Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FKBP9 Gene

Aliases for FKBP9 Gene

  • FK506 Binding Protein 9 2 3 5
  • FK506 Binding Protein 9, 63 KDa 2 3
  • 63 KDa FK506-Binding Protein 3 4
  • PPIase FKBP9 3 4
  • 63 KDa FKBP 3 4
  • EC 4 61
  • Rotamase 3 4
  • FKBP-63 3 4
  • FKBP-9 3 4
  • FKBP60 3 4
  • FKBP63 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase FKBP9 3
  • FK506-Binding Protein 9 (63 KD) 2
  • FK506-Binding Protein 9 4
  • PPIASE 3

External Ids for FKBP9 Gene

Previous GeneCards Identifiers for FKBP9 Gene

  • GC07M055212
  • GC07M055456
  • GC07M055491
  • GC07P032739
  • GC07P032770
  • GC07P032963
  • GC07P032997
  • GC07P032875

Summaries for FKBP9 Gene

GeneCards Summary for FKBP9 Gene

FKBP9 (FK506 Binding Protein 9) is a Protein Coding gene. Among its related pathways are Chaperonin-mediated protein folding and Metabolism of proteins. GO annotations related to this gene include calcium ion binding and FK506 binding. An important paralog of this gene is FKBP10.

UniProtKB/Swiss-Prot for FKBP9 Gene

  • PPIases accelerate the folding of proteins during protein synthesis.

Gene Wiki entry for FKBP9 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBP9 Gene

Genomics for FKBP9 Gene

Regulatory Elements for FKBP9 Gene

Enhancers for FKBP9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F032489 1.2 ENCODE 24.4 -466.9 -466866 2.4 PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 FKBP9 LSM5 LOC100130673 DPY19L1P1 ENSG00000273014 RP9 SLC25A5P5
GH07F033060 1.1 ENCODE 25.9 +105.0 105018 3.0 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 KLF13 NT5C3A FKBP9 LSM5 RN7SL505P
GH07F032905 1.6 FANTOM5 Ensembl ENCODE 15.3 -51.6 -51556 1.7 PKNOX1 ATF1 ARNT SIN3A ELK1 ZHX2 SREBF1 RFX3 SMARCA4 KDM1A FKBP9 KBTBD2 LSM5 RP9P
GH07F033128 1 ENCODE 15.2 +172.1 172056 2.1 HDGF ATF1 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ETS1 YY1 GLIS2 FKBP9 LSM5 BBS9 RNA5SP229
GH07F033038 1.2 Ensembl ENCODE 12.6 +84.8 84841 8.3 ELF3 TBP ATF1 TBL1XR1 SIN3A ARID4B RAD21 YY1 CREM ZNF362 NT5C3A FKBP9 RP9P RP9 RN7SL505P GC07M033036
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FKBP9 on UCSC Golden Path with GeneCards custom track

Promoters for FKBP9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000624387 197 2000 ATF1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 ZNF121 GLIS2 KLF13 ZNF263

Genomic Location for FKBP9 Gene

32,957,404 bp from pter
33,006,931 bp from pter
49,528 bases
Plus strand

Genomic View for FKBP9 Gene

Genes around FKBP9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FKBP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FKBP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP9 Gene

Proteins for FKBP9 Gene

  • Protein details for FKBP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP9
    Protein Accession:
    Secondary Accessions:
    • B3KY35
    • B7Z1G9
    • B7Z6H3
    • Q2M2A1
    • Q3MIR7
    • Q6IN76
    • Q6P2N1
    • Q96EX5
    • Q96IJ9

    Protein attributes for FKBP9 Gene

    570 amino acids
    Molecular mass:
    63084 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FKBP9 Gene


neXtProt entry for FKBP9 Gene

Selected DME Specific Peptides for FKBP9 Gene


Post-translational modifications for FKBP9 Gene

Other Protein References for FKBP9 Gene

Domains & Families for FKBP9 Gene

Protein Domains for FKBP9 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 EF-hand domains.
  • Contains 2 EF-hand domains.
  • Contains 4 PPIase FKBP-type domains.
genes like me logo Genes that share domains with FKBP9: view

Function for FKBP9 Gene

Molecular function for FKBP9 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by FK506.
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins during protein synthesis.

Enzyme Numbers (IUBMB) for FKBP9 Gene

Gene Ontology (GO) - Molecular Function for FKBP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA,IBA --
GO:0005509 calcium ion binding IEA,ISS --
GO:0005528 FK506 binding IBA --
GO:0016853 isomerase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FKBP9: view
genes like me logo Genes that share phenotypes with FKBP9: view

Animal Models for FKBP9 Gene

MGI Knock Outs for FKBP9:

Animal Model Products

  • Taconic Biosciences Mouse Models for FKBP9

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FKBP9 Gene

Localization for FKBP9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP9 Gene

Endoplasmic reticulum.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FKBP9 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FKBP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum ISS --
GO:0005789 endoplasmic reticulum membrane IBA --
genes like me logo Genes that share ontologies with FKBP9: view

Pathways & Interactions for FKBP9 Gene

genes like me logo Genes that share pathways with FKBP9: view

Gene Ontology (GO) - Biological Process for FKBP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0006457 protein folding IEA,ISS --
GO:0061077 chaperone-mediated protein folding IBA --
genes like me logo Genes that share ontologies with FKBP9: view

No data available for SIGNOR curated interactions for FKBP9 Gene

Transcripts for FKBP9 Gene

Unigene Clusters for FKBP9 Gene

FK506 binding protein 9, 63 kDa:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP9 Gene

No ASD Table

Relevant External Links for FKBP9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FKBP9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FKBP9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FKBP9 Gene

This gene is overexpressed in Bone marrow stromal cell (26.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FKBP9 Gene

Protein tissue co-expression partners for FKBP9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FKBP9 Gene:


SOURCE GeneReport for Unigene cluster for FKBP9 Gene:

genes like me logo Genes that share expression patterns with FKBP9: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FKBP9 Gene

Orthologs for FKBP9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FKBP9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FKBP9 34 35
  • 99.77 (n)
(Ornithorhynchus anatinus)
Mammalia FKBP9 35
  • 92 (a)
(Bos Taurus)
Mammalia FKBP9 34 35
  • 91.59 (n)
(Canis familiaris)
Mammalia FKBP9 34 35
  • 91.55 (n)
(Rattus norvegicus)
Mammalia Fkbp9 34
  • 88.44 (n)
(Mus musculus)
Mammalia Fkbp9 34 16 35
  • 87.91 (n)
(Monodelphis domestica)
Mammalia FKBP9 35
  • 87 (a)
(Gallus gallus)
Aves FKBP9 34 35
  • 76.81 (n)
(Anolis carolinensis)
Reptilia FKBP9 35
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fkbp9 34
  • 72.74 (n)
Str.10967 34
(Danio rerio)
Actinopterygii fkbp9 34 35
  • 67.66 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14715 35
  • 41 (a)
(Caenorhabditis elegans)
Secernentea fkb-5 34 35
  • 47.42 (n)
fkb-3 35
  • 33 (a)
fkb-4 35
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPR2 35
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5986 35
  • 42 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12333 34
Species where no ortholog for FKBP9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FKBP9 Gene

Gene Tree for FKBP9 (if available)
Gene Tree for FKBP9 (if available)

Paralogs for FKBP9 Gene

Paralogs for FKBP9 Gene Pseudogenes for FKBP9 Gene

genes like me logo Genes that share paralogs with FKBP9: view

Variants for FKBP9 Gene

Sequence variations from dbSNP and Humsavar for FKBP9 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10142 -- 33,006,585(+) CTGAG(C/T)ATCAA utr-variant-3-prime
rs10237603 -- 32,967,245(+) aaaaa(A/C)catca intron-variant
rs10238528 -- 32,957,131(+) ACGTA(A/G)GAGCC upstream-variant-2KB
rs10251280 -- 32,960,272(+) accac(A/G)cctgg intron-variant
rs10255445 -- 32,961,530(+) ATTta(C/T)aaaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FKBP9 Gene

Variant ID Type Subtype PubMed ID
nsv981447 CNV duplication 23825009
nsv436907 CNV insertion 17901297
nsv1135982 CNV deletion 24896259
nsv1128310 CNV deletion 24896259
nsv1033096 CNV loss 25217958
nsv1029220 CNV gain 25217958
esv3612750 OTHER inversion 21293372
esv2734229 CNV deletion 23290073
esv27091 CNV gain+loss 19812545
dgv1080e201 CNV deletion 23290073

Variation tolerance for FKBP9 Gene

Residual Variation Intolerance Score: 73.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FKBP9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FKBP9 Gene

Disorders for FKBP9 Gene

Relevant External Links for FKBP9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FKBP9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FKBP9 Gene

Publications for FKBP9 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PMID: 12754519) Zhang H. … Aebersold R. (Nat. Biotechnol. 2003) 3 4 64
  3. Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family. (PMID: 12036304) Patterson C.E. … Davis E.C. (Genomics 2002) 2 3 64
  4. Biochemical analysis of mouse FKBP60, a novel member of the FKBP family. (PMID: 10524204) Shadidy M. … Krauss S. (Biochim. Biophys. Acta 1999) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for FKBP9 Gene

Sources for FKBP9 Gene

Loading form....