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FLOT1 Gene

protein-coding   GIFtS: 62
GCID: GC06M030695

Flotillin 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Flotillin 11 2
flotillin-12
Integral Membrane Component Of Caveolae2

External Ids:    HGNC: 37571   Entrez Gene: 102112   Ensembl: ENSG000001373127   OMIM: 6069985   UniProtKB: O759553   

Export aliases for FLOT1 gene to outside databases

Previous GC identifers: GC06M030751 GC06M030466 GC06M030801 GC06M030803


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FLOT1 Gene:
Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction.
FLOT1 encodes a caveolae-associated, integral membrane protein. The function of flotillin 1 has not been
determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for FLOT1 Gene:
FLOT1 (flotillin 1) is a protein-coding gene. Diseases associated with FLOT1 include mycobacterium marinum, and scrapie. GO annotations related to this gene include ionotropic glutamate receptor binding. An important paralog of this gene is FLOT2.

UniProtKB/Swiss-Prot: FLOT1_HUMAN, O75955
Function: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of
caveolae or caveolae-like vesicles

Gene Wiki entry for FLOT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NT_113891.3  NT_167245.2  NT_167248.2  NT_167249.2  NC_018917.2  NT_167244.2  
NT_167246.2  NT_167247.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FLOT1 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFLOT1 promoter sequence
   Search Chromatin IP Primers for FLOT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FLOT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

FLOT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FLOT1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M030695:  view genomic region     (about GC identifiers)

Start:
30,695,486 bp from pter      End:
30,710,510 bp from pter
Size:
15,025 bases      Orientation:
minus strand

Selected alternative locations (see all 7):
Chr6-,NT_167246 2,043,605-2,058,547      Chr6-,NT_167249 2,027,818-2,042,770      Chr6-,NT_167247 2,077,394-2,090,996     
Chr6-,NT_113891.2 2,207,577-2,222,522      Chr6-,NT_167248 1,988,443-2,003,382      Chr6-,NT_167245 1,989,169-2,004,112     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FLOT1_HUMAN, O75955 (See protein sequence)
Recommended Name: Flotillin-1  
Size: 427 amino acids; 47355 Da
Subunit: Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2 (By similarity).
Interacts with ECM29
Secondary accessions: Q969J8 Q9UHW1 Q9UNV8

Explore the universe of human proteins at neXtProt for FLOT1: NX_O75955

Explore proteomics data for FLOT1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys78, Lys211, Lys422
  • Modification sites at PhosphoSitePlus

  • See FLOT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005794.1  
    ENSEMBL proteins: 
     ENSP00000365569   ENSP00000395333   ENSP00000400615   ENSP00000404300   ENSP00000398834  
     ENSP00000412058   ENSP00000391341   ENSP00000394375  

    FLOT1 Human Recombinant Protein Products:

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    FLOT1 Assay Products:

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    Cloud-Clone Corp. ELISAs for FLOT1
    Cloud-Clone Corp. CLIAs for FLOT1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001107 Band_7
     IPR027705 Flotillin_fam

    Graphical View of Domain Structure for InterPro Entry O75955

    ProtoNet protein and cluster: O75955

    1 Blocks protein domain: IPB004851 Flotillin

    UniProtKB/Swiss-Prot: FLOT1_HUMAN, O75955
    Similarity: Belongs to the band 7/mec-2 family. Flotillin subfamily


    FLOT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FLOT1_HUMAN, O75955
    Function: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of
    caveolae or caveolae-like vesicles

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15469992
    GO:0035255ionotropic glutamate receptor binding IEA--
         
    FLOT1 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Flot1):
     cellular  hematopoietic system  immune system 

    FLOT1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Flot1tm1.1Arte for FLOT1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FLOT1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FLOT1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FLOT1

    miRNA
    Products:
        
    miRTarBase miRNAs that target FLOT1:
    hsa-mir-214-3p (MIRT024958), hsa-mir-320a (MIRT044822), hsa-mir-484 (MIRT041850), hsa-mir-182-5p (MIRT047187)

    Block miRNA regulation of human, mouse, rat FLOT1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate FLOT1:
    hsa-miR-31 hsa-miR-124 hsa-miR-182 hsa-miR-1914* hsa-miR-506 hsa-miR-1271 hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidFLOT1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for FLOT1
    Predesigned siRNA for gene silencing in human, mouse, rat FLOT1

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    GenScript: all cDNA clones in your preferred vector: FLOT1 (NM_005803)
    Sino Biological Human cDNA Clone for FLOT1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FLOT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLOT1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLOT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FLOT1_HUMAN, O75955: Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein.
    Melanosome. Endosome. Note=Membrane-associated protein of caveolae. Identified by mass spectrometry in melanosome
    fractions from stage I to stage IV
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    plasma membrane5
    cytoskeleton4
    cytosol2
    vacuole2
    extracellular1
    golgi apparatus1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IDA17897319
    GO:0005768endosome IDA--
    GO:0005815microtubule organizing center IDA18000879
    GO:0005886plasma membrane ----
    GO:0005901caveola TAS9153235

    FLOT1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FLOT1 About    
    See pathways by source

    SuperPathContained pathways About
    1Beta-Adrenergic Signaling
    Insulin Receptor Pathway0.37
    2Translation Insulin regulation of translation
    Insulin signaling pathway0.32
    3Insulin Signaling
    Insulin Signaling
    4Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for FLOT1
        Insulin Receptor Pathway

    1 Cell Signaling Technology (CST) Pathway for FLOT1
        Cytoskeletal Signaling

    1 BioSystems Pathway for FLOT1
        Insulin Signaling



    1 Kegg Pathway  (Kegg details for FLOT1):
        Insulin signaling pathway


    FLOT1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FLOT1
    Interactions:

        GeneGlobe Interaction Network for FLOT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for FLOT1 (O759551, 2, 3 ENSP000003655694) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPP050671, 3, ENSP000002849814EBI-603643,EBI-77613 I2D: score=3 STRING: ENSP00000284981
    FLOT2Q142541, 2, 3, ENSP000003783684EBI-603643,EBI-348613 MINT-3974647 MINT-3974663 I2D: score=4 STRING: ENSP00000378368
    ARG1P050892, 3, ENSP000003570664MINT-3974680 I2D: score=3 STRING: ENSP00000357066
    SORBS2O948753, ENSP000002847764I2D: score=4 STRING: ENSP00000284776
    FYNP062413, ENSP000003576564I2D: score=2 STRING: ENSP00000357656
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007409axonogenesis IEA--
    GO:0035023regulation of Rho protein signal transduction IEA--
    GO:0072659protein localization to plasma membrane IEA--

    FLOT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FLOT1

    7 Novoseek inferred chemical compound relationships for FLOT1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipid 65.4 60 15713660 (5), 17634952 (4), 16480949 (3), 19298817 (2) (see all 35)
    cholesterol 53.4 5 15863835 (1), 11408588 (1), 12586368 (1), 12450400 (1) (see all 5)
    sucrose 47.4 5 20200506 (1), 16439800 (1), 14598323 (1), 17464212 (1) (see all 5)
    ganglioside 25.6 1 12687620 (1)
    latex 15.1 1 19815536 (1)
    atp 0 1 15863835 (1)
    glucose 0 1 12943682 (1)

    1 PharmGKB related drug/compound annotation for FLOT1 gene    About this table
    Drug/compound PharmGKB Annotation
    carbamazepineCA  



    FLOT1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FLOT1 gene: 
    NM_005803.2  

    Unigene Cluster for FLOT1:

    Flotillin 1
    Hs.179986  [show with all ESTs]
    Unigene Representative Sequence: AF089750
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000487376 ENST00000376389(uc003nrm.3 uc011dmr.2) ENST00000413165
    ENST00000476729 ENST00000438162 ENST00000470643 ENST00000418160 ENST00000445853
    ENST00000484168 ENST00000416018 ENST00000454845 ENST00000484693 ENST00000456573

    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate FLOT1:
    hsa-miR-31 hsa-miR-124 hsa-miR-182 hsa-miR-1914* hsa-miR-506 hsa-miR-1271 hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidFLOT1 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat FLOT1
      QuantiFast Probe-based Assays in human, mouse, rat FLOT1

    Additional mRNA sequence: 

    AF085357.1 AF089750.2 AF117234.1 AK000816.1 AK222530.1 AK301291.1 BC001146.1 BC128154.1 
    BT007077.1 CR456946.1 

    Selected DOTS entries (see all 43):

    DT.40107534  DT.40198434  DT.87079601  DT.121371240  DT.121371139  DT.121370922  DT.121371151  DT.100669171 
    DT.121370835  DT.95167367  DT.100669175  DT.100669173  DT.121371220  DT.95079785  DT.121370936  DT.92447725 
    DT.121371142  DT.100669172  DT.100060337  DT.92447727  DT.95167378  DT.100060333  DT.100669174  DT.121371082 

    Selected AceView cDNA sequences (see all 117):

    AF089750 CR595648 N39789 BX111025 BC001146 NM_005803 R80075 AI475758 
    AA503425 AK000816 AF085357 AA350064 BF847902 CR456946 N40908 BF769657 
    AF117234 BF813951 CD621225 BT007077 AI355331 BF770051 CB120492 AW375398 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FLOT1 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c
    SP1:        -           -                 -           -     -                                                                                 
    SP2:        -           -                 -           -     -                                   -     -     -     -                           
    SP3:                                                                                                                                          
    SP4:        -           -                                                                                                                     
    SP5:                                                  -     -                                                                                 


    ECgene alternative splicing isoforms for FLOT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    FLOT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGCCTTCT
    FLOT1 Expression
    About this image


    FLOT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    FLOT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FLOT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.179986
        Custom PCR Arrays for FLOT1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLOT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FLOT1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Flot11 , 5 flotillin 11, 5 89.93(n)1
    98.36(a)1
      17 (18.70 cM)5
    142511  NM_008027.21  NP_032053.11 
     358232305 
    lizard
    (Anolis carolinensis)
    Reptilia FLOT16
    flotillin 1
    74(a)
    1 ↔ 1
    GL343623.1(42-50959)
    African clawed frog
    (Xenopus laevis)
    Amphibia AF545660.12   -- 75.11(n)    AF545660.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb53d052 Danio rerio cDNA clone MGC56406 IMAGE5605227, complete more 77.66(n)    AY398349.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Flo3
    Flo-11
    biological_process unknown structural
    molecule3
    Flotillin-11
    65(a)3
    66.35(n)1
    65(a)1
      52A133
    367261  NM_166102.11  NP_725476.11 


    ENSEMBL Gene Tree for FLOT1 (if available)
    TreeFam Gene Tree for FLOT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FLOT1 gene
    FLOT22  
    1 SIMAP similar gene for FLOT1 using alignment to 11 protein entries:     FLOT1_HUMAN (see all proteins):
    FLOT2

    FLOT1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FLOT1 (see all 367)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs716954451,2
    C--30624886(+) GACAG-/CCTG  
            
    AGAGG
    1 -- int10--------
    rs1878795051,2
    --30695071(+) ATCATC/GGCTCA 1 -- int10--------
    rs1906215781,2
    --30695084(+) ACAGCC/TTTAGA 1 -- int10--------
    rs764510481,2
    C,F--30695136(+) AGCTAG/AGACTA 1 -- int13Minor allele frequency- A:0.09WA NA EA 358
    rs1467155981,2
    C--30695186(+) TTCTC-/TTTTTT 1 -- int10--------
    rs94616251,2
    C--30695239(+) TGGTGC/TGATCT 1 -- int10--------
    rs1411296211,2
    --30695240(+) GGTGCA/GATCTT 1 -- int10--------
    rs1469428861,2
    --30695411(+) CCTGAC/GCTCAG 1 -- int10--------
    rs94688171,2
    C--30695469(+) AGCCAC/TTGTGC 1 -- int13Minor allele frequency- T:0.12WA EA 240
    rs1842098001,2
    --30695507(+) TCTGTC/TTTATT 1 -- int10--------

    HapMap Linkage Disequilibrium report for FLOT1 (30695486 - 30710510 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for FLOT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670269CNV Deletion23128226
    esv2731791CNV Deletion23290073
    nsv830626CNV Loss17160897
    nsv884101CNV Gain21882294
    nsv884100CNV Gain21882294
    nsv884102CNV Gain21882294
    dgv1917e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FLOT1
    DNA2.0 Custom Variant and Variant Library Synthesis for FLOT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606998    OMIM disorders: --

    Selected diseases for FLOT1 (see all 24):    
    About MalaCards
    mycobacterium marinum    scrapie    primary open angle glaucoma    open-angle glaucoma
    mantle cell lymphoma    bardet-biedl syndrome    glaucoma    alzheimer's disease
    malaria    systemic lupus erythematosus    tonsillitis    neuroblastoma
    lupus erythematosus    ulcerative colitis    oral squamous cell carcinoma    cholangiocarcinoma
    pneumonia    multiple sclerosis    cerebritis    hiv-1


    FLOT1 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for FLOT1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 34.5 5 14507337 (2), 14708344 (2), 15869502 (1)
    neurofibrillary tangles 25.7 1 14708344 (1)
    neurodegenerative diseases 0 1 16480949 (1)

    Genetic Association Database (GAD): FLOT1
    Human Genome Epidemiology (HuGE) Navigator: FLOT1 (5 documents)

    Export disorders for FLOT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FLOT1 gene, integrated from 10 sources (see all 141):
    (articles sorted by number of sources associating them with FLOT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Flotillin-1: gene structure: cDNA cloning from human lung and the identification of alternative polyadenylation signals. (PubMed id 11167132)1, 2, 9 Edgar A.J. and Polak J.M. (Int. J. Biochem. Cell Biol. 2001)
    2. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PubMed id 20682791)1, 2 Gorbea C.... Rechsteiner M. (J. Biol. Chem. 2010)
    3. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
    4. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)
    5. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    8. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    9. PTOV1 enables the nuclear translocation and mitogenic activity of flotillin-1, a major protein of lipid rafts. (PubMed id 15713644)1, 9 Santamaria A.... Paciucci R. (Mol. Cell. Biol. 2005)
    10. Flotillin-1 stabilizes caveolin-1 in intestinal epithelial cells. (PubMed id 19121286)1, 9 Vassilieva E.V....Nusrat A. (Biochem. Biophys. Res. Commun. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10211 HGNC: 3757 AceView: FLOT1 Ensembl:ENSG00000137312 euGenes: HUgn10211
    ECgene: FLOT1 Kegg: 10211 H-InvDB: FLOT1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FLOT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FLOT1 gene:
    Search GeneIP for patents involving FLOT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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