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Aliases for FKBPL Gene

Aliases for FKBPL Gene

  • FK506 Binding Protein Like 2 3 5
  • WAF-1/CIP1 Stabilizing Protein 39 2 3 4
  • WISP39 3 4
  • DIR1 3 4
  • NG7 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase 3
  • FK506-Binding Protein Like 2
  • FK506-Binding Protein-Like 3
  • FKBP4 3

External Ids for FKBPL Gene

Previous GeneCards Identifiers for FKBPL Gene

  • GC06U990246
  • GC06M032117
  • GC06M031867
  • GC06M032167
  • GC06M032204
  • GC06M032098
  • GC06M032099

Summaries for FKBPL Gene

Entrez Gene Summary for FKBPL Gene

  • The protein encoded by this gene has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thought to have a potential role in the induced radioresistance. Also it appears to have some involvement in the control of the cell cycle. [provided by RefSeq, Jul 2008]

GeneCards Summary for FKBPL Gene

FKBPL (FK506 Binding Protein Like) is a Protein Coding gene. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Regulation of PLK1 Activity at G2/M Transition. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and FK506 binding.

UniProtKB/Swiss-Prot for FKBPL Gene

  • May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.

Gene Wiki entry for FKBPL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBPL Gene

Genomics for FKBPL Gene

Regulatory Elements for FKBPL Gene

Enhancers for FKBPL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F032075 0.8 Ensembl ENCODE 11.5 +53.8 53846 1.8 ZNF639 ZNF362 ZNF280D HLF NFRKB CEBPB ZFP37 ZKSCAN1 PATZ1 GLIS1 TNXB ATF6B FKBPL PPT2 PRRT1 EGFL8 AGPAT1 MIR6721 RNF5 RNA5SP206
GH06F032126 0.4 ENCODE 11 +1.2 1215 4.5 PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 VARS LSM2 MICA DDX39B LY6G5B BRD2 ATF6B SKIV2L BAG6 PPT2
GH06F032243 0.8 Ensembl ENCODE 10.9 -114.4 -114400 1.4 ZNF493 ARID4B ZNF48 ZNF2 ZNF121 GLIS2 ZNF143 KLF7 ZNF202 NCOA1 LY6G5B BRD2 ATF6B PPT2 DDX39B LSM2 NFKBIL1 EGFL8 RXRB HLA-DRB1
GH06F032080 1.2 FANTOM5 Ensembl ENCODE 10.6 +47.8 47808 3.9 HDGF ATF1 PKNOX1 ARID4B DMAP1 ZNF2 ZNF48 SLC30A9 GLIS2 ZNF143 HLA-DRB1 ATF6B CYP21A1P FKBPL TNXB PPT2 LY6G6C RNA5SP206
GH06F031907 0.8 Ensembl ENCODE 10.3 +220.7 220708 5.2 PKNOX1 ARID4B GTF3C2 ZNF121 GLIS2 KLF7 FOS ZNF263 NFYC MXD4 SKIV2L VARS LY6G5B LSM2 C4A RNU6-850P DDX39B ATF6B CSNK2B GPANK1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FKBPL on UCSC Golden Path with GeneCards custom track

Promoters for FKBPL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000264509 -92 1601 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207

Genomic Location for FKBPL Gene

Chromosome:
6
Start:
32,128,707 bp from pter
End:
32,130,308 bp from pter
Size:
1,602 bases
Orientation:
Minus strand

Genomic View for FKBPL Gene

Genes around FKBPL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FKBPL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FKBPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBPL Gene

Proteins for FKBPL Gene

  • Protein details for FKBPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIM3-FKBPL_HUMAN
    Recommended name:
    FK506-binding protein-like
    Protein Accession:
    Q9UIM3
    Secondary Accessions:
    • A8K5V3
    • B0UYX8
    • Q9H5G3

    Protein attributes for FKBPL Gene

    Size:
    349 amino acids
    Molecular mass:
    38176 Da
    Quaternary structure:
    • Forms a ternary complex with CDKN1A/p21 and HSP90AB1/Hsp90.
    SequenceCaution:
    • Sequence=BAB15663.1; Type=Frameshift; Positions=201, 205, 319; Evidence={ECO:0000305}; Sequence=CAG33655.1; Type=Frameshift; Positions=201; Evidence={ECO:0000305};

neXtProt entry for FKBPL Gene

Post-translational modifications for FKBPL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FKBPL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FKBPL Gene

Domains & Families for FKBPL Gene

Protein Domains for FKBPL Gene

Suggested Antigen Peptide Sequences for FKBPL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UIM3

UniProtKB/Swiss-Prot:

FKBPL_HUMAN :
  • Contains 3 TPR repeats.
Similarity:
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with FKBPL: view

Function for FKBPL Gene

Molecular function for FKBPL Gene

UniProtKB/Swiss-Prot Function:
May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.

Gene Ontology (GO) - Molecular Function for FKBPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0005515 protein binding IPI 25036637
GO:0005528 FK506 binding IBA --
genes like me logo Genes that share ontologies with FKBPL: view
genes like me logo Genes that share phenotypes with FKBPL: view

Animal Models for FKBPL Gene

MGI Knock Outs for FKBPL:

Animal Model Products

miRNA for FKBPL Gene

miRTarBase miRNAs that target FKBPL

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FKBPL Gene

Localization for FKBPL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FKBPL Gene COMPARTMENTS Subcellular localization image for FKBPL gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FKBPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FKBPL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FKBPL Gene

Pathways & Interactions for FKBPL Gene

genes like me logo Genes that share pathways with FKBPL: view

Gene Ontology (GO) - Biological Process for FKBPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0009314 response to radiation NAS 10521921
GO:0050821 protein stabilization TAS --
GO:0061077 chaperone-mediated protein folding IBA --
genes like me logo Genes that share ontologies with FKBPL: view

No data available for SIGNOR curated interactions for FKBPL Gene

Transcripts for FKBPL Gene

mRNA/cDNA for FKBPL Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(77) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FKBPL Gene

FK506 binding protein like:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FKBPL Gene

No ASD Table

Relevant External Links for FKBPL Gene

GeneLoc Exon Structure for
FKBPL
ECgene alternative splicing isoforms for
FKBPL

Expression for FKBPL Gene

mRNA expression in normal human tissues for FKBPL Gene

Protein differential expression in normal tissues from HIPED for FKBPL Gene

This gene is overexpressed in Peripheral blood mononuclear cells (35.8), CD8 Tcells (9.1), Pancreas (7.9), Testis (7.5), and Urinary Bladder (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FKBPL Gene



Protein tissue co-expression partners for FKBPL Gene

NURSA nuclear receptor signaling pathways regulating expression of FKBPL Gene:

FKBPL

SOURCE GeneReport for Unigene cluster for FKBPL Gene:

Hs.520042

mRNA Expression by UniProt/SwissProt for FKBPL Gene:

Q9UIM3-FKBPL_HUMAN
Tissue specificity: Ubiquitously expressed with higher levels in testis.
genes like me logo Genes that share expression patterns with FKBPL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FKBPL Gene

Orthologs for FKBPL Gene

This gene was present in the common ancestor of chordates.

Orthologs for FKBPL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FKBPL 34 35
  • 99.81 (n)
dog
(Canis familiaris)
Mammalia FKBPL 34
  • 86.63 (n)
mouse
(Mus musculus)
Mammalia Fkbpl 34 16 35
  • 81.21 (n)
cow
(Bos Taurus)
Mammalia FKBPL 35
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fkbpl 34
  • 80.92 (n)
lizard
(Anolis carolinensis)
Reptilia FKBPL 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fkbpl 34
  • 47.33 (n)
zebrafish
(Danio rerio)
Actinopterygii FKBPL 35
  • 25 (a)
OneToOne
Species where no ortholog for FKBPL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FKBPL Gene

ENSEMBL:
Gene Tree for FKBPL (if available)
TreeFam:
Gene Tree for FKBPL (if available)

Paralogs for FKBPL Gene

No data available for Paralogs for FKBPL Gene

Variants for FKBPL Gene

Sequence variations from dbSNP and Humsavar for FKBPL Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs113427579 -- 32,128,556(+) CCTCG(G/T)AGATA downstream-variant-500B, upstream-variant-2KB
rs115056115 -- 32,132,053(+) TTTTT(C/T)TTTTT upstream-variant-2KB
rs116213010 -- 32,131,856(+) CTTTC(A/T)CATCC upstream-variant-2KB
rs117160266 -- 32,129,698(+) CAAGG(C/T)TCTCC upstream-variant-2KB, reference, missense
rs117242937 -- 32,130,425(+) ACTGA(A/T)CTAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FKBPL Gene

Variant ID Type Subtype PubMed ID
dgv10404n54 CNV loss 21841781
dgv10463n54 CNV loss 21841781
dgv10472n54 CNV loss 21841781
esv2759415 CNV gain+loss 17122850
nsv1028506 CNV gain 25217958
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv602104 CNV loss 21841781
nsv830629 CNV loss 17160897

Variation tolerance for FKBPL Gene

Residual Variation Intolerance Score: 32.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.24; 76.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FKBPL Gene

Human Gene Mutation Database (HGMD)
FKBPL
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FKBPL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FKBPL Gene

Disorders for FKBPL Gene

Relevant External Links for FKBPL

Genetic Association Database (GAD)
FKBPL
Human Genome Epidemiology (HuGE) Navigator
FKBPL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FKBPL

No disorders were found for FKBPL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FKBPL Gene

Publications for FKBPL Gene

  1. A novel human stress response-related gene with a potential role in induced radioresistance. (PMID: 10521921) Robson T. … Hirst D.G. (Radiat. Res. 1999) 3 4 22 64
  2. Alterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study. (PMID: 20210997) Sunnotel O. … Walsh C.P. (Reprod. Biol. Endocrinol. 2010) 3 46 64
  3. FKBPL regulates estrogen receptor signaling and determines response to endocrine therapy. (PMID: 20103631) McKeen H.D. … Robson T. (Cancer Res. 2010) 3 22 64
  4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 46 64
  5. A novel FK506-like binding protein interacts with the glucocorticoid receptor and regulates steroid receptor signaling. (PMID: 18669603) McKeen H.D. … Robson T. (Endocrinology 2008) 3 22 64

Products for FKBPL Gene

Sources for FKBPL Gene

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