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Aliases for FLRT2 Gene

Aliases for FLRT2 Gene

  • Fibronectin Leucine Rich Transmembrane Protein 2 2 3
  • Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 2 4
  • KIAA0405 4

External Ids for FLRT2 Gene

Previous GeneCards Identifiers for FLRT2 Gene

  • GC14P083593
  • GC14P079813
  • GC14P084077
  • GC14P085066
  • GC14P085996
  • GC14P066165

Summaries for FLRT2 Gene

Entrez Gene Summary for FLRT2 Gene

  • This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRT family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. [provided by RefSeq, Jul 2008]

GeneCards Summary for FLRT2 Gene

FLRT2 (Fibronectin Leucine Rich Transmembrane Protein 2) is a Protein Coding gene. GO annotations related to this gene include protein binding, bridging and receptor signaling protein activity. An important paralog of this gene is ECM2.

UniProtKB/Swiss-Prot for FLRT2 Gene

  • May have a function in cell adhesion and/or receptor signaling

Gene Wiki entry for FLRT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLRT2 Gene

Genomics for FLRT2 Gene

Regulatory Elements for FLRT2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FLRT2 Gene

85,530,067 bp from pter
85,654,426 bp from pter
124,360 bases
Plus strand

Genomic View for FLRT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FLRT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FLRT2 Gene

Proteins for FLRT2 Gene

  • Protein details for FLRT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat transmembrane protein FLRT2
    Protein Accession:
    Secondary Accessions:
    • A0AV84
    • B7ZLP3

    Protein attributes for FLRT2 Gene

    660 amino acids
    Molecular mass:
    74049 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA23701.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FLRT2 Gene

Proteomics data for FLRT2 Gene at MOPED

Post-translational modifications for FLRT2 Gene

Other Protein References for FLRT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FLRT2 Gene

Domains for FLRT2 Gene

Gene Families for FLRT2 Gene

  • FN3 :Fibronectin type III domain containing

Graphical View of Domain Structure for InterPro Entry



  • O43155
  • Contains 1 fibronectin type-III domain.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
  • Contains 10 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FLRT2: view

Function for FLRT2 Gene

Molecular function for FLRT2 Gene

GENATLAS Biochemistry:
fibronectin,leucine rich transmembrane protein 2,extracellular matrix protein,expressed in pancreas,skeletal muscle,brain,heart
UniProtKB/Swiss-Prot Function:
May have a function in cell adhesion and/or receptor signaling

Gene Ontology (GO) - Molecular Function for FLRT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 receptor signaling protein activity NAS 10644439
GO:0005515 protein binding --
GO:0030674 protein binding, bridging NAS 10644439
GO:0045499 chemorepellent activity IEA --
genes like me logo Genes that share ontologies with FLRT2: view
genes like me logo Genes that share phenotypes with FLRT2: view

Animal Models for FLRT2 Gene

MGI Knock Outs for FLRT2:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FLRT2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for FLRT2 Gene

Localization for FLRT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLRT2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for FLRT2 Gene COMPARTMENTS Subcellular localization image for FLRT2 gene
Compartment Confidence
extracellular 5
plasma membrane 5
peroxisome 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FLRT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix NAS 10644439
GO:0005615 extracellular space IEA --
GO:0005887 integral component of plasma membrane NAS 10644439
GO:0005925 focal adhesion IDA 21423176
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FLRT2: view

Pathways for FLRT2 Gene

SuperPathways for FLRT2 Gene

No Data Available

Interacting Proteins for FLRT2 Gene

Gene Ontology (GO) - Biological Process for FLRT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007411 axon guidance IEA --
GO:0008150 biological_process ND --
GO:0035556 intracellular signal transduction NAS 10644439
GO:0050919 negative chemotaxis IEA --
genes like me logo Genes that share ontologies with FLRT2: view

No data available for Pathways by source for FLRT2 Gene

Transcripts for FLRT2 Gene

Unigene Clusters for FLRT2 Gene

Fibronectin leucine rich transmembrane protein 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FLRT2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FLRT2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c
SP1: - - -
SP2: - - - - - -
SP3: - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - - -

Relevant External Links for FLRT2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FLRT2 Gene

mRNA expression in normal human tissues for FLRT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FLRT2 Gene

This gene is overexpressed in Pancreas (4.8).

Protein differential expression in normal tissues for FLRT2 Gene

This gene is overexpressed in Platelet (42.3) and Ovary (8.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FLRT2 Gene

SOURCE GeneReport for Unigene cluster for FLRT2 Gene Hs.533710

mRNA Expression by UniProt/SwissProt for FLRT2 Gene

Tissue specificity: Expressed in pancreas, skeletal muscle, brain, and heart.
genes like me logo Genes that share expressions with FLRT2: view

In Situ Assay Products

No data available for Expression partners for FLRT2 Gene

Orthologs for FLRT2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FLRT2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FLRT2 35
  • 88.43 (n)
  • 94.7 (a)
FLRT2 36
  • 95 (a)
(Canis familiaris)
Mammalia FLRT2 35
  • 89.19 (n)
  • 96.52 (a)
FLRT2 36
  • 97 (a)
(Mus musculus)
Mammalia Flrt2 35
  • 89.7 (n)
  • 97.27 (a)
Flrt2 16
Flrt2 36
  • 97 (a)
(Pan troglodytes)
Mammalia FLRT2 35
  • 99.49 (n)
  • 99.55 (a)
FLRT2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Flrt2 35
  • 89.14 (n)
  • 96.36 (a)
(Monodelphis domestica)
Mammalia FLRT2 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia FLRT2 36
  • 91 (a)
(Gallus gallus)
Aves FLRT2 35
  • 81.62 (n)
  • 88.33 (a)
FLRT2 36
  • 88 (a)
(Anolis carolinensis)
Reptilia FLRT2 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia flrt2 35
flrt2 35
  • 73.13 (n)
  • 78.48 (a)
(Danio rerio)
Actinopterygii flrt2 35
  • 62.77 (n)
  • 64.95 (a)
flrt2 36
  • 61 (a)
flrt2 36
  • 62 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
-- 36
  • 35 (a)
Species with no ortholog for FLRT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FLRT2 Gene

Gene Tree for FLRT2 (if available)
Gene Tree for FLRT2 (if available)

Paralogs for FLRT2 Gene

Paralogs for FLRT2 Gene

Selected SIMAP similar genes for FLRT2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FLRT2: view

Variants for FLRT2 Gene

Sequence variations from dbSNP and Humsavar for FLRT2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs10309 -- 85,627,691(+) TCATA(A/G)GACTA utr-variant-3-prime
rs11131 -- 85,627,840(+) ATGTC(A/G)CACAC utr-variant-3-prime
rs761502 -- 85,535,036(+) AAGTG(C/T)AAGGC intron-variant
rs761504 -- 85,584,872(+) GCTTA(C/G)TTTTC intron-variant
rs910311 -- 85,584,516(+) ACATT(C/G)TGCAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FLRT2 Gene

Variant ID Type Subtype PubMed ID
nsv85122 CNV Insertion 16902084

Relevant External Links for FLRT2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLRT2 Gene

Disorders for FLRT2 Gene

Relevant External Links for FLRT2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for FLRT2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for FLRT2 Gene

Publications for FLRT2 Gene

  1. Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins. (PMID: 10644439) Lacy S.E. … Kunkel L.M. (Genomics 1999) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for FLRT2 Gene

Sources for FLRT2 Gene

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