FKBPL Gene
protein-coding GIFtS: 48
GCID: GC06M032099
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FK506 binding protein like(Previous name: FK506-binding protein like )
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Aliases
for FKBPL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| FK506 Binding Protein Like1 2 | | WAF-1/CIP1 Stabilizing Protein 392 3 | | DIR11 2 3 | | WISP392 | | NG71 2 3 | | FK506-Binding Protein-Like2 | | FK506-Binding Protein Like1 2 | | WISp393 |
Export aliases for FKBPL gene to outside databasesPrevious GC identifers: GC06U990246 GC06M032117 GC06M031867 GC06M032167 GC06M032204 GC06M032098 |
Summaries
for FKBPL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FKBPL:
The protein encoded by this gene has similarity to the immunophilin protein family, which play a role inimmunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein isthought to have a potential role in the induced radioresistance. Also it appears to have some involvement in thecontrol of the cell cycle. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: FKBPL_HUMAN, Q9UIM3Function: May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21
Gene Wiki entry for FKBPL
|
Genomic Views
for FKBPL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167245.1 NT_167247.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FKBPL gene promoter:
SRF RFX1 SRF (504 AA) Olf-1 CUTL1 AREB6 POU2F1 POU2F1a POU2F1b POU2F1c
Other transcription factors
Search SABiosciences Chromatin IP Primers for FKBPL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FKBPL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21.3FKBPL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M032099: view genomic region
(about GC identifiers)
Start:
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32,096,484 bp from pter |
End:
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32,098,068 bp from pter |
Size:
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1,585 bases |
Orientation:
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minus strand |
3 alternative locations:
| Chr6-,ALT_REF_LOCI_3 32,072,259-32,084,880 | Chr6-,ALT_REF_LOCI_5 32,087,735-32,089,318 | Chr6-,ALT_REF_LOCI_2 32,044,940-32,085,711 | |
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Proteins
for FKBPL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FKBPL_HUMAN, Q9UIM3 (See
protein sequence)Recommended Name: FK506-binding protein-like Size: 349 amino acids; 38176 Da
Subunit: Forms a ternary complex with CDKN1A/p21 and HSP90AB1/Hsp90
Sequence caution: Sequence=BAB15663.1; Type=Frameshift; Positions=201, 205, 319; Sequence=CAG33655.1; Type=Frameshift;Positions=201;
Secondary accessions: A8K5V3 B0UYX8 Q9H5G3Explore the universe of human proteins at neXtProt for FKBPL: NX_Q9UIM3
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UIM3
FKBPL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_071393.2
ENSEMBL proteins: ENSP00000364298
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
FKBPL for ontologies About GeneDecksing
FKBPL Antibody Products:
Assay Products for FKBPL: |
Protein
Domains /
Families
for FKBPL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FKBPL for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UIM3ProtoNet protein and cluster: Q9UIM3 UniProtKB/Swiss-Prot: FKBPL_HUMAN, Q9UIM3Similarity: Contains 3 TPR repeats |
Function
for FKBPL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FKBPL_HUMAN, Q9UIM3Function: May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FKBPL (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FKBPL (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for FKBPL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FKBPL |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBPL |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003755 | peptidyl-prolyl cis-trans isomerase activity |
IBA | -- | | GO:0005528 | FK506 binding |
IBA | -- |
FKBPL for ontologies About GeneDecksing
|
Pathways & Interactions
for FKBPL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FKBPL
4 Interacting proteins for FKBPL (Q9UIM32, 3) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
FKBPL for ontologies About GeneDecksing
|
Drugs & Compounds
for FKBPL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FKBPL
Search CenterWatch for drugs/clinical trials and news about FKBPL
|
Transcripts
for FKBPL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FKBPL gene: NM_022110.3 Unigene Cluster for FKBPL: FK506 binding protein like Hs.520042 [show with all ESTs]Unigene Representative Sequence: AK2914181 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000375156(uc003nzr.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FKBPL (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FKBPL (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FKBPL (NM_022110) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FKBPL | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FKBPL |
Additional cDNA sequence: AK027119.1 AK291418.1 BC004168.2 BC011966.1 CR457374.1 2 DOTS entries: DT.412603 DT.100001020 24/77 AceView cDNA sequences (see all 77): BX385692 BM668065 AA617889 AI655575 BX107524 AA476572 BE045958 NM_022110 CA420516 BU783101 BC004168 AI342157 AI356728 CD364908 BU625175 AA447685 BE889603 CA489826 AI193537 CR457374 BM981405 AW137118 BM977518 BU628150
GeneLoc Exon Structure
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Expression
for FKBPL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FKBPL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAATCTGGC
About this image
See FKBPL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FKBPL
SOURCE GeneReport for Unigene cluster: Hs.520042
UniProtKB/Swiss-Prot: FKBPL_HUMAN, Q9UIM3Tissue specificity: Ubiquitously expressed with higher levels in testis
SABiosciences Custom PCR Arrays for FKBPL
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FKBPL
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBPL |
Orthologs
for FKBPL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FKBPL gene from 2/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
FKBPL6 |
-- |
47(a) |
1 ↔ 1 |
2(194768922-194769614) |
zebrafish
(Danio rerio) |
Actinopterygii |
si:ch73-381f5.36 |
si:ch73-381f5.3 |
24(a) |
1 ↔ 1 |
23(19394606-19407993) |
ENSEMBL Gene Tree for FKBPL (if available)
TreeFam Gene Tree for FKBPL (if available) |
Paralogs
for FKBPL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for FKBPL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FKBPL (32096484 - 32098068 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FKBPL
1 CNV: 3602
Human Gene Mutation Database (HGMD): FKBPL
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FKBPL |
|
Disorders
/ Diseases
for FKBPL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FKBPL for disorders About GeneDecksing
4  diseases for FKBPL: About MalaCardssystemic lupus erythematosus lupus erythematosus male infertility infertility
Human Genome Epidemiology (HuGE) Navigator: FKBPL (3 documents)
Export disorders for FKBPL gene to outside databases
|
Publications
for FKBPL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FKBPL gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with FKBPL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel human stress response-related gene with a potential role in induced radioresistance. (PubMed id 10521921)1, 2, 9 Robson T.... Hirst D.G. (1999)
- Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein. (PubMed id 15664193)1, 2 Jascur T.... Fotedar A. (2005)
- Gene regulation by low-dose ionizing radiation in a normal human lung epithelial cell line. (PubMed id 9056895)1, 3 Robson T.A....Arrand J.E. (1997)
- A novel FK506-like binding protein interacts with the glucocorticoid receptor and regulates steroid receptor signaling. (PubMed id 18669603)1, 9 McKeen H.D....Robson T. (2008)
- FKBPL regulates estrogen receptor signaling and deter mines response to endocrine therapy. (PubMed id 20103631)1, 9 McKeen H.D....Robson T. (2010)
- Genome-wide association study of age-related macular d egeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of ch romosome 6p21.3. (PubMed id 22694956)1 Cipriani V....Yates J.R. (2012)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Alterations in the steroid hormone receptor co-chaper one FKBPL are associated with male infertility: a case-control study. (PubMed id 20210997)1 Sunnotel O....Walsh C.P. (2010)
- High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1 Barcellos L.F....Criswell L.A. (2009)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
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External Searches for FKBPL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing FKBPL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FKBPL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FKBPL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FKBPL | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FKBPL gene:
Search GeneIP for patents involving FKBPL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FKBPL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for FKBPL | | OriGene shRNA RFP for FKBPL | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FKBPL | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FKBPL | | | OriGene Protein Over-expression Lysate for FKBPL | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FKBPL | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FKBPL | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FKBPL | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FKBPL | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FKBPL | | OriGene Custom Protein Services for FKBPL | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FKBPL | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FKBPL | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FKBPL | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FKBPL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FKBPL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FKBPL |
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 | | | FKBPL Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBPL |
|  |  |  | | | | ThermoFisher Antibody for FKBPL |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FKBPL |
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