Aliases for FLII Gene
External Ids for FLII Gene
Previous GeneCards Identifiers for FLII Gene
This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
GeneCards Summary for FLII Gene
FLII (FLII, Actin Remodeling Protein) is a Protein Coding gene. Diseases associated with FLII include Smith-Magenis Syndrome and Ewing Sarcoma. Among its related pathways are Cytoskeletal Signaling. GO annotations related to this gene include actin binding. An important paralog of this gene is SVIL.
UniProtKB/Swiss-Prot for FLII Gene
May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation.