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Aliases for FKBP7 Gene

Aliases for FKBP7 Gene

  • FK506 Binding Protein 7 2 3 5
  • FK506-Binding Protein 7 2 3 4
  • 23 KDa FK506-Binding Protein 3 4
  • PPIase FKBP7 3 4
  • 23 KDa FKBP 3 4
  • Rotamase 3 4
  • FKBP-23 3 4
  • FKBP-7 3 4
  • FKBP23 3 4
  • FK506-Binding Protein 23 3
  • EC 5.2.1.8 4
  • PPIASE 3

External Ids for FKBP7 Gene

Previous GeneCards Identifiers for FKBP7 Gene

  • GC02M177392
  • GC02M178001
  • GC02M179294
  • GC02M179532
  • GC02M179155
  • GC02M179038
  • GC02M179328
  • GC02M171200

Summaries for FKBP7 Gene

Entrez Gene Summary for FKBP7 Gene

  • The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. Members of this family exhibit PPIase activity and function as molecular chaperones. A similar protein in mouse is located in the endoplasmic reticulum and binds calcium. [provided by RefSeq, Jul 2008]

GeneCards Summary for FKBP7 Gene

FKBP7 (FK506 Binding Protein 7) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and FK506 binding. An important paralog of this gene is FKBP10.

UniProtKB/Swiss-Prot for FKBP7 Gene

  • PPIases accelerate the folding of proteins during protein synthesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBP7 Gene

Genomics for FKBP7 Gene

Regulatory Elements for FKBP7 Gene

Enhancers for FKBP7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FKBP7 on UCSC Golden Path with GeneCards custom track

Genomic Location for FKBP7 Gene

Chromosome:
2
Start:
178,463,664 bp from pter
End:
178,480,393 bp from pter
Size:
16,730 bases
Orientation:
Minus strand

Genomic View for FKBP7 Gene

Genes around FKBP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FKBP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FKBP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP7 Gene

Proteins for FKBP7 Gene

  • Protein details for FKBP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y680-FKBP7_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP7
    Protein Accession:
    Q9Y680
    Secondary Accessions:
    • Q4ZG70
    • Q6V3B2
    • Q86U65
    • Q96DA4
    • Q9Y6B0

    Protein attributes for FKBP7 Gene

    Size:
    259 amino acids
    Molecular mass:
    30009 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Binds calcium.

    Alternative splice isoforms for FKBP7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FKBP7 Gene

Proteomics data for FKBP7 Gene at MOPED

Post-translational modifications for FKBP7 Gene

Other Protein References for FKBP7 Gene

Antibody Products

  • Abcam antibodies for FKBP7
  • Santa Cruz Biotechnology (SCBT) Antibodies for FKBP7

No data available for DME Specific Peptides for FKBP7 Gene

Domains & Families for FKBP7 Gene

Protein Domains for FKBP7 Gene

Suggested Antigen Peptide Sequences for FKBP7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y680

UniProtKB/Swiss-Prot:

FKBP7_HUMAN :
  • Contains 2 EF-hand domains.
Domain:
  • Contains 2 EF-hand domains.
  • Contains 1 PPIase FKBP-type domain.
genes like me logo Genes that share domains with FKBP7: view

Function for FKBP7 Gene

Molecular function for FKBP7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins during protein synthesis.

Enzyme Numbers (IUBMB) for FKBP7 Gene

Gene Ontology (GO) - Molecular Function for FKBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15846844
genes like me logo Genes that share ontologies with FKBP7: view

Phenotypes for FKBP7 Gene

genes like me logo Genes that share phenotypes with FKBP7: view

Animal Model Products

miRNA for FKBP7 Gene

miRTarBase miRNAs that target FKBP7

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FKBP7 Gene

Localization for FKBP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP7 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FKBP7 Gene COMPARTMENTS Subcellular localization image for FKBP7 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FKBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IBA --
genes like me logo Genes that share ontologies with FKBP7: view

Pathways & Interactions for FKBP7 Gene

SuperPathways for FKBP7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FKBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0061077 chaperone-mediated protein folding IBA --
genes like me logo Genes that share ontologies with FKBP7: view

No data available for Pathways by source and SIGNOR curated interactions for FKBP7 Gene

Drugs & Compounds for FKBP7 Gene

(1) Drugs for FKBP7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with FKBP7: view

Transcripts for FKBP7 Gene

Unigene Clusters for FKBP7 Gene

FK506 binding protein 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP7 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: -
SP2: - -
SP3: - -
SP4: - -
SP5: - -
SP6:
SP7: - - -
SP8: - -

Relevant External Links for FKBP7 Gene

GeneLoc Exon Structure for
FKBP7
ECgene alternative splicing isoforms for
FKBP7

Expression for FKBP7 Gene

mRNA expression in normal human tissues for FKBP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FKBP7 Gene

This gene is overexpressed in Bone marrow stromal cell (9.9), Uterus (9.7), Heart (7.7), and Ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FKBP7 Gene



SOURCE GeneReport for Unigene cluster for FKBP7 Gene Hs.410378

genes like me logo Genes that share expression patterns with FKBP7: view

Protein tissue co-expression partners for FKBP7 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FKBP7 Gene

Orthologs for FKBP7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FKBP7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FKBP7 35
  • 90.83 (n)
  • 89.45 (a)
FKBP7 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FKBP7 35
  • 90.37 (n)
  • 89.45 (a)
FKBP7 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fkbp7 35
  • 85.02 (n)
  • 87.16 (a)
Fkbp7 16
Fkbp7 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FKBP7 35
  • 99.7 (n)
  • 99.55 (a)
FKBP7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fkbp7 35
  • 85.47 (n)
  • 87.61 (a)
oppossum
(Monodelphis domestica)
Mammalia FKBP7 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves FKBP7 35
  • 71.72 (n)
  • 72.51 (a)
FKBP7 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FKBP7 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fkbp7 35
  • 68.53 (n)
  • 65.58 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2913 35
zebrafish
(Danio rerio)
Actinopterygii fkbp7 35
  • 61.57 (n)
  • 58.8 (a)
fkbp7 36
  • 47 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10818 35
fruit fly
(Drosophila melanogaster)
Insecta Fkbp13 37
  • 41 (a)
Fkbp13 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea fkb-7 36
  • 17 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPR2 36
  • 38 (a)
OneToMany
Species with no ortholog for FKBP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FKBP7 Gene

ENSEMBL:
Gene Tree for FKBP7 (if available)
TreeFam:
Gene Tree for FKBP7 (if available)

Paralogs for FKBP7 Gene

Paralogs for FKBP7 Gene

Pseudogenes.org Pseudogenes for FKBP7 Gene

genes like me logo Genes that share paralogs with FKBP7: view

Variants for FKBP7 Gene

Sequence variations from dbSNP and Humsavar for FKBP7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1559908 -- 178,471,620(+) tgtca(C/T)cagta intron-variant
rs1863670 -- 178,463,417(+) CACAG(C/T)GGGAG downstream-variant-500B
rs1863671 -- 178,477,603(+) AATGG(C/T)ATATT intron-variant
rs4894023 -- 178,466,795(+) ccttt(G/T)gaaag intron-variant
rs1057164 -- 178,478,168(+) AACTT(C/T)TACCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FKBP7 Gene

Variant ID Type Subtype PubMed ID
nsv834467 CNV Loss 17160897

Variation tolerance for FKBP7 Gene

Residual Variation Intolerance Score: 25.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.96% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FKBP7 Gene

Disorders for FKBP7 Gene

Relevant External Links for FKBP7

Genetic Association Database (GAD)
FKBP7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FKBP7

No disorders were found for FKBP7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FKBP7 Gene

Publications for FKBP7 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Molecular cloning, characterization, and chromosomal localization of FKBP23, a novel FK506-binding protein with Ca2+-binding ability. (PMID: 9806833) Nakamura T. … Honjo T. (Genomics 1998) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for FKBP7 Gene

Sources for FKBP7 Gene

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