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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FLI1 Gene

protein-coding   GIFtS: 68
GCID: GC11P128596

Fli-1 Proto-Oncogene, ETS Transcription Factor

(Previous name: Friend leukemia virus integration 1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fli-1 Proto-Oncogene, ETS Transcription Factor1 2     EWSR22
Friend Leukemia Virus Integration 11 2     SIC-12
Proto-Oncogene Fli-12 3     Ewing Sarcoma Breakpoint Region 22
Transcription Factor ERGB2 3     Friend Leukemia Integration 1 Transcription Factor2

External Ids:    HGNC: 37491   Entrez Gene: 23132   Ensembl: ENSG000001517027   OMIM: 1930675   UniProtKB: Q015433   

Export aliases for FLI1 gene to outside databases

Previous GC identifers: GC11P130564 GC11P130076 GC11P128101 GC11P128069 GC11P124510


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FLI1 Gene:
This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a
t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that
is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23)
translocation involving this gene has also been identified. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Aug 2012)

GeneCards Summary for FLI1 Gene: 
FLI1 (Fli-1 proto-oncogene, ETS transcription factor) is a protein-coding gene. Diseases associated with FLI1 include paris-trousseau thrombocytopenia, and small cell sarcoma. GO annotations related to this gene include RNA polymerase II distal enhancer sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ELK4.

UniProtKB/Swiss-Prot: FLI1_HUMAN, Q01543
Function: Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'

Gene Wiki entry for FLI1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FLI1 gene promoter:
         AML1a   AP-1   MyoD   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFLI1 promoter sequence
   Search SABiosciences Chromatin IP Primers for FLI1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FLI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.1-q24.3   Ensembl cytogenetic band:  11q24.3   HGNC cytogenetic band: 11q24.1-q24.3

FLI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FLI1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P128596:  view genomic region     (about GC identifiers)

Start:
128,555,046 bp from pter      End:
128,683,162 bp from pter
Size:
128,117 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FLI1_HUMAN, Q01543 (See protein sequence)
Recommended Name: Friend leukemia integration 1 transcription factor  
Size: 452 amino acids; 50982 Da
Subunit: Can form homodimers or heterodimers with ETV6/TEL1
Subcellular location: Nucleus
Miscellaneous: Located on a fragment of chromosome 11 flanked on the centromeric side by the acute lymphoblastic
leukemia-associated t(4;11)(q21;q23) translocation breakpoint and on the telomeric side by the Ewing- and
neuroepithelioma-associated t(11;22) (q24;q12) breakpoint
3 PDB 3D structures from and Proteopedia for FLI1:
1FLI (3D)        1X66 (3D)        2YTU (3D)    
Secondary accessions: B2R8H2 B4DFV4 B4DTC6 G3V183 Q14319 Q92480 Q9UE07
Alternative splicing: 4 isoforms:  Q01543-1   Q01543-2   Q01543-3   Q01543-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FLI1: NX_Q01543

Explore proteomics data for FLI1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q01543

  • FLI1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FLI1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001161153.1  NP_001257939.1  NP_001257941.1  NP_002008.2  

    ENSEMBL proteins: 
     ENSP00000437124   ENSP00000399985   ENSP00000433488   ENSP00000432950   ENSP00000339627  
     ENSP00000281428  

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    Cloud-Clone Corp. Proteins for FLI1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    FLI1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR000418 Ets_dom
     IPR011991 WHTH_DNA-bd_dom
     IPR003118 Pointed_dom
     IPR013761 SAM/pointed

    Graphical View of Domain Structure for InterPro Entry Q01543

    ProtoNet protein and cluster: Q01543

    1 Blocks protein domain: IPB003118 Sterile alpha motif (SAM)/Pointed domain

    UniProtKB/Swiss-Prot: FLI1_HUMAN, Q01543
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain
    Similarity: Contains 1 PNT (pointed) domain


    FLI1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FLI1_HUMAN, Q01543
    Function: Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'

         Genatlas biochemistry entry for FLI1:
    Friend and Cas-Br-E murine leukemia virus integration site

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding IEA--
    GO:0003677DNA binding TAS1522903
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding ----
         
    FLI1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FLI1:
     Decreased G3BP1 protein expres 

         11 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Fli1):
     cardiovascular system  cellular  embryogenesis  growth/size  hematopoietic system 
     immune system  liver/biliary system  mortality/aging  muscle  nervous system 
     tumorigenesis 

    FLI1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FLI1: Fli1tm1Adh Fli1tm1Ber Fli1tm1.1Morl Fli1tm1Dkw Fli1tm2Adh Fli1tm1.1Dkw

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FLI1 
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    miRNA
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    hsa-mir-145 (MIRT004496), hsa-mir-155 (MIRT005349)

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    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate FLI1 (see all 47):
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    SwitchGear 3'UTR luciferase reporter plasmidFLI1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FLI1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    2Lymphocyte Signaling
    Lymphocyte Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for FLI1
        Lymphocyte Signaling



    1         Kegg Pathway  (Kegg details for FLI1):
        Transcriptional misregulation in cancer


    FLI1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FLI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/13 Interacting proteins for FLI1 (Q015432, 3 ENSP000003396274) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD9O151982, 3MINT-61936 MINT-62072 I2D: score=4 
    ETV6P412123, ENSP000002664274I2D: score=3 STRING: ENSP00000266427
    GATA1P159763, ENSP000003658584I2D: score=3 STRING: ENSP00000365858
    TDP2O955513, ENSP000003674404I2D: score=3 STRING: ENSP00000367440
    SRFP118313, ENSP000002653544I2D: score=2 STRING: ENSP00000265354
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007599hemostasis TAS10891501
    GO:0008015blood circulation IEA--
    GO:0009887organ morphogenesis IEA--

    FLI1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FLI1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FLI1

    2 Novoseek inferred chemical compound relationships for FLI1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oligonucleotide 0 1 8238248 (1)
    serine 0 1 15809330 (1)

    Search CenterWatch for drugs/clinical trials and news about FLI1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FLI1 gene (4 alternative transcripts): 
    NM_001167681.2  NM_001271010.1  NM_001271012.1  NM_002017.4  

    Unigene Cluster for FLI1:

    Friend leukemia virus integration 1
    Hs.504281  [show with all ESTs]
    Unigene Representative Sequence: NM_001271010
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527767(uc001qen.3) ENST00000525560 ENST00000429175 ENST00000527786
    ENST00000534087 ENST00000528790 ENST00000344954(uc010sbt.2 uc010sbv.2 uc010sbu.2 uc009zci.3)
    ENST00000281428
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate FLI1 (see all 47):
    hsa-miR-520f hsa-miR-193a-3p hsa-miR-429 hsa-miR-4328 hsa-miR-605 hsa-let-7a-2* hsa-miR-371-5p hsa-miR-3916
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK294279.1 AK300153.1 AK313370.1 AY029368.1 BC001670.1 BC010115.1 M93255.1 M98833.3 
    S45205.1 S64709.1 S72620.1 X67001.1 

    6 DOTS entries:

    DT.315565  DT.91981587  DT.207655  DT.91669639  DT.100665472  DT.99933688 

    24/132 AceView cDNA sequences (see all 132):

    CR600005 AA664465 AI216469 BF224181 AA805688 BF899604 AW340324 AA256529 
    AU118654 BQ953977 AI468916 BQ232274 BC001670 BQ215477 AI354789 BX281437 
    BX328036 BC010115 AA862270 BG257780 AI457281 BQ642921 AA863340 BE831331 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for FLI1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
    SP1:                                      -                 -                                       
    SP2:                          -           -                 -                                       
    SP3:        -                 -           -                                                         
    SP4:                                                                                                
    SP5:                          -                                                                     


    ECgene alternative splicing isoforms for FLI1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FLI1 expression in normal human tissues (normalized intensities)      FLI1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTAAAATA
    FLI1 Expression
    About this image


    FLI1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Primitive Heart Tube Cells Primitive Heart Tube
             Heart Tube
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Human umbilical vein endothelial cells (HUVEC)
             Human Umbilical Vein Endothelial Cells (HUVEC) (ScienceCell)   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             pbmc   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Human Umbilical Vein Endothelial Cells (HUVEC) (ScienceCell)   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles

    See FLI1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FLI1

    SOURCE GeneReport for Unigene cluster: Hs.504281
        SABiosciences Custom PCR Arrays for FLI1
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FLI1 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fli11 , 5 Friend leukemia integration 11, 5 90.93(n)1
    96.68(a)1
      9 (17.74 cM)5
    142471  NM_008026.41  NP_032052.11 
     324222085 
    chicken
    (Gallus gallus)
    Aves FLI11 Friend leukemia virus integration 1 82.67(n)
    91.38(a)
      419723  NM_001030908.1  NP_001026079.1 
    lizard
    (Anolis carolinensis)
    Reptilia FLI16
    --
    --
    87(a)
    57(a)
    1 ↔ 1
    possible ortholog
    GL343197.1(4343646-4401011)
    GL343514.1(326230-363273)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.11842 X.laevis mRNA XLFLI 78.29(n)    X66979.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fli12 friend leukemia integration 1 80.09(n)   30619  BC056588.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ets65A3 DNA binding 61(a)
    (best of 2)
      65A6   --
    worm
    (Caenorhabditis elegans)
    Secernentea C42D8.43 DNA-binding protein 79(a)   X(5114542-5116802)   --


    ENSEMBL Gene Tree for FLI1 (if available)
    TreeFam Gene Tree for FLI1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FLI1 gene
    ELK42  ETV12  ETV32  ERF2  ETV52  ETV3L2  ETS12  GABPA2  
    ETS22  ELK12  ERG2  FEV2  ETV42  ETV22  ELK32  
    4 SIMAP similar genes for FLI1 using alignment to 4 protein entries:     FLI1_HUMAN (see all proteins):
    ERG    NDRG1-ERG fusion    EWSR1/FLI1 fusion    FEV

    FLI1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2892 SNPs in FLI1 are shown (see all 2892)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs112972511,2
    C--124512690(+) GGCGAC/-CCTCC 4 -- int11Minor allele frequency- -:0.00NA 2
    rs112972521,2
    C--124512708(+) CCCAG-/CCCCCA 4 -- int10--------
    rs112972531,2
    C--124512721(+) TGGAGC/-CCCGG 4 -- int12Minor allele frequency- -:0.00NA 4
    rs112972541,2
    C--124512726(+) CCCGGC/-CCCCC 4 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs781443481,2
    C--124512750(+) CCGCC-/GGGGCT 4 -- int10--------
    rs723233731,2
    C--124572310(+) GGGGA-/TGTG  
            
    TGTGT
    4 -- int10--------
    rs354031291,2
    C--124595398(+) CCTGG-/AAAAAA 4 -- int11Minor allele frequency- A:0.00CSA 2
    rs356234901,2
    C--124598653(+) AAAAA-/ATAAAT 4 -- int11Minor allele frequency- A:0.50CSA 2
    rs32168141,2
    C--124600215(+) CCAAAG/-ATTTT 4 -- int13Minor allele frequency- -:0.17NA CSA 6
    rs344127021,2
    C--124602890(+) AGAGC-/TGTGTGT 4 -- int10--------

    HapMap Linkage Disequilibrium report for FLI1 (128555046 - 128683162 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for FLI1 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv994512CNV Deletion20482838
    nsv820393CNV Deletion20802225
    esv2666423CNV Deletion23128226
    esv2745240CNV Deletion23290073
    nsv543CNV Insertion18451855
    nsv545CNV Loss18451855
    nsv38628CNV Loss16902084
    nsv468891CNV Loss19166990
    nsv526725CNV Loss19592680
    dgv250n67CNV Loss20364138

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 193067    OMIM disorders: --

    UniProtKB/Swiss-Prot: FLI1_HUMAN, Q01543
  • Ewing sarcoma (ES) [MIM:612219]: A highly malignant, metastatic, primitive small round cell tumor of bone
    and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group
    of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural
    tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the
    tumors. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration
    involving FLI1 is found in patients with Erwing sarcoma. Translocation t(11;22)(q24;q12) with EWSR1

  • 20/51 diseases for FLI1 (see all 51):    About MalaCards
    paris-trousseau thrombocytopenia    small cell sarcoma    kaposiform hemangioendothelioma    central nervous system cancer
    jacobsen syndrome    nervous system cancer    horner's syndrome    embryonal cancer
    melanoma of soft part    peripheral primitive neuroectodermal tumor    hemangioendothelioma    sarcoma
    ewing's family of tumors    angiosarcoma    neuroepithelioma    acute lymphoblastic leukemia
    lymphoblastic leukemia    desmoplastic small round cell tumor    primitive neuroectodermal tumor    cutaneous leishmaniasis

    6 diseases from the University of Copenhagen DISEASES database for FLI1:
    Peripheral primitive neuroectodermal tumor     Sarcoma     Primitive neuroectodermal tumor     Synovial sarcoma
    Rhabdomyosarcoma     Connective tissue benign neoplasm

    FLI1 for disorders           About GeneDecksing

    10/33 Novoseek inferred disease relationships for FLI1 gene (see all 33)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ewings sarcoma 93.4 78 12522555 (4), 16837212 (3), 8039423 (3), 16865286 (2) (see all 58)
    friend leukemia 83.5 5 15557108 (1), 18785112 (1), 19349856 (1), 1406633 (1) (see all 5)
    peripheral neuroepithelioma 75.2 1 8039423 (1)
    erythroleukemia 71.5 27 2044959 (4), 19282832 (4), 8502483 (4), 8336942 (2) (see all 14)
    neuroectodermal tumors 69.7 1 16046110 (1)
    vascular neoplasms 63.9 6 15001993 (3), 11474291 (2)
    sarcoma synovial 56.4 1 11117787 (1)
    leukemia 51.3 20 9178886 (2), 2044959 (2), 10772879 (2), 8336942 (2) (see all 15)
    rhabdomyosarcoma 50.5 2 11117787 (1), 16917000 (1)
    sarcoma 49.4 2 11474291 (1), 8336942 (1)

    Genetic Association Database (GAD): FLI1
    Human Genome Epidemiology (HuGE) Navigator: FLI1 (7 documents)
    Tumor Gene Database (TGDB): FLI1

    Export disorders for FLI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FLI1 gene, integrated from 9 sources (see all 247):
    (articles sorted by number of sources associating them with FLI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human homolog of the mouse common viral integration region, FLI1, maps to 11q23-q24. (PubMed id 1765382)1, 2, 3 Baud V.... Bergeron D. (1991)
    2. Solution structure of the ets domain of Fli-1 when bound to DNA. (PubMed id 7773776)1, 2, 9 Liang H.... Fesik S.W. (1994)
    3. Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. (PubMed id 18174230)1, 4, 9 Miyagawa H....Horiuchi T. (2008)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Chromosome translocation based on illegitimate recombination in human tumors. (PubMed id 9751743)1, 2 Zucman-Rossi J.... Thomas G. (1998)
    7. Molecular analysis of a t(11;22) translocation junction in a case of Ewing's sarcoma. (PubMed id 7542907)1, 2 Bhagirath T.... Yoshida M.C. (1995)
    8. Human FLI-1 localizes to chromosome 11q24 and has an aberrant transcript in neuroepithelioma. (PubMed id 8439553)1, 2 Hromas R....Klemsz M.J. (1993)
    9. Structure and expression of human Fli-1 gene. (PubMed id 1394211)1, 2 Prasad D.D.... Reddy E.S. (1992)
    10. The ERGB/Fli-1 gene: isolation and characterization of a new member of the family of human ETS transcription factors. (PubMed id 1445800)1, 2 Watson D.K.... Seth A. (1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2313 HGNC: 3749 AceView: FLI1 Ensembl:ENSG00000151702 euGenes: HUgn2313
    ECgene: FLI1 Kegg: 2313 H-InvDB: FLI1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FLI1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FLI1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FLI1 gene:
    Search GeneIP for patents involving FLI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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