FOXG1 Gene
protein-coding GIFtS: 49
GC14P028306
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forkhead box G1 (Previous names: forkhead box G1B, forkhead box G1C, forkhead box G1A ) Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbols: FKHL2, FOXG1B, FKHL4, FKH2, FKHL1, FOXG1C, FKHL3, FOXG1A)
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Aliases & Descriptions for FOXG1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
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| Aliases |
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| BF1 1, 2, 3 | | BF2 2, 3 | | FHKL3 2 | | FKH2 2, 3 | | FKHL1 2, 3 | | FKHL2 2, 3 | | FKHL3 2, 3 | | FKHL4 2, 3 | | FOXG1A 2, 3 | | FOXG1B 2, 3 | | FOXG1C 2, 3 | | HBF-1 2 | | HBF-2 2 | | HBF-3 1, 2 | | HBF-G2 2 | | HBF2 2 | | HFK1 1, 2, 3 | | HFK2 1, 2, 3 | | HFK3 1, 2, 3 | | KHL2 2 | | OTTHUMP00000178764 2 | | QIN 1, 2 | | hBF-2 3 |
| | | Descriptions |
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| Brain factor 1 3 | | Brain factor 2 2, 3 | | Forkhead box protein G1A 3 | | Forkhead box protein G1B 3 | | Forkhead box protein G1C 3 | | Forkhead-related protein FKHL1 3 | | Forkhead-related protein FKHL2 3 | | Forkhead-related protein FKHL3 3 | | Transcription factor BF-1 3 | | Transcription factor BF-2 3 | | forkhead box G1 2 | | forkhead box G1A 1, 2 | | forkhead box G1B 1, 2 | | forkhead box G1C 1, 2 | | forkhead, drosophila, homolog-like 2 2 | | forkhead-like 1 2 | | forkhead-like 2 2 | | forkhead-like 3 2 | | forkhead-like 4 2 | | oncogene QIN 2 |
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| | Search outside databases for aliases for FOXG1 gene |
Summaries for FOXG1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for FOXG1: This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of the brain and telencephalon. [provided by RefSeq] UniProtKB/Swiss-Prot: FOXG1_HUMAN, P55316Function: Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon |
Genomic Location for FOXG1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q13 Ensembl cytogenetic band: 14q12 HGNC cytogenetic band: 14q11-q13FOXG1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P028306:
(about GC identifiers)
Start:
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28,304,801 bp from pter |
End:
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28,309,230 bp from pter |
Size:
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4,430 bases |
Orientation:
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plus strand |
RefSeq DNA sequence:- NC_000014.7 NT_026437.11
| Proteins for FOXG1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: FOXG1_HUMAN, P55316 (See
protein sequence)Recommended Name: Forkhead box protein G1 Size: 489 amino acids; 52352 Da
Subunit: Interacts with KDM5B
Subcellular location: Nucleus
Caution: PubMed:7959731 claims that there are 3 different FOXG1 proteins, FOXG1A, FOXG1B, and FOXG1C. It was latter found that there is only one gene and the differences between these three may be sequencing errors since the protein is coded in a unique exon
Secondary accessions: A6NFY2 P55315 Q14488 Q86XT7Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005240.3
ENSEMBL proteins: ENSP00000371975 ENSP00000339004
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
NAS | -- | About this table
Antibodies for FOXG1: Assays for FOXG1: | Protein
Domains/ Families for FOXG1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P55316
ProtoNet protein and cluster: P55316 UniProtKB/Swiss-Prot: FOXG1_HUMAN, P55316Similarity: Contains 1 fork-head DNA-binding domain | Gene Function for FOXG1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005249
Applied Biosystems Silencer® siRNAs for FOXG1
Sigma-Aldrich siRNA for FOXG1  Sigma-Aldrich shRNA for FOXG1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005249                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005249                                  untagged cDNA clone in CMV expression vector: NM_005249 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005249
UniProtKB/Swiss-Prot: FOXG1_HUMAN, P55316Function: Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon15/21 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Foxg1) (see all 21
):
2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0003700 | transcription factor activity |
TAS | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- | About this table | Pathways & Interactions for FOXG1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for FOXG1 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for FOXG1 
5/29 Interacting proteins for FOXG1 (ENSP000003390043) via UniProtKB, MINT, and/or STRING (see all 29
)About this table
5/13 Gene Ontology (GO) biological process terms (links to tree view) (see all 13
): | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0002052 | positive regulation of neuroblast proliferation |
IEA | -- | | GO:0006350 | transcription |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
NAS | -- | | GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0007346 | regulation of mitotic cell cycle |
IEA | -- | About this table
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Drugs & Compounds for FOXG1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
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Browse Tocris compounds for FOXG1
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Transcripts for FOXG1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005249
Sigma-Aldrich siRNA for FOXG1  Sigma-Aldrich shRNA for FOXG1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005249 REFSEQ mRNAs for FOXG1 gene: NM_005249.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005249               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005249                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005249                                  untagged cDNA clone in CMV expression vector: NM_005249  Additional cDNA sequence: BC050072.1 CR602240.1 X74144.1 5 DOTS entries: DT.453370 DT.91952337 DT.95269931 DT.100748690 DT.95361559 9 AceView cDNA sequences:BI915241 BX408766 BX410672 BX404748 BI913371 BG910224 BX440747 BG912675 BX410673 Unigene Clusters for FOXG1: Forkhead box G1 Hs.695962 [show with all ESTs], Hs.708841 [show with all ESTs]Unigene Representative Sequences: NM_005249, BC050072
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000382535
ENST00000313071
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Expression for FOXG1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| FOXG1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for FOXG1
1 / 2 8 probe-sets matching FOXG1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene clusters: Hs.695962 Hs.708841 UniProtKB/Swiss-Prot: FOXG1_HUMAN, P55316Tissue specificity: Expression is restricted to the neurons of the developing telencephalon |
Orthologs for FOXG1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
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Orthologs for FOXG1 gene from 5/7 species (see all 7
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About this table Species with no ortholog for FOXG1
ENSEMBL Gene Tree for FOXG1 | Paralogs for FOXG1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for FOXG1 gene
- FOXF12 FOXQ12 FOXF22 FOXL22
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SNPs/Variants for FOXG1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
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HapMap Linkage Disequilibrium images for FOXG1 (up to first 250kb)
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Disorders & Mutations for FOXG1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
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OMIM: 164874
Human Gene Mutation Database: FOXG1
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Medical News for FOXG1(Possibly Related Articles in
Doctor's Guide)
About This Section
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Publications for FOXG1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/36 PubMed articles for FOXG1 gene (see all 36
):- Human brain factor 1, a new member of the fork head gene family. (PubMed id 7959731)1, 2, 3, 4 Murphy D.B.... Thies U. (1994)
- Comparative evolutionary analysis of the FoxG1 transcription factor from diverse vertebrates identifies conserved recognition sites for microRNA regulation. (PubMed id 17260156)2, 3, 4 Bredenkamp N....Illing N. (2007)
- Human PLU-1 has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9. (PubMed id 12657635)1, 3, 4 Tan K....Freemont P.S. (2003)
- The genes for human brain factor 1 and 2, members of the fork head gene family, are clustered on chromosome 14q. (PubMed id 7599184)1, 3, 4 Wiese S.... Thies U. (1995)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)3, 4 Heilig R.... Weissenbach J. (2003)
- The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription. (PubMed id 11238932)1, 3 Yao J....Stifani S. (2001)
- BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners. (PubMed id 10938097)1, 3 Dou C....Lai E. (2000)
- Haploinsufficiency of novel FOXG1B variants in a patient with severe mental retardation, brain malformations and microcephaly. (PubMed id 16133170)1, 3 Shoichet S.A....Kalscheuer V.M. (2005)
- FOXG1 is responsible for the congenital variant of Rett syndrome. (PubMed id 18571142)3 Ariani F....Renieri A. (2008)
- FOXG1 dysregulation is a frequent event in medulloblastoma. (PubMed id 17522785)3 Adesina A.M....Gumerlock M.K. (2007)
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Search for FOXG1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing FOXG1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing FOXG1
(According to HUGE)
About This Section
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Specialized Databases showing FOXG1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
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| About This Section
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| Services for FOXG1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
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 Products for FOXG1:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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