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FLI1 Gene

protein-coding   GIFtS: 69
GCID: GC11P128596

Fli-1 Proto-Oncogene, ETS Transcription Factor

(Previous name: Friend leukemia virus integration 1)
  See FLI1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fli-1 Proto-Oncogene, ETS Transcription Factor1 2     EWSR22
Friend Leukemia Virus Integration 11 2     SIC-12
Proto-Oncogene Fli-12 3     Ewing Sarcoma Breakpoint Region 22
Transcription Factor ERGB2 3     Friend Leukemia Integration 1 Transcription Factor2

External Ids:    HGNC: 37491   Entrez Gene: 23132   Ensembl: ENSG000001517027   OMIM: 1930675   UniProtKB: Q015433   

Export aliases for FLI1 gene to outside databases

Previous GC identifers: GC11P130564 GC11P130076 GC11P128101 GC11P128069 GC11P124510


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FLI1 Gene:
This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a
t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that
is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23)
translocation involving this gene has also been identified. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Aug 2012)

GeneCards Summary for FLI1 Gene:
FLI1 (Fli-1 proto-oncogene, ETS transcription factor) is a protein-coding gene. Diseases associated with FLI1 include isolated delta-storage pool disease, and paris-trousseau thrombocytopenia. GO annotations related to this gene include RNA polymerase II distal enhancer sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ETV1.

UniProtKB/Swiss-Prot: FLI1_HUMAN, Q01543
Function: Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'

Gene Wiki entry for FLI1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the FLI1 gene promoter:
         AML1a   AP-1   MyoD   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFLI1 promoter sequence
   Search Chromatin IP Primers for FLI1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FLI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.1-q24.3   Ensembl cytogenetic band:  11q24.3   HGNC cytogenetic band: 11q24.1-q24.3

FLI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FLI1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P128596:  view genomic region     (about GC identifiers)

Start:
128,556,430 bp from pter      End:
128,683,162 bp from pter
Size:
126,733 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FLI1_HUMAN, Q01543 (See protein sequence)
Recommended Name: Friend leukemia integration 1 transcription factor  
Size: 452 amino acids; 50982 Da
Subunit: Can form homodimers or heterodimers with ETV6/TEL1
Miscellaneous: Located on a fragment of chromosome 11 flanked on the centromeric side by the acute lymphoblastic
leukemia-associated t(4;11)(q21;q23) translocation breakpoint and on the telomeric side by the Ewing- and
neuroepithelioma-associated t(11;22) (q24;q12) breakpoint
3 PDB 3D structures from and Proteopedia for FLI1:
1FLI (3D)        1X66 (3D)        2YTU (3D)    
Secondary accessions: B2R8H2 B4DFV4 B4DTC6 G3V183 Q14319 Q92480 Q9UE07
Alternative splicing: 4 isoforms:  Q01543-1   Q01543-2   Q01543-3   Q01543-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FLI1: NX_Q01543

Explore proteomics data for FLI1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys172
  • Modification sites at PhosphoSitePlus

  • See FLI1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001161153.1  NP_001257939.1  NP_001257941.1  NP_002008.2  

    ENSEMBL proteins: 
     ENSP00000477262   ENSP00000476428   ENSP00000433488   ENSP00000399985   ENSP00000432950  
     ENSP00000339627   ENSP00000437124   ENSP00000281428  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR000418 Ets_dom
     IPR011991 WHTH_DNA-bd_dom
     IPR003118 Pointed_dom
     IPR013761 SAM/pointed

    Graphical View of Domain Structure for InterPro Entry Q01543

    ProtoNet protein and cluster: Q01543

    1 Blocks protein domain: IPB003118 Sterile alpha motif (SAM)/Pointed domain

    UniProtKB/Swiss-Prot: FLI1_HUMAN, Q01543
    Similarity: Belongs to the ETS family
    Similarity: Contains 1 ETS DNA-binding domain
    Similarity: Contains 1 PNT (pointed) domain


    Find genes that share domains with FLI1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FLI1_HUMAN, Q01543
    Function: Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'

         Genatlas biochemistry entry for FLI1:
    Friend and Cas-Br-E murine leukemia virus integration site

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding ----
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
    GO:0003677DNA binding TAS1522903
    GO:0003682chromatin binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity TAS10891501
         
    Find genes that share ontologies with FLI1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FLI1:
     Decreased G3BP1 protein expres 

         11 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Fli1):
     cardiovascular system  cellular  embryogenesis  growth/size/body  hematopoietic system 
     immune system  liver/biliary system  mortality/aging  muscle  nervous system 
     tumorigenesis 

    Find genes that share phenotypes with FLI1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FLI1: Fli1tm1Adh Fli1tm1Ber Fli1tm1.1Morl Fli1tm1Dkw Fli1tm2Adh Fli1tm1.1Dkw

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FLI1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FLI1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FLI1

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  NRYTTCCGGH 

    miRNA
    Products:
        
    miRTarBase miRNAs that target FLI1:
    hsa-mir-145-5p (MIRT004496), hsa-mir-124-3p (MIRT023015), hsa-mir-155-5p (MIRT005349)

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    Selected qRT-PCR Assays for microRNAs that regulate FLI1 (see all 47):
    hsa-miR-520f hsa-miR-193a-3p hsa-miR-429 hsa-miR-4328 hsa-miR-605 hsa-let-7a-2* hsa-miR-371-5p hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmidFLI1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FLI1

    Gene Editing
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    Sino Biological Human cDNA Clone for FLI1
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    eBioscience FlowRNA Probe Sets ( VA1-11552) for FLI1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FLI1_HUMAN, Q01543: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--

    Find genes that share ontologies with FLI1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FLI1 About    
    See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    2Lymphocyte Signaling
    Lymphocyte Signaling


    Find genes that share SuperPaths with FLI1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for FLI1
        Lymphocyte Signaling



    1 Kegg Pathway  (Kegg details for FLI1):
        Transcriptional misregulation in cancer

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FLI1
    Interactions:

        GeneGlobe Interaction Network for FLI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for FLI1 (Q015432, 3 ENSP000003396274) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD9O151982, 3MINT-61936 MINT-62072 I2D: score=4 
    ETV6P412123, ENSP000002664274I2D: score=3 STRING: ENSP00000266427
    GATA1P159763, ENSP000003658584I2D: score=3 STRING: ENSP00000365858
    TDP2O955513, ENSP000003674404I2D: score=3 STRING: ENSP00000367440
    SRFP118313, ENSP000002653544I2D: score=2 STRING: ENSP00000265354
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IBA--
    GO:0006366transcription from RNA polymerase II promoter IBA--
    GO:0007599hemostasis TAS10891501

    Find genes that share ontologies with FLI1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FLI1

    2 Novoseek inferred chemical compound relationships for FLI1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oligonucleotide 0 1 8238248 (1)
    serine 0 1 15809330 (1)



    Find genes that share compounds with FLI1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FLI1 gene (4 alternative transcripts): 
    NM_001167681.2  NM_001271010.1  NM_001271012.1  NM_002017.4  

    Unigene Cluster for FLI1:

    Friend leukemia virus integration 1
    Hs.504281  [show with all ESTs]
    Unigene Representative Sequence: NM_001271010
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000608303 ENST00000527767(uc001qen.3) ENST00000527786 ENST00000429175
    ENST00000534087 ENST00000608055 ENST00000528790 ENST00000344954(uc010sbt.2 uc010sbv.2 uc010sbu.2 uc009zci.3)
    ENST00000525560 ENST00000281428
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    hsa-miR-520f hsa-miR-193a-3p hsa-miR-429 hsa-miR-4328 hsa-miR-605 hsa-let-7a-2* hsa-miR-371-5p hsa-miR-3916
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK294279.1 AK300153.1 AK313370.1 AY029368.1 BC001670.1 BC010115.1 M93255.1 M98833.3 
    S45205.1 S64709.1 S72620.1 X67001.1 

    6 DOTS entries:

    DT.315565  DT.91981587  DT.207655  DT.91669639  DT.100665472  DT.99933688 

    Selected AceView cDNA sequences (see all 132):

    BQ953977 AW340324 AI216469 BQ642921 AI457281 BQ215477 BC001670 BX281437 
    BC010115 AI468916 AA863340 BF899604 CR600005 AI354789 AA256529 BG257780 
    BF224181 BX328036 AA664465 AA862270 BQ232274 AA805688 AU118654 AI559548 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for FLI1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
    SP1:                                      -                 -                                       
    SP2:                          -           -                 -                                       
    SP3:        -                 -           -                                                         
    SP4:                                                                                                
    SP5:                          -                                                                     


    ECgene alternative splicing isoforms for FLI1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FLI1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTAAAATA
    FLI1 Expression
    About this image


    FLI1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Primitive Heart Tube Cells Primitive Heart Tube
             Heart Tube
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Kidney (Urinary System)
             S-shaped Body
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
    FLI1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FLI1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.504281
        Custom PCR Arrays for FLI1
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLI1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FLI1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fli11 , 5 Friend leukemia integration 11, 5 90.93(n)1
    96.68(a)1
      9 (17.74 cM)5
    142471  NM_008026.41  NP_032052.11 
     324222045 
    chicken
    (Gallus gallus)
    Aves FLI11 Friend leukemia virus integration 1 82.67(n)
    91.38(a)
      419723  NM_001030908.1  NP_001026079.1 
    lizard
    (Anolis carolinensis)
    Reptilia FLI16
    Fli-1 proto-oncogene, ETS transcription factor
    87(a)
    1 ↔ 1
    GL343197.1(4343646-4401011)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.11842 X.laevis mRNA XLFLI 78.29(n)    X66979.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fli12 friend leukemia integration 1 80.09(n)   30619  BC056588.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ets65A3 DNA binding 61(a)
    (best of 2)
      65A6   --


    ENSEMBL Gene Tree for FLI1 (if available)
    TreeFam Gene Tree for FLI1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FLI1 gene
    ETV12  ETV32  ERF2  ETV52  ETV3L2  ETS12  GABPA2  ETS22  
    ERG2  FEV2  ETV42  ETV22  
    3 SIMAP similar genes for FLI1 using alignment to 5 protein entries:     FLI1_HUMAN (see all proteins):
    ERG    EWSR1/FLI1 fusion    FEV

    Find genes that share paralogs with FLI1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FLI1 (see all 2892)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs112972511,2
    C--124512690(+) GGCGAC/-CCTCC 4 -- int11Minor allele frequency- -:0.00NA 2
    rs112972521,2
    C--124512708(+) CCCAG-/CCCCCA 4 -- int10--------
    rs112972531,2
    C--124512721(+) TGGAGC/-CCCGG 4 -- int12Minor allele frequency- -:0.00NA 4
    rs112972541,2
    C--124512726(+) CCCGGC/-CCCCC 4 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs781443481,2
    C--124512750(+) CCGCC-/GGGGCT 4 -- int10--------
    rs723233731,2
    C--124572310(+) GGGGA-/TGTG  
            
    TGTGT
    4 -- int10--------
    rs354031291,2
    C--124595398(+) CCTGG-/AAAAAA 4 -- int11Minor allele frequency- A:0.00CSA 2
    rs356234901,2
    C--124598653(+) AAAAA-/ATAAAT 4 -- int11Minor allele frequency- A:0.50CSA 2
    rs32168141,2
    C--124600215(+) CCAAAG/-ATTTT 4 -- int13Minor allele frequency- -:0.17NA CSA 6
    rs344127021,2
    C--124602890(+) AGAGC-/TGTGTGT 4 -- int10--------

    HapMap Linkage Disequilibrium report for FLI1 (128556430 - 128683162 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FLI1 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv994512CNV Deletion20482838
    nsv820393CNV Deletion20802225
    esv2666423CNV Deletion23128226
    esv2745240CNV Deletion23290073
    nsv543CNV Insertion18451855
    nsv545CNV Loss18451855
    nsv38628CNV Loss16902084
    nsv468891CNV Loss19166990
    nsv526725CNV Loss19592680
    dgv250n67CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FLI1
    DNA2.0 Custom Variant and Variant Library Synthesis for FLI1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 193067    OMIM disorders: --

    UniProtKB/Swiss-Prot: FLI1_HUMAN, Q01543
  • Ewing sarcoma (ES) [MIM:612219]: A highly malignant, metastatic, primitive small round cell tumor of bone
    and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group
    of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural
    tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the
    tumors. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration
    involving FLI1 is found in patients with Erwing sarcoma. Translocation t(11;22)(q24;q12) with EWSR1

  • 13 diseases for FLI1:    
    About MalaCards
    isolated delta-storage pool disease    paris-trousseau thrombocytopenia    horner's syndrome    connective tissue benign neoplasm
    peripheral primitive neuroectodermal tumor    kaposiform hemangioendothelioma    extraskeletal ewing sarcoma    jacobsen syndrome
    melanoma of soft parts    ewing's family of tumors    sarcoma    lymphoblastic leukemia
    leukemia

    6 diseases from the University of Copenhagen DISEASES database for FLI1:
    Peripheral primitive neuroectodermal tumor     Sarcoma     Primitive neuroectodermal tumor     Synovial sarcoma
    Rhabdomyosarcoma     Connective tissue benign neoplasm

    Find genes that share disorders with FLI1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for FLI1 gene (see all 33)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ewings sarcoma 93.4 78 12522555 (4), 16837212 (3), 8039423 (3), 16865286 (2) (see all 58)
    friend leukemia 83.5 5 15557108 (1), 18785112 (1), 19349856 (1), 1406633 (1) (see all 5)
    peripheral neuroepithelioma 75.2 1 8039423 (1)
    erythroleukemia 71.5 27 2044959 (4), 19282832 (4), 8502483 (4), 8336942 (2) (see all 14)
    neuroectodermal tumors 69.7 1 16046110 (1)
    vascular neoplasms 63.9 6 15001993 (3), 11474291 (2)
    sarcoma synovial 56.4 1 11117787 (1)
    leukemia 51.3 20 9178886 (2), 2044959 (2), 10772879 (2), 8336942 (2) (see all 15)
    rhabdomyosarcoma 50.5 2 11117787 (1), 16917000 (1)
    sarcoma 49.4 2 11474291 (1), 8336942 (1)

    Genetic Association Database (GAD): FLI1
    Human Genome Epidemiology (HuGE) Navigator: FLI1 (7 documents)
    Tumor Gene Database (TGDB): FLI1

    Export disorders for FLI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FLI1 gene, integrated from 10 sources (see all 253):
    (articles sorted by number of sources associating them with FLI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human homolog of the mouse common viral integration region, FLI1, maps to 11q23-q24. (PubMed id 1765382)1, 2, 3 Baud V.... Bergeron D. (Genomics 1991)
    2. Solution structure of the ets domain of Fli-1 when bound to DNA. (PubMed id 7773776)1, 2, 9 Liang H.... Fesik S.W. (Nat. Struct. Biol. 1994)
    3. Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. (PubMed id 18174230)1, 4, 9 Miyagawa H....Horiuchi T. (Rheumatology (Oxford) 2008)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Chromosome translocation based on illegitimate recombination in human tumors. (PubMed id 9751743)1, 2 Zucman-Rossi J.... Thomas G. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    7. Molecular analysis of a t(11;22) translocation junction in a case of Ewing's sarcoma. (PubMed id 7542907)1, 2 Bhagirath T.... Yoshida M.C. (Genes Chromosomes Cancer 1995)
    8. Human FLI-1 localizes to chromosome 11q24 and has an aberrant transcript in neuroepithelioma. (PubMed id 8439553)1, 2 Hromas R....Klemsz M.J. (Biochim. Biophys. Acta 1993)
    9. Structure and expression of human Fli-1 gene. (PubMed id 1394211)1, 2 Prasad D.D.... Reddy E.S. (Cancer Res. 1992)
    10. The ERGB/Fli-1 gene: isolation and characterization of a new member of the family of human ETS transcription factors. (PubMed id 1445800)1, 2 Watson D.K.... Seth A. (Cell Growth Differ. 1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2313 HGNC: 3749 AceView: FLI1 Ensembl:ENSG00000151702 euGenes: HUgn2313
    ECgene: FLI1 Kegg: 2313 H-InvDB: FLI1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FLI1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FLI1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FLI1 gene:
    Search GeneIP for patents involving FLI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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