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Aliases for FLOT2 Gene

Aliases for FLOT2 Gene

  • Flotillin 2 2 3 5
  • Membrane Component Chromosome 17 Surface Marker 1 3 4
  • Flotillin 2 (Epidermal Surface Antigen 1) 2 3
  • Epidermal Surface Antigen 3 4
  • M17S1 3 4
  • ESA1 3 4
  • ESA 3 4
  • Membrane Component, Chromosome 17, Surface Marker 1 (35kD Protein Identified By Monoclonal Antibody ECS-1) 3
  • Surface Marker 1 (35kD Protein Identified By Monoclonal Antibody ECS-1) 2
  • Membrane Component 2
  • Chromosome 17 2
  • ECS-1 3
  • ECS1 3

External Ids for FLOT2 Gene

Previous HGNC Symbols for FLOT2 Gene

  • M17S1

Previous GeneCards Identifiers for FLOT2 Gene

  • GC17M027051
  • GC17M029105
  • GC17M027351
  • GC17M024230
  • GC17M027206
  • GC17M023414

Summaries for FLOT2 Gene

Entrez Gene Summary for FLOT2 Gene

  • Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling. [provided by RefSeq, Jul 2008]

GeneCards Summary for FLOT2 Gene

FLOT2 (Flotillin 2) is a Protein Coding gene. Diseases associated with FLOT2 include toxic megacolon. Among its related pathways are Transmission across Chemical Synapses and Translation Insulin regulation of translation. GO annotations related to this gene include protease binding and ionotropic glutamate receptor binding. An important paralog of this gene is FLOT1.

UniProtKB/Swiss-Prot for FLOT2 Gene

  • May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.

Gene Wiki entry for FLOT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLOT2 Gene

Genomics for FLOT2 Gene

Regulatory Elements for FLOT2 Gene

Promoters for FLOT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FLOT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FLOT2 Gene

Chromosome:
17
Start:
28,879,335 bp from pter
End:
28,897,697 bp from pter
Size:
18,363 bases
Orientation:
Minus strand

Genomic View for FLOT2 Gene

Genes around FLOT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FLOT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FLOT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FLOT2 Gene

Proteins for FLOT2 Gene

  • Protein details for FLOT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14254-FLOT2_HUMAN
    Recommended name:
    Flotillin-2
    Protein Accession:
    Q14254

    Protein attributes for FLOT2 Gene

    Size:
    428 amino acids
    Molecular mass:
    47064 Da
    Quaternary structure:
    • Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2 (By similarity). Interacts with ECM29.
    SequenceCaution:
    • Sequence=AAA65729.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FLOT2 Gene

Proteomics data for FLOT2 Gene at MOPED

Post-translational modifications for FLOT2 Gene

  • ZDHHC5-catalyzed palmitoylation predominantly occurs at Cys-4. ZDHHC5-catalyzed palmitoylation may be required for the formation of higher-order complexes and for neurite outgrowth in cultured neural stem cells.
  • Ubiquitination at Lys 81, Lys 100, Lys 160, Lys 169, and Lys 370
  • Modification sites at PhosphoSitePlus

Other Protein References for FLOT2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FLOT2 (FLOT2)

No data available for DME Specific Peptides for FLOT2 Gene

Domains & Families for FLOT2 Gene

Gene Families for FLOT2 Gene

Protein Domains for FLOT2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FLOT2 Gene

Graphical View of Domain Structure for InterPro Entry

Q14254

UniProtKB/Swiss-Prot:

FLOT2_HUMAN :
  • Belongs to the band 7/mec-2 family. Flotillin subfamily.
Family:
  • Belongs to the band 7/mec-2 family. Flotillin subfamily.
genes like me logo Genes that share domains with FLOT2: view

Function for FLOT2 Gene

Molecular function for FLOT2 Gene

GENATLAS Biochemistry:
flotillin 2,35kDa,resident integral membrane protein of caveolae from epithelial surface, involved in cell adhesion
UniProtKB/Swiss-Prot Function:
May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.
genes like me logo Genes that share phenotypes with FLOT2: view

Animal Models for FLOT2 Gene

MGI Knock Outs for FLOT2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FLOT2 Gene

Localization for FLOT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLOT2 Gene

Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Endosome. Membrane; Lipid-anchor. Note=Membrane-associated protein of caveolae.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FLOT2 Gene COMPARTMENTS Subcellular localization image for FLOT2 gene
Compartment Confidence
endosome 5
extracellular 5
plasma membrane 5
cytosol 3
mitochondrion 3
nucleus 3
cytoskeleton 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FLOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002080 acrosomal membrane IEA --
GO:0005768 endosome IDA 20682791
GO:0005913 cell-cell adherens junction IDA 24046456
GO:0016020 membrane IEA,IDA 19946888
GO:0016323 basolateral plasma membrane IDA 23983584
genes like me logo Genes that share ontologies with FLOT2: view

Pathways & Interactions for FLOT2 Gene

genes like me logo Genes that share pathways with FLOT2: view

Pathways by source for FLOT2 Gene

1 BioSystems pathway for FLOT2 Gene
2 Reactome pathways for FLOT2 Gene
1 KEGG pathway for FLOT2 Gene
1 Qiagen pathway for FLOT2 Gene

Gene Ontology (GO) - Biological Process for FLOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 synaptic transmission TAS --
GO:0008544 epidermis development TAS 8051082
genes like me logo Genes that share ontologies with FLOT2: view

No data available for SIGNOR curated interactions for FLOT2 Gene

Drugs & Compounds for FLOT2 Gene

(3) Drugs for FLOT2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for FLOT2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FLOT2: view

Transcripts for FLOT2 Gene

Unigene Clusters for FLOT2 Gene

Flotillin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FLOT2 Gene

No ASD Table

Relevant External Links for FLOT2 Gene

GeneLoc Exon Structure for
FLOT2
ECgene alternative splicing isoforms for
FLOT2

Expression for FLOT2 Gene

mRNA expression in normal human tissues for FLOT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FLOT2 Gene

This gene is overexpressed in Whole Blood (x16.9).

Protein differential expression in normal tissues from HIPED for FLOT2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.5) and Nasal epithelium (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FLOT2 Gene



SOURCE GeneReport for Unigene cluster for FLOT2 Gene Hs.514038

mRNA Expression by UniProt/SwissProt for FLOT2 Gene

Q14254-FLOT2_HUMAN
Tissue specificity: In skin, expressed in epidermis and epidermal appendages but not in dermis. Expressed in all layers of the epidermis except the basal layer. In hair follicles, expressed in the suprabasal layer but not the basal layer. Also expressed in melanoma and carcinoma cell lines, fibroblasts and foreskin melanocytes.
genes like me logo Genes that share expression patterns with FLOT2: view

Protein tissue co-expression partners for FLOT2 Gene

Primer Products

In Situ Assay Products

Orthologs for FLOT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FLOT2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FLOT2 35
  • 92.52 (n)
  • 98.6 (a)
FLOT2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FLOT2 35
  • 92.33 (n)
  • 99.3 (a)
FLOT2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Flot2 35
  • 90.65 (n)
  • 99.07 (a)
Flot2 16
Flot2 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FLOT2 35
  • 99.61 (n)
  • 100 (a)
FLOT2 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Flot2 35
  • 88.79 (n)
  • 96.96 (a)
oppossum
(Monodelphis domestica)
Mammalia FLOT2 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FLOT2 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves FLOT2 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FLOT2 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia flot2 35
  • 76.13 (n)
  • 86.15 (a)
Str.3461 35
African clawed frog
(Xenopus laevis)
Amphibia flot2-prov 35
zebrafish
(Danio rerio)
Actinopterygii flot2b 35
  • 73.15 (n)
  • 81.03 (a)
zgc64103 35
flot2a 36
  • 81 (a)
OneToMany
flot2b 36
  • 81 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9615 35
fruit fly
(Drosophila melanogaster)
Insecta Flo-2 37
  • 65 (a)
Flo-2 35
  • 65.06 (n)
  • 66.35 (a)
Flo-2 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003789 35
  • 64.75 (n)
  • 65.66 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2729 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8302 36
  • 65 (a)
OneToOne
Species with no ortholog for FLOT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FLOT2 Gene

ENSEMBL:
Gene Tree for FLOT2 (if available)
TreeFam:
Gene Tree for FLOT2 (if available)

Paralogs for FLOT2 Gene

Paralogs for FLOT2 Gene

(1) SIMAP similar genes for FLOT2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with FLOT2: view

Variants for FLOT2 Gene

Sequence variations from dbSNP and Humsavar for FLOT2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs3736238 - 28,881,308(+) GACTG(C/T)CGCTT reference, missense
rs9617 -- 28,879,510(-) CAAGC(A/C/G)TCTTG utr-variant-3-prime
rs10205 -- 28,880,102(-) GTCCT(C/T)TCTCC utr-variant-3-prime
rs14117 -- 28,879,611(-) TGCCA(A/T)CTTTC utr-variant-3-prime
rs1060244 -- 28,880,553(-) CTCCT(A/G)CAGGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FLOT2 Gene

Variant ID Type Subtype PubMed ID
nsv457719 CNV Loss 19166990

Variation tolerance for FLOT2 Gene

Residual Variation Intolerance Score: 43.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.51; 43.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FLOT2 Gene

HapMap Linkage Disequilibrium report
FLOT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLOT2 Gene

Disorders for FLOT2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FLOT2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
toxic megacolon
  • megacolon, toxic
- elite association - COSMIC cancer census association via MalaCards
Search FLOT2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FLOT2

Human Genome Epidemiology (HuGE) Navigator
FLOT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FLOT2
genes like me logo Genes that share disorders with FLOT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FLOT2 Gene

Publications for FLOT2 Gene

  1. Cloning and characterization of a novel epidermal cell surface antigen (ESA). (PMID: 8051082) Schroeder W.T. … Duvic M. (J. Biol. Chem. 1994) 3 4 23 67
  2. The human gene for an epidermal surface antigen (M17S1) is located at 17q11-12. (PMID: 1769667) Schroeder W.T. … Duvic M. (Genomics 1991) 2 3 23
  3. Hetero-oligomerization of reggie-1/flotillin-2 and reggie-2/flotillin-1 is required for their endocytosis. (PMID: 19318123) Babuke T. … Tikkanen R. (Cell. Signal. 2009) 3 23
  4. Paradoxical condensation of copper with elevated beta-amyloid in lipid rafts under cellular copper deficiency conditions: implications for Alzheimer disease. (PMID: 19542222) Hung Y.H. … Bush A.I. (J. Biol. Chem. 2009) 3 23
  5. Basolateral internalization of GPI-anchored proteins occurs via a clathrin-independent flotillin-dependent pathway in polarized hepatic cells. (PMID: 19605558) AA^t-Slimane T. … Maurice M. (Mol. Biol. Cell 2009) 3 23

Products for FLOT2 Gene

Sources for FLOT2 Gene

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