Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FKBP8 Gene

Aliases for FKBP8 Gene

  • FK506 Binding Protein 8 2 3 5
  • FK506-Binding Protein 8 (38kD) 2 2
  • FK506 Binding Protein 8, 38kDa 2 3
  • 38 KDa FK506-Binding Protein 3 4
  • PPIase FKBP8 3 4
  • 38 KDa FKBP 3 4
  • Rotamase 3 4
  • FKBPr38 3 4
  • FKBP-38 3 4
  • HFKBP38 3 4
  • FKBP-8 3 4
  • FKBP38 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase FKBP8 3
  • FK506-Binding Protein 8 4
  • EC 5.2.1.8 4

External Ids for FKBP8 Gene

Previous GeneCards Identifiers for FKBP8 Gene

  • GC19M019136
  • GC19M019034
  • GC19M018487
  • GC19M018642
  • GC19M018205

Summaries for FKBP8 Gene

Entrez Gene Summary for FKBP8 Gene

  • The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008]

GeneCards Summary for FKBP8 Gene

FKBP8 (FK506 Binding Protein 8) is a Protein Coding gene. Diseases associated with FKBP8 include Hepatitis C Virus. Among its related pathways are Metabolism of proteins and Deubiquitination. GO annotations related to this gene include identical protein binding and FK506 binding. An important paralog of this gene is FKBP4.

UniProtKB/Swiss-Prot for FKBP8 Gene

  • Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.

Gene Wiki entry for FKBP8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBP8 Gene

Genomics for FKBP8 Gene

Regulatory Elements for FKBP8 Gene

Enhancers for FKBP8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F018512 1.6 FANTOM5 ENCODE 14.2 +26.3 26267 10.5 HDGF PKNOX1 ARNT MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ELL SSBP4 FKBP8 ENSG00000268030 LRRC25 PGPEP1 IL12RB1 JUND KXD1 UPF1
GH19F018492 1.7 FANTOM5 Ensembl ENCODE 12.6 +42.7 42677 18.8 MLX ARID4B DMAP1 ZNF2 YY1 ZNF143 ZNF263 SP3 SP5 NFYC ELL SSBP4 FKBP8 UBA52 CRTC1 KXD1 C19orf60 ARRDC2 JUND IL12RB1
GH19F018086 1.5 FANTOM5 ENCODE 13.4 +454.8 454762 5.9 HDGF PKNOX1 ZFP64 ZNF493 ARID4B ZNF48 ZNF121 ZNF202 ZNF263 JUNB ENSG00000268030 UPF1 IL12RB1 FKBP8 ENSG00000268938 ELL ENSG00000269191 ENSG00000269815 FCHO1 LRRC25
GH19F018698 1.6 FANTOM5 Ensembl ENCODE 3.6 -156.1 -156124 3.2 HDGF ATF1 PKNOX1 FEZF1 ZNF2 GLIS2 GATA2 ZNF263 SP3 TSHZ1 ENSG00000268199 GMIP LPAR2 CRTC1 CRLF1 UBA52 FKBP8 SLC25A42 UPF1 JUND
GH19F018542 1.1 ENCODE 0.8 +0.8 812 3.0 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 SIN3A ARID4B YBX1 ZNF143 ZNF207 UBA52 SSBP4 FKBP8 PIR40896
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FKBP8 on UCSC Golden Path with GeneCards custom track

Promoters for FKBP8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000215688 877 2001 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 SIN3A ARID4B YBX1 ZNF143 ZNF207

Genomic Location for FKBP8 Gene

Chromosome:
19
Start:
18,531,751 bp from pter
End:
18,544,077 bp from pter
Size:
12,327 bases
Orientation:
Minus strand

Genomic View for FKBP8 Gene

Genes around FKBP8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FKBP8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FKBP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP8 Gene

Proteins for FKBP8 Gene

  • Protein details for FKBP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14318-FKBP8_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP8
    Protein Accession:
    Q14318
    Secondary Accessions:
    • C8C9T5
    • Q53GU3
    • Q7Z349
    • Q86YK6

    Protein attributes for FKBP8 Gene

    Size:
    412 amino acids
    Molecular mass:
    44562 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCL2L1/BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with HCV NS5A. Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation.
    Miscellaneous:
    • Binds the immunosuppressant FK506 only in its calmodulin/calcium activated form.
    SequenceCaution:
    • Sequence=AAB00102.1; Type=Miscellaneous discrepancy; Note=The first part of the cDNA maps to the same locus, but in opposite orientation.; Evidence={ECO:0000305}; Sequence=AAH09966.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD98028.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FKBP8 Gene

    Alternative splice isoforms for FKBP8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FKBP8 Gene

Post-translational modifications for FKBP8 Gene

  • Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
  • Ubiquitination at Lys 249, Lys 271, Lys 273, Lys 284, Lys 307, Lys 314, Lys 334, Lys 340, Lys 348, Lys 351, and Lys 352
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for FKBP8
  • Santa Cruz Biotechnology (SCBT) Antibodies for FKBP8

No data available for DME Specific Peptides for FKBP8 Gene

Domains & Families for FKBP8 Gene

Suggested Antigen Peptide Sequences for FKBP8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14318

UniProtKB/Swiss-Prot:

FKBP8_HUMAN :
  • Contains 1 PPIase FKBP-type domain.
  • Contains 3 TPR repeats.
Domain:
  • Contains 1 PPIase FKBP-type domain.
Similarity:
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with FKBP8: view

Function for FKBP8 Gene

Molecular function for FKBP8 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot Function:
Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.

Enzyme Numbers (IUBMB) for FKBP8 Gene

Gene Ontology (GO) - Molecular Function for FKBP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0005515 protein binding IPI 16844119
GO:0005528 FK506 binding IBA --
GO:0016853 isomerase activity IEA --
GO:0042802 identical protein binding IPI 17024179
genes like me logo Genes that share ontologies with FKBP8: view
genes like me logo Genes that share phenotypes with FKBP8: view

Animal Models for FKBP8 Gene

MGI Knock Outs for FKBP8:

Animal Model Products

miRNA for FKBP8 Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FKBP8

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FKBP8 Gene

Localization for FKBP8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP8 Gene

Mitochondrion. Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side.
Isoform 1: Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side.
Isoform 3: Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FKBP8 gene
Compartment Confidence
mitochondrion 5
endoplasmic reticulum 5
cytosol 5
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FKBP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005740 mitochondrial envelope IEA --
GO:0005789 endoplasmic reticulum membrane IBA --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FKBP8: view

Pathways & Interactions for FKBP8 Gene

genes like me logo Genes that share pathways with FKBP8: view

SIGNOR curated interactions for FKBP8 Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for FKBP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0001708 cell fate specification IEA --
GO:0006457 protein folding IEA --
GO:0006915 apoptotic process IEA --
GO:0007224 smoothened signaling pathway IEA --
genes like me logo Genes that share ontologies with FKBP8: view

Drugs & Compounds for FKBP8 Gene

(2) Drugs for FKBP8 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with FKBP8: view

Transcripts for FKBP8 Gene

Unigene Clusters for FKBP8 Gene

FK506 binding protein 8, 38kDa:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FKBP8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1:
SP2:
SP3: -

Relevant External Links for FKBP8 Gene

GeneLoc Exon Structure for
FKBP8
ECgene alternative splicing isoforms for
FKBP8

Expression for FKBP8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FKBP8 Gene

mRNA differential expression in normal tissues according to GTEx for FKBP8 Gene

This gene is overexpressed in Whole Blood (x14.9).

Protein differential expression in normal tissues from HIPED for FKBP8 Gene

This gene is overexpressed in Breast (53.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FKBP8 Gene



Protein tissue co-expression partners for FKBP8 Gene

NURSA nuclear receptor signaling pathways regulating expression of FKBP8 Gene:

FKBP8

SOURCE GeneReport for Unigene cluster for FKBP8 Gene:

Hs.173464

mRNA Expression by UniProt/SwissProt for FKBP8 Gene:

Q14318-FKBP8_HUMAN
Tissue specificity: Widely expressed. Highest levels seen in the brain. Highly abundant in the retina.
genes like me logo Genes that share expression patterns with FKBP8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FKBP8 Gene

Orthologs for FKBP8 Gene

This gene was present in the common ancestor of animals.

Orthologs for FKBP8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FKBP8 34 35
  • 99.6 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 92 (a)
OneToMany
FKBP8 34 35
  • 90.66 (n)
dog
(Canis familiaris)
Mammalia FKBP8 34 35
  • 89.64 (n)
mouse
(Mus musculus)
Mammalia Fkbp8 34 16 35
  • 86.68 (n)
rat
(Rattus norvegicus)
Mammalia Fkbp8 34
  • 86.19 (n)
oppossum
(Monodelphis domestica)
Mammalia FKBP8 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves FKBP8 34 35
  • 72.44 (n)
lizard
(Anolis carolinensis)
Reptilia FKBP8 35
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fkbp8 34
  • 62.49 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32522 34
zebrafish
(Danio rerio)
Actinopterygii fkbp8 34 35
  • 62.52 (n)
zgc77672 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13422 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006615 34
  • 49.62 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5482 36 34 35
  • 47.93 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
OneToOne
Species where no ortholog for FKBP8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FKBP8 Gene

ENSEMBL:
Gene Tree for FKBP8 (if available)
TreeFam:
Gene Tree for FKBP8 (if available)

Paralogs for FKBP8 Gene

Paralogs for FKBP8 Gene

Pseudogenes.org Pseudogenes for FKBP8 Gene

genes like me logo Genes that share paralogs with FKBP8: view

Variants for FKBP8 Gene

Sequence variations from dbSNP and Humsavar for FKBP8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10402554 -- 18,543,111(+) CACGC(C/T)CTCCT intron-variant, upstream-variant-2KB
rs10404975 -- 18,531,496(+) GAACG(C/T)TGGGG downstream-variant-500B
rs10410496 -- 18,537,588(+) CACCC(C/T)GGTGT intron-variant
rs10416685 -- 18,546,057(+) CTCAC(G/T)GAAAT upstream-variant-2KB
rs10417649 -- 18,545,225(+) ctaat(C/T)tgtat upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FKBP8 Gene

Variant ID Type Subtype PubMed ID
nsv1055794 CNV gain 25217958
nsv1061733 CNV gain 25217958
nsv1071921 CNV deletion 25765185
nsv833776 CNV loss 17160897
nsv952421 CNV deletion 24416366

Variation tolerance for FKBP8 Gene

Residual Variation Intolerance Score: 15.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.78; 58.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FKBP8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FKBP8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FKBP8 Gene

Disorders for FKBP8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FKBP8 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hepatitis c virus
  • hepatitic c virus
- elite association - COSMIC cancer census association via MalaCards
Search FKBP8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FKBP8

Genetic Association Database (GAD)
FKBP8
Human Genome Epidemiology (HuGE) Navigator
FKBP8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FKBP8
genes like me logo Genes that share disorders with FKBP8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FKBP8 Gene

Publications for FKBP8 Gene

  1. Isolation of a cDNA encoding a novel human FK506-binding protein homolog containing leucine zipper and tetratricopeptide repeat motifs. (PMID: 7543869) Lam E. … Wiederrecht G. (Gene 1995) 2 3 4 22 64
  2. Characterization of a Bcl-XL-interacting protein FKBP8 and its splice variant in human RPE cells. (PMID: 18385096) Chen Y. … Cai J. (Invest. Ophthalmol. Vis. Sci. 2008) 3 4 22 64
  3. Bcl-2 regulator FKBP38 is activated by Ca2+/calmodulin. (PMID: 15990872) Edlich F. … Fischer G. (EMBO J. 2005) 3 4 22 64
  4. Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis. (PMID: 12510191) Shirane M. … Nakayama K.I. (Nat. Cell Biol. 2003) 3 4 22 64
  5. A charge-sensitive loop in the FKBP38 catalytic domain modulates Bcl-2 binding. (PMID: 20140889) Maestre-MartA-nez M. … LA1cke C. (J. Mol. Recognit. 2011) 3 4 64

Products for FKBP8 Gene

Sources for FKBP8 Gene

Content
Loading form....