V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

FOXO3 Gene

protein-coding GIFtS: 59

GC06P108988

forkhead box O3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: FKHRL1, FOXO3A)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AF6q21 ^¹, ²
DKFZp781A0677 ^²
FKHRL1 ^², ³, ⁵
FKHRL1P2 ^²
FOXO2 ^¹, ²
FOXO3A ^², ³, ⁵
MGC12739 ^²
MGC31925 ^²
OTTHUMP00000016944 ^²

Descriptions
AF6q21 protein ^³
Forkhead in rhabdomyosarcoma-like 1 ^³
forkhead box O3 ^²
forkhead box O3A ^²
forkhead homolog (rhabdomyosarcoma) like 1 ^²
forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1 ^²

External Ids
HGNC: 3821¹
Entrez Gene: 2309²
UniProtKB: O43524³
Ensembl: ENSG00000118689⁷

Search outside databases for aliases for FOXO3 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FOXO3:

This gene belongs to the forkhead family of transcription factors which are characterized by a

distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression

of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with

secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have

been observed. [provided by RefSeq]

UniProtKB/Swiss-Prot: FOXO3_HUMAN, O43524

Function: Transcriptional activator which triggers apoptosis in the absence of survival factors,

including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence

5'-[AG]TAAA[TC]A-3'

Gene Wiki entry for FOXO3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21 Ensembl cytogenetic band: 6q21 HGNC cytogenetic band: 6q21

FOXO3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P108988: (about GC identifiers)

Start:	108,987,719 bp from pter
End:	109,112,664 bp from pter
Size:	124,946 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000006.10 NT_025741.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: FOXO3_HUMAN, O43524 (See protein sequence)

Recommended Name: Forkhead box protein O3

Size: 673 amino acids; 71277 Da

Subunit: Interacts with YWHAB/14-3-3-beta and YWHAZ/14-3-3-zeta, which are required for cytosolic

sequestration. Upon oxidative stress, interacts with STK4, which disrupts interaction with

YWHAB/14-3-3-beta and leads to nuclear translocation

Subcellular location: Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus upon oxidative

stress and in the absence of survival factors

PDB structure from and Proteopedia :

2K86 (3D)

2UZK (3D)

Secondary accessions: O15171 Q5T2I7 Q9BZ04

Post-translational modifications:

In the presence of survival factors such as IGF-1, phosphorylated on Thr-32 and Ser-253 by

AKT1/PKB. This phosphorylated form then interacts with 14-3-3 proteins and is retained in the

cytoplasm. Survival factor withdrawal induces dephosphorylation and promotes translocation to the

nucleus where the dephosphorylated protein induces transcription of target genes and triggers

apoptosis. Although AKT1/PKB doesn't appear to phosphorylate Ser-315 directly, it may activate

other kinases that trigger phosphorylation at this residue. Phosphorylated by STK4 on Ser-209 upon

oxidative stress, which leads to dissociation from YWHAB/14-3-3-beta and nuclear translocation¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001446.1 NP_963853.1

ENSEMBL proteins:

ENSP00000339527 ENSP00000385824

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (FOXO3A, FOXO1 + FOXO3 + FOXO4)
	Human Recombinant Proteins from Abnova (FOXO3A)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	10102273 16751106
GO:0005737	cytoplasm	IDA	10102273 16751106

About this table

Antibodies for FOXO3:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of FOXO3
	Sigma-Aldrich Antibody Arrays and Antibodies for FOXO3
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for FOXO3 (Foxo3a)
	Antibodies from Abcam (FOXO3A, FOXO1 + FOXO3 + FOXO4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (FOXO3A)
	Novus Biologicals Antibodies for FOXO3

Assays for FOXO3:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of FOXO3
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O43524

ProtoNet protein and cluster: O43524

UniProtKB/Swiss-Prot: FOXO3_HUMAN, O43524

Similarity: Contains 1 fork-head DNA-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FOXO3)
		Millipore RNAi Products for the Analysis of FOXO3 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (FOXO3A)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001455

Applied Biosystems Silencer® siRNAs for FOXO3

Sigma-Aldrich siRNA for FOXO3

Sigma-Aldrich shRNA Panels and shRNA for FOXO3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FOXO3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001455
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001455
untagged cDNA clones in CMV expression vector (see all 3): NM_001455

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_201559

UniProtKB/Swiss-Prot: FOXO3_HUMAN, O43524

Function: Transcriptional activator which triggers apoptosis in the absence of survival factors,

including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence

5'-[AG]TAAA[TC]A-3'

13 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Foxo3):

	cellular	digestive/alimentary	endocrine/exocrine gland	hematopoietic system
homeostasis/metabolism	immune system	life span-post-weaning/aging	renal/urinary system	reproductive system
respiratory system	skin/coat/nails	tumorigenesis

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IDA	14734530
GO:0005515	protein binding	IPI	16809346 18781224
GO:0016563	transcription activator activity	IDA	10102273
GO:0019901	protein kinase binding	IPI	16751106
GO:0043565	sequence-specific DNA binding	IDA	10102273

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/8 Sigma-Aldrich "Your Favorite Gene" Pathways for FOXO3 (Your Favorite Gene powered by Ingenuity) (see all 8 )

VEGF Signaling
Non-Small Cell Lung Cancer Signaling
PTEN Signaling
Insulin Receptor Signaling
IGF-1 Signaling

GeneDecks FOXO3 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for FOXO3

5/89 Interacting proteins for FOXO3 (ENSP00000339527³ O43524^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 89 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FOXM1	Q08050¹	STRING (score=.76) EBI-1644164, EBI-866480
SIRT3	Q9NTG7¹	STRING (score=.955) EBI-1644164, EBI-724621
YWHAZ	P63104²	STRING (score=.96) MINT-14323
AKT1	ENSP00000270202³	STRING (score=.999)
BCL2L11	ENSP00000350311³	STRING (score=.999)

About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006915	apoptosis	IDA	10102273
GO:0045648	positive regulation of erythrocyte differentiation	IDA	14734530
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA	10102273

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FOXO3
9 Novoseek chemical compound relationships for FOXO3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
phosphatidylinositol	69.41	10	14701673 (1), 15207915 (1), 16687394 (1), 18388194 (1) (see all 8)
wortmannin	45.84	1	18385518 (1)
phosphoinositide	44.24	4	19302476 (1), 12150827 (1), 12504093 (1), 15322085 (1)
glycogen	39.35	6	18476967 (1), 11237865 (1), 17522055 (1), 12139625 (1) (see all 5)
tyrosine	32.77	6	17900262 (2), 19285077 (1), 12456669 (1), 12506011 (1)
threonine	18.34	1	12359217 (1)
oxygen	0.00	3	15741276 (1), 15674333 (1), 14713953 (1)
oligonucleotide	0.00	1	16687394 (1)
nitric oxide	0.00	9	12599246 (4), 17044646 (2), 16687394 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FOXO3)
		Millipore RNAi Products for the Analysis of FOXO3 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (FOXO3A)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001455

Sigma-Aldrich siRNA for FOXO3

Sigma-Aldrich shRNA Panels and shRNA for FOXO3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001455 NM_201559

REFSEQ mRNAs for FOXO3 gene (2 alternative transcripts):

NM_001455.3 NM_201559.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001455 NM_201559

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001455
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001455
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001455

Additional cDNA sequence:

AB072905.1 AF032886.1 AJ001589.1 AK024103.1 AK092357.1 AK122861.1 AK301304.1 AK303933.1

AK311587.1 BC020227.1 BC021224.2 BC045800.1 BC068552.1 CR623727.1 CR749261.1

19 DOTS entries:

DT.100649722 DT.95294944 DT.100755530 DT.216108 DT.121004366 DT.100649556 DT.101981892 DT.97771444

DT.100823907 DT.100755532 DT.91746714 DT.100726911 DT.95200828 DT.95354316 DT.121313784 DT.91901643

DT.95162771 DT.100702119 DT.99940058

24/142 AceView cDNA sequences (see all 142 ):

AI031844 AF032886 BX282546 BE502772 BC020227 NM_001455 BF222626 CF541001

AI075785 AI919238 BC021224 BQ214507 AA603521 BQ636125 AI421125 AA465236

AI554317 BM718517 N29118 BX503867 BG057950 NM_201559 CA389775 AW001951

Unigene Cluster for FOXO3:

Forkhead box O3

Hs.220950 [show with all ESTs]

Unigene Representative Sequence: NM_001455

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000343882 ENST00000406360

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FOXO3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FOXO3

¹ / ²

19 probe-sets matching FOXO3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
49651_at²	U95-C	1	1.00	1.00	0.66	1.17	--	--	--	--	--
47893_s_at²	U95-B	1	1.00	1.00	0.64	0.97	--	--	--	--	--
34740_at²	U95-A	1	1.00	1.00	0.64	0.78	--	--	--	--	--
49469_at²	U95-B	2	0.94	0.94	0.82	1.48	--	--	--	--	--
57934_s_at*²	U95-B	1	--	--	0.62	0.60	--	--	--	--	--
224891_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
204132_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
224889_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
204131_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
217399_s_at²	U133-A	2	1.00	0.91	--	--	--	--	--	--	--
210655_s_at²	U133-A	2	1.00	0.50	--	--	--	--	--	--	--
231548_at*²	U133-B	NULL	0.00	0.00	--	--	--	--	--	--	--
224891_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204132_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
224889_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204131_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
217399_s_at²	U133Plus2	2	1.00	0.91	--	--	--	--	--	--	--
210655_s_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--
231548_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

GeneDecks FOXO3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAAATAAAGC

SOURCE GeneReport for Unigene cluster: Hs.220950
UniProtKB/Swiss-Prot: FOXO3_HUMAN, O43524
Tissue specificity: Ubiquitous

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FOXO3 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
cow (Bos taurus)	FOXO3¹	--	forkhead box O3	91.91(n) 96.58(a)	535530 XM_615634.3 XP_615634.2
rat (Rattus norvegicus)	Foxo3¹	--	forkhead box O3	89.98(n) 94.64(a)	294515 XM_215421.4 XP_215421.2
mouse (Mus musculus)	Foxo3^{1, 5}	10 (30.00 cM)⁵	forkhead box O3^{1, 5}	90.38(n)¹ 94.79(a)¹	56484¹ NM_019740.2¹ NP_062714.1¹ AF114259⁵ AI466816⁵ (see all 18)
chicken (Gallus gallus)	FOXO3¹	--	forkhead box O3	78.65(n) 86.74(a)	421769 XM_001234495.1 XP_001234496.1
zebrafish (Danio rerio)	AF114262.1²	--	--	77.12(n)	30296 AF114262.1

About this table Species with no ortholog for FOXO3

ENSEMBL Gene Tree for FOXO3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FOXO3 gene

FOXO6² FOXO4² FOXO1² FOXO3B²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/478 NCBI SNPs in FOXO3 are shown (see all 478 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 164)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs4946936^1,2	A,C,F,H	109110014(+)	`CAGTTC/TTACAG`	2	--	ut3¹		11		EU EA WA NA	974
--	rs4945816^1,2	A,C,F	109108735(+)	`ATGTGT/CGAAGA`	2	--	ut3¹		3		NA	142
--	rs11969027^1,2	A,C	108985744(+)	`GCCTAA/GCTGTC`	1	--	ng5¹		0	--	--	--	--
	rs9486915^1,2	F,H	109112994(+)	`CCTCAC/TTGAGC`	2	--	ng3¹		4		EU EA WA	420
--	rs13217182^1,2	F,H	109110440(+)	`CCTGTG/CTAGGG`	2	--	ut3¹		1		WA	120
--	rs1044959^1,2	F	109108424(+)	`TTTCCG/AGTTCT`	2	--	ut3¹ ese³		1		MN	184
--	rs13217547^1,2	A	109110550(+)	`CTTATA/GTTGAG`	2	--	ut3¹		0	--	--	--	--
	rs11752388^1,2	H	108986281(+)	`CTCGAT/ATGTTT`	1	--	ng5¹ tfbs³		4		EU EA WA	412
	rs2153960^1,2	A,C,F,H,O	109094877(-)	`CAAGGC/TTCAAG`	2	--	int¹		8		EU EA WA NA	632
	rs2802290^1,2	A,C,F,H,O	109012373(+)	`TTTCAA/GGGAGG`	2	--	int¹		12		EA NA EU WA	996

About this table

HapMap Linkage Disequilibrium images for FOXO3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602681

UniProtKB/Swiss-Prot: FOXO3_HUMAN, O43524

A chromosomal aberration involving FOXO3 is found in secondary acute leukemias.

Translocation t(6;11)(q21;q23) with MLL/HRX

10/12 Novoseek disease relationships for FOXO3 gene (see all 12 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
rhabdomyosarcoma	38.92	1	12196101 (1)
breast cancer	33.90	26	18312651 (4), 17575143 (4), 14527951 (3), 19276163 (2) (see all 11)
prostate cancer	31.39	11	12351634 (3), 17522055 (2), 15798096 (2), 17563745 (1) (see all 5)
leukemia	27.79	2	11278373 (1), 18055337 (1)
tumors	24.79	17	15551757 (3), 15084260 (2), 18312651 (2), 12351634 (2) (see all 10)
myeloid leukemia chronic	20.26	4	17900262 (1), 12456669 (1), 18644865 (1)
cancer	20.05	4	16861905 (1), 18239069 (1), 19299143 (1), 18158893 (1)
necrosis	7.54	3	17900262 (1), 18166693 (1), 15322085 (1)
neovascularization	0.41	1	16100571 (1)
neurodegenerative diseases	0.00	1	18045156 (1)

About this table

Human Genome Epidemiology Navigator: FOXO3 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/217 PubMed articles for FOXO3 gene (see all 217 ):

Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. (PubMed id 9479491)^{1, 2, 3, 4} Anderson M.J.... Arden K.C. (1998)
Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). (PubMed id 11154281)^{1, 3, 4} Brunet A.... Greenberg M.E. (2001)
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. (PubMed id 10102273)^{1, 3, 4} Brunet A.... Greenberg M.E. (1999)
Crystal structure of the human FOXO3a-DBD/DNA complex suggests the effects of post-translational modification. (PubMed id 17940099)^{3, 4} Tsai K.L....Hsiao C.D. (2007)
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. (PubMed id 16751106)^{3, 4} Lehtinen M.K.... Bonni A. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{3, 4} Mungall A.J.... Beck S. (2003)
AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily. (PubMed id 9345057)^{3, 4} Hillion J.... Bernard O.A. (1997)
Regulation of FOXO3a by brain-derived neurotrophic factor in differentiated human SH-SY5Y neuroblastoma cells. (PubMed id 15207915)^{1, 3} Zhu W....Li X. (2004)
Forkhead box transcription factor FOXO3a suppresses estrogen-dependent breast cancer cell proliferation and tumorigenesis. (PubMed id 18312651)^{1, 3} Zou Y....Hu M.C. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2309	HGNC: 3821	AceView: FOXO3A	Ensembl:ENSG00000118689	euGenes: HUgn2309
ECgene: FOXO3	H-InvDB: FOXO3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for FOXO3	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for FOXO3
(Available from WIS Yeda, Salk, Tufts)

About This Section

Licensable Technologies for FOXO3 gene:

Salk Institute:

Increasing Life Span by Modulation of the Smek Gene

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for FOXO3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FOXO3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FOXO3		Antibodies for FOXO3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for FOXO3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (FOXO3A)
	Antibodies (FOXO3A)
	Chimera RNAi (FOXO3A)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for FOXO3 (Foxo3a)

	Recombinant Proteins (FOXO3A, FOXO1 + FOXO3 + FOXO4)
	Antibodies (FOXO3A, FOXO1 + FOXO3 + FOXO4)

Search OriGene for FOXO3

Search Tocris compounds for FOXO3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for FOXO3

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
FOXO3 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

FOXO3 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for FOXO3

Summaries
for FOXO3

Genomic Location
for FOXO3

Proteins
for FOXO3

Protein Domains/
Families
for FOXO3

Gene Function
for FOXO3

Pathways & Interactions
for FOXO3

Drugs & Compounds
for FOXO3

Transcripts
for FOXO3

Expression
for FOXO3

Orthologs
for FOXO3

Paralogs
for FOXO3

SNPs/Variants
for FOXO3

Disorders & Mutations
for FOXO3

Medical News
for FOXO3

Publications
for FOXO3

Search for FOXO3

Genome Databases showing FOXO3

Other Databases showing FOXO3

Specialized Databases showing FOXO3

Licensable Technologies
for FOXO3

Services
for FOXO3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FOXO3 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor FOXO3

Summariesfor FOXO3

Genomic Locationfor FOXO3

Proteinsfor FOXO3

Protein Domains/Familiesfor FOXO3

Gene Functionfor FOXO3

Pathways & Interactionsfor FOXO3

Drugs & Compoundsfor FOXO3

Transcriptsfor FOXO3

Expression for FOXO3

Orthologsfor FOXO3

Paralogsfor FOXO3

SNPs/Variantsfor FOXO3

Disorders & Mutationsfor FOXO3

Medical Newsfor FOXO3

Publicationsfor FOXO3

Search for FOXO3

Genome Databases showing FOXO3

Other Databases showing FOXO3

Specialized Databases showing FOXO3

Licensable Technologiesfor FOXO3

Servicesfor FOXO3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FOXO3

Summaries
for FOXO3

Genomic Location
for FOXO3

Proteins
for FOXO3

Protein Domains/
Families
for FOXO3

Gene Function
for FOXO3

Pathways & Interactions
for FOXO3

Drugs & Compounds
for FOXO3

Transcripts
for FOXO3

Expression
for FOXO3

Orthologs
for FOXO3

Paralogs
for FOXO3

SNPs/Variants
for FOXO3

Disorders & Mutations
for FOXO3

Medical News
for FOXO3

Publications
for FOXO3

Licensable Technologies
for FOXO3

Services
for FOXO3