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Aliases for FLRT3 Gene

Aliases for FLRT3 Gene

  • Fibronectin Leucine Rich Transmembrane Protein 3 2 3
  • Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 3 3 4
  • HH21 3 6
  • Leucine-Rich Repeat Transmembrane Protein FLRT3 3
  • KIAA1469 4

External Ids for FLRT3 Gene

Previous GeneCards Identifiers for FLRT3 Gene

  • GC20M014292
  • GC20M014298
  • GC20M014299
  • GC20M014251

Summaries for FLRT3 Gene

Entrez Gene Summary for FLRT3 Gene

  • This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRTs may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. This gene is expressed in many tissues. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for FLRT3 Gene

FLRT3 (Fibronectin Leucine Rich Transmembrane Protein 3) is a Protein Coding gene. Diseases associated with FLRT3 include hypogonadotropic hypogonadism 21 with anosmia and kallmann syndrome. GO annotations related to this gene include protein binding, bridging and receptor signaling protein activity. An important paralog of this gene is ECM2.

UniProtKB/Swiss-Prot for FLRT3 Gene

  • May have a function in cell adhesion and/or receptor signaling

Gene Wiki entry for FLRT3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLRT3 Gene

Genomics for FLRT3 Gene

Regulatory Elements for FLRT3 Gene

Genomic Location for FLRT3 Gene

14,322,988 bp from pter
14,337,667 bp from pter
14,680 bases
Minus strand

Genomic View for FLRT3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FLRT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FLRT3 Gene

Proteins for FLRT3 Gene

  • Protein details for FLRT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat transmembrane protein FLRT3
    Protein Accession:
    Secondary Accessions:
    • D3DW20
    • Q542Z9
    • Q96K39
    • Q96K42
    • Q96KB1
    • Q9P259

    Protein attributes for FLRT3 Gene

    649 amino acids
    Molecular mass:
    73004 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA95993.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55282.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55303.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FLRT3 Gene

Proteomics data for FLRT3 Gene at MOPED

Post-translational modifications for FLRT3 Gene

  • Glycosylation at Asn226, Asn282, Asn296, Thr510, Thr511, and Thr512
  • Modification sites at PhosphoSitePlus

Other Protein References for FLRT3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FLRT3 Gene

Domains for FLRT3 Gene

Gene Families for FLRT3 Gene

  • FN3 :Fibronectin type III domain containing

Graphical View of Domain Structure for InterPro Entry



  • Q9NZU0
  • Contains 1 fibronectin type-III domain.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
  • Contains 10 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FLRT3: view

Function for FLRT3 Gene

Molecular function for FLRT3 Gene

GENATLAS Biochemistry:
fibronectin,leucine rich transmembrane protein 3,extracellular membrane,expressed in kidney,brain,pancreas,skeletal muscle,lung,liver,placenta,heart,related to ECM small leucine-rich proteoglycans
UniProtKB/Swiss-Prot Function:
May have a function in cell adhesion and/or receptor signaling

Gene Ontology (GO) - Molecular Function for FLRT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 receptor signaling protein activity NAS 10644439
GO:0005515 protein binding --
GO:0030674 protein binding, bridging NAS 10644439
GO:0045499 chemorepellent activity IEA --
genes like me logo Genes that share ontologies with FLRT3: view
genes like me logo Genes that share phenotypes with FLRT3: view

Animal Models for FLRT3 Gene

MGI Knock Outs for FLRT3:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FLRT3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for FLRT3 Gene

Localization for FLRT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLRT3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for FLRT3 Gene COMPARTMENTS Subcellular localization image for FLRT3 gene
Compartment Confidence
extracellular 5
plasma membrane 5
peroxisome 2
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for FLRT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix NAS 10644439
GO:0005615 extracellular space IEA --
GO:0005887 integral component of plasma membrane NAS 10644439
genes like me logo Genes that share ontologies with FLRT3: view

Pathways for FLRT3 Gene

SuperPathways for FLRT3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FLRT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007411 axon guidance IEA --
GO:0008150 biological_process ND --
GO:0035556 intracellular signal transduction NAS 10644439
GO:0050919 negative chemotaxis IEA --
genes like me logo Genes that share ontologies with FLRT3: view

No data available for Pathways by source for FLRT3 Gene

Transcripts for FLRT3 Gene

Unigene Clusters for FLRT3 Gene

Fibronectin leucine rich transmembrane protein 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FLRT3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FLRT3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2: - -

Relevant External Links for FLRT3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FLRT3 Gene

mRNA expression in normal human tissues for FLRT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FLRT3 Gene

This gene is overexpressed in Lung (5.1) and Kidney - Cortex (4.3).

Protein differential expression in normal tissues for FLRT3 Gene

This gene is overexpressed in Lung (29.2), Pancreas (13.8), Bone (10.3), and Cerebral cortex (9.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FLRT3 Gene

SOURCE GeneReport for Unigene cluster for FLRT3 Gene Hs.41296

mRNA Expression by UniProt/SwissProt for FLRT3 Gene

Tissue specificity: Expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart.
genes like me logo Genes that share expressions with FLRT3: view

In Situ Assay Products

No data available for Expression partners for FLRT3 Gene

Orthologs for FLRT3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FLRT3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FLRT3 35
  • 93.12 (n)
  • 97.69 (a)
FLRT3 36
  • 98 (a)
(Canis familiaris)
Mammalia FLRT3 35
  • 93.58 (n)
  • 97.53 (a)
FLRT3 36
  • 98 (a)
(Mus musculus)
Mammalia Flrt3 35
  • 90.19 (n)
  • 96.3 (a)
Flrt3 16
Flrt3 36
  • 96 (a)
(Pan troglodytes)
Mammalia FLRT3 35
  • 99.79 (n)
  • 100 (a)
FLRT3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Flrt3 35
  • 90.19 (n)
  • 96.3 (a)
(Monodelphis domestica)
Mammalia FLRT3 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia FLRT3 36
  • 90 (a)
(Gallus gallus)
Aves FLRT3 35
  • 79.29 (n)
  • 87.79 (a)
FLRT3 36
  • 88 (a)
(Anolis carolinensis)
Reptilia FLRT3 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia flrt3 35
  • 74.33 (n)
  • 80.4 (a)
(Danio rerio)
Actinopterygii flrt3 35
  • 68.57 (n)
  • 73.46 (a)
flrt3 36
  • 73 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
-- 36
  • 33 (a)
Species with no ortholog for FLRT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FLRT3 Gene

Gene Tree for FLRT3 (if available)
Gene Tree for FLRT3 (if available)

Paralogs for FLRT3 Gene

Paralogs for FLRT3 Gene

Selected SIMAP similar genes for FLRT3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FLRT3: view

Variants for FLRT3 Gene

Sequence variations from dbSNP and Humsavar for FLRT3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
VAR_017152 -
VAR_050997 -
VAR_050998 -
VAR_064714 -
VAR_069950 Hypogonadotropic hypogonadism 21 with or without anosmia (HH21)

Structural Variations from Database of Genomic Variants (DGV) for FLRT3 Gene

Variant ID Type Subtype PubMed ID
nsv458872 CNV Gain 19166990
nsv470540 CNV Gain 18288195

Relevant External Links for FLRT3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLRT3 Gene

Disorders for FLRT3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for FLRT3 Gene in MalaCards »

(2) Diseases for FLRT3 Gene including...

(1) OMIM Diseases for FLRT3 Gene (604808)


  • Hypogonadotropic hypogonadism 21 with or without anosmia (HH21) [MIM:615271]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). {ECO:0000269 PubMed:23643382}. Note=The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Some patients carrying mutations in FLRT3 also have a mutation in another HH-associated gene including FGFR1, HS6ST1 and FGF17 (PubMed:23643382). {ECO:0000269 PubMed:23643382}.

Relevant External Links for FLRT3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with FLRT3: view

No data available for University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for FLRT3 Gene

Publications for FLRT3 Gene

  1. Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins. (PMID: 10644439) Lacy S.E. … Kunkel L.M. (Genomics 1999) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for FLRT3 Gene

Sources for FLRT3 Gene

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