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FLNA Gene

protein-coding   GIFtS: 69
GCID: GC0XM153576

Filamin A, Alpha

(Previous names: filamin A, alpha (actin binding protein 280))
(Previous symbols: FLN1, FLN, OPD2, OPD1)
  See FLNA-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Filamin A, Alpha1 2     NHBP2 5
FLN11 2 3 5     Filamin A, Alpha (Actin Binding Protein 280)1
FLN1 2 3     ABPX2
OPD11 2 5     OPD2
OPD21 2 5     XLVD2
Actin Binding Protein 2801 2     XMVD2
Endothelial Actin-Binding Protein2 3     alpha-filamin2
Non-Muscle Filamin2 3     filamin-12
ABP-2802 3     filamin-A2
FLN-A2 3     Alpha-filamin3
CSBS2 5     Filamin-13
CVD12 5     Actin-Binding Protein 2803
FMD2 5     EC 2.1.1.438
MNS2 5     EC 6.3.4.48

External Ids:    HGNC: 37541   Entrez Gene: 23162   Ensembl: ENSG000001969247   OMIM: 3000175   UniProtKB: P213333   

Export aliases for FLNA gene to outside databases

Previous GC identifers: GC0XM147640 GC0XM149957 GC0XM151162 GC0XM152044 GC0XM153097 GC0XM153230 GC0XM142154


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FLNA Gene:
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin
filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect
changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and
second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular
heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD),
Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two
transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq, Mar 2009)

GeneCards Summary for FLNA Gene:
FLNA (filamin A, alpha) is a protein-coding gene. Diseases associated with FLNA include heterotopia, periventricular, ed variant, and x-linked periventricular heterotopia. GO annotations related to this gene include protein homodimerization activity and signal transducer activity. An important paralog of this gene is FLNB.

UniProtKB/Swiss-Prot: FLNA_HUMAN, P21333
Function: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins.
Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of
cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone
into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs
its intracellular trafficking (By similarity). Involved in ciliogenesis

Gene Wiki entry for FLNA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011681.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the FLNA gene promoter:
         AP-2alpha isoform 3   AP-1   AP-2alpha isoform 2   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): FLNA promoter sequence
   Search Chromatin IP Primers for FLNA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FLNA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

FLNA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FLNA gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM153576:  view genomic region     (about GC identifiers)

Start:
153,576,892 bp from pter      End:
153,603,006 bp from pter
Size:
26,115 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FLNA_HUMAN, P21333 (See protein sequence)
Recommended Name: Filamin-A  
Size: 2647 amino acids; 280739 Da
Subunit: Homodimer. Interacts with PDLIM2 (By similarity). Interacts with FCGR1A, FLNB, FURIN, HSPB7, INPPL1,
KCND2, MYOT, MYOZ1, ARHGAP24, PSEN1, PSEN2 and ECSCR. Interacts also with various other binding partners in
addition to filamentous actin. Interacts (via N-terminus) with MIS18BP1 (via N-terminus). Interacts (via
N-terminus) with TAF1B. Interacts with TMEM67 (via C-terminus) and MKS1. Interacts (via actin-binding domain)
with MICALL2 (via CH domain)
Caution: Variant Thr-1764 has been originally associated with periventricular nodular heterotopia
(PubMed:12612583). It has been subsequently reported as a benign polymorphism (PubMed:12612583)
Sequence caution: Sequence=BAC03408.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Selected PDB 3D structures from and Proteopedia for FLNA (see all 16):
2AAV (3D)        2BP3 (3D)        2BRQ (3D)        2J3S (3D)        2JF1 (3D)        2K3T (3D)    
Secondary accessions: E9KL45 Q5HY53 Q5HY55 Q8NF52
Alternative splicing: 2 isoforms:  P21333-1   P21333-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FLNA: NX_P21333

Explore proteomics data for FLNA at MOPED

Post-translational modifications: 

  • Phosphorylation extent changes in response to cell activation1
  • Ubiquitination2 at Lys43, Lys220, Lys367, Lys837, Lys906, Lys916, Lys1019, Lys1824, Lys1964, Lys2217,
                                 Lys2240, Lys2417, Lys2621
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for FLNA (P21333)
     GAGIGPT  ELKVTVK 


    See FLNA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001104026.1  NP_001447.2  

    ENSEMBL proteins: 
     ENSP00000408921   ENSP00000353467   ENSP00000358866   ENSP00000358863   ENSP00000397824  
     ENSP00000405458   ENSP00000398215   ENSP00000416926   ENSP00000358872  
    Reactome Protein details: P21333

    FLNA Human Recombinant Protein Products:

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    Novus Biologicals FLNA Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for FLNA
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for FLNA 

     
    antibodies-online proteins for FLNA (2 products) 

     
    Search antibodies-online for peptides for FLNA

    FLNA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of FLNA
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    Abcam antibodies for FLNA (P21333, O75369)
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    ThermoFisher Antibody for FLNA
    antibodies-online antibodies for FLNA (129 products) 

    FLNA Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for FLNA 
    antibodies-online kits for FLNA (26 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR001298 Filamin/ABP280_rpt
     IPR014756 Ig_E-set
     IPR013783 Ig-like_fold
     IPR001715 CH-domain
     IPR017868 Filamin/ABP280_repeat-like

    Graphical View of Domain Structure for InterPro Entry P21333

    ProtoNet protein and cluster: P21333

    2 Blocks protein domains:
    IPB001589 Actin-binding
    IPB001715 Calponin-like actin-binding


    UniProtKB/Swiss-Prot: FLNA_HUMAN, P21333
    Domain: Comprised of a NH2-terminal actin-binding domain, 24 immunoglobulin-like internally homologous repeats and
    two hinge regions. Repeat 24 and the second hinge domain are important for dimer formation
    Similarity: Belongs to the filamin family
    Similarity: Contains 1 actin-binding domain
    Similarity: Contains 2 CH (calponin-homology) domains
    Similarity: Contains 24 filamin repeats


    Find genes that share domains with FLNA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FLNA_HUMAN, P21333
    Function: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins.
    Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of
    cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone
    into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs
    its intracellular trafficking (By similarity). Involved in ciliogenesis

         Genatlas biochemistry entry for FLNA:
    filamin A,dimeric actin cross-linking phosphoprotein of the peripheral cytoplasm,highly expressed in the
    developing cortex and required for locomotion of many cell types

         Enzyme Numbers (IUBMB): EC 2.1.1.432 EC 6.3.4.42

         Gene Ontology (GO): Selected molecular function terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001948glycoprotein binding IDA1833070
    GO:0003779actin binding ----
    GO:0004871signal transducer activity IMP12761501
    GO:0005080protein kinase C binding IEA--
    GO:0005515protein binding IPI10051605
         
    Find genes that share ontologies with FLNA           About GenesLikeMe


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 4 alleles(MGI details for Flna) (see all 16):
     behavior/neurological  cardiovascular system  craniofacial  digestive/alimentary  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system  mortality/aging 
     nervous system  normal  reproductive system  respiratory system  skeleton 

    Find genes that share phenotypes with FLNA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Flnatm1.2Caw for FLNA

       genOway: Develop your customized and physiologically relevant rodent model for FLNA

    miRNA
    Products:
        
    miRTarBase miRNAs that target FLNA:
    hsa-mir-7-5p (MIRT025777), hsa-mir-16-5p (MIRT051288), hsa-mir-1 (MIRT023757), hsa-mir-193b-3p (MIRT041256), hsa-mir-196a-5p (MIRT048229), hsa-mir-221-3p (MIRT046888), hsa-mir-149-5p (MIRT045578), hsa-mir-92b-3p (MIRT040564), hsa-mir-222-3p (MIRT046811), hsa-mir-23a-3p (MIRT050388), hsa-mir-324-5p (MIRT043054), hsa-mir-200c-3p (MIRT044384), hsa-let-7b-5p (MIRT052184), hsa-mir-378a-3p (MIRT043955), hsa-mir-155-5p (MIRT020648), hsa-mir-484 (MIRT042059), hsa-mir-92a-3p (MIRT049560), hsa-mir-20a-5p (MIRT050582), hsa-mir-615-3p (MIRT039798), hsa-mir-23b-3p (MIRT046250), hsa-mir-331-3p (MIRT043388), hsa-mir-31-5p (MIRT049870)

    Block miRNA regulation of human, mouse, rat FLNA using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate FLNA:
    hsa-miR-185* hsa-miR-125a-3p hsa-miR-1827 hsa-miR-1207-5p hsa-miR-3612 hsa-miR-650
    SwitchGear 3'UTR luciferase reporter plasmidFLNA 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for FLNA
    Predesigned siRNA for gene silencing in human, mouse, rat FLNA

    Gene Editing
    Products:
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    Clone
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    OriGene clones in human, mouse for FLNA (see all 10)
    OriGene ORF clones in mouse, rat for FLNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): FLNA (NM_001456)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FLNA
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FLNA
    Addgene plasmids for FLNA 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for FLNA 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLNA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FLNA_HUMAN, P21333: Cytoplasm, cell cortex. Cytoplasm, cytoskeleton
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    extracellular5
    nucleus5
    cytosol4
    plasma membrane4
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005634nucleus IDA15684392
    GO:0005737cytoplasm IDA--
    GO:0005802trans-Golgi network IEA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with FLNA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FLNA About   (see all 21)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    Focal Adhesion0.65
    2MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    3Cell junction organization
    Cell junction organization0.70
    Cell-extracellular matrix interactions0.00
    Cell-Cell communication0.64
    4Response to elevated platelet cytosolic Ca2+
    Response to elevated platelet cytosolic Ca2+0.94
    Platelet degranulation0.94
    5Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43


    Find genes that share SuperPaths with FLNA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FLNA
        SMAD Signaling Network
    ILK Signaling
    Antioxidant Action of Vitamin-C

    1 Cell Signaling Technology (CST) Pathway for FLNA
        Cytoskeletal Signaling

    Selected GeneGo (Thomson Reuters) Pathways for FLNA (see all 6)
        Cytoskeleton remodeling Integrin outside-in signaling
    wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Regulation of CFTR activity (norm and CF)
    wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)

    Selected BioSystems Pathways for FLNA (see all 7)
        MAPK signaling pathway
    Focal Adhesion
    Androgen receptor signaling pathway
    TNF-alpha/NF-kB Signaling Pathway
    Prolactin Signaling Pathway

    3 Reactome Pathways for FLNA
        Cell-extracellular matrix interactions
    Platelet degranulation
    GP1b-IX-V activation signalling


    4 Kegg Pathways  (Kegg details for FLNA):
        MAPK signaling pathway
    Focal adhesion
    Salmonella infection
    Proteoglycans in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FLNA: 
              Neurogenesis in human mouse rat
              Adherens Junctions in human mouse rat
              Focal Adhesions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FLNA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FLNA (P213331, 2, 3 ENSP000003588664) via UniProtKB, MINT, STRING, and/or I2D (see all 204)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGB7P260101, 2, 3, ENSP000002670824EBI-350432,EBI-702932 MINT-51374 MINT-5226955 MINT-5226910 MINT-5226942 MINT-5226916 MINT-5226895 MINT-5226997 I2D: score=4 STRING: ENSP00000267082
    CCNB2O950671, 2, 3, ENSP000002882074EBI-350432,EBI-375024 MINT-4653303 MINT-4653263 MINT-4653380 MINT-4653285 MINT-4653339 MINT-4653322 MINT-4653401 MINT-4653361 I2D: score=1 STRING: ENSP00000288207
    ITGB1P055561, 2, 3, ENSP000003640944EBI-350432,EBI-703066 MINT-5226973 MINT-51379 MINT-5227032 MINT-51375 I2D: score=3 STRING: ENSP00000364094
    ABL1P005192, 3, ENSP000003614234MINT-8110359 I2D: score=3 STRING: ENSP00000361423
    PLCG1P191742, 3, ENSP000002440074MINT-8112543 I2D: score=3 STRING: ENSP00000244007
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001837epithelial to mesenchymal transition IEA--
    GO:0002576platelet degranulation TAS--
    GO:0007195adenylate cyclase-inhibiting dopamine receptor signaling pathway IMP10692483
    GO:0007596blood coagulation TAS--
    GO:0030036actin cytoskeleton organization ----

    Find genes that share ontologies with FLNA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FLNA

    10 Novoseek inferred chemical compound relationships for FLNA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 32.9 9 15566962 (2), 12791664 (2), 12734206 (1), 16849481 (1) (see all 5)
    cytochalasin d 26.1 2 12734206 (1), 9430714 (1)
    alanine 15.8 1 15574123 (1)
    serine 5.61 2 9430714 (1), 10692483 (1)
    oligonucleotide 0 1 16797880 (1)
    phenylalanine 0 1 17431908 (1)
    lipid 0 6 11482904 (2), 15566962 (1), 17060905 (1), 12734206 (1) (see all 5)
    calcium 0 7 10658206 (1), 15837785 (1), 19177143 (1)
    guanine 0 6 16320251 (1), 18996916 (1), 19120042 (1)
    dopamine 0 2 11320256 (2)



    Find genes that share compounds with FLNA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FLNA gene (2 alternative transcripts): 
    NM_001110556.1  NM_001456.3  

    Unigene Cluster for FLNA:

    Filamin A, alpha
    Hs.195464  [show with all ESTs]
    Unigene Representative Sequence: NM_001110556
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000420627(uc011mzn.1) ENST00000360319 ENST00000498411 ENST00000490936
    ENST00000369850 ENST00000344736 ENST00000498491 ENST00000462590 ENST00000444578
    ENST00000474358 ENST00000466325 ENST00000415241 ENST00000438732 ENST00000474072
    ENST00000466319 ENST00000465144 ENST00000422373(uc004fkk.2 uc010nuu.1)
    ENST00000369856
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate FLNA:
    hsa-miR-185* hsa-miR-125a-3p hsa-miR-1827 hsa-miR-1207-5p hsa-miR-3612 hsa-miR-650
    SwitchGear 3'UTR luciferase reporter plasmidFLNA 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FLNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FLNA (NM_001456)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FLNA
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FLNA
    Addgene plasmids for FLNA 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for FLNA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FLNA
      QuantiTect SYBR Green Assays in human, mouse, rat FLNA
      QuantiFast Probe-based Assays in human, mouse, rat FLNA

    Additional mRNA sequence: 

    AB191259.1 AB191260.1 AB371574.1 AB371575.1 AB371576.1 AB371577.1 AB371578.1 AB371579.1 
    AB593010.1 AK074048.1 AK090427.2 AK300165.1 AK304255.1 AL050396.1 AL157419.1 BC014654.1 
    BC028089.1 BC041179.1 BC067111.1 BC109289.1 EF212281.1 GU727643.1 X53416.1 

    Selected DOTS entries (see all 66):

    DT.91982411  DT.95298941  DT.91724551  DT.100671885  DT.450890  DT.91982387  DT.100671880  DT.91982791 
    DT.121294094  DT.91982601  DT.95369157  DT.121293747  DT.121294182  DT.92033161  DT.98083413  DT.100671893 
    DT.121293852  DT.121294208  DT.91982328  DT.97786031  DT.91979279  DT.121294497  DT.95369177  DT.91982036 

    Selected AceView cDNA sequences (see all 158):

    BP354105 AI902801 BP363321 BF734671 CK430947 BU154671 CA397971 CD676237 
    BP354440 BP363238 CD675561 CN483495 CN483857 BP364608 BP364880 BP354093 
    BP365171 BF813169 BP363350 BF912773 BF846254 AL080016 BE900305 BM148611 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FLNA (see all 13)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21b ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34a · 34b ^ 35 ^ 36 ^ 37 ^ 38a · 38b ^ 39 ^ 40a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                -                                                                           
    SP3:                                                                                -                                                                           
    SP4:                                                        -     -     -     -     -                                                                           
    SP5:                                                                                -           -                                                               

    ExUns: 40b ^ 41 ^ 42a · 42b ^ 43a · 43b ^ 44 ^ 45 ^ 46a · 46b ^ 47 ^ 48 ^ 49a · 49b ^ 50
    SP1:  -                 -                 -                                                   
    SP2:  -                 -                 -                                                   
    SP3:  -                 -                                                                     
    SP4:  -                 -                                                                     
    SP5:                                                                                          


    ECgene alternative splicing isoforms for FLNA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FLNA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCAAGGAC
    FLNA Expression
    About this image

    FLNA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FLNA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.195464

    UniProtKB/Swiss-Prot: FLNA_HUMAN, P21333
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FLNA: 
              Neurogenesis in human mouse rat
              Adherens Junctions in human mouse rat
              Focal Adhesions in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FLNA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FLNA
    QuantiTect SYBR Green Assays in human, mouse, rat FLNA
    QuantiFast Probe-based Assays in human, mouse, rat FLNA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLNA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FLNA gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Flna1 , 5 filamin, alpha1, 5 87.33(n)1
    97.31(a)1
      X (37.89 cM)5
    1921761  NM_010227.21  NP_034357.21 
     742234615 
    chicken
    (Gallus gallus)
    Aves FLNA1 filamin A, alpha 74.01(n)
    76.36(a)
      395261  NM_204574.1  NP_989905.1 
    lizard
    (Anolis carolinensis)
    Reptilia FLNA6
    filamin A, alpha
    85(a)
    1 ↔ 1
    2(87690245-87796658)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.37232 Transcribed sequence with moderate similarity to protein more 78.67(n)    AL847431.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb98b062 Transcribed sequence with moderate similarity to protein more 84.91(n)    CA471662.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cher1 , 3 actin binding3
    cheerio1
    53(a)
    (best of 2)3
    52.19(n)1
    42.91(a)1
      420661  NM_001275729.11  NP_001262658.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C23F12.23
    fln-11
    actin-binding3
    fln-11
    41(a)
    (best of 3)3
    44.82(n)1
    36.58(a)1
      X(9432989-9443298)3
    1768551  NM_001028379.31  NP_001023550.21 


    ENSEMBL Gene Tree for FLNA (if available)
    TreeFam Gene Tree for FLNA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FLNA gene
    FLNB2  FLNC2  
    12 SIMAP similar genes for FLNA using alignment to 12 protein entries:     FLNA_HUMAN (see all proteins):
    FLJ00119    LOC392787    DKFZp686A1668    FLNB    FLNC    CLMN
    PLEC    MACF1    HSpTB1    ACTN1    DMD    DST

    Find genes that share paralogs with FLNA           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for FLNA
    PGOHUM00000239781


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FLNA (see all 788)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs289354731,2,,4
    CMelnick-Needles syndrome (MNS)4 pathogenic1153456826(-) CTGCTC/TGGAGG 4 S L mis1 ese30--------
    rs289354721,2,,4
    CMelnick-Needles syndrome (MNS)4 pathogenic1153456860(-) CGAGCA/GCGGGC 4 T A mis1 ese30--------
    rs289354711,2,,4
    CFrontometaphyseal dysplasia (FMD)4 pathogenic1153456946(-) CTTTGA/CCGCAT 4 D A mis1 ese30--------
    rs1438739381,2,,4
    CPeriventricular nodular heterotopia 1 (PVNH1)4 --153461872(+) CTTCAC/TGCGCT 4 M V mis10--------
    rs289354701,2,,4
    COtopalatodigital syndrome 2 (OPD2)4 pathogenic1153464132(-) TGGACA/GAGCAC 4 K E mis1 ese30--------
    rs289351691,2,,4
    CPeriventricular nodular heterotopia 1 (PVNH1)4 pathogenic1153467628(-) GTTGGA/TGGTGC 4 E V mis1 ese30--------
    VAR_0157234
    Otopalatodigital syndrome 2 (OPD2)4--see VAR_0157232 C F mis40--------
    VAR_0157154
    Otopalatodigital syndrome 2 (OPD2)4--see VAR_0157152 R G mis40--------
    VAR_0157164
    Otopalatodigital syndrome 1 (OPD1)4--see VAR_0157162 R W mis40--------
    VAR_0641574
    Cardiac valvular dysplasia X-linked (CVDX)4--see VAR_0641572 P Q mis40--------

    HapMap Linkage Disequilibrium report for FLNA (153576892 - 153603006 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for FLNA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508002CNV Insertion20534489
    nsv519042CNV Gain19592680
    nsv9999CNV Gain18304495
    esv33199CNV Gain+Loss17666407
    esv33784CNV Gain+Loss17666407
    nsv7468OTHER Inversion18451855
    dgv65n47OTHER Inversion21111241
    nsv219OTHER Inversion15895083

    Human Gene Mutation Database (HGMD): FLNA
    Locus Specific Mutation Databases (LSDB): FLNA

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FLNA
    DNA2.0 Custom Variant and Variant Library Synthesis for FLNA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 300017   
    OMIM disorders: 300049  311300  304120  300048  309350  305620  300537  300321  314400  300244  
    UniProtKB/Swiss-Prot: FLNA_HUMAN, P21333
  • Periventricular nodular heterotopia 1 (PVNH1) [MIM:300049]: A developmental disorder characterized by the
    presence of periventricular nodules of cerebral gray matter, resulting from a failure of neurons to migrate
    normally from the lateral ventricular proliferative zone, where they are formed, to the cerebral cortex. PVNH1 is
    an X-linked dominant form. Heterozygous females have normal intelligence but suffer from seizures and various
    manifestations outside the central nervous system, especially related to the vascular system. Hemizygous affected
    males die in the prenatal or perinatal period. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Periventricular nodular heterotopia 4 (PVNH4) [MIM:300537]: A disorder characterized by nodular brain
    heterotopia, joint hypermobility and development of aortic dilation in early adulthood. Note=The disease is
    caused by mutations affecting the gene represented in this entry
  • Otopalatodigital syndrome 1 (OPD1) [MIM:311300]: X-linked dominant multiple congenital anomalies disease
    mainly characterized by a generalized skeletal dysplasia, mild mental retardation, hearing loss, cleft palate,
    and typical facial anomalies. OPD1 belongs to a group of X-linked skeletal dysplasias known as oto-palato-digital
    syndrome spectrum disorders that also include OPD2, Melnick-Needles syndrome (MNS), and frontometaphyseal
    dysplasia (FMD). Remodeling of the cytoskeleton is central to the modulation of cell shape and migration. FLNA is
    a widely expressed protein that regulates re-organization of the actin cytoskeleton by interacting with
    integrins, transmembrane receptor complexes and second messengers. Males with OPD1 have cleft palate,
    malformations of the ossicles causing deafness and milder bone and limb defects than those associated with OPD2.
    Obligate female carriers of mutations causing both OPD1 and OPD2 have variable (often milder) expression of a
    similar phenotypic spectrum. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Otopalatodigital syndrome 2 (OPD2) [MIM:304120]: Congenital bone disorder that is characterized by
    abnormally modeled, bowed bones, small or absent first digits and, more variably, cleft palate, posterior fossa
    brain anomalies, omphalocele and cardiac defects. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Frontometaphyseal dysplasia (FMD) [MIM:305620]: Congenital bone disease characterized by supraorbital
    hyperostosis, deafness and digital anomalies. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Melnick-Needles syndrome (MNS) [MIM:309350]: Severe congenital bone disorder characterized by typical
    facies (exophthalmos, full cheeks, micrognathia and malalignment of teeth), flaring of the metaphyses of long
    bones, s-like curvature of bones of legs, irregular constrictions in the ribs, and sclerosis of base of skull.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Intestinal pseudoobstruction, neuronal, chronic idiopathic, X-linked (IPOX) [MIM:300048]: A disease
    characterized by a severe abnormality of gastrointestinal motility due to primary qualitative defects of enteric
    ganglia and nerve fibers. Affected individuals manifest recurrent signs of intestinal obstruction in the absence
    of any mechanical lesion. Note=The disease is caused by mutations affecting the gene represented in this entry
  • FG syndrome 2 (FGS2) [MIM:300321]: FG syndrome (FGS) is an X-linked disorder characterized by mental
    retardation, relative macrocephaly, hypotonia and constipation. Note=The disease is caused by mutations affecting
    the gene represented in this entry
  • Terminal osseous dysplasia (TOD) [MIM:300244]: A rare X-linked dominant male-lethal disease characterized
    by skeletal dysplasia of the limbs, pigmentary defects of the skin and recurrent digital fibroma during infancy.
    A significant phenotypic variability is observed in affected females. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • Cardiac valvular dysplasia X-linked (CVDX) [MIM:314400]: A rare X-linked heart disease characterized by
    mitral and/or aortic valve regurgitation. The histologic features include fragmentation of collagenous bundles
    within the valve fibrosa and accumulation of proteoglycans, which produces excessive valve tissue leading to
    billowing of the valve leaflets. Note=The disease is caused by mutations affecting the gene represented in this
    entry
  • Note=Defects in FLNA may be a cause of macrothrombocytopenia, a disorder characterized by subnormal
    levels of blood platelets. Blood platelets are abnormally enlarged
  • Congenital short bowel syndrome, X-linked (CSBSX) [MIM:300048]: A disease characterized by a shortened
    small intestine, and malabsorption. The mean length of the small intestine in affected individuals is
    approximately 50 cm, compared with a normal length at birth of 190-280 cm. It is associated with significant
    mortality and morbidity. Infants usually present with failure to thrive, recurrent vomiting, and diarrhea.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for FLNA (see all 29):    
    About MalaCards
    heterotopia, periventricular, ed variant    x-linked periventricular heterotopia    periventricular nodular heterotopia    periventricular heterotopia, ehlers-danlos variant
    oto-palato-digital syndrome type 1    fg syndrome 2    melnick-needles syndrome    terminal osseous dysplasia
    intestinal pseudoobstruction neuronal chronic idiopathic x-linked    intestinal pseudo-obstruction    flna-related disorders    otopalatodigital spectrum disorders
    periventricular heterotopia    locked-in syndrome    cardiac valvular dysplasia, x-linked    frontometaphyseal dysplasia
    amniotic band syndrome    flna-related x-linked cardiac valvular dysplasia    oto-palato-digital syndrome type 2    intestinal pseudoobstruction, neuronal

    6 diseases from the University of Copenhagen DISEASES database for FLNA:
    Periventricular nodular heterotopia     Astigmatism     Schizotypal personality disorder     Borderline personality disorder
    Lissencephaly     Aicardi syndrome

    Find genes that share disorders with FLNA           About GenesLikeMe

    Selected Novoseek inferred disease relationships for FLNA gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    periventricular nodular heterotopia 97 44 15249610 (4), 15459826 (2), 16684786 (2), 14988809 (2) (see all 25)
    frontometaphyseal dysplasia 92.3 6 17431908 (1), 12612583 (1), 14988809 (1), 16596676 (1) (see all 5)
    melnick-needles syndrome 86 3 20186808 (1), 12612583 (1), 17159511 (1)
    infantile spasms 65.4 4 16417552 (3)
    skeletal dysplasia 63.1 5 16538226 (1), 19773341 (1), 14988809 (1), 16596676 (1)
    melanoma 54.1 44 19213840 (3), 19177143 (3), 11706047 (2), 18404377 (2) (see all 25)
    ehlers-danlos syndrome 53.1 2 15668422 (1), 15994863 (1)
    skeletal disorder 50.9 3 15684392 (1), 19805437 (1)
    epilepsy 49.2 5 15459826 (1), 10477759 (1), 11914408 (1), 16684786 (1) (see all 5)
    mild mental retardation 44.2 1 11914408 (1)

    GeneTests: FLNA
    GeneReviews: FLNA
    Genetic Association Database (GAD): FLNA
    Human Genome Epidemiology (HuGE) Navigator: FLNA (5 documents)

    Export disorders for FLNA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FLNA gene, integrated from 10 sources (see all 391):
    (articles sorted by number of sources associating them with FLNA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Localized mutations in the gene encoding the cytoskeletal protein filamin A cause diverse malformations in humans. (PubMed id 12612583)1, 2, 3, 9 Robertson S.P.... Wilkie A.O.M. (Nat. Genet. 2003)
    2. Mutations in the X-linked filamin 1 gene cause periventricular nodular heterotopia in males as well as in females. (PubMed id 11532987)1, 2, 9 Sheen V.L.... Walsh C.A. (Hum. Mol. Genet. 2001)
    3. Filamin A and filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact. (PubMed id 12393796)1, 2, 9 Sheen V.L.... Walsh C.A. (Hum. Mol. Genet. 2002)
    4. Mutations in the gene encoding filamin A as a cause for familial cardiac valvular dystrophy. (PubMed id 17190868)1, 2, 9 Kyndt F....Schott J.J. (Circulation 2007)
    5. Filamin A mutations cause periventricular heterotopia with Ehlers- Danlos syndrome. (PubMed id 15668422)1, 2, 9 Sheen V.L.... Walsh C.A. (Neurology 2005)
    6. Ehlers-Danlos syndrome and periventricular nodular heterotopia in a Spanish family with a single FLNA mutation. (PubMed id 15994863)1, 2, 9 Gomez-Garre P....Serratosa J.M. (J. Med. Genet. 2006)
    7. Mapping of two genes encoding isoforms of the actin binding protein ABP-280, a dystrophin like protein, to Xq28 and to chromosome 7. (PubMed id 7689010)1, 2, 9 Maestrini E.... Toniolo D. (Hum. Mol. Genet. 1993)
    8. Genotype-epigenotype-phenotype correlations in females with frontometaphyseal dysplasia. (PubMed id 16596676)1, 2, 9 Zenker M.... Horn D. (Am. J. Med. Genet. A 2006)
    9. Germline and mosaic mutations of FLN1 in men with periventricular heterotopia. (PubMed id 15249610)1, 2, 9 Guerrini R.... Parrini E. (Neurology 2004)
    10. Actin-binding protein (ABP-280) filamin gene (FLN) maps telomeric to the color vision locus (R/GCP) and centromeric to G6PD in Xq28. (PubMed id 8406501)1, 3, 9 Gorlin J.B....Kwiatkowski D.J. (Genomics 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2316 HGNC: 3754 AceView: FLNA Ensembl:ENSG00000196924 euGenes: HUgn2316
    ECgene: FLNA Kegg: 2316 H-InvDB: FLNA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FLNA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FLNA Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=FLNA[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FLNA gene:
    Search GeneIP for patents involving FLNA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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