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FLNC Gene

protein-coding GIFtS: 66

GC07P128257

filamin C, gamma (actin binding protein 280)
(Previous names: filamin C, gamma (actin-binding protein-280) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: FLN2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ABP-280 ^¹, ²
ABP-L ^³
ABP280A ^²
ABPA ^², ⁵
ABPL ^¹, ², ³, ⁵
FLJ10186 ^²
FLN2 ^², ³, ⁵
Filamin-2 ^³
Gamma-filamin ^³

Descriptions
ABP-280-like protein ^³
ABP-L, gamma filamin ^²
Actin-binding-like protein ^³
Protein FLNc ^³
filamin 2 ^²
filamin C, gamma (actin binding protein 280) ^²
filamin C, gamma (actin-binding protein-280) ^¹
gamma filamin ^²

External Ids
HGNC: 3756¹
Entrez Gene: 2318²
UniProtKB: Q14315³
Ensembl: ENSG00000128591⁷

Search outside databases for aliases for FLNC gene

Previous GC identifers: GC07M127029 GC07P126948 GC07P128010 GC07P128024 GC07P128064

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FLNC:

This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin

proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate

in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist

in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain,

and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms

have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: FLNC_HUMAN, Q14315

Function: Muscle-specific filamin, which plays a central role in muscle cells, probably by

functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin

cytoskeleton in response to signaling events, and may also display structural functions at the

Z-disks in muscle cells

Gene Wiki entry for FLNC

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FLNC gene

Entrez Gene cytogenetic band: 7q32-q35 Ensembl cytogenetic band: 7q32.1 HGNC cytogenetic band: 7q32-q35

FLNC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P128257: (about GC identifiers)

Start:	128,257,719 bp from pter
End:	128,286,572 bp from pter
Size:	28,854 bases
Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 127,854,228-127,883,081

RefSeq DNA sequence:

NC_000007.12 NT_007933.14 NT_079596.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: FLNC_HUMAN, Q14315 (See protein sequence)

Recommended Name: Filamin-C

Size: 2725 amino acids; 290959 Da

Subunit: Homodimer. Interacts with KY (By similarity). Interacts with FLNB, KCND2, ITGB1A, INPPL1,

MYOT, MYOZ1 and MYOZ3. Interacts with sarcoglycans SGCD and SGCG

Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton.

Cytoplasm, myofibril, sarcomere, Z-disk. Note=A small amount localizes at membranes. In striated

muscle cells, it predominantly localizes in myofibrillar Z-disks, while a minor fraction localizes

with subsarcolemme

Developmental stage: Expressed in both differentiating and adult muscles

Miscellaneous: Silenced in MKN28 and MKN74 gastric cancer cell lines due to aberrant methylation of

the gene

Sequence caution: Sequence=AAF80245.1; Type=Frameshift; Positions=2578, 2580, 2590;

PDB structures from and Proteopedia :

1V05 (3D)

2D7M (3D)

2D7N (3D)

2D7O (3D)

2D7P (3D)

2D7Q (3D)

2NQC (3D)

Secondary accessions: O95303 Q07985 Q9NS12 Q9NYE5 Q9UMR8 Q9Y503

Alternative splicing: 2 isoforms: Q14315-1 Q14315-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001120959.1 NP_001449.3

ENSEMBL proteins:

ENSP00000344002 ENSP00000327145 ENSP00000373505

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (FLNC)
	Human Recombinant Proteins from Abnova (FLNC)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005856	cytoskeleton	IEA	--
GO:0005886	plasma membrane	IDA	18029348

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Antibodies for FLNC:

	Invitrogen Antibodies for FLNC
	Millipore Mono- and Polyclonal Antibodies for the study of FLNC
	Sigma-Aldrich Antibodies for FLNC
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (FLNC), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (FLNC)
	Novus Biologicals Antibodies for FLNC

Assays for FLNC:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q14315

ProtoNet protein and cluster: Q14315

2 Blocks protein families:

IPB001589 Actin-binding

IPB001715 Calponin-like actin-binding

UniProtKB/Swiss-Prot: FLNC_HUMAN, Q14315

Domain: The intradomain insert is specific to FLNC and mediates the targeting to developing and

mature Z-disks

Domain: Comprised of a NH2-terminal actin-binding domain, 24 internally homologous repeats and two

hinge regions. Repeat 24 and the second hinge domain are important for dimer formation

Domain: The filamin 20 repeat mediates interaction with XIRP1

Similarity: Belongs to the filamin family

Similarity: Contains 1 actin-binding domain

Similarity: Contains 2 CH (calponin-homology) domains

Similarity: Contains 24 filamin repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FLNC)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FLNC)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001458

Applied Biosystems Silencer® siRNAs for FLNC

Sigma-Aldrich siRNA for FLNC

Sigma-Aldrich shRNA for FLNC

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001127487
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001127487
untagged cDNA clones in CMV expression vector (see all 3): NM_001127487

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001458

UniProtKB/Swiss-Prot: FLNC_HUMAN, Q14315

Function: Muscle-specific filamin, which plays a central role in muscle cells, probably by

functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin

cytoskeleton in response to signaling events, and may also display structural functions at the

Z-disks in muscle cells

Genatlas biochemistry entry for FLNC:

filamin C,dimeric actin cross-linking phosphoprotein of the peripheral cytoplasm

7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Flnc):

	behavior/neurological	growth/size	lethality-prenatal/perinatal	muscle
respiratory system	touch/vibrissae

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--
GO:0005515	protein binding	IPI	16076904

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for FLNC (Your Favorite Gene powered by Ingenuity)

Caveolar-mediated Endocytosis
Virus Entry via Endocytic Pathways

GeneDecks FLNC for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for FLNC

5/57 Interacting proteins for FLNC (Q14315^{1, 2} ENSP00000327145³) via UniProtKB, MINT, and/or STRING (see all 57 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SGCD	Q92629², ENSP00000338343³	MINT-14400 MINT-14402 MINT-14399 MINT-14401 STRING (score=.973)
SGCG	Q13326², ENSP00000218867³	MINT-15713 MINT-15712 MINT-15714 STRING (score=.966)
MYOZ1	Q9NP98², ENSP00000352272³	MINT-49882 MINT-49883 STRING (score=.999)
MYOT	Q9UBF9¹, ENSP00000239926³	EBI-489954, EBI-296701 STRING (score=.996)
ABL1	P00519¹	EBI-489954, EBI-375543

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FLNC
1 Novoseek chemical compound relationship for FLNC gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
calcium	0.00	1	16297652 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FLNC)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FLNC)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001458

Sigma-Aldrich siRNA for FLNC

Sigma-Aldrich shRNA for FLNC

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001127487 NM_001458

REFSEQ mRNAs for FLNC gene (2 alternative transcripts):

NM_001127487.1 NM_001458.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001127487 NM_001458

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001127487
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001127487
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001127487

Additional cDNA sequence:

AB208865.1 AB371585.1 AF089841.1 AF146692.1 AJ012737.1 AK001048.1 AK126540.1 X70083.1

X70084.1

9 DOTS entries:

DT.95176111 DT.100778267 DT.95185474 DT.100778266 DT.101977680 DT.100645175 DT.102840287 DT.121107385

DT.91767972

24/263 AceView cDNA sequences (see all 263 ):

BQ688982 AI217579 BQ687551 BF339068 BP341232 BP365940 BQ689211 AK126540

BQ671042 BQ688140 AL602841 BQ686327 BQ890092 BX499575 BQ878242 BM698365

BQ686444 BQ880730 X70084 BF432154 AI805005 BQ688470 CF552835 BU174316

highest scoring ESTs for FLNC:

AJ012737 AA055362 AA196586 AA196684 AA196747 AA196947 AA211736 AA216224 AA375131 AA404397

Unigene Cluster for FLNC:

Filamin C, gamma (actin binding protein 280)

Hs.58414 [show with all ESTs]

Unigene Representative Sequence: AB371585

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for FLNC

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24a	·	24b	^
SP1:
SP2:
SP3:

ExUns:	25	^	26	^	27	^	28	^	29	^	30	^	31	^	32	^	33	^	34	^	35	^	36	^	37	^	38	^	39	^	40	^	41	^	42	^	43	^	44	^	45	^	46	^	47	^	48
SP1:													-
SP2:
SP3:

About this scheme

ECgene alternative splicing isoforms for FLNC

3 Ensembl transcripts including schematic representations:

ENST00000346177 ENST00000325888 ENST00000388853

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FLNC expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FLNC

¹ / ² / ³

3 probe-sets matching FLNC gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35330_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AJ012737	1.00	1.00	1.00	1
207876_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001458	0.60	1.00	0.82	1
207876_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks FLNC for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CAGCTCAGCT

SOURCE GeneReport for Unigene cluster: Hs.58414
Expression variation in blood from EXPOLDB for FLNC
UniProtKB/Swiss-Prot: FLNC_HUMAN, Q14315
Tissue specificity: Highly expressed in striated muscles. Weakly expressed in thyroid, fetal brain,
fetal lung, retina, spinal cord and bone marrow. Not expressed in testis, pancreas, adrenal gland,
placenta, liver and kidney

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FLNC gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	FLNC¹	--	filamin C, gamma (actin binding protein 280)	92.11(n) 98.51(a)	482266 XM_852926.1 XP_858019.1
chimpanzee (Pan troglodytes)	FLNC¹	--	filamin C, gamma (actin binding protein 280)	96.12(n) 95.81(a)	463711 XM_519364.2 XP_519364.2
cow (Bos taurus)	FLNC¹	--	filamin C, gamma (actin binding protein 280)	91.94(n) 99(a)	528415 XM_001250544.1 XP_001250545.1
rat (Rattus norvegicus)	Flnc¹	--	filamin C, gamma (actin binding protein 280)	89.54(n) 98.28(a)	362332 XM_342653.3 XP_342654.2
mouse (Mus musculus)	Flnc^{1, 5}	6 (8.50 cM)⁵	filamin C, gamma^{1, 5}	89.6(n)¹ 98.31(a)¹	68794¹ NM_001081185.1¹ NP_001074654.1¹ AF119148⁵ AF353670⁵ (see all 16)

About this table Species with no ortholog for FLNC

ENSEMBL Gene Tree for FLNC

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FLNC gene

FLNA² FLNB² SYNE1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/103 NCBI SNPs in FLNC are shown (see all 103 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 99)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs754921^1,2	A,C,F	128255769(+)	`GCCACA/GCACAG`	1	--	ng5¹		8		NS MN EA	1764
	rs2291569^1,2	C,F,H	128275970(+)	`CGCACG/AGGACG`	2	Q/R	mis¹ ese³		11		EA NA WA EU	2330
	rs3807133^1,2	C,F	128256996(+)	`CAAACG/AGGCTG`	1	--	ng5¹		2		MN EA	1252
	rs3823480^1,2	C	128256117(+)	`TAGAAA/GGATGG`	1	--	ng5¹ tfbs³		0	--	--	--	--
	rs10269893^1,2	H	128276658(+)	`CAGGAG/TACGGT`	2	E/D	mis¹ ese³		4		EU EA WA	418
	rs2643766^1,2	H	128276084(+)	`TCAGGA/GCCCCG`	2	D/G	mis¹ ese³		2		EU WA	238
	rs3807132^1,2	F	128256720(+)	`CCTGGT/CCCTGC`	1	--	ng5¹		1		EA	1300
	rs3807131^1,2	F	128256061(+)	`AAACTT/CCTCAG`	1	--	ng5¹		1		EA	752
	rs2643767^1,2	H	128276140(+)	`CGTACA/GCTGTG`	2	T/A	mis¹ ese³		4		EU EA WA	410
--	rs2639138^1,2	C	128257718(+)	`CTCCGA/GCCCTG`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for FLNC (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 102565 disorders: 609524

UniProtKB/Swiss-Prot: FLNC_HUMAN, Q14315

Defects in FLNC are the cause of autosomal dominant filaminopathy [MIM:609524, 601419].

Myofibrillar myopathy (MFM) is a neuromuscular disorder, usually with an adult onset,

characterized by focal myofibrillar destruction and pathological cytoplasmic protein aggregations.

Autosomal dominant filaminopathy is a form of MFM characterized by morphological features of MFM

and clinical features of a limb-girdle myopathy. A heterozygous nonsense mutation which segregates

with the disease, has been identified in the FLNC gene

7 Novoseek disease relationships for FLNC gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
lgmd1a	92.50	1	12499399 (1)
muscular dystrophy limb-girdle	82.65	1	10629222 (1)
limb girdle	77.31	1	12499399 (1)
myopathy	74.43	11	15929027 (2), 17337483 (1), 18769253 (1), 19181098 (1) (see all 7)
muscular dystrophies	72.80	2	10629222 (1), 12499399 (1)
gastric cancer	1.70	2	12438262 (1), 15279900 (1)
melanoma	0.00	5	9006895 (2), 9392863 (1)

About this table

GeneTests: FLNC

Myofibrillar Myopathy

Human Gene Mutation Database: FLNC

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/86 PubMed articles for FLNC gene (see all 86 ):

Mapping of two genes encoding isoforms of the actin binding protein ABP-280, a dystrophin like protein, to Xq28 and to chromosome 7. (PubMed id 7689010)^{2, 3, 4} Maestrini E.... Toniolo D. (1993)
Filamin 2 (FLN2): a muscle-specific sarcoglycan interacting protein. (PubMed id 10629222)^{1, 3, 4} Thompson T.G.... Kunkel L.M. (2000)
A mutation in the dimerization domain of filamin C causes a novel type of autosomal dominant myofibrillar myopathy. (PubMed id 15929027)^{1, 3, 4} Vorgerd M.... Huebner A. (2005)
The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins. (PubMed id 16076904)^{1, 3, 4} Gontier Y.... Borradori L. (2005)
Characterization of muscle filamin isoforms suggests a possible role of gamma-filamin/ABP-L in sarcomeric Z-disc formation. (PubMed id 10658210)^{1, 3, 4} van der Ven P.F.M....Fuerst D.O. (2000)
Structural basis for vertebrate filamin dimerization. (PubMed id 15642266)^{1, 3, 4} Pudas R.... Ylaenne J. (2005)
Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins. (PubMed id 11842093)^{1, 3, 4} Frey N. and Olson E.N. (2002)
Identification of silencing of nine genes in human gastric cancers. (PubMed id 12438262)^{1, 3, 4} Kaneda A.... Ushijima T. (2002)
Myozenin: an alpha-actinin- and gamma-filamin-binding protein of skeletal muscle Z lines. (PubMed id 11171996)^{1, 3, 4} Takada F.... Beggs A.H. (2001)
Comparative mapping of the actin-binding protein 280 genes in human and mouse. (PubMed id 8088838)^{1, 2, 3} Gariboldi M....Antonacci R. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2318	HGNC: 3756	AceView: FLNC	Ensembl:ENSG00000128591	euGenes: HUgn2318
ECgene: FLNC	H-InvDB: FLNC

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=FLNC

Licensable Technologies for FLNC
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for FLNC:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FLNC-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FLNC		Antibodies for FLNC
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for FLNC		Browse small molecules at Sigma-Aldrich
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	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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	Recombinant Proteins (FLNC)
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	Custom Service for Rabbit Pab from Full-length Protein

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Antibodies for FLNC

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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FLNC Gene at Home site.
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FLNC Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for FLNC

Summaries
for FLNC

Genomic Location
for FLNC

Proteins
for FLNC

Protein Domains/
Families
for FLNC

Gene Function
for FLNC

Pathways & Interactions
for FLNC

Drugs & Compounds
for FLNC

Transcripts
for FLNC

Expression
for FLNC

Orthologs
for FLNC

Paralogs
for FLNC

SNPs/Variants
for FLNC

Disorders & Mutations
for FLNC

Medical News
for FLNC

Publications
for FLNC

Search for FLNC

Genome Databases showing FLNC

Other Databases showing FLNC

Specialized Databases showing FLNC

Licensable Technologies
for FLNC

Services
for FLNC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FLNC Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor FLNC

Summariesfor FLNC

Genomic Locationfor FLNC

Proteinsfor FLNC

Protein Domains/Familiesfor FLNC

Gene Functionfor FLNC

Pathways & Interactionsfor FLNC

Drugs & Compoundsfor FLNC

Transcriptsfor FLNC

Expression for FLNC

Orthologsfor FLNC

Paralogsfor FLNC

SNPs/Variantsfor FLNC

Disorders & Mutationsfor FLNC

Medical Newsfor FLNC

Publicationsfor FLNC

Search for FLNC

Genome Databases showing FLNC

Other Databases showing FLNC

Specialized Databases showing FLNC

Licensable Technologiesfor FLNC

Servicesfor FLNC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FLNC

Summaries
for FLNC

Genomic Location
for FLNC

Proteins
for FLNC

Protein Domains/
Families
for FLNC

Gene Function
for FLNC

Pathways & Interactions
for FLNC

Drugs & Compounds
for FLNC

Transcripts
for FLNC

Expression
for FLNC

Orthologs
for FLNC

Paralogs
for FLNC

SNPs/Variants
for FLNC

Disorders & Mutations
for FLNC

Medical News
for FLNC

Publications
for FLNC

Licensable Technologies
for FLNC

Services
for FLNC