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Aliases for FKBP7 Gene

Aliases for FKBP7 Gene

  • FK506 Binding Protein 7 2 3
  • FK506-Binding Protein 7 2 3 4
  • 23 KDa FK506-Binding Protein 3 4
  • PPIase FKBP7 3 4
  • 23 KDa FKBP 3 4
  • Rotamase 3 4
  • FKBP-23 3 4
  • FKBP-7 3 4
  • FKBP23 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase FKBP7 3
  • FK506-Binding Protein 23 3
  • EC 5.2.1.8 4
  • PPIASE 3

External Ids for FKBP7 Gene

Summaries for FKBP7 Gene

Entrez Gene Summary for FKBP7 Gene

  • The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. Members of this family exhibit PPIase activity and function as molecular chaperones. A similar protein in mouse is located in the endoplasmic reticulum and binds calcium. [provided by RefSeq, Jul 2008]

GeneCards Summary for FKBP7 Gene

FKBP7 (FK506 Binding Protein 7) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and FK506 binding. An important paralog of this gene is FKBP9.

UniProtKB/Swiss-Prot for FKBP7 Gene

  • PPIases accelerate the folding of proteins during protein synthesis

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBP7 Gene

Genomics for FKBP7 Gene

Genomic Location for FKBP7 Gene

Start:
178,463,664 bp from pter
End:
178,478,916 bp from pter
Size:
15,253 bases
Orientation:
Minus strand

Genomic View for FKBP7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FKBP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP7 Gene

Regulatory Elements for FKBP7 Gene

Proteins for FKBP7 Gene

  • Protein details for FKBP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y680-FKBP7_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP7
    Protein Accession:
    Q9Y680
    Secondary Accessions:
    • Q4ZG70
    • Q6V3B2
    • Q86U65
    • Q96DA4
    • Q9Y6B0

    Protein attributes for FKBP7 Gene

    Size:
    259 amino acids
    Molecular mass:
    30009 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Binds calcium.

    Alternative splice isoforms for FKBP7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FKBP7 Gene

Proteomics data for FKBP7 Gene at MOPED

Post-translational modifications for FKBP7 Gene

Other Protein References for FKBP7 Gene

No data available for DME Specific Peptides for FKBP7 Gene

Domains for FKBP7 Gene

Gene Families for FKBP7 Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for FKBP7 Gene

UniProtKB/Swiss-Prot:

FKBP7_HUMAN
Domain:
  • Contains 2 EF-hand domains.:
    • Q9Y680
  • Contains 1 PPIase FKBP-type domain.:
    • Q9Y680
genes like me logo Genes that share domains with FKBP7: view

Function for FKBP7 Gene

Molecular function for FKBP7 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Peptidylproline (omega=180) = peptidylproline (omega=0)
UniProtKB/Swiss-Prot Function: PPIases accelerate the folding of proteins during protein synthesis

Enzyme Numbers (IUBMB) for FKBP7 Gene

Gene Ontology (GO) - Molecular Function for FKBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 15846844
GO:0005528 FK506 binding IBA --
genes like me logo Genes that share ontologies with FKBP7: view

miRNA for FKBP7 Gene

miRTarBase miRNAs that target FKBP7

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FKBP7 Gene

Localization for FKBP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP7 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FKBP7 Gene COMPARTMENTS Subcellular localization image for FKBP7 gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 3
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FKBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005788 endoplasmic reticulum lumen IEA --
GO:0005789 endoplasmic reticulum membrane IBA --
genes like me logo Genes that share ontologies with FKBP7: view

Pathways for FKBP7 Gene

SuperPathways for FKBP7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FKBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IBA --
GO:0006457 protein folding --
GO:0061077 chaperone-mediated protein folding IBA --
genes like me logo Genes that share ontologies with FKBP7: view

No data available for Pathways by source for FKBP7 Gene

Compounds for FKBP7 Gene

(1) HMDB Compounds for FKBP7 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with FKBP7: view

Transcripts for FKBP7 Gene

Unigene Clusters for FKBP7 Gene

FK506 binding protein 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP7 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: -
SP2: - -
SP3: - -
SP4: - -
SP5: - -
SP6:
SP7: - - -
SP8: - -

Relevant External Links for FKBP7 Gene

GeneLoc Exon Structure for
FKBP7
ECgene alternative splicing isoforms for
FKBP7

Expression for FKBP7 Gene

mRNA expression in normal human tissues for FKBP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FKBP7 Gene

SOURCE GeneReport for Unigene cluster for FKBP7 Gene Hs.410378

genes like me logo Genes that share expressions with FKBP7: view

Orthologs for FKBP7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FKBP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FKBP7 36
  • 99.7 (n)
  • 99.55 (a)
FKBP7 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FKBP7 36
  • 90.83 (n)
  • 89.45 (a)
FKBP7 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FKBP7 36
  • 90.37 (n)
  • 89.45 (a)
FKBP7 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fkbp7 36
  • 85.02 (n)
  • 87.16 (a)
Fkbp7 16
Fkbp7 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FKBP7 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fkbp7 36
  • 85.47 (n)
  • 87.61 (a)
chicken
(Gallus gallus)
Aves FKBP7 36
  • 71.72 (n)
  • 72.51 (a)
FKBP7 37
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FKBP7 37
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2913 36
tropical clawed frog
(Silurana tropicalis)
Amphibia fkbp7 36
  • 68.53 (n)
  • 65.58 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10818 36
zebrafish
(Danio rerio)
Actinopterygii fkbp7 36
  • 61.57 (n)
  • 58.8 (a)
fkbp7 37
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Fkbp13 37
  • 37 (a)
OneToMany
Fkbp13 38
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea fkb-7 37
  • 17 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPR2 37
  • 38 (a)
OneToMany
Species with no ortholog for FKBP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FKBP7 Gene

ENSEMBL:
Gene Tree for FKBP7 (if available)
TreeFam:
Gene Tree for FKBP7 (if available)

Paralogs for FKBP7 Gene

Paralogs for FKBP7 Gene

Selected SIMAP similar genes for FKBP7 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for FKBP7 Gene

genes like me logo Genes that share paralogs with FKBP7: view

Variants for FKBP7 Gene

Sequence variations from dbSNP and Humsavar for FKBP7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1057164 -- 178,478,168(+) AACTT(C/T)TACCG intron-variant
rs1559908 -- 178,471,620(+) tgtca(C/T)cagta intron-variant
rs1863670 -- 178,463,417(+) CACAG(C/T)GGGAG downstream-variant-500B
rs1863671 -- 178,477,603(+) AATGG(C/T)ATATT intron-variant
rs3731756 -- 178,467,153(+) ACCAA(A/T)ATTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FKBP7 Gene

Variant ID Type Subtype PubMed ID
nsv834467 CNV Loss 17160897

Relevant External Links for FKBP7 Gene

HapMap Linkage Disequilibrium report
FKBP7

Disorders for FKBP7 Gene

Relevant External Links for FKBP7

Genetic Association Database (GAD)
FKBP7
genes like me logo Genes that share disorders with FKBP7: view

No data available for UniProtKB/Swiss-Prot for FKBP7 Gene

Publications for FKBP7 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Molecular cloning, characterization, and chromosomal localization of FKBP23, a novel FK506-binding protein with Ca2+-binding ability. (PMID: 9806833) Nakamura T. … Honjo T. (Genomics 1998) 2 3
  4. Molecular cloning of a novel ubiquitin-like protein, UBIN, that binds to ER targeting signal sequences. (PMID: 11162551) Matsuda M. … Nagata K. (Biochem. Biophys. Res. Commun. 2001) 3
  5. Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family. (PMID: 12036304) Patterson C.E. … Davis E.C. (Genomics 2002) 3

Products for FKBP7 Gene

Sources for FKBP7 Gene

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