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FKBP6 Gene

protein-coding   GIFtS: 58
GCID: GC07P072742

FK506 Binding Protein 6, 36kDa

(Previous name: FK506-binding protein 6 (36kD))
  See FKBP6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FK506 Binding Protein 6, 36kDa1 2     Peptidylprolyl Cis-Trans Isomerase1
Immunophilin FKBP361 2 3     Peptidyl-Prolyl Cis-Trans Isomerase FKBP62
rotamase1 2     36 KDa FK506-Binding Protein3
36 KDa FKBP2 3     EC 5.2.1.83
FKBP362 3     FKBP-363
PPIase FKBP62 3     FKBP-63
FK506 Binding Protein 6 (36kD)1     Rotamase3
FK506-Binding Protein 6 (36kD)1     FK506-Binding Protein 63

External Ids:    HGNC: 37221   Entrez Gene: 84682   Ensembl: ENSG000000778007   OMIM: 6048395   UniProtKB: O753443   

Export aliases for FKBP6 gene to outside databases

Previous GC identifers: GC07P071382 GC07P072140 GC07P072154 GC07P071886 GC07P072078 GC07P072380 GC07P068623


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FKBP6 Gene:
The protein encoded by this gene is a cis-trans peptidyl-prolyl isomerase that may function in immunoregulation
and basic cellular processes involving protein folding and trafficking. This gene is located in a chromosomal
region that is deleted in Williams-Beuren syndrome. Defects in this gene may cause male infertility. There are
multiple pseudogenes for this gene located nearby on chromosome 7. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, Jul 2013)

GeneCards Summary for FKBP6 Gene:
FKBP6 (FK506 binding protein 6, 36kDa) is a protein-coding gene. Diseases associated with FKBP6 include male infertility, and williams syndrome. GO annotations related to this gene include FK506 binding and peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is FKBP5.

UniProtKB/Swiss-Prot: FKBP6_HUMAN, O75344
Function: PPIases accelerate the folding of proteins




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FKBP6 gene promoter:
         STAT1   STAT2   STAT1beta   ITF-2   Tal-1beta   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FKBP6 promoter sequence
   Search Chromatin IP Primers for FKBP6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FKBP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.23   Ensembl cytogenetic band:  7q11.23   HGNC cytogenetic band: 7q11.23

FKBP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FKBP6 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P072742:  view genomic region     (about GC identifiers)

Start:
72,742,155 bp from pter      End:
72,772,641 bp from pter
Size:
30,487 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 72,075,227-72,105,713     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FKBP6_HUMAN, O75344 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase FKBP6  
Size: 327 amino acids; 37214 Da
1 PDB 3D structure from and Proteopedia for FKBP6:
3B7X (3D)    
Secondary accessions: B4DXT7 Q9UDS0
Alternative splicing: 2 isoforms:  O75344-1   O75344-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FKBP6: NX_O75344

Explore proteomics data for FKBP6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FKBP6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001128683.1  NP_001268233.1  NP_003593.3  

    ENSEMBL proteins: 
     ENSP00000416277   ENSP00000402360   ENSP00000394952   ENSP00000415891   ENSP00000403908  
     ENSP00000252037  
    Reactome Protein details: O75344

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR023566 PPIase_FKBP
     IPR001179 PPIase_FKBP_dom
     IPR013026 TPR-contain_dom

    Graphical View of Domain Structure for InterPro Entry O75344

    ProtoNet protein and cluster: O75344

    UniProtKB/Swiss-Prot: FKBP6_HUMAN, O75344
    Similarity: Contains 1 PPIase FKBP-type domain
    Similarity: Contains 3 TPR repeats


    Find genes that share domains with FKBP6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FKBP6_HUMAN, O75344
    Function: PPIases accelerate the folding of proteins
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)

         Genatlas biochemistry entry for FKBP6:
    FK506-binding protein6,T cell binding protein FKBP for the immunosuppressive agents FK506-rapamycin expressed in
    testis,heart,skeletal muscle,liver and kidney,deleted in Williams syndrome

         Enzyme Number (IUBMB): EC 5.2.1.81

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755NOT peptidyl-prolyl cis-trans isomerase activity ISS--
    GO:0005515protein binding ----
    GO:0005528FK506 binding IBA--
    GO:0051879Hsp90 protein binding ISS--
         
    Find genes that share ontologies with FKBP6           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FKBP6:
     Increased cell number in G1, s 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fkbp6):
     endocrine/exocrine gland  reproductive system 

    Find genes that share phenotypes with FKBP6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fkbp6tm1Pngr for FKBP6

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FKBP6
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    hsa-miR-222* hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3065-5p hsa-miR-3129-5p hsa-miR-548o hsa-miR-570 hsa-miR-1323
    SwitchGear 3'UTR luciferase reporter plasmidFKBP6 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for FKBP6 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    extracellular1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000795synaptonemal complex ISS--
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol ISS--
    GO:0016020membrane IBA--

    Find genes that share ontologies with FKBP6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FKBP6 About    
    See pathways by source

    SuperPathContained pathways About
    1Packaging Of Telomere Ends
    Meiotic Synapsis0.66
    Chromosome Maintenance0.62
    2Cell Cycle, Mitotic
    Cell Cycle0.90
    3Meiosis (REACTOME)
    Meiosis0.74


    Find genes that share SuperPaths with FKBP6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for FKBP6
        Meiotic synapsis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FKBP6
    Interactions:

        Search GeneGlobe Interaction Network for FKBP6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FKBP6 (O753442, 3 ENSP000002520374) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCNKO759092, 3, ENSP000003745294MINT-66761 I2D: score=5 STRING: ENSP00000374529
    NME7Q9Y5B82, 3, ENSP000003567854MINT-66560 I2D: score=5 STRING: ENSP00000356785
    GAPDHP044063, ENSP000002292394I2D: score=1 STRING: ENSP00000229239
    HSP90AA1P079003, ENSP000003351534I2D: score=1 STRING: ENSP00000335153
    TBC1D17Q9HA653I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000413protein peptidyl-prolyl isomerization ----
    GO:0006457protein folding ISS--
    GO:0007126meiotic nuclear division ISS--
    GO:0007283spermatogenesis ISS--
    GO:0018208peptidyl-proline modification IBA--

    Find genes that share ontologies with FKBP6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FKBP6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FKBP6 gene (3 alternative transcripts): 
    NM_001135211.2  NM_001281304.1  NM_003602.4  

    Unigene Cluster for FKBP6:

    FK506 binding protein 6, 36kDa
    Hs.661266  [show with all ESTs]
    Unigene Representative Sequence: NM_003602
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000431982(uc011kew.1) ENST00000442793 ENST00000413573(uc003twz.2)
    ENST00000445032(uc003tya.2) ENST00000429879(uc010lbe.1) ENST00000437013
    ENST00000252037
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FKBP6 (see all 10):
    hsa-miR-222* hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3065-5p hsa-miR-3129-5p hsa-miR-548o hsa-miR-570 hsa-miR-1323
    SwitchGear 3'UTR luciferase reporter plasmidFKBP6 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat FKBP6
      QuantiFast Probe-based Assays in human, mouse, rat FKBP6

    Additional mRNA sequence: 

    AF038847.1 AK302121.1 AK310255.1 BC036817.1 

    6 DOTS entries:

    DT.309473  DT.101981340  DT.91685900  DT.95255279  DT.97774787  DT.97783554 

    22 AceView cDNA sequences:

    AA078227 BC067783 AA843562 AA078495 BV176501 BV176436 BG722503 AI190559 
    BM981791 AI184590 BG720247 BI825663 BV176079 AA446529 BC022013 AA077532 
    BF870204 AI873214 AA446348 AW118983 AA078005 BU853536 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FKBP6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACGCGGCTG
    FKBP6 Expression
    About this image


    FKBP6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Gonad
             XY Germ Cells Testis Cord
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Ovary (Reproductive System)
             XX Germ Cells Ovigerous Cord
    FKBP6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FKBP6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.661266

    UniProtKB/Swiss-Prot: FKBP6_HUMAN, O75344
    Tissue specificity: Detected in all tissues examined, with higher expression in testis, heart, skeletal muscle,
    liver, and kidney

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FKBP6 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fkbp61 , 5 FK506 binding protein 61, 5 83.17(n)1
    86.97(a)1
      5 (75.11 cM)5
    942441  NM_033571.31  NP_291049.11 
     1352917045 
    chicken
    (Gallus gallus)
    Aves FKBP61 FK506 binding protein 6, 36kDa 67.68(n)
    67.05(a)
      417460  XM_415708.4  XP_415708.4 
    lizard
    (Anolis carolinensis)
    Reptilia FKBP66
    FK506 binding protein 6, 36kDa
    54(a)
    1 ↔ 1
    5(63496701-63519409)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.195292 Xenopus laevis transcribed sequence with weak similarity more 72.94(n)    BJ028858.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.265962 Danio rerio cDNA clone IMAGE5411885, partial cds 72.92(n)    BC054673.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta shu1 shutdown 45.12(n)
    29.63(a)
      45360  NM_137993.3  NP_611837.1 


    ENSEMBL Gene Tree for FKBP6 (if available)
    TreeFam Gene Tree for FKBP6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FKBP6 gene
    FKBP52  FKBP1A2  FKBP1C2  FKBP42  FKBP82  FKBP1B2  FKBP32  
    5 SIMAP similar genes for FKBP6 using alignment to 5 protein entries:     FKBP6_HUMAN (see all proteins):
    FKBP1C    FKBP1A    FKBP12-Exip2    FKBP1B    FKBP10

    Find genes that share paralogs with FKBP6           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for FKBP6
    PGOHUM00000250883 PGOHUM00000250942


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FKBP6 (see all 658)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58849071,2
    C,F--68637400(+) GTCACT/-ttttt 2 -- int1 trp32Minor allele frequency- -:0.50NA 4
    rs2018126071,2
    --72080356(+) AAAAA-/ACAAAAC 2 -- int10--------
    rs285013241,2
    C--72080357(+) AAAAAA/CAAAAC 2 -- int12Minor allele frequency- C:0.00WA 4
    rs679492331,2
    C--72080357(-) GTTTT-/GTTTTT 2 -- int12Minor allele frequency- G:0.25NA CSA 4
    rs3682276451,2
    C--72087992(+) TGTCT-/T/TTT 
            
    TTTTT
    4 -- int1 cds10--------
    rs106958411,2
    C--72088012(+) tttttTTT/-agaca 2 -- cds11Minor allele frequency- -:0.00NA 2
    rs681680251,2
    C--72095225(+) ACCTC-/CTTC  
      AGGGAT
    CTTCT
    2 -- int11Minor allele frequency- CTTCAGGGAT:0.00CSA 2
    rs112799231,2
    C--72095229(+) CCTTC-/AGGG  
      ATCTTC
    TATTC
    2 -- int11Minor allele frequency- AGGGATCTTC:0.00NA 2
    rs102749401,2
    C--72105083(+) aaaaaA/GGTTTC 2 -- int1 trp30--------
    rs106512871,2
    C--72749137(+) AAAAAAA/-GTCCT 2 -- int1 trp31Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for FKBP6 (72742155 - 72772641 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for FKBP6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831027CNV Loss17160897
    dgv7324n71CNV Gain21882294
    esv34349CNV Gain17911159
    nsv888362CNV Gain21882294
    nsv520573CNV Gain+Loss19592680
    dgv2099e1CNV Complex17122850
    dgv2095e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): FKBP6
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing FKBP6
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604839    OMIM disorders: --

    UniProtKB/Swiss-Prot: FKBP6_HUMAN, O75344
  • Note=FKBP6 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a
    hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing
    over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of FKBP6
    may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease

  • 4 diseases for FKBP6:    
    About MalaCards
    male infertility    williams syndrome    infertility    williams-beuren syndrome


    Find genes that share disorders with FKBP6           About GenesLikeMe

    2 Novoseek inferred disease relationships for FKBP6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    williams syndrome 80 1 15770126 (1)
    azoospermia 72 2 15516791 (1), 16983454 (1)

    Genetic Association Database (GAD): FKBP6
    Human Genome Epidemiology (HuGE) Navigator: FKBP6 (5 documents)

    Export disorders for FKBP6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FKBP6 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with FKBP6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human gene FKBP6 is deleted in Williams syndrome. (PubMed id 9782077)1, 2, 3, 9 Meng X.... Keating M.T. (Genomics 1998)
    2. Mutations in the chromosome pairing gene FKBP6 are not a common cause of non-obstructive azoospermia. (PubMed id 16227348)1, 4, 9 Westerveld G.H....van der Veen F. (Mol. Hum. Reprod. 2005)
    3. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PubMed id 20378615)1, 4 Aston K.I....Carrell D.T. (Hum. Reprod. 2010)
    4. FKBP36 is an inherent multifunctional glyceraldehyde-3-phosphate dehydrogenase inhibitor. (PubMed id 19001379)1, 3 Jarczowski F....Edlich F. (J. Biol. Chem. 2009)
    5. Mutation screening of the FKBP6 gene and its association study with spermatogenic impairment in idiopathic infertile men. (PubMed id 17307919)1, 4 Zhang W....Zhoucun A. (Reproduction 2007)
    6. [Possible association between 278C/A single nucleotide polymorphism of FKBP6 and idiopathic azoospermia]. (PubMed id 15696470)1, 4 Zhang W....Shi J.J. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Is a genetic defect in Fkbp6 a common cause of azoospermia in humans? (PubMed id 16983454)1, 9 Miyamato T....Sengoku K. (amp 2006)
    9. Autosomal dominant inheritance of Williams-Beuren syndrome in a father and son with haploinsufficiency for FKBP6. (PubMed id 15770126)1, 9 Metcalfe K....Tassabehji M. (Clin. Dysmorphol. 2005)
    10. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)1 Kennedy R.B....Poland G.A. (Hum. Genet. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8468 HGNC: 3722 AceView: FKBP6.2 Ensembl:ENSG00000077800 euGenes: HUgn8468
    ECgene: FKBP6 H-InvDB: FKBP6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FKBP6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FKBP6 gene:
    Search GeneIP for patents involving FKBP6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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