Aliases for FLRT1 Gene
External Ids for FLRT1 Gene
Previous GeneCards Identifiers for FLRT1 Gene
This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in kidney and brain. [provided by RefSeq, Jul 2008]
GeneCards Summary for FLRT1 Gene
FLRT1 (Fibronectin Leucine Rich Transmembrane Protein 1) is a Protein Coding gene. Diseases associated with FLRT1 include autosomal recessive spastic paraplegia type 68. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include protein binding, bridging and receptor signaling protein activity. An important paralog of this gene is ECM2.
UniProtKB/Swiss-Prot for FLRT1 Gene
Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases. Promotes neurite outgrowth via FGFR1-mediated activation of downstream MAP kinases. Promotes an increase both in neurite number and in neurite length. May play a role in cell-cell adhesion and cell guidance via its interaction with ADGRL1/LPHN1 and ADGRL3.