Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FLOT2 Gene

Aliases for FLOT2 Gene

  • Flotillin 2 2 3
  • M17S1 3 4 6
  • ESA1 3 4 6
  • Membrane Component Chromosome 17 Surface Marker 1 3 4
  • Flotillin 2 (Epidermal Surface Antigen 1) 2 3
  • Epidermal Surface Antigen 3 4
  • ECS1 3 6
  • ESA 3 4
  • Membrane Component, Chromosome 17, Surface Marker 1 (35kD Protein Identified By Monoclonal Antibody ECS-1) 3
  • Surface Marker 1 (35kD Protein Identified By Monoclonal Antibody ECS-1) 2
  • Membrane Component 2
  • Chromosome 17 2
  • Flotillin-2 3
  • ECS-1 3

External Ids for FLOT2 Gene

Previous HGNC Symbols for FLOT2 Gene

  • M17S1

Previous GeneCards Identifiers for FLOT2 Gene

  • GC17M027051
  • GC17M029105
  • GC17M027351
  • GC17M024230
  • GC17M027206
  • GC17M023414

Summaries for FLOT2 Gene

Entrez Gene Summary for FLOT2 Gene

  • Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling. [provided by RefSeq, Jul 2008]

GeneCards Summary for FLOT2 Gene

FLOT2 (Flotillin 2) is a Protein Coding gene. Diseases associated with FLOT2 include toxic megacolon and megacolon. Among its related pathways are Cytoskeletal Signaling and Insulin Signaling. GO annotations related to this gene include ionotropic glutamate receptor binding. An important paralog of this gene is FLOT1.

UniProtKB/Swiss-Prot for FLOT2 Gene

  • May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function

Gene Wiki entry for FLOT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLOT2 Gene

Genomics for FLOT2 Gene

Regulatory Elements for FLOT2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FLOT2 Gene

Start:
28,879,335 bp from pter
End:
28,897,697 bp from pter
Size:
18,363 bases
Orientation:
Minus strand

Genomic View for FLOT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FLOT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FLOT2 Gene

Proteins for FLOT2 Gene

  • Protein details for FLOT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14254-FLOT2_HUMAN
    Recommended name:
    Flotillin-2
    Protein Accession:
    Q14254
    Secondary Accessions:

    Protein attributes for FLOT2 Gene

    Size:
    428 amino acids
    Molecular mass:
    47064 Da
    Quaternary structure:
    • Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2 (By similarity). Interacts with ECM29.
    SequenceCaution:
    • Sequence=AAA65729.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FLOT2 Gene

Proteomics data for FLOT2 Gene at MOPED

Post-translational modifications for FLOT2 Gene

  • ZDHHC5-catalyzed palmitoylation predominantly occurs at Cys-4. ZDHHC5-catalyzed palmitoylation may be required for the formation of higher-order complexes and for neurite outgrowth in cultured neural stem cells.
  • Ubiquitination at Lys81, Lys100, Lys160, Lys169, and Lys370
  • Modification sites at PhosphoSitePlus

Other Protein References for FLOT2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FLOT2 (FLOT2)

No data available for DME Specific Peptides for FLOT2 Gene

Domains for FLOT2 Gene

Protein Domains for FLOT2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FLOT2 Gene

Graphical View of Domain Structure for InterPro Entry

Q14254

UniProtKB/Swiss-Prot:

FLOT2_HUMAN :
  • Q14254
Family:
  • Belongs to the band 7/mec-2 family. Flotillin subfamily.
genes like me logo Genes that share domains with FLOT2: view

No data available for Gene Families for FLOT2 Gene

Function for FLOT2 Gene

Molecular function for FLOT2 Gene

GENATLAS Biochemistry: flotillin 2,35kDa,resident integral membrane protein of caveolae from epithelial surface, involved in cell adhesion
UniProtKB/Swiss-Prot Function: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function

Gene Ontology (GO) - Molecular Function for FLOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IEA --
GO:0005515 protein binding IPI 17113085
GO:0035255 ionotropic glutamate receptor binding IEA --
genes like me logo Genes that share ontologies with FLOT2: view

Phenotypes for FLOT2 Gene

genes like me logo Genes that share phenotypes with FLOT2: view

Animal Models for FLOT2 Gene

MGI Knock Outs for FLOT2:

Animal Model Products

miRNA for FLOT2 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FLOT2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FLOT2 Gene

Localization for FLOT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLOT2 Gene

Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Endosome. Note=Membrane-associated protein of caveolae.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FLOT2 Gene COMPARTMENTS Subcellular localization image for FLOT2 gene
Compartment Confidence
endosome 5
plasma membrane 5
cytoskeleton 2
cytosol 2
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for FLOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002080 acrosomal membrane IEA --
GO:0005768 endosome IDA 20682791
GO:0005886 plasma membrane NAS 1769667
GO:0005901 caveola IDA 24013648
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with FLOT2: view

Pathways for FLOT2 Gene

genes like me logo Genes that share pathways with FLOT2: view

Pathways by source for FLOT2 Gene

1 Qiagen pathway for FLOT2 Gene
1 Cell Signaling Technology pathway for FLOT2 Gene
1 BioSystems pathway for FLOT2 Gene
1 KEGG pathway for FLOT2 Gene

Gene Ontology (GO) - Biological Process for FLOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0008544 epidermis development TAS 8051082
GO:0010629 negative regulation of gene expression IMP 24612608
GO:0050821 protein stabilization IMP 24612608
GO:0090002 establishment of protein localization to plasma membrane IMP 24612608
genes like me logo Genes that share ontologies with FLOT2: view

Compounds for FLOT2 Gene

(4) Novoseek inferred chemical compound relationships for FLOT2 Gene

Compound -log(P) Hits PubMed IDs
lipid 53.7 12
cholesterol 42.7 6
sucrose 19.7 2
tyrosine 0 1
genes like me logo Genes that share compounds with FLOT2: view

Transcripts for FLOT2 Gene

Unigene Clusters for FLOT2 Gene

Flotillin 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FLOT2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FLOT2 Gene

No ASD Table

Relevant External Links for FLOT2 Gene

GeneLoc Exon Structure for
FLOT2
ECgene alternative splicing isoforms for
FLOT2

Expression for FLOT2 Gene

mRNA expression in normal human tissues for FLOT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FLOT2 Gene

This gene is overexpressed in Whole Blood (16.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FLOT2 Gene

SOURCE GeneReport for Unigene cluster for FLOT2 Gene Hs.514038

mRNA Expression by UniProt/SwissProt for FLOT2 Gene

Q14254-FLOT2_HUMAN
Tissue specificity: In skin, expressed in epidermis and epidermal appendages but not in dermis. Expressed in all layers of the epidermis except the basal layer. In hair follicles, expressed in the suprabasal layer but not the basal layer. Also expressed in melanoma and carcinoma cell lines, fibroblasts and foreskin melanocytes
genes like me logo Genes that share expressions with FLOT2: view

In Situ Assay Products

Orthologs for FLOT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FLOT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FLOT2 35
  • 99.61 (n)
  • 100 (a)
FLOT2 36
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FLOT2 35
  • 92.52 (n)
  • 98.6 (a)
FLOT2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FLOT2 35
  • 92.33 (n)
  • 99.3 (a)
FLOT2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Flot2 35
  • 90.65 (n)
  • 99.07 (a)
Flot2 16
Flot2 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FLOT2 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FLOT2 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Flot2 35
  • 88.79 (n)
  • 96.96 (a)
chicken
(Gallus gallus)
Aves FLOT2 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FLOT2 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia flot2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia flot2 35
  • 76.13 (n)
  • 86.15 (a)
Str.3461 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9615 35
zebrafish
(Danio rerio)
Actinopterygii flot2a 36
  • 81 (a)
OneToMany
flot2b 35
  • 73.15 (n)
  • 81.03 (a)
flot2b 36
  • 81 (a)
OneToMany
zgc64103 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003789 35
  • 64.75 (n)
  • 65.66 (a)
fruit fly
(Drosophila melanogaster)
Insecta Flo-2 35
  • 65.06 (n)
  • 66.35 (a)
Flo-2 36
  • 62 (a)
OneToOne
Flo-2 37
  • 65 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2729 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8302 36
  • 65 (a)
OneToOne
Species with no ortholog for FLOT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FLOT2 Gene

ENSEMBL:
Gene Tree for FLOT2 (if available)
TreeFam:
Gene Tree for FLOT2 (if available)

Paralogs for FLOT2 Gene

Paralogs for FLOT2 Gene

Selected SIMAP similar genes for FLOT2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with FLOT2: view

Variants for FLOT2 Gene

Sequence variations from dbSNP and Humsavar for FLOT2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs9617 -- 28,879,510(-) CAAGC(A/C/G)TCTTG utr-variant-3-prime
rs10205 -- 28,880,102(-) GTCCT(C/T)TCTCC utr-variant-3-prime
rs14117 -- 28,879,611(-) TGCCA(A/T)CTTTC utr-variant-3-prime
rs1060244 -- 28,880,553(-) CTCCT(A/G)CAGGC utr-variant-3-prime
rs1060247 -- 28,880,435(-) TGCTG(C/T)GTGTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FLOT2 Gene

Variant ID Type Subtype PubMed ID
nsv457719 CNV Loss 19166990

Relevant External Links for FLOT2 Gene

HapMap Linkage Disequilibrium report
FLOT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLOT2 Gene

Disorders for FLOT2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for FLOT2 Gene including...

Search for FLOT2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for FLOT2 Gene

Relevant External Links for FLOT2

Human Genome Epidemiology (HuGE) Navigator
FLOT2
genes like me logo Genes that share disorders with FLOT2: view

No data available for UniProtKB/Swiss-Prot for FLOT2 Gene

Publications for FLOT2 Gene

  1. The human gene for an epidermal surface antigen (M17S1) is located at 17q11-12. (PMID: 1769667) Schroeder W.T. … Duvic M. (Genomics 1991) 2 3 23
  2. Cloning and characterization of a novel epidermal cell surface antigen (ESA). (PMID: 8051082) Schroeder W.T. … Duvic M. (J. Biol. Chem. 1994) 3 4 23
  3. Flotillin 2 is distinct from epidermal surface antigen (ESA) and is associated with filopodia formation. (PMID: 10462713) Hazarika P. … Duvic M. (J. Cell. Biochem. 1999) 3 23
  4. Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts. (PMID: 11159550) Salzer U. … Prohaska R. (Blood 2001) 3 23
  5. Linking membrane microdomains to the cytoskeleton: regulation of the lateral mobility of reggie-1/flotillin-2 by interaction with actin. (PMID: 17854803) Langhorst M.F. … Stuermer C.A. (FEBS Lett. 2007) 3 23

Products for FLOT2 Gene

Sources for FLOT2 Gene

Back to Top

Content