FLG2 Gene
protein-coding GIFtS: 46
GCID: GC01M152321
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filaggrin family member 2
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Aliases
for FLG2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Filaggrin Family Member 21 2 | | Filaggrin-21 | | IFPS1 2 3 | | Ifapsoriasin3 | | Intermediate Filament-Associated And Psoriasis-Susceptibility Protein2 3 | | Intermediate Filament-Associated And Psoriasis Susceptibility Protein2 | | FLG-22 3 | | Ifapsoriasin3 | | Filaggrin 22 | | |
Export aliases for FLG2 gene to outside databasesPrevious GC identifers: GC01M150588 GC01M123694 |
Summaries
for FLG2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FLG2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FLG2 gene promoter:
ISGF-3 AML1a NF-YA CBF-C CBF-A CBF-B CP1A CP1C NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for FLG2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FLG2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21.3 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21.3FLG2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M152321: view genomic region
(about GC identifiers)
Start:
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152,321,213 bp from pter |
End:
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152,332,482 bp from pter |
Size:
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11,270 bases |
Orientation:
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minus strand |
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Proteins
for FLG2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FILA2_HUMAN, Q5D862 (See
protein sequence)Recommended Name: Filaggrin-2 Size: 2391 amino acids; 248073 Da
Secondary accessions: Q9H4U1Explore the universe of human proteins at neXtProt for FLG2: NX_Q5D862
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5D862
FLG2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001014364.1
ENSEMBL proteins: ENSP00000373370
Human Recombinant Protein Products:
FLG2 Antibody Products:
Assay Products for FLG2: |
Protein
Domains /
Families
for FLG2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FLG2 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q5D862ProtoNet protein and cluster: Q5D862 2 Blocks protein families: IPB001254 Serine protease IPB001751 Calcium-binding protein
UniProtKB/Swiss-Prot: FILA2_HUMAN, Q5D862Similarity: Belongs to the S100-fused protein familySimilarity: In the N-terminal section; belongs to the S-100 familySimilarity: Contains 2 EF-hand domainsSimilarity: Contains 10 filaggrin repeats |
Function
for FLG2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FLG2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FLG2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FLG2 (NM_001014342) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FLG2 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FLG2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLG2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005198 | structural molecule activity |
IEA | -- | | GO:0005509 | calcium ion binding |
IEA | -- |
FLG2 for ontologies About GeneDecksing
|
Pathways & Interactions
for FLG2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FLG2
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/142 Interacting proteins for FLG2 (Q5D8622, 3 ENSP000003733704) via UniProtKB, MINT, STRING, and/or I2D (see all 142)About this table
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Drugs & Compounds
for FLG2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FLG2
Search CenterWatch for drugs/clinical trials and news about FLG2 / FILA2
|
Transcripts
for FLG2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FLG2 gene: NM_001014342.2 Unigene Cluster for FLG2: Filaggrin family member 2 Hs.156124 [show with all ESTs]Unigene Representative Sequence: NM_0010143421 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000388718(uc001ezw.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FLG2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FLG2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FLG2 (NM_001014342) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FLG2 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FLG2 |
Additional cDNA sequence: AY827490.1 BC029685.1 BC063543.1 BC108269.1 1 DOTS entry: DT.101975905 2 AceView cDNA sequences: AI332653 BX095286
GeneLoc Exon Structure
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Expression
for FLG2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FLG2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCTTCTGGA
About this image
See FLG2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FLG2
SOURCE GeneReport for Unigene cluster: Hs.156124
SABiosciences Custom PCR Arrays for FLG2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FLG2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FLG2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FLG2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FLG2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLG2 |
Orthologs
for FLG2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FLG2 gene from 1/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
TCHHL16 |
-- |
14(a) |
1 → many |
GL343369.1(7-2795) |
ENSEMBL Gene Tree for FLG2 (if available)
TreeFam Gene Tree for FLG2 (if available) |
Paralogs
for FLG2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FLG2 gene
- RPTN2 FLG2 CRNN2 HRNR2 TCHHL12
11 SIMAP similar genes for FLG2 using alignment to 2 protein entries: FILA2_HUMAN (see all proteins):S100A9 S100B S100A12 S100A2 S100P S100Z
S100A10 HRNR FLG S100A8 S100A11
FLG2 for paralogs About GeneDecksing
|
Genomic Variants
for FLG2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FLG2
1 CNV: 97510
1 Indel: 44451 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FLG2 |
|
Disorders
/ Diseases
for FLG2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FLG2 for disorders About GeneDecksing
11  diseases for FLG2: About MalaCardspsoriasis eczema herpeticum ichthyosis vulgaris irritant dermatitis
renal cell carcinoma intussusception atopic dermatitis dermatitis
ichthyosis eczema carcinoma
3 diseases from the University of Copenhagen DISEASES database for FLG2:Ichthyosis vulgaris Eczema herpeticum Atopic dermatitis Human Genome Epidemiology (HuGE) Navigator: FLG2 (1 document)
Export disorders for FLG2 gene to outside databases
|
Publications
for FLG2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FLG2 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with FLG2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Molecular identification and expression analysis of filaggrin-2, a member of the S100 fused-type protein family. (PubMed id 19384417)1, 9 Wu Z....SchrAPder J.M. (2009)
- Biochemical and phosphoproteomic analysis of the helix -loop-helix protein E47. (PubMed id 22354994)1 Teachenor R....Murre C. (2012)
- An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (2011)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Deimination of human filaggrin-2 promotes its proteol ysis by calpain 1. (PubMed id 21531719)1 Hsu C.Y....Simon M. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Variation in genes of the epidermal differentiation c omplex in German atopic dermatitis patients. (PubMed id 19601998)1 Stemmler S....Hoffjan S. (2009)
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External Searches for FLG2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing FLG2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FLG2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FLG2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FLG2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for FLG2 gene:
Search GeneIP for patents involving FLG2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FLG2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FLG2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FLG2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FLG2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FLG2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FLG2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FLG2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FLG2 | | OriGene Custom Protein Services for FLG2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FLG2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FLG2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FLG2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FLG2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FLG2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FLG2 |
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| | | | Search Tocris compounds for FLG2 |
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 | | | FLG2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FLG2 |
|  |  |  | | | | Search ThermoFisher Antibodies for FLG2 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FLG2 |
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