Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FLRT3 Gene

protein-coding   GIFtS: 55
GCID: GC20M014251

Fibronectin Leucine Rich Transmembrane Protein 3

  Search for FLRT3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fibronectin Leucine Rich Transmembrane Protein 31 2
Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 32 3
HH212
Leucine-Rich Repeat Transmembrane Protein FLRT32
KIAA14693

External Ids:    HGNC: 37621   Entrez Gene: 237672   Ensembl: ENSG000001258487   OMIM: 6048085   UniProtKB: Q9NZU03   

Export aliases for FLRT3 gene to outside databases

Previous GC identifers: GC20M014292 GC20M014298 GC20M014299


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FLRT3 Gene:
This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRTs may function
in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans
found in the extracellular matrix. This gene is expressed in many tissues. Two alternatively spliced transcript
variants encoding the same protein have been described for this gene. (provided by RefSeq, Jul 2010)

GeneCards Summary for FLRT3 Gene: 
FLRT3 (fibronectin leucine rich transmembrane protein 3) is a protein-coding gene. GO annotations related to this gene include receptor signaling protein activity and protein binding, bridging. An important paralog of this gene is PODN.

UniProtKB/Swiss-Prot: FLRT3_HUMAN, Q9NZU0
Function: May have a function in cell adhesion and/or receptor signaling

Gene Wiki entry for FLRT3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011387.8  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FLRT3 gene promoter:
         SRY   LHX3b/Lhx3b   Olf-1   LHX3a/Lhx3a   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFLRT3 promoter sequence
   Search SABiosciences Chromatin IP Primers for FLRT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FLRT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11   Ensembl cytogenetic band:  20p12.1   HGNC cytogenetic band: 20p11

FLRT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FLRT3 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M014251:  view genomic region     (about GC identifiers)

Start:
14,303,634 bp from pter      End:
14,318,313 bp from pter
Size:
14,680 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FLRT3_HUMAN, Q9NZU0 (See protein sequence)
Recommended Name: Leucine-rich repeat transmembrane protein FLRT3 precursor  
Size: 649 amino acids; 73004 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Probable)
Sequence caution: Sequence=BAA95993.1; Type=Erroneous initiation; Sequence=BAB55282.1; Type=Erroneous initiation;
Sequence=BAB55303.1; Type=Erroneous initiation;
Secondary accessions: D3DW20 Q542Z9 Q96K39 Q96K42 Q96KB1 Q9P259

Explore the universe of human proteins at neXtProt for FLRT3: NX_Q9NZU0

Explore proteomics data for FLRT3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NZU0

  • FLRT3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FLRT3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_037413.1  NP_938205.1  

    ENSEMBL proteins: 
     ENSP00000367292   ENSP00000339912  

    Human Recombinant Protein Products for FLRT3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for FLRT3
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for FLRT3
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for FLRT3 
    OriGene Custom Protein Services for FLRT3
    GenScript Custom Purified and Recombinant Proteins Services for FLRT3
    Sino Biological Recombinant Protein for FLRT3
    Sino Biological Cell Lysate for FLRT3 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FLRT3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix NAS10644439
    GO:0005887integral to plasma membrane NAS10644439

    FLRT3 for ontologies           About GeneDecksing



    FLRT3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for FLRT3
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FLRT3
    GenScript Custom Superior Antibodies Services for FLRT3
    Abcam antibodies for FLRT3
    Cloud-Clone Corp. Antibodies for FLRT3 
    Search ThermoFisher Antibodies for FLRT3
    LSBio Antibodies in human, mouse, rat for FLRT3 

    Assay Products for FLRT3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FLRT3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FLRT3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FLRT3 
    Cloud-Clone Corp. CLIAs for FLRT3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FN3: Fibronectin type III domain containing

    5 InterPro protein domains:
     IPR000483 Cys-rich_flank_reg_C
     IPR001611 Leu-rich_rpt
     IPR003961 Fibronectin_type3
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR000372 LRR-contain_N

    Graphical View of Domain Structure for InterPro Entry Q9NZU0

    ProtoNet protein and cluster: Q9NZU0

    2 Blocks protein domains:
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region


    UniProtKB/Swiss-Prot: FLRT3_HUMAN, Q9NZU0
    Similarity: Contains 1 fibronectin type-III domain
    Similarity: Contains 10 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain


    FLRT3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FLRT3_HUMAN, Q9NZU0
    Function: May have a function in cell adhesion and/or receptor signaling

         Genatlas biochemistry entry for FLRT3:
    fibronectin,leucine rich transmembrane protein 3,extracellular membrane,expressed in
    kidney,brain,pancreas,skeletal muscle,lung,liver,placenta,heart,related to ECM small leucine-rich proteoglycans

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005057receptor signaling protein activity NAS10644439
    GO:0005515protein binding ----
    GO:0030674protein binding, bridging NAS10644439
         
    FLRT3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FLRT3:
     G0/1 arrest  Increased G1 DNA content 

         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Flrt3):
     cardiovascular system  embryogenesis  growth/size  mortality/aging  nervous system 
     other 

    FLRT3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Flrt3tm2Kln for FLRT3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FLRT3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FLRT3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FLRT3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FLRT3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FLRT3
    8/75 QIAGEN miScript miRNA Assays for microRNAs that regulate FLRT3 (see all 75):
    hsa-miR-124* hsa-miR-548j hsa-miR-193a-3p hsa-miR-300 hsa-miR-199a-3p hsa-miR-128 hsa-miR-219-5p hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidFLRT3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FLRT3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FLRT3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FLRT3
    Sirion Biotech Customized adenovirus for overexpression of FLRT3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for FLRT3 (see all 13)
    OriGene ORF clones in mouse, rat for FLRT3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FLRT3 (NM_198391)
    Sino Biological Human cDNA Clone for FLRT3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FLRT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLRT3
    Sirion Biotech Customized lentivirus for stable overexpression of FLRT3 
                         Customized lentivirus expression plasmids for stable overexpression of FLRT3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FLRT3
    Search LifeMap BioReagents cell lines for FLRT3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLRT3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FLRT3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for FLRT3 (Q9NZU03 ENSP000003399124) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PHB2Q996233, ENSP000003823624I2D: score=1 STRING: ENSP00000382362
    FGFR1ENSP000003802804STRING: ENSP00000380280
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0008150biological_process ND--

    FLRT3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FLRT3

    Search CenterWatch for drugs/clinical trials and news about FLRT3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FLRT3 gene (2 alternative transcripts): 
    NM_013281.3  NM_198391.2  

    Unigene Cluster for FLRT3:

    Fibronectin leucine rich transmembrane protein 3
    Hs.41296  [show with all ESTs]
    Unigene Representative Sequence: AB040902
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378053 ENST00000341420(uc002wov.2 uc002wow.2) ENST00000462077

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FLRT3
    8/75 QIAGEN miScript miRNA Assays for microRNAs that regulate FLRT3 (see all 75):
    hsa-miR-124* hsa-miR-548j hsa-miR-193a-3p hsa-miR-300 hsa-miR-199a-3p hsa-miR-128 hsa-miR-219-5p hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidFLRT3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FLRT3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FLRT3
    Clone
    Products:
         
    OriGene clones in human, mouse for FLRT3 (see all 13)
    OriGene ORF clones in mouse, rat for FLRT3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FLRT3 (NM_198391)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FLRT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLRT3
    Sirion Biotech Customized lentivirus for stable overexpression of FLRT3 
                         Customized lentivirus expression plasmids for stable overexpression of FLRT3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FLRT3
    OriGene qSTAR qPCR primer pairs in human, mouse for FLRT3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FLRT3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FLRT3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FLRT3

    Additional mRNA sequence: 

    AB040902.1 AF169677.1 AK027297.1 AK027670.1 AK027694.1 AK074883.1 AK074909.1 AY358319.1 
    BC020870.1 

    7 DOTS entries:

    DT.212647  DT.91715842  DT.120824321  DT.120824162  DT.95347696  DT.97794693  DT.439689 

    24/86 AceView cDNA sequences (see all 86):

    AL528430 AA227236 AK074883 AB040902 BI335837 BI438867 AY358319 AK027694 
    AL529481 NM_198391 AI383047 AW627443 NM_013281 AA456372 BM996218 BC020870 
    AA455906 CR596010 AA005065 BI755497 BM996482 AK027670 AL529480 W92235 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FLRT3    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b
    SP1:                          -               
    SP2:                    -     -               
    SP3:                                          


    ECgene alternative splicing isoforms for FLRT3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FLRT3 expression in normal human tissues (normalized intensities)      FLRT3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTTTCTA
    FLRT3 Expression
    About this image


    FLRT3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/24 selected tissues (see all 24) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Telencephalon
             brain/midbrain/lateral wall   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Endothelial Cells Blood Brain Barrier
             brain/midbrain/lateral wall   
     
     Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem Z11, Meso Progenitor
             Mesoderm-like cells ( Derivation of cardiomyocytes from pluripotent stem cells and...
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
             Human Trabecular Meshwork Cells (HTMC)   
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
             PureStem ES-335, Meso-latp Progenitor

    See FLRT3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FLRT3

    SOURCE GeneReport for Unigene cluster: Hs.41296

    UniProtKB/Swiss-Prot: FLRT3_HUMAN, Q9NZU0
    Tissue specificity: Expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart

        SABiosciences Custom PCR Arrays for FLRT3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FLRT3
    OriGene qSTAR qPCR primer pairs in human, mouse for FLRT3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FLRT3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FLRT3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FLRT3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLRT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FLRT3 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Flrt31 , 5 fibronectin leucine rich transmembrane protein 31, 5 90.19(n)1
    96.3(a)1
      2 (69.20 cM)5
    714361  NM_001172160.11  NP_001165631.11 
     1406509145 
    chicken
    (Gallus gallus)
    Aves FLRT31 fibronectin leucine rich transmembrane protein 3 79.29(n)
    87.79(a)
      428552  XM_426107.3  XP_426107.3 
    lizard
    (Anolis carolinensis)
    Reptilia FLRT36
    Uncharacterized protein
    83(a)
    1 ↔ 1
    1(132985748-132987739)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480129872   -- 87.64(n)    48012987 
    zebrafish
    (Danio rerio)
    Actinopterygii flrt31 fibronectin leucine rich transmembrane 3 68.57(n)
    73.46(a)
      558864  XM_682138.4  XP_687230.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tollo6
    Toll-66
    (see all 5)
    Toll-6
    (see all 5)
    6(a)
    5(a)
    (see all 5)
    possible ortholog
    possible ortholog
    (see all 5)
    3L(15228719-15235932)
    3L(15329792-15337417)
    worm
    (Caenorhabditis elegans)
    Secernentea tol-16
    lron-156
    (see all 7)
    Protein LRON-15
    (see all 7)
    7(a)
    7(a)
    (see all 7)
    possible ortholog
    possible ortholog
    (see all 7)
    I(443999-461607)
    II(6540217-6544892)


    ENSEMBL Gene Tree for FLRT3 (if available)
    TreeFam Gene Tree for FLRT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FLRT3 gene
    PODN2  FLRT12  PODNL12  FMOD2  KERA2  PRELP2  OMD2  ASPN2  
    BGN2  DCN2  FLRT22  ECM22  LUM2  
    2 SIMAP similar genes for FLRT3 using alignment to 1 protein entry:     FLRT3_HUMAN:
    FLRT1    FLRT2

    FLRT3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    4 SNPs in FLRT3 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0509984
    ----see VAR_0509982 E D mis40--------
    VAR_0171524
    ----see VAR_0171522 H Q mis40--------
    VAR_0509974
    ----see VAR_0509972 A T mis40--------
    VAR_0647144
    ----see VAR_0647142 I V mis40--------

    HapMap Linkage Disequilibrium report for FLRT3 (14303634 - 14318313 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FLRT3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv470540CNV Gain18288195
    nsv458872CNV Gain19166990


    Human Gene Mutation Database (HGMD): FLRT3
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing FLRT3
    DNA2.0 Custom Variant and Variant Library Synthesis for FLRT3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FLRT3 for disorders           About MalaCards
    OMIM gene information: 604808    OMIM disorders: --


    FLRT3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FLRT3
    Human Genome Epidemiology (HuGE) Navigator: FLRT3 (1 document)

    Export disorders for FLRT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FLRT3 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with FLRT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins. (PubMed id 10644439)1, 2, 3 Lacy S.E.... Kunkel L.M. (1999)
    2. Lack of C20orf133 and FLRT3 mutations in 43 patients with Kabuki syndrome in Japan. (PubMed id 18593871)1, 4 Kuniba H....Niikawa N. (2008)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    8. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
    9. FLRT proteins are endogenous latrophilin ligands and r egulate excitatory synapse development. (PubMed id 22405201)1 O'Sullivan M.L....Ghosh A. (2012)
    10. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23767 HGNC: 3762 AceView: FLRT3 Ensembl:ENSG00000125848 euGenes: HUgn23767
    ECgene: FLRT3 H-InvDB: FLRT3

    (According to HUGE)
    About This Section
    HUGE: KIAA1469

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FLRT3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FLRT3 gene:
    Search GeneIP for patents involving FLRT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for FLRT3 (FLRT3)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for FLRT3 (FLRT3)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FLRT3  
     OriGene qPCR primer pairs and template standards for FLRT3   Browse OriGene Protein Over-expression Lysates  
     OriGene MassSpec something-or-other for FLRT3   OriGene clones in human, mouse for FLRT3  
     OriGene qSTAR qPCR primer pairs in human, mouse for FLRT3   OriGene Purified Protein for FLRT3  
     OriGene ORF clones in mouse, rat for FLRT3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FLRT3   OriGene Custom Protein Services for FLRT3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FLRT3
     QIAGEN SeqTarget long-range PCR primers for resequencing FLRT3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FLRT3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FLRT3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FLRT3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FLRT3
     GenScript Custom Purified and Recombinant Proteins Services for FLRT3 GenScript cDNA clones with any tag delivered in your preferred vector for FLRT3
     GenScript Custom Assay Services for FLRT3 GenScript Custom Superior Antibodies Services for FLRT3
     GenScript Custom overexpressing Cell Line Services for FLRT3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FLRT3 promoter
     Search Chromatin IP Primers for FLRT3
     RT2 qPCR Primer Assay in human, mouse, rat FLRT3
     Search GNC Networks for FLRT3
     SABiosciences Custom PCR Arrays for FLRT3
     Search Tocris compounds for FLRT3
     Proteins and Antibodies for FLRT3
     Cell Lysates for FLRT3
     cDNA Clones for FLRT3
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Biologicals
     Novus Tissue Slides
     Antibodies for FLRT3
     See all of Abcam's Antibodies, Kits and Proteins for FLRT3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for FLRT3
     Antibodies for FLRT3
     ELISAs for FLRT3
     CLIAs for FLRT3
     Search LifeMap BioReagents cell lines for FLRT3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLRT3
     SwitchGear 3'UTR luciferase reporter plasmids for FLRT3
     SwitchGear Promoter luciferase reporter plasmids for FLRT3
     Search ThermoFisher Antibodies for FLRT3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLRT3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for FLRT3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FLRT3
    Customized:
     lentivirus for stable overexpression of FLRT3
     lentivirus expression plasmids for stable overexpression of FLRT3
     adenovirus for overexpression of FLRT3
     LSBio Antibodies in human, mouse, rat for FLRT3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FLRT3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4