Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FLT1 Gene

protein-coding   GIFtS: 76
GCID: GC13M028874

Fms-Related Tyrosine Kinase 1

(Previous name: fms-related tyrosine kinase 1 (vascular endothelial growth...)
(Previous symbol: FLT)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fms-Related Tyrosine Kinase 11 2     Tyrosine-Protein Kinase Receptor FLT2 3
FLT1 2 3     FLT-12 3
Vascular Permeability Factor Receptor1 2 3     VEGFR-12 3
Fms-Related Tyrosine Kinase 1 (Vascular Endothelial Growth Factor/Vascular
Permeability Factor Receptor)1 2
     VEGFR12 3
Vascular Endothelial Growth Factor Receptor 11 2     EC 2.7.10.13 8
Fms-Like Tyrosine Kinase 12 3     FRT3
Tyrosine-Protein Kinase FRT2 3     EC 2.7.108

External Ids:    HGNC: 37631   Entrez Gene: 23212   Ensembl: ENSG000001027557   OMIM: 1650705   UniProtKB: P179483   

Export aliases for FLT1 gene to outside databases

Previous GC identifers: GC13M026854 GC13M022854 GC13M027805 GC13M026673 GC13M027773 GC13M009695


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FLT1 Gene:
This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members
are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven
immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the
cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important
role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells,
placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different
isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and
shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.(provided by
RefSeq, May 2009)

GeneCards Summary for FLT1 Gene: 
FLT1 (fms-related tyrosine kinase 1) is a protein-coding gene. Diseases associated with FLT1 include pre-eclampsia, and microcystic meningioma, and among its related super-pathways are Sorafenib Pharmacodynamics and Focal Adhesion. GO annotations related to this gene include growth factor binding and identical protein binding. An important paralog of this gene is FLT4.

UniProtKB/Swiss-Prot: VGFR1_HUMAN, P17948
Function: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an
essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell
migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative
regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote
endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell
proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells,
proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro).
Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator
of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Likewise, isoforms
lacking a transmembrane domain, such as isoform 2, isoform 3 and isoform 4, may function as decoy receptors for
VEGFA. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of
several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules
diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation
of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol
kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase
signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also
phosphorylate CBL. Isoform 1 phosphorylates PLCG. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes
phosphorylation of PTK2/FAK1. Isoform 7 has a truncated kinase domain; it increases phosphorylation of SRC at
'Tyr-418' by unknown means and promotes tumor cell invasion

summary for FLT1 Gene:
Vascular endothelial growth factor is a signaling protein involved in the regulation of angiogenesis and
vasculogenesis. VEGF binds to and activates a receptor tyrosine kinase, VEGFR. Three VEGFR isoforms have
been identified in humans; VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1) and VEGFR-3 (Flt-4). VEGFR-2 mediates the
majority of cellular responses to VEGF. VEGFR-1 is thought to modulate VEGFR-2 signaling or to act as a
dummy/decoy receptor to sequester VEGF away from VEGFR-2.

Gene Wiki entry for FLT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FLT1 gene promoter:
         STAT1   AP-1   ATF-2   STAT1beta   c-Jun   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFLT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for FLT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FLT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12   Ensembl cytogenetic band:  13q12.3   HGNC cytogenetic band: 13q12

FLT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FLT1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M028874:  view genomic region     (about GC identifiers)

Start:
28,874,483 bp from pter      End:
29,069,265 bp from pter
Size:
194,783 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: VGFR1_HUMAN, P17948 (See protein sequence)
Recommended Name: Vascular endothelial growth factor receptor 1 precursor  
Size: 1338 amino acids; 150769 Da
Subunit: Interacts with VEGFA, VEGFB and PGF. Monomer in the absence of bound VEGFA, VEGFB or PGF. Homodimer in
the presence of bound VEGFA, VEGFB and PGF. Can also form a heterodimer with KDR. Interacts (when tyrosine
phosphorylated) with CBL, CRK, GRB2, NCK1, PIK3R1, PLCG, PSEN1 and PTPN11. Probably interacts also with PTPRB.
Interacts with GNB2L1/RACK1. Identified in a complex with CBL and CD2AP
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Endosome.
Note=Autophosphorylation promotes ubiquitination and endocytosis
Subcellular location: Isoform 2: Secreted
Subcellular location: Isoform 3: Secreted
Subcellular location: Isoform 4: Secreted
Subcellular location: Isoform 5: Cytoplasm (Potential)
Subcellular location: Isoform 6: Cytoplasm (Potential)
Subcellular location: Isoform 7: Cytoplasm (Potential)
6/7 PDB 3D structures from and Proteopedia for FLT1 (see all 7):
1FLT (3D)        1QSV (3D)        1QSZ (3D)        1QTY (3D)        1RV6 (3D)        2XAC (3D)    
Secondary accessions: A3E342 A3E344 A8KA71 B0LPF1 B2BF46 B2BF47 B3FR89 B5A923 F5H5L6 O60722
P16057 Q12954
Alternative splicing: 7 isoforms:  P17948-1   P17948-2   P17948-3   P17948-4   P17948-5   P17948-6   P17948-7   

Explore the universe of human proteins at neXtProt for FLT1: NX_P17948

Explore proteomics data for FLT1 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • UniProtKB: Ubiquitinated after VEGFA-mediated autophosphorylation, leading to proteolytic degradation
  • UniProtKB: Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit
    of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-1169 is
    important for interaction with PLCG. Phosphorylation at Tyr-1213 is important for interaction with PIK3R1,
    PTPN11, GRB2, and PLCG. Phosphorylation at Tyr-1333 is important for endocytosis and for interaction with CBL,
    NCK1 and CRK. Is probably dephosphorylated by PTPRB
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P17948

  • 4/22 DME Specific Peptides for FLT1 (P17948) (see all 22)
     QVARGME  RDLAARN  WEIFSLG  VAVKMLK 

    FLT1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FLT1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001153392.1  NP_001153502.1  NP_001153503.1  NP_002010.2  

    ENSEMBL proteins: 
     ENSP00000282397   ENSP00000443311   ENSP00000437841   ENSP00000437631   ENSP00000442630  
    Reactome Protein details: P17948
    Human Recombinant Protein Products for FLT1: 
    EMD Millipore Purified and/or Recombinant FLT1 Protein
    R&D Systems Recombinant & Natural Proteins for FLT1 (VEGF R1/Flt-1)
    Enzo Life Sciences proteins for FLT1
    OriGene Purified Protein for FLT1
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for FLT1 
    OriGene Custom Protein Services for FLT1
    GenScript Custom Purified and Recombinant Proteins Services for FLT1
    Novus Biologicals FLT1 Proteins
    Novus Biologicals FLT1 Lysates
    Sino Biological Recombinant Protein for FLT1
    Sino Biological Cell Lysate for FLT1 
    ProSpec Recombinant Protein for FLT1
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS8248162
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005768endosome IEA--

    FLT1 for ontologies           About GeneDecksing



    FLT1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of FLT1
    R&D Systems Antibodies for FLT1 (VEGF R1/Flt-1)
    Cell Signaling Technology (CST) Antibodies for FLT1  (VEGFR1)
    OriGene Antibodies for FLT1
    OriGene Custom Antibody Services for FLT1
    GenScript Custom Superior Antibodies Services for FLT1
    Novus Biologicals FLT1 Antibodies
    Abcam antibodies for FLT1
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for FLT1
    LSBio Antibodies in human, mouse, rat for FLT1 

    Assay Products for FLT1: 
    EMD Millipore Kits and Assays for the Analysis of FLT1
    OriGene Custom Assay Services for FLT1
    R&D Systems ELISAs for FLT1 (VEGF R1/Flt-1)         (see all)
    GenScript FLT1-Activity-based Kinase Assay for Compound Screening
    Enzo Life Sciences assays for FLT1
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: fms-related tyrosine kinase 1 
    VEGF (vascular endothelial growth factor) receptor family
    VEGF (vascular endothelial growth factor) receptor family

    5/14 InterPro protein domains (see all 14):
     IPR003598 Ig_sub2
     IPR017441 Protein_kinase_ATP_BS
     IPR013098 Ig_I-set
     IPR011009 Kinase-like_dom
     IPR009134 Tyr_kinase_VEGFR_rcpt_N

    Graphical View of Domain Structure for InterPro Entry P17948

    ProtoNet protein and cluster: P17948

    5 Blocks protein domains:
    IPB001824 Receptor tyrosine kinase
    IPB003598 Immunoglobulin C-2 type
    IPB008266 Tyrosine protein kinase
    IPB009134 Vascular endothelial growth factor receptor signature
    IPB013098 Immunoglobulin I-set


    UniProtKB/Swiss-Prot: VGFR1_HUMAN, P17948
    Domain: The second and third Ig-like C2-type (immunoglobulin-like) domains are sufficient for VEGFA binding
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily
    Similarity: Contains 7 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 protein kinase domain


    FLT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VGFR1_HUMAN, P17948
    Function: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an
    essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell
    migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative
    regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote
    endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell
    proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells,
    proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro).
    Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator
    of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Likewise, isoforms
    lacking a transmembrane domain, such as isoform 2, isoform 3 and isoform 4, may function as decoy receptors for
    VEGFA. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of
    several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules
    diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation
    of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol
    kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase
    signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also
    phosphorylate CBL. Isoform 1 phosphorylates PLCG. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes
    phosphorylation of PTK2/FAK1. Isoform 7 has a truncated kinase domain; it increases phosphorylation of SRC at
    'Tyr-418' by unknown means and promotes tumor cell invasion
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Present in an inactive conformation in the absence of bound ligand. Binding of VEGFA, VEGFB or
    PGF leads to dimerization and activation by autophosphorylation on tyrosine residues
    Induction: Up-regulated in coculture of VSMC/endothelial cell (EC) or by direct exposure to VEGF of VSMC
    monoculture. Up-regulated from the second trimester of pregnancy to the term and in the placenta of women with
    preeclampsia (PE). Up-regulated in monocytes exposed to bacterial lipopolysaccharide (LPS)

         Genatlas biochemistry entry for FLT1:
    fms-related receptor tyrosine kinase 1,expressed on the surface on endothelial cells

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004714transmembrane receptor protein tyrosine kinase activity TAS8248162
    GO:0005021vascular endothelial growth factor-activated receptor activity IMP11312102
    GO:0005515protein binding IPI10543948
         
    FLT1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FLT1:
     Increased cell death in HCC-19  Increased colony dispersion (i 

         14 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Flt1):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  muscle 
     nervous system  normal  reproductive system  vision/eye 

    FLT1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FLT1: Flt1tm2Msh Flt1tm1Msh

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FLT1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FLT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FLT1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FLT1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FLT1
    8/119 QIAGEN miScript miRNA Assays for microRNAs that regulate FLT1 (see all 119):
    hsa-miR-323-3p hsa-miR-548j hsa-miR-549 hsa-miR-607 hsa-miR-106a hsa-miR-4272 hsa-miR-605 hsa-miR-1258
    SwitchGear 3'UTR luciferase reporter plasmidFLT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FLT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FLT1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FLT1
    Sirion Biotech Customized adenovirus for overexpression of FLT1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for FLT1 (see all 21)
    OriGene ORF clones in mouse, rat for FLT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): FLT1 (NM_001159920)
    Sino Biological Human cDNA Clone for FLT1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FLT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLT1
    Sirion Biotech Customized lentivirus for stable overexpression of FLT1 
                         Customized lentivirus expression plasmids for stable overexpression of FLT1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FLT1
    Search LifeMap BioReagents cell lines for FLT1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLT1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FLT1 About   (see all 37)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Sorafenib Pharmacodynamics
    Sorafenib Pharmacodynamics0.37
    VEGF Pathway0.36
    Vemurafenib Pathway, Pharmacodynamics0.37
    2Focal Adhesion
    Focal Adhesion0.64
    Focal adhesion0.64
    3PEDF Induced Signaling
    Endothelin-1 Signaling Pathway0.46
    Cytokine-cytokine receptor interaction0.43
    4VEGF Family Ligands and Receptor Interactions
    VEGF Family Ligands and Receptor Interactions0.66
    Development VEGF-family signaling0.36
    5VEGF Signaling Pathway
    VEGF Signaling Pathway0.34
    VEGF Signaling0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for FLT1
        Development VEGF-family signaling
    Transcription P53 signaling pathway

    1 R&D Systems Pathway for FLT1
        Akt Signaling Pathway

    5/56 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FLT1 (see all 56)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for FLT1
        Angiogenesis
    Tyrosine Kinases / Adaptors

    4 Tocris Bioscience Pathways for FLT1
        Akt Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    VEGF Pathway

    2 GeneGo (Thomson Reuters) Pathways for FLT1
        Development VEGF-family signaling
    Transcription P53 signaling pathway

    5/8 BioSystems Pathways for FLT1 (see all 8)
        Angiogenesis
    Focal Adhesion
    Id Signaling Pathway
    Glypican 1 network
    S1P3 pathway

    1 Sino Biological Pathway for FLT1 
        VEGF Signaling

    5        Reactome Pathways for FLT1
        Signaling by VEGF
    VEGF binds to VEGFR leading to receptor dimerization
    VEGF ligand-receptor interactions
    Signal Transduction
    Neurophilin interactions with VEGF and VEGFR

    3 PharmGKB Pathways for FLT1
        Sorafenib Pharmacodynamics
    VEGF Signaling Pathway
    Vemurafenib Pathway, Pharmacodynamics

    5/7         Kegg Pathways  (Kegg details for FLT1) (see all 7):
        Cytokine-cytokine receptor interaction
    HIF-1 signaling pathway
    Endocytosis
    PI3K-Akt signaling pathway
    Focal adhesion


    FLT1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FLT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/80 Interacting proteins for FLT1 (P179481, 2, 3 ENSP000002823974) via UniProtKB, MINT, STRING, and/or I2D (see all 80)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPRBP234672, 3, ENSP000003349284MINT-8277647 MINT-8277600 I2D: score=1 STRING: ENSP00000334928
    PLCG1P191741, 3, ENSP000002440074EBI-1026718,EBI-79387 I2D: score=5 STRING: ENSP00000244007
    PIK3R1P279862, 3, ENSP000002743354MINT-8038003 I2D: score=3 STRING: ENSP00000274335
    PTPN11Q061241, 3, ENSP000003409444EBI-1026718,EBI-297779 I2D: score=3 STRING: ENSP00000340944
    CBLP226812, 3, ENSP000002640334MINT-6539646 MINT-6539628 I2D: score=3 STRING: ENSP00000264033
    About this table

    Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001569patterning of blood vessels IEA--
    GO:0002040sprouting angiogenesis IEA--
    GO:0002548monocyte chemotaxis IDA18079407
    GO:0006468protein phosphorylation ----
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway TAS2158038

    FLT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FLT1 for compounds           About GeneDecksing

    EMD Millipore small molecules for FLT1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for FLT1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Ki 8751 Potent, selective VEGFR-2 inhibitor [228559-41-9]
    ZM 323881 hydrochloride Potent, selective inhibitor of VEGFR-2 [324077-30-7]
    Axitinib Potent VEGFR-1, -2 and -3 inhibitor [319460-85-0]
    DMH4Selective VEGFR-2 inhibitor[515880-75-8]
    ZM 306416 hydrochlorideInhibitor of VEGF receptor tyrosine kinase[690206-97-4]

    2 HMDB Compounds for FLT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    6 DrugBank Compounds for FLT1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Sorafenib-- 284461-73-0targetinhibitor16507829 17016424 15466206
    SunitinibSU011248 (see all 2)557795-19-4targetantagonist17367763 14654525
    Axitinib-- 319460-85-0targetinhibitor18541897
    N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide-- --target--10592235
    PazopanibGW-786034 (see all 2)444731-52-6targetinhibitor17288876
    Regorafenib-- 755037-03-7targetinhibitor--

    2 IUPHAR Ligands for FLT1 (fms-related tyrosine kinase 1)    About this table 
    LigandTypeActionAffinityPubmed IDs
    VEGFA
    NoneNone--
    VEGFB
    NoneNone--

    10/44 Novoseek inferred chemical compound relationships for FLT1 gene (see all 44)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 96.1 2072 12560388 (9), 10440746 (8), 10620438 (7), 11908876 (7) (see all 99)
    tyrosine 84.4 701 16021077 (9), 19943826 (8), 17689655 (5), 20223446 (4) (see all 99)
    matrigel 69.2 10 16447633 (2), 11549592 (2), 15952180 (1), 12382678 (1) (see all 7)
    ptk787 68.3 1 10882357 (1)
    zd6474 64.8 2 18694994 (2)
    su5416 53.9 6 12489845 (3), 15001553 (1), 17169805 (1)
    sunitinib 53.1 3 18036049 (1), 17367763 (1), 20335444 (1)
    tgf beta1 31 5 16038269 (3), 18512268 (1), 18985316 (1)
    phosphatidylinositol 29.1 13 10921887 (2), 16946136 (1), 7929439 (1), 11513746 (1) (see all 6)
    wogonin 24.1 4 17024605 (2), 16979123 (2)

    Search CenterWatch for drugs/clinical trials and news about FLT1 / VGFR1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FLT1 gene (4 alternative transcripts): 
    NM_001159920.1  NM_001160030.1  NM_001160031.1  NM_002019.4  

    Unigene Cluster for FLT1:

    Fms-related tyrosine kinase 1
    Hs.594454  [show with all ESTs]
    Unigene Representative Sequence: NM_002019
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000282397(uc010aap.2 uc010aaq.2 uc001usa.3 uc001usb.3)
    ENST00000540678 ENST00000543394 ENST00000541932(uc010aar.1 uc001usc.3 uc010aas.1 uc010aat.1)
    ENST00000539099(uc010tdp.1 uc001usd.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FLT1
    8/119 QIAGEN miScript miRNA Assays for microRNAs that regulate FLT1 (see all 119):
    hsa-miR-323-3p hsa-miR-548j hsa-miR-549 hsa-miR-607 hsa-miR-106a hsa-miR-4272 hsa-miR-605 hsa-miR-1258
    SwitchGear 3'UTR luciferase reporter plasmidFLT1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FLT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FLT1
    Clone
    Products:
         
    OriGene clones in human, mouse for FLT1 (see all 21)
    OriGene ORF clones in mouse, rat for FLT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): FLT1 (NM_001159920)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FLT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLT1
    Sirion Biotech Customized lentivirus for stable overexpression of FLT1 
                         Customized lentivirus expression plasmids for stable overexpression of FLT1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FLT1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FLT1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FLT1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FLT1

    Additional mRNA sequence: 

    AB209050.1 AF063657.2 AF339822.1 AK092472.1 AK292936.1 AK300392.1 AK309901.1 BC029849.1 
    BC039007.1 BC046165.1 BC048278.1 DQ836394.1 DQ836395.1 DQ836396.1 EF484674.1 EF491868.1 
    EF491869.1 EF491870.1 EU360600.1 EU368830.1 EU443152.1 EU826561.1 EU826562.1 JF509744.1 
    JF509745.1 S77814.1 U01134.1 

    24/28 DOTS entries (see all 28):

    DT.444407  DT.455716  DT.100798396  DT.92439892  DT.100798389  DT.120789401  DT.95261500  DT.120789405 
    DT.100798392  DT.91763065  DT.216770  DT.100798393  DT.120789444  DT.95311884  DT.100798394  DT.120789505 
    DT.202959  DT.40105847  DT.95372174  DT.86995347  DT.92439882  DT.95372177  DT.97864182  DT.120789450 

    24/328 AceView cDNA sequences (see all 328):

    AI692797 CD360040 BG434987 BF059533 AA369424 BF061952 BM704062 CR606445 
    BC048278 CR593388 BE501454 AA128168 CA976089 AA257133 T29349 AI335834 
    BF515817 AI090219 CR619240 AI088255 CA394920 CD515023 BM681260 CR615327 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FLT1 expression in normal human tissues (normalized intensities)      FLT1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FLT1 Expression
    About this image


    FLT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/19 selected tissues (see all 19) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 25 entries
             Hypertrophic Chondrocytes Stylopod Growth Plate
             Bone marrow-derived adherent progenitor cells (MultiStem)
     
     Cartilage (Muscoskeletal System)    fully expand to see all 20 entries
             Intervertebral Disc Nucleus Pulposus Cells Sacral Intervertebral Disc
     
     Endothelium (Cardiovascular System)    fully expand to see all 13 entries
             Arterial Endothelial Cells Paired Dorsal Aorta
             PureStem endothelial progenitor RP1-MV2-18
             Endothelial-like cells ( Derivation and purification of endothelial precursor cells...
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 7 entries
             Primitive Cytotrophoblast Cells Chorion Frondosum
     
     Heart (Cardiovascular System)    fully expand to see all 5 entries
             Primitive Heart Tube Cells Primitive Heart Tube
             Heart Tube
             Cardiac progenitor cells
             left ventricular apex samples   

    See FLT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FLT1

    SOURCE GeneReport for Unigene cluster: Hs.594454

    UniProtKB/Swiss-Prot: VGFR1_HUMAN, P17948
    Tissue specificity: Detected in normal lung, but also in placenta, liver, kidney, heart and brain tissues.
    Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood
    monocytes. Isoform 2 is strongly expressed in placenta. Isoform 3 is expressed in corneal epithelial cells (at
    protein level). Isoform 3 is expressed in vascular smooth muscle cells (VSMC)

        SABiosciences Expression via Pathway-Focused PCR Arrays including FLT1 (see all 10): 
              Osteogenesis in human mouse rat
              Cancer PathwayFinder in human mouse rat
              VEGF Signaling in human mouse rat
              Liver Cancer in human mouse rat
              Angiogenesis in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FLT1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FLT1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FLT1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FLT1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FLT1 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Flt11 , 5 FMS-like tyrosine kinase 11, 5 81.89(n)1
    82.12(a)1
      5 (87.01 cM)5
    142541  NM_010228.31  NP_034358.21 
     1475616045 
    chicken
    (Gallus gallus)
    Aves FLT11 fms-related tyrosine kinase 1 (vascular endothelial more 72.85(n)
    70.23(a)
      374100  NM_204252.1  NP_989583.1 
    lizard
    (Anolis carolinensis)
    Reptilia FLT16
    fms-related tyrosine kinase 1
    65(a)
    1 ↔ 1
    3(185650783-185772043)
    zebrafish
    (Danio rerio)
    Actinopterygii AY056466.12   -- 75.94(n)   58106  AY056466.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta tor3
    Pvr1
    eggshell pattern formation
    transmembrane receptor more3
    PDGF- and VEGF-receptor related1
    46(a)
    (best of 2)3
    43.73(n)1
    31.97(a)1
      43E123
    341271  NM_001169438.11  NP_001162909.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y50D4B.61 , 3 Protein Y50D4B.61 43(a)
    (best of 5)3
    52.38(n)1
    47.2(a)1
      V(1083951-1086950)3
    35655931  NM_070974.31  NP_503375.21 


    ENSEMBL Gene Tree for FLT1 (if available)
    TreeFam Gene Tree for FLT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FLT1 gene
    FLT42  FGFR42  PDGFRB2  CSF1R2  KIT2  FGFR32  PDGFRA2  RET2  
    KDR2  FGFR12  FGFR22  FLT32  
    18/60 SIMAP similar genes for FLT1 using alignment to 6 protein entries:     VGFR1_HUMAN (see all proteins) (see all similar genes):
    KIT    RET    FGFR2    ABL1    FGFR1    FLT4
    FGFR3    R11    R12    TIE1    LTK    CCDC6-RETa
    CCDC6-RETc    urf-ret    EZR-ROS1    LRIG3(NM_001136051)-ROS1    LRIG3(NM_153377)-ROS1    R32

    FLT1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FLT1
    PGOHUM00000237611


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4324 SNPs in FLT1 are shown (see all 4324)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0420494
    A glioma low grade oligodendroglioma sample4--see VAR_0420492 R Q mis40--------
    VAR_0420484
    A lung adenocarcinoma sample4--see VAR_0420482 L I mis40--------
    VAR_0420524
    A bladder transitional cell carcinoma sample4--see VAR_0420522 L V mis40--------
    rs105916911,2
    C--9708996(+) aaaaa-/A/A   
       A
    /GAG
    gaaga
    2 -- int1 cds11NA 2
    rs673995901,2
    C--9722860(-) CCTCC-/TTTT  
      
    /TTTTT
    TTTTT
    1 -- int11NA 2
    rs578027831,2
    C--9741649(+) AAAAA-/A/    
       AAAGA
    TGTGG
    1 -- int11NA 2
    rs341550461,2
    C--9748660(+) GTCTC-/AAAAAA 1 -- int10--------
    rs588242971,2
    C--9748677(+) AAAAA-/A/AA  
            
    GAATG
    1 -- int11NA 2
    rs1425347651,2
    C--9767109(+) CATTG-/GTGTGTG 2 -- int10--------
    rs116170071,2
    C,H--9767137(+) tgtgtA/Gtatat 2 -- int10--------

    HapMap Linkage Disequilibrium report for FLT1 (28874483 - 29069265 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FLT1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv455850CNV Loss19166990
    esv34052CNV Loss18971310


    Human Gene Mutation Database (HGMD): FLT1

    Locus Specific Mutation Databases (LSDB): FLT1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FLT1
    DNA2.0 Custom Variant and Variant Library Synthesis for FLT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 165070    OMIM disorders: --

    UniProtKB/Swiss-Prot: VGFR1_HUMAN, P17948
  • Note=Can contribute to cancer cell survival, proliferation, migration, and invasion, and tumor
    angiogenesis and metastasis. May contribute to cancer pathogenesis by promoting inflammatory responses and
    recruitment of tumor-infiltrating macrophages
  • Note=Abnormally high expression of soluble isoforms (isoform 2, isoform 3 or isoform 4) may be a cause of
    preeclampsia

  • 20/162 diseases for FLT1 (see all 162):    About MalaCards
    pre-eclampsia    microcystic meningioma    eclampsia    lipodermatosclerosis
    cancer-associated retinopathy    placental insufficiency    malaria, resistance to    epithelioid hemangioendothelioma
    corneal neovascularization    acute mountain sickness    arteriovenous malformation    myxofibrosarcoma
    angiosarcoma    rosacea    bronchopulmonary dysplasia    chorioamnionitis
    diabetic retinopathy    hemangioblastoma    pilocytic astrocytoma    hemangioendothelioma

    6 diseases from the University of Copenhagen DISEASES database for FLT1:
    pre-eclampsia     Cancer     Proteinuria     Diabetic retinopathy
    Retinopathy of prematurity     Age related macular degeneration

    FLT1 for disorders           About GeneDecksing

    10/91 Novoseek inferred disease relationships for FLT1 gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    preeclampsia 85.1 223 16021077 (8), 17327029 (6), 18631405 (5), 15993706 (4) (see all 99)
    neovascularization 78.4 33 20298529 (2), 12766257 (1), 17085673 (1), 19265261 (1) (see all 25)
    tumors 65.4 348 18794121 (5), 14597894 (5), 15699727 (4), 8644848 (4) (see all 99)
    proteinuria 56.3 14 16458660 (2), 19996068 (1), 19485913 (1), 16569734 (1) (see all 13)
    intrauterine growth retardation 56.2 9 11675477 (1), 17956955 (1), 16545329 (1), 11945079 (1) (see all 9)
    vascular proliferation 53.2 2 10620438 (1), 10077638 (1)
    solid tumor 52.8 1 12526219 (1)
    metastasis 52.3 59 17230507 (3), 10620438 (3), 19689271 (3), 9415339 (2) (see all 38)
    glioblastoma 51.4 11 15015778 (2), 7525492 (1), 15700836 (1), 12451475 (1) (see all 9)
    corneal neovascularization 50.8 2 10937562 (1), 15515760 (1)

    Genetic Association Database (GAD): FLT1
    Human Genome Epidemiology (HuGE) Navigator: FLT1 (29 documents)
    Tumor Gene Database (TGDB): FLT1

    Export disorders for FLT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FLT1 gene, integrated from 9 sources (see all 1210):
    (articles sorted by number of sources associating them with FLT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family. (PubMed id 2158038)1, 2, 3, 9 Shibuya M....Sato M. (1990)
    2. Natural selection of FLT1 alleles and their association with malaria resistance in utero. (PubMed id 18779584)1, 4, 9 Muehlenbachs A....Duffy P.E. (2008)
    3. Dinucleotide repeat polymorphism in Fms-like tyrosine kinase-1 (Flt-1) gene is not associated with preeclampsia. (PubMed id 18631405)1, 4, 9 Kim S.Y....Ryu H.M. (2008)
    4. The phosphorylated 1169-tyrosine containing region of flt-1 kinase (VEGFR-1) is a major binding site for PLCgamma. (PubMed id 9299537)1, 2, 9 Sawano A....Shibuya M. (1997)
    5. Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells. (PubMed id 15735759)1, 2, 9 Fan F....Ellis L.M. (2005)
    6. Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor. (PubMed id 9393862)1, 2, 9 Wiesmann C....de Vos A.M. (1997)
    7. Mutation analysis of the growth factor genes PlGF, Fl t1, IGF-I, and IGF-IR in intrauterine growth restriction with abnormal placenta l blood flow. (PubMed id 19658040)1, 4, 9 Muetze S....Rudnik-Schoeneborn S. (2009)
    8. Angiogenesis in systemic sclerosis: impaired expression of vascular endothelial growth factor receptor 1 in endothelial progenitor-derived cells under hypoxic conditions. (PubMed id 18975312)1, 4, 9 Avouac J....Allanore Y. (2008)
    9. A novel intracellular isoform of VEGFR-1 activates Sr c and promotes cell invasion in MDA-MB-231 breast cancer cells. (PubMed id 20512933)1, 2, 9 Mezquita B....Mezquita C. (2010)
    10. Allelic variations in angiogenic pathway genes are as sociated with preeclampsia. (PubMed id 20223440)1, 4, 9 Srinivas S.K....Elovitz M.A. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2321 HGNC: 3763 AceView: FLT1 Ensembl:ENSG00000102755 euGenes: HUgn2321
    ECgene: FLT1 Kegg: 2321 H-InvDB: FLT1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FLT1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FLT1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FLT1 gene:
    Search GeneIP for patents involving FLT1

    Licensable Technologies for FLT1 gene:
    Weizmann Institute:Porphyrin and Corrole -like analogs as potent inhibitors of Growth Factor Receptor Binding and Activation
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Kits and Assays for the Analysis of FLT1
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Purified and/or Recombinant FLT1 Protein
     EMD Millipore Mono- and Polyclonal Antibodies for the study of FLT1
     EMD Millipore small molecules (inhibitor) for FLT1
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for FLT1 (VEGF R1/Flt-1)   Browse Cell Culture Products  
     ELISAs for FLT1 (VEGF R1/Flt-1)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for FLT1 (VEGF R1/Flt-1)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     cDNA Clones for FLT1 (VEGF R1/Flt-1)   Proteome Profiler Antibody Arrays for FLT1 (VEGF R1/Flt-1)  
     OriGene Antibodies for FLT1   OriGene RNAi products in human, mouse, rat for FLT1  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene MassSpec something-or-other for FLT1   OriGene clones in human, mouse for FLT1  
     OriGene qSTAR qPCR primer pairs in human, mouse for FLT1   OriGene Purified Protein for FLT1  
     OriGene ORF clones in mouse, rat for FLT1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FLT1   OriGene Custom Protein Services for FLT1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FLT1
     QIAGEN SeqTarget long-range PCR primers for resequencing FLT1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FLT1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FLT1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FLT1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FLT1
     GenScript Custom Purified and Recombinant Proteins Services for FLT1 GenScript cDNA clones with any tag delivered in your preferred vector for FLT1
     GenScript FLT1-Activity-based Kinase Assay for Compound Screening GenScript Custom Superior Antibodies Services for FLT1
     GenScript Custom overexpressing Cell Line Services for FLT1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for FLT1  (VEGFR1)

     Regulatory tfbs in FLT1 promoter
     Search Chromatin IP Primers for FLT1
     RT2 qPCR Primer Assay in human, mouse, rat FLT1
     GNC Network for FLT1
     SABiosciences PCR Arrays including human, mouse, rat FLT1
     Tocris compounds for FLT1
     Proteins and Antibodies for FLT1
     Cell Lysates for FLT1
     cDNA Clones for FLT1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Assays/Proteins for FLT1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FLT1 antibodies
     FLT1 proteins
     FLT1 lysates
     Antibodies for FLT1
     See all of Abcam's Antibodies, Kits and Proteins for FLT1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for FLT1




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for FLT1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLT1
     SwitchGear 3'UTR luciferase reporter plasmids for FLT1
     SwitchGear Promoter luciferase reporter plasmids for FLT1
     ThermoFisher Antibody for FLT1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLT1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for FLT1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FLT1
    Customized:
     lentivirus for stable overexpression of FLT1
     lentivirus expression plasmids for stable overexpression of FLT1
     adenovirus for overexpression of FLT1
     LSBio Antibodies in human, mouse, rat for FLT1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FLT1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4