FLRT3 Gene

Aliases
for FLRT3 gene

Previous GC identifers: GC20M014292 GC20M014298 GC20M014299

Summaries
for FLRT3 gene

Genomic Views
for FLRT3 gene

RefSeq DNA sequence:

NC_000020.10  NC_018931.1  NT_011387.8  

SwitchGear Promoter luciferase reporter plasmid: FLRT3 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FLRT3

FLRT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M014251:  view genomic region     (about GC identifiers)

Proteins
for FLRT3 gene

Explore the universe of human proteins at neXtProt for FLRT3: NX_Q9NZU0

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for FLRT3
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: FLRT3 Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for FLRT3
	GenScript Custom Purified and Recombinant Proteins Services for FLRT3
	Sino Biological Recombinant Protein for FLRT3
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for FLRT3

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for FLRT3
	Browse OriGene Antibodies OriGene Custom Antibody Services for FLRT3
	GenScript Custom Superior Antibodies Services for FLRT3
	Search for Antibodies for FLRT3 at Abcam
	Uscn Antibodies for FLRT3
	Search ThermoFisher Antibodies for FLRT3

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for FLRT3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FLRT3

Protein Domains /
Families
for FLRT3 gene

ProtoNet protein and cluster: Q9NZU0

Function
for FLRT3 gene

miRNA Products:		OriGene 3'-UTR Clone (see all 2): FLRT3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FLRT3
		8/75 QIAGEN miScript miRNA Assays for microRNAs that regulate FLRT3 (see all 75):
		hsa-miR-124* hsa-miR-548j hsa-miR-193a-3p hsa-miR-300 hsa-miR-199a-3p hsa-miR-128 hsa-miR-219-5p hsa-miR-4325
		SwitchGear 3'UTR luciferase reporter plasmid: FLRT3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FLRT3 (see all 7) OriGene shRNA RFP: FLRT3 OriGene siRNA: FLRT3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FLRT3

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for FLRT3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FLRT3 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FLRT3 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): FLRT3 (NM_198391)
		Sino Biological Human cDNA Clone for FLRT3
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FLRT3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLRT3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FLRT3
		Search LifeMap BioReagents cell lines for FLRT3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLRT3

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 3 alleles) (MGI details for Flrt3)

Pathways & Interactions
for FLRT3 gene

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for FLRT3 gene

Transcripts
for FLRT3 gene

Expression
for FLRT3 gene

FLRT3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTTTTCTA

5 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BrainBlood Brain BarrierEndothelial Cells			Blood Brain Barrier, Endothelium
	LungTracheaBasal Cells			Lung
	Neural TubeDiencephalic Ventricular Zone			Neural Tube
	Neural TubeMesencephalic Ventricular Zone			Neural Tube
	Neural TubeTelencephalon			Neural Tube
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 10/13 LifeMap Cells (see all 13)
	Name			Category
	PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)			Blood, Endothelium
	PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)			Heart, Myocardium, Smooth Muscle
	PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)			Adipose, Bone, Cartilage
	PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)			Endothelium
	PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
	Syncytiotrophoblast-like cells (Generation of syncyt...)
	Mesendoderm-like cells (Generation of mesend...)
	Definitive Endoderm (Generation of beta c...)
	Extraembryonic endoderm-like cells (Generation of extrae...)
	Mesoderm-like cells (Derivation of cardio...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FLRT3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FLRT3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FLRT3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FLRT3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLRT3

Orthologs
for FLRT3 gene

Paralogs
for FLRT3 gene

Paralogs for FLRT3 gene

GP5²  FLRT1²  CPN2²  LRIG3²  LRRTM4²  CHAD²  LRRC15²  LRIG2²  

LRRTM3²  IGFALS²  CHADL²  LRIG1²  LRRTM2²  FLRT2²  VASN²  LRRTM1²  

2 SIMAP similar genes for FLRT3 using alignment to 1 protein entry:     FLRT3_HUMAN:

FLRT1    FLRT2

FLRT3 for paralogs           About GeneDecksing

Genomic Variants
for FLRT3 gene

10/246 NCBI SNPs in FLRT3 are shown (see all 246)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1444863851,2		--	14304186(+)	ACTTAA/GTCTTC	3	--	int1 ds5001		0	--	--	--	--
rs1389766781,2		--	14304279(+)	AGACTC/TTATCT	3	--	ds5001 int1		0	--	--	--	--
rs1134296711,2		--	14304326(+)	CATTAG/ACATAT	3	--	ds5001 int1		1		CSA	2
rs1866016951,2		--	14304386(+)	GAAACA/CGGGAC	3	--	ds5001 int1		0	--	--	--	--
rs1926551381,2		--	14304558(+)	CATCTA/GTACAG	3	--	ds5001 int1		0	--	--	--	--
rs792954871,2	C,F,	--	14304700(+)	GGGACG/ATTTAG	3	--	ut31 int1		1		WA	118
rs1397385731,2		--	14304712(+)	ACTAAC/TGTGCT	3	--	ut31 int1		0	--	--	--	--
rs755344661,2		--	14304731(+)	TGCTAC/TTTAGT	3	--	int1 ut31		1		NA	120
rs60426701,2	H,	--	14304759(+)	GAAAAA/GGCAAG	3	--	int1 ut31		1		NS	120
rs1830803381,2		--	14304785(+)	CTTTTA/TAAAAG	3	--	int1 ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for FLRT3 (14303634 - 14318313 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for FLRT3: --

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FLRT3

DNA2.0 Custom Variant and Variant Library Synthesis for FLRT3

Disorders / Diseases
for FLRT3 gene

Publications
for FLRT3 gene

PubMed articles for FLRT3 gene, integrated from 9 sources (see all 16): (articles sorted by number of sources associating them with FLRT3)

Utopia: connect your pdf to the dynamic world of online information

1. Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins. (PubMed id 10644439)^{1, 2, 3} Lacy S.E.... Kunkel L.M. (1999)
2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)^{1, 2} Otsuki T....Isogai T. (2005)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
7. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)^{1, 2} Nagase T.... Ohara O. (2000)
8. FLRT proteins are endogenous latrophilin ligands and r egulate excitatory synapse development. (PubMed id 22405201)¹ O'Sullivan M.L....Ghosh A. (2012)
9. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)² Varela I....Futreal P.A. (2011)
10. Lack of C20orf133 and FLRT3 mutations in 43 patients with Kabuki syndrome in Japan. (PubMed id 18593871)¹ Kuniba H....Niikawa N. (2008)

External Searches for FLRT3 gene

Genome Databases showing FLRT3 gene

Other Databases showing FLRT3 gene

Specialized Databases showing FLRT3 gene

Products
for FLRT3 gene