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FLRT1 Gene(Protein Coding)

Fibronectin Leucine Rich Transmembrane Protein 1

GCID:
GC11P064036
GIFtS:
54
Genes Participants
UDN Logo

Aliases for FLRT1 Gene

Aliases for FLRT1 Gene

  • Fibronectin Leucine Rich Transmembrane Protein 1 2 3 5
  • Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 1 3 4
  • SPG68 3

External Ids for FLRT1 Gene

Previous GeneCards Identifiers for FLRT1 Gene

  • GC11M066466
  • GC11M065550
  • GC11P064122
  • GC11P063646
  • GC11P063627
  • GC11P063871
  • GC11P060200

Summaries for FLRT1 Gene

Entrez Gene Summary for FLRT1 Gene

  • This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in kidney and brain. [provided by RefSeq, Jul 2008]

GeneCards Summary for FLRT1 Gene

FLRT1 (Fibronectin Leucine Rich Transmembrane Protein 1) is a Protein Coding gene. Diseases associated with FLRT1 include Autosomal Recessive Spastic Paraplegia Type 68. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Signaling by GPCR. GO annotations related to this gene include protein binding, bridging and receptor signaling protein activity. An important paralog of this gene is ECM2.

UniProtKB/Swiss-Prot for FLRT1 Gene

  • Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases. Promotes neurite outgrowth via FGFR1-mediated activation of downstream MAP kinases. Promotes an increase both in neurite number and in neurite length. May play a role in cell-cell adhesion and cell guidance via its interaction with ADGRL1/LPHN1 and ADGRL3.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLRT1 Gene

Genomics for FLRT1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for FLRT1 Gene

Enhancers for FLRT1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FLRT1 on UCSC Golden Path with GeneCards custom track

Promoters for FLRT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FLRT1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the FLRT1 gene promoter:

Genomic Location for FLRT1 Gene

Chromosome:
11
Start:
64,035,970 bp from pter
End:
64,119,183 bp from pter
Size:
83,214 bases
Orientation:
Plus strand

Genomic View for FLRT1 Gene

Genes around FLRT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FLRT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FLRT1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FLRT1 Gene

Proteins for FLRT1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FLRT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZU1-FLRT1_HUMAN
    Recommended name:
    Leucine-rich repeat transmembrane protein FLRT1
    Protein Accession:
    Q9NZU1
    Secondary Accessions:
    • Q8WVA2

    Protein attributes for FLRT1 Gene

    Size:
    646 amino acids
    Molecular mass:
    71358 Da
    Quaternary structure:
    • Interacts with FGFR1. Interacts (via extracellular domain) with ADGRL1/LPHN1 and ADGRL3 (via olfactomedin-like domain).
    SequenceCaution:
    • Sequence=AAF28459.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH18370.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ88675.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAF82620.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW74194.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FLRT1 Gene

Proteomics data for FLRT1 Gene at MOPED

Protein Expression for FLRT1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FLRT1 Gene

  • N-glycosylated.
  • Phosphorylated in response to FGFR1 signaling, but is not a direct substrate of FGFR1 or SRC. A mutant where the Tyr phosphorylation sites have been replaced by Phe displays constitutive FGFR1-dependent activation of downstream MAP kinases.
  • Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain.
  • Glycosylation at Asn 221 and Asn 277
  • Modification sites at PhosphoSitePlus

Other Protein References for FLRT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for FLRT1
  • Santa Cruz Biotechnology (SCBT) Antibodies for FLRT1

No data available for DME Specific Peptides for FLRT1 Gene

Domains & Families for FLRT1 Gene

Gene Families for FLRT1 Gene

HGNC:

Protein Domains for FLRT1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FLRT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZU1

UniProtKB/Swiss-Prot:

FLRT1_HUMAN :
  • Contains 1 fibronectin type-III domain.
  • Contains 10 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 fibronectin type-III domain.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Similarity:
  • Contains 10 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FLRT1: view

Function for FLRT1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for FLRT1 Gene

GENATLAS Biochemistry:
fibronectin,leucine rich transmembrane protein1,extracellular matrix protein,expressed in kidney and brain
UniProtKB/Swiss-Prot Function:
Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases. Promotes neurite outgrowth via FGFR1-mediated activation of downstream MAP kinases. Promotes an increase both in neurite number and in neurite length. May play a role in cell-cell adhesion and cell guidance via its interaction with ADGRL1/LPHN1 and ADGRL3.

Gene Ontology (GO) - Molecular Function for FLRT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IBA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with FLRT1: view

Phenotypes for FLRT1 Gene

MGI mutant phenotypes for FLRT1:
inferred from 1 alleles
GenomeRNAi human phenotypes for FLRT1:
genes like me logo Genes that share phenotypes with FLRT1: view

Animal Models for FLRT1 Gene

MGI Knock Outs for FLRT1:

Animal Model Products

  • Taconic Biosciences Mouse Models for FLRT1

miRNA for FLRT1 Gene

miRTarBase miRNAs that target FLRT1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FLRT1 Gene

Localization for FLRT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLRT1 Gene

Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane. Cytoplasmic vesicle membrane. Cytoplasm, perinuclear region. Cell junction, focal adhesion. Secreted. Cell projection. Cell junction. Note=In addition to its location at the cell membrane, colocalizes with FGFR1 in punctate perinuclear cytoplasmic vesicles. Detected along neurites and at contacts between neurite termini and other cells. Proteolytic cleavage gives rise to a shedded ectodomain. {ECO:0000250 UniProtKB:Q6RKD8}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FLRT1 Gene COMPARTMENTS Subcellular localization image for FLRT1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 3
peroxisome 2
cytosol 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FLRT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005911 cell-cell junction IEA,ISS --
GO:0005925 colocalizes_with focal adhesion IEA,ISS --
GO:0044306 neuron projection terminus IEA,ISS --
GO:0048471 perinuclear region of cytoplasm IEA,ISS --
genes like me logo Genes that share ontologies with FLRT1: view

Pathways & Interactions for FLRT1 Gene

genes like me logo Genes that share pathways with FLRT1: view

Pathways by source for FLRT1 Gene

Gene Ontology (GO) - Biological Process for FLRT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1904030 negative regulation of cyclin-dependent protein kinase activity IBA --
genes like me logo Genes that share ontologies with FLRT1: view

No data available for SIGNOR curated interactions for FLRT1 Gene

Drugs & Compounds for FLRT1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for FLRT1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for FLRT1 Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(37) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FLRT1 Gene

Fibronectin leucine rich transmembrane protein 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FLRT1 Gene

No ASD Table

Relevant External Links for FLRT1 Gene

GeneLoc Exon Structure for
FLRT1
ECgene alternative splicing isoforms for
FLRT1

Expression for FLRT1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for FLRT1 Gene

mRNA expression in normal human tissues for FLRT1 Gene
mRNA expression by BioGPS for FLRT1 GenemRNA expression by GTEx for FLRT1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FLRT1 Gene



SOURCE GeneReport for Unigene cluster for FLRT1 Gene Hs.584876

mRNA Expression by UniProt/SwissProt for FLRT1 Gene

Q9NZU1-FLRT1_HUMAN
Tissue specificity: Expressed in kidney and brain.
genes like me logo Genes that share expression patterns with FLRT1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for FLRT1 Gene

Orthologs for FLRT1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FLRT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia FLRT1 35
  • 92.76 (n)
  • 95.66 (a)
FLRT1 36
  • 95 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia FLRT1 35
  • 91.05 (n)
  • 96.59 (a)
FLRT1 36
  • 97 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Flrt1 35
  • 89.27 (n)
  • 96.14 (a)
Flrt1 16
Flrt1 36
  • 96 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia FLRT1 35
  • 98.96 (n)
  • 99.7 (a)
FLRT1 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Flrt1 35
  • 89.56 (n)
  • 96.74 (a)
oppossum
(Monodelphis domestica)
 Mammalia -- 36
  • 22 (a)
 ManyToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia FLRT1 36
  • 83 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves -- 36
  • 23 (a)
 ManyToMany
lizard
(Anolis carolinensis)
 Reptilia FLRT1 36
  • 87 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia flrt1 35
  • 71.9 (n)
  • 84.91 (a)
zebrafish
(Danio rerio)
 Actinopterygii flrt1a 35
  • 60.91 (n)
  • 63.61 (a)
flrt1a 36
  • 59 (a)
 OneToMany
flrt1b 36
  • 57 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 35 (a)
 ManyToMany
-- 36
  • 33 (a)
 ManyToMany
Species with no ortholog for FLRT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FLRT1 Gene

ENSEMBL:
Gene Tree for FLRT1 (if available)
TreeFam:
Gene Tree for FLRT1 (if available)

Paralogs for FLRT1 Gene

Paralogs for FLRT1 Gene

(2) SIMAP similar genes for FLRT1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FLRT1: view

Variants for FLRT1 Gene

Structural Variations from Database of Genomic Variants (DGV) for FLRT1 Gene

Variant ID Type Subtype PubMed ID
dgv1155n71 CNV Loss 21882294
dgv1156n71 CNV Loss 21882294
dgv1160n71 CNV Loss 21882294
dgv15n68 CNV Loss 17160897
dgv1162n71 CNV Gain 21882294
nsv469961 CNV Loss 18288195
dgv1163n71 CNV Loss 21882294
nsv356 CNV Loss 18451855
esv2744613 CNV Deletion 23290073

Variation tolerance for FLRT1 Gene

Residual Variation Intolerance Score: 41.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FLRT1 Gene

Human Gene Mutation Database (HGMD)
FLRT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for FLRT1 Gene

Disorders for FLRT1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FLRT1 Gene - From: Orphanet

Disorder Aliases PubMed IDs
autosomal recessive spastic paraplegia type 68
  • spg68
- elite association - COSMIC cancer census association via MalaCards
Search FLRT1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FLRT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FLRT1
genes like me logo Genes that share disorders with FLRT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FLRT1 Gene

Publications for FLRT1 Gene

  1. Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins. (PMID: 10644439) Lacy S.E. … Kunkel L.M. (Genomics 1999) 2 3 4 67
  2. Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. (PMID: 24482476) Novarino G. … Gleeson J.G. (Science 2014) 2 3
  3. Critical role of FLRT1 phosphorylation in the interdependent regulation of FLRT1 function and FGF receptor signalling. (PMID: 20421966) Wheldon L.M. … Heath J.K. (PLoS ONE 2010) 3 23
  4. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L. … Cho J.H. (Nature 2012) 3
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3

Products for FLRT1 Gene

Sources for FLRT1 Gene

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