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Aliases for FLT1 Gene

Aliases for FLT1 Gene

  • Fms-Related Tyrosine Kinase 1 2 3
  • Vascular Permeability Factor Receptor 2 3 4
  • Fms-Related Tyrosine Kinase 1 (Vascular Endothelial Growth Factor/Vascular Permeability Factor Receptor) 2 3
  • Vascular Endothelial Growth Factor Receptor 1 2 3
  • Tyrosine-Protein Kinase Receptor FLT 3 4
  • Tyrosine-Protein Kinase FRT 3 4
  • Fms-Like Tyrosine Kinase 1 3 4
  • EC 2.7.10.1 4 63
  • VEGFR-1 3 4
  • VEGFR1 3 4
  • FLT-1 3 4
  • FLT 3 4
  • EC 2.7.10 63
  • FRT 4

External Ids for FLT1 Gene

Previous HGNC Symbols for FLT1 Gene

  • FLT

Previous GeneCards Identifiers for FLT1 Gene

  • GC13M026854
  • GC13M022854
  • GC13M027805
  • GC13M026673
  • GC13M027773
  • GC13M028874
  • GC13M009695

Summaries for FLT1 Gene

Entrez Gene Summary for FLT1 Gene

  • This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]

GeneCards Summary for FLT1 Gene

FLT1 (Fms-Related Tyrosine Kinase 1) is a Protein Coding gene. Diseases associated with FLT1 include microcystic meningioma and eclampsia. Among its related pathways are PI3K-Akt signaling pathway and RhoGDI Pathway. GO annotations related to this gene include identical protein binding and growth factor binding. An important paralog of this gene is FGFR3.

UniProtKB/Swiss-Prot for FLT1 Gene

  • Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Likewise, isoforms lacking a transmembrane domain, such as isoform 2, isoform 3 and isoform 4, may function as decoy receptors for VEGFA. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Isoform 1 phosphorylates PLCG. Promotes phosphorylation of AKT1 at Ser-473. Promotes phosphorylation of PTK2/FAK1. Isoform 7 has a truncated kinase domain; it increases phosphorylation of SRC at Tyr-418 by unknown means and promotes tumor cell invasion.

Tocris Summary for FLT1 Gene

  • Vascular endothelial growth factor is a signaling protein involved in the regulation of angiogenesis and vasculogenesis. VEGF binds to and activates a receptor tyrosine kinase, VEGFR. Three VEGFR isoforms have been identified in humans; VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1) and VEGFR-3 (Flt-4). VEGFR-2 mediates the majority of cellular responses to VEGF. VEGFR-1 is thought to modulate VEGFR-2 signaling or to act as a dummy/decoy receptor to sequester VEGF away from VEGFR-2.

Gene Wiki entry for FLT1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLT1 Gene

Genomics for FLT1 Gene

Regulatory Elements for FLT1 Gene

Genomic Location for FLT1 Gene

Start:
28,300,344 bp from pter
End:
28,495,128 bp from pter
Size:
194,785 bases
Orientation:
Minus strand

Genomic View for FLT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FLT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FLT1 Gene

Proteins for FLT1 Gene

  • Protein details for FLT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17948-VGFR1_HUMAN
    Recommended name:
    Vascular endothelial growth factor receptor 1
    Protein Accession:
    P17948
    Secondary Accessions:
    • A3E342
    • A3E344
    • A8KA71
    • B0LPF1
    • B2BF46
    • B2BF47
    • B2BF48
    • B3FR89
    • B5A923
    • F5H5L6
    • O60722
    • P16057
    • Q12954

    Protein attributes for FLT1 Gene

    Size:
    1338 amino acids
    Molecular mass:
    150769 Da
    Quaternary structure:
    • Interacts with VEGFA, VEGFB and PGF. Monomer in the absence of bound VEGFA, VEGFB or PGF. Homodimer in the presence of bound VEGFA, VEGFB and PGF. Can also form a heterodimer with KDR. Interacts (when tyrosine phosphorylated) with CBL, CRK, GRB2, NCK1, PIK3R1, PLCG, PSEN1 and PTPN11. Probably interacts also with PTPRB. Interacts with GNB2L1/RACK1. Identified in a complex with CBL and CD2AP.

    Three dimensional structures from OCA and Proteopedia for FLT1 Gene

    Alternative splice isoforms for FLT1 Gene

neXtProt entry for FLT1 Gene

Proteomics data for FLT1 Gene at MOPED

Post-translational modifications for FLT1 Gene

  • Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-1169 is important for interaction with PLCG. Phosphorylation at Tyr-1213 is important for interaction with PIK3R1, PTPN11, GRB2, and PLCG. Phosphorylation at Tyr-1333 is important for endocytosis and for interaction with CBL, NCK1 and CRK. Is probably dephosphorylated by PTPRB.
  • N-glycosylated.
  • Ubiquitinated after VEGFA-mediated autophosphorylation, leading to proteolytic degradation.
  • Glycosylation at Asn100, Asn164, Asn196, Asn251, Asn323, Asn402, Asn417, Asn474, Asn547, Asn597, Asn620, Asn625, and Asn666
  • Modification sites at PhosphoSitePlus

Domains for FLT1 Gene

Gene Families for FLT1 Gene

HGNC:
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • ISET :Immunoglobulin superfamily / I-set domain containing
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

P17948

UniProtKB/Swiss-Prot:

VGFR1_HUMAN :
  • P17948
Domain:
  • The second and third Ig-like C2-type (immunoglobulin-like) domains are sufficient for VEGFA binding.
  • Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
genes like me logo Genes that share domains with FLT1: view

Function for FLT1 Gene

Molecular function for FLT1 Gene

GENATLAS Biochemistry: fms-related receptor tyrosine kinase 1,expressed on the surface on endothelial cells
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Present in an inactive conformation in the absence of bound ligand. Binding of VEGFA, VEGFB or PGF leads to dimerization and activation by autophosphorylation on tyrosine residues
UniProtKB/Swiss-Prot Function: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Likewise, isoforms lacking a transmembrane domain, such as isoform 2, isoform 3 and isoform 4, may function as decoy receptors for VEGFA. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Isoform 1 phosphorylates PLCG. Promotes phosphorylation of AKT1 at Ser-473. Promotes phosphorylation of PTK2/FAK1. Isoform 7 has a truncated kinase domain; it increases phosphorylation of SRC at Tyr-418 by unknown means and promotes tumor cell invasion.
UniProtKB/Swiss-Prot Induction: Up-regulated in coculture of VSMC/endothelial cell (EC) or by direct exposure to VEGF of VSMC monoculture. Up-regulated from the second trimester of pregnancy to the term and in the placenta of women with preeclampsia (PE). Up-regulated in monocytes exposed to bacterial lipopolysaccharide (LPS).

Enzyme Numbers (IUBMB) for FLT1 Gene

Gene Ontology (GO) - Molecular Function for FLT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity --
GO:0004714 transmembrane receptor protein tyrosine kinase activity TAS 8248162
GO:0005021 vascular endothelial growth factor-activated receptor activity IMP 11312102
GO:0005515 protein binding IPI 10543948
genes like me logo Genes that share ontologies with FLT1: view
genes like me logo Genes that share phenotypes with FLT1: view

Animal Models for FLT1 Gene

MGI Knock Outs for FLT1:

miRNA for FLT1 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for FLT1 Gene

Localization for FLT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLT1 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein. Endosome. Note=Autophosphorylation promotes ubiquitination and endocytosis.
Isoform 2: Secreted.
Isoform 3: Secreted.
Isoform 4: Secreted.
Isoform 5: Cytoplasm.
Isoform 6: Cytoplasm.
Isoform 7: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FLT1 Gene COMPARTMENTS Subcellular localization image for FLT1 gene
Compartment Confidence
endosome 5
extracellular 5
plasma membrane 5
golgi apparatus 4
nucleus 4
cytosol 3
cytoskeleton 2
endoplasmic reticulum 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FLT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 8248162
GO:0005768 endosome IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 11513746
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with FLT1: view

Pathways for FLT1 Gene

genes like me logo Genes that share pathways with FLT1: view

Gene Ontology (GO) - Biological Process for FLT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis --
GO:0001569 patterning of blood vessels IEA --
GO:0002040 sprouting angiogenesis IEA --
GO:0002548 monocyte chemotaxis IDA 18079407
GO:0006468 protein phosphorylation --
genes like me logo Genes that share ontologies with FLT1: view

Compounds for FLT1 Gene

(5) Tocris Compounds for FLT1 Gene

Compound Action Cas Number
Axitinib Potent VEGFR-1, -2 and -3 inhibitor [319460-85-0]
EG 00229 Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to NRP1 [1018927-63-3]
Sunitinib malate Potent VEGFR, PDGFRbeta and KIT inhibitor [341031-54-7]
ZM 306416 hydrochloride Inhibitor of VEGF receptor tyrosine kinase [196603-47-1]
ZM 323881 hydrochloride Potent, selective inhibitor of VEGFR-2 [193000-39-4]

(2) HMDB Compounds for FLT1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(6) Drugbank Compounds for FLT1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Axitinib
319460-85-0 target inhibitor
N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide
target
Pazopanib
  • GW-786034
444731-52-6 target inhibitor
Regorafenib
755037-03-7 target inhibitor
Sorafenib
284461-73-0 target inhibitor

(2) IUPHAR Ligand for FLT1 Gene

Ligand Type Action Affinity Pubmed IDs
VEGFA None None
VEGFB None None

(44) Novoseek inferred chemical compound relationships for FLT1 Gene

Compound -log(P) Hits PubMed IDs
vegf 96.1 405
tyrosine 84.4 208
matrigel 69.2 9
ptk787 68.3 1
zd6474 64.8 2

(2) PharmGKB related drug/compound annotations for FLT1 Gene

Drug/compound Annotation
pazopanib
regorafenib
genes like me logo Genes that share compounds with FLT1: view

Transcripts for FLT1 Gene

Unigene Clusters for FLT1 Gene

Fms-related tyrosine kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FLT1 Gene

No ASD Table

Relevant External Links for FLT1 Gene

GeneLoc Exon Structure for
FLT1
ECgene alternative splicing isoforms for
FLT1

Expression for FLT1 Gene

mRNA expression in normal human tissues for FLT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FLT1 Gene

SOURCE GeneReport for Unigene cluster for FLT1 Gene Hs.594454

mRNA Expression by UniProt/SwissProt for FLT1 Gene

P17948-VGFR1_HUMAN
Tissue specificity: Detected in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. Isoform 2 is strongly expressed in placenta. Isoform 3 is expressed in corneal epithelial cells (at protein level). Isoform 3 is expressed in vascular smooth muscle cells (VSMC).
genes like me logo Genes that share expressions with FLT1: view

No data available for mRNA differential expression in normal tissues for FLT1 Gene

Orthologs for FLT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FLT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FLT1 35
  • 99.43 (n)
  • 99.33 (a)
FLT1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FLT1 35
  • 85.19 (n)
  • 84.34 (a)
FLT1 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FLT1 35
  • 90.3 (n)
  • 89.98 (a)
FLT1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Flt1 35
  • 81.89 (n)
  • 82.12 (a)
Flt1 16
Flt1 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FLT1 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FLT1 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves FLT1 35
  • 73.02 (n)
  • 70.66 (a)
FLT1 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FLT1 36
  • 65 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii -- 35
flt1 35
  • 58.31 (n)
  • 54.07 (a)
flt1 36
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cad96Ca 36
  • 29 (a)
ManyToMany
Pvr 36
  • 21 (a)
ManyToMany
tor 37
  • 46 (a)
CG3277 37
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea ver-2 37
  • 27 (a)
kin-16 37
  • 32 (a)
ver-3 37
  • 22 (a)
R09D1.12 37
  • 30 (a)
Y50D4B.6 37
  • 43 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3210 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for FLT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FLT1 Gene

ENSEMBL:
Gene Tree for FLT1 (if available)
TreeFam:
Gene Tree for FLT1 (if available)

Paralogs for FLT1 Gene

Paralogs for FLT1 Gene

Pseudogenes.org Pseudogenes for FLT1 Gene

genes like me logo Genes that share paralogs with FLT1: view

Variants for FLT1 Gene

Sequence variations from dbSNP and Humsavar for FLT1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs583105 -- 28,480,882(-) CTTCC(A/G)TGGTG intron-variant
rs585421 -- 28,460,668(-) GGGGG(A/G)GTGGG intron-variant
rs588907 -- 28,467,875(-) CTACA(C/T)AAATA intron-variant
rs589809 -- 28,467,689(-) ACCTT(C/T)ATGGA intron-variant
rs598945 -- 28,494,303(-) GGGAC(G/T)TTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FLT1 Gene

Variant ID Type Subtype PubMed ID
esv34052 CNV Loss 18971310
nsv455850 CNV Loss 19166990

Relevant External Links for FLT1 Gene

HapMap Linkage Disequilibrium report
FLT1
Human Gene Mutation Database (HGMD)
FLT1
Locus Specific Mutation Databases (LSDB)
FLT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLT1 Gene

Disorders for FLT1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (12) Diseases for FLT1 Gene including...

Search for FLT1 Gene in MalaCards »

UniProtKB/Swiss-Prot

VGFR1_HUMAN
  • Note=Can contribute to cancer cell survival, proliferation, migration, and invasion, and tumor angiogenesis and metastasis. May contribute to cancer pathogenesis by promoting inflammatory responses and recruitment of tumor-infiltrating macrophages.
  • Note=Abnormally high expression of soluble isoforms (isoform 2, isoform 3 or isoform 4) may be a cause of preeclampsia.

(91) Novoseek inferred disease relationships for FLT1 Gene

Disease -log(P) Hits PubMed IDs
preeclampsia 85.1 159
neovascularization 78.4 26
tumors 65.4 183
proteinuria 56.3 14
intrauterine growth retardation 56.2 9

Relevant External Links for FLT1

Genetic Association Database (GAD)
FLT1
Human Genome Epidemiology (HuGE) Navigator
FLT1
Tumor Gene Database (TGDB):
FLT1
genes like me logo Genes that share disorders with FLT1: view

Publications for FLT1 Gene

  1. Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family. (PMID: 2158038) Shibuya M. … Sato M. (Oncogene 1990) 2 3 4 23
  2. The phosphorylated 1169-tyrosine containing region of flt-1 kinase (VEGFR-1) is a major binding site for PLCgamma. (PMID: 9299537) Sawano A. … Shibuya M. (Biochem. Biophys. Res. Commun. 1997) 3 4 23
  3. Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor. (PMID: 9393862) Wiesmann C. … de Vos A.M. (Cell 1997) 3 4 23
  4. Direct identification of a major autophosphorylation site on vascular endothelial growth factor receptor Flt-1 that mediates phosphatidylinositol 3'-kinase binding. (PMID: 11513746) Yu Y. … Sato J.D. (Biochem. J. 2001) 3 4 23
  5. Effect of placenta growth factor-1 on proliferation and release of nitric oxide, cyclic AMP and cyclic GMP in human epithelial cells expressing the FLT-1 receptor. (PMID: 11811792) Angelucci C. … Sica G. (Growth Factors 2001) 3 4 23

Products for FLT1 Gene

  • Addgene plasmids for FLT1

Sources for FLT1 Gene

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