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Aliases for FLAD1 Gene

Aliases for FLAD1 Gene

  • Flavin Adenine Dinucleotide Synthetase 1 2 3
  • FMN Adenylyltransferase 3 4
  • FAD Pyrophosphorylase 3 4
  • EC 2.7.7.2 4 63
  • FAD1 Flavin Adenine Dinucleotide Synthetase Homolog (S. Cerevisiae) 2
  • Fad1, Flavin Adenine Dinucleotide Synthetase, Homolog (Yeast) 2
  • Fad1, Flavin Adenine Dinucleotide Synthetase, Homolog 3
  • Flavin Adenine Dinucleotide Synthetase 2
  • Flavin Adenine Dinucleotide Synthase 4
  • FAD-Synthetase 3
  • EC 2.7.7 63
  • PP591 3
  • FADS 3
  • FAD1 3

External Ids for FLAD1 Gene

Previous GeneCards Identifiers for FLAD1 Gene

  • GC01P151769
  • GC01P153222
  • GC01P154955
  • GC01P126317

Summaries for FLAD1 Gene

Entrez Gene Summary for FLAD1 Gene

  • This gene encodes the enzyme that catalyzes adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for FLAD1 Gene

FLAD1 (Flavin Adenine Dinucleotide Synthetase 1) is a Protein Coding gene. Diseases associated with FLAD1 include myasthenic syndrome, congenital, 9, associated with acetylcholine receptor deficiency and myasthenic syndrome, congenital, 11, associated with acetylcholine receptor deficiency. Among its related pathways are Metabolism and Selenium Pathway. GO annotations related to this gene include FMN adenylyltransferase activity.

UniProtKB/Swiss-Prot for FLAD1 Gene

  • Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLAD1 Gene

Genomics for FLAD1 Gene

Regulatory Elements for FLAD1 Gene

Genomic Location for FLAD1 Gene

Chromosome:
1
Start:
154,983,294 bp from pter
End:
154,993,111 bp from pter
Size:
9,818 bases
Orientation:
Plus strand

Genomic View for FLAD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FLAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FLAD1 Gene

Proteins for FLAD1 Gene

  • Protein details for FLAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFF5-FAD1_HUMAN
    Recommended name:
    FAD synthase
    Protein Accession:
    Q8NFF5
    Secondary Accessions:
    • Q8N5J1
    • Q8N686
    • Q8WU93
    • Q8WUJ4
    • Q96CR8
    • Q99764
    • Q9HBN6

    Protein attributes for FLAD1 Gene

    Size:
    587 amino acids
    Molecular mass:
    65266 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FLAD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FLAD1 Gene

Proteomics data for FLAD1 Gene at MOPED

Selected DME Specific Peptides for FLAD1 Gene

Post-translational modifications for FLAD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for FLAD1 Gene

Protein Domains for FLAD1 Gene

Suggested Antigen Peptide Sequences for FLAD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NFF5

UniProtKB/Swiss-Prot:

FAD1_HUMAN :
  • The molybdenum cofactor biosynthesis protein-like region may not be functional
  • In the N-terminal section; belongs to the MoaB/Mog family.
Domain:
  • The molybdenum cofactor biosynthesis protein-like region may not be functional
Family:
  • In the N-terminal section; belongs to the MoaB/Mog family.
  • In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.
genes like me logo Genes that share domains with FLAD1: view

No data available for Gene Families for FLAD1 Gene

Function for FLAD1 Gene

Molecular function for FLAD1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.5 uM for FMN {ECO:0000269 PubMed:16643857, ECO:0000269 PubMed:17049878}; KM=0.36 uM for FMN (isoform 2) {ECO:0000269 PubMed:16643857, ECO:0000269 PubMed:17049878}; Vmax=6.1 nmol/min/mg enzyme {ECO:0000269 PubMed:16643857, ECO:0000269 PubMed:17049878}; Vmax=3.9 nmol/min/mg enzyme (isoform 2) {ECO:0000269 PubMed:16643857, ECO:0000269 PubMed:17049878};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + FMN = diphosphate + FAD.
UniProtKB/Swiss-Prot Function:
Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme

Enzyme Numbers (IUBMB) for FLAD1 Gene

Gene Ontology (GO) - Molecular Function for FLAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0003919 FMN adenylyltransferase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with FLAD1: view

Phenotypes for FLAD1 Gene

GenomeRNAi human phenotypes for FLAD1:
genes like me logo Genes that share phenotypes with FLAD1: view

Animal Model Products

miRNA for FLAD1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FLAD1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for FLAD1 Gene

Localization for FLAD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLAD1 Gene

Isoform 1: Mitochondrion matrix.
Isoform 2: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FLAD1 Gene COMPARTMENTS Subcellular localization image for FLAD1 gene
Compartment Confidence
mitochondrion 5
cytosol 4
plasma membrane 4
chloroplast 1
endoplasmic reticulum 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FLAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005759 mitochondrial matrix IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with FLAD1: view

Pathways & Interactions for FLAD1 Gene

genes like me logo Genes that share pathways with FLAD1: view

Pathways by source for FLAD1 Gene

UniProtKB/Swiss-Prot Q8NFF5-FAD1_HUMAN

  • Pathway: Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1

Gene Ontology (GO) - Biological Process for FLAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006747 FAD biosynthetic process IEA --
GO:0006766 vitamin metabolic process TAS --
GO:0006767 water-soluble vitamin metabolic process TAS --
GO:0006771 riboflavin metabolic process TAS --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with FLAD1: view

No data available for SIGNOR curated interactions for FLAD1 Gene

Drugs & Compounds for FLAD1 Gene

(6) Drugs for FLAD1 Gene - From: HMDB and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Adenosine triphosphate Approved Nutra 0
Riboflavin Approved Nutra 138
Flavin Mononucleotide Experimental Pharma 5
Diphosphate Experimental Pharma 0

(3) Additional Compounds for FLAD1 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
flavin
FLAVIN-ADENINE DINUCLEOTIDE
genes like me logo Genes that share compounds with FLAD1: view

Transcripts for FLAD1 Gene

Unigene Clusters for FLAD1 Gene

Flavin adenine dinucleotide synthetase 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FLAD1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FLAD1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - -
SP9: -
SP10: - -
SP11: - - - -
SP12: - -
SP13: - -
SP14: - - -
SP15: - - - - - -
SP16: - - - - -
SP17: - - -

ExUns: 12 ^ 13a · 13b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for FLAD1 Gene

GeneLoc Exon Structure for
FLAD1
ECgene alternative splicing isoforms for
FLAD1

Expression for FLAD1 Gene

mRNA expression in normal human tissues for FLAD1 Gene

Protein differential expression in normal tissues from HIPED for FLAD1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.0), Bone (13.1), and Salivary gland (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FLAD1 Gene



SOURCE GeneReport for Unigene cluster for FLAD1 Gene Hs.118666

genes like me logo Genes that share expression patterns with FLAD1: view

Protein tissue co-expression partners for FLAD1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FLAD1 Gene

Orthologs for FLAD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FLAD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FLAD1 35
  • 88.98 (n)
  • 92.24 (a)
FLAD1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FLAD1 35
  • 88.1 (n)
  • 91.84 (a)
FLAD1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Flad1 35
  • 86.23 (n)
  • 89.98 (a)
Flad1 16
Flad1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FLAD1 35
  • 99.52 (n)
  • 99.39 (a)
FLAD1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Flad1 35
  • 86.84 (n)
  • 90.18 (a)
oppossum
(Monodelphis domestica)
Mammalia FLAD1 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FLAD1 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves FLAD1 35
  • 64.17 (n)
  • 62.96 (a)
FLAD1 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FLAD1 36
  • 61 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii Dr.27212 35
flad1 35
  • 58.98 (n)
  • 58.28 (a)
flad1 36
  • 56 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1643 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002740 35
  • 53.33 (n)
  • 47.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4407 35
  • 51.69 (n)
  • 42.78 (a)
CG16848 36
  • 41 (a)
OneToMany
CG4407 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea flad-1 35
  • 47.1 (n)
  • 40.68 (a)
flad-1 36
  • 36 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER198W 35
  • 45.94 (n)
  • 35.75 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E13377g 35
  • 44.96 (n)
  • 40.7 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAD1 35
  • 45.77 (n)
  • 37.81 (a)
FAD1 36
  • 25 (a)
OneToOne
FAD1 38
bread mold
(Neurospora crassa)
Ascomycetes NCU09233 35
  • 50.3 (n)
  • 43.64 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC1235.04c 35
  • 46.03 (n)
  • 41.43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10620 36
  • 44 (a)
OneToOne
Species with no ortholog for FLAD1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FLAD1 Gene

ENSEMBL:
Gene Tree for FLAD1 (if available)
TreeFam:
Gene Tree for FLAD1 (if available)

Paralogs for FLAD1 Gene

No data available for Paralogs for FLAD1 Gene

Variants for FLAD1 Gene

Sequence variations from dbSNP and Humsavar for FLAD1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1054257 -- 154,984,004(+) CCTCT(A/G)AACTT missense, reference, utr-variant-5-prime, intron-variant, nc-transcript-variant
rs1054276 -- 154,988,750(+) GCTTG(C/G)CCTAC missense, reference, nc-transcript-variant
rs2089247 -- 154,988,972(+) TTCTG(G/T)TAATT intron-variant, utr-variant-3-prime
rs2089248 -- 154,989,230(+) ATTTG(A/G)TCAGT intron-variant, downstream-variant-500B
rs2292246 -- 154,983,472(+) CAGAA(G/T)CCTGA intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FLAD1 Gene

Variant ID Type Subtype PubMed ID
nsv509502 CNV Insertion 20534489
nsv872453 CNV Loss 21882294
nsv872454 CNV Loss 21882294

Variation tolerance for FLAD1 Gene

Residual Variation Intolerance Score: 34.74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.00; 36.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FLAD1 Gene

HapMap Linkage Disequilibrium report
FLAD1
Human Gene Mutation Database (HGMD)
FLAD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLAD1 Gene

Disorders for FLAD1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for FLAD1 Gene - From: OMIM, DISEASES, and GeneCards

Relevant External Links for FLAD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FLAD1
genes like me logo Genes that share disorders with FLAD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FLAD1 Gene

Publications for FLAD1 Gene

  1. Mitochondrial localization of human FAD synthetase isoform 1. (PMID: 20060505) Torchetti E.M. … Barile M. (Mitochondrion 2010) 23 67
  2. A bifunctional molecule as an artificial flavin mononucleotide cyclase and a chemosensor for selective fluorescent detection of flavins. (PMID: 19569646) Rhee H.W. … Hong J.I. (J. Am. Chem. Soc. 2009) 23 67
  3. Specific electron transport chain abnormalities in amyotrophic lateral sclerosis. (PMID: 19240958) Lin J. … Sadiq S.A. (J. Neurol. 2009) 23 67
  4. [Comparative proteomics of the serum in patients with nasopharyngeal carcinoma: a study with two-dimensional electrophoresis and MALDI-TOF-MS]. (PMID: 18250030) Liao Q.L. … Ding Y.Q. (Nan Fang Yi Ke Da Xue Xue Bao 2008) 23 67
  5. Over-expression in Escherichia coli, purification and characterization of isoform 2 of human FAD synthetase. (PMID: 17049878) Galluccio M. … Barile M. (Protein Expr. Purif. 2007) 23 67

Products for FLAD1 Gene

Sources for FLAD1 Gene

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