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Aliases for FLI1 Gene

Aliases for FLI1 Gene

  • Fli-1 Proto-Oncogene, ETS Transcription Factor 2 3 5
  • Friend Leukemia Virus Integration 1 2 3
  • Transcription Factor ERGB 3 4
  • Ewing Sarcoma Breakpoint Region 2 3
  • Proto-Oncogene Fli-1 4
  • EWSR2 3
  • SIC-1 3

External Ids for FLI1 Gene

Previous GeneCards Identifiers for FLI1 Gene

  • GC11P130564
  • GC11P130076
  • GC11P128596
  • GC11P128101
  • GC11P128069
  • GC11P124510

Summaries for FLI1 Gene

Entrez Gene Summary for FLI1 Gene

  • This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for FLI1 Gene

FLI1 (Fli-1 Proto-Oncogene, ETS Transcription Factor) is a Protein Coding gene. Diseases associated with FLI1 include Ewing Sarcoma and Isolated Delta-Storage Pool Disease. Among its related pathways are NF-kappaB Signaling and Transcriptional misregulation in cancer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is ETS2.

UniProtKB/Swiss-Prot for FLI1 Gene

  • Sequence-specific transcriptional activator. Recognizes the DNA sequence 5-C[CA]GGAAGT-3.

Gene Wiki entry for FLI1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLI1 Gene

Genomics for FLI1 Gene

Regulatory Elements for FLI1 Gene

Enhancers for FLI1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FLI1 on UCSC Golden Path with GeneCards custom track

Promoters for FLI1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FLI1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FLI1 Gene

128,686,535 bp from pter
128,813,267 bp from pter
126,733 bases
Plus strand

Genomic View for FLI1 Gene

Genes around FLI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FLI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FLI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FLI1 Gene

Proteins for FLI1 Gene

  • Protein details for FLI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Friend leukemia integration 1 transcription factor
    Protein Accession:
    Secondary Accessions:
    • B2R8H2
    • B4DFV4
    • B4DTC6
    • G3V183
    • Q14319
    • Q92480
    • Q9UE07

    Protein attributes for FLI1 Gene

    452 amino acids
    Molecular mass:
    50982 Da
    Quaternary structure:
    • Can form homodimers or heterodimers with ETV6/TEL1.
    • Located on a fragment of chromosome 11 flanked on the centromeric side by the acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation breakpoint and on the telomeric side by the Ewing- and neuroepithelioma-associated t(11;22) (q24;q12) breakpoint.

    Three dimensional structures from OCA and Proteopedia for FLI1 Gene

    Alternative splice isoforms for FLI1 Gene


neXtProt entry for FLI1 Gene

Proteomics data for FLI1 Gene at MOPED

Post-translational modifications for FLI1 Gene

  • Ubiquitination at Lys 172
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FLI1 (FLI1)
  • Abcam antibodies for FLI1

No data available for DME Specific Peptides for FLI1 Gene

Domains & Families for FLI1 Gene

Gene Families for FLI1 Gene

Protein Domains for FLI1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 ETS DNA-binding domain.
  • Belongs to the ETS family.
  • Contains 1 ETS DNA-binding domain.
  • Contains 1 PNT (pointed) domain.
  • Belongs to the ETS family.
genes like me logo Genes that share domains with FLI1: view

Function for FLI1 Gene

Molecular function for FLI1 Gene

GENATLAS Biochemistry:
Friend and Cas-Br-E murine leukemia virus integration site
UniProtKB/Swiss-Prot Function:
Sequence-specific transcriptional activator. Recognizes the DNA sequence 5-C[CA]GGAAGT-3.

Gene Ontology (GO) - Molecular Function for FLI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003682 chromatin binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FLI1: view
genes like me logo Genes that share phenotypes with FLI1: view

Human Phenotype Ontology for FLI1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FLI1 Gene

MGI Knock Outs for FLI1:

Animal Model Products

miRNA for FLI1 Gene

miRTarBase miRNAs that target FLI1
Targeted motifs for FLI1 Gene
HOMER Transcription Factor Regulatory Elements motif FLI1
  • Consensus sequence: NRYTTCCGGH Submotif: canonical Cell Type: CD8 GEO ID: GSE20898

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targets for FLI1 Gene

Localization for FLI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLI1 Gene

Subcellular locations from

Jensen Localization Image for FLI1 Gene COMPARTMENTS Subcellular localization image for FLI1 gene
Compartment Confidence
nucleus 5
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for FLI1 Gene

Pathways & Interactions for FLI1 Gene

genes like me logo Genes that share pathways with FLI1: view

Pathways by source for FLI1 Gene

1 Cell Signaling Technology pathway for FLI1 Gene
1 KEGG pathway for FLI1 Gene

SIGNOR curated interactions for FLI1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for FLI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008015 blood circulation IEA --
GO:0030154 cell differentiation IBA --
GO:0035855 megakaryocyte development IEA --
genes like me logo Genes that share ontologies with FLI1: view

Drugs & Compounds for FLI1 Gene

(1) Drugs for FLI1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for FLI1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FLI1: view

Transcripts for FLI1 Gene

Unigene Clusters for FLI1 Gene

Friend leukemia virus integration 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FLI1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - -
SP2: - - -
SP3: - - -
SP5: -

Relevant External Links for FLI1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FLI1 Gene

mRNA expression in normal human tissues for FLI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FLI1 Gene

This gene is overexpressed in Whole Blood (x8.1) and Spleen (x5.5).

Protein differential expression in normal tissues from HIPED for FLI1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.1), CD8 Tcells (15.5), CD4 Tcells (11.0), and Blymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FLI1 Gene

SOURCE GeneReport for Unigene cluster for FLI1 Gene Hs.504281

genes like me logo Genes that share expression patterns with FLI1: view

Protein tissue co-expression partners for FLI1 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for FLI1 Gene

Orthologs for FLI1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FLI1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FLI1 35
  • 91.89 (n)
  • 95.8 (a)
FLI1 36
  • 95 (a)
(Canis familiaris)
Mammalia FLI1 35
  • 92.54 (n)
  • 97.56 (a)
FLI1 36
  • 98 (a)
(Mus musculus)
Mammalia Fli1 35
  • 90.93 (n)
  • 96.68 (a)
Fli1 16
Fli1 36
  • 97 (a)
(Pan troglodytes)
Mammalia FLI1 35
  • 99.78 (n)
  • 100 (a)
FLI1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fli1 35
  • 90.86 (n)
  • 96.24 (a)
(Monodelphis domestica)
Mammalia FLI1 36
  • 92 (a)
(Gallus gallus)
Aves FLI1 35
  • 82.67 (n)
  • 91.38 (a)
FLI1 36
  • 91 (a)
(Anolis carolinensis)
Reptilia FLI1 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fli1 35
  • 73.6 (n)
  • 82.77 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1184 35
(Danio rerio)
Actinopterygii fli1 35
fli1a 35
  • 75.87 (n)
  • 81.29 (a)
fli1a 36
  • 81 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3935 35
fruit fly
(Drosophila melanogaster)
Insecta Ets21C 37
  • 46 (a)
Ets65A 37
  • 61 (a)
Ets21C 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea C42D8.4 37
  • 79 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
-- 36
  • 30 (a)
-- 36
  • 30 (a)
Species with no ortholog for FLI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FLI1 Gene

Gene Tree for FLI1 (if available)
Gene Tree for FLI1 (if available)

Paralogs for FLI1 Gene

Paralogs for FLI1 Gene

(3) SIMAP similar genes for FLI1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FLI1: view

Variants for FLI1 Gene

Sequence variations from dbSNP and Humsavar for FLI1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs519036 -- 128,788,268(+) agttc(A/G)agacc intron-variant
rs519529 -- 128,780,307(+) AGGCA(A/G)TTGGA intron-variant
rs519913 -- 128,770,953(-) TACCT(C/T)ACCTG intron-variant
rs524839 -- 128,790,313(+) AGAGA(A/G)AGAAC intron-variant
rs525019 -- 128,780,898(+) CCCTC(A/G)TTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FLI1 Gene

Variant ID Type Subtype PubMed ID
nsv826128 CNV Gain 20364138
nsv543 CNV Insertion 18451855
nsv468891 CNV Loss 19166990
esv275021 CNV Gain+Loss 21479260
nsv526725 CNV Loss 19592680
nsv545 CNV Loss 18451855
nsv819457 CNV Gain 19587683
dgv250n67 CNV Loss 20364138
nsv820393 CNV Deletion 20802225
esv2745240 CNV Deletion 23290073
esv994512 CNV Deletion 20482838
esv2666423 CNV Deletion 23128226
nsv38628 CNV Loss 16902084
esv28700 CNV Gain 19812545

Variation tolerance for FLI1 Gene

Residual Variation Intolerance Score: 27.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FLI1 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLI1 Gene

Disorders for FLI1 Gene

MalaCards: The human disease database

(27) MalaCards diseases for FLI1 Gene - From: GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ewing sarcoma
  • neuroepithelioma
isolated delta-storage pool disease
  • isolated delta-spd
extraskeletal ewing sarcoma
  • extraosseous ewing sarcoma
thrombocytopenia, paris-trousseau type
  • paris-trousseau thrombocytopenia
- elite association - COSMIC cancer census association via MalaCards
Search FLI1 in MalaCards View complete list of genes associated with diseases


  • Ewing sarcoma (ES) [MIM:612219]: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. {ECO:0000269 PubMed:1522903, ECO:0000269 PubMed:1765382}. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving FLI1 is found in patients with Erwing sarcoma. Translocation t(11;22)(q24;q12) with EWSR1. {ECO:0000269 PubMed:1522903, ECO:0000269 PubMed:1765382}.

Relevant External Links for FLI1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Tumor Gene Database (TGDB):
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FLI1: view

No data available for Genatlas for FLI1 Gene

Publications for FLI1 Gene

  1. The human homolog of the mouse common viral integration region, FLI1, maps to 11q23-q24. (PMID: 1765382) Baud V. … Bergeron D. (Genomics 1991) 2 3 4 67
  2. Immunohistochemical evaluation of FLI-1 in acute lymphoblastic lymphoma (ALL): a potential diagnostic pitfall. (PMID: 19349856) Lin O. … Teruya-Feldstein J. (Appl. Immunohistochem. Mol. Morphol. 2009) 3 23
  3. Fli-1 expression in malignant melanoma. (PMID: 18785112) Torlakovic E.E. … Bilalovic N. (Histol. Histopathol. 2008) 3 23
  4. Ewing's sarcoma fusion protein, EWS/Fli-1 and Fli-1 protein induce PLD2 but not PLD1 gene expression by binding to an ETS domain of 5' promoter. (PMID: 16964281) Kikuchi R. … Murate T. (Oncogene 2007) 3 23
  5. Functional roles of Fli-1, a member of the Ets family of transcription factors, in human breast malignancy. (PMID: 17727680) Sakurai T. … Oikawa T. (Cancer Sci. 2007) 3 23

Products for FLI1 Gene

Sources for FLI1 Gene