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Aliases for FKBP9 Gene

Aliases for FKBP9 Gene

  • FK506 Binding Protein 9 2 3 5
  • FK506 Binding Protein 9, 63 KDa 2 3
  • 63 KDa FK506-Binding Protein 3 4
  • FK506-Binding Protein 9 3 4
  • PPIase FKBP9 3 4
  • 63 KDa FKBP 3 4
  • EC 5.2.1.8 4 61
  • Rotamase 3 4
  • FKBP-63 3 4
  • FKBP-9 3 4
  • FKBP60 3 4
  • FKBP63 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase FKBP9 3
  • FK506-Binding Protein 9 (63 KD) 2
  • PPIASE 3

External Ids for FKBP9 Gene

Previous GeneCards Identifiers for FKBP9 Gene

  • GC07M055212
  • GC07M055456
  • GC07M055491
  • GC07P032739
  • GC07P032770
  • GC07P032963
  • GC07P032997
  • GC07P032875

Summaries for FKBP9 Gene

GeneCards Summary for FKBP9 Gene

FKBP9 (FK506 Binding Protein 9) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Chaperonin-mediated protein folding. GO annotations related to this gene include calcium ion binding and FK506 binding. An important paralog of this gene is FKBP10.

UniProtKB/Swiss-Prot for FKBP9 Gene

  • PPIases accelerate the folding of proteins during protein synthesis.

Gene Wiki entry for FKBP9 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBP9 Gene

Genomics for FKBP9 Gene

Regulatory Elements for FKBP9 Gene

Enhancers for FKBP9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around FKBP9 on UCSC Golden Path with GeneCards custom track

Promoters for FKBP9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FKBP9 on UCSC Golden Path with GeneCards custom track

Genomic Location for FKBP9 Gene

Chromosome:
7
Start:
32,957,404 bp from pter
End:
33,006,931 bp from pter
Size:
49,528 bases
Orientation:
Plus strand

Genomic View for FKBP9 Gene

Genes around FKBP9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FKBP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FKBP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP9 Gene

Proteins for FKBP9 Gene

  • Protein details for FKBP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95302-FKBP9_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP9
    Protein Accession:
    O95302
    Secondary Accessions:
    • B3KY35
    • B7Z1G9
    • B7Z6H3
    • Q2M2A1
    • Q3MIR7
    • Q6IN76
    • Q6P2N1
    • Q96EX5
    • Q96IJ9

    Protein attributes for FKBP9 Gene

    Size:
    570 amino acids
    Molecular mass:
    63084 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FKBP9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FKBP9 Gene

Selected DME Specific Peptides for FKBP9 Gene

Post-translational modifications for FKBP9 Gene

Other Protein References for FKBP9 Gene

Domains & Families for FKBP9 Gene

Protein Domains for FKBP9 Gene

Graphical View of Domain Structure for InterPro Entry

O95302

UniProtKB/Swiss-Prot:

FKBP9_HUMAN :
  • Contains 2 EF-hand domains.
Domain:
  • Contains 2 EF-hand domains.
  • Contains 4 PPIase FKBP-type domains.
genes like me logo Genes that share domains with FKBP9: view

Function for FKBP9 Gene

Molecular function for FKBP9 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by FK506.
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins during protein synthesis.

Enzyme Numbers (IUBMB) for FKBP9 Gene

Gene Ontology (GO) - Molecular Function for FKBP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0005509 calcium ion binding ISS --
GO:0005528 FK506 binding IBA --
genes like me logo Genes that share ontologies with FKBP9: view
genes like me logo Genes that share phenotypes with FKBP9: view

Animal Models for FKBP9 Gene

MGI Knock Outs for FKBP9:

Animal Model Products

  • Taconic Biosciences Mouse Models for FKBP9

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FKBP9 Gene

Localization for FKBP9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP9 Gene

Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FKBP9 Gene COMPARTMENTS Subcellular localization image for FKBP9 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 2
cytoskeleton 1
cytosol 1
extracellular 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FKBP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum ISS --
GO:0005789 endoplasmic reticulum membrane IBA --
genes like me logo Genes that share ontologies with FKBP9: view

Pathways & Interactions for FKBP9 Gene

genes like me logo Genes that share pathways with FKBP9: view

Gene Ontology (GO) - Biological Process for FKBP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0006457 protein folding ISS --
GO:0061077 chaperone-mediated protein folding IBA --
genes like me logo Genes that share ontologies with FKBP9: view

No data available for SIGNOR curated interactions for FKBP9 Gene

Drugs & Compounds for FKBP9 Gene

No Compound Related Data Available

Transcripts for FKBP9 Gene

Unigene Clusters for FKBP9 Gene

FK506 binding protein 9, 63 kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP9 Gene

No ASD Table

Relevant External Links for FKBP9 Gene

GeneLoc Exon Structure for
FKBP9
ECgene alternative splicing isoforms for
FKBP9

Expression for FKBP9 Gene

mRNA expression in normal human tissues for FKBP9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FKBP9 Gene

This gene is overexpressed in Bone marrow stromal cell (26.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FKBP9 Gene



Protein tissue co-expression partners for FKBP9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FKBP9 Gene:

FKBP9

SOURCE GeneReport for Unigene cluster for FKBP9 Gene:

Hs.103934
genes like me logo Genes that share expression patterns with FKBP9: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FKBP9 Gene

Orthologs for FKBP9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FKBP9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FKBP9 34
  • 91.59 (n)
  • 97 (a)
FKBP9 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FKBP9 34
  • 91.55 (n)
  • 97.01 (a)
FKBP9 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fkbp9 34
  • 87.91 (n)
  • 93.13 (a)
Fkbp9 16
Fkbp9 35
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FKBP9 34
  • 99.77 (n)
  • 99.82 (a)
FKBP9 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fkbp9 34
  • 88.44 (n)
  • 94.19 (a)
oppossum
(Monodelphis domestica)
Mammalia FKBP9 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FKBP9 35
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves FKBP9 34
  • 76.81 (n)
  • 81.42 (a)
FKBP9 35
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FKBP9 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fkbp9 34
  • 72.74 (n)
  • 78.64 (a)
Str.10967 34
zebrafish
(Danio rerio)
Actinopterygii fkbp9 34
  • 67.66 (n)
  • 68.6 (a)
fkbp9 35
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14715 35
  • 41 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea fkb-5 34
  • 47.42 (n)
  • 35.91 (a)
fkb-3 35
  • 33 (a)
ManyToMany
fkb-4 35
  • 31 (a)
ManyToMany
fkb-5 35
  • 31 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPR2 35
  • 39 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12333 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5986 35
  • 42 (a)
OneToMany
Species where no ortholog for FKBP9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FKBP9 Gene

ENSEMBL:
Gene Tree for FKBP9 (if available)
TreeFam:
Gene Tree for FKBP9 (if available)

Paralogs for FKBP9 Gene

Paralogs for FKBP9 Gene

Pseudogenes.org Pseudogenes for FKBP9 Gene

genes like me logo Genes that share paralogs with FKBP9: view

Variants for FKBP9 Gene

Sequence variations from dbSNP and Humsavar for FKBP9 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs7793408 -- 32,969,944(+) gcagt(A/G)agccg intron-variant
rs2392166 -- 32,964,633(+) TGCAG(C/T)GTTCT intron-variant
rs2392167 -- 32,967,356(+) acttt(A/G)tgccc intron-variant
rs2392168 -- 32,967,378(+) tctct(G/T)cattt intron-variant
rs2392169 -- 32,967,510(+) tttca(C/T)tttac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FKBP9 Gene

Variant ID Type Subtype PubMed ID
dgv1080e201 CNV deletion 23290073
esv27091 CNV gain+loss 19812545
esv2734229 CNV deletion 23290073
esv3612750 OTHER inversion 21293372
nsv1029220 CNV gain 25217958
nsv1033096 CNV loss 25217958
nsv1128310 CNV deletion 24896259
nsv1135982 CNV deletion 24896259
nsv436907 CNV insertion 17901297
nsv981447 CNV duplication 23825009

Variation tolerance for FKBP9 Gene

Residual Variation Intolerance Score: 73.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FKBP9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FKBP9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FKBP9 Gene

Disorders for FKBP9 Gene

Relevant External Links for FKBP9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FKBP9

No disorders were found for FKBP9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FKBP9 Gene

Publications for FKBP9 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  2. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PMID: 12754519) Zhang H. … Aebersold R. (Nat. Biotechnol. 2003) 3 4 65
  3. Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family. (PMID: 12036304) Patterson C.E. … Davis E.C. (Genomics 2002) 2 3 65
  4. Biochemical analysis of mouse FKBP60, a novel member of the FKBP family. (PMID: 10524204) Shadidy M. … Krauss S. (Biochim. Biophys. Acta 1999) 3 4 65
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65

Products for FKBP9 Gene

Sources for FKBP9 Gene

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