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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FLAD1 Gene

protein-coding   GIFtS: 59
GCID: GC01P154955

Flavin Adenine Dinucleotide Synthetase 1

(Previous names: Fad1, flavin adenine dinucleotide synthetase, homolog (yeast),...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Flavin Adenine Dinucleotide Synthetase 11 2     FAD-synthetase2
Flavin Adenine Dinucleotide Synthase2 3     FAD12
FAD Pyrophosphorylase2 3     RP11-307C12.72
FMN Adenylyltransferase2 3     FAD Synthase2
EC 2.7.7.23 8     FAD Synthetase2
FADS2 5     FAD1 Flavin Adenine Dinucleotide Synthetase Homolog2
FAD1 Flavin Adenine Dinucleotide Synthetase Homolog (S. Cerevisiae)1     Fad1, Flavin Adenine Dinucleotide Synthetase, Homolog2
Fad1, Flavin Adenine Dinucleotide Synthetase, Homolog (Yeast)1     EC 2.7.78
Flavin Adenine Dinucleotide Synthetase1     

External Ids:    HGNC: 246711   Entrez Gene: 803082   Ensembl: ENSG000001606887   OMIM: 6105955   UniProtKB: Q8NFF53   

Export aliases for FLAD1 gene to outside databases

Previous GC identifers: GC01P151769 GC01P153222 GC01P126317


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FLAD1 Gene:
This gene encodes the enzyme that catalyzes adenylation of flavin mononucleotide (FMN) to form flavin adenine
dinucleotide (FAD) coenzyme. Alternatively spliced transcript variants encoding distinct isoforms have been
observed. (provided by RefSeq, Jul 2008)

GeneCards Summary for FLAD1 Gene: 
FLAD1 (flavin adenine dinucleotide synthetase 1) is a protein-coding gene. Diseases associated with FLAD1 include associative agnosia, and cholinergic urticaria, and among its related super-pathways are Metabolic pathways and Metabolism of water-soluble vitamins and cofactors. GO annotations related to this gene include FMN adenylyltransferase activity and ATP binding.

UniProtKB/Swiss-Prot: FAD1_HUMAN, Q8NFF5
Function: Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD)
coenzyme




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FLAD1 gene promoter:
         CREB   AP-1   deltaCREB   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFLAD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for FLAD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FLAD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q22

FLAD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FLAD1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P154955:  view genomic region     (about GC identifiers)

Start:
154,955,770 bp from pter      End:
154,965,587 bp from pter
Size:
9,818 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FAD1_HUMAN, Q8NFF5 (See protein sequence)
Recommended Name: FAD synthase  
Size: 587 amino acids; 65266 Da
Cofactor: Magnesium
Secondary accessions: Q8N5J1 Q8N686 Q8WU93 Q8WUJ4 Q96CR8 Q99764 Q9HBN6
Alternative splicing: 5 isoforms:  Q8NFF5-1   Q8NFF5-2   Q8NFF5-3   Q8NFF5-4   Q8NFF5-5   

Explore the universe of human proteins at neXtProt for FLAD1: NX_Q8NFF5

Explore proteomics data for FLAD1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NFF5

  • 4/5 DME Specific Peptides for FLAD1 (Q8NFF5) (see all 5)
     TSRASEL  FLQDTIKRY  GGIGPTHDDVTFE  GDEILKGHTQDTN 

    FLAD1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FLAD1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001171820.1  NP_001171821.1  NP_079483.3  NP_958800.1  

    ENSEMBL proteins: 
     ENSP00000357418   ENSP00000317296   ENSP00000357417   ENSP00000357416   ENSP00000292180  
     ENSP00000295530   ENSP00000357413   ENSP00000384323  
    Reactome Protein details: Q8NFF5
    Human Recombinant Protein Products for FLAD1: 
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    Cloud-Clone Corp. Proteins for FLAD1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    FLAD1 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for FLAD1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR012183 FAD_synth_Mopterin-bd
     IPR001453 Mopterin-bd_dom
     IPR002500 PAPS_reduct
     IPR014729 Rossmann-like_a/b/a_fold

    Graphical View of Domain Structure for InterPro Entry Q8NFF5

    ProtoNet protein and cluster: Q8NFF5

    UniProtKB/Swiss-Prot: FAD1_HUMAN, Q8NFF5
    Domain: The molybdenum cofactor biosynthesis protein-like region may not be functional
    Similarity: In the N-terminal section; belongs to the MoaB/Mog family
    Similarity: In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily


    FLAD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FAD1_HUMAN, Q8NFF5
    Function: Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD)
    coenzyme
    Catalytic activity: ATP + FMN = diphosphate + FAD
    Biophysicochemical properties: Kinetic parameters: KM=1.5 uM for FMN (PubMed:16643857); KM=0.36 uM for FMN
    (isoform 2) (PubMed:17049878); Vmax=6.1 nmol/min/mg enzyme (PubMed:16643857); Vmax=3.9 nmol/min/mg enzyme
    (isoform 2) (PubMed:17049878);

         Enzyme Numbers (IUBMB): EC 2.7.7.21 2 EC 2.7.72

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0003919FMN adenylyltransferase activity IEA--
    GO:0005524ATP binding IEA--
         
    FLAD1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FLAD1:
     Decreased viability 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FLAD1 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    2Metabolism of vitamins and cofactors
    Metabolism of water-soluble vitamins and cofactors1.00
    Metabolism of vitamins and cofactors1.00
    3Vitamin B2 (riboflavin) metabolism
    Vitamin B2 (riboflavin) metabolism
    4Selenium Pathway
    Selenium Pathway
    5Riboflavin metabolism
    Riboflavin metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for FLAD1
        Selenium Pathway
    flavin biosynthesis IV (mammalian)


    4        Reactome Pathways for FLAD1
        Metabolism
    Metabolism of vitamins and cofactors
    Metabolism of water-soluble vitamins and cofactors
    Vitamin B2 (riboflavin) metabolism


    2         Kegg Pathways  (Kegg details for FLAD1):
        Riboflavin metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: FAD1_HUMAN, Q8NFF5
    Pathway: Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1


    FLAD1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FLAD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/265 Interacting proteins for FLAD1 (Q8NFF52, 3 ENSP000002921804) via UniProtKB, MINT, STRING, and/or I2D (see all 265)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRTFDC1Q9NRG12, 3, ENSP000003186024MINT-66367 I2D: score=5 STRING: ENSP00000318602
    CDKN1AP389362, 3, ENSP000002447414MINT-8251904 I2D: score=2 STRING: ENSP00000244741
    SMN1Q166372, 3MINT-8271157 I2D: score=2 
    SMN2Q166372, 3MINT-8271157 I2D: score=2 
    ANXA7P200732, 3MINT-8248373 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006747FAD biosynthetic process IEA--
    GO:0006766vitamin metabolic process TAS--
    GO:0006767water-soluble vitamin metabolic process TAS--
    GO:0006771riboflavin metabolic process TAS--
    GO:0006777Mo-molybdopterin cofactor biosynthetic process IEA--

    FLAD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FLAD1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FLAD1 (FAD1)

    6 HMDB Compounds for FLAD1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    Flavin MononucleotideFMN (see all 19)146-17-8--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    4 Novoseek inferred chemical compound relationships for FLAD1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    riboflavin 82 10 20060505 (1), 19569646 (1), 16081269 (1), 8881717 (1) (see all 8)
    flavin-adenine dinucleotide 79.7 2 12517446 (1), 19240958 (1)
    flavin mononucleotide 76.5 3 19569646 (1)
    flavin 73.6 2 8881717 (1), 9644264 (1)

    Search CenterWatch for drugs/clinical trials and news about FLAD1 / FAD1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FLAD1 gene (4 alternative transcripts): 
    NM_001184891.1  NM_001184892.1  NM_025207.4  NM_201398.2  

    Unigene Cluster for FLAD1:

    Flavin adenine dinucleotide synthetase 1
    Hs.118666  [show with all ESTs]
    Unigene Representative Sequence: NM_025207
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000492620 ENST00000368433(uc001fgd.2) ENST00000315144(uc001fge.2)
    ENST00000368432(uc001fgg.2) ENST00000368431(uc001fgc.3) ENST00000292180(uc001fgf.2)
    ENST00000487371 ENST00000295530(uc001fgh.1) ENST00000368428 ENST00000489992
    ENST00000477609 ENST00000481758 ENST00000405236
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    Additional mRNA sequence: 

    AF218022.1 AF481877.1 AF520568.1 AK025979.1 AK308243.1 AY545550.1 BC011378.1 BC014012.2 
    BC020253.1 BC021096.1 BC032323.1 DQ458779.1 U79241.1 

    24 DOTS entries:

    DT.100829891  DT.444810  DT.100029164  DT.95253193  DT.100828220  DT.121413889  DT.100699547  DT.100828208 
    DT.121413714  DT.100828210  DT.100029162  DT.87011710  DT.100828216  DT.92436438  DT.121413938  DT.92436440 
    DT.86994148  DT.92436441  DT.121413836  DT.121413907  DT.92436436  DT.121413964  DT.87015794  DT.95253197 

    24/300 AceView cDNA sequences (see all 300):

    BG285944 AF520568 AF218022 BQ939808 CD517031 BC020253 BC032323 AX746501 
    AF481877 CR617327 BM453133 CR622894 BM925036 CB242198 BU175895 CR591714 
    BE791982 AA480112 NM_025207 BI754823 BE259545 AK090542 BU181903 BC021096 

    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for FLAD1 (see all 17)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^
    SP1:                          -           -     -     -     -                                                                       -                 -     -   
    SP2:                          -           -     -     -     -                                                                       -                 -     -   
    SP3:                                      -     -     -     -                                                                       -                 -     -   
    SP4:                                                                                                  -     -     -                 -                 -     -   
    SP5:                                      -     -     -     -                                                                                                   

    ExUns: 12 ^ 13a · 13b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for FLAD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FLAD1 expression in normal human tissues (normalized intensities)      FLAD1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTCCCACC
    FLAD1 Expression
    About this image


    FLAD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See FLAD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FLAD1

    SOURCE GeneReport for Unigene cluster: Hs.118666
        SABiosciences Custom PCR Arrays for FLAD1
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FLAD1 gene from 8/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Flad11 , 5 RFad1, flavin adenine dinucleotide synthetase, homolog more1, 5 86.23(n)1
    89.98(a)1
      3 (39.10 cM)5
    3199451  NM_177041.31  NP_796015.21 
     894010045 
    chicken
    (Gallus gallus)
    Aves LOC1008578981 FAD synthase-like 64.17(n)
    62.96(a)
      100857898  XM_003642661.1  XP_003642709.1 
    lizard
    (Anolis carolinensis)
    Reptilia FLAD16
    Uncharacterized protein
    61(a)
    1 ↔ 1
    GL344514.1(24138-30430)
    African clawed frog
    (Xenopus laevis)
    Amphibia CF548370.12   -- 75.79(n)    CF548370.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.272122 Transcribed sequence with weak similarity to protein more 70.38(n)    57055166 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG168481 CG16848 49.84(n)
    44.81(a)
      34759  NM_135809.1  NP_609653.1 
    worm
    (Caenorhabditis elegans)
    Secernentea flad-11 Protein FLAD-1 46.82(n)
    40.25(a)
      3565030  NM_001027115.1  NP_001022286.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FAD1(YDL045C)4
    FAD11
    Flavin adenine dinucleotide (FAD) synthetase, performs more4
    Fad1p1
    44.94(n)1
    36.32(a)1
      4(373608-372688)4
    8515161, 4  NP_010239.11, 4 


    ENSEMBL Gene Tree for FLAD1 (if available)
    TreeFam Gene Tree for FLAD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/245 SNPs in FLAD1 are shown (see all 245)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1509629581,2
    --154953842(+) GGGGCA/GCCCCT 4 -- us2k10--------
    rs2011865181,2
    C--154953983(-) CCCCTC/TCCTTT 4 -- us2k10--------
    rs1911564831,2
    --154954057(+) TTGTGG/TTTGTG 4 -- us2k10--------
    rs1161148601,2
    F--154954107(+) AAAATG/AAGCAT 4 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1408104991,2
    --154954141(+) TTTTTC/GTTTTT 4 -- us2k10--------
    rs1830511501,2
    --154954466(+) CAATCC/TTCCCT 4 -- us2k10--------
    rs783698181,2
    F--154954564(+) AATTCG/AGCCCG 4 -- us2k11Minor allele frequency- A:0.07WA 118
    rs1874434891,2
    --154954568(+) CGGCCC/TGGCGC 4 -- us2k10--------
    rs618118941,2
    --154954608(+) TGGGAA/GGCCGA 4 -- us2k10--------
    rs1845802241,2
    --154954664(+) CACAGC/TGAAAC 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for FLAD1 (154955770 - 154965587 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FLAD1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509502CNV Insertion20534489
    nsv872454CNV Loss21882294
    nsv872453CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610595    OMIM disorders: --

    12 diseases for FLAD1:    About MalaCards
    associative agnosia    cholinergic urticaria    localized osteosarcoma    phimosis
    hydranencephaly    polyhydramnios    agnosia    urticaria
    osteosarcoma    nasopharyngitis    amyotrophic lateral sclerosis    lateral sclerosis

    4 diseases from the University of Copenhagen DISEASES database for FLAD1:
    Associative agnosia     Phimosis     Cholinergic urticaria     Localized osteosarcoma

    FLAD1 for disorders           About GeneDecksing


    Export disorders for FLAD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FLAD1 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with FLAD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Over-expression in Escherichia coli and characterization of two recombinant isoforms of human FAD synthetase. (PubMed id 16643857)1, 2, 9 Brizio C.... Barile M. (2006)
    2. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 2 Yu W.... Gibbs R.A. (1997)
    3. Specific electron transport chain abnormalities in amyotrophic lateral sclerosis. (PubMed id 19240958)1, 9 Lin J....Sadiq S.A. (2009)
    4. Over-expression in Escherichia coli, purification and characterization of isoform 2 of human FAD synthetase. (PubMed id 17049878)2, 9 Galluccio M.... Barile M. (2007)
    5. Identification of 23 new prostate cancer susceptibilit y loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    10. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80308 HGNC: 24671 AceView: PP591 Ensembl:ENSG00000160688 euGenes: HUgn80308
    ECgene: FLAD1 Kegg: 80308 H-InvDB: FLAD1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FLAD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FLAD1 gene:
    Search GeneIP for patents involving FLAD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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