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FOXO1 Gene

protein-coding GIFtS: 56

GC13M040028

forkhead box O1
(Previous name: forkhead homolog in rhabdomyosarcoma )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: FKHR, FOXO1A)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FKH1 ^¹, ²
FKHR ^², ³
FOXO1A ^², ³
OTTHUMP00000018301 ^²

Descriptions
Forkhead box protein O1A ^³
Forkhead in rhabdomyosarcoma ^³
forkhead box O1 ^²
forkhead box O1A (rhabdomyosarcoma) ^²
forkhead homolog in rhabdomyosarcoma ^¹, ²
forkhead, Drosophila, homolog of, in rhabdomyosarcoma ^²

External Ids
HGNC: 3819¹
Entrez Gene: 2308²
UniProtKB: Q12778³
Ensembl: ENSG00000150907⁷

Search outside databases for aliases for FOXO1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FOXO1:

This gene belongs to the forkhead family of transcription factors which are characterized by a

distinct forkhead domain. The specific function of this gene has not yet been determined; however,

it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3

has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq]

UniProtKB/Swiss-Prot: FOXO1_HUMAN, Q12778

Function: Transcription factor

Gene Wiki entry for FOXO1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.1 Ensembl cytogenetic band: 13q14.11 HGNC cytogenetic band: 13q14.1

FOXO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13M040028: (about GC identifiers)

Start:	40,027,801 bp from pter
End:	40,138,734 bp from pter
Size:	110,934 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000013.9 NT_024524.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: FOXO1_HUMAN, Q12778 (See protein sequence)

Recommended Name: Forkhead box protein O1

Size: 655 amino acids; 69662 Da

Subunit: Interacts with LRPPRC (By similarity)

Subcellular location: Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and nucleus

PDB structures from and Proteopedia :

3CO6 (3D)

3CO7 (3D)

3COA (3D)

Secondary accessions: O43523 Q5VYC7 Q6NSK6

Post-translational modifications:

Phosphorylated by AKT1; insulin-induced (By similarity). IGF1 rapidly induces phosphorylation of

Ser-256, Thr-24, and Ser-319. Phosphorylation of Ser-256 decreases DNA-binding activity and

promotes the phosphorylation of Thr-24, and Ser-319, permitting phosphorylation of Ser-322 and

Ser-325, probably by CK1, leading to nuclear exclusion and loss of function. Phosphorylation of

Ser-329 is independent of IGF1 and leads to reduced function. Phosphorylated upon DNA damage,

probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002006.2

ENSEMBL proteins:

ENSP00000368880

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant FOXO1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (FOXO1A, FOXO1 + FOXO3 + FOXO4)
	Human Recombinant Proteins from Abnova (FOXO1A)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	11311120 12228231
GO:0005737	cytoplasm	IDA	11311120 12228231

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Antibodies for FOXO1:

	Invitrogen Antibodies for FOXO1
	Millipore Mono- and Polyclonal Antibodies for the study of FOXO1
	Sigma-Aldrich Antibody Arrays and Antibodies for FOXO1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for FOXO1
	Antibodies from Abcam (FOXO1A, FOXO1 + FOXO3 + FOXO4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (FOXO1A)
	Novus Biologicals Antibodies for FOXO1

Assays for FOXO1:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of FOXO1
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q12778

ProtoNet protein and cluster: Q12778

UniProtKB/Swiss-Prot: FOXO1_HUMAN, Q12778

Similarity: Contains 1 fork-head DNA-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FOXO1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FOXO1A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002015

Applied Biosystems Silencer® siRNAs for FOXO1

Sigma-Aldrich siRNA for FOXO1

Sigma-Aldrich shRNA Panels and shRNA for FOXO1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002015
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002015
untagged cDNA clone in CMV expression vector: NM_002015

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002015

UniProtKB/Swiss-Prot: FOXO1_HUMAN, Q12778

Function: Transcription factor

14 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Foxo1):

	craniofacial	digestive/alimentary	embryogenesis	endocrine/exocrine gland
growth/size	hematopoietic system	homeostasis/metabolism	immune system	lethality-postnatal
lethality-prenatal/perinatal	life span-post-weaning/aging	normal	tumorigenesis

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IEA	--
GO:0005515	protein binding	IPI	11353774 17202144 18408765
GO:0016563	transcription activator activity	IDA	7862145 10871843 12228231
GO:0043565	sequence-specific DNA binding	IDA	12228231

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/14 Sigma-Aldrich "Your Favorite Gene" Pathways for FOXO1 (Your Favorite Gene powered by Ingenuity) (see all 14 )

FXR/RXR Activation
VEGF Signaling
IGF-1 Signaling
Molecular Mechanisms of Cancer
PI3K/AKT Signaling

GeneDecks FOXO1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for FOXO1

5/146 Interacting proteins for FOXO1 (ENSP00000368880³ Q12778¹) via UniProtKB, MINT, and/or STRING (see all 146 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AR	P10275¹	STRING (score=.988) EBI-1108782, EBI-608057
CDC2	P06493¹	STRING (score=.977) EBI-1108782, EBI-444308
ESR1	P03372¹	STRING (score=.903) EBI-1108782, EBI-78473
AKT1	ENSP00000270202³	STRING (score=.999)
SIRT1	ENSP00000212015³	STRING (score=.999)

About this table

5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001568	blood vessel development	IEA	--
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006916	anti-apoptosis	IDA	10871843
GO:0008286	insulin receptor signaling pathway	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FOXO1
10/11 Novoseek chemical compound relationships for FOXO1 gene (see all 11 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
phosphatidylinositol	66.00	13	11672436 (1), 15778376 (1), 17202144 (1), 12606579 (1) (see all 8)
phosphoenolpyruvate	53.17	1	10913147 (1)
glycogen	49.45	9	15494423 (1), 15574783 (1), 12702569 (1), 16973122 (1) (see all 9)
phosphoinositide	47.51	2	12150827 (1), 17986386 (1)
threonine	36.48	6	12359217 (1), 13679577 (1), 11733864 (1), 18211894 (1)
manganese superoxide	19.47	1	17408630 (1)
glucose	18.23	12	19141580 (3), 10960473 (2), 13679577 (1), 16670091 (1) (see all 6)
progesterone	0.89	9	15987820 (4), 18096667 (1), 17556536 (1)
estradiol	0.00	1	16614392 (1)
tyrosine	0.00	1	11825565 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FOXO1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FOXO1A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002015

Sigma-Aldrich siRNA for FOXO1

Sigma-Aldrich shRNA Panels and shRNA for FOXO1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002015

REFSEQ mRNAs for FOXO1 gene:

NM_002015.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002015

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002015
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002015
                                 untagged cDNA clone in CMV expression vector: NM_002015

Additional cDNA sequence:

AF032885.1 AK310511.1 BC021981.2 BC070065.1 BT007455.1 BX648278.1 U02310.1 U36922.1

8 DOTS entries:

DT.317826 DT.92454302 DT.40105832 DT.120780767 DT.95151680 DT.91904470 DT.101958152 DT.92454306

24/263 AceView cDNA sequences (see all 263 ):

BP345665 CA447146 AI889401 H82288 BQ879203 CF529560 BC021981 AW182316

NM_002015 AF032885 AW072902 CB069714 AI188507 AW050917 T85080 BQ718121

T85079 AA134749 BC070065 AA130464 BF733006 AI813640 CA309741 CA503017

Unigene Cluster for FOXO1:

Forkhead box O1

Hs.370666 [show with all ESTs]

Unigene Representative Sequence: NM_002015

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for FOXO1

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6
SP1:			-		-		-
SP2:					-
SP3:					-		-
SP4:							-

About this scheme

ECgene alternative splicing isoforms for FOXO1

1 Ensembl transcript including schematic representation:

ENST00000379561

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FOXO1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FOXO1

¹ / ²

5 probe-sets matching FOXO1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40570_at²	U95-A	1	1.00	1.00	1.00	1.00	--	--	--	--	--
202724_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
202723_s_at²	U133-A	2	1.00	0.95	--	--	--	--	--	--	--
202724_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202723_s_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCTCCTGCAT

SOURCE GeneReport for Unigene cluster: Hs.370666
UniProtKB/Swiss-Prot: FOXO1_HUMAN, Q12778
Tissue specificity: Ubiquitous

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FOXO1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	FOXO1¹	--	forkhead box O1	91.36(n) 93.91(a)	477295 XM_534487.2 XP_534487.2
chimpanzee (Pan troglodytes)	FOXO1¹	--	forkhead box O1	99.75(n) 100(a)	467352 XM_522749.2 XP_522749.2
rat (Rattus norvegicus)	Foxo1¹	--	forkhead box O1	88.91(n) 92.91(a)	84482 XM_342244.3 XP_342245.2
mouse (Mus musculus)	Foxo1^{1, 5}	3 (22.50 cM)⁵	forkhead box O1^{1, 5}	89.37(n)¹ 93.53(a)¹	56458¹ NM_019739.2¹ NP_062713.2¹ AA254887⁵ AF114258⁵ (see all 26)
chicken (Gallus gallus)	FOXO1A¹	--	forkhead box O1A	78.49(n) 79.06(a)	374231 NM_204328.1 NP_989659.1

About this table Species with no ortholog for FOXO1

ENSEMBL Gene Tree for FOXO1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FOXO1 gene

FOXO6² FOXO4² FOXO3² FOXO3B²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/582 NCBI SNPs in FOXO1 are shown (see all 582 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 165)

AB	SNP ID	Valid	Chr 13 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3751437^1,2	A,C,H	40031080(-)	`TTTCTC/G/TGGTTA`	1	--	ut3¹ ese³		4		EU EA WA	416
	rs17592236^1,2	C,F,H	40029932(+)	`AAGGAC/TCATTG`	1	--	ut3¹ ese³		7		NA EU EA WA	560
	rs9577065^1,2	A,F,H	40027732(+)	`ACTATA/GGTTTG`	1	--	ng5¹		4		EU EA WA	412
	rs9577066^1,2	A,F,H	40030149(+)	`CCCAAC/ACAGGG`	1	--	ut3¹ ese³		4		EU EA WA	418
	rs9532558^1,2	F,H	40031015(+)	`AAATGT/CCTTTG`	1	--	ut3¹		4		EU EA WA	414
	rs1885269^1,2	C,H	40029067(+)	`TACCCG/AGGAGG`	1	--	ut3¹ ese³		7		NA EU EA WA	558
--	rs3841231^1,2	C	40030554(+)	`TTTTT-/TCCAAA`	1	--	ut3¹ trp³		0	--	--	--	--
	rs12184581^1,2	H	40139086(+)	`AGGCGG/CCGGCG`	1	--	ng3¹		4		EU EA WA	412
--	rs12429037^1,2	A	40137858(+)	`GCGTAA/GGACAG`	1	S/S	syn¹ ese³		0	--	--	--	--
	rs1923249^1,2	A,C,F,H,O	40041881(+)	`AGATAA/CAGCAG`	1	--	int¹		12		NS EU EA WA NA	652

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HapMap Linkage Disequilibrium images for FOXO1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 136533

UniProtKB/Swiss-Prot: FOXO1_HUMAN, Q12778

Chromosomal aberrations involving FOXO1 are a cause of rhabdomyosarcoma 2 (RMS2)

[MIM:268220]; also known as alveolar rhabdomyosarcoma. Translocation (2;13)(q35;q14) with PAX3;

translocation t(1;13)(p36;q14) with PAX7. The resulting protein is a transcriptional activator

10/18 Novoseek disease relationships for FOXO1 gene (see all 18 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
rhabdomyosarcoma alveolar	92.53	19	11171995 (2), 7630639 (1), 8875708 (1), 8889501 (1) (see all 17)
muscle cancer	85.53	1	16140913 (1)
rhabdomyosarcoma	75.12	13	11672436 (1), 12196101 (1), 12456685 (1), 12606579 (1) (see all 9)
sarcoma	29.79	3	18303411 (1)
tumors	29.53	16	12351634 (2), 8634710 (1), 15688409 (1), 19047133 (1) (see all 14)
insulin resistance	24.15	6	10912522 (1), 15910615 (1), 16041833 (1), 17077083 (1) (see all 6)
fatty liver	23.95	1	17408630 (1)
childhood cancer	22.56	2	10700864 (1), 15184910 (1)
hyperinsulinemia	20.15	3	17408630 (1), 16670091 (1), 17317207 (1)
insulin sensitivity	19.21	4	16670091 (1), 16041833 (1), 17317207 (1)

About this table

Human Genome Epidemiology Navigator: FOXO1 (9 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/281 PubMed articles for FOXO1 gene (see all 281 ):

Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma. (PubMed id 8275086)^{2, 3, 4} Galili N.... Barr F.G. (1993)
Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding. (PubMed id 12228231)^{1, 3, 4} Zhang X.... Unterman T.G. (2002)
Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. (PubMed id 9479491)^{1, 3, 4} Anderson M.J.... Arden K.C. (1998)
Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion. (PubMed id 11980723)^{1, 3, 4} Rena G....Cohen P. (2002)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)^{3, 4} Dunham A.... Ross M.T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site. (PubMed id 11311120)^{3, 4} Woods Y.L.... Cohen P. (2001)
Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. (PubMed id 10358075)^{3, 4} Rena G.... Cohen P. (1999)
Hepatocyte nuclear factor-4 is a novel downstream target of insulin via FKHR as a signal-regulated transcriptional inhibitor. (PubMed id 12519792)^{1, 3} Hirota K....Fukamizu A. (2003)
Aberrant over-expression of a forkhead family member, FOXO1A, in a brain tumor cell line. (PubMed id 17442120)^{1, 3} Dallas P.B....Kees U.R. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2308	HGNC: 3819	AceView: FOXO1A	Ensembl:ENSG00000150907	euGenes: HUgn2308
ECgene: FOXO1	H-InvDB: FOXO1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for FOXO1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for FOXO1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for FOXO1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FOXO1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FOXO1		Antibodies for FOXO1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for FOXO1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (FOXO1A)
	Antibodies (FOXO1A)
	Chimera RNAi (FOXO1A)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for FOXO1

	Recombinant Proteins (FOXO1A, FOXO1 + FOXO3 + FOXO4)
	Antibodies (FOXO1A, FOXO1 + FOXO3 + FOXO4)

Search OriGene for FOXO1

Search Tocris compounds for FOXO1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for FOXO1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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FOXO1 Gene at Home site.
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FOXO1 Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for FOXO1

Summaries
for FOXO1

Genomic Location
for FOXO1

Proteins
for FOXO1

Protein Domains/
Families
for FOXO1

Gene Function
for FOXO1

Pathways & Interactions
for FOXO1

Drugs & Compounds
for FOXO1

Transcripts
for FOXO1

Expression
for FOXO1

Orthologs
for FOXO1

Paralogs
for FOXO1

SNPs/Variants
for FOXO1

Disorders & Mutations
for FOXO1

Medical News
for FOXO1

Publications
for FOXO1

Search for FOXO1

Genome Databases showing FOXO1

Other Databases showing FOXO1

Specialized Databases showing FOXO1

Licensable Technologies
for FOXO1

Services
for FOXO1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FOXO1 Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor FOXO1

Summariesfor FOXO1

Genomic Locationfor FOXO1

Proteinsfor FOXO1

Protein Domains/Familiesfor FOXO1

Gene Functionfor FOXO1

Pathways & Interactionsfor FOXO1

Drugs & Compoundsfor FOXO1

Transcriptsfor FOXO1

Expression for FOXO1

Orthologsfor FOXO1

Paralogsfor FOXO1

SNPs/Variantsfor FOXO1

Disorders & Mutationsfor FOXO1

Medical Newsfor FOXO1

Publicationsfor FOXO1

Search for FOXO1

Genome Databases showing FOXO1

Other Databases showing FOXO1

Specialized Databases showing FOXO1

Licensable Technologiesfor FOXO1

Servicesfor FOXO1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FOXO1

Summaries
for FOXO1

Genomic Location
for FOXO1

Proteins
for FOXO1

Protein Domains/
Families
for FOXO1

Gene Function
for FOXO1

Pathways & Interactions
for FOXO1

Drugs & Compounds
for FOXO1

Transcripts
for FOXO1

Expression
for FOXO1

Orthologs
for FOXO1

Paralogs
for FOXO1

SNPs/Variants
for FOXO1

Disorders & Mutations
for FOXO1

Medical News
for FOXO1

Publications
for FOXO1

Licensable Technologies
for FOXO1

Services
for FOXO1