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Aliases for FLII Gene

Aliases for FLII Gene

  • Flightless I Homolog (Drosophila) 2 3
  • FLIL 3 4
  • Flightless I (Drosophila) Homolog 2
  • Protein Flightless-1 Homolog 3
  • Fli1 3
  • FLI 3

External Ids for FLII Gene

Summaries for FLII Gene

Entrez Gene Summary for FLII Gene

  • This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

GeneCards Summary for FLII Gene

FLII (Flightless I Homolog (Drosophila)) is a Protein Coding gene. Diseases associated with FLII include smith-magenis syndrome. GO annotations related to this gene include actin binding. An important paralog of this gene is AVIL.

UniProtKB/Swiss-Prot for FLII Gene

  • May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation.

Gene Wiki entry for FLII Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLII Gene

Genomics for FLII Gene

Genomic Location for FLII Gene

Start:
18,244,815 bp from pter
End:
18,258,916 bp from pter
Size:
14,102 bases
Orientation:
Minus strand

Genomic View for FLII Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FLII Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FLII Gene

Regulatory Elements for FLII Gene

Proteins for FLII Gene

  • Protein details for FLII Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13045-FLII_HUMAN
    Recommended name:
    Protein flightless-1 homolog
    Protein Accession:
    Q13045
    Secondary Accessions:
    • B4DIL0
    • F5H407
    • J3QLG3

    Protein attributes for FLII Gene

    Size:
    1269 amino acids
    Molecular mass:
    144751 Da
    Quaternary structure:
    • Interacts with actin, ACTL6A, NCOA2, CARM1 and MYD88. Interacts with LRRFIP1 and LRRFIP2. Upon LPS stimulation, LRRFIP2 competes for MYD88-binding. LRRFIP1 constitutively blocks the interaction with MyD88, even in the absence of LPS. Interacts with the nuclear receptors ESR1 and THRB. Interacts with SGK3.
    SequenceCaution:
    • Sequence=BAG58522.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FLII Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FLII Gene

Proteomics data for FLII Gene at MOPED

Post-translational modifications for FLII Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys21, Lys730, Lys746, Lys802, Lys832, Lys836, Lys1029, Lys1035, and Lys1162

No data available for DME Specific Peptides for FLII Gene

Domains for FLII Gene

UniProtKB/Swiss-Prot:

FLII_HUMAN
Similarity:
  • Contains 5 gelsolin-like repeats.:
    • Q13045
  • Contains 15 LRR (leucine-rich) repeats.:
    • Q13045
genes like me logo Genes that share domains with FLII: view

No data available for Gene Families for FLII Gene

Function for FLII Gene

Molecular function for FLII Gene

GENATLAS Biochemistry: Drosophila flightless (fli) homolog 1,highly expressed in muscle,overlapping 3end of LLGL1,constantly deleted in Smith-Magenis syndrome (SMCR),member of gelsolin and LRR family
UniProtKB/Swiss-Prot Function: May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation.

Gene Ontology (GO) - Molecular Function for FLII Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 10366446
genes like me logo Genes that share ontologies with FLII: view

Phenotypes for FLII Gene

genes like me logo Genes that share phenotypes with FLII: view

Animal Models for FLII Gene

MGI Knock Outs for FLII:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FLII Gene

Localization for FLII Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLII Gene

Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, focal adhesion. Note=Colocalizes to actin-rich structures in blastocysts and, together with HRAS, RHOA and CDC42, in migrating fibroblasts. Localizes to centrosomes (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FLII Gene COMPARTMENTS Subcellular localization image for FLII gene
Compartment Confidence
cytoskeleton 4
cytosol 4
nucleus 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for FLII Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005815 microtubule organizing center IDA --
GO:0005925 focal adhesion IEA --
genes like me logo Genes that share ontologies with FLII: view

Pathways for FLII Gene

SuperPathways for FLII Gene

No Data Available

Gene Ontology (GO) - Biological Process for FLII Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006936 muscle contraction TAS 9177775
GO:0007275 multicellular organismal development IEA --
GO:0030036 actin cytoskeleton organization IEA --
genes like me logo Genes that share ontologies with FLII: view

No data available for Pathways by source for FLII Gene

Compounds for FLII Gene

(1) Novoseek inferred chemical compound relationships for FLII Gene

Compound -log(P) Hits PubMed IDs
atp 7.74 6
genes like me logo Genes that share compounds with FLII: view

Transcripts for FLII Gene

Unigene Clusters for FLII Gene

Flightless I homolog (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FLII Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^
SP1:
SP2:
SP3: -
SP4:
SP5: - - - - - - - - - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

ExUns: 18a · 18b ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b · 25c ^ 26a · 26b ^ 27a · 27b · 27c ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32a ·
SP1: - -
SP2: - -
SP3:
SP4:
SP5: - - - -
SP6: -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15: - -
SP16:

Relevant External Links for FLII Gene

GeneLoc Exon Structure for
FLII
ECgene alternative splicing isoforms for
FLII

Expression for FLII Gene

mRNA expression in normal human tissues for FLII Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FLII Gene

This gene is overexpressed in Muscle - Skeletal (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FLII Gene

SOURCE GeneReport for Unigene cluster for FLII Gene Hs.513984

mRNA Expression by UniProt/SwissProt for FLII Gene

Q13045-FLII_HUMAN
Tissue specificity: Strongest expression in skeletal muscle with high expression also in the heart and lung.
genes like me logo Genes that share expressions with FLII: view

Orthologs for FLII Gene

This gene was present in the common ancestor of animals.

Orthologs for FLII Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FLII 36
  • 99.19 (n)
  • 99.29 (a)
FLII 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FLII 36
  • 90.46 (n)
  • 94.55 (a)
FLII 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FLII 36
  • 90.95 (n)
  • 96.56 (a)
FLII 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Flii 36
  • 88.47 (n)
  • 95.11 (a)
Flii 16
Flii 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FLII 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FLII 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Flii 36
  • 88.2 (n)
  • 94.87 (a)
chicken
(Gallus gallus)
Aves FLII 36
  • 82.9 (n)
  • 87.75 (a)
FLII 37
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FLII 37
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia flii 36
  • 76.81 (n)
  • 83.16 (a)
zebrafish
(Danio rerio)
Actinopterygii flii 36
  • 73.95 (n)
  • 83.48 (a)
flii 37
  • 84 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011292 36
  • 62.76 (n)
  • 57.75 (a)
fruit fly
(Drosophila melanogaster)
Insecta fliI 36
  • 62.06 (n)
  • 57.84 (a)
fliI 37
  • 57 (a)
OneToOne
fliI 38
  • 56 (a)
worm
(Caenorhabditis elegans)
Secernentea fli-1 36
  • 51.63 (n)
  • 51.96 (a)
fli-1 37
  • 51 (a)
OneToOne
sup-5 38
  • 49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10255 37
  • 61 (a)
OneToOne
Species with no ortholog for FLII:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FLII Gene

ENSEMBL:
Gene Tree for FLII (if available)
TreeFam:
Gene Tree for FLII (if available)

Paralogs for FLII Gene

Paralogs for FLII Gene

genes like me logo Genes that share paralogs with FLII: view

Variants for FLII Gene

Sequence variations from dbSNP and Humsavar for FLII Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2071241 -- 18,253,227(-) CCACC(C/T)TGTGG intron-variant
rs2071242 -- 18,251,196(-) CCCCA(A/G)CTCCA intron-variant
rs2473657 -- 18,249,987(+) GTGGT(A/G)GCACA intron-variant
rs2605130 -- 18,257,787(+) AACCT(C/G)GCTCC intron-variant
rs2605139 -- 18,247,333(+) GTCCC(A/C)ATTCT missense, reference

Structural Variations from Database of Genomic Variants (DGV) for FLII Gene

Variant ID Type Subtype PubMed ID
nsv155 OTHER Inversion 15895083
nsv499114 OTHER Inversion 21111241
dgv3078n71 CNV Loss 21882294
nsv9503 CNV Gain 18304495
nsv907776 CNV Loss 21882294
nsv907777 CNV Loss 21882294

Relevant External Links for FLII Gene

HapMap Linkage Disequilibrium report
FLII

Disorders for FLII Gene

(1) MalaCards Diseases for FLII Gene

Search for FLII Gene in MalaCards »

(2) University of Copenhagen DISEASES for FLII Gene

(2) Novoseek inferred disease relationships for FLII Gene

Disease -log(P) Hits PubMed IDs
ewings sarcoma 51.2 2
tumors 0 2

Relevant External Links for FLII

Genetic Association Database (GAD)
FLII
Human Genome Epidemiology (HuGE) Navigator
FLII
genes like me logo Genes that share disorders with FLII: view

No data available for UniProtKB/Swiss-Prot for FLII Gene

Publications for FLII Gene

  1. Genomic structure, evolution, and expression of human FLII, a gelsolin and leucine-rich-repeat family member: overlap with LLGL. (PMID: 9177775) Campbell H.D. … Lupski J.R. (Genomics 1997) 3 4 23
  2. Identification of the binding partners for flightless I, a novel protein bridging the leucine-rich repeat and the gelsolin superfamilies. (PMID: 9525888) Liu Y.-T. … Yin H.L. (J. Biol. Chem. 1998) 3 4 23
  3. The human homologue of the Drosophila melanogaster flightless-I gene (flil) maps within the Smith-Magenis microdeletion critical region in 17p11.2. (PMID: 7825574) Chen K.S. … Lupski J.R. (Am. J. Hum. Genet. 1995) 2 3 23
  4. Identification of Flightless-I as a substrate of the cytokine- independent survival kinase CISK. (PMID: 19293151) Xu J. … Songyang Z. (J. Biol. Chem. 2009) 3 4 23
  5. Flightless-I, a gelsolin family member and transcriptional regulator, preferentially binds directly to activated cytosolic CaMK-II. (PMID: 18588881) Seward M.E. … Tombes R.M. (FEBS Lett. 2008) 3 23

Products for FLII Gene

Sources for FLII Gene

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