Aliases for FLNC Gene
External Ids for FLNC Gene
Previous HGNC Symbols for FLNC Gene
Previous GeneCards Identifiers for FLNC Gene
This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for FLNC Gene
FLNC (Filamin C) is a Protein Coding gene. Diseases associated with FLNC include Myopathy, Distal, 4 and Myopathy, Myofibrillar, 5. Among its related pathways are Cell junction organization and SMAD Signaling Network. GO annotations related to this gene include actin filament binding and ankyrin binding. An important paralog of this gene is FLNA.
UniProtKB/Swiss-Prot for FLNC Gene
Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers.