Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FLOT1 Gene

Aliases for FLOT1 Gene

  • Flotillin 1 2 3
  • Integral Membrane Component Of Caveolae 3
  • Flotillin-1 3

External Ids for FLOT1 Gene

Summaries for FLOT1 Gene

Entrez Gene Summary for FLOT1 Gene

  • Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. FLOT1 encodes a caveolae-associated, integral membrane protein. The function of flotillin 1 has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for FLOT1 Gene

FLOT1 (Flotillin 1) is a Protein Coding gene. Diseases associated with FLOT1 include mycobacterium marinum and bardet-biedl syndrome. Among its related pathways are Cytoskeletal Signaling and Insulin Signaling. GO annotations related to this gene include ionotropic glutamate receptor binding. An important paralog of this gene is FLOT2.

UniProtKB/Swiss-Prot for FLOT1 Gene

  • May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles

Gene Wiki entry for FLOT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLOT1 Gene

Genomics for FLOT1 Gene

Genomic Location for FLOT1 Gene

Start:
30,727,709 bp from pter
End:
30,742,910 bp from pter
Size:
15,202 bases
Orientation:
Minus strand

Genomic View for FLOT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FLOT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for FLOT1 Gene

Transcription factor binding sites by QIAGEN in the FLOT1 gene promoter:

Proteins for FLOT1 Gene

  • Protein details for FLOT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75955-FLOT1_HUMAN
    Recommended name:
    Flotillin-1
    Protein Accession:
    O75955
    Secondary Accessions:
    • B4DVY7
    • Q969J8
    • Q9UHW1
    • Q9UNV8

    Protein attributes for FLOT1 Gene

    Size:
    427 amino acids
    Molecular mass:
    47355 Da
    Quaternary structure:
    • Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2 (By similarity). Interacts with ECM29.

    Alternative splice isoforms for FLOT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FLOT1 Gene

Proteomics data for FLOT1 Gene at MOPED

Post-translational modifications for FLOT1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys78, Lys211, and Lys422

Other Protein References for FLOT1 Gene

No data available for DME Specific Peptides for FLOT1 Gene

Domains for FLOT1 Gene

Protein Domains for FLOT1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

FLOT1_HUMAN
Family:
  • Belongs to the band 7/mec-2 family. Flotillin subfamily.:
    • O75955
genes like me logo Genes that share domains with FLOT1: view

No data available for Gene Families for FLOT1 Gene

Function for FLOT1 Gene

Molecular function for FLOT1 Gene

UniProtKB/Swiss-Prot Function: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles

Gene Ontology (GO) - Molecular Function for FLOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 24612608
GO:0005515 protein binding IPI 15469992
GO:0035255 ionotropic glutamate receptor binding IEA --
genes like me logo Genes that share ontologies with FLOT1: view

Phenotypes for FLOT1 Gene

genes like me logo Genes that share phenotypes with FLOT1: view

Animal Models for FLOT1 Gene

MGI Knock Outs for FLOT1:

miRNA for FLOT1 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FLOT1 Gene

Localization for FLOT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLOT1 Gene

Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Melanosome. Endosome. Note=Membrane-associated protein of caveolae. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FLOT1 Gene COMPARTMENTS Subcellular localization image for FLOT1 gene
Compartment Confidence
endosome 5
plasma membrane 5
cytoskeleton 4
cytosol 2
vacuole 2
extracellular 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FLOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
GO:0005768 endosome IDA 20682791
GO:0005815 microtubule organizing center IDA 18000879
GO:0005886 plasma membrane --
GO:0005901 caveola TAS 9153235
genes like me logo Genes that share ontologies with FLOT1: view

Pathways for FLOT1 Gene

genes like me logo Genes that share pathways with FLOT1: view

Pathways by source for FLOT1 Gene

1 Qiagen pathway for FLOT1 Gene
1 Cell Signaling Technology pathway for FLOT1 Gene
1 BioSystems pathway for FLOT1 Gene
1 KEGG pathway for FLOT1 Gene

Gene Ontology (GO) - Biological Process for FLOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007409 axonogenesis IEA --
GO:0022617 extracellular matrix disassembly IMP 21119006
GO:0035023 regulation of Rho protein signal transduction IEA --
GO:0072659 protein localization to plasma membrane --
GO:0090002 establishment of protein localization to plasma membrane IMP 24612608
genes like me logo Genes that share ontologies with FLOT1: view

Compounds for FLOT1 Gene

(7) Novoseek inferred chemical compound relationships for FLOT1 Gene

Compound -log(P) Hits PubMed IDs
lipid 65.4 47
cholesterol 53.4 5
sucrose 47.4 5
ganglioside 25.6 1
latex 15.1 1
genes like me logo Genes that share compounds with FLOT1: view

Transcripts for FLOT1 Gene

Unigene Clusters for FLOT1 Gene

Flotillin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FLOT1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c
SP1: - - - - -
SP2: - - - - - - - - -
SP3:
SP4: - -
SP5: - -
SP6:
SP7: - - - - - - - -
SP8:

Relevant External Links for FLOT1 Gene

GeneLoc Exon Structure for
FLOT1
ECgene alternative splicing isoforms for
FLOT1

Expression for FLOT1 Gene

mRNA expression in normal human tissues for FLOT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FLOT1 Gene

This gene is overexpressed in Whole Blood (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FLOT1 Gene

SOURCE GeneReport for Unigene cluster for FLOT1 Gene Hs.179986

genes like me logo Genes that share expressions with FLOT1: view

Orthologs for FLOT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FLOT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FLOT1 36
  • 99.84 (n)
  • 99.77 (a)
FLOT1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FLOT1 36
  • 93.05 (n)
  • 99.06 (a)
FLOT1 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FLOT1 36
  • 92.74 (n)
  • 99.06 (a)
FLOT1 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Flot1 36
  • 89.93 (n)
  • 98.36 (a)
Flot1 16
Flot1 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FLOT1 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Flot1 36
  • 90.16 (n)
  • 98.13 (a)
lizard
(Anolis carolinensis)
Reptilia FLOT1 37
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia flot1 36
  • 72.2 (n)
  • 81.28 (a)
Str.7164 36
zebrafish
(Danio rerio)
Actinopterygii flot1a 36
  • 74.8 (n)
  • 80.62 (a)
flot1a 37
  • 77 (a)
OneToMany
flot1b 37
  • 79 (a)
OneToMany
wufb53d05 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007494 36
  • 66.43 (n)
  • 67.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta Flo-1 36
  • 66.35 (n)
  • 65 (a)
Flo-1 37
  • 63 (a)
OneToOne
Flo 38
  • 65 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4127 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 62 (a)
OneToOne
Species with no ortholog for FLOT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FLOT1 Gene

ENSEMBL:
Gene Tree for FLOT1 (if available)
TreeFam:
Gene Tree for FLOT1 (if available)

Paralogs for FLOT1 Gene

Paralogs for FLOT1 Gene

genes like me logo Genes that share paralogs with FLOT1: view

Variants for FLOT1 Gene

Sequence variations from dbSNP and Humsavar for FLOT1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs15297 -- 30,741,587(+) GGACT(G/T)TGGGG intron-variant
rs1059597 -- 30,727,892(-) GCCTT(C/T)TGATG utr-variant-3-prime
rs1059612 -- 30,741,178(-) CTAGG(A/G)GCAGG intron-variant
rs1064627 -- 30,730,764(-) AGGGC(C/T)GCTGG intron-variant
rs1136719 -- 30,728,143(-) CAGGT(A/C/G)AATCA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for FLOT1 Gene

Variant ID Type Subtype PubMed ID
esv2731791 CNV Deletion 23290073
esv2670269 CNV Deletion 23128226
nsv830626 CNV Loss 17160897
dgv1917e1 CNV Complex 17122850
nsv884100 CNV Gain 21882294
nsv884101 CNV Gain 21882294
nsv884102 CNV Gain 21882294

Relevant External Links for FLOT1 Gene

HapMap Linkage Disequilibrium report
FLOT1

Disorders for FLOT1 Gene

(3) Novoseek inferred disease relationships for FLOT1 Gene

Disease -log(P) Hits PubMed IDs
alzheimers disease 34.5 5
neurofibrillary tangles 25.7 1
neurodegenerative diseases 0 1

Relevant External Links for FLOT1

Genetic Association Database (GAD)
FLOT1
Human Genome Epidemiology (HuGE) Navigator
FLOT1
genes like me logo Genes that share disorders with FLOT1: view

No data available for UniProtKB/Swiss-Prot for FLOT1 Gene

Publications for FLOT1 Gene

  1. Flotillin-1: gene structure: cDNA cloning from human lung and the identification of alternative polyadenylation signals. (PMID: 11167132) Edgar A.J. … Polak J.M. (Int. J. Biochem. Cell Biol. 2001) 3 4 23
  2. [Lipid rafts, flotillin-1 and Alzheimer disease]. (PMID: 14708344) Girardot N. … Duyckaerts C. (J. Soc. Biol. 2003) 3 23
  3. Human neuroglobin interacts with flotillin-1, a lipid raft microdomain-associated protein. (PMID: 15120622) Wakasugi K. … Morishima I. (Biochem. Biophys. Res. Commun. 2004) 3 23
  4. Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites. (PMID: 15128873) Haglund K. … Dikic I. (J. Cell. Sci. 2004) 3 23
  5. Flotillin 2 is distinct from epidermal surface antigen (ESA) and is associated with filopodia formation. (PMID: 10462713) Hazarika P. … Duvic M. (J. Cell. Biochem. 1999) 3 23

Products for FLOT1 Gene

Sources for FLOT1 Gene

Back to Top

Content