Aliases for FLI1 Gene
External Ids for FLI1 Gene
This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
GeneCards Summary for FLI1 Gene
FLI1 (Fli-1 Proto-Oncogene, ETS Transcription Factor) is a Protein Coding gene. Diseases associated with FLI1 include peripheral primitive neuroectodermal tumor and isolated delta-storage pool disease. Among its related pathways are Transcriptional misregulation in cancer and Lymphocyte Signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and RNA polymerase II distal enhancer sequence-specific DNA binding. An important paralog of this gene is ETV2.
UniProtKB/Swiss-Prot for FLI1 Gene
Sequence-specific transcriptional activator. Recognizes the DNA sequence 5-C[CA]GGAAGT-3