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Aliases for FLRT3 Gene

Aliases for FLRT3 Gene

  • Fibronectin Leucine Rich Transmembrane Protein 3 2 3 5
  • Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 3 3 4
  • KIAA1469 4
  • HH21 3

External Ids for FLRT3 Gene

Previous GeneCards Identifiers for FLRT3 Gene

  • GC20M014292
  • GC20M014298
  • GC20M014299
  • GC20M014251

Summaries for FLRT3 Gene

Entrez Gene Summary for FLRT3 Gene

  • This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRTs may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. This gene is expressed in many tissues. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for FLRT3 Gene

FLRT3 (Fibronectin Leucine Rich Transmembrane Protein 3) is a Protein Coding gene. Diseases associated with FLRT3 include hypogonadotropic hypogonadism 21 with anosmia and kallmann syndrome. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include protein binding, bridging and chemorepellent activity. An important paralog of this gene is ECM2.

UniProtKB/Swiss-Prot for FLRT3 Gene

  • Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina (By similarity). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed:26235030). Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members (By similarity). Promotes neurite outgrowth (in vitro) (PubMed:14706654). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development (By similarity).

Gene Wiki entry for FLRT3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLRT3 Gene

Genomics for FLRT3 Gene

Regulatory Elements for FLRT3 Gene

Genomic Location for FLRT3 Gene

Chromosome:
20
Start:
14,322,988 bp from pter
End:
14,337,667 bp from pter
Size:
14,680 bases
Orientation:
Minus strand

Genomic View for FLRT3 Gene

Genes around FLRT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FLRT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FLRT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FLRT3 Gene

Proteins for FLRT3 Gene

  • Protein details for FLRT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZU0-FLRT3_HUMAN
    Recommended name:
    Leucine-rich repeat transmembrane protein FLRT3
    Protein Accession:
    Q9NZU0
    Secondary Accessions:
    • D3DW20
    • Q542Z9
    • Q96K39
    • Q96K42
    • Q96KB1
    • Q9P259

    Protein attributes for FLRT3 Gene

    Size:
    649 amino acids
    Molecular mass:
    73004 Da
    Quaternary structure:
    • Monomer and homodimer. Self-associates (via leucine-rich repeats), giving rise to homooligomers (PubMed:26235030). Interacts with FGFR1. Interacts (via extracellular domain) with ADGRL1/LPHN1 and LPHN2 (via olfactomedin-like domain) (By similarity). Interacts (via extracellular domain) with ADGRL3 (via olfactomedin-like domain); the interaction is direct (PubMed:26235030). Interacts (via extracellular domain) with UNC5B and UNC5D (via extracellular domain); the interaction is direct (PubMed:26235030). Identified in complexes composed of FLRT3, ADGRL3 and UNC5B, respectively FLRT3, ADGRL3 and UNC5D (PubMed:26235030). May also interact (via extracellular domain) with UNC5A and UNC5C. Interacts (via cytoplasmic domain) with ROBO1 (By similarity).
    SequenceCaution:
    • Sequence=BAA95993.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55282.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55303.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FLRT3 Gene

neXtProt entry for FLRT3 Gene

Proteomics data for FLRT3 Gene at MOPED

Post-translational modifications for FLRT3 Gene

  • N-glycosylated.
  • Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. Cleavage is probably effected by a metalloprotease.
  • Glycosylation at Asn 226, Asn 282, Asn 296, Thr 510, and Thr 512
  • Modification sites at PhosphoSitePlus

Other Protein References for FLRT3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FLRT3 Gene

Domains & Families for FLRT3 Gene

Gene Families for FLRT3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NZU0

UniProtKB/Swiss-Prot:

FLRT3_HUMAN :
  • Contains 1 fibronectin type-III domain.
  • Contains 10 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 fibronectin type-III domain.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Similarity:
  • Contains 10 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FLRT3: view

Function for FLRT3 Gene

Molecular function for FLRT3 Gene

GENATLAS Biochemistry:
fibronectin,leucine rich transmembrane protein 3,extracellular membrane,expressed in kidney,brain,pancreas,skeletal muscle,lung,liver,placenta,heart,related to ECM small leucine-rich proteoglycans
UniProtKB/Swiss-Prot Function:
Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina (By similarity). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed:26235030). Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members (By similarity). Promotes neurite outgrowth (in vitro) (PubMed:14706654). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development (By similarity).

Gene Ontology (GO) - Molecular Function for FLRT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 26235030
genes like me logo Genes that share ontologies with FLRT3: view
genes like me logo Genes that share phenotypes with FLRT3: view

Human Phenotype Ontology for FLRT3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FLRT3 Gene

MGI Knock Outs for FLRT3:

Animal Model Products

miRNA for FLRT3 Gene

miRTarBase miRNAs that target FLRT3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FLRT3 Gene

Localization for FLRT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLRT3 Gene

Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane. Cell junction, focal adhesion. Secreted. Cell projection, axon. Note=Detected on dendritic punctae that colocalize in part with glutamaergic synapses, but not with GABAergic synapses. Detected on axons and at axon termini. Detected at neuronal growth cones. Proteolytic cleavage in the juxtamembrane region gives rise to a shedded ectodomain. {ECO:0000250 UniProtKB:B1H234, ECO:0000250 UniProtKB:Q8BGT1}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FLRT3 Gene COMPARTMENTS Subcellular localization image for FLRT3 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for FLRT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction IEA --
genes like me logo Genes that share ontologies with FLRT3: view

Pathways & Interactions for FLRT3 Gene

genes like me logo Genes that share pathways with FLRT3: view

Pathways by source for FLRT3 Gene

Gene Ontology (GO) - Biological Process for FLRT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007416 synapse assembly ISS --
GO:0007507 heart development ISS --
GO:0035556 intracellular signal transduction NAS --
GO:0050919 negative chemotaxis IEA --
GO:0098609 cell-cell adhesion IDA 26235030
genes like me logo Genes that share ontologies with FLRT3: view

No data available for SIGNOR curated interactions for FLRT3 Gene

Drugs & Compounds for FLRT3 Gene

No Compound Related Data Available

Transcripts for FLRT3 Gene

Unigene Clusters for FLRT3 Gene

Fibronectin leucine rich transmembrane protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FLRT3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2: - -
SP3:

Relevant External Links for FLRT3 Gene

GeneLoc Exon Structure for
FLRT3
ECgene alternative splicing isoforms for
FLRT3

Expression for FLRT3 Gene

mRNA expression in normal human tissues for FLRT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FLRT3 Gene

This gene is overexpressed in Lung (x5.1) and Kidney - Cortex (x4.3).

Protein differential expression in normal tissues from HIPED for FLRT3 Gene

This gene is overexpressed in Lung (29.2), Pancreas (13.8), Bone (10.3), and Cerebral cortex (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FLRT3 Gene



SOURCE GeneReport for Unigene cluster for FLRT3 Gene Hs.41296

mRNA Expression by UniProt/SwissProt for FLRT3 Gene

Q9NZU0-FLRT3_HUMAN
Tissue specificity: Expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart.
genes like me logo Genes that share expression patterns with FLRT3: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for FLRT3 Gene

Orthologs for FLRT3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FLRT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FLRT3 35
  • 99.79 (n)
  • 100 (a)
FLRT3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FLRT3 36
  • 98 (a)
OneToOne
FLRT3 35
  • 93.12 (n)
  • 97.69 (a)
dog
(Canis familiaris)
Mammalia FLRT3 35
  • 93.58 (n)
  • 97.53 (a)
FLRT3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Flrt3 16
Flrt3 35
  • 90.19 (n)
  • 96.3 (a)
Flrt3 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FLRT3 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FLRT3 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Flrt3 35
  • 90.19 (n)
  • 96.3 (a)
chicken
(Gallus gallus)
Aves FLRT3 35
  • 79.29 (n)
  • 87.79 (a)
FLRT3 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FLRT3 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia flrt3 35
  • 74.33 (n)
  • 80.4 (a)
zebrafish
(Danio rerio)
Actinopterygii flrt3 36
  • 73 (a)
OneToOne
flrt3 35
  • 68.57 (n)
  • 73.46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
Species with no ortholog for FLRT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FLRT3 Gene

ENSEMBL:
Gene Tree for FLRT3 (if available)
TreeFam:
Gene Tree for FLRT3 (if available)

Paralogs for FLRT3 Gene

Paralogs for FLRT3 Gene

(2) SIMAP similar genes for FLRT3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FLRT3: view

Variants for FLRT3 Gene

Sequence variations from dbSNP and Humsavar for FLRT3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_069953 Hypogonadotropic hypogonadism 21 with or without anosmia (HH21)
VAR_069952 Hypogonadotropic hypogonadism 21 with or without anosmia (HH21)
VAR_069951 Hypogonadotropic hypogonadism 21 with or without anosmia (HH21)
VAR_069950 Hypogonadotropic hypogonadism 21 with or without anosmia (HH21)
VAR_064714 -

Structural Variations from Database of Genomic Variants (DGV) for FLRT3 Gene

Variant ID Type Subtype PubMed ID
nsv458872 CNV Gain 19166990
nsv470540 CNV Gain 18288195

Variation tolerance for FLRT3 Gene

Residual Variation Intolerance Score: 28.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.89; 87.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FLRT3 Gene

HapMap Linkage Disequilibrium report
FLRT3
Human Gene Mutation Database (HGMD)
FLRT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLRT3 Gene

Disorders for FLRT3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FLRT3 Gene - From: OMIM, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hypogonadotropic hypogonadism 21 with anosmia
  • hypogonadotropic hypogonadism 21 with or without anosmia
kallmann syndrome
  • familial hypogonadism with anosmia
- elite association - COSMIC cancer census association via MalaCards
Search FLRT3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FLRT3_HUMAN
  • Hypogonadotropic hypogonadism 21 with or without anosmia (HH21) [MIM:615271]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). {ECO:0000269 PubMed:23643382}. Note=The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Some patients carrying mutations in FLRT3 also have a mutation in another HH-associated gene including FGFR1, HS6ST1 and FGF17 (PubMed:23643382). {ECO:0000269 PubMed:23643382}.

Relevant External Links for FLRT3

Genetic Association Database (GAD)
FLRT3
Human Genome Epidemiology (HuGE) Navigator
FLRT3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FLRT3
genes like me logo Genes that share disorders with FLRT3: view

No data available for Genatlas for FLRT3 Gene

Publications for FLRT3 Gene

  1. Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins. (PMID: 10644439) Lacy S.E. … Kunkel L.M. (Genomics 1999) 2 3 4 67
  2. Structural basis of latrophilin-FLRT-UNC5 interaction in cell adhesion. (PMID: 26235030) Lu Y.C. … Arac D. (Structure 2015) 3
  3. FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development. (PMID: 22405201) O'Sullivan M.L. … Ghosh A. (Neuron 2012) 3
  4. Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE Consortium. (PMID: 20044523) Debette S. … Longstreth W.T. (Stroke 2010) 23
  5. A protocadherin-cadherin-FLRT3 complex controls cell adhesion and morphogenesis. (PMID: 20027292) Chen X. … Gumbiner B.M. (PLoS ONE 2009) 23

Products for FLRT3 Gene

Sources for FLRT3 Gene

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