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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FLOT2 Gene

protein-coding   GIFtS: 61
GCID: GC17M027206

Flotillin 2


(Previous symbol: M17S1)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Flotillin 21 2     ECS12 5
M17S11 2 3 5     Chromosome 171
ESA12 3 5     Membrane Component1
Flotillin 2 (Epidermal Surface Antigen 1)1 2     Surface Marker 1 (35kD Protein Identified By Monoclonal Antibody ECS-1)1
Epidermal Surface Antigen2 3     ECS-12
Membrane Component Chromosome 17 Surface Marker 12 3     flotillin-22
ESA2 3     Membrane Component, Chromosome 17, Surface Marker 1 (35kD Protein
Identified By Monoclonal Antibody ECS-1)2

External Ids:    HGNC: 37581   Entrez Gene: 23192   Ensembl: ENSG000001325897   OMIM: 1315605   UniProtKB: Q142543   

Export aliases for FLOT2 gene to outside databases

Previous GC identifers: GC17M027051 GC17M029105 GC17M027351 GC17M024230 GC17M023414


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FLOT2 Gene:
Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction.
This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal
signaling. (provided by RefSeq, Jul 2008)

GeneCards Summary for FLOT2 Gene: 
FLOT2 (flotillin 2) is a protein-coding gene. Diseases associated with FLOT2 include toxic megacolon, and megacolon, and among its related super-pathways are Erythropoietin Pathway and Regulation of lipid metabolism Insulin signaling-generic cascades. GO annotations related to this gene include ionotropic glutamate receptor binding. An important paralog of this gene is FLOT1.

UniProtKB/Swiss-Prot: FLOT2_HUMAN, Q14254
Function: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of
caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and
function

Gene Wiki entry for FLOT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010799.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FLOT2 gene promoter:
         AhR   Sox5   HSF1 (long)   AP-4   CUTL1   Arnt   PPAR-gamma1   HSF1short   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFLOT2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FLOT2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FLOT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11-q12   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11-q12

FLOT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FLOT2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M027206:  view genomic region     (about GC identifiers)

Start:
27,206,353 bp from pter      End:
27,224,715 bp from pter
Size:
18,363 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FLOT2_HUMAN, Q14254 (See protein sequence)
Recommended Name: Flotillin-2  
Size: 428 amino acids; 47064 Da
Subunit: Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2 (By similarity).
Interacts with ECM29
Subcellular location: Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein.
Endosome. Note=Membrane-associated protein of caveolae
Sequence caution: Sequence=AAA65729.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Explore the universe of human proteins at neXtProt for FLOT2: NX_Q14254

Explore proteomics data for FLOT2 at MOPED 

Post-translational modifications:

  • UniProtKB: ZDHHC5-catalyzed palmitoylation predominantly occurs at Cys-4. ZDHHC5-catalyzed palmitoylation may be required for
    the formation of higher-order complexes and for neurite outgrowth in cultured neural stem cells
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14254

  • FLOT2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FLOT2 Protein Expression
    REFSEQ proteins: NP_004466.2  
    ENSEMBL proteins: 
     ENSP00000378366   ENSP00000378368   ENSP00000463304   ENSP00000463503   ENSP00000465022  
     ENSP00000465819  

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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for FLOT2 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002080acrosomal membrane IEA--
    GO:0005768endosome IDA--
    GO:0005886plasma membrane NAS1769667
    GO:0005901caveola ----
    GO:0009986cell surface IDA12493773

    FLOT2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR001107 Band_7

    Graphical View of Domain Structure for InterPro Entry Q14254

    ProtoNet protein and cluster: Q14254

    1 Blocks protein domain: IPB004851 Flotillin

    UniProtKB/Swiss-Prot: FLOT2_HUMAN, Q14254
    Similarity: Belongs to the band 7/mec-2 family. Flotillin subfamily


    FLOT2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FLOT2_HUMAN, Q14254
    Function: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of
    caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and
    function

         Genatlas biochemistry entry for FLOT2:
    flotillin 2,35kDa,resident integral membrane protein of caveolae from epithelial surface, involved in cell
    adhesion

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17113085
    GO:0035255ionotropic glutamate receptor binding IEA--
         
    FLOT2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FLOT2:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Flot2):
     behavior/neurological 

    FLOT2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FLOT2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FLOT2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FLOT2 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidFLOT2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLOT2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FLOT2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Erythropoietin Pathway
    Insulin Receptor Pathway0.37
    2Translation Insulin regulation of translation
    Insulin signaling pathway0.31
    3Insulin Signaling
    Insulin Signaling
    4Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for FLOT2
        Insulin Receptor Pathway

    1 Cell Signaling Technology (CST) Pathway for FLOT2
        Cytoskeletal Signaling

    1 BioSystems Pathway for FLOT2
        Insulin Signaling


    1         Kegg Pathway  (Kegg details for FLOT2):
        Insulin signaling pathway


    FLOT2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FLOT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/31 Interacting proteins for FLOT2 (Q142542, 3 ENSP000003783684) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206346O779322, 3, ENSP000003828194MINT-62761 MINT-62587 MINT-62685 I2D: score=4 STRING: ENSP00000382819
    ENSG00000234798O779322, 3, ENSP000003913494MINT-62761 MINT-62587 MINT-62685 I2D: score=4 STRING: ENSP00000391349
    DXOO779322, 3, ENSP000003377594MINT-62761 MINT-62587 MINT-62685 I2D: score=4 STRING: ENSP00000337759
    ENSG00000236765O779322, 3, ENSP000003911234MINT-62761 MINT-62587 MINT-62685 I2D: score=4 STRING: ENSP00000391123
    ENSG00000224313O779322, 3MINT-62761 MINT-62587 MINT-62685 I2D: score=4 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0008544epidermis development TAS8051082

    FLOT2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FLOT2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FLOT2

    4 Novoseek inferred chemical compound relationships for FLOT2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipid 53.7 13 18296650 (2), 19542222 (1), 16546137 (1), 11999340 (1) (see all 11)
    cholesterol 42.7 8 16038619 (2), 19542222 (1), 20339840 (1), 14670987 (1) (see all 5)
    sucrose 19.7 2 16038619 (1), 18316074 (1)
    tyrosine 0 1 17213334 (1)

    Search CenterWatch for drugs/clinical trials and news about FLOT2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FLOT2 gene: 
    NM_004475.2  

    Unigene Cluster for FLOT2:

    Flotillin 2
    Hs.514038  [show with all ESTs]
    Unigene Representative Sequence: NM_004475
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394906 ENST00000394908(uc002hdc.3) ENST00000580805 ENST00000584569
    ENST00000577789 ENST00000585169 ENST00000586827 ENST00000465427 ENST00000593158
    ENST00000580313 ENST00000582174 ENST00000581509

    miRNA
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    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate FLOT2 (see all 22):
    hsa-miR-3910 hsa-miR-125a-5p hsa-miR-148b hsa-miR-146a hsa-miR-486-3p hsa-miR-449a hsa-miR-103a hsa-miR-124
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    Additional mRNA sequence: 

    AK225491.1 BC003683.1 BC017292.1 BT019477.1 BT019478.1 CR541784.1 CR542265.1 M60922.1 

    17 DOTS entries:

    DT.453006  DT.100660777  DT.97855308  DT.100660787  DT.95262668  DT.120984952  DT.95262685  DT.100031390 
    DT.75189310  DT.100759753  DT.92395626  DT.92461840  DT.92461852  DT.95262675  DT.95262676  DT.97824361 
    DT.95262679 

    24/565 AceView cDNA sequences (see all 565):

    CA308376 AI141437 AA322599 CR597091 BQ009647 AI675851 BU541464 AI802293 
    BM917069 BM786669 BQ108562 BM722228 BQ015384 BU542095 BU540501 BM914621 
    AI305836 AI380864 BM917108 CA455346 BF569227 BC003683 NM_144683 BU187307 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FLOT2 expression in normal human tissues (normalized intensities)      FLOT2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGGTCTGG
    FLOT2 Expression
    About this image


    FLOT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/28 selected tissues (see all 28) fully expand
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             neutrophils   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, post-menopause ; glandular cells   

    See FLOT2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FLOT2

    SOURCE GeneReport for Unigene cluster: Hs.514038

    UniProtKB/Swiss-Prot: FLOT2_HUMAN, Q14254
    Tissue specificity: In skin, expressed in epidermis and epidermal appendages but not in dermis. Expressed in all
    layers of the epidermis except the basal layer. In hair follicles, expressed in the suprabasal layer but not the
    basal layer. Also expressed in melanoma and carcinoma cell lines, fibroblasts and foreskin melanocytes

        SABiosciences Custom PCR Arrays for FLOT2
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLOT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FLOT2 gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Flot21 , 5 flotillin 21, 5 90.73(n)1
    99.3(a)1
      11 (46.74 cM)5
    142521  NM_001040403.11  NP_001035493.11 
     780379315 
    chicken
    (Gallus gallus)
    Aves FLOT21 flotillin 2 80.45(n)
    87.5(a)
      417579  NM_001030719.1  NP_001025890.1 
    lizard
    (Anolis carolinensis)
    Reptilia FLOT26
    flotillin 2
    85(a)
    1 ↔ 1
    GL344223.1(29224-63220)
    African clawed frog
    (Xenopus laevis)
    Amphibia flot2-prov2 flotillin 2 75.64(n)    BC043770.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc641032 hypothetical protein MGC64103 75.41(n)   393612  BC057431.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Flo-21 , 3 cell adhesion structural molecule3
    flotillin 21
    65(a)3
    65.22(n)1
    66.35(a)1
      324251  NM_078602.21  NP_511157.21 


    ENSEMBL Gene Tree for FLOT2 (if available)
    TreeFam Gene Tree for FLOT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FLOT2 gene
    FLOT12  
    1 SIMAP similar gene for FLOT2 using alignment to 8 protein entries:     FLOT2_HUMAN (see all proteins):
    FLOT1

    FLOT2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/349 SNPs in FLOT2 are shown (see all 349)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1864521131,2
    --27205899(+) AGCCTA/GAGAGA 1 -- ds50010--------
    rs1431356501,2
    --27205937(+) TATACC/TGGTAC 1 -- ds50010--------
    rs1913440131,2
    --27205982(+) TTTCTC/TCTTTT 1 -- ds50010--------
    rs1160020111,2
    --27205986(+) TTCTTC/TTTTTT 1 -- ds50010--------
    rs72132851,2
    C,F,A--27206029(+) ggctgG/Aactca 1 -- ds50019Minor allele frequency- A:0.10NA WA EA 370
    rs1836594281,2
    --27206034(+) GACTCA/CAACTC 1 -- ds50010--------
    rs99030241,2
    C,F--27206080(+) agtagC/Atggga 1 -- ds50011Minor allele frequency- A:0.04WA 118
    rs1873535661,2
    --27206316(+) TTCTCA/GGTTCG 1 -- ds50010--------
    rs10603511,2
    C--27206385(-) CCCTTC/TTGGTA 1 -- ut313Minor allele frequency- T:0.00MN NA 188
    rs10603431,2
    C--27206425(-) CTGGTC/TTGGGG 1 -- ut312Minor allele frequency- T:0.00MN NA 186

    HapMap Linkage Disequilibrium report for FLOT2 (27206353 - 27224715 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FLOT2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv457719CNV Loss19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 131560    OMIM disorders: --

    11 diseases for FLOT2:    About MalaCards
    toxic megacolon    megacolon    choroiditis    nasopharyngitis
    colon cancer    myeloma    retinitis    alzheimer's disease
    neuronitis    melanoma    thyroiditis

    1 disease from the University of Copenhagen DISEASES database for FLOT2:
    Toxic megacolon

    FLOT2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Human Genome Epidemiology (HuGE) Navigator: FLOT2 (1 document)

    Export disorders for FLOT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FLOT2 gene, integrated from 9 sources (see all 93):
    (articles sorted by number of sources associating them with FLOT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel epidermal cell surface antigen (ESA). (PubMed id 8051082)1, 2, 9 Schroeder W.T.... Duvic M. (1994)
    2. The human gene for an epidermal surface antigen (M17S1) is located at 17q11-12. (PubMed id 1769667)1, 3, 9 Schroeder W.T....Duvic M. (1991)
    3. DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells. (PubMed id 22081607)1, 2 Li Y.... Hofmann S.L. (2012)
    4. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PubMed id 20682791)1, 2 Gorbea C.... Rechsteiner M. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Flotillin 2 is distinct from epidermal surface antigen (ESA) and is associated with filopodia formation. (PubMed id 10462713)1, 9 Hazarika P....Duvic M. (1999)
    7. The lipid raft microdomain-associated protein reggie-1/flotillin-2 is expressed in human B cells and localized at the plasma membrane and centrosome in PBMCs. (PubMed id 11999340)1, 9 Solomon S....Illges H. (2002)
    8. Identification of flotillin-2, a major protein on lipid rafts, as a novel target of p53 family members. (PubMed id 18296650)1, 9 Sasaki Y....Tokino T. (2008)
    9. Linking membrane microdomains to the cytoskeleton: regulation of the lateral mobility of reggie-1/flotillin-2 by interaction with actin. (PubMed id 17854803)1, 9 Langhorst M.F....Stuermer C.A. (2007)
    10. Hetero-oligomerization of reggie-1/flotillin-2 and reggie-2/flotillin-1 is required for their endocytosis. (PubMed id 19318123)1, 9 Babuke T....Tikkanen R. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2319 HGNC: 3758 AceView: FLOT2andMGC23280 Ensembl:ENSG00000132589 euGenes: HUgn2319
    ECgene: FLOT2 Kegg: 2319 H-InvDB: FLOT2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FLOT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FLOT2 gene:
    Search GeneIP for patents involving FLOT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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