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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FKBP7 Gene

protein-coding GIFtS: 48
GCID: GC02M179328

FK506 binding protein 7

(Previous name: FK506-binding protein 7 )

Search for FKBP7
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
FK506 Binding Protein 7¹ ²		PPIase FKBP7² ³
FKBP23¹ ² ³		PPIase²
FK506-Binding Protein 7¹ ² ³		FK506-Binding Protein 23²
23 KDa FK506-Binding Protein² ³		Peptidyl-Prolyl Cis-Trans Isomerase FKBP7²
23 KDa FKBP² ³		Rotamase³
FKBP-23² ³		EC 5.2.1.8³
FKBP-7² ³		Rotamase³

External Ids:	HGNC: 3723¹	Entrez Gene: 51661²	Ensembl: ENSG00000079150⁷	OMIM: 607062⁵	UniProtKB: Q9Y680³

Export aliases for FKBP7 gene to outside databases

Previous GC identifers: GC02M177392 GC02M178001 GC02M179294 GC02M179532 GC02M179155 GC02M179038 GC02M171200

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FKBP7:

The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. Members

of this family exhibit PPIase activity and function as molecular chaperones. A similar protein in mouse is located in

the endoplasmic reticulum and binds calcium. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FKBP7_HUMAN, Q9Y680

Function: PPIases accelerate the folding of proteins during protein synthesis

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FKBP7 gene promoter:
AhR Pax-5 HNF-4alpha1 GATA-1 Arnt N-Myc POU2F1 POU2F1a IRF-7A ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FKBP7 promoter sequence

Search SABiosciences Chromatin IP Primers for FKBP7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FKBP7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.2 Ensembl cytogenetic band: 2q31.2 HGNC cytogenetic band: 2q31.2

FKBP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FKBP7 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M179328: view genomic region (about GC identifiers)

Start:	179,328,391 bp from pter	End:	179,343,355 bp from pter
Size:	14,965 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FKBP7_HUMAN, Q9Y680 (See protein sequence)

Recommended Name: Peptidyl-prolyl cis-trans isomerase FKBP7 precursor

Size: 259 amino acids; 30009 Da

Subcellular location: Endoplasmic reticulum lumen (By similarity)

Miscellaneous: Binds calcium (By similarity)

Secondary accessions: Q4ZG70 Q6V3B2 Q86U65 Q96DA4 Q9Y6B0

Alternative splicing: 3 isoforms: Q9Y680-1 Q9Y680-2 Q9Y680-3

Explore the universe of human proteins at neXtProt for FKBP7: NX_Q9Y680

Post-translational modifications:

Glycosylated (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y680

FKBP7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001128684.1 NP_851939.1

ENSEMBL proteins:

ENSP00000413152 ENSP00000233092 ENSP00000403801 ENSP00000398869 ENSP00000415486

ENSP00000389914

Human Recombinant Protein Products for FKBP7:

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	Uscn Proteins for FKBP7

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IDA	--
GO:0005788	endoplasmic reticulum lumen	IEA	--
GO:0016020	membrane	IBA	--

FKBP7 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FKBP7 for domains About GeneDecksing

5 InterPro domains/families:

IPR011992 EF-hand-like_dom

IPR002048 EF_hand_Ca-bd

IPR023566 PPIase_FKBP

IPR018247 EF_Hand_1_Ca_BS

IPR001179 PPIase_FKBP_dom

Graphical View of Domain Structure for InterPro Entry Q9Y680

ProtoNet protein and cluster: Q9Y680

UniProtKB/Swiss-Prot: FKBP7_HUMAN, Q9Y680

Similarity: Contains 2 EF-hand domains

Similarity: Contains 1 PPIase FKBP-type domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: FKBP7_HUMAN, Q9Y680

Function: PPIases accelerate the folding of proteins during protein synthesis

Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)

Enzyme Number (IUBMB): EC 5.2.1.8¹

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	IBA	--
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	--	--
GO:0005528	FK506 binding	IBA	--

FKBP7 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FKBP7

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		SwitchGear 3'UTR luciferase reporter plasmid: FKBP7 3' UTR sequence

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In Situ Assay
Products:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FKBP7

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

4 Interacting proteins for FKBP7 (Q9Y680³ ENSP00000413152⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBQLN4	Q9NRR5³, ENSP00000357292⁴	I2D: score=1 STRING: ENSP00000357292
POU5F1	Q01860³	I2D: score=1
IRF2	ENSP00000377218⁴	STRING: ENSP00000377218
--	ENSP00000405041⁴	STRING: ENSP00000405041

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000413	protein peptidyl-prolyl isomerization	IBA	--
GO:0006457	protein folding	IEA	--
GO:0018208	peptidyl-proline modification	IBA	--

FKBP7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FKBP7

1 HMDB Compound for FKBP7 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

Search CenterWatch for drugs/clinical trials and news about FKBP7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FKBP7 gene (3 alternative transcripts):

NM_001135212.1 NM_181342.2 NM_016105.2

Unigene Cluster for FKBP7:

FK506 binding protein 7

Hs.410378 [show with all ESTs]

Unigene Representative Sequence: NM_181342

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000424785(uc002umm.3 uc002umk.3 uc002uml.3 uc010zff.2)

ENST00000464248 ENST00000233092 ENST00000435079 ENST00000470945 ENST00000419184

ENST00000434643 ENST00000412612

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		hsa-miR-3149 hsa-miR-548k hsa-miR-890 hsa-miR-9 hsa-miR-144 hsa-miR-23a hsa-miR-450b-5p hsa-miR-203

		SwitchGear 3'UTR luciferase reporter plasmid: FKBP7 3' UTR sequence

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Additional cDNA sequence:

AF092137.1 AF100751.1 AK292145.1 AK299215.1 AY353086.1 AY359015.1 BC009711.1 BT007122.1

9 DOTS entries:

DT.421695 DT.95265949 DT.100755435 DT.121003309 DT.210199 DT.91678038 DT.99956927 DT.100637870

DT.100755434

24/71 AceView cDNA sequences (see all 71):

BU622441 CA843690 BC009711 AI879695 NM_181342 AI376847 BT007122 BG654869

AA425946 BG942178 AY359015 BG939266 AI753504 AY353086 BG654671 CB989909

AI277144 CA412939 AL709203 AA683602 BE874396 CA843439 AA548778 AI276877

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for FKBP7 (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c	·	6d	·	6e	·	6f
SP1:																	-
SP2:													-				-
SP3:													-				-
SP4:											-						-
SP5:											-						-

ECgene alternative splicing isoforms for FKBP7

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FKBP7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGGTGATGG

About this image

FKBP7 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

See FKBP7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FKBP7

SOURCE GeneReport for Unigene cluster: Hs.410378

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for FKBP7 gene from 7/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FKBP7¹	FK506 binding protein 7	76.49(n) 78.95(a)		424129 XM_421981.3 XP_421981.3
lizard (Anolis carolinensis)	Reptilia	FKBP7⁶	--	67(a)	1 ↔ 1	GL343320.1(1101113-1109825)
African clawed frog (Xenopus laevis)	Amphibia	Xl.2913²	Xenopus laevis transcribed sequence with weak similarity more	74.93(n)		CB207789.1
zebrafish (Danio rerio)	Actinopterygii	fkbp7¹	FK506 binding protein 7	61.57(n) 58.8(a)		368498 NM_001004506.1 NP_001004506.1
fruit fly (Drosophila melanogaster)	Insecta	Fkbp13³	FK506 binding	41(a)		--
thale cress (Arabidopsis thaliana)	eudicotyledons	FKBP15-1⁶ FKBP15-2⁶ (see all 4)	FK506-binding protein 2-2 (see all 4)	29(a) 28(a) (see all 4)	many ↔ many many ↔ many (see all 4)	3(9182616-9184679) 5(19695929-19698712)
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	peptidyl-prolyl cis-trans isomerase, FKBP-type, pu... peptidyl-prolyl cis-trans isomerase, FKBP-type, pu... (see all 4)	31(a) 28(a) (see all 4)	many ↔ many many ↔ many (see all 4)	9(19414912-19417619) 1(39912847-39915451)

ENSEMBL Gene Tree for FKBP7 (if available)
TreeFam Gene Tree for FKBP7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FKBP7 gene

FKBP11² FKBP2² FKBP14² FKBP10² FKBP9²

10 SIMAP similar genes for FKBP7 using alignment to 6 protein entries: FKBP7_HUMAN (see all proteins):

FKBP14 FKBP12-Exip2 FKBP2 FKBP9 FKBP10 FKBP1A

FKBP1C FKBP1B FKBP11 FKBP4

FKBP7 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for FKBP7
PGOHUM00000243803

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12619401^1,2	C,H	--	179327978(+)	`TAGGCC/GGACTA`	2	--	ds500¹		0	--	--	--	--
rs184500735^1,2		--	179328103(+)	`ACAGGA/CGGTAA`	2	--	ds500¹		0	--	--	--	--
rs7340184^1,2	C	--	179328132(+)	`attgcC/Ttgaga`	2	--	ds500¹		0	--	--	--	--
rs1863670^1,2	C	--	179328144(+)	`cacagC/Tgggag`	2	--	ds500¹		2		NA MN	186
rs11687811^1,2	C,F,H	--	179328145(+)	`ACAGCG/AGGAGG`	2	--	ds500¹		3		NA	8
rs188496429^1,2		--	179328209(+)	`TTGGGG/TCGCCT`	2	--	ds500¹		0	--	--	--	--
rs77049178^1,2	F	--	179328354(+)	`ATAAGG/ACAATC`	2	--	ds500¹		1		WA	118
rs7340277^1,2	C,H	--	179328468(+)	`TCATGT/GGGCAT`	2	--	ut3¹		4		NS EA	420
rs142309441^1,2	C	--	179328837(+)	`ACCCC-/TATGTA`	2	--	ut3¹		0	--	--	--	--
rs143138829^1,2	C	--	179328847(+)	`ATACT-/TTTG TTTGT`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FKBP7 (179328391 - 179343355 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FKBP7: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FKBP7

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FKBP7 for disorders About MalaCards

FKBP7 for disorders About GeneDecksing

OMIM gene information: 607062 OMIM disorders: --

Export disorders for FKBP7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FKBP7 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with FKBP7)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Molecular cloning, characterization, and chromosomal localization of FKBP23, a novel FK506-binding protein with Ca2+-binding ability. (PubMed id 9806833)^{1, 3} Nakamura T....Honjo T. (1998)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Transcriptional regulation of Oct4 by a long non-codi ng RNA antisense to Oct4-pseudogene 5. (PubMed id 21151833)¹ Hawkins P.G. and Morris K.V. (2010)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W....Wilson R.K. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51661	HGNC: 3723	AceView: FKBP7	Ensembl:ENSG00000079150	euGenes: HUgn51661
ECgene: FKBP7	H-InvDB: FKBP7

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for FKBP7	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FKBP7 gene
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Patent Information for FKBP7 gene:
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FK506 binding protein 7

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FK506 binding protein 7

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