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Aliases for FLOT1 Gene

Aliases for FLOT1 Gene

  • Flotillin 1 2 3 5
  • Integral Membrane Component Of Caveolae 3
  • Flotillin-1 3

External Ids for FLOT1 Gene

Previous GeneCards Identifiers for FLOT1 Gene

  • GC06M030751
  • GC06M030466
  • GC06M030801
  • GC06M030803
  • GC06M030695

Summaries for FLOT1 Gene

Entrez Gene Summary for FLOT1 Gene

  • This gene encodes an protein that localizes to the caveolae, which are small domains on the inner cell membranes. This protein plays a role in vesicle trafficking and cell morphology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for FLOT1 Gene

FLOT1 (Flotillin 1) is a Protein Coding gene. Diseases associated with FLOT1 include Mycobacterium Marinum. Among its related pathways are Transmission across Chemical Synapses and Protein-protein interactions at synapses. GO annotations related to this gene include protease binding and ionotropic glutamate receptor binding. An important paralog of this gene is FLOT2.

UniProtKB/Swiss-Prot for FLOT1 Gene

  • May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.

Gene Wiki entry for FLOT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLOT1 Gene

Genomics for FLOT1 Gene

Regulatory Elements for FLOT1 Gene

Enhancers for FLOT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F030798 1.4 Ensembl ENCODE 22.8 -57.5 -57468 4.0 HDGF PKNOX1 ARNT MLX CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 DDR1 IER3 FLOT1 VARS2 LINC00243 DDR1-AS1 MIR4640 GTF2H4 DPCR1 HCG21
GH06F030776 1.9 FANTOM5 Ensembl ENCODE 14.4 -40.6 -40568 13.8 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 IER3 PPP1R10 PAIP1P1 DHX16 LY6G5B GTF2H4 ABCF1 DDX39B VARS2 HCG18
GH06F030757 1.9 FANTOM5 Ensembl ENCODE 14 -21.5 -21520 14.1 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 IER3 VARS2 DDR1 C6orf136 PPP1R18 FLOT1 HCG18 LINC00243 PRR3 TUBB
GH06F030816 1.8 FANTOM5 Ensembl ENCODE 13.9 -77.3 -77268 6.8 HDGF PKNOX1 ARNT MLX ARID4B SLC30A9 ZNF143 FOS KLF13 SP5 IER3 DDR1 HCG18 PRR3 RPP21 PPP1R10 HLA-E PPP1R18 FLOT1 LINC00243
GH06F030792 1.4 FANTOM5 Ensembl ENCODE 13.5 -51.3 -51268 2.4 ELF3 TBP TBL1XR1 ZBTB40 RARA SMARCA5 JUNB ELF1 TBX21 SP1 IER3 VARS2 FLOT1 LINC00243 DDR1 DDR1-AS1 MIR4640 GTF2H4 HCG20 DPCR1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FLOT1 on UCSC Golden Path with GeneCards custom track

Promoters for FLOT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000487690 -467 3601 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC MEF2D

Transcription factor binding sites by QIAGEN in the FLOT1 gene promoter:

Genomic Location for FLOT1 Gene

Chromosome:
6
Start:
30,727,709 bp from pter
End:
30,742,733 bp from pter
Size:
15,025 bases
Orientation:
Minus strand

Genomic View for FLOT1 Gene

Genes around FLOT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FLOT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FLOT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for FLOT1 Gene

  • Protein details for FLOT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75955-FLOT1_HUMAN
    Recommended name:
    Flotillin-1
    Protein Accession:
    O75955
    Secondary Accessions:
    • B4DVY7
    • Q969J8
    • Q9UHW1
    • Q9UNV8

    Protein attributes for FLOT1 Gene

    Size:
    427 amino acids
    Molecular mass:
    47355 Da
    Quaternary structure:
    • Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2 (By similarity). Interacts with ECM29.

    Alternative splice isoforms for FLOT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FLOT1 Gene

Post-translational modifications for FLOT1 Gene

  • Ubiquitination at Lys 78, Lys 211, and Lys 422
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FLOT1 (FLOT1)

No data available for DME Specific Peptides for FLOT1 Gene

Domains & Families for FLOT1 Gene

Gene Families for FLOT1 Gene

Protein Domains for FLOT1 Gene

Suggested Antigen Peptide Sequences for FLOT1 Gene

Graphical View of Domain Structure for InterPro Entry

O75955

UniProtKB/Swiss-Prot:

FLOT1_HUMAN :
  • Belongs to the band 7/mec-2 family. Flotillin subfamily.
Family:
  • Belongs to the band 7/mec-2 family. Flotillin subfamily.
genes like me logo Genes that share domains with FLOT1: view

Function for FLOT1 Gene

Molecular function for FLOT1 Gene

UniProtKB/Swiss-Prot Function:
May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.

Gene Ontology (GO) - Molecular Function for FLOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IEA,IPI 24612608
GO:0005515 protein binding IPI 15469992
GO:0035255 ionotropic glutamate receptor binding IEA --
GO:0046982 protein heterodimerization activity IMP 21696602
genes like me logo Genes that share ontologies with FLOT1: view
genes like me logo Genes that share phenotypes with FLOT1: view

Animal Models for FLOT1 Gene

MGI Knock Outs for FLOT1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FLOT1 Gene

Localization for FLOT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLOT1 Gene

Cell membrane; Peripheral membrane protein. Endosome. Membrane, caveola; Peripheral membrane protein. Melanosome. Membrane raft. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Membrane-associated protein of caveola (By similarity). {ECO:0000250 UniProtKB:O08917, ECO:0000269 PubMed:17081065}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FLOT1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
lysosome 5
endosome 5
cytosol 2
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FLOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001931 uropod IDA 21696602
GO:0005765 lysosomal membrane IDA 17897319
GO:0005768 endosome IEA,IDA 20682791
GO:0005769 early endosome IDA 21399631
GO:0005815 microtubule organizing center IDA 18000879
genes like me logo Genes that share ontologies with FLOT1: view

Pathways & Interactions for FLOT1 Gene

genes like me logo Genes that share pathways with FLOT1: view

Pathways by source for FLOT1 Gene

1 Cell Signaling Technology pathway for FLOT1 Gene
1 BioSystems pathway for FLOT1 Gene
1 KEGG pathway for FLOT1 Gene
1 Qiagen pathway for FLOT1 Gene

Gene Ontology (GO) - Biological Process for FLOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001765 membrane raft assembly IMP 25204797
GO:0001819 positive regulation of cytokine production IMP 25204797
GO:0001934 positive regulation of protein phosphorylation IMP 25204797
GO:0002090 regulation of receptor internalization IEA,IMP 21399631
GO:0007409 axonogenesis IEA --
genes like me logo Genes that share ontologies with FLOT1: view

No data available for SIGNOR curated interactions for FLOT1 Gene

Drugs & Compounds for FLOT1 Gene

(4) Drugs for FLOT1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for FLOT1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FLOT1: view

Transcripts for FLOT1 Gene

Unigene Clusters for FLOT1 Gene

Flotillin 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FLOT1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c
SP1: - - - - -
SP2: - - - - - - - - -
SP3:
SP4: - -
SP5: - -
SP6:
SP7: - - - - - - - -
SP8:

Relevant External Links for FLOT1 Gene

GeneLoc Exon Structure for
FLOT1
ECgene alternative splicing isoforms for
FLOT1

Expression for FLOT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FLOT1 Gene

mRNA differential expression in normal tissues according to GTEx for FLOT1 Gene

This gene is overexpressed in Whole Blood (x7.0).

Protein differential expression in normal tissues from HIPED for FLOT1 Gene

This gene is overexpressed in Nasal epithelium (12.6) and Peripheral blood mononuclear cells (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FLOT1 Gene



Protein tissue co-expression partners for FLOT1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FLOT1 Gene:

FLOT1

SOURCE GeneReport for Unigene cluster for FLOT1 Gene:

Hs.179986
genes like me logo Genes that share expression patterns with FLOT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FLOT1 Gene

Orthologs for FLOT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FLOT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FLOT1 34 35
  • 99.84 (n)
cow
(Bos Taurus)
Mammalia FLOT1 34 35
  • 93.05 (n)
oppossum
(Monodelphis domestica)
Mammalia FLOT1 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FLOT1 34 35
  • 92.74 (n)
rat
(Rattus norvegicus)
Mammalia Flot1 34
  • 90.16 (n)
mouse
(Mus musculus)
Mammalia Flot1 34 16 35
  • 89.93 (n)
lizard
(Anolis carolinensis)
Reptilia FLOT1 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia flot1 34
  • 72.2 (n)
Str.7164 34
zebrafish
(Danio rerio)
Actinopterygii flot1b 35
  • 79 (a)
OneToMany
flot1a 34 35
  • 74.8 (n)
wufb53d05 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007494 34
  • 66.43 (n)
fruit fly
(Drosophila melanogaster)
Insecta Flo-1 34 35
  • 66.35 (n)
Flo 36
  • 65 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 62 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4127 34
Species where no ortholog for FLOT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FLOT1 Gene

ENSEMBL:
Gene Tree for FLOT1 (if available)
TreeFam:
Gene Tree for FLOT1 (if available)

Paralogs for FLOT1 Gene

Paralogs for FLOT1 Gene

genes like me logo Genes that share paralogs with FLOT1: view

Variants for FLOT1 Gene

Sequence variations from dbSNP and Humsavar for FLOT1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1049942 -- 30,743,290(-) AGGTA(A/G)AGGGT nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1049943 -- 30,743,249(-) GTCGA(C/G)ATCGC nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs10537729 -- 30,735,597(+) TGCAC(-/CTGCAC)TCCAG intron-variant
rs1059597 -- 30,727,892(-) GCCTT(C/T)TGATG utr-variant-3-prime
rs1059612 -- 30,741,178(-) CTAGG(A/G)GCAGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FLOT1 Gene

Variant ID Type Subtype PubMed ID
nsv830626 CNV loss 17160897
nsv601481 CNV loss 21841781
nsv601264 CNV loss 21841781
nsv1144137 CNV deletion 24896259
nsv1122126 CNV deletion 24896259
nsv1074389 CNV deletion 25765185
esv3576135 CNV gain 25503493
esv3411275 CNV duplication 20981092
esv2759413 CNV loss 17122850
esv2731791 CNV deletion 23290073
esv2670269 CNV deletion 23128226

Variation tolerance for FLOT1 Gene

Residual Variation Intolerance Score: 29.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.83; 17.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FLOT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FLOT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLOT1 Gene

Disorders for FLOT1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FLOT1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
mycobacterium marinum
  • fish tank granuloma
- elite association - COSMIC cancer census association via MalaCards
Search FLOT1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FLOT1

Genetic Association Database (GAD)
FLOT1
Human Genome Epidemiology (HuGE) Navigator
FLOT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FLOT1
genes like me logo Genes that share disorders with FLOT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FLOT1 Gene

Publications for FLOT1 Gene

  1. Flotillin-1: gene structure: cDNA cloning from human lung and the identification of alternative polyadenylation signals. (PMID: 11167132) Edgar A.J. … Polak J.M. (Int. J. Biochem. Cell Biol. 2001) 3 4 22 64
  2. Syntenin regulates TGF-beta1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-beta type I receptor internalization. (PMID: 25893292) Hwangbo C. … Lee J.H. (Oncogene 2015) 3 4 64
  3. The Mycobacterium bovis bacille Calmette-Guerin phagosome proteome. (PMID: 19815536) Lee B.Y. … Horwitz M.A. (Mol. Cell Proteomics 2010) 3 22 64
  4. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PMID: 20682791) Gorbea C. … Rechsteiner M. (J. Biol. Chem. 2010) 3 4 64
  5. Hetero-oligomerization of reggie-1/flotillin-2 and reggie-2/flotillin-1 is required for their endocytosis. (PMID: 19318123) Babuke T. … Tikkanen R. (Cell. Signal. 2009) 3 22 64

Products for FLOT1 Gene

Sources for FLOT1 Gene

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