FLRT2 Gene

Aliases
for FLRT2 gene

Previous GC identifers: GC14P083593 GC14P079813 GC14P084077 GC14P085066 GC14P066165

Summaries
for FLRT2 gene

Genomic Views
for FLRT2 gene

RefSeq DNA sequence:

NC_000014.8  NC_018925.1  NT_026437.12  

SwitchGear Promoter luciferase reporter plasmids (see all 3): FLRT2 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FLRT2

FLRT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P085996:  view genomic region     (about GC identifiers)

Proteins
for FLRT2 gene

Explore the universe of human proteins at neXtProt for FLRT2: NX_O43155

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for FLRT2
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: FLRT2 OriGene Protein Over-expression Lysate: FLRT2 OriGene Custom Protein Services for FLRT2
	GenScript Custom Purified and Recombinant Proteins Services for FLRT2
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for FLRT2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for FLRT2
	Browse OriGene Antibodies OriGene Custom Antibody Services for FLRT2
	GenScript Custom Superior Antibodies Services for FLRT2
	Search for Antibodies for FLRT2 at Abcam
	Uscn Antibodies for FLRT2
	Search ThermoFisher Antibodies for FLRT2

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for FLRT2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FLRT2

Protein Domains /
Families
for FLRT2 gene

ProtoNet protein and cluster: O43155

Function
for FLRT2 gene

miRNA Products:		OriGene 3'-UTR Clone: FLRT2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FLRT2
		8/84 QIAGEN miScript miRNA Assays for microRNAs that regulate FLRT2 (see all 84):
		hsa-miR-548j hsa-miR-140-5p hsa-miR-607 hsa-miR-4272 hsa-miR-605 hsa-miR-3074-3p hsa-miR-877* hsa-miR-3613-3p
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FLRT2 (see all 7) OriGene shRNA RFP: FLRT2 OriGene siRNA: FLRT2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FLRT2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for FLRT2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FLRT2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FLRT2 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FLRT2 (NM_013231)
		Sino Biological Human cDNA Clone for FLRT2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FLRT2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLRT2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FLRT2
		Search LifeMap BioReagents cell lines for FLRT2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLRT2

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 2 alleles) (MGI details for Flrt2)

Pathways & Interactions
for FLRT2 gene

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for FLRT2 gene

Transcripts
for FLRT2 gene

Expression
for FLRT2 gene

FLRT2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGATACTGCA

2 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	KidneyPodocyte LayerPodocytes			Kidney
	LungTracheaBasal Cells			Lung
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 6 LifeMap Cells
	Name			Category
	PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)			Blood, Endothelium
	PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)			Adipose, Bone, Cartilage
	PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)			Endothelium
	PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
	PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
	Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FLRT2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FLRT2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FLRT2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FLRT2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLRT2

Orthologs
for FLRT2 gene

Paralogs
for FLRT2 gene

Paralogs for FLRT2 gene

GP5²  FLRT1²  CPN2²  LRIG3²  LRRTM4²  CHAD²  FLRT3²  LRRC15²  

LRIG2²  LRRTM3²  IGFALS²  CHADL²  LRIG1²  LRRTM2²  VASN²  LRRTM1²  

2 SIMAP similar genes for FLRT2 using alignment to 1 protein entry:     FLRT2_HUMAN:

FLRT3    FLRT1

FLRT2 for paralogs           About GeneDecksing

Genomic Variants
for FLRT2 gene

10/1806 NCBI SNPs in FLRT2 are shown (see all 1806)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs80121391,2	C,F,A,H,	--	66164183(+)	ATGCTG/CCTTTC	1	--	int1		10		NS EA NA WA	1388
rs2021718341,2	C	--	66164408(+)	AGCATC/TCCCAC	1	--	nc-transcript-variant		0	--	--	--	--
rs2011598871,2	C	--	66164412(-)	GGCTGG/TGNNNN	1	--	nc-transcript-variant		0	--	--	--	--
rs733176151,2	C,	--	66164480(+)	TAGACT/CTGGGT	1	--	nc-transcript-variant		2		WA	120
rs744728351,2		--	66164635(+)	CCGGAA/GTGGAG	1	--	nc-transcript-variant		0	--	--	--	--
rs101491501,2	C,F,H,	--	66164795(+)	ATGACT/ACGCCT	1	--	nc-transcript-variant		5		NS EA WA	538
rs799593141,2	C,F,	--	66164943(+)	GATCAA/GAATGT	1	--	nc-transcript-variant		1		WA	118
rs763765541,2	C,F,	--	66165613(+)	TCTCGC/TCCCCG	1	--	nc-transcript-variant		1		WA	118
rs561056101,2	C,	--	66165953(+)	GCGGCA/CTCTCC	1	--	us2k1		4		WA CSA NA	241
rs740688131,2	C,	--	66166439(+)	TGGTAG/CATGCA	1	--	us2k1		1		WA	2

HapMap Linkage Disequilibrium report for FLRT2 (85996488 - 86095034 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for FLRT2: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FLRT2

DNA2.0 Custom Variant and Variant Library Synthesis for FLRT2

Disorders / Diseases
for FLRT2 gene

Publications
for FLRT2 gene

PubMed articles for FLRT2 gene, integrated from 9 sources (see all 12): (articles sorted by number of sources associating them with FLRT2)

Utopia: connect your pdf to the dynamic world of online information

1. Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins. (PubMed id 10644439)^{1, 2, 3} Lacy S.E.... Kunkel L.M. (1999)
2. Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development. (PubMed id 16872596)^{1, 3} Haines B.P....Rigby P.W. (2006)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
6. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)^{1, 2} Ishikawa K....Ohara O. (1997)
7. Genome-wide association study of lung function decline in adults with and without asthma. (PubMed id 22424883)¹ Imboden M....Probst-Hensch N.M. (2012)
8. Sequential use of transcriptional profiling, expressi on quantitative trait mapping, and gene association implicates MMP20 in human k idney aging. (PubMed id 19834535)¹ Wheeler H.E....Kim S.K. (2009)
9. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)² Chen R.... Zou H. (2009)
10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)

External Searches for FLRT2 gene

Genome Databases showing FLRT2 gene

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Specialized Databases showing FLRT2 gene

Products
for FLRT2 gene