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Aliases for FLRT2 Gene

Aliases for FLRT2 Gene

  • Fibronectin Leucine Rich Transmembrane Protein 2 2 3 5
  • Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 2 4
  • KIAA0405 4

External Ids for FLRT2 Gene

Previous GeneCards Identifiers for FLRT2 Gene

  • GC14P083593
  • GC14P079813
  • GC14P084077
  • GC14P085066
  • GC14P085996
  • GC14P066165

Summaries for FLRT2 Gene

Entrez Gene Summary for FLRT2 Gene

  • This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRT family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. [provided by RefSeq, Jul 2008]

GeneCards Summary for FLRT2 Gene

FLRT2 (Fibronectin Leucine Rich Transmembrane Protein 2) is a Protein Coding gene. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Signaling by GPCR. GO annotations related to this gene include protein binding, bridging and chemorepellent activity. An important paralog of this gene is ECM2.

UniProtKB/Swiss-Prot for FLRT2 Gene

  • Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis.

Gene Wiki entry for FLRT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLRT2 Gene

Genomics for FLRT2 Gene

Regulatory Elements for FLRT2 Gene

Enhancers for FLRT2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FLRT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FLRT2 Gene

Chromosome:
14
Start:
85,530,105 bp from pter
End:
85,654,426 bp from pter
Size:
124,322 bases
Orientation:
Plus strand

Genomic View for FLRT2 Gene

Genes around FLRT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FLRT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FLRT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FLRT2 Gene

Proteins for FLRT2 Gene

  • Protein details for FLRT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43155-FLRT2_HUMAN
    Recommended name:
    Leucine-rich repeat transmembrane protein FLRT2
    Protein Accession:
    O43155
    Secondary Accessions:
    • A0AV84
    • B7ZLP3

    Protein attributes for FLRT2 Gene

    Size:
    660 amino acids
    Molecular mass:
    74049 Da
    Quaternary structure:
    • Self-associates (via leucine-rich repeats), giving rise to homooligomers. Interacts with FGFR1. Interacts with FGFR2. Interacts (via extracellular domain) with ADGRL1/LPHN1. Interacts (via extracellular domain) with ADGRL3 (via olfactomedin-like domain). Interacts (via extracellular domain) with UNC5D (via the first Ig-like domain). Can also interact (via extracellular domain) with UNC5B, but with much lower affinity. Interacts (via extracellular domain) with FN1.
    SequenceCaution:
    • Sequence=BAA23701.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FLRT2 Gene

Proteomics data for FLRT2 Gene at MOPED

Post-translational modifications for FLRT2 Gene

  • N-glycosylated.
  • Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. Cleavage is probably effected by a metalloprotease.
  • Glycosylation at Asn 202, Asn 298, Asn 433, and Asn 521
  • Modification sites at PhosphoSitePlus

Other Protein References for FLRT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for FLRT2

No data available for DME Specific Peptides for FLRT2 Gene

Domains & Families for FLRT2 Gene

Gene Families for FLRT2 Gene

Graphical View of Domain Structure for InterPro Entry

O43155

UniProtKB/Swiss-Prot:

FLRT2_HUMAN :
  • Contains 1 fibronectin type-III domain.
  • Contains 10 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 fibronectin type-III domain.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Similarity:
  • Contains 10 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FLRT2: view

Function for FLRT2 Gene

Molecular function for FLRT2 Gene

GENATLAS Biochemistry:
fibronectin,leucine rich transmembrane protein 2,extracellular matrix protein,expressed in pancreas,skeletal muscle,brain,heart
UniProtKB/Swiss-Prot Function:
Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis.

Gene Ontology (GO) - Molecular Function for FLRT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with FLRT2: view
genes like me logo Genes that share phenotypes with FLRT2: view

Animal Models for FLRT2 Gene

MGI Knock Outs for FLRT2:

Animal Model Products

  • Taconic Biosciences Mouse Models for FLRT2

miRNA for FLRT2 Gene

miRTarBase miRNAs that target FLRT2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FLRT2 Gene

Localization for FLRT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLRT2 Gene

Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane. Cell junction, focal adhesion. Secreted, extracellular space, extracellular matrix. Microsome membrane. Secreted. Cell junction, synapse, synaptosome. Note=Proteolytic cleavage gives rise to a shedded ectodomain. {ECO:0000250 UniProtKB:Q8BLU0}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FLRT2 Gene COMPARTMENTS Subcellular localization image for FLRT2 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 3
peroxisome 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FLRT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005925 colocalizes_with focal adhesion ISS --
genes like me logo Genes that share ontologies with FLRT2: view

Pathways & Interactions for FLRT2 Gene

genes like me logo Genes that share pathways with FLRT2: view

Pathways by source for FLRT2 Gene

Interacting Proteins for FLRT2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000332879%0d%0a9606.ENSP00000246841%0d%0a9606.ENSP00000367208%0d%0a
Selected Interacting proteins: O43155-FLRT2_HUMAN ENSP00000332879 for FLRT2 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for FLRT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003007 heart morphogenesis ISS --
GO:1904030 negative regulation of cyclin-dependent protein kinase activity IBA --
genes like me logo Genes that share ontologies with FLRT2: view

No data available for SIGNOR curated interactions for FLRT2 Gene

Drugs & Compounds for FLRT2 Gene

No Compound Related Data Available

Transcripts for FLRT2 Gene

Unigene Clusters for FLRT2 Gene

Fibronectin leucine rich transmembrane protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FLRT2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c
SP1: - - -
SP2: - - - - - -
SP3: - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - - -
SP7:

Relevant External Links for FLRT2 Gene

GeneLoc Exon Structure for
FLRT2
ECgene alternative splicing isoforms for
FLRT2

Expression for FLRT2 Gene

mRNA expression in normal human tissues for FLRT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FLRT2 Gene

This gene is overexpressed in Pancreas (x4.8).

Protein differential expression in normal tissues from HIPED for FLRT2 Gene

This gene is overexpressed in Platelet (42.3) and Ovary (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FLRT2 Gene



SOURCE GeneReport for Unigene cluster for FLRT2 Gene Hs.533710

mRNA Expression by UniProt/SwissProt for FLRT2 Gene

O43155-FLRT2_HUMAN
Tissue specificity: Expressed in pancreas, skeletal muscle, brain, and heart.
genes like me logo Genes that share expression patterns with FLRT2: view

Primer Products

No data available for Protein tissue co-expression partners for FLRT2 Gene

Orthologs for FLRT2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FLRT2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FLRT2 35
  • 88.43 (n)
  • 94.7 (a)
FLRT2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FLRT2 35
  • 89.19 (n)
  • 96.52 (a)
FLRT2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Flrt2 35
  • 89.7 (n)
  • 97.27 (a)
Flrt2 16
Flrt2 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FLRT2 35
  • 99.49 (n)
  • 99.55 (a)
FLRT2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Flrt2 35
  • 89.14 (n)
  • 96.36 (a)
oppossum
(Monodelphis domestica)
Mammalia FLRT2 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FLRT2 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves FLRT2 35
  • 81.62 (n)
  • 88.33 (a)
FLRT2 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FLRT2 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia flrt2 35
flrt2 35
  • 73.13 (n)
  • 78.48 (a)
zebrafish
(Danio rerio)
Actinopterygii flrt2 35
  • 62.77 (n)
  • 64.95 (a)
flrt2 36
  • 61 (a)
OneToMany
flrt2 36
  • 62 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
Species with no ortholog for FLRT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FLRT2 Gene

ENSEMBL:
Gene Tree for FLRT2 (if available)
TreeFam:
Gene Tree for FLRT2 (if available)

Paralogs for FLRT2 Gene

Paralogs for FLRT2 Gene

(2) SIMAP similar genes for FLRT2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FLRT2: view

Variants for FLRT2 Gene

Sequence variations from dbSNP and Humsavar for FLRT2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs17646457 - 85,622,971(+) GCCCC(A/G)ATCCA reference, missense
rs10309 -- 85,627,691(+) TCATA(A/G)GACTA utr-variant-3-prime
rs11131 -- 85,627,840(+) ATGTC(A/G)CACAC utr-variant-3-prime
rs1473706 -- 85,581,843(+) ATTTT(A/G)TAGTG intron-variant
rs2638794 -- 85,605,166(-) AATAG(A/G)AAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FLRT2 Gene

Variant ID Type Subtype PubMed ID
nsv85122 CNV Insertion 16902084

Variation tolerance for FLRT2 Gene

Residual Variation Intolerance Score: 30.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.63; 78.25% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FLRT2 Gene

Disorders for FLRT2 Gene

Relevant External Links for FLRT2

Genetic Association Database (GAD)
FLRT2
Human Genome Epidemiology (HuGE) Navigator
FLRT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FLRT2

No disorders were found for FLRT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FLRT2 Gene

Publications for FLRT2 Gene

  1. Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins. (PMID: 10644439) Lacy S.E. … Kunkel L.M. (Genomics 1999) 2 3 4 67
  2. Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development. (PMID: 16872596) Haines B.P. … Rigby P.W. (Dev. Biol. 2006) 2 3
  3. Gene expression profiles in peripheral blood mononuclear cells of Asian obstructive sleep apnea patients. (PMID: 24732660) Lin S.W. … Chen N.H. (Biomed J 2014) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3

Products for FLRT2 Gene

Sources for FLRT2 Gene

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