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Aliases for FKBP7 Gene

Aliases for FKBP7 Gene

  • FK506 Binding Protein 7 2 3 5
  • 23 KDa FK506-Binding Protein 3 4
  • FK506-Binding Protein 7 2 4
  • PPIase FKBP7 3 4
  • 23 KDa FKBP 3 4
  • Rotamase 3 4
  • FKBP-23 3 4
  • FKBP-7 3 4
  • FKBP23 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase FKBP7 3
  • FK506-Binding Protein 23 3
  • EC 4
  • PPIASE 3

External Ids for FKBP7 Gene

Previous GeneCards Identifiers for FKBP7 Gene

  • GC02M177392
  • GC02M178001
  • GC02M179294
  • GC02M179532
  • GC02M179155
  • GC02M179038
  • GC02M179328
  • GC02M171200

Summaries for FKBP7 Gene

Entrez Gene Summary for FKBP7 Gene

  • The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. Members of this family exhibit PPIase activity and function as molecular chaperones. A similar protein in mouse is located in the endoplasmic reticulum and binds calcium. [provided by RefSeq, Jul 2008]

GeneCards Summary for FKBP7 Gene

FKBP7 (FK506 Binding Protein 7) is a Protein Coding gene. Diseases associated with FKBP7 include Osteogenesis Imperfecta, Type Ix. GO annotations related to this gene include calcium ion binding and FK506 binding. An important paralog of this gene is FKBP14.

UniProtKB/Swiss-Prot for FKBP7 Gene

  • PPIases accelerate the folding of proteins during protein synthesis.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBP7 Gene

Genomics for FKBP7 Gene

Regulatory Elements for FKBP7 Gene

Enhancers for FKBP7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G178448 1.4 Ensembl ENCODE 32.2 +29.6 29571 3.7 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX CREB3L1 ARNT ZFP64 ARID4B SIN3A FKBP7 PLEKHA3 ENSG00000270574 ENSG00000237477 LOC101927027 DFNB59 PRKRA
GH02G178412 1.2 ENCODE 23.6 +66.2 66150 2.7 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC FKBP7 PLEKHA3 DFNB59 PRKRA LOC101927027
GH02G178428 1 ENCODE 17.2 +51.9 51867 1.0 FOXA2 ATF1 ARID4B DMAP1 GATA2 MIER2 ZNF592 KAT8 CREB3 MIER3 FKBP7 DFNB59 PRKRA LOC101927027
GH02G178484 0.9 Ensembl 16.8 -4.3 -4314 0.6 NFIB INSM2 FEZF1 ZNF366 ZSCAN5C ZNF350 ZNF391 ZNF263 ZNF174 TSHZ1 LOC101927027 FKBP7 DFNB59 PRKRA ENSG00000271401 PLEKHA3 TTN-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FKBP7 on UCSC Golden Path with GeneCards custom track

Promoters for FKBP7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000126975 -407 1601 HNRNPUL1 FOXA2 CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 SP3

Genomic Location for FKBP7 Gene

178,463,664 bp from pter
178,480,393 bp from pter
16,730 bases
Minus strand

Genomic View for FKBP7 Gene

Genes around FKBP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FKBP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FKBP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP7 Gene

Proteins for FKBP7 Gene

  • Protein details for FKBP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP7
    Protein Accession:
    Secondary Accessions:
    • Q4ZG70
    • Q6V3B2
    • Q86U65
    • Q96DA4
    • Q9Y6B0

    Protein attributes for FKBP7 Gene

    259 amino acids
    Molecular mass:
    30009 Da
    Quaternary structure:
    No Data Available
    • Binds calcium.

    Alternative splice isoforms for FKBP7 Gene


neXtProt entry for FKBP7 Gene

Post-translational modifications for FKBP7 Gene

No data available for DME Specific Peptides for FKBP7 Gene

Domains & Families for FKBP7 Gene

Protein Domains for FKBP7 Gene

Suggested Antigen Peptide Sequences for FKBP7 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FKBP7: view

No data available for UniProtKB/Swiss-Prot for FKBP7 Gene

Function for FKBP7 Gene

Molecular function for FKBP7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins during protein synthesis.

Enzyme Numbers (IUBMB) for FKBP7 Gene

Gene Ontology (GO) - Molecular Function for FKBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA,IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 15846844
GO:0005528 FK506 binding IBA --
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with FKBP7: view

Phenotypes for FKBP7 Gene

genes like me logo Genes that share phenotypes with FKBP7: view

Animal Model Products

CRISPR Products

miRNA for FKBP7 Gene

miRTarBase miRNAs that target FKBP7

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FKBP7 Gene

Localization for FKBP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP7 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FKBP7 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FKBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005788 endoplasmic reticulum lumen IEA --
genes like me logo Genes that share ontologies with FKBP7: view

Pathways & Interactions for FKBP7 Gene

SuperPathways for FKBP7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FKBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0061077 chaperone-mediated protein folding IBA --
genes like me logo Genes that share ontologies with FKBP7: view

No data available for Pathways by source and SIGNOR curated interactions for FKBP7 Gene

Drugs & Compounds for FKBP7 Gene

(1) Drugs for FKBP7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with FKBP7: view

Transcripts for FKBP7 Gene

Unigene Clusters for FKBP7 Gene

FK506 binding protein 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP7 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: -
SP2: - -
SP3: - -
SP4: - -
SP5: - -
SP7: - - -
SP8: - -

Relevant External Links for FKBP7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FKBP7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FKBP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FKBP7 Gene

This gene is overexpressed in Bone marrow stromal cell (9.9), Uterus (9.7), Heart (7.7), and Ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FKBP7 Gene

Protein tissue co-expression partners for FKBP7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FKBP7 Gene:


SOURCE GeneReport for Unigene cluster for FKBP7 Gene:


Evidence on tissue expression from TISSUES for FKBP7 Gene

  • Lung(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with FKBP7: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FKBP7 Gene

Orthologs for FKBP7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FKBP7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FKBP7 34 35
  • 99.7 (n)
(Bos Taurus)
Mammalia FKBP7 34 35
  • 90.83 (n)
(Canis familiaris)
Mammalia FKBP7 34 35
  • 90.37 (n)
(Rattus norvegicus)
Mammalia Fkbp7 34
  • 85.47 (n)
(Mus musculus)
Mammalia Fkbp7 34 16 35
  • 85.02 (n)
(Monodelphis domestica)
Mammalia FKBP7 35
  • 79 (a)
(Gallus gallus)
Aves FKBP7 34 35
  • 71.72 (n)
(Anolis carolinensis)
Reptilia FKBP7 35
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fkbp7 34
  • 68.53 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2913 34
(Danio rerio)
Actinopterygii fkbp7 34 35
  • 61.57 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10818 34
fruit fly
(Drosophila melanogaster)
Insecta Fkbp13 36 35
  • 41 (a)
(Caenorhabditis elegans)
Secernentea fkb-7 35
  • 17 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPR2 35
  • 38 (a)
Species where no ortholog for FKBP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FKBP7 Gene

Gene Tree for FKBP7 (if available)
Gene Tree for FKBP7 (if available)

Paralogs for FKBP7 Gene

Paralogs for FKBP7 Gene Pseudogenes for FKBP7 Gene

genes like me logo Genes that share paralogs with FKBP7: view

Variants for FKBP7 Gene

Sequence variations from dbSNP and Humsavar for FKBP7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000025434 -- 178,468,864(+) CTATT(A/G)TTATC intron-variant
rs1000271469 -- 178,473,178(+) TTAAT(-/AAC)AACTT intron-variant
rs1000955904 -- 178,477,626(+) TCTAA(A/T)GATAT intron-variant
rs1001072054 -- 178,477,876(+) AACCT(A/G)TAAAA intron-variant
rs1001167856 -- 178,478,674(+) GCGGG(A/C)TCAGC upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FKBP7 Gene

Variant ID Type Subtype PubMed ID
nsv471944 CNV novel sequence insertion 20440878
nsv834467 CNV loss 17160897

Variation tolerance for FKBP7 Gene

Residual Variation Intolerance Score: 25.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FKBP7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FKBP7 Gene

Disorders for FKBP7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FKBP7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
osteogenesis imperfecta, type ix
  • osteogenesis imperfecta type 9
- elite association - COSMIC cancer census association via MalaCards
Search FKBP7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FKBP7

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FKBP7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FKBP7 Gene

Publications for FKBP7 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  3. Molecular cloning, characterization, and chromosomal localization of FKBP23, a novel FK506-binding protein with Ca2+-binding ability. (PMID: 9806833) Nakamura T. … Honjo T. (Genomics 1998) 2 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for FKBP7 Gene

Sources for FKBP7 Gene

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