinase 22
CD1352 3     Growth Factor Receptor Tyrosine Kinase Type III2
FLK-22 3     Receptor-Type Tyrosine-Protein Kinase FLT32
FLK22 3     FLT-33
STK-12 3     Fetal Liver Kinase-23
STK12 3     EC 2.7.108
CD135 Antigen2 3     

External Ids:    HGNC: 37651   Entrez Gene: 23222   Ensembl: ENSG000001220257   OMIM: 1363515   UniProtKB: P368883   

Export aliases for FLT3 gene to outside databases

Previous GC identifers: GC13M026557 GC13M022557 GC13M027507 GC13M026375 GC13M027475 GC13M009398


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FLT3 Gene:
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an
extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic
kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the
fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma
membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently
phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis,
proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the
constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
(provided by RefSeq, Jul 2008)

GeneCards Summary for FLT3 Gene:
FLT3 (fms-related tyrosine kinase 3) is a protein-coding gene. Diseases associated with FLT3 include leukemia, acute lymphoblastic, somatic, and minimally differentiated acute myeloblastic leukemia. GO annotations related to this gene include phosphatidylinositol 3-kinase binding and protein homodimerization activity. An important paralog of this gene is FLT4.

UniProtKB/Swiss-Prot: FLT3_HUMAN, P36888
Function: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates
differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes
phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS
signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes
phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type
FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity
promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways

summary for FLT3 Gene:
FMS-like receptor tyrosine kinase-3 (FLT3) is a member of the class III RTK (receptor tyrosine kinase)
family and is expressed primarily in hematopoietic progenitor cells. The expression within these cells
demonstrates that FLT3 has an important role in the pathogenesis of AML (acute myelogenous leukemia), under
which conditions wild type receptors are overexpressed or mutated forms of the receptor are present.
Inhibitors of both mutated and wild type receptors are therefore of interest in a therapeutic context.

Gene Wiki entry for FLT3 (CD135) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000013.11  NC_018924.2  NT_024524.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the FLT3 gene promoter:
         STAT5B   Pax-5   AP-1   ATF-2   GATA-2   C/EBPalpha   STAT3   c-Jun   NF-kappaB1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFLT3 promoter sequence
   Search Chromatin IP Primers for FLT3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FLT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12   Ensembl cytogenetic band:  13q12.2   HGNC cytogenetic band: 13q12

FLT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FLT3 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M028577:  view genomic region     (about GC identifiers)

Start:
28,577,411 bp from pter      End:
28,674,729 bp from pter
Size:
97,319 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FLT3_HUMAN, P36888 (See protein sequence)
Recommended Name: Receptor-type tyrosine-protein kinase FLT3 precursor  
Size: 993 amino acids; 112903 Da
Subunit: Monomer in the absence of bound FLT3LG. Homodimer in the presence of bound FLT3LG. Interacts with FIZ1
following ligand activation (By similarity). Interacts with FES, FER, LYN, FGR, HCK, SRC and GRB2. Interacts with
PTPRJ/DEP-1 and PTPN11/SHP2
Miscellaneous: Can be used as diagnostic tool to establish the exact cause of acute myeloid leukemia, and to
determine the optimal therapy
3 PDB 3D structures from and Proteopedia for FLT3:
1RJB (3D)        3QS7 (3D)        3QS9 (3D)    
Secondary accessions: A0AVG9 B7ZLT7 B7ZLT8 F5H0A0 Q13414
Alternative splicing: 2 isoforms:  P36888-1   P36888-2   

Explore the universe of human proteins at neXtProt for FLT3: NX_P36888

Explore proteomics data for FLT3 at MOPED

Post-translational modifications: 

  • N-glycosylated, contains complex N-glycans with sialic acid1
  • Autophosphorylated on several tyrosine residues in response to FLT3LG binding. FLT3LG binding also increases
    phosphorylation of mutant kinases that are constitutively activated. Dephosphorylated by PTPRJ/DEP-1, PTPN1,
    PTPN6/SHP-1, and to a lesser degree by PTPN12. Dephosphorylation is important for export from the endoplasmic
    reticulum and location at the cell membrane1
  • Rapidly ubiquitinated by UBE2L6 and the E3 ubiquitin-protein ligase SIAH1 after autophosphorylation, leading to
    its proteasomal degradation1
  • Ubiquitination2 at Lys614, Lys623
  • Glycosylation2 at Asn43, Asn100, Asn151, Asn306, Asn323, Asn351, Asn354, Asn473, Asn502, Asn541
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for FLT3 (P36888) (see all 13)
     VAVKMLK  RDLAARN  ALMSELK  WEIFSLG 


    See FLT3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004110.2  
    ENSEMBL proteins: 
     ENSP00000241453   ENSP00000370374   ENSP00000370369   ENSP00000438139  

    FLT3 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant FLT3 Protein
    R&D Systems Recombinant & Natural Proteins for FLT3 (Flt-3/Flk-2)
    Enzo Life Sciences proteins for FLT3
    OriGene Purified Proteins for FLT3
    OriGene Protein Over-expression Lysate for FLT3
    OriGene MassSpec for FLT3
    OriGene Custom Protein Services for FLT3
    GenScript Custom Purified and Recombinant Proteins Services for FLT3
    Novus Biologicals FLT3 Proteins
    Novus Biologicals FLT3 Lysate
    Sino Biological Recombinant Protein for FLT3
    Sino Biological Cell Lysate for FLT3
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    FLT3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of FLT3
    R&D Systems Antibodies for FLT3 (Flt-3/Flk-2)
    Cell Signaling Technology (CST) Antibodies for FLT3 
    OriGene Antibodies for FLT3
    OriGene Custom Antibody Services for FLT3
    Novus Biologicals FLT3 Antibodies
    Search for Antibodies for FLT3 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for FLT3
    LSBio Antibodies in human, mouse, rat for FLT3

    FLT3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FLT3
    R&D Systems ELISAs for FLT3 (Flt-3/Flk-2)         (see all)
    GenScript FLT3-Activity-based Kinase Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for FLT3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: fms-related tyrosine kinase 3
    PDGF (platelet-derived growth factor) receptor family
    PDGF (platelet-derived growth factor) receptor family

    Selected InterPro protein domains (see all 12):
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold
     IPR000719 Prot_kinase_dom
     IPR001824 Tyr_kinase_rcpt_3_CS

    Graphical View of Domain Structure for InterPro Entry P36888

    ProtoNet protein and cluster: P36888

    2 Blocks protein domains:
    IPB003599 Immunoglobulin subtype
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: FLT3_HUMAN, P36888
    Domain: The juxtamembrane autoregulatory region is important for normal regulation of the kinase activity and for
    maintaining the kinase in an inactive state in the absence of bound ligand. Upon tyrosine phosphorylation, it
    mediates interaction with the SH2 domains of numerous signaling partners. In-frame internal tandem duplications
    (ITDs) result in constitutive activation of the kinase. The activity of the mutant kinase can be stimulated
    further by FLT3LG binding
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 protein kinase domain


    FLT3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FLT3_HUMAN, P36888
    Function: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates
    differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes
    phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS
    signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes
    phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type
    FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity
    promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Present in an inactive conformation in the absence of bound ligand. FLT3LG binding leads to
    dimerization and activation by autophosphorylation

         Genatlas biochemistry entry for FLT3:
    fms-related receptor tyrosine kinase 3,expressed on endothelial cell,duplicated in childhood acute myeloid
    leukemia with poor prognosis and acute lymphoblastic leukemia but not in myelodysplastic syndrome

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004714transmembrane receptor protein tyrosine kinase activity TAS19549778
    GO:0004896cytokine receptor activity ISS--
    GO:0005021vascular endothelial growth factor-activated receptor activity TAS8394751
         
    FLT3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FLT3:
     Decreased substrate adherent c  Decreased viability 

         7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Flt3):
     cellular  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  tumorigenesis 

    FLT3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Flt3tm1Irl for FLT3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FLT3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FLT3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FLT3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FLT3

    miRNA
    Products:
        
    miRTarBase miRNAs that target FLT3:
    hsa-mir-335-5p (MIRT017462), hsa-mir-150-5p (MIRT007053)

    Block miRNA regulation of human, mouse, rat FLT3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FLT3 (see all 33):
    hsa-miR-3194-5p hsa-miR-15a hsa-miR-1245 hsa-miR-139-5p hsa-miR-3074-3p hsa-miR-570 hsa-miR-3142 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidFLT3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FLT3
    Predesigned siRNA for gene silencing in human, mouse, rat FLT3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FLT3

    Clone
    Products:
         
    OriGene clones in human, mouse for FLT3 (see all 8)
    OriGene ORF clones in mouse, rat for FLT3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FLT3 (NM_004119)
    Sino Biological Human cDNA Clone for FLT3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FLT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLT3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FLT3
    Browse ESI BIO Cell Lines and PureStem Progenitors for FLT3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLT3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FLT3_HUMAN, P36888: Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen.
    Note=Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to
    the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen.
    The activated kinase is rapidly targeted for degradation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane4
    extracellular2
    nucleus2
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005788endoplasmic reticulum lumen IEA--
    GO:0005887integral component of plasma membrane TAS8394751
    GO:0009986cell surface IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    FLT3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FLT3 About   (see all 17)  
    See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    Endothelin-1 Signaling Pathway0.46
    Cytokine-cytokine receptor interaction0.43
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    3ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    5Actin Nucleation by ARP-WASP Complex
    Actin Nucleation and Branching0.66
    CDC42 Pathway0.41
    Actin Nucleation by ARP-WASP Complex0.66

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FLT3 (see all 29)
        FLT3 Signaling
    MAPK Signaling
    Paxillin Interactions
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer

    1 Cell Signaling Technology (CST) Pathway for FLT3
        Tyrosine Kinases / Adaptors

    1 GeneGo (Thomson Reuters) Pathway for FLT3
        Development Flt3 signaling


    1 PharmGKB Pathway for FLT3
        Sorafenib Pharmacodynamics

    5 Kegg Pathways  (Kegg details for FLT3):
        Cytokine-cytokine receptor interaction
    Hematopoietic cell lineage
    Pathways in cancer
    Transcriptional misregulation in cancer
    Acute myeloid leukemia


    FLT3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FLT3: 
              Antigen Presenting Cells in human mouse rat
              Lymphoma in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FLT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FLT3 (P368881, 2, 3 ENSP000002414534) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279861, 2, 3, ENSP000002743354EBI-3946257,EBI-79464 MINT-7103574 MINT-7103585 I2D: score=2 STRING: ENSP00000274335
    PTPN11Q061242, 3, ENSP000003409444MINT-8030324 MINT-8030340 I2D: score=1 STRING: ENSP00000340944
    IKBKGQ9Y6K91, 3, ENSP000003586224EBI-3946257,EBI-81279 I2D: score=1 STRING: ENSP00000358622
    SOCS1O155243, ENSP000003294184I2D: score=4 STRING: ENSP00000329418
    INPP5DQ928353, ENSP000003525754I2D: score=3 STRING: ENSP00000352575
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001776leukocyte homeostasis ISS--
    GO:0002318myeloid progenitor cell differentiation ISS--
    GO:0002320lymphoid progenitor cell differentiation ----
    GO:0002328pro-B cell differentiation ISS--
    GO:0002572pro-T cell differentiation IEA--

    FLT3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for FLT3 (see all 12)     About this table
    CompoundAction CAS #
    Amuvatinib (MP-470, HPK 56)Multi-kinase inhibitor, inhibits PDGFR, c-Kit, and Flt3[850879-09-3]
    AST 487high selectivity and potency toward FLT3[630124-46-8]
    Cabozantinib (XL184, BMS-907351)Multi-target kinase inhibitor, inhibits c-Met, VEGFR2, and RET[849217-68-1]
    KW 2449multiple-targeted inhibitor, mostly for Flt3[1000669-72-6]
    LestaurtinibPotent JAK2, FLT3 and TrkA inhibitor[111358-88-4]
    Linifanib (ABT-869)ATP-competitive, multi-targeted RTK inhibitor[796967-16-3]
    Ponatinib (AP24534)pan-BCR-ABL inhibitor[943319-70-8]
    Quizartinib (AC220)Potent and selective FLT3 inhibitor[950769-58-1]
    SB1317inhibits CDKs 1, 2, 7 and 9 together with JAK2 and FLT3[937270-47-8]
    SU5416VEGF receptor inhibitor and an aryl hydrocarbon receptor (AHR) agonist[204005-46-9]

    Compounds for FLT3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TCS 359Potent FLT3 inhibitor[301305-73-7]
    5'-FluoroindirubinoximeFLT3 inhibitor; displays antiproliferative activity[861214-33-7]

    2 HMDB Compounds for FLT3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    3 DrugBank Compounds for FLT3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    SunitinibSU011248 (see all 2)557795-19-4targetmultitarget14654525 12531805 15304385 15180525 11752352 14753710
    Sorafenib-- 284461-73-0targetantagonist17229632 17205056
    Ponatinib -- 943319-70-8targetinhibitor23430109

    1 IUPHAR Ligand for FLT3 (fms-related tyrosine kinase 3)    About this table
    LigandTypeActionAffinityPubmed IDs
    Fms-related tyrosine kinase 3 ligand
    NoneNone--

    Selected Novoseek inferred chemical compound relationships for FLT3 gene (see all 40)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pkc 412 91.7 85 17330105 (5), 18071308 (5), 15956279 (4), 15150124 (4) (see all 27)
    lestaurtinib 88.1 22 16868253 (4), 16857985 (2), 20141349 (2), 18341639 (2) (see all 7)
    tyrosine 85.3 556 17851558 (7), 15345597 (4), 9737679 (3), 14726387 (3) (see all 99)
    tandutinib 84.9 24 16902153 (4), 15256420 (3), 15242881 (3), 19625780 (3) (see all 6)
    ag-1296 80.8 21 11455967 (7), 12357354 (2), 17050201 (2), 18509353 (2) (see all 6)
    sunitinib 74.2 28 17889720 (4), 17041096 (3), 17591828 (1), 18192256 (1) (see all 20)
    daniplestim 67.8 1 10781904 (1)
    imatinib 67.8 30 18797870 (3), 14976243 (2), 15180525 (2), 11290609 (1) (see all 13)
    sorafenib 67.5 37 17229632 (6), 18230792 (4), 17889720 (4), 17205056 (2) (see all 20)
    su5416 62.1 11 15158089 (5), 12351406 (2), 17169805 (1), 12649163 (1) (see all 5)



    FLT3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FLT3 gene: 
    NM_004119.2  

    Unigene Cluster for FLT3:

    Fms-related tyrosine kinase 3
    Hs.507590  [show with all ESTs]
    Unigene Representative Sequence: NM_004119
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000241453(uc001urw.3 uc010aao.3 uc010tdn.2) ENST00000380987
    ENST00000469894 ENST00000380982 ENST00000537084
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FLT3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FLT3 (see all 33):
    hsa-miR-3194-5p hsa-miR-15a hsa-miR-1245 hsa-miR-139-5p hsa-miR-3074-3p hsa-miR-570 hsa-miR-3142 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidFLT3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FLT3
    Predesigned siRNA for gene silencing in human, mouse, rat FLT3
    Clone
    Products:
         
    OriGene clones in human, mouse for FLT3 (see all 8)
    OriGene ORF clones in mouse, rat for FLT3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FLT3 (NM_004119)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FLT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLT3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FLT3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FLT3
      QuantiTect SYBR Green Assays in human, mouse, rat FLT3
      QuantiFast Probe-based Assays in human, mouse, rat FLT3

    Additional mRNA sequence: 

    BC126350.1 BC144039.1 BC144040.1 L36162.1 U02687.1 Z26652.1 

    4 DOTS entries:

    DT.120782229  DT.104253  DT.75174632  DT.91675080 

    17 AceView cDNA sequences:

    BF589957 BC036028 BX279530 BU681356 L36162 AW059681 U02687 NM_004119 
    AV713950 Z26652 AW772610 AI150354 BI461248 AW057705 BF170536 BF176247 
    BF170584 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FLT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTGATTCCA
    FLT3 Expression
    About this image


    FLT3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 17 entries
             Common Lymphoid Progenitor Cells Hematopoietic Bone Marrow
             Bone Marrow CD133+ Cells   
             clps   
     
     Umbilical Cord (Extraembryonic Tissues)
             stem cells (umbilical cord cd34+)   
     
     Bone (Muscoskeletal System)
             BONE MARROW   
    FLT3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FLT3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.507590

    UniProtKB/Swiss-Prot: FLT3_HUMAN, P36888
    Tissue specificity: Detected in bone marrow, in hematopoietic stem cells, in myeloid progenitor cells and in
    granulocyte/macrophage progenitor cells (at protein level). Detected in bone marrow, liver, thymus, spleen and
    lymph node, and at low levels in kidney and pancreas. Highly expressed in T-cell leukemia

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FLT3: 
              Antigen Presenting Cells in human mouse rat
              Lymphoma in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FLT3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FLT3
    QuantiTect SYBR Green Assays in human, mouse, rat FLT3
    QuantiFast Probe-based Assays in human, mouse, rat FLT3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for FLT3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Flt31 , 5 FMS-like tyrosine kinase 31, 5 83.15(n)1
    86.18(a)1
      5 (86.88 cM)5
    142551  NM_010229.21  NP_034359.21 
     1473307415 
    chicken
    (Gallus gallus)
    Aves FLT31 fms-related tyrosine kinase 3 65.12(n)
    57.13(a)
      100858422  XM_003640612.2  XP_003640660.2 
    lizard
    (Anolis carolinensis)
    Reptilia FLT36
    fms-related tyrosine kinase 3
    52(a)
    1 ↔ 1
    3(185864344-185941774)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia flt31 fms-related tyrosine kinase 3 59.73(n)
    51.99(a)
      101733150  XM_004912385.1  XP_004912442.1 
    zebrafish
    (Danio rerio)
    Actinopterygii flt31 fms-related tyrosine kinase 3 53.5(n)
    45.67(a)
      566708  XM_001921725.2  XP_001921760.2 


    ENSEMBL Gene Tree for FLT3 (if available)
    TreeFam Gene Tree for FLT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FLT3 gene
    FLT42  FGFR42  PDGFRB2  CSF1R2  KIT2  FGFR32  PDGFRA2  RET2  
    KDR2  FGFR12  FGFR22  FLT12  
    16 SIMAP similar genes for FLT3 using alignment to 3 protein entries:     FLT3_HUMAN (see all proteins):
    STK-1    RET    NIN/PDGFRB fusion    ABL1    KIT    FES
    CSF1R    FGR    urf-ret    EPHA2    DKFZp686M05208    CDK4
    FGFR2    tec    PDGFRA    TIE1

    FLT3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FLT3 (see all 2552)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0656834
    Acute lymphoblastic leukemia patients4--see VAR_0656832 D Y mis40--------
    VAR_0656824
    Acute lymphoblastic leukemia patients4--see VAR_0656822 D V mis40--------
    VAR_0656844
    Acute lymphoblastic leukemia patients4--see VAR_0656842 I M mis40--------
    VAR_0656804
    Acute lymphoblastic leukemia patients4--see VAR_0656802 D H mis40--------
    VAR_0656814
    Acute lymphoblastic leukemia patients4--see VAR_0656812 D N mis40--------
    VAR_0656794
    Acute lymphoblastic leukemia patients4--see VAR_0656792 D E mis40--------
    rs1219096461,2
    Cother19547186(-) TCGAGA/TTATCA 2 D V mis10--------
    rs1219134881,2
    Cother19547187(-) CTCGAA/C/G/
            
    ATATC
    4 N H D Y mis10--------
    rs1816549321,2
    --9531466(+) GTTCCA/GGATCC 1 -- ds50010--------
    rs1870561381,2
    C--9531491(+) CTACAC/TGCAAC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for FLT3 (28577411 - 28674729 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for FLT3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2674990CNV Deletion23128226
    esv2677792CNV Deletion23128226
    esv1336289CNV Insertion17803354
    nsv973CNV Insertion18451855
    esv269085CNV Insertion20981092
    esv275421CNV Loss21479260
    esv34052CNV Loss18971310
    nsv826599CNV Loss20364138

    Human Gene Mutation Database (HGMD): FLT3
    Selected Site Specific Mutation Identification with PCR Assays for FLT3 (see all 20):
    Cosmic IdAA Change
    27979p.E596_Y597ins12
    783p.D835Y
    28047p.R834Q
    19522p.V592A
    24531p.M837P
    Selected Site Specific Cancer Mutation PCR Panels containing FLT3 (see all 9):
    Hematopoietic Neoplasms
    FLT3 Pathway
    Cancer Comprehensive Panel 384HT
    Oncogene Panel 384HT
    Receptor Tyrosine Kinase (RTK) (Panel I)
    SeqTarget long-range PCR primers for resequencing FLT3
    DNA2.0 Custom Variant and Variant Library Synthesis for FLT3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 136351   
    OMIM disorders: 601626  613065  
    UniProtKB/Swiss-Prot: FLT3_HUMAN, P36888
  • Leukemia, acute myelogenous (AML) [MIM:601626]: A subtype of acute leukemia, a cancer of the white blood
    cells. AML is a malignant disease of bone marrow characterized by maturational arrest of hematopoietic precursors
    at an early stage of development. Clonal expansion of myeloid blasts occurs in bone marrow, blood, and other
    tissue. Myelogenous leukemias develop from changes in cells that normally produce neutrophils, basophils,
    eosinophils and monocytes. Note=The gene represented in this entry may be involved in disease pathogenesis.
    Somatic mutations that lead to constitutive activation of FLT3 are frequent in AML patients. These mutations fall
    into two classes, the most common being in-frame internal tandem duplications of variable length in the
    juxtamembrane region that disrupt the normal regulation of the kinase activity. Likewise, point mutations in the
    activation loop of the kinase domain can result in a constitutively activated kinase

  • Selected diseases for FLT3 (see all 71):    
    About MalaCards
    leukemia, acute lymphoblastic, somatic    minimally differentiated acute myeloblastic leukemia    leukemia, acute myeloid, reduced survival in    acute myeloblastic leukemia without maturation
    acute myeloid leukemia    tetraploidy    acute biphenotypic leukemia    core binding factor acute myeloid leukemia
    acute myeloblastic leukemia with maturation    cytogenetically normal acute myeloid leukemia    acute myelomonocytic leukemia    lymphoblastic leukemia
    8p11 myeloproliferative syndrome    acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)    bone marrow cancer    myeloid sarcoma
    myeloid leukemia    acute myeloid leukemia with t(8;21)(q22;q22) translocation    chronic myeloproliferative disease    acute leukemia

    2 diseases from the University of Copenhagen DISEASES database for FLT3:
    Leukemia     Bone marrow cancer

    FLT3 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for FLT3 gene (see all 73)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aml adult 85.2 22 12750701 (2), 15054042 (1), 15996732 (1), 10764154 (1), 15085154 (1), 15166029 (1), 17230226 (1), 16642044 (1), 15167911 (1), 20137111 (1), 16914901 (1), 16330434 (1), 18668134 (1), 10233379 (1), 12854887 (1), 12791658 (1), 14504097 (1), 16213360 (1), 18094582 (1) (see top 4)
    leukemogenesis 81.6 32 17485549 (2), 12239147 (2), 14562119 (2), 10505320 (2), 15253381 (1), 15604885 (1), 15781338 (1), 17442779 (1), 8637235 (1), 18841055 (1), 15498859 (1), 16868253 (1), 15735040 (1), 12681969 (1), 17079011 (1), 18068628 (1), 17330105 (1), 18927438 (1), 16761019 (1), 16990784 (1) (see top 4)
    aml childhood 80.8 29 15166029 (4), 20514303 (3), 15010072 (2), 17763464 (2), 10049058 (2), 15251987 (2), 10233379 (1), 8641369 (1), 12750701 (1), 16291592 (1), 11133746 (1), 20001230 (1), 10573574 (1), 14504097 (1), 16912228 (1), 18345718 (1) (see top 4)
    leukemia 79.8 215 19541823 (6), 17330105 (5), 17332306 (5), 14555522 (4), 11455967 (3), 12515727 (3), 18977066 (3), 18925699 (3), 12176867 (2), 17671144 (2), 12357354 (2), 17598835 (2), 9305595 (2), 15105287 (2), 17983653 (2), 18450602 (2), 15982343 (2), 12010785 (2), 16025155 (2), 16757428 (2), 16800917 (2), 16034464 (2), 18394702 (2), 19958352 (2), 10233379 (2), 19035305 (2), 10446914 (1), 15179004 (1), 16709517 (1), 16573741 (1), 16838337 (1), 17041096 (1), 17851558 (1), 17851551 (1), 18388181 (1), 19052976 (1), 12400596 (1), 14670924 (1), 14726387 (1), 15253381 (1), 12791658 (1), 12899708 (1), 11585760 (1), 10194124 (1), 8394751 (1), 17708788 (1), 19643984 (1), 18760705 (1), 9828230 (1), 17940205 (1), 17712416 (1), 16861351 (1), 16213360 (1), 15778081 (1), 14732923 (1), 12842996 (1), 20127944 (1), 18071308 (1), 15755900 (1), 15242881 (1), 15059064 (1), 14604973 (1), 12627848 (1), 12145695 (1), 11406763 (1), 10720129 (1), 8637236 (1), 8637235 (1), 8562934 (1), 20026798 (1), 18452067 (1), 18345718 (1), 18097642 (1), 18155552 (1), 17205056 (1), 16410383 (1), 16585200 (1), 16982328 (1), 14982881 (1), 9305596 (1), 1384791 (1), 20072157 (1), 19671038 (1), 19491417 (1), 18820131 (1), 18160102 (1), 17942916 (1), 16582613 (1), 15061200 (1), 15010072 (1), 12815052 (1), 12935959 (1), 12399960 (1), 10766177 (1), 11721383 (1), 17202314 (1), 16446383 (1), 15585651 (1), 15352981 (1) (see top 4)
    acute leukemia 73.4 56 17584026 (4), 15778081 (3), 17387224 (2), 18925699 (2), 20302766 (2), 20515557 (2), 12357354 (1), 15996732 (1), 17233551 (1), 19052976 (1), 8677746 (1), 20072157 (1), 1384791 (1), 10803532 (1), 16757428 (1), 12796379 (1), 16800917 (1), 16321848 (1), 16185475 (1), 10373018 (1), 19075657 (1), 16557239 (1), 12836614 (1), 15374944 (1), 16025155 (1), 15618475 (1), 8562934 (1), 20425341 (1), 17708815 (1), 17943971 (1), 8637232 (1), 20370649 (1), 15950498 (1), 18977066 (1), 15150124 (1), 16418499 (1), 17584149 (1) (see top 4)
    lymphoblastic leukemia acute 68.2 35 16234090 (2), 18024407 (2), 19968062 (2), 12176867 (1), 15956279 (1), 17156841 (1), 7535088 (1), 8946930 (1), 12400596 (1), 15604885 (1), 17205058 (1), 17584026 (1), 10720156 (1), 8641368 (1), 19085113 (1), 14604973 (1), 16594743 (1), 14504097 (1), 17708788 (1), 18760705 (1), 17881645 (1), 15044257 (1), 15583855 (1), 16116483 (1), 17942916 (1), 1384791 (1), 8637232 (1), 9324277 (1) (see top 4)
    leukemia promyelocytic acute 67.7 26 16105978 (2), 19176014 (2), 17939400 (2), 20096459 (2), 17064989 (2), 20133893 (2), 12973844 (2), 15179004 (1), 16619525 (1), 17454189 (1), 15167911 (1), 12399960 (1), 12551822 (1), 19052993 (1), 15889156 (1), 9305596 (1), 17606455 (1), 16076872 (1) (see top 4)
    myelodysplastic syndromes 67.6 27 16902153 (2), 15036894 (2), 16787503 (2), 15257941 (2), 9324277 (2), 9737679 (1), 12145988 (1), 12176867 (1), 14737077 (1), 19276253 (1), 10697556 (1), 18503825 (1), 17079011 (1), 11319806 (1), 17708788 (1), 16938665 (1), 10233379 (1), 9305595 (1), 15329908 (1), 17169806 (1), 17156841 (1), 12357354 (1), 15345597 (1) (see top 4)
    minimal residual disease 64 12 12239147 (3), 15645287 (2), 19176010 (1), 12854887 (1), 19603346 (1), 10720156 (1) (see top 4)
    myeloproliferative disorders 63.8 8 16761019 (2), 16557239 (1), 16938665 (1), 17076649 (1), 11756186 (1), 15374944 (1), 18706197 (1) (see top 4)

    Genetic Association Database (GAD): FLT3
    Human Genome Epidemiology (HuGE) Navigator: FLT3 (128 documents)

    Export disorders for FLT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FLT3 gene, integrated from 10 sources (see all 1089):
    (articles sorted by number of sources associating them with FLT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells. (PubMed id 8394751)1, 2, 3, 9 Rosnet O.... Birnbaum D. (Blood 1993)
    2. [Correlation of FLT3 gene expression level and internal tandem duplication mutation in acute myeloid leukemia and its clinical significance]. (PubMed id 19176010)1, 4, 9 Wang Y.G....Jin J. (Zhonghua Xue Ye Xue Za Zhi 2008)
    3. [Correlation of Fms-like tyrosine kinase 3 (FLT3) gene expression to FLT3/internal tandem duplication mutation in peripheral blood of acute myeloid leukemia.]. (PubMed id 19635202)1, 4, 9 Xu B....Zhou S.Y. (Ai Zheng 2009)
    4. Mutations of the FLT3 gene in adult acute myeloid leukemia: determination of incidence and identification of a novel mutation in a Thai population. (PubMed id 16213360)1, 4, 9 Auewarakul C.U....Yenchitsomanus P.T. (Cancer Genet. Cytogenet. 2005)
    5. An innovative phase I clinical study demonstrates inhibition of FLT3 phosphorylation by SU11248 in acute myeloid leukemia patients. (PubMed id 14654525)1, 7, 9 O'Farrell A.M....Cherrington J.M. (Clin. Cancer Res. 2003)
    6. Structural and functional alterations of FLT3 in acute myeloid leukemia. (PubMed id 19549778)1, 2, 9 Meshinchi S. and Appelbaum F.R. (Clin. Cancer Res. 2009)
    7. Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/macrophage progenitor stages to maintain cell survival. (PubMed id 18490735)1, 2, 9 Kikushige Y.... Akashi K. (J. Immunol. 2008)
    8. Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia. (PubMed id 17910045)1, 4, 9 Paulsson K....Johansson B. (amp 2008)
    9. Detection of FLT3 gene and FLT3/ITD mutation by polymerase chain reaction-single-strand conformation polymorphism in patients with acute lymphoblastic leukemia. (PubMed id 16234090)1, 4, 9 Xu B....Zhou S.Y. (Di Yi Jun Yi Da Xue Xue Bao 2005)
    10. High transcript level of FLT3 associated with high risk of relapse in pediatric acute myeloid leukemia. (PubMed id 20514303)1, 4, 9 Kang H.J....Ahn H.S. (J. Korean Med. Sci. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2322 HGNC: 3765 AceView: FLT3 Ensembl:ENSG00000122025 euGenes: HUgn2322
    ECgene: FLT3 Kegg: 2322 H-InvDB: FLT3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FLT3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FLT3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FLT3 gene:
    Search GeneIP for patents involving FLT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of FLT3
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Purified and/or Recombinant FLT3 Protein
     
     EMD Millipore genomic analysis products

      
     Antibodies for FLT3 (Flt-3/Flk-2)   Browse Cell Culture Products  
     ELISAs for FLT3 (Flt-3/Flk-2)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for FLT3 (Flt-3/Flk-2)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for FLT3 (Flt-3/Flk-2)  
     OriGene Antibodies for FLT3   OriGene RNAi products in human, mouse, rat for FLT3  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for FLT3  
     OriGene MassSpec something-or-other for FLT3   OriGene clones in human, mouse for FLT3  
     OriGene qSTAR qPCR primer pairs in human, mouse for FLT3   OriGene Purified Protein for FLT3  
     OriGene ORF clones in mouse, rat for FLT3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FLT3   OriGene Custom Protein Services for FLT3  

     
     
     Block miRNA regulation of human, mouse, rat FLT3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FLT3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FLT3 Predesigned siRNA for gene silencing in human, mouse, rat FLT3
     QuantiFast Probe-based Assays in human, mouse, rat FLT3 QuantiTect SYBR Green Assays in human, mouse, rat FLT3
     PCR Arrays including human, mouse, rat FLT3 Search Chromatin IP Primers for FLT3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FLT3  GeneGlobe Interaction Network for FLT3
     Regulatory tfbs in FLT3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for FLT3 GenScript cDNA clones with any tag delivered in your preferred vector for FLT3
     GenScript FLT3-Activity-based Kinase Assay for Compound Screening GenScript Custom overexpressing Cell Line Services for FLT3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for FLT3 

     Tocris compounds for FLT3
     Proteins for FLT3
     Cell Lysates for FLT3
     cDNA Clones for FLT3
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for FLT3
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FLT3 antibodies
     FLT3 proteins
     FLT3 lysates
     Search for Antibodies for FLT3 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for FLT3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for FLT3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLT3
     SwitchGear 3'UTR luciferase reporter plasmids for FLT3
     SwitchGear Promoter luciferase reporter plasmids for FLT3
     ThermoFisher Antibody for FLT3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLT3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FLT3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FLT3
     LSBio Antibodies in human, mouse, rat for FLT3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     ApexBio compounds for FLT3
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FLT3 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4