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FLRT3 Gene

protein-coding   GIFtS: 56
GCID: GC20M014251

Fibronectin Leucine Rich Transmembrane Protein 3

  See FLRT3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fibronectin Leucine Rich Transmembrane Protein 31 2
Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 32 3
HH212 5
Leucine-Rich Repeat Transmembrane Protein FLRT32
KIAA14693

External Ids:    HGNC: 37621   Entrez Gene: 237672   Ensembl: ENSG000001258487   OMIM: 6048085   UniProtKB: Q9NZU03   

Export aliases for FLRT3 gene to outside databases

Previous GC identifers: GC20M014292 GC20M014298 GC20M014299


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FLRT3 Gene:
This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRTs may function
in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans
found in the extracellular matrix. This gene is expressed in many tissues. Two alternatively spliced transcript
variants encoding the same protein have been described for this gene. (provided by RefSeq, Jul 2010)

GeneCards Summary for FLRT3 Gene:
FLRT3 (fibronectin leucine rich transmembrane protein 3) is a protein-coding gene. Diseases associated with FLRT3 include hypogonadotropic hypogonadism 21 with anosmia, and kabuki syndrome. GO annotations related to this gene include receptor signaling protein activity and protein binding, bridging. An important paralog of this gene is PODN.

UniProtKB/Swiss-Prot: FLRT3_HUMAN, Q9NZU0
Function: May have a function in cell adhesion and/or receptor signaling

Gene Wiki entry for FLRT3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011387.9  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FLRT3 gene promoter:
         SRY   LHX3b/Lhx3b   Olf-1   LHX3a/Lhx3a   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFLRT3 promoter sequence
   Search Chromatin IP Primers for FLRT3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FLRT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11   Ensembl cytogenetic band:  20p12.1   HGNC cytogenetic band: 20p11

FLRT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FLRT3 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M014251:  view genomic region     (about GC identifiers)

Start:
14,303,634 bp from pter      End:
14,318,313 bp from pter
Size:
14,680 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FLRT3_HUMAN, Q9NZU0 (See protein sequence)
Recommended Name: Leucine-rich repeat transmembrane protein FLRT3 precursor  
Size: 649 amino acids; 73004 Da
Sequence caution: Sequence=BAA95993.1; Type=Erroneous initiation; Sequence=BAB55282.1; Type=Erroneous initiation;
Sequence=BAB55303.1; Type=Erroneous initiation;
Secondary accessions: D3DW20 Q542Z9 Q96K39 Q96K42 Q96KB1 Q9P259

Explore the universe of human proteins at neXtProt for FLRT3: NX_Q9NZU0

Explore proteomics data for FLRT3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn226, Asn282, Asn296, Thr510, Thr511, Thr512
  • Modification sites at PhosphoSitePlus

  • See FLRT3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_037413.1  NP_938205.1  

    ENSEMBL proteins: 
     ENSP00000367292   ENSP00000339912  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing

    5 InterPro protein domains:
     IPR000483 Cys-rich_flank_reg_C
     IPR001611 Leu-rich_rpt
     IPR003961 Fibronectin_type3
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR000372 LRR-contain_N

    Graphical View of Domain Structure for InterPro Entry Q9NZU0

    ProtoNet protein and cluster: Q9NZU0

    2 Blocks protein domains:
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region


    UniProtKB/Swiss-Prot: FLRT3_HUMAN, Q9NZU0
    Similarity: Contains 1 fibronectin type-III domain
    Similarity: Contains 10 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain


    Find genes that share domains with FLRT3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FLRT3_HUMAN, Q9NZU0
    Function: May have a function in cell adhesion and/or receptor signaling

         Genatlas biochemistry entry for FLRT3:
    fibronectin,leucine rich transmembrane protein 3,extracellular membrane,expressed in
    kidney,brain,pancreas,skeletal muscle,lung,liver,placenta,heart,related to ECM small leucine-rich proteoglycans

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005057receptor signaling protein activity NAS10644439
    GO:0005515protein binding ----
    GO:0030674protein binding, bridging NAS10644439
         
    Find genes that share ontologies with FLRT3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for FLRT3:
     G0/1 arrest  Increased G1 DNA content 

         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Flrt3):
     cardiovascular system  embryogenesis  growth/size/body  mortality/aging  nervous system 
     other 

    Find genes that share phenotypes with FLRT3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Flrt3tm2Kln for FLRT3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FLRT3
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    miRNA
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    Block miRNA regulation of human, mouse, rat FLRT3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FLRT3 (see all 75):
    hsa-miR-124* hsa-miR-548j hsa-miR-193a-3p hsa-miR-300 hsa-miR-199a-3p hsa-miR-128 hsa-miR-219-5p hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidFLRT3 3' UTR sequence
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    Sino Biological Human cDNA Clone for FLRT3
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FLRT3_HUMAN, Q9NZU0: Membrane; Single-pass type I membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    peroxisome2
    cytoskeleton1
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix NAS10644439
    GO:0005887integral component of plasma membrane NAS10644439

    Find genes that share ontologies with FLRT3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FLRT3
    Interactions:

        Search GeneGlobe Interaction Network for FLRT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for FLRT3 (Q9NZU03 ENSP000003399124) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PHB2Q996233, ENSP000003823624I2D: score=1 STRING: ENSP00000382362
    FGFR1ENSP000003802804STRING: ENSP00000380280
    UNC5BENSP000003343294STRING: ENSP00000334329
    UNC5CENSP000004060224STRING: ENSP00000406022
    CAB39ENSP000002584184STRING: ENSP00000258418
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007411axon guidance IEA--
    GO:0008150biological_process ND--
    GO:0035556intracellular signal transduction NAS10644439

    Find genes that share ontologies with FLRT3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FLRT3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FLRT3 gene (2 alternative transcripts): 
    NM_013281.3  NM_198391.2  

    Unigene Cluster for FLRT3:

    Fibronectin leucine rich transmembrane protein 3
    Hs.41296  [show with all ESTs]
    Unigene Representative Sequence: AB040902
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378053 ENST00000341420(uc002wov.2 uc002wow.2) ENST00000462077

    miRNA
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    Block miRNA regulation of human, mouse, rat FLRT3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FLRT3 (see all 75):
    hsa-miR-124* hsa-miR-548j hsa-miR-193a-3p hsa-miR-300 hsa-miR-199a-3p hsa-miR-128 hsa-miR-219-5p hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidFLRT3 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): FLRT3 (NM_198391)
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      QuantiFast Probe-based Assays in human, mouse, rat FLRT3

    Additional mRNA sequence: 

    AB040902.1 AF169677.1 AK027297.1 AK027670.1 AK027694.1 AK074883.1 AK074909.1 AY358319.1 
    BC020870.1 

    7 DOTS entries:

    DT.212647  DT.91715842  DT.120824321  DT.120824162  DT.95347696  DT.97794693  DT.439689 

    Selected AceView cDNA sequences (see all 86):

    AA227236 NM_198391 AW627443 AL528430 CR596010 AA455906 BI438867 BC020870 
    NM_013281 AB040902 AI383047 BM996218 BI335837 AA456372 AK074883 AL529481 
    AY358319 AK027694 AI383048 AK074909 CD644132 AA722941 AI912848 AK027670 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FLRT3    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b
    SP1:                          -               
    SP2:                    -     -               
    SP3:                                          


    ECgene alternative splicing isoforms for FLRT3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FLRT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTTTCTA
    FLRT3 Expression
    About this image


    FLRT3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     NULL (Uncategorized)    fully expand to see all 3 entries
             Mesoderm-like cells
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Mesencephalic Ventricular Zone
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Visceral White Adipose
             HyStem+BMP4-induced 7SMOO32 cells
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Neural Crest (Gastrulation Derivatives)
             PureStem MEL2, NCr-fac Progenitor
    FLRT3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FLRT3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.41296

    UniProtKB/Swiss-Prot: FLRT3_HUMAN, Q9NZU0
    Tissue specificity: Expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FLRT3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Flrt31 , 5 fibronectin leucine rich transmembrane protein 31, 5 90.19(n)1
    96.3(a)1
      2 (69.20 cM)5
    714361  NM_001172160.11  NP_001165631.11 
     1406509145 
    chicken
    (Gallus gallus)
    Aves FLRT31 fibronectin leucine rich transmembrane protein 3 79.29(n)
    87.79(a)
      428552  XM_004940161.1  XP_004940218.1 
    lizard
    (Anolis carolinensis)
    Reptilia FLRT36
    fibronectin leucine rich transmembrane protein 3
    83(a)
    1 ↔ 1
    1(132985748-132987739)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480129872   -- 87.64(n)    48012987 
    zebrafish
    (Danio rerio)
    Actinopterygii flrt31 fibronectin leucine rich transmembrane 3 68.57(n)
    73.46(a)
      558864  NM_001256646.1  NP_001243575.1 


    ENSEMBL Gene Tree for FLRT3 (if available)
    TreeFam Gene Tree for FLRT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FLRT3 gene
    PODN2  FLRT12  PODNL12  FMOD2  KERA2  PRELP2  OMD2  ASPN2  
    BGN2  DCN2  FLRT22  ECM22  LOC1005090912  LUM2  
    2 SIMAP similar genes for FLRT3 using alignment to 1 protein entry:     FLRT3_HUMAN:
    FLRT1    FLRT2

    Find genes that share paralogs with FLRT3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    8 SNPs for FLRT3    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0699534
    Hypogonadotropic hypogonadism 21 with or without anosmia (HH21)4--see VAR_0699532 K R mis40--------
    VAR_0699514
    Hypogonadotropic hypogonadism 21 with or without anosmia (HH21)4--see VAR_0699512 E G mis40--------
    VAR_0699504
    Hypogonadotropic hypogonadism 21 with or without anosmia (HH21)4--see VAR_0699502 Q K mis40--------
    VAR_0699524
    Hypogonadotropic hypogonadism 21 with or without anosmia (HH21)4--see VAR_0699522 S I mis40--------
    rs352537311,2,4
    ----see VAR_0509982 mis40--------
    rs60793911,2,4
    ----see VAR_0171522 mis40--------
    rs81206931,2,4
    ----see VAR_0509972 mis40--------
    VAR_0647144
    ----see VAR_0647142 I V mis40--------

    HapMap Linkage Disequilibrium report for FLRT3 (14303634 - 14318313 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FLRT3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv470540CNV Gain18288195
    nsv458872CNV Gain19166990

    Human Gene Mutation Database (HGMD): FLRT3
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing FLRT3
    DNA2.0 Custom Variant and Variant Library Synthesis for FLRT3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604808   
    OMIM disorders: 615271  
    UniProtKB/Swiss-Prot: FLRT3_HUMAN, Q9NZU0
  • Hypogonadotropic hypogonadism 21 with or without anosmia (HH21) [MIM:615271]: A disorder characterized by
    absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating
    gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it
    is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss.
    Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is
    due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of
    gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic
    hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been
    termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). Note=The disease is caused by mutations
    affecting distinct genetic loci, including the gene represented in this entry. Some patients carrying mutations
    in FLRT3 also have a mutation in another HH-associated gene including FGFR1, HS6ST1 and FGF17 (PubMed:23643382)

  • 3 diseases for FLRT3:    
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    hypogonadotropic hypogonadism 21 with anosmia    kabuki syndrome    hypogonadotropic hypogonadism 8 with or without anosmia


    Find genes that share disorders with FLRT3           About GenesLikeMe

    Genetic Association Database (GAD): FLRT3
    Human Genome Epidemiology (HuGE) Navigator: FLRT3 (1 document)

    Export disorders for FLRT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FLRT3 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with FLRT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins. (PubMed id 10644439)1, 2, 3 Lacy S.E.... Kunkel L.M. (Genomics 1999)
    2. Lack of C20orf133 and FLRT3 mutations in 43 patients with Kabuki syndrome in Japan. (PubMed id 18593871)1, 4 Kuniba H....Niikawa N. (J. Med. Genet. 2008)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    8. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    9. Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. (PubMed id 23643382)2 Miraoui H....Pitteloud N. (Am. J. Hum. Genet. 2013)
    10. FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development. (PubMed id 22405201)1 O'Sullivan M.L....Ghosh A. (Neuron 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23767 HGNC: 3762 AceView: FLRT3 Ensembl:ENSG00000125848 euGenes: HUgn23767
    ECgene: FLRT3 H-InvDB: FLRT3

    (According to HUGE)
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    HUGE: KIAA1469

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FLRT3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FLRT3 gene:
    Search GeneIP for patents involving FLRT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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