Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FLII Gene

protein-coding GIFtS: 57
GCID: GC17M018148

flightless I homolog (Drosophila)

(Previous name: flightless I (Drosophila) homolog )

Explore 11 diseases affiliated with
FLII via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Flightless I Homolog (Drosophila)¹ ²		MGC39265¹
FLIL¹ ² ³		Flightless I (Drosophila) Homolog¹
FLI¹ ²		Protein Flightless-1 Homolog²
Fli1¹ ²

External Ids:	HGNC: 3750¹	Entrez Gene: 2314²	Ensembl: ENSG00000177731⁷	OMIM: 600362⁵	UniProtKB: Q13045³

Export aliases for FLII gene to outside databases

Previous GC identifers: GC17M018393 GC17M019740 GC17M018091 GC17M018348 GC17M018088 GC17M017901

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FLII:

This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein

protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the

structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on

chromosome 17. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FLII_HUMAN, Q13045

Function: May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and

acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic

development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and

cell migration, by inhibiting Rac1-dependent paxillin phosphorylation

Gene Wiki entry for FLII

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010718.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FLII gene promoter:
RP58 USF1 p53 SREBP-1c SREBP-1b Evi-1 HEN1 SREBP-1a USF-1 Msx-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FLII promoter sequence

Search SABiosciences Chromatin IP Primers for FLII

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FLII

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2 Ensembl cytogenetic band: 17p11.2 HGNC cytogenetic band: 17p11.2

FLII Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FLII gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M018148: view genomic region (about GC identifiers)

Start:	18,148,150 bp from pter	End:	18,162,230 bp from pter
Size:	14,081 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FLII_HUMAN, Q13045 (See protein sequence)

Recommended Name: Protein flightless-1 homolog

Size: 1269 amino acids; 144751 Da

Subunit: Interacts with actin, ACTL6A, NCOA2, CARM1 and MYD88. Interacts with LRRFIP1 and LRRFIP2. Upon LPS

stimulation, LRRFIP2 competes for MYD88-binding. LRRFIP1 constitutively blocks the interaction with MyD88, even in the

absence of LPS. Interacts with the nuclear receptors ESR1 and THRB. Interacts with SGK3

Subcellular location: Nucleus (By similarity). Cytoplasm, cytoskeleton (By similarity). Cytoplasm, cytoskeleton,

centrosome (By similarity). Cell junction, focal adhesion (By similarity). Note=Colocalizes to actin-rich structures

in blastocysts and, together with HRAS1, RHOA and CDC42, in migrating fibroblasts. Localizes to centrosomes (By

similarity)

Secondary accessions: B4DIL0 F5H407

Alternative splicing: 2 isoforms: Q13045-1 Q13045-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FLII: NX_Q13045

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q13045

FLII Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001243193.1 NP_001243194.1 NP_002009.1

ENSEMBL proteins:

ENSP00000465202 ENSP00000468045 ENSP00000462314 ENSP00000324573 ENSP00000438536

ENSP00000462293 ENSP00000463534 ENSP00000463675 ENSP00000463838 ENSP00000463902

ENSP00000462797 ENSP00000467199 ENSP00000467212 ENSP00000368763

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: FLII OriGene Custom Protein Services for FLII
	GenScript Custom Purified and Recombinant Proteins Services for FLII
	Novus Biologicals FLII Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for FLII

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005813	centrosome	IDA	--
GO:0005925	focal adhesion	IEA	--

FLII for ontologies About GeneDecksing

FLII Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 2): FLII OriGene Custom Antibody Services for FLII
	GenScript Custom Superior Antibodies Services for FLII
	Novus Biologicals FLII Antibodies
	Abcam antibodies for FLII
	Uscn Antibodies for FLII
	ThermoFisher Antibody for FLII

Assay Products for FLII:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for FLII
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FLII

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FLII for domains About GeneDecksing

5 InterPro domains/families:

IPR001611 Leu-rich_rpt

IPR025875 Leu-rich_rpt_4

IPR007122 Gelsolin

IPR003591 Leu-rich_rpt_typical-subtyp

IPR007123 Gelsolin_dom

Graphical View of Domain Structure for InterPro Entry Q13045

ProtoNet protein and cluster: Q13045

2 Blocks protein families:

IPB001611 Leucine-rich repeat signature

IPB007123 Gelsolin region

UniProtKB/Swiss-Prot: FLII_HUMAN, Q13045

Similarity: Contains 5 gelsolin-like repeats

Similarity: Contains 15 LRR (leucine-rich) repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FLII_HUMAN, Q13045

Function: May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and

acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic

development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and

cell migration, by inhibiting Rac1-dependent paxillin phosphorylation

Genatlas biochemistry entry for FLII:

Drosophila flightless (fli) homolog 1,highly expressed in muscle,overlapping 3'end of LLGL1,constantly deleted in

Smith-Magenis syndrome (SMCR),member of gelsolin and LRR family

miRNA Products:		OriGene 3'-UTR Clone: FLII Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FLII
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate FLII:
		hsa-miR-3675-3p hsa-miR-889 hsa-miR-3647-3p
		SwitchGear 3'UTR luciferase reporter plasmid: FLII 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FLII (see all 4) OriGene shRNA RFP: FLII OriGene siRNA: FLII
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FLII

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for FLII

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FLII (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FLII OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FLII (NM_002018)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FLII
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLII

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FLII
		Search LifeMap BioReagents cell lines for FLII

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLII

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--
GO:0005515	protein binding	IPI	10366446

FLII for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for FLII:

Decreased p24 protein expressi

Animal Models:
Mouse knock-out Flii^tm1Hdc for FLII
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Flii):

embryogenesis

homeostasis/metabolism

mortality/aging

FLII for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FLII

STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

5/26 Interacting proteins for FLII (Q13045^{1, 2, 3} ENSP00000324573⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 26)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LRRFIP1	Q32MZ4¹^,³, ENSP00000375857⁴	EBI-351549,EBI-1369100 I2D: score=3 STRING: ENSP00000375857
LRRFIP2	Q9Y608³, ENSP00000338727⁴	I2D: score=3 STRING: ENSP00000338727
ACTB	P60709³, ENSP00000349960⁴	I2D: score=1 STRING: ENSP00000349960
ACTL6A	O96019³, ENSP00000397552⁴	I2D: score=2 STRING: ENSP00000397552
MYD88	Q99836³, ENSP00000379625⁴	I2D: score=4 STRING: ENSP00000379625

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006936	muscle contraction	TAS	9177775
GO:0007275	multicellular organismal development	IEA	--

FLII for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FLII for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FLII
1 Novoseek chemical compound relationship for FLII gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
atp	7.74	7	11580247 (3), 16780875 (2), 10998179 (1)

Search CenterWatch for drugs/clinical trials and news about FLII

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FLII gene (3 alternative transcripts):

NM_001256264.1 NM_001256265.1 NM_002018.3

Unigene Cluster for FLII:

Flightless I homolog (Drosophila)

Hs.513984 [show with all ESTs]

Unigene Representative Sequence: NM_002018

18/31 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31):

ENST00000581858 ENST00000577398 ENST00000578558 ENST00000327031(uc002gsq.1 uc002gsr.1 uc010vxn.1 uc010vxo.1 uc002gss.1)

ENST00000545457 ENST00000578101 ENST00000579294 ENST00000465046 ENST00000493600

ENST00000487693 ENST00000487369 ENST00000474265 ENST00000577485 ENST00000493401

ENST00000476369 ENST00000580966 ENST00000580453 ENST00000459958

miRNA Products:		OriGene 3'-UTR Clone: FLII Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FLII
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate FLII:
		hsa-miR-3675-3p hsa-miR-889 hsa-miR-3647-3p
		SwitchGear 3'UTR luciferase reporter plasmid: FLII 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FLII (see all 4) OriGene shRNA RFP: FLII OriGene siRNA: FLII
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FLII

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FLII (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FLII OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FLII (NM_002018)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FLII
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLII

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FLII Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FLII
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FLII
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FLII

Additional cDNA sequence:

AB208864.1 AK295655.1 AK295814.1 AK297836.1 AK310400.1 BC001582.1 BC017030.2 BC021885.1

BC025300.1 U01184.1

24/28 DOTS entries (see all 28):

DT.75169954 DT.95291769 DT.100843196 DT.95355701 DT.100843193 DT.95355238 DT.40117375 DT.100844998

DT.95355263 DT.100843188 DT.120997771 DT.100031398 DT.95355372 DT.95355377 DT.100031403 DT.95337867

DT.102834873 DT.120997717 DT.120997768 DT.91692009 DT.100843192 DT.95322594 DT.95355241 DT.95355374

24/573 AceView cDNA sequences (see all 573):

BG110593 AI401124 BE244601 BG251442 BU619788 BE906397 CA428717 BG254987

BM091152 AW000787 AI990472 BM914881 AI138835 BE348406 BI824801 BE311918

BC025300 BU553184 BQ632289 BU173859 CA307088 BU944115 BQ939283 BF001638

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for FLII (see all 16) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	·	8c	·	8d	^	9a	·	9b	·	9c	^	10	^	11a	·	11b	^	12	^	13	^	14a	·	14b	^	15	^	16	^	17	^
SP1:
SP2:
SP3:											-
SP4:
SP5:																															-		-		-		-		-		-		-		-		-		-		-

ExUns:	18a	·	18b	^	19a	·	19b	^	20	^	21a	·	21b	^	22	^	23	^	24a	·	24b	^	25a	·	25b	·	25c	^	26a	·	26b	^	27a	·	27b	·	27c	^	28	^	29a	·	29b	^	30	^	31a	·	31b	^	32a	·
SP1:	-										-
SP2:																											-																-
SP3:
SP4:
SP5:	-		-		-						-

ECgene alternative splicing isoforms for FLII

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FLII expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCGGCCGCG

About this image
See FLII Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FLII

SOURCE GeneReport for Unigene cluster: Hs.513984

UniProtKB/Swiss-Prot: FLII_HUMAN, Q13045

Tissue specificity: Strongest expression in skeletal muscle with high expression also in the heart and lung

SABiosciences Custom PCR Arrays for FLII

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FLII Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FLII
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FLII
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FLII

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLII

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for FLII gene from 7/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FLII¹	flightless I homolog (Drosophila)	83.07(n) 88.11(a)		416515 NM_001030635.1 NP_001025806.1
lizard (Anolis carolinensis)	Reptilia	FLII⁶	--	85(a)	1 ↔ 1	GL343618.1(132672-165850)
zebrafish (Danio rerio)	Actinopterygii	flii¹	flightless I homolog (Drosophila)	74.27(n) 84.03(a)		560281 XM_683678.5 XP_688770.1
fruit fly (Drosophila melanogaster)	Insecta	fliI^{1 , 3}	actin binding³ flightless I¹	56(a)³ 62.14(n)¹ 58.37(a)¹		19F5³ 33110¹ NM_080358.2¹ NP_525097.1¹
worm (Caenorhabditis elegans)	Secernentea	sup-5³ fli-1¹	Protein FLI-1¹	49(a)³ 51.96(n)¹ 52.37(a)¹		III(8747816-8755414)³ 176215¹ NM_066512.4¹ NP_498913.2¹
thale cress (Arabidopsis thaliana)	eudicotyledons	VLN5⁶ VLN3⁶ (see all 5)	villin 3 (see all 5)	20(a) 20(a) (see all 5)	possible ortholog possible ortholog (see all 5)	5(23212690-23217549) 3(21243136-21251100)
rice (Oryza sativa)	Liliopsida	-- -- (see all 5)	villin protein, putative, expressed (see all 5)	25(a) 20(a) (see all 5)	possible ortholog possible ortholog (see all 5)	8(8507453-8515439) 4(30278742-30287878)

ENSEMBL Gene Tree for FLII (if available)
TreeFam Gene Tree for FLII (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FLII gene

SVIL² AVIL² VILL² SCIN² GSN² VIL1² CAPG²

13 SIMAP similar genes for FLII using alignment to 12 protein entries: FLII_HUMAN (see all proteins):

AVIL LRRC8B RSU1 LRRC57 VIL1 GSN

PHLPP1 LRRD1 CAPG LRRC28 SCIN PODNL1

TLR10

FLII for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113978084^1,2	C,	--	17900930(+)	`GCCTCC/ACAAGT`	3	--	ds500¹		1		NA	2
rs73980862^1,2	C,	--	17901477(+)	`GAAGAG/CTGAGG`	3	--	ut3¹		2		WA	120
rs11653817^1,2	C,H	--	17901723(+)	`TTGCAA/GAAGGC`	6	F	syn¹ ese³		1		NA	2
rs74508005^1,2	C,	--	17903199(+)	`CTTTTG/TCAGGC`	6	K Q	mis¹		0	--	--	--	--
rs2605139^1,2	C,H	--	17903901(+)	`GTCCCA/CATTCT`	6	G W	mis¹		4		NS EA	404
rs77629345^1,2	C	--	17906419(-)	`ATGAGC/TCACCG`	3	--	int¹		1		NA	2
rs73289913^1,2	C,	--	17907171(+)	`TGCCCG/AGCTGA`	3	--	int¹		2		WA	120
rs78373492^1,2	F,	--	17908157(+)	`AGCACC/TCCCCG`	3	--	int¹		1		WA	118
rs111622888^1,2	C	--	17908246(+)	`GGCTCT/ACCTCC`	3	--	spd¹		1		CSA	1
rs73289914^1,2	C,	--	17908485(+)	`AAAGCT/CGTATG`	3	--	int¹		2		WA	120

HapMap Linkage Disequilibrium report for FLII (18148150 - 18162230 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FLII
1 CNV: 30807
1 Inversion: 0495

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FLII

DNA2.0 Custom Variant and Variant Library Synthesis for FLII

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FLII for disorders           About GeneDecksing

OMIM gene information: 600362    OMIM disorders: --

11 diseases for FLII:    About MalaCards

smith-magenis syndrome peripheral primitive neuroectodermal tumor primitive neuroectodermal tumor short stature

ewing's family of tumors neuroectodermal tumors brachydactyly angiosarcoma

shigellosis sarcoma blindness

2 diseases from the University of Copenhagen DISEASES database for FLII:

Adamantinoma Peripheral primitive neuroectodermal tumor

2 Novoseek disease relationships for FLII gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ewings sarcoma	51.2	2	10523836 (1), 11313995 (1)
tumors	0	2	9177775 (1), 17409396 (1)

Human Genome Epidemiology (HuGE) Navigator: FLII (4 documents)

Export disorders for FLII gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FLII gene, integrated from 9 sources (see all 72):
(articles sorted by number of sources associating them with FLII)

Utopia: connect your pdf to the dynamic
world of online information

Identification of Flightless-I as a Substrate of the Cytokine-independent Survival Kinase CISK. (PubMed id 19293151)^{1, 2, 9} Xu J....Songyang Z. (2009)
Identification of the binding partners for flightless I, a novel protein bridging the leucine-rich repeat and the gelsolin superfamilies. (PubMed id 9525888)^{1, 2, 9} Liu Y.-T. and Yin H.L. (1998)
Genomic structure, evolution, and expression of human FLII, a gelsolin and leucine-rich-repeat family member: overlap with LLGL. (PubMed id 9177775)^{1, 2, 9} Campbell H.D.... Lupski J.R. (1997)
The human homologue of the Drosophila melanogaster flightless-I gene (flil) maps within the Smith-Magenis microdeletion critical region in 17p11.2. (PubMed id 7825574)^{1, 3, 9} Chen K.S....Lupski J.R. (1995)
Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins. (PubMed id 19265123)^{1, 2} Dai P....Chen X. (2009)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity. (PubMed id 14966289)^{1, 2} Lee Y.-H.... Stallcup M.R. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{1, 2} Gevaert K.... Vandekerckhove J. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2314	HGNC: 3750	AceView: FLII	Ensembl:ENSG00000177731	euGenes: HUgn2314
ECgene: FLII	H-InvDB: FLII

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FLII	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FLII gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FLII gene:
Search GeneIP for patents involving FLII

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for FLII		OriGene shRNA RFP for FLII
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FLII		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FLII
	OriGene Protein Over-expression Lysate for FLII		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for FLII		OriGene 3'-UTR Clone for FLII
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FLII		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FLII
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for FLII		OriGene Custom Protein Services for FLII
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FLII
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FLII
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FLII
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FLII
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FLII
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FLII

	GenScript Custom Purified and Recombinant Proteins Services for FLII		GenScript cDNA clones with any tag delivered in your preferred vector for FLII
	GenScript Custom Assay Services for FLII		GenScript Custom Superior Antibodies Services for FLII
	GenScript Custom overexpressing Cell Line Services for FLII		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in FLII promoter
	Search Chromatin IP Primers for FLII
	RT² qPCR Primer Assay in human, mouse, rat FLII
	GNC Network for FLII
	SABiosciences Custom PCR Arrays for FLII

Search Tocris compounds for FLII

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	FLII antibodies
	FLII lysates

	Antibodies for FLII
	See all of Abcam's Antibodies, Kits and Proteins for FLII
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

FLII Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for FLII

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLII

	SwitchGear 3'UTR luciferase reporter plasmids for FLII
	SwitchGear Promoter luciferase reporter plasmids for FLII

ThermoFisher Antibody for FLII

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FLII

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes FLII gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

FLII Gene

flightless I homolog (Drosophila)

Aliases
for FLII gene

Summaries
for FLII gene

Genomic Views
for FLII gene

Proteins
for FLII gene

Protein Domains /
Families
for FLII gene

Function
for FLII gene

Pathways & Interactions
for FLII gene

Drugs & Compounds
for FLII gene

Transcripts
for FLII gene

Expression
for FLII gene

Orthologs
for FLII gene

Paralogs
for FLII gene

Genomic Variants
for FLII gene

Disorders / Diseases
for FLII gene

Publications
for FLII gene

External Searches for FLII gene

Genome Databases showing FLII gene

Other Databases showing FLII gene

Specialized Databases showing FLII gene

Intellectual Property
for FLII gene

Products
for FLII gene

View Random Gene

Advanced Search

Export list of displayed genes

FLII Gene

flightless I homolog (Drosophila)

Aliasesfor FLII gene

Summariesfor FLII gene

Genomic Viewsfor FLII gene

Proteinsfor FLII gene

Protein Domains /Familiesfor FLII gene

Functionfor FLII gene

Pathways & Interactionsfor FLII gene

Drugs & Compoundsfor FLII gene

Transcriptsfor FLII gene

Expression for FLII gene

Orthologsfor FLII gene

Paralogsfor FLII gene

Genomic Variantsfor FLII gene

Disorders / Diseasesfor FLII gene

Publicationsfor FLII gene

External Searches for FLII gene

Genome Databases showing FLII gene

Other Databases showing FLII gene

Specialized Databases showing FLII gene

Intellectual Propertyfor FLII gene

Productsfor FLII gene

View Random Gene

Aliases
for FLII gene

Summaries
for FLII gene

Genomic Views
for FLII gene

Proteins
for FLII gene

Protein Domains /
Families
for FLII gene

Function
for FLII gene

Pathways & Interactions
for FLII gene

Drugs & Compounds
for FLII gene

Transcripts
for FLII gene

Expression
for FLII gene

Orthologs
for FLII gene

Paralogs
for FLII gene

Genomic Variants
for FLII gene

Disorders / Diseases
for FLII gene

Publications
for FLII gene

Intellectual Property
for FLII gene

Products
for FLII gene