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FLT3 Gene

protein-coding GIFtS: 72

GC13M027475

fms-related tyrosine kinase 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
CD135 ^¹, ²
EC 2.7.10.1 ^³
FLK2 ^¹, ²
OTTHUMP00000042340 ^²
STK-1 ^³
STK1 ^¹, ², ³

Descriptions
CD135 antigen ^², ³
FL cytokine receptor ^²
FLT3 receptor tyrosine kinase ^²
Stem cell tyrosine kinase 1 ^², ³
Tyrosine-protein kinase receptor FLT3 ^², ³
fetal liver kinase 2 ^²
fms-related tyrosine kinase 3 ^²
growth factor receptor tyrosine kinase type III ^²

External Ids
HGNC: 3765¹
Entrez Gene: 2322²
UniProtKB: P36888³
Ensembl: ENSG00000122025⁷

Search outside databases for aliases for FLT3 gene

Previous GC identifers: GC13M026557 GC13M022557 GC13M027507 GC13M026375

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FLT3:

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor

consists of an extracellular domain composed of five immunoglobulin-like domains, one

transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert

domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the

extracellular domain, which induces homodimer formation in the plasma membrane leading to

autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and

activates multiple cytoplasmic effector molecules in pathways involved in apoptosis,

proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in

the constitutive activation of this receptor result in acute myeloid leukemia and acute

lymphoblastic leukemia. [provided by RefSeq]

UniProtKB/Swiss-Prot: FLT3_HUMAN, P36888

Function: Receptor for the FL cytokine. Has a tyrosine-protein kinase activity

Gene Wiki entry for FLT3 (CD135)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FLT3 gene

Entrez Gene cytogenetic band: 13q12 Ensembl cytogenetic band: 13q12.2 HGNC cytogenetic band: 13q12

FLT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13M027475: (about GC identifiers)

Start:	27,475,411 bp from pter
End:	27,572,729 bp from pter
Size:	97,319 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000013.9 NT_024524.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: FLT3_HUMAN, P36888 (See protein sequence)

Recommended Name: FL cytokine receptor precursor

Size: 993 amino acids; 112903 Da

Subunit: Interacts with FIZ1 following ligand activation (By similarity)

Subcellular location: Membrane; Single-pass type I membrane protein

PDB structures from and Proteopedia :

1RJB (3D)

Secondary accessions: A0AVG9 Q13414

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004110.2

ENSEMBL proteins:

ENSP00000370369 ENSP00000370374 ENSP00000241453

Human Recombinant Proteins

	Invitrogen human recombinant proteins for FLT3
	Millipore Purified and/or Recombinant FLT3 Protein
	Sigma-Aldrich Proteins for FLT3
	R&D Systems Recombinant & Natural Proteins for FLT3 (Flt-3)
	Enzo Life Sciences proteins for FLT3
	Recombinant Proteins from Abcam (Flt3 / CD135)
	Human Recombinant Proteins from Abnova (FLT3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	TAS	8394751
GO:0016020	membrane	IEA	--

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Antibodies for FLT3:

	Invitrogen Antibodies for FLT3
	Millipore Mono- and Polyclonal Antibodies for the study of FLT3
	Sigma-Aldrich Antibodies for FLT3
	R&D Systems Antibodies for FLT3 (Flt-3)
	Cell Signaling Technology (CST) Antibodies for FLT3
	Antibodies from Abcam (Flt3 / CD135), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (FLT3)
	Novus Biologicals Antibodies for FLT3

Assays for FLT3:

	Invitrogen Assays for FLT3
	Millipore Kits and Assays for the Analysis of FLT3
	R&D Systems ELISAs for FLT3 (Flt-3) (see all)
	Cell Signaling Technology (CST) Sandwich ELISA Kits for FLT3
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P36888

ProtoNet protein and cluster: P36888

2 Blocks protein families:

IPB003599 Immunoglobulin subtype

IPB008266 Tyrosine protein kinase

UniProtKB/Swiss-Prot: FLT3_HUMAN, P36888

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF

receptor subfamily

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FLT3)
		Millipore RNAi Products for the Analysis of FLT3 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (FLT3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004119

Applied Biosystems Silencer® siRNAs for FLT3

Sigma-Aldrich siRNA and siRNA Panels for FLT3

Sigma-Aldrich shRNA Panels and shRNA for FLT3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004119
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004119
untagged cDNA clones in CMV expression vector (see all 2): NM_004119

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004119

UniProtKB/Swiss-Prot: FLT3_HUMAN, P36888

Function: Receptor for the FL cytokine. Has a tyrosine-protein kinase activity

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Enzyme Number (IUBMB): EC 2.7.10.1

Genatlas biochemistry entry for FLT3:

fms-related receptor tyrosine kinase 3,expressed on endothelial cell,duplicated in childhood acute

myeloid leukemia with poor prognosis and acute lymphoblastic leukemia but not in myelodysplastic

syndrome

5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Flt3):

life span-post-weaning/aging

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004872	receptor activity	IEA	--
GO:0005021	vascular endothelial growth factor receptor activity	TAS	8394751
GO:0005524	ATP binding	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for FLT3 (Your Favorite Gene powered by Ingenuity)

FLT3 Signaling in Hematopoietic Progenitor Cells
Acute Myeloid Leukemia Signaling

GeneDecks FLT3 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for FLT3

5/59 Interacting proteins for FLT3 (ENSP00000370369³) via UniProtKB, MINT, and/or STRING (see all 59 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FIZ1	ENSP00000221665³	STRING (score=.993)
SPI1	ENSP00000367799³	STRING (score=.99)
STAT5A	ENSP00000341208³	STRING (score=.954)
FLT3LG	ENSP00000204637³	STRING (score=.953)
GRB2	ENSP00000339007³	STRING (score=.95)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein amino acid phosphorylation	IEA	--
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	TAS	7507245
GO:0008284	positive regulation of cell proliferation	TAS	7507245
GO:0030097	hemopoiesis	IDA	7507245

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for FLT3:

Inhibitor

Compounds for FLT3 available from Tocris Bioscience

Compound	Action	CAS number
SU 5416	VEGFR inhibitor. Also inhibits c-kit, Ret, MET and FLT3	[204005-46-9]
Lestaurtinib	JAK2, FLT3 and TrkA inhibitor	[111358-88-4]
TCS 359	Potent FLT3 inhibitor	[301305-73-7]

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10/19 Novoseek chemical compound relationships for FLT3 gene (see all 19 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
lestaurtinib	86.13	17	16868253 (4), 16857985 (2), 18341639 (2), 18797870 (1)
tyrosine	84.90	494	17851558 (7), 15345597 (4), 9737679 (3), 14726387 (3) (see all 99)
mln 518	84.36	19	16902153 (4), 15256420 (3), 15242881 (3), 15585651 (2) (see all 5)
ag-1296	82.08	21	11455967 (7), 12357354 (2), 17050201 (2), 18509353 (2) (see all 6)
daniplestim	71.03	1	10781904 (1)
pixy321	58.62	2	12881174 (1), 11551032 (1)
17-(allylamino)-17-demethoxygeldanamycin	40.37	8	16034464 (4), 17332306 (2), 18373709 (1)
gp 130	33.31	4	9373247 (2), 10419883 (1), 14725899 (1)
agarose	5.73	3	14984498 (2)
tgf beta1	0.43	1	15498125 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FLT3)
		Millipore RNAi Products for the Analysis of FLT3 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (FLT3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004119

Sigma-Aldrich siRNA and siRNA Panels for FLT3

Sigma-Aldrich shRNA Panels and shRNA for FLT3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004119

REFSEQ mRNAs for FLT3 gene:

NM_004119.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004119

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004119
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004119
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004119

Additional cDNA sequence:

BC126350.1 BC144039.1 BC144040.1 L36162.1 U02687.1 Z26652.1

4 DOTS entries:

DT.120782229 DT.104253 DT.91675080 DT.75174632

17 AceView cDNA sequences:

BF589957 BC036028 BU681356 BX279530 AW059681 AV713950 NM_004119 Z26652

U02687 L36162 AW772610 AI150354 BI461248 AW057705 BF170536 BF176247

BF170584

highest scoring ESTs for FLT3:

U02687 BI461248 Z26652 AW057705 AW059681 AW772610 BF170536 BF176247 BF589957 BM147250

Unigene Cluster for FLT3:

Fms-related tyrosine kinase 3

Hs.507590 [show with all ESTs]

Unigene Representative Sequence: NM_004119

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000380982 ENST00000380987 ENST00000241453

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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FLT3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FLT3

¹ / ² / ³

4 probe-sets matching FLT3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34583_at²^{, 3}	U95-A	1	1.00	1.00	0.97	0.87	U02687	1.00	1.00	1.00	1
1065_at²^{, 3}	U95-A	1	1.00	1.00	0.94	1.14	U02687	1.00	1.00	1.00	1
206674_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004119	0.60	1.00	0.82	1
206674_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGTGATTCCA

SOURCE GeneReport for Unigene cluster: Hs.507590
Expression variation in blood from EXPOLDB for FLT3
UniProtKB/Swiss-Prot: FLT3_HUMAN, P36888
Tissue specificity: Bone marrow cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FLT3 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	FLT3¹	--	fms-related tyrosine kinase 3	90.74(n) 91.84(a)	486025 NM_001020811.1 NP_001018647.1
chimpanzee (Pan troglodytes)	FLT3¹	--	fms-related tyrosine kinase 3	99.6(n) 98.99(a)	452508 XM_509601.2 XP_509601.2
cow (Bos taurus)	FLT3¹	--	fms-related tyrosine kinase 3	88.27(n) 90.64(a)	512700 XM_590263.3 XP_590263.3
rat (Rattus norvegicus)	Flt3¹	--	fms-related tyrosine kinase 3	82.31(n) 84.53(a)	140635 XM_221874.4 XP_221874.4
mouse (Mus musculus)	Flt3^{1, 5}	5 (82.00 cM)⁵	FMS-like tyrosine kinase 3^{1, 5}	83.15(n)¹ 86.18(a)¹	14255¹ NM_010229.2¹ NP_034359.2¹ AK045865⁵ AK149292⁵ (see all 12)

About this table Species with no ortholog for FLT3

ENSEMBL Gene Tree for FLT3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FLT3 gene

CSF1R² KIT²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/990 NCBI SNPs in FLT3 are shown (see all 990 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 191)

AB	SNP ID	Valid	Chr 13 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1933437^1,2	A,C,F,H	27522294(-)	`TGGGAT/CGGACA`	1	M/T	mis¹ ese³		11		MN EU EA WA NA	1186
--	rs1999364^1,2	A,C,F,H	27475035(-)	`GGCTTA/C/GTGAAC`	1	--	ng5¹		12		EU EA WA NA	1044
	rs3829382^1,2	A,C,F,H	27475688(+)	`AGGGGG/TTTCGT`	1	--	ut3¹ ese³		12		EU EA WA NA	1050
--	rs35602083^1,2	C,F	27521587(+)	`GGTGTC/TGTTTC`	1	D/N	mis¹		4		EU EA WA	420
--	rs35958982^1,2	C,F	27506473(+)	`TAAAAC/TGACAA`	1	V/I	mis¹		4		EU EA WA	420
	rs11616983^1,2	H	27573186(+)	`TAAGAA/CCCATT`	1	--	ng3¹		4		EU EA WA	418
	rs1999365^1,2	H	27474964(-)	`CTCTTC/TTTTCT`	1	--	ng5¹		4		EU EA WA	396
--	rs12872889^1,2	A	27572628(+)	`CGCCGC/TCGCGC`	1	D/G	mis¹ ese³		0	--	--	--	--
	rs7338903^1,2	A,C,F,H	27534084(+)	`GGGGCA/GTCGAC`	1	D/D	syn¹ ese³		7		EU EA WA NA	546
	rs34374211^1,2	C,F	27506459(+)	`CAAATT/CAGCAG`	1	L/L	syn¹		1		NA	76

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HapMap Linkage Disequilibrium images for FLT3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 136351

10/72 Novoseek disease relationships for FLT3 gene (see all 72 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
aml adult	85.13	21	12750701 (2), 15054042 (1), 15996732 (1), 10764154 (1) (see all 18)
leukemogenesis	82.29	32	17485549 (2), 12239147 (2), 14562119 (2), 10505320 (2) (see all 20)
aml childhood	81.24	25	15166029 (4), 15010072 (2), 17763464 (2), 10049058 (2) (see all 14)
leukemia	79.32	198	17330105 (5), 17332306 (5), 14555522 (4), 11455967 (3) (see all 99)
acute leukemia	73.03	47	17584026 (4), 15778081 (3), 17387224 (2), 18925699 (2) (see all 32)
lymphoblastic leukemia acute	67.72	32	16234090 (2), 18024407 (2), 12176867 (1), 15956279 (1) (see all 26)
leukemia promyelocytic acute	67.09	22	16105978 (2), 19176014 (2), 12973844 (2), 17939400 (2) (see all 16)
myelodysplastic syndromes	66.76	27	16902153 (2), 15036894 (2), 16787503 (2), 15257941 (2) (see all 23)
myeloproliferative disorders	62.54	8	16761019 (2), 16557239 (1), 16938665 (1), 17076649 (1) (see all 7)
minimal residual disease	60.87	11	12239147 (3), 15645287 (2), 19176010 (1), 12854887 (1) (see all 5)

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1 PharmGKB disease relationship for FLT3 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

About this table

Human Gene Mutation Database: FLT3
Genetic Association Database: FLT3
Human Genome Epidemiology Navigator: FLT3 (50 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/773 PubMed articles for FLT3 gene (see all 773 ):

Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells. (PubMed id 8394751)^{1, 2, 3, 4} Rosnet O.... Birnbaum D. (1993)
Mutations of the FLT3 gene in adult acute myeloid leukemia: determination of incidence and identification of a novel mutation in a Thai population. (PubMed id 16213360)^{1, 3, 6} Auewarakul C.U....Yenchitsomanus P.T. (2005)
Detection of FLT3 gene and FLT3/ITD mutation by polymerase chain reaction-single-strand conformation polymorphism in patients with acute lymphoblastic leukemia. (PubMed id 16234090)^{1, 3, 6} Xu B....Zhou S.Y. (2005)
Clinical impact of internal tandem duplications and activating point mutations in FLT3 in acute myeloid leukemia in elderly patients. (PubMed id 15059064)^{1, 3, 6} Andersson A....Fioretos T. (2004)
STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells. (PubMed id 7507245)^{1, 3, 4} Small D.... Civin C.I. (1994)
Simultaneous detection of NPM1 and FLT3-ITD mutations by capillary electrophoresis in acute myeloid leukemia. (PubMed id 15973451)^{1, 3, 6} Noguera N.I....Lo-Coco F. (2005)
Prognostic significance of FLT3 mutations in pediatric non-promyelocytic acute myeloid leukemia. (PubMed id 15863200)^{1, 3, 6} Kang H.J....Ahn H.S. (2005)
[Detection of point mutation at second tyrosine kinase domain of FLT3 gene in acute myeloid leukemia] (PubMed id 16185475)^{1, 3, 6} Wang L.H....Wang J.X. (2005)
Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations for acute myeloid leukemia: a meta-analysis. (PubMed id 15959528)^{1, 3, 6} Yanada M....Naoe T. (2005)
D324N single-nucleotide polymorphism in the FLT3 gene is associated with higher risk of myeloid leukemias. (PubMed id 16320249)^{1, 3, 6} Schnittger S....Spiekermann K. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2322	HGNC: 3765	AceView: FLT3	Ensembl:ENSG00000122025	euGenes: HUgn2322
ECgene: FLT3	H-InvDB: FLT3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for FLT3	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for FLT3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for FLT3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FLT3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FLT3		Antibodies for FLT3
	Explore super-pooled esiRNAs		Proteins for FLT3
	Lentivirus-delivered shRNAs for FLT3		Small molecules for FLT3
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Recombinant & Natural Proteins

	Recombinant Proteins (FLT3)
	Antibodies (FLT3)
	Chimera RNAi (FLT3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for FLT3

	Recombinant Proteins (Flt3 / CD135)
	Antibodies (Flt3 / CD135)

Search OriGene for FLT3

Tocris compounds for FLT3

	Proteins for FLT3
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for FLT3

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
FLT3 Gene at Home site.
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FLT3 Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for FLT3

Summaries
for FLT3

Genomic Location
for FLT3

Proteins
for FLT3

Protein Domains/
Families
for FLT3

Gene Function
for FLT3

Pathways & Interactions
for FLT3

Drugs & Compounds
for FLT3

Transcripts
for FLT3

Expression
for FLT3

Orthologs
for FLT3

Paralogs
for FLT3

SNPs/Variants
for FLT3

Disorders & Mutations
for FLT3

Medical News
for FLT3

Publications
for FLT3

Search for FLT3

Genome Databases showing FLT3

Other Databases showing FLT3

Specialized Databases showing FLT3

Licensable Technologies
for FLT3

Services
for FLT3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FLT3 Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor FLT3

Summariesfor FLT3

Genomic Locationfor FLT3

Proteinsfor FLT3

Protein Domains/Familiesfor FLT3

Gene Functionfor FLT3

Pathways & Interactionsfor FLT3

Drugs & Compoundsfor FLT3

Transcriptsfor FLT3

Expression for FLT3

Orthologsfor FLT3

Paralogsfor FLT3

SNPs/Variantsfor FLT3

Disorders & Mutationsfor FLT3

Medical Newsfor FLT3

Publicationsfor FLT3

Search for FLT3

Genome Databases showing FLT3

Other Databases showing FLT3

Specialized Databases showing FLT3

Licensable Technologiesfor FLT3

Servicesfor FLT3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FLT3

Summaries
for FLT3

Genomic Location
for FLT3

Proteins
for FLT3

Protein Domains/
Families
for FLT3

Gene Function
for FLT3

Pathways & Interactions
for FLT3

Drugs & Compounds
for FLT3

Transcripts
for FLT3

Expression
for FLT3

Orthologs
for FLT3

Paralogs
for FLT3

SNPs/Variants
for FLT3

Disorders & Mutations
for FLT3

Medical News
for FLT3

Publications
for FLT3

Licensable Technologies
for FLT3

Services
for FLT3