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FLT1 Gene

protein-coding GIFtS: 72

GC13M027773

fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: FLT)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
EC 2.7.10.1 ^³
FLT ^², ³
FRT ^³
Flt-1 ^³
VEGFR-1 ^³
VEGFR1 ^²

Descriptions
Fms-like tyrosine kinase 1 ^³
Tyrosine-protein kinase FRT ^³
Tyrosine-protein kinase receptor FLT ^³
Vascular permeability factor receptor ^³
fms-related tyrosine kinase 1 ^²
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) ^²
vascular endothelial growth factor receptor 1 ^²

External Ids
HGNC: 3763¹
Entrez Gene: 2321²
UniProtKB: P17948³
Ensembl: ENSG00000102755⁷

Search outside databases for aliases for FLT1 gene

Previous GC identifers: GC13M026854 GC13M022854 GC13M027805 GC13M026673

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FLT1:

This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR

family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding

region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase

(TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental

growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this

receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood

monocytes. Multiple transcript variants encoding different isoforms have been found for this gene.

Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The

soluble isoforms are associated with the onset of pre-eclampsia.

UniProtKB/Swiss-Prot: VGFR1_HUMAN, P17948

Function: Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase

ligand/receptor signaling system plays a key role in vascular development and regulation of

vascular permeability. Isoform SFlt1 may have an inhibitory role in angiogenesis

Gene Wiki entry for FLT1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FLT1 gene

Entrez Gene cytogenetic band: 13q12 Ensembl cytogenetic band: 13q12.3 HGNC cytogenetic band: 13q12

FLT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13M027773: (about GC identifiers)

Start:	27,774,389 bp from pter
End:	27,967,265 bp from pter
Size:	192,877 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000013.9 NT_024524.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: VGFR1_HUMAN, P17948 (See protein sequence)

Recommended Name: Vascular endothelial growth factor receptor 1 precursor

Size: 1338 amino acids; 150769 Da

Subunit: Interacts in vitro with various phosphotyrosine-binding proteins, including PLC-gammas,

PTPN11, GRB2, CRK and NCK1

Subcellular location: Isoform Flt1: Cell membrane; Single-pass type I membrane protein

Subcellular location: Isoform sFlt1: Secreted

PDB structures from and Proteopedia :

1FLT (3D)

1QSV (3D)

1QSZ (3D)

1QTY (3D)

1RV6 (3D)

Secondary accessions: O60722 P16057 Q12954

Alternative splicing: 2 isoforms: P17948-1 P17948-2 (Additional isoforms seem to exist)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_001153392.1 NP_001153502.1 NP_001153503.1 NP_002010.2

ENSEMBL proteins:

ENSP00000282397

Human Recombinant Proteins

	Invitrogen human recombinant proteins for FLT1
	Millipore Purified and/or Recombinant FLT1 Protein
	Sigma-Aldrich Proteins for FLT1
	R&D Systems Recombinant & Natural Proteins for FLT1 (VEGF R1/Flt-1)
	Enzo Life Sciences proteins for FLT1
	Recombinant Proteins from Abcam (VEGFR 1+VEGFR 2, VEGF Receptor 1)
	Human Recombinant Proteins from Abnova (FLT1)

OriGene Purified Recombinant Human Protein: FLT1

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	TAS	8248162
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	8248162

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Antibodies for FLT1:

	Invitrogen Antibodies for FLT1
	Millipore Mono- and Polyclonal Antibodies for the study of FLT1
	Sigma-Aldrich Antibody Arrays and Antibodies for FLT1
	R&D Systems Antibodies for FLT1 (VEGF R, VEGF R1/Flt-1)
	Cell Signaling Technology (CST) Antibodies for FLT1 (VEGF Receptor 1)
	Antibodies from Abcam (VEGFR 1+VEGFR 2, VEGF Receptor 1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (FLT1)
	Novus Biologicals Antibodies for FLT1

Assays for FLT1:

	Invitrogen Assays for FLT1
	Millipore Kits and Assays for the Analysis of FLT1
	R&D Systems ELISAs for FLT1 (VEGF R1/Flt-1) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P17948

ProtoNet protein and cluster: P17948

5 Blocks protein families:

IPB001824 Receptor tyrosine kinase

IPB003598 Immunoglobulin C-2 type

IPB008266 Tyrosine protein kinase

IPB009134 Vascular endothelial growth factor receptor signature

IPB013098 Immunoglobulin I-set

UniProtKB/Swiss-Prot: VGFR1_HUMAN, P17948

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF

receptor subfamily

Similarity: Contains 7 Ig-like C2-type (immunoglobulin-like) domains

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FLT1)
		Millipore RNAi Products for the Analysis of FLT1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (FLT1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002019

Applied Biosystems Silencer® siRNAs for FLT1

Sigma-Aldrich siRNA and siRNA Panels for FLT1

Sigma-Aldrich shRNA Panels and shRNA for FLT1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FLT1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002019
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002019
untagged cDNA clones in CMV expression vector (see all 2): NM_002019

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002019

UniProtKB/Swiss-Prot: VGFR1_HUMAN, P17948

Function: Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase

ligand/receptor signaling system plays a key role in vascular development and regulation of

vascular permeability. Isoform SFlt1 may have an inhibitory role in angiogenesis

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Enzyme Number (IUBMB): EC 2.7.10.1

Genatlas biochemistry entry for FLT1:

fms-related receptor tyrosine kinase 1,expressed on the surface on endothelial cells

7 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Flt1):

	embryogenesis	immune system	lethality-prenatal/perinatal	normal
reproductive system	vision/eye

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004872	receptor activity	TAS	8248162
GO:0005021	vascular endothelial growth factor receptor activity	TAS	10748050
GO:0005524	ATP binding	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for FLT1 (Your Favorite Gene powered by Ingenuity)

VEGF Signaling
Nitric Oxide Signaling in the Cardiovascular System
IL-8 Signaling
Hepatic Fibrosis / Hepatic Stellate Cell Activation

GeneDecks FLT1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for FLT1

5/89 Interacting proteins for FLT1 (ENSP00000282397³ P17948²) via UniProtKB, MINT, and/or STRING (see all 89 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CBL	P22681²	STRING (score=.993) MINT-6539646 MINT-6539628
LDLR	P01130²	MINT-6177193 MINT-6177086
PLCG1	ENSP00000362369³	STRING (score=.998)
VEGFB	ENSP00000311127³	STRING (score=.998)
HIF1A	ENSP00000338018³	STRING (score=.996)

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5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001569	patterning of blood vessels	IEA	--
GO:0006468	protein amino acid phosphorylation	IEA	--
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	TAS	2158038
GO:0007275	multicellular organismal development	IEA	--
GO:0007565	female pregnancy	TAS	10194760

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for FLT1

Sigma-Aldrich Small Molecules for FLT1:

Inhibitor

Compounds for FLT1 available from Tocris Bioscience
10/24 Novoseek chemical compound relationships for FLT1 gene (see all 24 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	83.35	587	16021077 (9), 17689655 (5), 17346536 (4), 16389038 (4) (see all 99)
matrigel	68.39	10	16447633 (2), 11549592 (2), 15952180 (1), 12382678 (1) (see all 7)
zd6474	67.95	2	18694994 (2)
phosphatidylinositol	31.61	13	10921887 (2), 16946136 (1), 7929439 (1), 11513746 (1) (see all 6)
tgf beta1	29.10	5	16038269 (3), 18512268 (1), 18985316 (1)
wogonin	27.69	4	17024605 (2), 16979123 (2)
thymidine	23.58	1	17006982 (1)
p002	17.80	1	11241411 (1)
nitric oxide	17.37	34	11549592 (5), 11141500 (3), 16006432 (2), 11493335 (2) (see all 16)
ribonucleic acid	15.19	2	16139132 (1), 10523040 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FLT1)
		Millipore RNAi Products for the Analysis of FLT1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (FLT1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002019

Sigma-Aldrich siRNA and siRNA Panels for FLT1

Sigma-Aldrich shRNA Panels and shRNA for FLT1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002019

REFSEQ mRNAs for FLT1 gene (4 alternative transcripts):

NM_001159920.1 NM_001160030.1 NM_001160031.1 NM_002019.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002019

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002019
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002019
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002019

Additional cDNA sequence:

AB209050.1 AF063657.2 AF339822.1 AK292936.1 AK300392.1 AK309901.1 BC029849.1 BC039007.1

BC046165.1 BC048278.1 CR593658.1 CR606445.1 CR611216.1 CR615327.1 DQ836394.1 DQ836395.1

DQ836396.1 EF491868.1 EF491869.1 EF491870.1 EU360600.1 EU368830.1 EU443152.1 EU826561.1

EU826562.1 S77814.1 U01134.1

24/26 DOTS entries (see all 26 ):

DT.455716 DT.100798396 DT.100798389 DT.92439892 DT.120789401 DT.95261500 DT.120789405 DT.444407

DT.100798392 DT.216770 DT.100798393 DT.120789444 DT.95311884 DT.100798394 DT.120789505 DT.202959

DT.40105847 DT.95372174 DT.99979231 DT.86995347 DT.92439882 DT.95372177 DT.97864182 DT.120789450

24/328 AceView cDNA sequences (see all 328 ):

T29349 BC046165 BF061952 CB268312 BM704062 AI692797 AW273133 CD515023

BF515817 BE048969 AI147618 AI800102 AF063657 CR593388 BQ015562 BX504049

BE501454 BC048278 AI088255 AI335834 BX339041 BX382094 CR593658 BX349016

highest scoring ESTs for FLT1:

U01134 AF063657 AL540382 AL543703 AL548841 AL549158 AL551816 AL553307 BC039007 BX336305

Unigene Cluster for FLT1:

Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)

Hs.654360 [show with all ESTs]

Unigene Representative Sequence: NM_002019

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000282397

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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FLT1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FLT1

¹ / ² / ³

21 probe-sets matching FLT1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1963_at²^{, 3}	U95-A	1	1.00	1.00	0.67	0.81	U01134	1.00	1.00	1.00	1
1567_at²^{, 3}	U95-A	1	1.00	1.00	-0.11	1.18	S77812	0.60	1.00	0.82	1
990_at²^{, 3}	U95-A	1	1.00	1.00	0.60	0.73	X51602	0.80	1.00	0.91	1
1545_g_at²^{, 3}	U95-A	1	1.00	1.00	0.75	0.72	S77812	0.60	1.00	0.82	1
56189_at²^{, 3}	U95-B	1	1.00	1.00	0.81	0.95	AA149640	0.60	1.00	0.82	1
991_g_at²^{, 3}	U95-A	1	1.00	1.00	0.08	1.19	X51602	0.80	1.00	0.91	1
1964_g_at²^{, 3}	U95-A	1	1.00	1.00	0.85	1.05	U01134	1.00	1.00	1.00	1
56332_at²^{, 3}	U95-B	2	1.00	0.97	0.89	1.33	AA149648	0.40	1.00	0.76	1
87197_s_at*²^{, 3}	U95-D	1	1.00	1.00	0.02	1.13	AI924499	0.20	1.00	0.72	1
210287_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U01134	1.00	1.00	1.00	1
222033_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AA058828	0.40	1.00	0.76	1
226498_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA149648	0.40	1.00	0.76	1
226497_s_at²^{, 3}	U133-B	2	1.00	0.95	--	--	AA149648	0.40	1.00	0.76	1
232809_s_at*²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
204406_at*²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002019	0.60	1.00	0.82	1
210287_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
222033_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
226498_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
226497_s_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--
232809_s_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204406_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks FLT1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.654360
Expression variation in blood from EXPOLDB for FLT1
UniProtKB/Swiss-Prot: VGFR1_HUMAN, P17948
Tissue specificity: Mostly in normal lung, but also in placenta, liver, kidney, heart and brain
tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in
peripheral blood monocytes. It is not expressed in tumor cell lines. Isoform sFlt1 is strongly
expressed in placenta

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for FLT1 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	FLT1¹	--	fms-related tyrosine kinase 1 (vascular endothelial more	90.3(n) 89.98(a)	403727 XM_534520.2 XP_534520.2
chimpanzee (Pan troglodytes)	FLT1¹	--	fms-related tyrosine kinase 1 (vascular endothelial more	99.43(n) 99.33(a)	452512 XM_509605.2 XP_509605.2
cow (Bos taurus)	FLT1¹	--	fms-related tyrosine kinase 1 (vascular endothelial more	88.32(n) 91.5(a)	503620 XM_001249768.1 XP_001249769.1
rat (Rattus norvegicus)	Flt1¹	--	fms-related tyrosine kinase 1	82.07(n) 82.55(a)	54251 NM_019306.1 NP_062179.1
mouse (Mus musculus)	Flt1^{1, 5}	5 (82.00 cM)⁵	FMS-like tyrosine kinase 1^{1, 5}	81.89(n)¹ 82.12(a)¹	14254¹ NM_010228.3¹ NP_034358.2¹ AF473823⁵ AI323757⁵ (see all 21)

About this table Species with no ortholog for FLT1

ENSEMBL Gene Tree for FLT1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for FLT1 gene

FLT4² KDR²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1212 NCBI SNPs in FLT1 are shown (see all 1212 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 425)

AB	SNP ID	Valid	Chr 13 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs7326277^1,2	A,C,F,H	27774214(+)	`GGGGTT/CTTCCC`	1	--	ng5¹ ese³		7	EU EA WA NA	546
	rs9670212^1,2	A,C,F,H	27968573(+)	`TTCTGC/GTTCAG`	1	--	ng3¹		8	EU EA WA	838
	rs3812867^1,2	A,C,F,H	27774957(+)	`GGTACG/ATGATG`	1	--	ut3¹ ese³		4	EU EA WA	418
	rs664393^1,2	A,C,F,H	27969001(-)	`CAGCCG/ACTTCA`	1	--	ng3¹		9	EU EA WA	2322
	rs35073261^1,2	C,F	27939046(+)	`ACTAAT/GAAATA`	1	L/I	mis¹		4	EU EA WA	418
	rs35832528^1,2	C,F	27794935(+)	`CCTCTT/GCCTCA`	1	A/E	mis¹		4	EU EA WA	420
	rs2296282^1,2	F	27968533(-)	`CCTGCG/AGCTCC`	1	--	ng3¹		1	EA	1488
--	rs17086745^1,2	C	27967272(-)	`CGGCTG/CCTCTT`	1	--	ng3¹		2	MN EA	356
	rs3829380^1,2	H	27774036(+)	`ACCACC/ATTTTT`	1	--	ng5¹		4	EU EA WA	416
	rs17086747^1,2	C	27967675(-)	`TCCGCC/TCCTAG`	1	--	ng3¹ tfbs³		2	MN EA	356

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HapMap Linkage Disequilibrium images for FLT1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 165070

10/91 Novoseek disease relationships for FLT1 gene (see all 91 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
preeclampsia	83.36	192	16021077 (8), 17327029 (6), 18631405 (5), 15993706 (4) (see all 98)
neovascularization	78.51	26	12766257 (1), 17085673 (1), 19265261 (1), 9288799 (1) (see all 21)
tumors	64.55	319	18794121 (5), 14597894 (5), 15699727 (4), 8644848 (4) (see all 99)
intrauterine growth retardation	55.94	8	11675477 (1), 17956955 (1), 16545329 (1), 11945079 (1) (see all 8)
vascular proliferation	55.29	2	10620438 (1), 10077638 (1)
corneal neovascularization	53.52	2	10937562 (1), 15515760 (1)
solid tumor	53.12	1	12526219 (1)
metastasis	50.64	51	17230507 (3), 10620438 (3), 9415339 (2), 18451223 (2) (see all 35)
glioblastoma	49.89	9	15015778 (2), 7525492 (1), 15700836 (1), 7528359 (1) (see all 7)
proteinuria	49.07	10	16458660 (2), 16569734 (1), 16230516 (1), 17127249 (1) (see all 9)

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Human Gene Mutation Database: FLT1
Human Genome Epidemiology Navigator: FLT1 (9 documents)
Tumor Gene Database: FLT1

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/907 PubMed articles for FLT1 gene (see all 907 ):

Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family. (PubMed id 2158038)^{1, 2, 3, 4} Shibuya M....Sato M. (1990)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states. (PubMed id 10543948)^{3, 4} Starovasnik M.A.... Skelton N.J. (1999)
Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules. (PubMed id 9722576)^{3, 4} Ito N.... Claesson-Welsh L. (1998)
Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. (PubMed id 8248162)^{3, 4} Kendall R.L. and Thomas K.A. (1993)
A possible new member of tyrosine kinase family, human frt sequence, is highly conserved in vertebrates and located on human chromosome 13. (PubMed id 3040650)^{3, 4} Matsushime H.... Shibuya M. (1987)
Natural selection of FLT1 alleles and their association with malaria resistance in utero. (PubMed id 18779584)^{1, 3} Muehlenbachs A....Duffy P.E. (2008)
Flt-1, vascular endothelial growth factor receptor 1, is a novel cell surface marker for the lineage of monocyte-macrophages in humans. (PubMed id 11157498)^{1, 3} Sawano A....Shibuya M. (2001)
Dinucleotide repeat polymorphism in Fms-like tyrosine kinase-1 (Flt-1) gene is not associated with preeclampsia. (PubMed id 18631405)^{1, 3} Kim S.Y....Ryu H.M. (2008)
Expression of vascular endothelial growth factor and its receptors KDR and Flt-1 in gastric cancer cells. (PubMed id 12439912)^{1, 3} Zhang H....Shou C.C. (2002)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2321	HGNC: 3763	AceView: FLT1	Ensembl:ENSG00000102755	euGenes: HUgn2321
ECgene: FLT1	H-InvDB: FLT1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for FLT1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for FLT1
(Available from WIS Yeda, Salk, Tufts)

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Licensable Technologies for FLT1 gene:

Weizmann Institute:

Porphyrin and Corrole -like analogs as potent inhibitors of Growth Factor Receptor Binding and Activation

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for FLT1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FLT1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FLT1		Antibodies for FLT1
	Explore super-pooled esiRNAs		Proteins for FLT1
	Lentivirus-delivered shRNAs for FLT1		Small molecules for FLT1
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	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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	Recombinant Proteins (FLT1)
	Antibodies (FLT1)
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Antibodies & Assays for FLT1 (VEGF Receptor 1)

	Recombinant Proteins (VEGFR 1+VEGFR 2, VEGF Receptor 1)
	Antibodies (VEGFR 1+VEGFR 2, VEGF Receptor 1)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for FLT1

	Drugs/Proteins for FLT1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for FLT1

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FLT1 Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for FLT1

Summaries
for FLT1

Genomic Location
for FLT1

Proteins
for FLT1

Protein Domains/
Families
for FLT1

Gene Function
for FLT1

Pathways & Interactions
for FLT1

Drugs & Compounds
for FLT1

Transcripts
for FLT1

Expression
for FLT1

Orthologs
for FLT1

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SNPs/Variants
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Disorders & Mutations
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Medical News
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for FLT1

Search for FLT1

Genome Databases showing FLT1

Other Databases showing FLT1

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Licensable Technologies
for FLT1

Services
for FLT1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FLT1 Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor FLT1

Summariesfor FLT1

Genomic Locationfor FLT1

Proteinsfor FLT1

Protein Domains/Familiesfor FLT1

Gene Functionfor FLT1

Pathways & Interactionsfor FLT1

Drugs & Compoundsfor FLT1

Transcriptsfor FLT1

Expression for FLT1

Orthologsfor FLT1

Paralogsfor FLT1

SNPs/Variantsfor FLT1

Disorders & Mutationsfor FLT1

Medical Newsfor FLT1

Publicationsfor FLT1

Search for FLT1

Genome Databases showing FLT1

Other Databases showing FLT1

Specialized Databases showing FLT1

Licensable Technologiesfor FLT1

Servicesfor FLT1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FLT1

Summaries
for FLT1

Genomic Location
for FLT1

Proteins
for FLT1

Protein Domains/
Families
for FLT1

Gene Function
for FLT1

Pathways & Interactions
for FLT1

Drugs & Compounds
for FLT1

Transcripts
for FLT1

Expression
for FLT1

Orthologs
for FLT1

Paralogs
for FLT1

SNPs/Variants
for FLT1

Disorders & Mutations
for FLT1

Medical News
for FLT1

Publications
for FLT1

Licensable Technologies
for FLT1

Services
for FLT1