Aliases for FLRT2 Gene
External Ids for FLRT2 Gene
Previous GeneCards Identifiers for FLRT2 Gene
This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRT family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. [provided by RefSeq, Jul 2008]
GeneCards Summary for FLRT2 Gene
FLRT2 (Fibronectin Leucine Rich Transmembrane Protein 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include protein binding, bridging and chemorepellent activity. An important paralog of this gene is ECM2.
UniProtKB/Swiss-Prot for FLRT2 Gene
Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis.