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Aliases for FLRT1 Gene

Aliases for FLRT1 Gene

  • Fibronectin Leucine Rich Transmembrane Protein 1 2 3
  • Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 1 3 4
  • Leucine-Rich Repeat Transmembrane Protein FLRT1 3
  • SPG68 3

External Ids for FLRT1 Gene

Previous GeneCards Identifiers for FLRT1 Gene

  • GC11M066466
  • GC11M065550
  • GC11P064122
  • GC11P063646
  • GC11P063627
  • GC11P063871
  • GC11P060200

Summaries for FLRT1 Gene

Entrez Gene Summary for FLRT1 Gene

  • This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in kidney and brain. [provided by RefSeq, Jul 2008]

GeneCards Summary for FLRT1 Gene

FLRT1 (Fibronectin Leucine Rich Transmembrane Protein 1) is a Protein Coding gene. Diseases associated with FLRT1 include autosomal recessive spastic paraplegia type 68. GO annotations related to this gene include protein binding, bridging and receptor signaling protein activity. An important paralog of this gene is ECM2.

UniProtKB/Swiss-Prot for FLRT1 Gene

  • May have a function in cell adhesion and/or receptor signaling

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLRT1 Gene

Genomics for FLRT1 Gene

Regulatory Elements for FLRT1 Gene

Genomic Location for FLRT1 Gene

64,035,970 bp from pter
64,119,183 bp from pter
83,214 bases
Plus strand

Genomic View for FLRT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FLRT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FLRT1 Gene

Proteins for FLRT1 Gene

  • Protein details for FLRT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat transmembrane protein FLRT1
    Protein Accession:
    Secondary Accessions:
    • Q8WVA2

    Protein attributes for FLRT1 Gene

    646 amino acids
    Molecular mass:
    71358 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF28459.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH18370.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ88675.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAF82620.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW74194.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FLRT1 Gene

Proteomics data for FLRT1 Gene at MOPED

Post-translational modifications for FLRT1 Gene

Other Protein References for FLRT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for FLRT1

No data available for DME Specific Peptides for FLRT1 Gene

Domains for FLRT1 Gene

Gene Families for FLRT1 Gene

Suggested Antigen Peptide Sequences for FLRT1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 fibronectin type-III domain.
  • Contains 10 LRR (leucine-rich) repeats.
  • Contains 1 fibronectin type-III domain.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
  • Contains 10 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FLRT1: view

Function for FLRT1 Gene

Molecular function for FLRT1 Gene

GENATLAS Biochemistry:
fibronectin,leucine rich transmembrane protein1,extracellular matrix protein,expressed in kidney and brain
UniProtKB/Swiss-Prot Function:
May have a function in cell adhesion and/or receptor signaling

Gene Ontology (GO) - Molecular Function for FLRT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 receptor signaling protein activity NAS 10644439
GO:0005515 protein binding --
GO:0030674 protein binding, bridging NAS 10644439
genes like me logo Genes that share ontologies with FLRT1: view

Phenotypes for FLRT1 Gene

MGI mutant phenotypes for FLRT1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with FLRT1: view

Animal Models for FLRT1 Gene

MGI Knock Outs for FLRT1:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FLRT1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for FLRT1 Gene

Localization for FLRT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLRT1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for FLRT1 Gene COMPARTMENTS Subcellular localization image for FLRT1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
peroxisome 2
cytosol 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FLRT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix NAS 10644439
GO:0005615 extracellular space IEA --
GO:0005887 integral component of plasma membrane NAS 10644439
genes like me logo Genes that share ontologies with FLRT1: view

Pathways for FLRT1 Gene

SuperPathways for FLRT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FLRT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0008150 biological_process ND --
GO:0035556 intracellular signal transduction NAS 10644439
genes like me logo Genes that share ontologies with FLRT1: view

No data available for Pathways by source for FLRT1 Gene

Transcripts for FLRT1 Gene

mRNA/cDNA for FLRT1 Gene

Unigene Clusters for FLRT1 Gene

Fibronectin leucine rich transmembrane protein 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FLRT1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FLRT1 Gene

No ASD Table

Relevant External Links for FLRT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FLRT1 Gene

mRNA expression in normal human tissues for FLRT1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FLRT1 Gene

SOURCE GeneReport for Unigene cluster for FLRT1 Gene Hs.584876

mRNA Expression by UniProt/SwissProt for FLRT1 Gene

Tissue specificity: Expressed in kidney and brain.
genes like me logo Genes that share expressions with FLRT1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Expression partners for FLRT1 Gene

Orthologs for FLRT1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FLRT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FLRT1 35
  • 92.76 (n)
  • 95.66 (a)
FLRT1 36
  • 95 (a)
(Canis familiaris)
Mammalia FLRT1 35
  • 91.05 (n)
  • 96.59 (a)
FLRT1 36
  • 97 (a)
(Mus musculus)
Mammalia Flrt1 35
  • 89.27 (n)
  • 96.14 (a)
Flrt1 16
Flrt1 36
  • 96 (a)
(Pan troglodytes)
Mammalia FLRT1 35
  • 98.96 (n)
  • 99.7 (a)
FLRT1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Flrt1 35
  • 89.56 (n)
  • 96.74 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 22 (a)
(Ornithorhynchus anatinus)
Mammalia FLRT1 36
  • 83 (a)
(Gallus gallus)
Aves -- 36
  • 23 (a)
(Anolis carolinensis)
Reptilia FLRT1 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia flrt1 35
  • 71.9 (n)
  • 84.91 (a)
(Danio rerio)
Actinopterygii flrt1a 35
  • 60.91 (n)
  • 63.61 (a)
flrt1a 36
  • 59 (a)
flrt1b 36
  • 57 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
-- 36
  • 33 (a)
Species with no ortholog for FLRT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FLRT1 Gene

Gene Tree for FLRT1 (if available)
Gene Tree for FLRT1 (if available)

Paralogs for FLRT1 Gene

Paralogs for FLRT1 Gene

(2) SIMAP similar genes for FLRT1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FLRT1: view

Variants for FLRT1 Gene

Structural Variations from Database of Genomic Variants (DGV) for FLRT1 Gene

Variant ID Type Subtype PubMed ID
dgv1155n71 CNV Loss 21882294
dgv1156n71 CNV Loss 21882294
dgv1160n71 CNV Loss 21882294
dgv15n68 CNV Loss 17160897
dgv1162n71 CNV Gain 21882294
nsv469961 CNV Loss 18288195
dgv1163n71 CNV Loss 21882294
nsv356 CNV Loss 18451855
esv2744613 CNV Deletion 23290073

Relevant External Links for FLRT1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for FLRT1 Gene

Disorders for FLRT1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for FLRT1 Gene in MalaCards »

(1) Disease for FLRT1 Gene

genes like me logo Genes that share disorders with FLRT1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FLRT1 Gene

Publications for FLRT1 Gene

  1. Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins. (PMID: 10644439) Lacy S.E. … Kunkel L.M. (Genomics 1999) 2 3 4
  2. Critical role of FLRT1 phosphorylation in the interdependent regulation of FLRT1 function and FGF receptor signalling. (PMID: 20421966) Wheldon L.M. … Heath J.K. (PLoS ONE 2010) 3 23
  3. Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. (PMID: 24482476) Novarino G. … Gleeson J.G. (Science 2014) 2 3
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L. … Cho J.H. (Nature 2012) 3

Products for FLRT1 Gene

Sources for FLRT1 Gene

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