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Aliases for FLCN Gene

Aliases for FLCN Gene

  • Folliculin 2 3
  • BHD 3 4 6
  • BHD Skin Lesion Fibrofolliculoma Protein 3 4
  • Birt-Hogg-Dube Syndrome Protein 3 4
  • FLCL 3

External Ids for FLCN Gene

Summaries for FLCN Gene

Entrez Gene Summary for FLCN Gene

  • This gene is located within the Smith-Magenis syndrome region on chromosome 17. Mutations in this gene are associated with Birt-Hogg-Dube syndrome, which is characterized by fibrofolliculomas, renal tumors, lung cysts, and pneumothorax. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for FLCN Gene

FLCN (Folliculin) is a Protein Coding gene. Diseases associated with FLCN include pneumothorax and birt-hogg-dube syndrome. Among its related pathways are Translational Control and Development HGF signaling pathway. GO annotations related to this gene include protein complex binding. An important paralog of this gene is ENSG00000264187.

UniProtKB/Swiss-Prot for FLCN Gene

  • May play a role in the pathogenesis of an uncommon form of kidney cancer through its association with an inherited disorder of the hair follicle (fibrofolliculomas). May be a tumor suppressor. May be involved in colorectal tumorigenesis. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLCN Gene

Genomics for FLCN Gene

Genomic Location for FLCN Gene

Start:
17,212,209 bp from pter
End:
17,237,190 bp from pter
Size:
24,982 bases
Orientation:
Minus strand

Genomic View for FLCN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FLCN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FLCN Gene

Regulatory Elements for FLCN Gene

Proteins for FLCN Gene

  • Protein details for FLCN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFG4-FLCN_HUMAN
    Recommended name:
    Folliculin
    Protein Accession:
    Q8NFG4
    Secondary Accessions:
    • A6NJJ8
    • Q6ZRX1
    • Q96BD2
    • Q96BE4

    Protein attributes for FLCN Gene

    Size:
    579 amino acids
    Molecular mass:
    64473 Da
    Quaternary structure:
    • Interacts (via C-terminus) with FNIP1 and FNIP2 (via C-terminus). This mediates indirect interaction with the PRKAA1, PRKAB1 and PRKAG1 subunits of 5-AMP-activated protein kinase.

    Three dimensional structures from OCA and Proteopedia for FLCN Gene

    Alternative splice isoforms for FLCN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FLCN Gene

Proteomics data for FLCN Gene at MOPED

Post-translational modifications for FLCN Gene

  • Phosphorylated. Several different phosphorylated forms exist.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys206 and Lys559

Other Protein References for FLCN Gene

No data available for DME Specific Peptides for FLCN Gene

Domains for FLCN Gene

Protein Domains for FLCN Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

FLCN_HUMAN
Family:
  • Belongs to the folliculin family.:
    • Q8NFG4
genes like me logo Genes that share domains with FLCN: view

No data available for Gene Families for FLCN Gene

Function for FLCN Gene

Molecular function for FLCN Gene

UniProtKB/Swiss-Prot Function: May play a role in the pathogenesis of an uncommon form of kidney cancer through its association with an inherited disorder of the hair follicle (fibrofolliculomas). May be a tumor suppressor. May be involved in colorectal tumorigenesis. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.

Gene Ontology (GO) - Molecular Function for FLCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17028174
GO:0032403 protein complex binding IDA 17028174
genes like me logo Genes that share ontologies with FLCN: view
genes like me logo Genes that share phenotypes with FLCN: view

Animal Models for FLCN Gene

MGI Knock Outs for FLCN:

miRNA for FLCN Gene

miRTarBase miRNAs that target FLCN

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FLCN Gene

Localization for FLCN Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLCN Gene

Cytoplasm. Nucleus. Note=Mainly localized in the nucleus. Colocalizes with FNIP1 and FNIP2 in the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FLCN Gene COMPARTMENTS Subcellular localization image for FLCN gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 3
extracellular 1
golgi apparatus 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FLCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17028174
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
GO:0030496 colocalizes_with midbody IDA 22965878
GO:0044291 colocalizes_with cell-cell contact zone IDA 22965878
genes like me logo Genes that share ontologies with FLCN: view

Pathways for FLCN Gene

genes like me logo Genes that share pathways with FLCN: view

Pathways by source for FLCN Gene

1 Cell Signaling Technology pathway for FLCN Gene
1 KEGG pathway for FLCN Gene

Gene Ontology (GO) - Biological Process for FLCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 21209915
GO:0001701 in utero embryonic development ISS --
GO:0001932 regulation of protein phosphorylation IDA 18663353
GO:0001934 positive regulation of protein phosphorylation ISS --
GO:0007043 cell-cell junction assembly ISS --
genes like me logo Genes that share ontologies with FLCN: view

Compounds for FLCN Gene

(1) Novoseek inferred chemical compound relationships for FLCN Gene

Compound -log(P) Hits PubMed IDs
rapamycin 48.7 8
genes like me logo Genes that share compounds with FLCN: view

Transcripts for FLCN Gene

Unigene Clusters for FLCN Gene

Folliculin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FLCN Gene

No ASD Table

Relevant External Links for FLCN Gene

GeneLoc Exon Structure for
FLCN
ECgene alternative splicing isoforms for
FLCN

Expression for FLCN Gene

mRNA expression in normal human tissues for FLCN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FLCN Gene

SOURCE GeneReport for Unigene cluster for FLCN Gene Hs.31652

mRNA Expression by UniProt/SwissProt for FLCN Gene

Q8NFG4-FLCN_HUMAN
Tissue specificity: Expressed in most tissues tested, including skin, lung, kidney, heart, testis and stomach.
genes like me logo Genes that share expressions with FLCN: view

Orthologs for FLCN Gene

This gene was present in the common ancestor of animals.

Orthologs for FLCN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FLCN 36
  • 99.89 (n)
  • 99.66 (a)
cow
(Bos Taurus)
Mammalia FLCN 36
  • 87.62 (n)
  • 92.4 (a)
FLCN 37
  • 92 (a)
OneToMany
dog
(Canis familiaris)
Mammalia FLCN 36
  • 88.66 (n)
  • 94.47 (a)
FLCN 37
  • 94 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Flcn 36
  • 87.39 (n)
  • 92.57 (a)
Flcn 16
Flcn 37
  • 93 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 90 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 92 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Flcn 36
  • 86.59 (n)
  • 92.75 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 88 (a)
OneToMany
FLCN 36
  • 78.74 (n)
  • 88.39 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 73 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia flcn 36
  • 76.03 (n)
  • 82.32 (a)
zebrafish
(Danio rerio)
Actinopterygii flcn 36
  • 63.73 (n)
  • 65.87 (a)
flcn 37
  • 64 (a)
OneToMany
wufe38g11 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007579 36
  • 47.28 (n)
  • 34.98 (a)
fruit fly
(Drosophila melanogaster)
Insecta BHD 36
  • 45.89 (n)
  • 32.38 (a)
BHD 37
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F22D3.2 36
  • 40.76 (n)
  • 29.33 (a)
flcn-1 37
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2717 37
  • 43 (a)
OneToMany
Species with no ortholog for FLCN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FLCN Gene

ENSEMBL:
Gene Tree for FLCN (if available)
TreeFam:
Gene Tree for FLCN (if available)

Paralogs for FLCN Gene

Paralogs for FLCN Gene

genes like me logo Genes that share paralogs with FLCN: view

Variants for FLCN Gene

Sequence variations from dbSNP and Humsavar for FLCN Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1613416 -- 17,229,807(-) TGCCA(C/T)GGAAA intron-variant
rs1708617 -- 17,229,304(-) GTGAC(C/T)CTGGA intron-variant
rs1708618 -- 17,228,555(-) AGCAG(A/G)TATGT intron-variant
rs1708619 -- 17,226,729(-) CTGGG(A/G)GCAGT intron-variant
rs1708620 -- 17,226,610(-) GGGTG(A/G)CACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FLCN Gene

Variant ID Type Subtype PubMed ID
nsv155 OTHER Inversion 15895083
nsv499114 OTHER Inversion 21111241
nsv833380 CNV Loss 17160897
nsv833382 CNV Loss 17160897
nsv469777 CNV Complex 16826518
esv1004208 CNV Deletion 20482838

Relevant External Links for FLCN Gene

HapMap Linkage Disequilibrium report
FLCN
Human Gene Mutation Database (HGMD)
FLCN
Locus Specific Mutation Databases (LSDB)
FLCN

Disorders for FLCN Gene

(4) OMIM Diseases for FLCN Gene (607273)

UniProtKB/Swiss-Prot

FLCN_HUMAN
  • Birt-Hogg-Dube syndrome (BHD) [MIM:135150]: A rare autosomal dominant genodermatosis characterized by hair follicle hamartomas (fibrofolliculomas), kidney tumors, and spontaneous pneumothorax. Fibrofolliculomas are part of the triad of Birt-Hogg-Dube syndrome skin lesions that also includes trichodiscomas and acrochordons. Onset of this dermatologic condition is invariably in adulthood. Birt-Hogg-Dube syndrome is associated with a variety of histologic types of renal tumors, including chromophobe renal cell carcinoma (RCC), benign renal oncocytoma, clear-cell RCC and papillary type I RCC. Multiple lipomas, angiolipomas, and parathyroid adenomas are also seen in Birt-Hogg-Dube syndrome patients. {ECO:0000269 PubMed:12204536, ECO:0000269 PubMed:15852235, ECO:0000269 PubMed:18234728, ECO:0000269 PubMed:19785621}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Primary spontaneous pneumothorax (PSP) [MIM:173600]: Condition in which air is present in the pleural space in the absence of a precipitating event, such as trauma or lung disease. This results in secondary collapse of the lung, either partially or completely, and some degree of hypoxia. PSP is relatively common, with an incidence between 7.4-18/100000 for men and 1.2-6/100000 for women and a dose-dependent, increased risk among smokers. Most cases are sporadic, typically occurring in tall, thin men aged 10-30 years and generally while at rest. Familial PSP is rarer and usually is inherited as an autosomal dominant condition with reduced penetrance, although X-linked recessive and autosomal recessive inheritance have also been suggested. {ECO:0000269 PubMed:15657874, ECO:0000269 PubMed:18505456, ECO:0000269 PubMed:18579543}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Renal cell carcinoma (RCC) [MIM:144700]: Renal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Clear cell renal cell carcinoma is the most common subtype. {ECO:0000269 PubMed:18794106}. Note=The gene represented in this entry may be involved in disease pathogenesis.

(5) University of Copenhagen DISEASES for FLCN Gene

(17) Novoseek inferred disease relationships for FLCN Gene

Disease -log(P) Hits PubMed IDs
birt-hogg-dube syndrome 95.8 3
spontaneous pneumothorax 90.1 20
kidney tumor 89.3 12
oncocytoma 83.5 7
renal cancer 78.1 8

Relevant External Links for FLCN

GeneTests
FLCN
GeneReviews
FLCN
Genetic Association Database (GAD)
FLCN
Human Genome Epidemiology (HuGE) Navigator
FLCN
genes like me logo Genes that share disorders with FLCN: view

Publications for FLCN Gene

  1. Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. (PMID: 17028174) Baba M. … Zbar B. (Proc. Natl. Acad. Sci. U.S.A. 2006) 2 3 4 23
  2. Mutation analysis of the FLCN gene in Chinese patients with sporadic and familial isolated primary spontaneous pneumothorax. (PMID: 18505456) Ren H.Z. … Yi L. (Clin. Genet. 2008) 3 4 23 49
  3. BHD mutations, clinical and molecular genetic investigations of Birt- Hogg-Dube syndrome: a new series of 50 families and a review of published reports. (PMID: 18234728) Toro J.R. … Linehan W.M. (J. Med. Genet. 2008) 3 4 23
  4. Identification and characterization of a novel folliculin-interacting protein FNIP2. (PMID: 18403135) Hasumi H. … Schmidt L.S. (Gene 2008) 3 4 23
  5. Germline BHD-mutation spectrum and phenotype analysis of a large cohort of families with Birt-Hogg-Dube syndrome. (PMID: 15852235) Schmidt L.S. … Linehan W.M. (Am. J. Hum. Genet. 2005) 3 4 23

Products for FLCN Gene

Sources for FLCN Gene

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