Aliases for FKBP8 Gene
External Ids for FKBP8 Gene
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008]
GeneCards Summary for FKBP8 Gene
FKBP8 (FK506 Binding Protein 8, 38kDa) is a Protein Coding gene. Among its related pathways are Senescence and Autophagy and Role of Calcineurin-dependent NFAT signaling in lymphocytes. GO annotations related to this gene include identical protein binding and FK506 binding. An important paralog of this gene is FKBP1A.
UniProtKB/Swiss-Prot for FKBP8 Gene
Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.