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Aliases for FKBP8 Gene

Aliases for FKBP8 Gene

  • FK506 Binding Protein 8, 38kDa 2 3
  • FK506-Binding Protein 8 (38kD) 2 2 3
  • FKBP38 3 4 6
  • 38 KDa FK506-Binding Protein 3 4
  • PPIase FKBP8 3 4
  • 38 KDa FKBP 3 4
  • Rotamase 3 4
  • FKBPr38 3 4
  • FKBP-38 3 4
  • HFKBP38 3 4
  • FKBP-8 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase FKBP8 3
  • FK506-Binding Protein 8 4
  • EC 5.2.1.8 4

External Ids for FKBP8 Gene

Summaries for FKBP8 Gene

Entrez Gene Summary for FKBP8 Gene

  • The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008]

GeneCards Summary for FKBP8 Gene

FKBP8 (FK506 Binding Protein 8, 38kDa) is a Protein Coding gene. Among its related pathways are Senescence and Autophagy and Role of Calcineurin-dependent NFAT signaling in lymphocytes. GO annotations related to this gene include identical protein binding and FK506 binding. An important paralog of this gene is FKBP1A.

UniProtKB/Swiss-Prot for FKBP8 Gene

  • Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.

Gene Wiki entry for FKBP8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBP8 Gene

Genomics for FKBP8 Gene

Genomic Location for FKBP8 Gene

Start:
18,531,751 bp from pter
End:
18,544,077 bp from pter
Size:
12,327 bases
Orientation:
Minus strand

Genomic View for FKBP8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FKBP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP8 Gene

Regulatory Elements for FKBP8 Gene

Proteins for FKBP8 Gene

  • Protein details for FKBP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14318-FKBP8_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP8
    Protein Accession:
    Q14318
    Secondary Accessions:
    • C8C9T5
    • Q53GU3
    • Q7Z349
    • Q86YK6

    Protein attributes for FKBP8 Gene

    Size:
    412 amino acids
    Molecular mass:
    44562 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCL2L1/BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with HCV NS5A. Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation.
    Miscellaneous:
    • Binds the immunosuppressant FK506 only in its calmodulin/calcium activated form
    SequenceCaution:
    • Sequence=AAB00102.1; Type=Miscellaneous discrepancy; Note=The first part of the cDNA maps to the same locus, but in opposite orientation.; Evidence={ECO:0000305}; Sequence=AAH09966.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD98028.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FKBP8 Gene

    Alternative splice isoforms for FKBP8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FKBP8 Gene

Proteomics data for FKBP8 Gene at MOPED

Post-translational modifications for FKBP8 Gene

  • Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys271 and Lys314

No data available for DME Specific Peptides for FKBP8 Gene

Domains for FKBP8 Gene

Gene Families for FKBP8 Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

UniProtKB/Swiss-Prot:

FKBP8_HUMAN
Domain:
  • Contains 1 PPIase FKBP-type domain.:
    • Q14318
Similarity:
  • Contains 3 TPR repeats.:
    • Q14318
genes like me logo Genes that share domains with FKBP8: view

Function for FKBP8 Gene

Molecular function for FKBP8 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot Function: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.

Enzyme Numbers (IUBMB) for FKBP8 Gene

Gene Ontology (GO) - Molecular Function for FKBP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0005515 protein binding IPI 16844119
GO:0005528 FK506 binding IBA --
GO:0042802 identical protein binding IPI 17024179
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FKBP8: view
genes like me logo Genes that share phenotypes with FKBP8: view

Animal Models for FKBP8 Gene

MGI Knock Outs for FKBP8:

miRNA for FKBP8 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for FKBP8 Gene

Localization for FKBP8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP8 Gene

Isoform 1: Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side.
Isoform 3: Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FKBP8 Gene COMPARTMENTS Subcellular localization image for FKBP8 gene
Compartment Confidence
mitochondrion 5
endoplasmic reticulum 3
cytosol 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FKBP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005740 mitochondrial envelope --
GO:0005789 endoplasmic reticulum membrane IBA --
GO:0016020 membrane IDA 19946888
GO:0030176 integral component of endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with FKBP8: view

Pathways for FKBP8 Gene

genes like me logo Genes that share pathways with FKBP8: view

Pathways by source for FKBP8 Gene

Gene Ontology (GO) - Biological Process for FKBP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IBA --
GO:0001708 cell fate specification IEA --
GO:0006457 protein folding --
GO:0006915 apoptotic process IEA --
GO:0007224 smoothened signaling pathway IEA --
genes like me logo Genes that share ontologies with FKBP8: view

Compounds for FKBP8 Gene

(1) HMDB Compounds for FKBP8 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Novoseek inferred chemical compound relationships for FKBP8 Gene

Compound -log(P) Hits PubMed IDs
tacrolimus 47.1 4
genes like me logo Genes that share compounds with FKBP8: view

Transcripts for FKBP8 Gene

Unigene Clusters for FKBP8 Gene

FK506 binding protein 8, 38kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1:
SP2:
SP3: -

Relevant External Links for FKBP8 Gene

GeneLoc Exon Structure for
FKBP8
ECgene alternative splicing isoforms for
FKBP8

Expression for FKBP8 Gene

mRNA expression in normal human tissues for FKBP8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FKBP8 Gene

This gene is overexpressed in Whole Blood (14.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FKBP8 Gene

SOURCE GeneReport for Unigene cluster for FKBP8 Gene Hs.173464

mRNA Expression by UniProt/SwissProt for FKBP8 Gene

Q14318-FKBP8_HUMAN
Tissue specificity: Widely expressed. Highest levels seen in the brain. Highly abundant in the retina.
genes like me logo Genes that share expressions with FKBP8: view

Orthologs for FKBP8 Gene

This gene was present in the common ancestor of animals.

Orthologs for FKBP8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FKBP8 36
  • 99.6 (n)
  • 99.76 (a)
FKBP8 37
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 92 (a)
OneToMany
FKBP8 36
  • 90.66 (n)
  • 96.56 (a)
FKBP8 37
  • 96 (a)
OneToMany
dog
(Canis familiaris)
Mammalia FKBP8 36
  • 89.64 (n)
  • 97.09 (a)
FKBP8 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fkbp8 36
  • 86.68 (n)
  • 92.31 (a)
Fkbp8 16
Fkbp8 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FKBP8 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fkbp8 36
  • 86.19 (n)
  • 92.8 (a)
chicken
(Gallus gallus)
Aves FKBP8 36
  • 72.44 (n)
  • 72 (a)
FKBP8 37
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FKBP8 37
  • 47 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32522 36
tropical clawed frog
(Silurana tropicalis)
Amphibia fkbp8 36
  • 62.49 (n)
  • 62.4 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13422 36
zebrafish
(Danio rerio)
Actinopterygii fkbp8 36
  • 62.52 (n)
  • 63.87 (a)
fkbp8 37
  • 57 (a)
OneToOne
zgc77672 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006615 36
  • 49.62 (n)
  • 37.94 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5482 36
  • 47.93 (n)
  • 35.62 (a)
CG5482 37
  • 30 (a)
OneToOne
CG5482 38
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 37 (a)
OneToOne
Species with no ortholog for FKBP8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FKBP8 Gene

ENSEMBL:
Gene Tree for FKBP8 (if available)
TreeFam:
Gene Tree for FKBP8 (if available)

Paralogs for FKBP8 Gene

Paralogs for FKBP8 Gene

Pseudogenes.org Pseudogenes for FKBP8 Gene

genes like me logo Genes that share paralogs with FKBP8: view

Variants for FKBP8 Gene

Sequence variations from dbSNP and Humsavar for FKBP8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1058799 -- 18,532,075(-) CTGGT(C/T)TGGCC utr-variant-3-prime
rs1058849 -- 18,531,922(-) CTGGG(C/G)TAGGT utr-variant-3-prime
rs1058853 -- 18,531,892(-) AGTTT(C/T)TCCTC utr-variant-3-prime
rs1803588 -- 18,531,910(-) TCCGC(C/T)AGGGC utr-variant-3-prime
rs2314668 -- 18,538,357(-) ACCTG(C/G)AGATG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for FKBP8 Gene

Variant ID Type Subtype PubMed ID
nsv911274 CNV Loss 21882294
nsv911281 CNV Loss 21882294
nsv911282 CNV Loss 21882294
nsv911283 CNV Loss 21882294
nsv833776 CNV Loss 17160897
nsv911284 CNV Loss 21882294
nsv911285 CNV Loss 21882294
dgv3784n71 CNV Loss 21882294

Relevant External Links for FKBP8 Gene

HapMap Linkage Disequilibrium report
FKBP8

Disorders for FKBP8 Gene

(1) University of Copenhagen DISEASES for FKBP8 Gene

Relevant External Links for FKBP8

Genetic Association Database (GAD)
FKBP8
Human Genome Epidemiology (HuGE) Navigator
FKBP8
genes like me logo Genes that share disorders with FKBP8: view

No data available for UniProtKB/Swiss-Prot for FKBP8 Gene

Publications for FKBP8 Gene

  1. Isolation of a cDNA encoding a novel human FK506-binding protein homolog containing leucine zipper and tetratricopeptide repeat motifs. (PMID: 7543869) Lam E. … Wiederrecht G. (Gene 1995) 2 3 4 23
  2. Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis. (PMID: 12510191) Shirane M. … Nakayama K.I. (Nat. Cell Biol. 2003) 3 4 23
  3. Bcl-2 regulator FKBP38 is activated by Ca2+/calmodulin. (PMID: 15990872) Edlich F. … Fischer G. (EMBO J. 2005) 3 4 23
  4. Characterization of a Bcl-XL-interacting protein FKBP8 and its splice variant in human RPE cells. (PMID: 18385096) Chen Y. … Cai J. (Invest. Ophthalmol. Vis. Sci. 2008) 3 4 23
  5. Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90. (PMID: 17024179) Okamoto T. … Matsuura Y. (EMBO J. 2006) 3 23

Products for FKBP8 Gene

  • Addgene plasmids for FKBP8

Sources for FKBP8 Gene

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