Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FKBPL Gene

protein-coding   GIFtS: 53
GCID: GC06M032101

FK506 Binding Protein Like

(Previous name: FK506-binding protein like)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
FK506 Binding Protein Like1 2     NG72 3
WAF-1/CIP1 Stabilizing Protein 391 2 3     WISP392
FK506-Binding Protein Like1 2     FK506-Binding Protein-Like2
DIR12 3     WISp393

External Ids:    HGNC: 139491   Entrez Gene: 639432   Ensembl: ENSG000002043157   UniProtKB: Q9UIM33   

Export aliases for FKBPL gene to outside databases

Previous GC identifers: GC06U990246 GC06M032117 GC06M031867 GC06M032167 GC06M032204 GC06M032098 GC06M032099


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FKBPL Gene:
The protein encoded by this gene has similarity to the immunophilin protein family, which play a role in
immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is
thought to have a potential role in the induced radioresistance. Also it appears to have some involvement in the
control of the cell cycle. (provided by RefSeq, Jul 2008)

GeneCards Summary for FKBPL Gene:
FKBPL (FK506 binding protein like) is a protein-coding gene. Diseases associated with FKBPL include male infertility, and infertility. GO annotations related to this gene include FK506 binding and peptidyl-prolyl cis-trans isomerase activity.

UniProtKB/Swiss-Prot: FKBPL_HUMAN, Q9UIM3
Function: May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21

Gene Wiki entry for FKBPL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  NT_113891.3  NT_167245.2  NT_167247.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FKBPL gene promoter:
         SRF   RFX1   SRF (504 AA)   Olf-1   CUTL1   AREB6   POU2F1   POU2F1a   POU2F1b   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFKBPL promoter sequence
   Search Chromatin IP Primers for FKBPL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FKBPL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

FKBPL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FKBPL gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M032101:  view genomic region     (about GC identifiers)

Start:
32,096,484 bp from pter      End:
32,098,068 bp from pter
Size:
1,585 bases      Orientation:
minus strand

3 alternative locations:
Chr6-,NT_167247 3,476,312-3,477,895      Chr6-,NT_167245 3,375,656-3,377,239      Chr6-,NT_113891.2 3,567,144-3,568,727     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FKBPL_HUMAN, Q9UIM3 (See protein sequence)
Recommended Name: FK506-binding protein-like  
Size: 349 amino acids; 38176 Da
Subunit: Forms a ternary complex with CDKN1A/p21 and HSP90AB1/Hsp90
Sequence caution: Sequence=BAB15663.1; Type=Frameshift; Positions=201, 205, 319; Sequence=CAG33655.1;
Type=Frameshift; Positions=201;
Secondary accessions: A8K5V3 B0UYX8 Q9H5G3

Explore the universe of human proteins at neXtProt for FKBPL: NX_Q9UIM3

Explore proteomics data for FKBPL at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FKBPL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071393.2  
    ENSEMBL proteins: 
     ENSP00000364298  

    FKBPL Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for FKBPL
    OriGene Protein Over-expression Lysate for FKBPL
    OriGene MassSpec for FKBPL
    OriGene Custom Protein Services for FKBPL
    GenScript Custom Purified and Recombinant Proteins Services for FKBPL
    Novus Biologicals FKBPL Proteins
    Novus Biologicals FKBPL Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for FKBPL
    Cloud-Clone Corp. Proteins for FKBPL

    FKBPL Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of FKBPL
    Browse R&D Systems for Antibodies
    OriGene Antibodies for FKBPL
    OriGene Custom Antibody Services for FKBPL
    Novus Biologicals FKBPL Antibodies
    Abcam antibodies for FKBPL
    Cloud-Clone Corp. Antibodies for FKBPL
    ThermoFisher Antibody for FKBPL
    LSBio Antibodies in human, mouse, rat for FKBPL

    FKBPL Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FKBPL
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FKBPL
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FKBPL
    Cloud-Clone Corp. CLIAs for FKBPL


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    TTC: Tetratricopeptide (TTC) repeat domain containing

    5 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR023566 PPIase_FKBP
     IPR001440 TPR_1
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry Q9UIM3

    ProtoNet protein and cluster: Q9UIM3

    UniProtKB/Swiss-Prot: FKBPL_HUMAN, Q9UIM3
    Similarity: Contains 3 TPR repeats


    FKBPL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FKBPL_HUMAN, Q9UIM3
    Function: May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity IBA--
    GO:0005515protein binding ----
    GO:0005528FK506 binding IBA--
         
    FKBPL for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Fkbpl (no phenotypes)

    FKBPL for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FKBPL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FKBPL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FKBPL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FKBPL

    miRNA
    Products:
        
    miRTarBase miRNAs that target FKBPL:
    hsa-mir-92a-3p (MIRT049580), hsa-mir-183-5p (MIRT047053)

    Block miRNA regulation of human, mouse, rat FKBPL using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate FKBPL
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FKBPL
    Predesigned siRNA for gene silencing in human, mouse, rat FKBPL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FKBPL

    Clone
    Products:
         
    OriGene clones in human, mouse for FKBPL (see all 6)
    OriGene ORF clones in mouse, rat for FKBPL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FKBPL (NM_022110)
    Sino Biological Human cDNA Clone for FKBPL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FKBPL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FKBPL

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FKBPL
    Browse ESI BIO Cell Lines and PureStem Progenitors for FKBPL 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBPL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    cytoskeleton1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--
    GO:0016020membrane IBA--

    FKBPL for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FKBPL
    Interactions:

        GeneGlobe Interaction Network for FKBPL

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for FKBPL (Q9UIM32, 3 ENSP000003642984) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UNC119Q134322, 3MINT-65750 I2D: score=5 
    CDKN1AP389363I2D: score=1 
    HSP90AA1P079003I2D: score=1 
    TRAF1Q130773I2D: score=1 
    RUVBL1ENSP000003182974STRING: ENSP00000318297
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000413protein peptidyl-prolyl isomerization IBA--
    GO:0009314response to radiation NAS10521921
    GO:0018208peptidyl-proline modification IBA--

    FKBPL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FKBPL



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FKBPL gene: 
    NM_022110.3  

    Unigene Cluster for FKBPL:

    FK506 binding protein like
    Hs.520042  [show with all ESTs]
    Unigene Representative Sequence: AK291418
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000375156(uc003nzr.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FKBPL using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate FKBPL
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FKBPL
    Predesigned siRNA for gene silencing in human, mouse, rat FKBPL
    Clone
    Products:
         
    OriGene clones in human, mouse for FKBPL (see all 6)
    OriGene ORF clones in mouse, rat for FKBPL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FKBPL (NM_022110)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FKBPL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FKBPL
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FKBPL
    OriGene qSTAR qPCR primer pairs in human, mouse for FKBPL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FKBPL
      QuantiTect SYBR Green Assays in human, mouse, rat FKBPL
      QuantiFast Probe-based Assays in human, mouse, rat FKBPL

    Additional mRNA sequence: 

    AK027119.1 AK291418.1 BC004168.2 BC011966.1 CR457374.1 

    2 DOTS entries:

    DT.412603  DT.100001020 

    Selected AceView cDNA sequences (see all 77):

    BE045958 BC004168 CA489826 BU625175 CD364908 AI655575 AA617889 BU783101 
    BX385692 CA420516 BE889603 BM668065 NM_022110 AA447685 AI356728 BX107524 
    AI342157 AA476572 AA448894 BM977518 AA535543 AI193537 AI656025 BU628150 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FKBPL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAATCTGGC
    FKBPL Expression
    About this image

    FKBPL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FKBPL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.520042

    UniProtKB/Swiss-Prot: FKBPL_HUMAN, Q9UIM3
    Tissue specificity: Ubiquitously expressed with higher levels in testis

        Custom PCR Arrays for FKBPL
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FKBPL
    OriGene qSTAR qPCR primer pairs in human, mouse for FKBPL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FKBPL
    QuantiTect SYBR Green Assays in human, mouse, rat FKBPL
    QuantiFast Probe-based Assays in human, mouse, rat FKBPL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBPL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for FKBPL gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fkbpl1 , 5 FK506 binding protein-like1, 5 81.21(n)1
    73.99(a)1
      17 (18.22 cM)5
    562991  NM_019873.21  NP_063926.11 
     346447645 
    lizard
    (Anolis carolinensis)
    Reptilia FKBPL6
    FK506 binding protein like
    52(a)
    1 ↔ 1
    2(194768922-194769614)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fkbpl1 FK506 binding protein like 47.33(n)
    39.6(a)
      100488483  XM_002941260.1  XP_002941306.1 
    zebrafish
    (Danio rerio)
    Actinopterygii FKBPL6
    FK506 binding protein like
    25(a)
    1 ↔ 1
    23(19394606-19407993) ENSDARG00000095322


    ENSEMBL Gene Tree for FKBPL (if available)
    TreeFam Gene Tree for FKBPL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FKBPL (see all 26)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs119623531,2
    C,F,H--31854155(+) GACCTG/ACTCCA 1 -- us2k18Minor allele frequency- A:0.02NS EA WA 1206
    rs803472881,2
    C--32098022(+) GAGGCG/AGGGGT 1 -- ut512Minor allele frequency- A:0.08WA 120
    rs1172429371,2
    C,F--32098202(+) ACTGAA/TCTAGG 1 -- us2k11Minor allele frequency- T:0.15EA 120
    rs1447812611,2
    C--32098229(+) AGGCAA/GAATCG 1 -- us2k10--------
    rs1397844011,2
    --32098319(+) AAAAAC/TACAAA 1 -- us2k10--------
    rs802291811,2
    C--32098482(+) CGTCTC/GAAACA 1 -- us2k10--------
    rs49472541,2
    C--32098485(+) ctcaaA/Ccaaaa 1 -- us2k10--------
    rs1430387711,2
    C--32098975(+) ACTGCA/TATCCA 1 -- us2k10--------
    rs1461932171,2
    --32098978(+) GCAATA/CCAGCC 1 -- us2k10--------
    rs752141691,2
    C,F--32099004(+) ATTCCC/TGCCTC 1 -- us2k11Minor allele frequency- T:0.04NA 120

    HapMap Linkage Disequilibrium report for FKBPL (32096484 - 32098068 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FKBPL:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv884702CNV Loss21882294
    nsv830629CNV Loss17160897
    nsv884701CNV Gain21882294
    dgv1929e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): FKBPL
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FKBPL
    DNA2.0 Custom Variant and Variant Library Synthesis for FKBPL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    5 diseases for FKBPL:    
    About MalaCards
    male infertility    infertility    systemic lupus erythematosus    age related macular degeneration
    lupus erythematosus


    FKBPL for disorders           About GeneDecksing

    Genetic Association Database (GAD): FKBPL
    Human Genome Epidemiology (HuGE) Navigator: FKBPL (3 documents)

    Export disorders for FKBPL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FKBPL gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with FKBPL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human stress response-related gene with a potential role in induced radioresistance. (PubMed id 10521921)1, 2, 9 Robson T.... Hirst D.G. (Radiat. Res. 1999)
    2. Alterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study. (PubMed id 20210997)1, 4 Sunnotel O....Walsh C.P. (amp 2010)
    3. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
    4. Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein. (PubMed id 15664193)1, 2 Jascur T.... Fotedar A. (Mol. Cell 2005)
    5. Gene regulation by low-dose ionizing radiation in a normal human lung epithelial cell line. (PubMed id 9056895)1, 3 Robson T.A....Arrand J.E. (Biochem. Soc. Trans. 1997)
    6. A novel FK506-like binding protein interacts with the glucocorticoid receptor and regulates steroid receptor signaling. (PubMed id 18669603)1, 9 McKeen H.D....Robson T. (Endocrinology 2008)
    7. FKBPL regulates estrogen receptor signaling and determines response to endocrine therapy. (PubMed id 20103631)1, 9 McKeen H.D....Robson T. (Cancer Res. 2010)
    8. The anti-migratory effects of FKBPL and its peptide derivative, AD-01: regulation of CD44 and the cytoskeletal pathway. (PubMed id 23457460)1 Yakkundi A....Robson T. (PLoS ONE 2013)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (Nat. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 63943 HGNC: 13949 AceView: FKBPL Ensembl:ENSG00000204315 euGenes: HUgn63943
    ECgene: FKBPL H-InvDB: FKBPL

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FKBPL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FKBPL gene:
    Search GeneIP for patents involving FKBPL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of FKBPL
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for FKBPL   OriGene RNAi products in human, mouse, rat for FKBPL  
     OriGene qPCR primer pairs and template standards for FKBPL   OriGene Protein Over-expression Lysate for FKBPL  
     OriGene MassSpec something-or-other for FKBPL   OriGene clones in human, mouse for FKBPL  
     OriGene qSTAR qPCR primer pairs in human, mouse for FKBPL   OriGene Purified Protein for FKBPL  
     OriGene ORF clones in mouse, rat for FKBPL   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FKBPL   OriGene Custom Protein Services for FKBPL  

     
     
     Block miRNA regulation of human, mouse, rat FKBPL using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FKBPL
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FKBPL Predesigned siRNA for gene silencing in human, mouse, rat FKBPL
     QuantiFast Probe-based Assays in human, mouse, rat FKBPL QuantiTect SYBR Green Assays in human, mouse, rat FKBPL
     Custom PCR Arrays for FKBPL Search Chromatin IP Primers for FKBPL
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FKBPL  GeneGlobe Interaction Network for FKBPL
     Regulatory tfbs in FKBPL promoter
     GenScript Custom Purified and Recombinant Proteins Services for FKBPL GenScript cDNA clones with any tag delivered in your preferred vector for FKBPL
     GenScript Custom Assay Services for FKBPL GenScript Custom overexpressing Cell Line Services for FKBPL
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FKBPL
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for FKBPL
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FKBPL antibodies
     FKBPL proteins
     FKBPL lysates
     Antibodies for FKBPL
     See all of Abcam's Antibodies, Kits and Proteins for FKBPL
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for FKBPL
     Proteins for FKBPL
     Antibodies for FKBPL
     ELISAs for FKBPL
     CLIAs for FKBPL



     Browse ESI BIO Cell Lines and PureStem Progenitors for FKBPL
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBPL
     Browse SwitchGear 3'UTR luciferase reporter plasmids for FKBPL
     SwitchGear Promoter luciferase reporter plasmids for FKBPL
     ThermoFisher Antibody for FKBPL
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FKBPL
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FKBPL
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FKBPL
     LSBio Antibodies in human, mouse, rat for FKBPL
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FKBPL gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4