FLRT1 Gene
protein-coding GIFtS: 53
GCID: GC11P063871
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|
fibronectin leucine rich transmembrane protein 1
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Aliases
for FLRT1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fibronectin Leucine Rich Transmembrane Protein 11 2 | | Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 12 3 | | MGC216241 | | Leucine-Rich Repeat Transmembrane Protein FLRT12 |
Export aliases for FLRT1 gene to outside databasesPrevious GC identifers: GC11M066466 GC11M065550 GC11P064122 GC11P063646 GC11P063627 GC11P060200 |
Summaries
for FLRT1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FLRT1:
This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members mayfunction in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-richproteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other familymembers, FLRT2 and FLRT3. This gene is expressed in kidney and brain. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: FLRT1_HUMAN, Q9NZU1Function: May have a function in cell adhesion and/or receptor signaling
|
Genomic Views
for FLRT1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FLRT1 gene promoter:
COUP-TF1 Bach1 Egr-1 COUP HNF-4alpha2 HNF-4alpha1 FOXL1 S8 COUP-TF FOXO4
Other transcription factors
Search SABiosciences Chromatin IP Primers for FLRT1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FLRT1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q12-q13 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q12-q13FLRT1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P063871: view genomic region
(about GC identifiers)
Start:
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63,870,660 bp from pter |
End:
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63,886,645 bp from pter |
Size:
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15,986 bases |
Orientation:
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plus strand |
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Proteins
for FLRT1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FLRT1_HUMAN, Q9NZU1 (See
protein sequence)Recommended Name: Leucine-rich repeat transmembrane protein FLRT1 precursor Size: 646 amino acids; 71358 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Probable)
Sequence caution: Sequence=AAF28459.1; Type=Erroneous initiation; Sequence=AAH18370.1; Type=Erroneous initiation;Sequence=AAQ88675.1; Type=Erroneous initiation; Sequence=BAF82620.1; Type=Erroneous initiation; Sequence=EAW74194.1;Type=Erroneous initiation;
Secondary accessions: Q8WVA2Explore the universe of human proteins at neXtProt for FLRT1: NX_Q9NZU1
Post-translational modifications:
N-glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NZU1
FLRT1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_037412.2
ENSEMBL proteins: ENSP00000246841
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
FLRT1 for ontologies About GeneDecksing
FLRT1 Antibody Products:
Assay Products for FLRT1: |
Protein
Domains /
Families
for FLRT1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FLRT1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9NZU1ProtoNet protein and cluster: Q9NZU1 2 Blocks protein families: IPB000372 Cysteine-rich flanking region IPB000483 Cysteine-rich flanking region
UniProtKB/Swiss-Prot: FLRT1_HUMAN, Q9NZU1Similarity: Contains 1 fibronectin type-III domainSimilarity: Contains 10 LRR (leucine-rich) repeatsSimilarity: Contains 1 LRRCT domainSimilarity: Contains 1 LRRNT domain |
Function
for FLRT1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FLRT1_HUMAN, Q9NZU1Function: May have a function in cell adhesion and/or receptor signaling Genatlas biochemistry entry for FLRT1:fibronectin,leucine rich transmembrane protein1,extracellular matrix protein,expressed in kidney and brain
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FLRT1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FLRT1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for FLRT1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLRT1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLRT1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
FLRT1 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Flrt1tm1Lex for FLRT1
1 MGI phenotypic allele  for Flrt1 (no phenotypes)
FLRT1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for FLRT1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FLRT1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for FLRT1 (Q9NZU12, 3 ENSP000002468414) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007155 | cell adhesion |
IEA | -- | | GO:0008150 | biological_process |
ND | -- |
FLRT1 for ontologies About GeneDecksing
|
Drugs & Compounds
for FLRT1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FLRT1
Search CenterWatch for drugs/clinical trials and news about FLRT1
|
Transcripts
for FLRT1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FLRT1 gene: NM_013280.4 Unigene Cluster for FLRT1: Fibronectin leucine rich transmembrane protein 1 Hs.584876 [show with all ESTs]Unigene Representative Sequence: AY3583081 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000246841(uc001nyi.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FLRT1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FLRT1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FLRT1 (NM_013280) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FLRT1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLRT1 |
Additional cDNA sequence: AF007139.1 AF169675.1 AK289931.1 AY358308.1 BC018370.1 3 DOTS entries: DT.97770464 DT.210792 DT.120741897 24/37 AceView cDNA sequences (see all 37): F04546 AI494233 BX951900 BM710660 Z40799 BM715659 AY358308 F08324 Z45074 NM_013280 AF007139 BF530310 BM728867 AF169675 BC018370 BM674096 BU742770 CD624700 CD624699 BM667377 BX090702 BF437742 AI362924 BI601883
GeneLoc Exon Structure
|
Expression
for FLRT1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FLRT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGTCGATTA
About this image
See FLRT1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FLRT1
SOURCE GeneReport for Unigene cluster: Hs.584876
UniProtKB/Swiss-Prot: FLRT1_HUMAN, Q9NZU1Tissue specificity: Expressed in kidney and brain
SABiosciences Custom PCR Arrays for FLRT1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FLRT1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FLRT1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FLRT1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FLRT1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLRT1 |
Orthologs
for FLRT1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FLRT1 gene from 4/15 species (see all 15) About this table
ENSEMBL Gene Tree for FLRT1 (if available)
TreeFam Gene Tree for FLRT1 (if available) |
Paralogs
for FLRT1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FLRT1 gene
- GP52 CPN22 LRIG32 LRRTM42 CHAD2 FLRT32 LRRC152 LRIG22
- LRRTM32 IGFALS2 CHADL2 LRIG12 LRRTM22 FLRT22 VASN2 LRRTM12
2 SIMAP similar genes for FLRT1 using alignment to 1 protein entry: FLRT1_HUMAN:FLRT3 FLRT2
FLRT1 for paralogs About GeneDecksing
|
Genomic Variants
for FLRT1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FLRT1 (63870660 - 63886645 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FLRT1
2 CNVs: 4750 4751 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FLRT1 |
|
Disorders
/ Diseases
for FLRT1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 FLRT1 for disorders About MalaCards
FLRT1 for disorders About GeneDecksing
OMIM gene information: 604806
OMIM disorders: --
Export disorders for FLRT1 gene to outside databases
|
Publications
for FLRT1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FLRT1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FLRT1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins. (PubMed id 10644439)1, 2, 3 Lacy S.E.... Kunkel L.M. (1999)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Critical role of FLRT1 phosphorylation in the interde pendent regulation of FLRT1 function and FGF receptor signalling. (PubMed id 20421966)1, 9 Wheldon L.M....Heath J.K. (2010)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (1997)
- A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1 Andersson B.... Gibbs R.A. (1996)
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External Searches for FLRT1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FLRT1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FLRT1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FLRT1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for FLRT1 gene:
Search GeneIP for patents involving FLRT1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FLRT1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for FLRT1 | | OriGene shRNA RFP for FLRT1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FLRT1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FLRT1 | | | OriGene Protein Over-expression Lysate for FLRT1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FLRT1 | | OriGene 3'-UTR Clone for FLRT1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FLRT1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FLRT1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FLRT1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FLRT1 | | OriGene Custom Protein Services for FLRT1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FLRT1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FLRT1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FLRT1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FLRT1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FLRT1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FLRT1 |
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| | | | Search Tocris compounds for FLRT1 |
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 | | | FLRT1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLRT1 |
|  |  |  | | | | ThermoFisher Antibody for FLRT1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLRT1 |
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