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Aliases for FLOT2 Gene

Aliases for FLOT2 Gene

  • Flotillin 2 2 3 5
  • Membrane Component, Chromosome 17, Surface Marker 1 (35kD Protein Identified By Monoclonal Antibody ECS-1) 2 3
  • Membrane Component Chromosome 17 Surface Marker 1 3 4
  • Flotillin 2 (Epidermal Surface Antigen 1) 2 3
  • Epidermal Surface Antigen 3 4
  • M17S1 3 4
  • ESA1 3 4
  • ESA 3 4
  • Flotillin-2 3
  • ECS-1 3
  • ECS1 3

External Ids for FLOT2 Gene

Previous HGNC Symbols for FLOT2 Gene

  • M17S1

Previous GeneCards Identifiers for FLOT2 Gene

  • GC17M027051
  • GC17M029105
  • GC17M027351
  • GC17M024230
  • GC17M027206
  • GC17M023414
  • GC17M028880
  • GC17M028881

Summaries for FLOT2 Gene

Entrez Gene Summary for FLOT2 Gene

  • Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling. [provided by RefSeq, Jul 2008]

GeneCards Summary for FLOT2 Gene

FLOT2 (Flotillin 2) is a Protein Coding gene. Among its related pathways are Beta-Adrenergic Signaling and Protein-protein interactions at synapses. GO annotations related to this gene include protease binding and ionotropic glutamate receptor binding. An important paralog of this gene is FLOT1.

UniProtKB/Swiss-Prot for FLOT2 Gene

  • May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.

Gene Wiki entry for FLOT2 Gene

Additional gene information for FLOT2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLOT2 Gene

Genomics for FLOT2 Gene

Regulatory Elements for FLOT2 Gene

Enhancers for FLOT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H028936 1.7 FANTOM5 Ensembl ENCODE dbSUPER 27.2 -39.6 -39608 1 ELF3 FOXA2 ARID4B YY1 ATF7 CREM MIXL1 THAP11 CEBPB MIER2 FLOT2 PHF12 DHRS13 TIAF1 NUFIP2 UNC119 SDF2 TAOK1 ENSG00000265908 LOC101927018
GH17H028923 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13.3 -28.4 -28367 4 PKNOX1 ATF1 FEZF1 ZNF766 FOS ATF7 RUNX3 PAF1 NCOA1 JUNB PHF12 FLOT2 DHRS13 ERAL1 FAM222B SEZ6 SUPT6H NUFIP2 SNORD42A SNORD4A
GH17H028863 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.5 +32.4 32361 3 HDGF ARNT ARID4B ZNF766 CBX5 ZC3H11A JUNB REST SMARCB1 ZNF592 DHRS13 PROCA1 FLOT2 TLCD1 NEK8 SNORD4B SNORD42A RPL23A RAB34 SNORD42B
GH17H028807 1.6 FANTOM5 ENCODE dbSUPER 11.5 +87.3 87258 6 HDGF FOXA2 PKNOX1 ARNT SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 SUPT6H TRAF4 LOC101927018 ENSG00000264577 ENSG00000265205 NUFIP2 ENSG00000265908 FAM222B ERAL1 PIGS
GH17H028870 1.3 Ensembl ENCODE dbSUPER 12.4 +26.1 26055 1 PKNOX1 BATF MTA3 ZNF316 POLR2A NFE2 ETV6 RUNX3 IKZF2 SRF FLOT2 DHRS13 MYO18A ENSG00000264066 ENSG00000264304
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FLOT2 on UCSC Golden Path with GeneCards custom track

Promoters for FLOT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000092780 397 1401 ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207 SP3 SP5 REST ZNF592

Genomic Location for FLOT2 Gene

Chromosome:
17
Start:
28,879,335 bp from pter
End:
28,897,697 bp from pter
Size:
18,363 bases
Orientation:
Minus strand

Genomic View for FLOT2 Gene

Genes around FLOT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FLOT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FLOT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FLOT2 Gene

Proteins for FLOT2 Gene

  • Protein details for FLOT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14254-FLOT2_HUMAN
    Recommended name:
    Flotillin-2
    Protein Accession:
    Q14254

    Protein attributes for FLOT2 Gene

    Size:
    428 amino acids
    Molecular mass:
    47064 Da
    Quaternary structure:
    • Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2 (By similarity). Interacts with ECM29.
    SequenceCaution:
    • Sequence=AAA65729.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FLOT2 Gene

Post-translational modifications for FLOT2 Gene

  • ZDHHC5-catalyzed palmitoylation predominantly occurs at Cys-4. ZDHHC5-catalyzed palmitoylation may be required for the formation of higher-order complexes and for neurite outgrowth in cultured neural stem cells.
  • Ubiquitination at posLast=8181, isoforms=100, posLast=160160, posLast=169169, and posLast=370370
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FLOT2 (FLOT2)

No data available for DME Specific Peptides for FLOT2 Gene

Domains & Families for FLOT2 Gene

Gene Families for FLOT2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for FLOT2 Gene

Suggested Antigen Peptide Sequences for FLOT2 Gene

Graphical View of Domain Structure for InterPro Entry

Q14254

UniProtKB/Swiss-Prot:

FLOT2_HUMAN :
  • Belongs to the band 7/mec-2 family. Flotillin subfamily.
Family:
  • Belongs to the band 7/mec-2 family. Flotillin subfamily.
genes like me logo Genes that share domains with FLOT2: view

Function for FLOT2 Gene

Molecular function for FLOT2 Gene

GENATLAS Biochemistry:
flotillin 2,35kDa,resident integral membrane protein of caveolae from epithelial surface, involved in cell adhesion
UniProtKB/Swiss-Prot Function:
May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.

Phenotypes From GWAS Catalog for FLOT2 Gene

Gene Ontology (GO) - Molecular Function for FLOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IEA --
GO:0005515 protein binding IPI 17113085
GO:0035255 ionotropic glutamate receptor binding IEA --
GO:0046982 protein heterodimerization activity IMP 21696602
genes like me logo Genes that share ontologies with FLOT2: view
genes like me logo Genes that share phenotypes with FLOT2: view

Animal Models for FLOT2 Gene

MGI Knock Outs for FLOT2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FLOT2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FLOT2 Gene

Localization for FLOT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLOT2 Gene

Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Endosome. Membrane; Lipid-anchor. Note=Membrane-associated protein of caveolae.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FLOT2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endosome 5
mitochondrion 3
nucleus 3
cytosol 3
cytoskeleton 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FLOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001931 uropod IDA 21696602
GO:0002080 acrosomal membrane IEA --
GO:0005768 endosome IDA,IEA 20682791
GO:0005886 plasma membrane TAS,NAS --
GO:0005901 caveola IDA 24013648
genes like me logo Genes that share ontologies with FLOT2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FLOT2 Gene

Pathways & Interactions for FLOT2 Gene

genes like me logo Genes that share pathways with FLOT2: view

Pathways by source for FLOT2 Gene

1 Cell Signaling Technology pathway for FLOT2 Gene
1 KEGG pathway for FLOT2 Gene
1 Qiagen pathway for FLOT2 Gene

Gene Ontology (GO) - Biological Process for FLOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001765 membrane raft assembly IMP 25204797
GO:0007155 cell adhesion NAS,IEA --
GO:0008544 epidermis development TAS 8051082
GO:0010629 negative regulation of gene expression IMP 24612608
GO:0034114 NOT regulation of heterotypic cell-cell adhesion IMP 25204797
genes like me logo Genes that share ontologies with FLOT2: view

No data available for SIGNOR curated interactions for FLOT2 Gene

Drugs & Compounds for FLOT2 Gene

(3) Drugs for FLOT2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for FLOT2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FLOT2: view

Transcripts for FLOT2 Gene

Unigene Clusters for FLOT2 Gene

Flotillin 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FLOT2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FLOT2 Gene

No ASD Table

Relevant External Links for FLOT2 Gene

GeneLoc Exon Structure for
FLOT2
ECgene alternative splicing isoforms for
FLOT2

Expression for FLOT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FLOT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FLOT2 Gene

This gene is overexpressed in Whole Blood (x16.9).

Protein differential expression in normal tissues from HIPED for FLOT2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.5) and Nasal epithelium (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FLOT2 Gene



Protein tissue co-expression partners for FLOT2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FLOT2 Gene:

FLOT2

SOURCE GeneReport for Unigene cluster for FLOT2 Gene:

Hs.514038

mRNA Expression by UniProt/SwissProt for FLOT2 Gene:

Q14254-FLOT2_HUMAN
Tissue specificity: In skin, expressed in epidermis and epidermal appendages but not in dermis. Expressed in all layers of the epidermis except the basal layer. In hair follicles, expressed in the suprabasal layer but not the basal layer. Also expressed in melanoma and carcinoma cell lines, fibroblasts and foreskin melanocytes.

Evidence on tissue expression from TISSUES for FLOT2 Gene

  • Liver(4.4)
  • Pancreas(4.3)
  • Skin(4.3)
  • Nervous system(3.7)
  • Lung(2.9)
  • Blood(2.6)
  • Muscle(2.4)
  • Intestine(2.2)
  • Kidney(2.2)
  • Lymph node(2.2)
  • Eye(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with FLOT2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FLOT2 Gene

Orthologs for FLOT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FLOT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FLOT2 34 33
  • 99.61 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FLOT2 34 33
  • 92.52 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FLOT2 34 33
  • 92.33 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Flot2 16 34 33
  • 90.65 (n)
oppossum
(Monodelphis domestica)
Mammalia FLOT2 34
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Flot2 33
  • 88.79 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FLOT2 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves FLOT2 34
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FLOT2 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia flot2 33
  • 76.13 (n)
Str.3461 33
African clawed frog
(Xenopus laevis)
Amphibia flot2-prov 33
zebrafish
(Danio rerio)
Actinopterygii flot2a 34
  • 81 (a)
OneToMany
flot2b 33 34
  • 73.15 (n)
zgc64103 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9615 33
fruit fly
(Drosophila melanogaster)
Insecta Flo-2 35 33 34
  • 65.06 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003789 33
  • 64.75 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8302 34
  • 65 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2729 33
Species where no ortholog for FLOT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FLOT2 Gene

ENSEMBL:
Gene Tree for FLOT2 (if available)
TreeFam:
Gene Tree for FLOT2 (if available)

Paralogs for FLOT2 Gene

Paralogs for FLOT2 Gene

(1) SIMAP similar genes for FLOT2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with FLOT2: view

Variants for FLOT2 Gene

Sequence variations from dbSNP and Humsavar for FLOT2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000087723 -- 28,893,859(+) ACCCC(C/G/T)GTTAC intron-variant
rs1000197598 -- 28,897,409(+) CCGGG(A/G)GCCAG intron-variant, upstream-variant-2KB
rs1000237236 -- 28,887,297(+) CGAGA(A/G)GCTCC intron-variant
rs1000336539 -- 28,893,504(+) ACTCA(C/T)GGGCT intron-variant
rs1000708204 -- 28,893,744(+) AAAAT(A/C)AACTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FLOT2 Gene

Variant ID Type Subtype PubMed ID
nsv457719 CNV loss 19166990
nsv574662 CNV loss 21841781

Variation tolerance for FLOT2 Gene

Residual Variation Intolerance Score: 43.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.51; 43.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FLOT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FLOT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLOT2 Gene

Disorders for FLOT2 Gene

Relevant External Links for FLOT2

Human Genome Epidemiology (HuGE) Navigator
FLOT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FLOT2

No disorders were found for FLOT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FLOT2 Gene

Publications for FLOT2 Gene

  1. Cloning and characterization of a novel epidermal cell surface antigen (ESA). (PMID: 8051082) Schroeder WT … Duvic M (The Journal of biological chemistry 1994) 3 4 22 60
  2. The human gene for an epidermal surface antigen (M17S1) is located at 17q11-12. (PMID: 1769667) Schroeder WT … Duvic M (Genomics 1991) 2 3 22 60
  3. DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells. (PMID: 22081607) Li Y … Hofmann SL (The Journal of biological chemistry 2012) 3 4 60
  4. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PMID: 20682791) Gorbea C … Rechsteiner M (The Journal of biological chemistry 2010) 3 4 60
  5. Basolateral internalization of GPI-anchored proteins occurs via a clathrin-independent flotillin-dependent pathway in polarized hepatic cells. (PMID: 19605558) Aït-Slimane T … Maurice M (Molecular biology of the cell 2009) 3 22 60

Products for FLOT2 Gene

Sources for FLOT2 Gene

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