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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FLOT1 Gene

protein-coding GIFtS: 60
GCID: GC06M030695

flotillin 1

Explore 19 diseases affiliated with
FLOT1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Flotillin 1¹ ²
Flotillin-1¹
Integral Membrane Component Of Caveolae²

External Ids:	HGNC: 3757¹	Entrez Gene: 10211²	Ensembl: ENSG00000137312⁷	OMIM: 606998⁵	UniProtKB: O75955³

Export aliases for FLOT1 gene to outside databases

Previous GC identifers: GC06M030751 GC06M030466 GC06M030801 GC06M030803

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FLOT1:

Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. FLOT1

encodes a caveolae-associated, integral membrane protein. The function of flotillin 1 has not been determined.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FLOT1_HUMAN, O75955

Function: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of

caveolae or caveolae-like vesicles

Gene Wiki entry for FLOT1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167244.1 NT_167245.1 NT_167246.1 NT_167247.1

NT_167248.1 NT_167249.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FLOT1 gene promoter:
AML1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FLOT1 promoter sequence

Search SABiosciences Chromatin IP Primers for FLOT1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FLOT1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21.3

FLOT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FLOT1 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M030695: view genomic region (about GC identifiers)

Start:	30,695,486 bp from pter	End:	30,710,510 bp from pter
Size:	15,025 bases	Orientation:	minus strand

6/7 alternative locations (see all 7):

Chr6-,ALT_REF_LOCI_2 30,685,348-30,739,506	Chr6-,ALT_REF_LOCI_1 30,703,731-30,714,825	Chr6-,ALT_REF_LOCI_3 30,685,747-30,711,753
Chr6-,ALT_REF_LOCI_6 30,685,021-30,735,566	Chr6-,ALT_REF_LOCI_4 30,663,264-30,678,206	Chr6-,ALT_REF_LOCI_5 30,688,817-30,702,419

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FLOT1_HUMAN, O75955 (See protein sequence)

Recommended Name: Flotillin-1

Size: 427 amino acids; 47355 Da

Subunit: Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2 (By similarity).

Interacts with ECM29

Subcellular location: Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein.

Melanosome. Endosome. Note=Membrane-associated protein of caveolae. Identified by mass spectrometry in melanosome

fractions from stage I to stage IV

Secondary accessions: Q969J8 Q9UHW1 Q9UNV8

Explore the universe of human proteins at neXtProt for FLOT1: NX_O75955

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O75955

FLOT1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005794.1

ENSEMBL proteins:

ENSP00000365569 ENSP00000395333 ENSP00000400615 ENSP00000404300 ENSP00000398834

ENSP00000412058 ENSP00000391341 ENSP00000394375

Human Recombinant Protein Products for FLOT1:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: FLOT1 OriGene Protein Over-expression Lysate: FLOT1 OriGene Custom Protein Services for FLOT1
	GenScript Custom Purified and Recombinant Proteins Services for FLOT1
	Novus Biologicals FLOT1 Proteins Novus Biologicals FLOT1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for FLOT1

Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005768	endosome	IDA	--
GO:0005815	microtubule organizing center	IDA	18000879
GO:0005886	plasma membrane	--	--
GO:0005901	caveola	TAS	9153235

FLOT1 for ontologies About GeneDecksing

FLOT1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of FLOT1
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	Cell Signaling Technology (CST) Antibodies for FLOT1
	OriGene Antibodies (see all 2): FLOT1 OriGene Custom Antibody Services for FLOT1
	GenScript Custom Superior Antibodies Services for FLOT1
	Novus Biologicals FLOT1 Antibodies
	Abcam antibodies for FLOT1
	Uscn Antibodies for FLOT1
	ThermoFisher Antibodies for FLOT1

Assay Products for FLOT1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for FLOT1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FLOT1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FLOT1 for domains About GeneDecksing

1 InterPro domain/family:

IPR001107 Band_7

Graphical View of Domain Structure for InterPro Entry O75955

ProtoNet protein and cluster: O75955

1 Blocks protein family: IPB004851 Flotillin

UniProtKB/Swiss-Prot: FLOT1_HUMAN, O75955

Similarity: Belongs to the band 7/mec-2 family. Flotillin subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: FLOT1_HUMAN, O75955

Function: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of

caveolae or caveolae-like vesicles

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	15469992
GO:0035255	ionotropic glutamate receptor binding	IEA	--

FLOT1 for ontologies About GeneDecksing

Phenotypes:
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Flot1):

cellular

immune system

FLOT1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Flot1^tm1.1Arte for FLOT1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FLOT1

miRNA Products:		OriGene 3'-UTR Clone: FLOT1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FLOT1
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate FLOT1:
		hsa-miR-31 hsa-miR-124 hsa-miR-182 hsa-miR-1914* hsa-miR-506 hsa-miR-1271 hsa-miR-96
		SwitchGear 3'UTR luciferase reporter plasmid: FLOT1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FLOT1 (see all 7) OriGene shRNA RFP: FLOT1 OriGene siRNA: FLOT1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FLOT1
		Sirion Biotech Custom design and validation of potent shRNA sequences against FLOT1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for FLOT1
			Sirion Biotech Customized adenovirus for overexpression of FLOT1 Sirion Biotech Customized adenovirus for potent knockdown of FLOT1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FLOT1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FLOT1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FLOT1 (NM_005803)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FLOT1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLOT1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FLOT1
		Search LifeMap BioReagents cell lines for FLOT1
		Sirion Biotech Customized stable knockdown cell line services for FLOT1 Sirion Biotech Customized inducible knockdown cell line services for FLOT1 Sirion Biotech Customized stable overexpressing cell line services for FLOT1 Sirion Biotech Customized inducible overexpressing cell line services for FLOT1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLOT1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cytoskeletal Signaling

Cytoskeletal Signaling

1.00

Insulin Signaling

Insulin Signaling

1.00

Erythropoietin Pathway

Insulin Receptor Pathway

0.37

Development_CNTF receptor signaling

Insulin signaling pathway

0.17

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for FLOT1

Insulin Receptor Pathway

1 Cell Signaling Technology (CST) Pathway for FLOT1

Cytoskeletal Signaling

1 BioSystems Pathway for FLOT1

Insulin Signaling

1 Kegg Pathway (Kegg details for FLOT1):

Insulin signaling pathway

FLOT1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FLOT1

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/35 Interacting proteins for FLOT1 (O75955^{1, 2, 3} ENSP00000365569⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 35)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APP	P05067¹^,³, ENSP00000284981⁴	EBI-603643,EBI-77613 I2D: score=3 STRING: ENSP00000284981
FLOT2	Q14254²^,³, ENSP00000378368⁴	MINT-3974647 MINT-3974663 I2D: score=4 STRING: ENSP00000378368
ARG1	P05089²^,³, ENSP00000357066⁴	MINT-3974680 I2D: score=3 STRING: ENSP00000357066
SORBS2	O94875³, ENSP00000284776⁴	I2D: score=4 STRING: ENSP00000284776
FYN	P06241³, ENSP00000357656⁴	I2D: score=2 STRING: ENSP00000357656

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007409	axonogenesis	IEA	--
GO:0035023	regulation of Rho protein signal transduction	IEA	--
GO:0072659	protein localization to plasma membrane	IEA	--

FLOT1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FLOT1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FLOT1
7 Novoseek chemical compound relationships for FLOT1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lipid	65.4	60	15713660 (5), 17634952 (4), 16480949 (3), 19298817 (2) (see all 35)
cholesterol	53.4	5	15863835 (1), 11408588 (1), 12586368 (1), 12450400 (1) (see all 5)
sucrose	47.4	5	20200506 (1), 16439800 (1), 14598323 (1), 17464212 (1) (see all 5)
ganglioside	25.6	1	12687620 (1)
latex	15.1	1	19815536 (1)
atp	0	1	15863835 (1)
glucose	0	1	12943682 (1)

1 PharmGKB related drug/compound annotation for FLOT1 gene About this table

Drug/compound	PharmGKB Annotation
carbamazepine	CA

Search CenterWatch for drugs/clinical trials and news about FLOT1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FLOT1 gene:

NM_005803.2

Unigene Cluster for FLOT1:

Flotillin 1

Hs.179986 [show with all ESTs]

Unigene Representative Sequence: AF089750

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000376389(uc003nrm.3 uc011dmr.2) ENST00000487376 ENST00000413165

ENST00000476729 ENST00000438162 ENST00000470643 ENST00000418160 ENST00000445853

ENST00000484168 ENST00000416018 ENST00000454845 ENST00000484693 ENST00000456573

miRNA Products:		OriGene 3'-UTR Clone: FLOT1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FLOT1
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate FLOT1:
		hsa-miR-31 hsa-miR-124 hsa-miR-182 hsa-miR-1914* hsa-miR-506 hsa-miR-1271 hsa-miR-96
		SwitchGear 3'UTR luciferase reporter plasmid: FLOT1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FLOT1 (see all 7) OriGene shRNA RFP: FLOT1 OriGene siRNA: FLOT1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FLOT1
		Sirion Biotech Custom design and validation of potent shRNA sequences against FLOT1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FLOT1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FLOT1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FLOT1 (NM_005803)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FLOT1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLOT1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FLOT1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FLOT1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FLOT1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FLOT1

Additional cDNA sequence:

AF085357.1 AF089750.2 AF117234.1 AK000816.1 AK222530.1 AK301291.1 BC001146.1 BC128154.1

BT007077.1 CR456946.1

24/41 DOTS entries (see all 41):

DT.40107534 DT.40198434 DT.87079601 DT.121371240 DT.121371151 DT.121370922 DT.121371139 DT.95167367

DT.100669171 DT.121370835 DT.100669175 DT.121370936 DT.121371220 DT.92447725 DT.95079785 DT.100669173

DT.121371142 DT.100669172 DT.100060337 DT.92447727 DT.100060333 DT.100669174 DT.121371082 DT.121371272

24/117 AceView cDNA sequences (see all 117):

AF089750 AI475758 BC001146 NM_005803 CR595648 BX111025 N39789 R80075

CR456946 AK000816 BF847902 BF770051 AA350064 AA503425 CB120492 AW375398

BT007077 CD621225 AF085357 N40908 AF117234 BF769657 BF813951 AI355331

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for FLOT1 (see all 8) About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15a	·	15b	·	15c
SP1:			-				-						-				-		-
SP2:			-				-						-				-		-												-		-		-		-
SP3:
SP4:			-				-
SP5:																	-		-

ECgene alternative splicing isoforms for FLOT1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FLOT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCAGCCTTCT

About this image

FLOT1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FLOT1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FLOT1

SOURCE GeneReport for Unigene cluster: Hs.179986

SABiosciences Custom PCR Arrays for FLOT1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FLOT1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FLOT1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FLOT1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FLOT1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLOT1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for FLOT1 gene from 7/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Flot1^{1 , 5}	flotillin 1^{1, 5}	89.93(n)¹ 98.36(a)¹		17 (18.70 cM)⁵ 14251¹ NM_008027.2¹ NP_032053.1¹ 35823230⁵
lizard (Anolis carolinensis)	Reptilia	FLOT1⁶	--	81(a)	1 ↔ 1	GL343623.1(3200-44298)
African clawed frog (Xenopus laevis)	Amphibia	AF545660.1²	--	75.11(n)		AF545660.1
zebrafish (Danio rerio)	Actinopterygii	wufb53d05²	Danio rerio cDNA clone MGC56406 IMAGE5605227, complete more	77.66(n)		AY398349.1
fruit fly (Drosophila melanogaster)	Insecta	Flo^{1 , 3}	biological_process unknown structural molecule³ flotillin¹	65(a)³ 66.35(n)¹ 65(a)¹		52A13³ 36726¹ NM_058010.3¹ NP_477358.1¹
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G25260⁶ AT5G25250⁶ (see all 3)	Flotillin-like protein 1 (see all 3)	15(a) 15(a) (see all 3)	possible ortholog possible ortholog (see all 3)	5(8752684-8754485) 5(8749727-8751636)
rice (Oryza sativa)	Liliopsida	-- -- (see all 3)	nodulin, putative (see all 3)	15(a) 13(a) (see all 3)	possible ortholog possible ortholog (see all 3)	10(18097662-18100875) 10(18143113-18146332)

ENSEMBL Gene Tree for FLOT1 (if available)
TreeFam Gene Tree for FLOT1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FLOT1 gene

FLOT2²

1 SIMAP similar gene for FLOT1 using alignment to 26 protein entries: FLOT1_HUMAN (see all proteins):

FLOT2

FLOT1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs187879505^1,2		--	30695071(+)	`ATCATC/GGCTCA`	1	--	int¹		0	--	--	--	--
rs190621578^1,2		--	30695084(+)	`ACAGCC/TTTAGA`	1	--	int¹		0	--	--	--	--
rs76451048^1,2	F	--	30695136(+)	`AGCTAG/AGACTA`	1	--	int¹		3		WA NA EA	358
rs146715598^1,2	C	--	30695186(+)	`TTCTC-/TTTTTT`	1	--	int¹		0	--	--	--	--
rs9461625^1,2		--	30695239(+)	`TGGTGC/TGATCT`	1	--	int¹		0	--	--	--	--
rs141129621^1,2		--	30695240(+)	`GGTGCA/GATCTT`	1	--	int¹		0	--	--	--	--
rs146942886^1,2		--	30695411(+)	`CCTGAC/GCTCAG`	1	--	int¹		0	--	--	--	--
rs9468817^1,2	C	--	30695469(+)	`AGCCAC/TTGTGC`	1	--	int¹		3		WA EA	240
rs184209800^1,2		--	30695507(+)	`TCTGTC/TTTATT`	1	--	int¹		0	--	--	--	--
rs116450060^1,2		--	30695518(+)	`AGTACT/GTACTT`	1	--	ut3¹		1		NA	120

HapMap Linkage Disequilibrium report for FLOT1 (30695486 - 30710510 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FLOT1
1 CNV: 3600
1 Indel: 40848

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FLOT1 for disorders           About GeneDecksing

OMIM gene information: 606998    OMIM disorders: --

19 diseases for FLOT1:    About MalaCards

open-angle glaucoma mycobacterium marinum primary open angle glaucoma bardet-biedl syndrome

mantle cell lymphoma systemic lupus erythematosus lupus erythematosus glaucoma

neurodegenerative disease scrapie alzheimer's disease breast carcinoma

breast cancer cholesterol neuroblastoma carcinoma

malaria prostatitis neuronitis

3 Novoseek disease relationships for FLOT1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
alzheimers disease	34.5	5	14507337 (2), 14708344 (2), 15869502 (1)
neurofibrillary tangles	25.7	1	14708344 (1)
neurodegenerative diseases	0	1	16480949 (1)

Human Genome Epidemiology (HuGE) Navigator: FLOT1 (5 documents)

Export disorders for FLOT1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FLOT1 gene, integrated from 9 sources (see all 124):
(articles sorted by number of sources associating them with FLOT1)

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world of online information

Flotillin-1: gene structure: cDNA cloning from human lung and the identification of alternative polyadenylation signals. (PubMed id 11167132)^{1, 2, 9} Edgar A.J. and Polak J.M. (2001)
A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PubMed id 20682791)^{1, 2} Gorbea C.... Rechsteiner M. (2010)
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)^{1, 2} Chi A....Hunt D.F. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)^{1, 2} Hu R.-M.... Chen J.-L. (2000)
Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)^{1, 2} Zhang Q.-H.... Chen Z. (2000)
Flotillin-1 stabilizes caveolin-1 in intestinal epithelial cells. (PubMed id 19121286)^{1, 9} Vassilieva E.V....Nusrat A. (2009)
Expression, purification, and characterization of recombinant human flotillin-1 in Escherichia coli. (PubMed id 15939299)^{1, 9} Ding Y....Zhang Z. (2005)
Human neuroglobin interacts with flotillin-1, a lipid raft microdomain-associated protein. (PubMed id 15120622)^{1, 9} Wakasugi K....Morishima I. (2004)
Flotillin-1 in the substantia nigra of the Parkinson brain and a predominant localization in catecholaminergic nerves in the rat brain. (PubMed id 15545008)^{1, 9} Jacobowitz D.M. and Kallarakal A.T. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10211	HGNC: 3757	AceView: FLOT1	Ensembl:ENSG00000137312	euGenes: HUgn10211
ECgene: FLOT1	Kegg: 10211	H-InvDB: FLOT1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FLOT1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FLOT1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FLOT1 gene:
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