Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FLOT1 Gene

Aliases for FLOT1 Gene

  • Flotillin 1 2 3 5

External Ids for FLOT1 Gene

Previous GeneCards Identifiers for FLOT1 Gene

  • GC06M030751
  • GC06M030466
  • GC06M030801
  • GC06M030803
  • GC06M030695

Summaries for FLOT1 Gene

Entrez Gene Summary for FLOT1 Gene

  • This gene encodes an protein that localizes to the caveolae, which are small domains on the inner cell membranes. This protein plays a role in vesicle trafficking and cell morphology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for FLOT1 Gene

FLOT1 (Flotillin 1) is a Protein Coding gene. Diseases associated with FLOT1 include mycobacterium marinum. Among its related pathways are Transmission across Chemical Synapses and Translation Insulin regulation of translation. GO annotations related to this gene include protease binding and ionotropic glutamate receptor binding. An important paralog of this gene is FLOT2.

UniProtKB/Swiss-Prot for FLOT1 Gene

  • May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.

Gene Wiki entry for FLOT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLOT1 Gene

Genomics for FLOT1 Gene

Regulatory Elements for FLOT1 Gene

Promoters for FLOT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FLOT1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the FLOT1 gene promoter:

Genomic Location for FLOT1 Gene

Chromosome:
6
Start:
30,727,709 bp from pter
End:
30,742,733 bp from pter
Size:
15,025 bases
Orientation:
Minus strand

Genomic View for FLOT1 Gene

Genes around FLOT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FLOT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FLOT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for FLOT1 Gene

  • Protein details for FLOT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75955-FLOT1_HUMAN
    Recommended name:
    Flotillin-1
    Protein Accession:
    O75955
    Secondary Accessions:
    • B4DVY7
    • Q969J8
    • Q9UHW1
    • Q9UNV8

    Protein attributes for FLOT1 Gene

    Size:
    427 amino acids
    Molecular mass:
    47355 Da
    Quaternary structure:
    • Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2 (By similarity). Interacts with ECM29.

    Alternative splice isoforms for FLOT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FLOT1 Gene

Proteomics data for FLOT1 Gene at MOPED

Post-translational modifications for FLOT1 Gene

  • Ubiquitination at Lys 78, Lys 211, and Lys 422
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FLOT1 (FLOT1)

No data available for DME Specific Peptides for FLOT1 Gene

Domains & Families for FLOT1 Gene

Gene Families for FLOT1 Gene

Protein Domains for FLOT1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FLOT1 Gene

Graphical View of Domain Structure for InterPro Entry

O75955

UniProtKB/Swiss-Prot:

FLOT1_HUMAN :
  • Belongs to the band 7/mec-2 family. Flotillin subfamily.
Family:
  • Belongs to the band 7/mec-2 family. Flotillin subfamily.
genes like me logo Genes that share domains with FLOT1: view

Function for FLOT1 Gene

Molecular function for FLOT1 Gene

UniProtKB/Swiss-Prot Function:
May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
genes like me logo Genes that share phenotypes with FLOT1: view

Animal Models for FLOT1 Gene

MGI Knock Outs for FLOT1:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FLOT1 Gene

Localization for FLOT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLOT1 Gene

Cell membrane; Peripheral membrane protein. Endosome. Membrane, caveola; Peripheral membrane protein. Melanosome. Membrane raft. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Membrane-associated protein of caveola (By similarity). {ECO:0000250 UniProtKB:O08917, ECO:0000269 PubMed:17081065}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FLOT1 Gene COMPARTMENTS Subcellular localization image for FLOT1 gene
Compartment Confidence
cytosol 2
cytoskeleton 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FLOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001931 uropod IDA 21696602
GO:0005768 endosome IDA 20682791
GO:0005769 early endosome IDA 21399631
GO:0005886 plasma membrane IEA,IMP 21696602
GO:0005913 cell-cell adherens junction IDA 24046456
genes like me logo Genes that share ontologies with FLOT1: view

Pathways & Interactions for FLOT1 Gene

genes like me logo Genes that share pathways with FLOT1: view

Pathways by source for FLOT1 Gene

1 BioSystems pathway for FLOT1 Gene
2 Reactome pathways for FLOT1 Gene
1 KEGG pathway for FLOT1 Gene
1 Qiagen pathway for FLOT1 Gene

Gene Ontology (GO) - Biological Process for FLOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002090 regulation of receptor internalization IEA,IMP 21399631
GO:0032728 positive regulation of interferon-beta production IMP 25204797
GO:0034141 positive regulation of toll-like receptor 3 signaling pathway IMP 25204797
GO:0034143 NOT regulation of toll-like receptor 4 signaling pathway IMP 25204797
GO:0034976 response to endoplasmic reticulum stress IMP 25204797
genes like me logo Genes that share ontologies with FLOT1: view

No data available for SIGNOR curated interactions for FLOT1 Gene

Drugs & Compounds for FLOT1 Gene

(3) Drugs for FLOT1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for FLOT1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FLOT1: view

Transcripts for FLOT1 Gene

Unigene Clusters for FLOT1 Gene

Flotillin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FLOT1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c
SP1: - - - - -
SP2: - - - - - - - - -
SP3:
SP4: - -
SP5: - -
SP6:
SP7: - - - - - - - -
SP8:

Relevant External Links for FLOT1 Gene

GeneLoc Exon Structure for
FLOT1
ECgene alternative splicing isoforms for
FLOT1

Expression for FLOT1 Gene

mRNA expression in normal human tissues for FLOT1 Gene

mRNA differential expression in normal tissues according to GTEx for FLOT1 Gene

This gene is overexpressed in Whole Blood (x7.0).

Protein differential expression in normal tissues from HIPED for FLOT1 Gene

This gene is overexpressed in Nasal epithelium (12.6) and Peripheral blood mononuclear cells (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FLOT1 Gene



SOURCE GeneReport for Unigene cluster for FLOT1 Gene Hs.179986

genes like me logo Genes that share expression patterns with FLOT1: view

Protein tissue co-expression partners for FLOT1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FLOT1 Gene

Orthologs for FLOT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FLOT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FLOT1 35
  • 93.05 (n)
  • 99.06 (a)
FLOT1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FLOT1 35
  • 92.74 (n)
  • 99.06 (a)
FLOT1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Flot1 35
  • 89.93 (n)
  • 98.36 (a)
Flot1 16
Flot1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FLOT1 35
  • 99.84 (n)
  • 99.77 (a)
FLOT1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Flot1 35
  • 90.16 (n)
  • 98.13 (a)
oppossum
(Monodelphis domestica)
Mammalia FLOT1 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FLOT1 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia flot1 35
  • 72.2 (n)
  • 81.28 (a)
Str.7164 35
zebrafish
(Danio rerio)
Actinopterygii flot1a 35
  • 74.8 (n)
  • 80.62 (a)
wufb53d05 35
flot1a 36
  • 77 (a)
OneToMany
flot1b 36
  • 79 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Flo 37
  • 65 (a)
Flo-1 35
  • 66.35 (n)
  • 65 (a)
Flo-1 36
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007494 35
  • 66.43 (n)
  • 67.22 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4127 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 62 (a)
OneToOne
Species with no ortholog for FLOT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FLOT1 Gene

ENSEMBL:
Gene Tree for FLOT1 (if available)
TreeFam:
Gene Tree for FLOT1 (if available)

Paralogs for FLOT1 Gene

Paralogs for FLOT1 Gene

genes like me logo Genes that share paralogs with FLOT1: view

Variants for FLOT1 Gene

Sequence variations from dbSNP and Humsavar for FLOT1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs3180825 - 30,741,669(-) CAAGA(A/G)TGAAA intron-variant, reference, missense
rs15297 -- 30,741,587(+) GGACT(C/G/T)TGGGG intron-variant
rs1136719 -- 30,728,143(-) CAGGT(A/C/G)AATCA reference, synonymous-codon
rs1059597 -- 30,727,892(-) GCCTT(C/T)TGATG utr-variant-3-prime
rs1059612 -- 30,741,178(-) CTAGG(A/G)GCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FLOT1 Gene

Variant ID Type Subtype PubMed ID
esv2731791 CNV Deletion 23290073
esv2670269 CNV Deletion 23128226
nsv830626 CNV Loss 17160897
dgv1917e1 CNV Complex 17122850
nsv884100 CNV Gain 21882294
nsv884101 CNV Gain 21882294
nsv884102 CNV Gain 21882294

Variation tolerance for FLOT1 Gene

Residual Variation Intolerance Score: 29.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.83; 17.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FLOT1 Gene

HapMap Linkage Disequilibrium report
FLOT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLOT1 Gene

Disorders for FLOT1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FLOT1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
mycobacterium marinum
  • fish tank granuloma
- elite association - COSMIC cancer census association via MalaCards
Search FLOT1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FLOT1

Genetic Association Database (GAD)
FLOT1
Human Genome Epidemiology (HuGE) Navigator
FLOT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FLOT1
genes like me logo Genes that share disorders with FLOT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FLOT1 Gene

Publications for FLOT1 Gene

  1. Flotillin-1: gene structure: cDNA cloning from human lung and the identification of alternative polyadenylation signals. (PMID: 11167132) Edgar A.J. … Polak J.M. (Int. J. Biochem. Cell Biol. 2001) 3 4 23 67
  2. The Mycobacterium bovis bacille Calmette-Guerin phagosome proteome. (PMID: 19815536) Lee B.Y. … Horwitz M.A. (Mol. Cell Proteomics 2010) 3 23
  3. Flotillin-1 stabilizes caveolin-1 in intestinal epithelial cells. (PMID: 19121286) Vassilieva E.V. … Nusrat A. (Biochem. Biophys. Res. Commun. 2009) 3 23
  4. Endocytosis of flotillin-1 and flotillin-2 is regulated by Fyn kinase. (PMID: 19258392) Riento K. … Nichols B.J. (J. Cell. Sci. 2009) 3 23
  5. Hetero-oligomerization of reggie-1/flotillin-2 and reggie-2/flotillin-1 is required for their endocytosis. (PMID: 19318123) Babuke T. … Tikkanen R. (Cell. Signal. 2009) 3 23

Products for FLOT1 Gene

Sources for FLOT1 Gene

Back to Top

Content