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FLRT2 Gene

protein-coding   GIFtS: 57
GCID: GC14P085996

Fibronectin Leucine Rich Transmembrane Protein 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fibronectin Leucine Rich Transmembrane Protein 21 2
Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 22 3
Leucine-Rich Repeat Transmembrane Protein FLRT22
KIAA04053

External Ids:    HGNC: 37611   Entrez Gene: 237682   Ensembl: ENSG000001850707   OMIM: 6048075   UniProtKB: O431553   

Export aliases for FLRT2 gene to outside databases

Previous GC identifers: GC14P083593 GC14P079813 GC14P084077 GC14P085066 GC14P066165


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FLRT2 Gene:
This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRT family
members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small
leucine-rich proteoglycans found in the extracellular matrix. (provided by RefSeq, Jul 2008)

GeneCards Summary for FLRT2 Gene:
FLRT2 (fibronectin leucine rich transmembrane protein 2) is a protein-coding gene. GO annotations related to this gene include receptor signaling protein activity and protein binding, bridging. An important paralog of this gene is PODN.

UniProtKB/Swiss-Prot: FLRT2_HUMAN, O43155
Function: May have a function in cell adhesion and/or receptor signaling

Gene Wiki entry for FLRT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FLRT2 gene promoter:
         AhR   STAT1   Elk-1   FOXD3   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   Egr-4   Arnt   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): FLRT2 promoter sequence
   Search Chromatin IP Primers for FLRT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FLRT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24-q32   Ensembl cytogenetic band:  14q31.3   HGNC cytogenetic band: 14q24-q32

FLRT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FLRT2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P085996:  view genomic region     (about GC identifiers)

Start:
85,996,488 bp from pter      End:
86,095,034 bp from pter
Size:
98,547 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FLRT2_HUMAN, O43155 (See protein sequence)
Recommended Name: Leucine-rich repeat transmembrane protein FLRT2 precursor  
Size: 660 amino acids; 74049 Da
Sequence caution: Sequence=BAA23701.2; Type=Erroneous initiation;
Secondary accessions: A0AV84 B7ZLP3

Explore the universe of human proteins at neXtProt for FLRT2: NX_O43155

Explore proteomics data for FLRT2 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn202, Asn298, Asn433, Asn521
  • Modification sites at PhosphoSitePlus

  • See FLRT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037363.1  
    ENSEMBL proteins: 
     ENSP00000332879   ENSP00000451050  

    FLRT2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing

    5 InterPro protein domains:
     IPR000483 Cys-rich_flank_reg_C
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR000372 LRR-contain_N

    Graphical View of Domain Structure for InterPro Entry O43155

    ProtoNet protein and cluster: O43155

    2 Blocks protein domains:
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region


    UniProtKB/Swiss-Prot: FLRT2_HUMAN, O43155
    Similarity: Contains 1 fibronectin type-III domain
    Similarity: Contains 10 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain


    Find genes that share domains with FLRT2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FLRT2_HUMAN, O43155
    Function: May have a function in cell adhesion and/or receptor signaling

         Genatlas biochemistry entry for FLRT2:
    fibronectin,leucine rich transmembrane protein 2,extracellular matrix protein,expressed in pancreas,skeletal
    muscle,brain,heart

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005057receptor signaling protein activity NAS10644439
    GO:0005515protein binding ----
    GO:0030674protein binding, bridging NAS10644439
         
    Find genes that share ontologies with FLRT2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FLRT2:
     Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Flrt2):
     cardiovascular system  cellular  embryogenesis  homeostasis/metabolism  mortality/aging 
     nervous system 

    Find genes that share phenotypes with FLRT2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FLRT2: Flrt2tm1Rob Flrt2tm1.1Kln Flrt2tm1Lex

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FLRT2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FLRT2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FLRT2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FLRT2

    miRNA
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    Block miRNA regulation of human, mouse, rat FLRT2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FLRT2 (see all 84):
    hsa-miR-548j hsa-miR-140-5p hsa-miR-607 hsa-miR-4272 hsa-miR-605 hsa-miR-3074-3p hsa-miR-877* hsa-miR-3613-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat FLRT2

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    Sino Biological Human cDNA Clone for FLRT2
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLRT2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FLRT2_HUMAN, O43155: Membrane; Single-pass type I membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    peroxisome2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix NAS10644439
    GO:0005887integral component of plasma membrane NAS10644439

    Find genes that share ontologies with FLRT2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FLRT2
    Interactions:

        Search GeneGlobe Interaction Network for FLRT2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for FLRT2 (O431552, 3 ENSP000003328794) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FLRT1Q9NZU12, 3, ENSP000002468414MINT-1778563 I2D: score=1 STRING: ENSP00000246841
    GRB2P629933I2D: score=1 
    FLRT2O431552MINT-1778497
    CAB39ENSP000002584184STRING: ENSP00000258418
    CAB39LENSP000002616694STRING: ENSP00000261669
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    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0008150biological_process ND--
    GO:0035556intracellular signal transduction NAS10644439

    Find genes that share ontologies with FLRT2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FLRT2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FLRT2 gene: 
    NM_013231.4  

    Unigene Cluster for FLRT2:

    Fibronectin leucine rich transmembrane protein 2
    Hs.533710  [show with all ESTs]
    Unigene Representative Sequence: AF169676
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330753(uc001xvr.3 uc010atd.3) ENST00000556335 ENST00000557419
    ENST00000554746 ENST00000555398 ENST00000553627 ENST00000553650
    miRNA
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    Block miRNA regulation of human, mouse, rat FLRT2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FLRT2 (see all 84):
    hsa-miR-548j hsa-miR-140-5p hsa-miR-607 hsa-miR-4272 hsa-miR-605 hsa-miR-3074-3p hsa-miR-877* hsa-miR-3613-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FLRT2
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    GenScript: all cDNA clones in your preferred vector: FLRT2 (NM_013231)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLRT2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for FLRT2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FLRT2
      QuantiTect SYBR Green Assays in human, mouse, rat FLRT2
      QuantiFast Probe-based Assays in human, mouse, rat FLRT2

    Additional mRNA sequence: 

    AF169676.1 BC118629.1 

    2 DOTS entries:

    DT.316330  DT.95161958 

    Selected AceView cDNA sequences (see all 153):

    AL040721 AI149088 AA609504 BQ082154 N69056 AW022744 AI669836 NM_013231 
    AU118229 BF516353 CB216989 BP345594 AJ711452 BF370107 AA422104 BM126618 
    AI698999 BM712308 BX097136 BM545822 CA418947 BM832881 AA490103 AI076762 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FLRT2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c
    SP1:                          -           -                 -                                             
    SP2:                          -     -     -     -     -     -                                             
    SP3:                          -     -                                                                     
    SP4:                          -     -     -     -     -     -     -     -     -     -                     
    SP5:                                -     -     -     -     -     -     -     -     -                     


    ECgene alternative splicing isoforms for FLRT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FLRT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGATACTGCA
    FLRT2 Expression
    About this image


    FLRT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Neural Crest (Gastrulation Derivatives)
             PureStem SM30, NCr-fac & Meso-latp Progenitor
     
     NULL (Uncategorized)
             DKK1-induced cells
     
     Head Mesenchyme (Muscoskeletal System)
             Head Mesenchyme
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Heart (Cardiovascular System)
             Cardiomyocyte-like progenitor cells
    FLRT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FLRT2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.533710

    UniProtKB/Swiss-Prot: FLRT2_HUMAN, O43155
    Tissue specificity: Expressed in pancreas, skeletal muscle, brain, and heart

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLRT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FLRT2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Flrt21 , 5 fibronectin leucine rich transmembrane protein 21, 5 89.7(n)1
    97.27(a)1
      12 (46.44 cM)5
    3995581  NM_201518.41  NP_958926.11 
     956922265 
    chicken
    (Gallus gallus)
    Aves FLRT21 fibronectin leucine rich transmembrane protein 2 81.62(n)
    88.33(a)
      428901  XM_003641305.2  XP_003641353.1 
    lizard
    (Anolis carolinensis)
    Reptilia FLRT26
    fibronectin leucine rich transmembrane protein 2
    84(a)
    1 ↔ 1
    1(15393538-15395523)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia flrt22 fibronectin leucine rich transmembrane protein 2 80.83(n)    AJ605779.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570858312   -- 74.08(n)    57085831 


    ENSEMBL Gene Tree for FLRT2 (if available)
    TreeFam Gene Tree for FLRT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FLRT2 gene
    PODN2  FLRT12  PODNL12  FMOD2  KERA2  PRELP2  FLRT32  OMD2  
    ASPN2  BGN2  DCN2  ECM22  LOC1005090912  LUM2  
    2 SIMAP similar genes for FLRT2 using alignment to 1 protein entry:     FLRT2_HUMAN:
    FLRT3    FLRT1

    Find genes that share paralogs with FLRT2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FLRT2 (see all 1951)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs610184951,2
    C--66996764(+) TTTTT-/TTT   
      
    /TTTTT
    GGCCT
    1 -- int11NA 2
    rs1510357711,2
    --85998499(+) GCCACA/TGCCCC 1 -- int10--------
    rs1397976101,2
    C--85998672(+) ACCGGA/CCTTGT 1 -- int10--------
    rs1452890151,2
    --85998830(+) GGAAAG/TAGACT 1 -- int10--------
    rs801782781,2
    C--85998880(+) TAGCTG/TTCAAG 1 -- int10--------
    rs2001742771,2
    --85998913(+) GAATC-/TTTCTT 1 -- int10--------
    rs1849353431,2
    --85999463(+) TTAAAA/CCAGAA 1 -- int10--------
    rs680010521,2
    C,F--85999486(+) CTCCGG/AGAGAG 1 -- int16Minor allele frequency- A:0.21WA NA EA 364
    rs675582861,2
    C--85999565(+) AGGGAG/CAGGAG 1 -- int13Minor allele frequency- C:0.17NA EA 242
    rs1890507291,2
    --85999618(+) TAAACA/TTATCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for FLRT2 (85996488 - 86095034 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FLRT2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv85122CNV Insertion16902084

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FLRT2
    DNA2.0 Custom Variant and Variant Library Synthesis for FLRT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604807    OMIM disorders: --


    Find genes that share disorders with FLRT2           About GenesLikeMe

    Genetic Association Database (GAD): FLRT2
    Human Genome Epidemiology (HuGE) Navigator: FLRT2 (2 documents)

    Export disorders for FLRT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FLRT2 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with FLRT2)
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    1. Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins. (PubMed id 10644439)1, 2, 3 Lacy S.E.... Kunkel L.M. (Genomics 1999)
    2. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    3. Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development. (PubMed id 16872596)1, 3 Haines B.P....Rigby P.W. (Dev. Biol. 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    7. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2 Ishikawa K.... Ohara O. (DNA Res. 1997)
    8. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. (PubMed id 23583979)1 den Hoed M....Loos R.J. (Nat. Genet. 2013)
    9. Genome-wide association study identifies loci affecting blood copper, selenium and zinc. (PubMed id 23720494)1 Evans D.M....Whitfield J.B. (Hum. Mol. Genet. 2013)
    10. Genome-wide association study of age at menarche in African-American women. (PubMed id 23599027)1 Demerath E.W....Haiman C.A. (Hum. Mol. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23768 HGNC: 3761 AceView: FLRT2 Ensembl:ENSG00000185070 euGenes: HUgn23768
    ECgene: FLRT2 H-InvDB: FLRT2

    (According to HUGE)
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    HUGE: KIAA0405

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FLRT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FLRT2 gene:
    Search GeneIP for patents involving FLRT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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