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FOXG1 Gene

protein-coding   GIFtS: 49

GC14P028306
forkhead box G1
(Previous names: forkhead box G1B, forkhead box G1C, forkhead box G1A )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: FKHL2, FOXG1B, FKHL4, FKH2, FKHL1, FOXG1C, FKHL3, FOXG1A)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
BF1 1, 2, 3
BF2 2, 3
FHKL3 2
FKH2 2, 3
FKHL1 2, 3
FKHL2 2, 3
FKHL3 2, 3
FKHL4 2, 3
FOXG1A 2, 3
FOXG1B 2, 3
FOXG1C 2, 3
HBF-1 2
HBF-2 2
HBF-3 1, 2
HBF-G2 2
HBF2 2
HFK1 1, 2, 3
HFK2 1, 2, 3
HFK3 1, 2, 3
KHL2 2
OTTHUMP00000178764 2
QIN 1, 2
hBF-2 3
Descriptions
Brain factor 1 3
Brain factor 2 2, 3
Forkhead box protein G1A 3
Forkhead box protein G1B 3
Forkhead box protein G1C 3
Forkhead-related protein FKHL1 3
Forkhead-related protein FKHL2 3
Forkhead-related protein FKHL3 3
Transcription factor BF-1 3
Transcription factor BF-2 3
forkhead box G1 2
forkhead box G1A 1, 2
forkhead box G1B 1, 2
forkhead box G1C 1, 2
forkhead, drosophila, homolog-like 2 2
forkhead-like 1 2
forkhead-like 2 2
forkhead-like 3 2
forkhead-like 4 2
oncogene QIN 2
External Ids
HGNC: 38111
Entrez Gene: 22902
UniProtKB: P553163
Ensembl: ENSG000001761657
Search outside databases for aliases for FOXG1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FOXG1:
This gene belongs to the forkhead family of transcription factors which is characterized by a
distinct forkhead domain. The specific function of this gene has not yet been determined; however,
it may play a role in the development of the brain and telencephalon. [provided by RefSeq]

UniProtKB/Swiss-Prot: FOXG1_HUMAN, P55316
Function: Transcription repression factor which plays an important role in the establishment of the
regional subdivision of the developing brain and in the development of the telencephalon

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q13   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q11-q13

FOXG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P028306:     (about GC identifiers)

Start:
28,304,801 bp from pter
End:
28,309,230 bp from pter
Size:
4,430 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000014.7  NT_026437.11  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: FOXG1_HUMAN, P55316 (See protein sequence)
Recommended Name: Forkhead box protein G1  
Size: 489 amino acids; 52352 Da
Subunit: Interacts with KDM5B
Subcellular location: Nucleus
Caution: PubMed:7959731 claims that there are 3 different FOXG1 proteins, FOXG1A, FOXG1B, and
FOXG1C. It was latter found that there is only one gene and the differences between these three
may be sequencing errors since the protein is coded in a unique exon
Secondary accessions: A6NFY2 P55315 Q14488 Q86XT7

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_005240.3  

    ENSEMBL proteins: 
    ENSP00000371975 ENSP00000339004 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (FOXG1)
    Human Recombinant Proteins from Abnova (FOXG1B)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus NAS--
    About this table

    Antibodies for FOXG1: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of FOXG1
    Sigma-Aldrich Antibodies for FOXG1
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (FOXG1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (FOXG1B)
    Novus Biologicals Antibodies for FOXG1

    Assays for FOXG1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR011991 Wing_hlx_DNA_bd
     IPR018122 TF_fork_head_CS
     IPR001766 TF_fork_head


       GeneDecks  FOXG1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P55316

    ProtoNet protein and cluster: P55316

    UniProtKB/Swiss-Prot: FOXG1_HUMAN, P55316
    Similarity: Contains 1 fork-head DNA-binding domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (FOXG1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (FOXG1B)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005249

                  Applied Biosystems Silencer® siRNAs for FOXG1

                  Sigma-Aldrich siRNA for FOXG1  
                         Sigma-Aldrich shRNA for FOXG1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005249
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005249
                                     untagged cDNA clone in CMV expression vector: NM_005249 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_005249

    UniProtKB/Swiss-Prot: FOXG1_HUMAN, P55316
    Function: Transcription repression factor which plays an important role in the establishment of the
    regional subdivision of the developing brain and in the development of the telencephalon

    15/21 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Foxg1) (see all 21 ):

    behavior/neurologicalcellularcraniofacialdigestive/alimentary
    embryogenesisendocrine/exocrine glandgrowth/sizehearing/vestibular/earhematopoietic system
    homeostasis/metabolismimmune systemlethality-postnatallethality-prenatal/perinatalmuscle

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700 transcription factor activity TAS--
    GO:0043565 sequence-specific DNA binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    2 Millipore Pathways for FOXG1
     Transcription factors in neurogenesis
     Signal transduction Activin A signaling regulation

       GeneDecks  FOXG1 for the pathways selected above  
    About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  FOXG1  (Your Favorite Gene powered by Ingenuity) 
     PTEN Signaling

       GeneDecks  FOXG1 for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  FOXG1 


    5/29 Interacting proteins for FOXG1 (ENSP000003390043) via UniProtKB, MINT, and/or STRING (see all 29 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD3ENSP000003329733STRING (score=.976)
    SMAD2ENSP000002621603STRING (score=.974)
    SMAD4ENSP000003415513STRING (score=.974)
    TLE1ENSP000003471023STRING (score=.973)
    ENSG00000117139ENSP000002357903STRING (score=.971)
    About this table

    5/13 Gene Ontology (GO) biological process terms (links to tree view) (see all 13 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002052 positive regulation of neuroblast proliferation IEA--
    GO:0006350 transcription IEA--
    GO:0006355 regulation of transcription, DNA-dependent NAS--
    GO:0007275 multicellular organismal development IEA--
    GO:0007346 regulation of mitotic cell cycle IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for FOXG1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (FOXG1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (FOXG1B)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005249

                  Sigma-Aldrich siRNA for FOXG1  
                         Sigma-Aldrich shRNA for FOXG1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_005249  

    REFSEQ mRNAs for FOXG1 gene: 

    NM_005249.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_005249  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005249
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005249
                                     untagged cDNA clone in CMV expression vector: NM_005249 

    Additional cDNA sequence: 

    BC050072.1 CR602240.1 X74144.1 

    5 DOTS entries:

    DT.453370  DT.91952337  DT.95269931  DT.100748690  DT.95361559 

    9 AceView cDNA sequences:

    BI915241 BX408766 BX410672 BX404748 BI913371 BG910224 BX440747 BG912675 
    BX410673 

    Unigene Clusters for FOXG1:

    Forkhead box G1
    Hs.695962  [show with all ESTs], Hs.708841  [show with all ESTs]
    Unigene Representative Sequences: NM_005249, BC050072


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000382535  ENST00000313071  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    FOXG1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for FOXG1

    1 / 2

    8 probe-sets matching FOXG1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    31947_r_at2 U95-A 1 1.00 1.00 -0.43 2.05 -- -- -- -- --

    31946_s_at2 U95-A 1 1.00 1.00 0.90 0.46 -- -- -- -- --
    39605_at2 U95-A 1 1.00 1.00 0.95 0.75 -- -- -- -- --

    65030_r_at2 U95-C 1 1.00 1.00 0.56 0.28 -- -- -- -- --

    207658_s_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --

    206018_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --

    207658_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    206018_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  FOXG1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene clusters: Hs.695962 Hs.708841

    UniProtKB/Swiss-Prot: FOXG1_HUMAN, P55316
    Tissue specificity: Expression is restricted to the neurons of the developing telencephalon

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for FOXG1 gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    FOXG11   -- forkhead box G1 98.01(n)
    100(a)
    490636  XM_547758.2  XP_547758.2 
    cow
    (Bos taurus)
    FOXG11   -- forkhead box G1 96.65(n)
    98.57(a)
    516947  XM_001249412.1  XP_001249413.1 
    rat
    (Rattus norvegicus)
    Foxg11   -- forkhead box G1 95(n)
    97.71(a)
    24370  NM_012560.2  NP_036692.1 
    mouse
    (Mus musculus)
    Foxg11, 5 12 (21.00 cM)5
    forkhead box G11, 5 95.01(n)1
    97.3(a)1
    152281  NM_008241.11  NP_032267.11 
     AK0137455  AK1323055  (see all 12)
    chicken
    (Gallus gallus)
    FOXG11   -- forkhead box G1 88.62(n)
    92.02(a)
    396110  NM_205193.1  NP_990524.1 
    About this table        Species with no ortholog for FOXG1

    ENSEMBL Gene Tree for FOXG1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for FOXG1 gene
    FOXF12  FOXQ12  FOXF22  FOXL22  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/18 NCBI SNPs in FOXG1 are shown (see all 18 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 20)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 14 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs125890131,2
    C,F,H28304359(+) CAACCG/AAACCT 1 -- ng514Minor allele frequency- A:0.06EU EA WA 418
    rs10427621,2
    --28308306(+) GCAACA/GCTGCC 1 -- ut310--------
    rs10427611,2
    --28308250(+) AATGCA/GCTTGG 1 -- ut310--------
    rs128884671,2
    --28305288(+) TACCAC/GCACCA 1 -- ng510--------
    --
    rs128934871,2
    --28305819(+) cgccgC/Tccggc 1 -- ng510--------
    --
    rs128922911,2
    --28305900(+) gcagcA/Gggggg 1 -- ng51 trp30--------
    --
    rs114337871,2
    --28307798(+) TTAAG-/CCCCCC 1 -- ut31 trp30--------
    --
    rs680241321,2
    --28307806(+) CCCCC-/CTCCCA 1 -- ut310--------
    --
    rs718057921,2
    --28307799(+) TAAGC-/CCCCCC 1 -- ut310--------
    rs11268901,2
    --28307584(+) CCTCGA/CCCCCT 1 T/P mis10--------
    About this table

    HapMap Linkage Disequilibrium images for FOXG1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 164874

    Human Gene Mutation Database: FOXG1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/36 PubMed articles for FOXG1 gene (see all 36 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 2290 HGNC: 3811 AceView: FOXG1B Ensembl:ENSG00000176165 euGenes: HUgn2290
    ECgene: FOXG1 H-InvDB: FOXG1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for FOXG1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for FOXG1 Antibodies for FOXG1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for FOXG1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Antibodies for FOXG1

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