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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FLRT2 Gene

protein-coding   GIFtS: 56
GCID: GC14P085996

Fibronectin Leucine Rich Transmembrane Protein 2

  Search for FLRT2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fibronectin Leucine Rich Transmembrane Protein 21 2
Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 22 3
Leucine-Rich Repeat Transmembrane Protein FLRT22
KIAA04053

External Ids:    HGNC: 37611   Entrez Gene: 237682   Ensembl: ENSG000001850707   OMIM: 6048075   UniProtKB: O431553   

Export aliases for FLRT2 gene to outside databases

Previous GC identifers: GC14P083593 GC14P079813 GC14P084077 GC14P085066 GC14P066165


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FLRT2 Gene:
This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRT family
members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small
leucine-rich proteoglycans found in the extracellular matrix. (provided by RefSeq, Jul 2008)

GeneCards Summary for FLRT2 Gene: 
FLRT2 (fibronectin leucine rich transmembrane protein 2) is a protein-coding gene. GO annotations related to this gene include receptor signaling protein activity and protein binding, bridging. An important paralog of this gene is PODN.

UniProtKB/Swiss-Prot: FLRT2_HUMAN, O43155
Function: May have a function in cell adhesion and/or receptor signaling

Gene Wiki entry for FLRT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FLRT2 gene promoter:
         AhR   STAT1   Elk-1   FOXD3   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   Egr-4   Arnt   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): FLRT2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FLRT2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FLRT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24-q32   Ensembl cytogenetic band:  14q31.3   HGNC cytogenetic band: 14q24-q32

FLRT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FLRT2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P085996:  view genomic region     (about GC identifiers)

Start:
85,996,488 bp from pter      End:
86,095,034 bp from pter
Size:
98,547 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FLRT2_HUMAN, O43155 (See protein sequence)
Recommended Name: Leucine-rich repeat transmembrane protein FLRT2 precursor  
Size: 660 amino acids; 74049 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Probable)
Sequence caution: Sequence=BAA23701.2; Type=Erroneous initiation;
Secondary accessions: A0AV84 B7ZLP3

Explore the universe of human proteins at neXtProt for FLRT2: NX_O43155

Explore proteomics data for FLRT2 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43155

  • FLRT2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FLRT2 Protein Expression
    REFSEQ proteins: NP_037363.1  
    ENSEMBL proteins: 
     ENSP00000332879   ENSP00000451050  

    Human Recombinant Protein Products for FLRT2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for FLRT2
    OriGene Protein Over-expression Lysate for FLRT2
    OriGene MassSpec for FLRT2 
    OriGene Custom Protein Services for FLRT2
    GenScript Custom Purified and Recombinant Proteins Services for FLRT2
    Novus Biologicals FLRT2 Protein
    Sino Biological Recombinant Protein for FLRT2
    Sino Biological Cell Lysate for FLRT2 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FLRT2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix NAS10644439
    GO:0005887integral to plasma membrane NAS10644439

    FLRT2 for ontologies           About GeneDecksing



    FLRT2 Antibody Products: 
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    Abcam antibodies for FLRT2
    Cloud-Clone Corp. Antibodies for FLRT2 
    ThermoFisher Antibodies for FLRT2
    Search LSBio for Antibodies for FLRT2 

    Assay Products for FLRT2: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FLRT2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FLRT2 
    Cloud-Clone Corp. CLIAs for FLRT2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FN3: Fibronectin type III domain containing

    5 InterPro protein domains:
     IPR000483 Cys-rich_flank_reg_C
     IPR003961 Fibronectin_type3
     IPR013783 Ig-like_fold
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR000372 LRR-contain_N

    Graphical View of Domain Structure for InterPro Entry O43155

    ProtoNet protein and cluster: O43155

    2 Blocks protein domains:
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region


    UniProtKB/Swiss-Prot: FLRT2_HUMAN, O43155
    Similarity: Contains 1 fibronectin type-III domain
    Similarity: Contains 10 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain


    FLRT2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FLRT2_HUMAN, O43155
    Function: May have a function in cell adhesion and/or receptor signaling

         Genatlas biochemistry entry for FLRT2:
    fibronectin,leucine rich transmembrane protein 2,extracellular matrix protein,expressed in pancreas,skeletal
    muscle,brain,heart

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005057receptor signaling protein activity NAS10644439
    GO:0005515protein binding ----
    GO:0030674protein binding, bridging NAS10644439
         
    FLRT2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FLRT2:
     Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Flrt2):
     cardiovascular system  cellular  embryogenesis  homeostasis/metabolism  mortality/aging 
     nervous system 

    FLRT2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FLRT2: Flrt2tm1Rob Flrt2tm1.1Kln Flrt2tm1Lex

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FLRT2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FLRT2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FLRT2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FLRT2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FLRT2
    8/84 QIAGEN miScript miRNA Assays for microRNAs that regulate FLRT2 (see all 84):
    hsa-miR-548j hsa-miR-140-5p hsa-miR-607 hsa-miR-4272 hsa-miR-605 hsa-miR-3074-3p hsa-miR-877* hsa-miR-3613-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FLRT2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FLRT2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for FLRT2
    Sirion Biotech Customized adenovirus for overexpression of FLRT2

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for FLRT2 (see all 7)
    OriGene ORF clones in mouse, rat for FLRT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FLRT2 (NM_013231)
    Sino Biological Human cDNA Clone for FLRT2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FLRT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLRT2
    Sirion Biotech Customized lentivirus for stable overexpression of FLRT2 
                         Customized lentivirus expression plasmids for stable overexpression of FLRT2 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for FLRT2
    Search LifeMap BioReagents cell lines for FLRT2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLRT2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FLRT2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    4 Interacting proteins for FLRT2 (O431552, 3 ENSP000003328794) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FLRT1Q9NZU12, 3, ENSP000002468414MINT-1778563 I2D: score=1 STRING: ENSP00000246841
    GRB2P629933I2D: score=1 
    FLRT2O431552MINT-1778497
    --Q70AK32MINT-1778457
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0008150biological_process ND--

    FLRT2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FLRT2

    Search CenterWatch for drugs/clinical trials and news about FLRT2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FLRT2 gene: 
    NM_013231.4  

    Unigene Clusters for FLRT2:

    Fibronectin leucine rich transmembrane protein 2
    Hs.533710  [show with all ESTs], Hs.744139  [show with all ESTs]
    Unigene Representative Sequences: AF169676, NM_013231
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330753(uc001xvr.3 uc010atd.3) ENST00000556335 ENST00000557419
    ENST00000554746 ENST00000555398 ENST00000553627 ENST00000553650
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FLRT2
    8/84 QIAGEN miScript miRNA Assays for microRNAs that regulate FLRT2 (see all 84):
    hsa-miR-548j hsa-miR-140-5p hsa-miR-607 hsa-miR-4272 hsa-miR-605 hsa-miR-3074-3p hsa-miR-877* hsa-miR-3613-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FLRT2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FLRT2
    Clone
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    OriGene clones in human, mouse for FLRT2 (see all 7)
    OriGene ORF clones in mouse, rat for FLRT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FLRT2 (NM_013231)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FLRT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLRT2
    Sirion Biotech Customized lentivirus for stable overexpression of FLRT2 
                         Customized lentivirus expression plasmids for stable overexpression of FLRT2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FLRT2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FLRT2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FLRT2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FLRT2

    Additional mRNA sequence: 

    AK056649.1 AK297248.1 AY358287.1 BC126249.1 BC130290.1 BC143936.1 

    6 DOTS entries:

    DT.316330  DT.95161958  DT.102830180  DT.120768811  DT.75189686  DT.120768846 

    24/153 AceView cDNA sequences (see all 153):

    CA447439 AW022744 AI865512 AA609504 BQ007659 AI669836 CB216989 AI698999 
    BQ184825 BU737714 BM712308 CA436441 AI076762 BX097136 AL040721 CK906323 
    AA688234 BP345594 AY358287 AA490103 AI149088 W67899 AA411221 BQ082154 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for FLRT2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c
    SP1:                          -           -                 -                                             
    SP2:                          -     -     -     -     -     -                                             
    SP3:                          -     -                                                                     
    SP4:                          -     -     -     -     -     -     -     -     -     -                     
    SP5:                                -     -     -     -     -     -     -     -     -                     


    ECgene alternative splicing isoforms for FLRT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FLRT2 expression in normal human tissues (normalized intensities)      FLRT2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGATACTGCA
    FLRT2 Expression
    About this image


    FLRT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Thalamus
             Substantia Nigra   
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             GABAergic Amacrine Cells Inner Nuclear Layer
             Human corneal endothelial cells
             Human Keratocyte (HK)   
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Human corneal endothelial cells
             blood outgrowth endothelial cell   
     
     Chorion (Extraembryonic Tissues)    fully expand to see all 2 entries
             Human Chorionic Mesenchymal Stromal Cells (HCMSC)   
             chorion villus cells   
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem SM30, NCr-fac & Meso-latp Progenitor
             mesenchyme/trunk mesenchyme   

    See FLRT2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FLRT2

    SOURCE GeneReport for Unigene clusters: Hs.533710 Hs.744139

    UniProtKB/Swiss-Prot: FLRT2_HUMAN, O43155
    Tissue specificity: Expressed in pancreas, skeletal muscle, brain, and heart

        SABiosciences Custom PCR Arrays for FLRT2
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FLRT2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLRT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FLRT2 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Flrt21 , 5 fibronectin leucine rich transmembrane protein 21, 5 89.7(n)1
    97.27(a)1
      12 (46.44 cM)5
    3995581  NM_201518.41  NP_958926.11 
     956922265 
    chicken
    (Gallus gallus)
    Aves FLRT21 fibronectin leucine rich transmembrane protein 2 81.62(n)
    88.33(a)
      428901  XM_003641305.1  XP_003641353.1 
    lizard
    (Anolis carolinensis)
    Reptilia FLRT26
    Uncharacterized protein
    84(a)
    1 ↔ 1
    1(15393538-15395523)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia flrt22 fibronectin leucine rich transmembrane protein 2 80.83(n)    AJ605779.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570858312   -- 74.08(n)    57085831 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tollo6
    Toll-66
    (see all 5)
    Toll-6
    (see all 5)
    6(a)
    5(a)
    (see all 5)
    possible ortholog
    possible ortholog
    (see all 5)
    3L(15228719-15235932)
    3L(15329792-15337417)
    worm
    (Caenorhabditis elegans)
    Secernentea tol-16
    lron-156
    (see all 7)
    Protein LRON-15
    (see all 7)
    8(a)
    7(a)
    (see all 7)
    possible ortholog
    possible ortholog
    (see all 7)
    I(443999-461607)
    II(6540217-6544892)


    ENSEMBL Gene Tree for FLRT2 (if available)
    TreeFam Gene Tree for FLRT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FLRT2 gene
    PODN2  FLRT12  PODNL12  FMOD2  KERA2  PRELP2  FLRT32  OMD2  
    ASPN2  BGN2  DCN2  ECM22  LUM2  
    2 SIMAP similar genes for FLRT2 using alignment to 1 protein entry:     FLRT2_HUMAN:
    FLRT3    FLRT1

    FLRT2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1951 SNPs in FLRT2 are shown (see all 1951)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs610184951,2
    C--66996764(+) TTTTT-/TTT   
      
    /TTTTT
    GGCCT
    1 -- int11NA 2
    rs1510357711,2
    --85998499(+) GCCACA/TGCCCC 1 -- int10--------
    rs1397976101,2
    C--85998672(+) ACCGGA/CCTTGT 1 -- int10--------
    rs1452890151,2
    --85998830(+) GGAAAG/TAGACT 1 -- int10--------
    rs801782781,2
    C--85998880(+) TAGCTG/TTCAAG 1 -- int10--------
    rs2001742771,2
    --85998913(+) GAATC-/TTTCTT 1 -- int10--------
    rs1849353431,2
    --85999463(+) TTAAAA/CCAGAA 1 -- int10--------
    rs680010521,2
    C,F--85999486(+) CTCCGG/AGAGAG 1 -- int16Minor allele frequency- A:0.21WA NA EA 364
    rs675582861,2
    C--85999565(+) AGGGAG/CAGGAG 1 -- int13Minor allele frequency- C:0.17NA EA 242
    rs1890507291,2
    --85999618(+) TAAACA/TTATCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for FLRT2 (85996488 - 86095034 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FLRT2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv85122CNV Insertion16902084

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FLRT2 for disorders           About MalaCards
    OMIM gene information: 604807    OMIM disorders: --


    FLRT2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FLRT2
    Human Genome Epidemiology (HuGE) Navigator: FLRT2 (2 documents)

    Export disorders for FLRT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FLRT2 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with FLRT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins. (PubMed id 10644439)1, 2, 3 Lacy S.E.... Kunkel L.M. (1999)
    2. Sequential use of transcriptional profiling, expressi on quantitative trait mapping, and gene association implicates MMP20 in human k idney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (2009)
    3. Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development. (PubMed id 16872596)1, 3 Haines B.P....Rigby P.W. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2 Ishikawa K....Ohara O. (1997)
    8. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. (PubMed id 23583979)1 den Hoed M....Loos R.J. (2013)
    9. Genome-wide association study of age at menarche in Af rican-American women. (PubMed id 23599027)1 Demerath E.W....Haiman C.A. (2013)
    10. Genome-wide association study of lung function decline in adults with and without asthma. (PubMed id 22424883)1 Imboden M....Probst-Hensch N.M. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23768 HGNC: 3761 AceView: FLRT2 Ensembl:ENSG00000185070 euGenes: HUgn23768
    ECgene: FLRT2 H-InvDB: FLRT2

    (According to HUGE)
    About This Section
    HUGE: KIAA0405

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FLRT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FLRT2 gene:
    Search GeneIP for patents involving FLRT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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