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Aliases for FLI1 Gene

Aliases for FLI1 Gene

  • Fli-1 Proto-Oncogene, ETS Transcription Factor 2 3
  • Friend Leukemia Virus Integration 1 2 3
  • Transcription Factor ERGB 3 4
  • Ewing Sarcoma Breakpoint Region 2 3
  • Proto-Oncogene Fli-1 4
  • EWSR2 3
  • SIC-1 3

External Ids for FLI1 Gene

Previous GeneCards Identifiers for FLI1 Gene

  • GC11P130564
  • GC11P130076
  • GC11P128596
  • GC11P128101
  • GC11P128069
  • GC11P124510

Summaries for FLI1 Gene

Entrez Gene Summary for FLI1 Gene

  • This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for FLI1 Gene

FLI1 (Fli-1 Proto-Oncogene, ETS Transcription Factor) is a Protein Coding gene. Diseases associated with FLI1 include peripheral primitive neuroectodermal tumor and ewing sarcoma. Among its related pathways are Transcriptional misregulation in cancer and NF-kappaB Signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is ETV2.

UniProtKB/Swiss-Prot for FLI1 Gene

  • Sequence-specific transcriptional activator. Recognizes the DNA sequence 5-C[CA]GGAAGT-3

Gene Wiki entry for FLI1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLI1 Gene

Genomics for FLI1 Gene

Regulatory Elements for FLI1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FLI1 Gene

Chromosome:
11
Start:
128,686,535 bp from pter
End:
128,813,267 bp from pter
Size:
126,733 bases
Orientation:
Plus strand

Genomic View for FLI1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FLI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FLI1 Gene

Proteins for FLI1 Gene

  • Protein details for FLI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01543-FLI1_HUMAN
    Recommended name:
    Friend leukemia integration 1 transcription factor
    Protein Accession:
    Q01543
    Secondary Accessions:
    • B2R8H2
    • B4DFV4
    • B4DTC6
    • G3V183
    • Q14319
    • Q92480
    • Q9UE07

    Protein attributes for FLI1 Gene

    Size:
    452 amino acids
    Molecular mass:
    50982 Da
    Quaternary structure:
    • Can form homodimers or heterodimers with ETV6/TEL1
    Miscellaneous:
    • Located on a fragment of chromosome 11 flanked on the centromeric side by the acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation breakpoint and on the telomeric side by the Ewing- and neuroepithelioma-associated t(11;22) (q24;q12) breakpoint

    Three dimensional structures from OCA and Proteopedia for FLI1 Gene

    Alternative splice isoforms for FLI1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FLI1 Gene

Proteomics data for FLI1 Gene at MOPED

Post-translational modifications for FLI1 Gene

  • Ubiquitination at Lys 172
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FLI1 (Fli1)

No data available for DME Specific Peptides for FLI1 Gene

Domains & Families for FLI1 Gene

Gene Families for FLI1 Gene

Protein Domains for FLI1 Gene

Graphical View of Domain Structure for InterPro Entry

Q01543

UniProtKB/Swiss-Prot:

FLI1_HUMAN :
  • Contains 1 ETS DNA-binding domain.
  • Belongs to the ETS family.
Domain:
  • Contains 1 ETS DNA-binding domain.
  • Contains 1 PNT (pointed) domain.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with FLI1: view

Function for FLI1 Gene

Molecular function for FLI1 Gene

GENATLAS Biochemistry:
Friend and Cas-Br-E murine leukemia virus integration site
UniProtKB/Swiss-Prot Function:
Sequence-specific transcriptional activator. Recognizes the DNA sequence 5-C[CA]GGAAGT-3

Gene Ontology (GO) - Molecular Function for FLI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003677 DNA binding TAS 1522903
genes like me logo Genes that share ontologies with FLI1: view
genes like me logo Genes that share phenotypes with FLI1: view

Animal Models for FLI1 Gene

MGI Knock Outs for FLI1:

Animal Model Products

miRNA for FLI1 Gene

miRTarBase miRNAs that target FLI1
Targeted motifs for FLI1 Gene
HOMER Transcription Factor Regulatory Elements motif FLI1
  • Consensus sequence: NRYTTCCGGH Submotif: canonical Cell Type: CD8 GEO ID: GSE20898

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FLI1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targets for FLI1 Gene

Localization for FLI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLI1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FLI1 Gene COMPARTMENTS Subcellular localization image for FLI1 gene
Compartment Confidence
nucleus 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for FLI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with FLI1: view

Pathways & Interactions for FLI1 Gene

genes like me logo Genes that share pathways with FLI1: view

Pathways by source for FLI1 Gene

1 Cell Signaling Technology pathway for FLI1 Gene
1 KEGG pathway for FLI1 Gene

SIGNOR curated interactions for FLI1 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for FLI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0007599 hemostasis TAS 10891501
GO:0008015 blood circulation IEA --
genes like me logo Genes that share ontologies with FLI1: view

Drugs & Compounds for FLI1 Gene

(1) Drugs for FLI1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
serine Nutra 420

(1) Additional Compounds for FLI1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Oligonucleotide
genes like me logo Genes that share compounds with FLI1: view

Transcripts for FLI1 Gene

Unigene Clusters for FLI1 Gene

Friend leukemia virus integration 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FLI1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FLI1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - -
SP2: - - -
SP3: - - -
SP4:
SP5: -

Relevant External Links for FLI1 Gene

GeneLoc Exon Structure for
FLI1
ECgene alternative splicing isoforms for
FLI1

Expression for FLI1 Gene

mRNA expression in normal human tissues for FLI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FLI1 Gene

This gene is overexpressed in Whole Blood (x8.1) and Spleen (x5.5).

Protein differential expression in normal tissues from HIPED for FLI1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.1), CD8 Tcells (15.5), CD4 Tcells (11.0), and Blymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FLI1 Gene



SOURCE GeneReport for Unigene cluster for FLI1 Gene Hs.504281

genes like me logo Genes that share expression patterns with FLI1: view

Protein tissue co-expression partners for FLI1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FLI1 Gene

Orthologs for FLI1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FLI1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FLI1 35
  • 91.89 (n)
  • 95.8 (a)
FLI1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FLI1 35
  • 92.54 (n)
  • 97.56 (a)
FLI1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fli1 35
  • 90.93 (n)
  • 96.68 (a)
Fli1 16
Fli1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FLI1 35
  • 99.78 (n)
  • 100 (a)
FLI1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fli1 35
  • 90.86 (n)
  • 96.24 (a)
oppossum
(Monodelphis domestica)
Mammalia FLI1 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves FLI1 35
  • 82.67 (n)
  • 91.38 (a)
FLI1 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FLI1 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fli1 35
  • 73.6 (n)
  • 82.77 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1184 35
zebrafish
(Danio rerio)
Actinopterygii fli1 35
fli1a 35
  • 75.87 (n)
  • 81.29 (a)
fli1a 36
  • 81 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3935 35
fruit fly
(Drosophila melanogaster)
Insecta Ets21C 37
  • 46 (a)
Ets65A 37
  • 61 (a)
Ets21C 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C42D8.4 37
  • 79 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
Species with no ortholog for FLI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FLI1 Gene

ENSEMBL:
Gene Tree for FLI1 (if available)
TreeFam:
Gene Tree for FLI1 (if available)

Paralogs for FLI1 Gene

Paralogs for FLI1 Gene

(3) SIMAP similar genes for FLI1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FLI1: view

Variants for FLI1 Gene

Sequence variations from dbSNP and Humsavar for FLI1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs475952 -- 128,792,455(+) TTGCC(A/G)GGTGG intron-variant
rs476719 -- 128,776,491(+) ACTAA(A/T)CATAC intron-variant
rs490698 -- 128,767,518(-) TCCCA(A/G)TAAGC intron-variant
rs490732 -- 128,767,529(-) GTATT(C/T)GAATT intron-variant
rs494072 -- 128,779,857(+) CACAT(A/G)GCATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FLI1 Gene

Variant ID Type Subtype PubMed ID
nsv826128 CNV Gain 20364138
nsv543 CNV Insertion 18451855
nsv468891 CNV Loss 19166990
esv275021 CNV Gain+Loss 21479260
nsv526725 CNV Loss 19592680
nsv545 CNV Loss 18451855
nsv819457 CNV Gain 19587683
dgv250n67 CNV Loss 20364138
nsv820393 CNV Deletion 20802225
esv2745240 CNV Deletion 23290073
esv994512 CNV Deletion 20482838
esv2666423 CNV Deletion 23128226
nsv38628 CNV Loss 16902084
esv28700 CNV Gain 19812545

Variation tolerance for FLI1 Gene

Residual Variation Intolerance Score: 27.73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FLI1 Gene

HapMap Linkage Disequilibrium report
FLI1
Human Gene Mutation Database (HGMD)
FLI1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLI1 Gene

Disorders for FLI1 Gene

MalaCards: The human disease database

(32) MalaCards diseases for FLI1 Gene - From: GeneTests, Orphanet, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
peripheral primitive neuroectodermal tumor
  • ewing sarcoma
ewing sarcoma
  • neuroepithelioma
isolated delta-storage pool disease
  • isolated delta-spd
thrombocytopenia, paris-trousseau type
  • paris-trousseau thrombocytopenia
bladder sarcoma
  • sarcoma of bladder
- elite association
Search FLI1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FLI1_HUMAN
  • Ewing sarcoma (ES) [MIM:612219]: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving FLI1 is found in patients with Erwing sarcoma. Translocation t(11;22)(q24;q12) with EWSR1.

Relevant External Links for FLI1

Genetic Association Database (GAD)
FLI1
Human Genome Epidemiology (HuGE) Navigator
FLI1
Tumor Gene Database (TGDB):
FLI1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FLI1
genes like me logo Genes that share disorders with FLI1: view

No data available for Genatlas for FLI1 Gene

Publications for FLI1 Gene

  1. ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells. (PMID: 19168790) Stankiewicz M.J. … Crispino J.D. (Blood 2009) 23 67
  2. Continuous Fli-1 expression plays an essential role in the proliferation and survival of F-MuLV-induced erythroleukemia and human erythroleukemia. (PMID: 19282832) Cui J.W. … Ben-David Y. (Leukemia 2009) 23 67
  3. Immunohistochemical evaluation of FLI-1 in acute lymphoblastic lymphoma (ALL): a potential diagnostic pitfall. (PMID: 19349856) Lin O. … Teruya-Feldstein J. (Appl. Immunohistochem. Mol. Morphol. 2009) 23 67
  4. Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage. (PMID: 19666492) Kruse E.A. … Kile B.T. (Proc. Natl. Acad. Sci. U.S.A. 2009) 23 67
  5. Adhesion to fibronectin induces megakaryocytic differentiation of JAS-REN cells. (PMID: 18383854) Yamada H. … Horiguchi-Yamada J. (Anticancer Res. 2008) 23 67

Products for FLI1 Gene

Sources for FLI1 Gene

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