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Aliases for FKBP5 Gene

Aliases for FKBP5 Gene

  • FK506 Binding Protein 5 2 3 5
  • 54 KDa Progesterone Receptor-Associated Immunophilin 3 4
  • 51 KDa FK506-Binding Protein 3 4
  • Androgen-Regulated Protein 6 3 4
  • HSP90-Binding Immunophilin 3 4
  • FK506-Binding Protein 5 2 4
  • PPIase FKBP5 3 4
  • 51 KDa FKBP 3 4
  • FF1 Antigen 3 4
  • EC 5.2.1.8 4 58
  • Rotamase 3 4
  • FKBP-51 3 4
  • FKBP51 3 4
  • FKBP54 3 4
  • AIG6 3 4
  • P54 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase FKBP5 3
  • Peptidylprolyl Cis-Trans Isomerase 3
  • T-Cell FK506-Binding Protein 3
  • PPIASE 3
  • Ptg-10 3
  • FKBP-5 4

External Ids for FKBP5 Gene

Previous GeneCards Identifiers for FKBP5 Gene

  • GC06M035543
  • GC06M035588
  • GC06M035649
  • GC06M035541
  • GC06M035262
  • GC06M035982
  • GC06M035993
  • GC06M036299
  • GC06M036668
  • GC06M037021
  • GC06M037371

Summaries for FKBP5 Gene

Entrez Gene Summary for FKBP5 Gene

  • The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

GeneCards Summary for FKBP5 Gene

FKBP5 (FK506 Binding Protein 5) is a Protein Coding gene. Diseases associated with FKBP5 include Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment and Post-Traumatic Stress Disorder. Among its related pathways are Glucocorticoid receptor regulatory network and Relaxin signaling pathway. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and FK506 binding. An important paralog of this gene is FKBP4.

UniProtKB/Swiss-Prot for FKBP5 Gene

  • Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded.

Gene Wiki entry for FKBP5 Gene

Additional gene information for FKBP5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBP5 Gene

Genomics for FKBP5 Gene

Regulatory Elements for FKBP5 Gene

Enhancers for FKBP5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H036592 3 FANTOM5 Ensembl ENCODE dbSUPER 18.5 -868.8 -868836 10 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A SRSF3 KCTD20 CDKN1A LAP3P2 RAB44 STK38 ENSG00000237719 FKBP5 BRPF3 RNU1-88P
GH06H036660 1.8 FANTOM5 Ensembl ENCODE dbSUPER 18.5 -932.4 -932380 0 HDAC1 YBX3 HDGF ATF1 RB1 ARNT YBX1 NFXL1 ZBTB40 EGR1 CDKN1A FKBP5 RAB44 ETV7 SRSF3 KCTD20 ENSG00000251864 RNU1-88P GC06M037949
GH06H035341 1.8 FANTOM5 ENCODE dbSUPER 18.5 +385.3 385336 3 HNRNPUL1 HDGF PKNOX1 MLX ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 TAF11 FANCE FKBP5 RPS10 RPL10A PPARD TEAD3 BRPF3 ENSG00000219023 MAPK14
GH06H034886 1.4 ENCODE dbSUPER 18.5 +838.9 838889 5 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 ZNF610 UHRF1BP1 FKBP5 RPS10 TEAD3 RPL10A TCP11 ANKS1A PIR53548 GC06P041213
GH06H035594 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.6 +128.8 128770 9 PKNOX1 FOXA2 ARID4B FEZF1 FOS RUNX3 SP3 TSHZ1 PPARG NFIL3 TAF11 ENSG00000272374 ZNF76 FKBP5 ENSG00000212579 ENSG00000232909 ARMC12 ENSG00000228559 BRPF3 ANKS1A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FKBP5 on UCSC Golden Path with GeneCards custom track

Promoters for FKBP5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000320429 483 601 HDGF FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF766 CBX5 ZNF207 SP3

Genomic Location for FKBP5 Gene

Chromosome:
6
Start:
35,573,585 bp from pter
End:
35,728,583 bp from pter
Size:
154,999 bases
Orientation:
Minus strand

Genomic View for FKBP5 Gene

Genes around FKBP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FKBP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FKBP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP5 Gene

Proteins for FKBP5 Gene

  • Protein details for FKBP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13451-FKBP5_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP5
    Protein Accession:
    Q13451
    Secondary Accessions:
    • F5H7R1
    • Q59EB8
    • Q5TGM6

    Protein attributes for FKBP5 Gene

    Size:
    457 amino acids
    Molecular mass:
    51212 Da
    Quaternary structure:
    • Part of a heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B and steroid receptors. Upon ligand binding dissociates from the complex and FKBP4 takes its place. Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
    SequenceCaution:
    • Sequence=BAD93130.1; Type=Frameshift; Positions=29; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FKBP5 Gene

    Alternative splice isoforms for FKBP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FKBP5 Gene

Selected DME Specific Peptides for FKBP5 Gene

Q13451:
  • KIVSWLE
  • FEIELLDF
  • EQGEDIT
  • KAKEHNERDRR
  • GEGYSNPNEGA
  • KKDRGVLKIVKRVG
  • ETPMIGD
  • GKKFDSS
  • CKPEYAYG
  • FESAKGDFEKVL
  • LKSFEKAK
  • KLREYTKAVECCDKALGLDSAN
  • AARLQISMCQ
  • EDGGIIRR

Post-translational modifications for FKBP5 Gene

  • Ubiquitination at isoforms=352 and posLast=376376
  • Modification sites at PhosphoSitePlus

Other Protein References for FKBP5 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FKBP5 (FKBP5)
  • Santa Cruz Biotechnology (SCBT) Antibodies for FKBP5

Domains & Families for FKBP5 Gene

Gene Families for FKBP5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FKBP5: view

No data available for UniProtKB/Swiss-Prot for FKBP5 Gene

Function for FKBP5 Gene

Molecular function for FKBP5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by FK506 but not cyclosporin.
UniProtKB/Swiss-Prot Function:
Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded.
UniProtKB/Swiss-Prot Induction:
By androgen.

Enzyme Numbers (IUBMB) for FKBP5 Gene

Phenotypes From GWAS Catalog for FKBP5 Gene

Gene Ontology (GO) - Molecular Function for FKBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IDA 11350175
GO:0005515 protein binding IPI 14676191
GO:0005528 FK506 binding IBA,TAS --
GO:0016853 isomerase activity IEA --
GO:0031072 heat shock protein binding IPI 9660753
genes like me logo Genes that share ontologies with FKBP5: view
genes like me logo Genes that share phenotypes with FKBP5: view

Animal Models for FKBP5 Gene

MGI Knock Outs for FKBP5:

Animal Model Products

  • Taconic Biosciences Mouse Models for FKBP5

CRISPR Products

miRNA for FKBP5 Gene

miRTarBase miRNAs that target FKBP5

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FKBP5
  • Applied Biological Materials Clones for FKBP5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FKBP5 Gene

Localization for FKBP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP5 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FKBP5 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FKBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with FKBP5: view

Pathways & Interactions for FKBP5 Gene

genes like me logo Genes that share pathways with FKBP5: view

Pathways by source for FKBP5 Gene

1 Cell Signaling Technology pathway for FKBP5 Gene
1 KEGG pathway for FKBP5 Gene

Gene Ontology (GO) - Biological Process for FKBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0006457 protein folding TAS 9001212
GO:0061077 chaperone-mediated protein folding IDA 11350175
genes like me logo Genes that share ontologies with FKBP5: view

No data available for SIGNOR curated interactions for FKBP5 Gene

Drugs & Compounds for FKBP5 Gene

(22) Drugs for FKBP5 Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Progesterone Approved, Vet_approved Pharma Full agonist, Activator Endogenous progesterone receptor agonist 578
Citalopram Approved Pharma 520
Clomipramine Approved, Vet_approved Pharma 24
Clozapine Approved Pharma Antagonist Antipsychotic medication 120
Escitalopram Approved, Investigational Pharma 0

(3) Additional Compounds for FKBP5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FKBP5: view

Transcripts for FKBP5 Gene

Unigene Clusters for FKBP5 Gene

FK506 binding protein 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FKBP5
  • Applied Biological Materials Clones for FKBP5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^
SP1: - - - - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - -
SP4: - -
SP5: -
SP6: - - - -
SP7: -
SP8:

ExUns: 20a · 20b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for FKBP5 Gene

GeneLoc Exon Structure for
FKBP5
ECgene alternative splicing isoforms for
FKBP5

Expression for FKBP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FKBP5 Gene

mRNA differential expression in normal tissues according to GTEx for FKBP5 Gene

This gene is overexpressed in Muscle - Skeletal (x8.8) and Whole Blood (x4.0).

Protein differential expression in normal tissues from HIPED for FKBP5 Gene

This gene is overexpressed in Lymph node (18.1) and Peripheral blood mononuclear cells (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FKBP5 Gene



Protein tissue co-expression partners for FKBP5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FKBP5 Gene:

FKBP5

SOURCE GeneReport for Unigene cluster for FKBP5 Gene:

Hs.407190

mRNA Expression by UniProt/SwissProt for FKBP5 Gene:

Q13451-FKBP5_HUMAN
Tissue specificity: Widely expressed, enriched in testis compared to other tissues.

Evidence on tissue expression from TISSUES for FKBP5 Gene

  • Nervous system(4.9)
  • Liver(4.5)
  • Adrenal gland(3.2)
  • Kidney(2.7)
  • Muscle(2.7)
  • Lung(2.6)
  • Spleen(2.6)
  • Blood(2.5)
  • Heart(2.5)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with FKBP5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FKBP5 Gene

Orthologs for FKBP5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FKBP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FKBP5 33 34
  • 99.93 (n)
cow
(Bos Taurus)
Mammalia FKBP5 33 34
  • 93.07 (n)
dog
(Canis familiaris)
Mammalia FKBP5 33 34
  • 92.4 (n)
oppossum
(Monodelphis domestica)
Mammalia FKBP5 34
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fkbp5 33
  • 86.26 (n)
mouse
(Mus musculus)
Mammalia Fkbp5 33 16 34
  • 84.58 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-7424 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves FKBP51 34
  • 84 (a)
OneToOne
FKBP5 33
  • 76.39 (n)
lizard
(Anolis carolinensis)
Reptilia FKBP5 34
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fkbp5 33 34
  • 63.82 (n)
fruit fly
(Drosophila melanogaster)
Insecta FKBP59 35 34
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea fkb-6 35 34
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPR1 34
  • 43 (a)
OneToMany
FPR3 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 51 (a)
ManyToMany
Species where no ortholog for FKBP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FKBP5 Gene

ENSEMBL:
Gene Tree for FKBP5 (if available)
TreeFam:
Gene Tree for FKBP5 (if available)

Paralogs for FKBP5 Gene

Paralogs for FKBP5 Gene

(6) SIMAP similar genes for FKBP5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FKBP5: view

Variants for FKBP5 Gene

Sequence variations from dbSNP and Humsavar for FKBP5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs4713916 drug-response 35,702,206(+) CCTCT(A/G)TTGCA intron-variant
rs1000006055 -- 35,677,287(+) CCAGA(A/G)TGGTC intron-variant
rs1000008493 -- 35,722,868(+) GGAGG(A/G)CAGCG intron-variant
rs1000032321 -- 35,670,503(+) CTGAG(A/G)CGGGT intron-variant
rs1000043343 -- 35,605,912(+) AAAAA(C/G)AAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FKBP5 Gene

Variant ID Type Subtype PubMed ID
dgv10626n54 CNV gain 21841781
dgv10627n54 CNV gain 21841781
dgv10628n54 CNV loss 21841781
dgv10629n54 CNV loss 21841781
dgv1176e214 CNV gain 21293372
dgv178n73 CNV deletion 24416366
dgv26e209 CNV deletion 24192839
dgv5956n100 CNV gain 25217958
dgv5957n100 CNV gain 25217958
dgv751n27 CNV gain 19166990
esv1163117 CNV insertion 17803354
esv1362467 CNV deletion 17803354
esv1964718 CNV deletion 18987734
esv2169093 CNV deletion 18987734
esv2421382 CNV duplication 20811451
esv25611 CNV gain 19812545
esv2603863 CNV deletion 19546169
esv2669578 CNV deletion 23128226
esv2731911 CNV deletion 23290073
esv2731912 CNV deletion 23290073
esv2731913 CNV deletion 23290073
esv2759420 CNV gain 17122850
esv2761067 CNV gain 21179565
esv29881 CNV loss 19812545
esv3567630 CNV deletion 23714750
esv3567631 CNV deletion 23714750
esv3608680 CNV gain 21293372
esv3608684 CNV loss 21293372
esv3608688 CNV loss 21293372
esv3608689 CNV gain 21293372
esv3608690 CNV gain 21293372
esv3890842 CNV gain 25118596
esv5263 CNV loss 18987735
esv6703 CNV loss 19470904
esv7205 CNV gain 19470904
esv987803 CNV deletion 20482838
nsv1028947 CNV gain 25217958
nsv1072667 CNV deletion 25765185
nsv1128227 CNV deletion 24896259
nsv1142008 OTHER inversion 24896259
nsv428143 CNV gain 18775914
nsv441992 CNV gain 18776908
nsv462913 CNV gain 19166990
nsv470813 CNV gain 18288195
nsv478643 CNV novel sequence insertion 20440878
nsv499295 CNV loss 21111241
nsv508403 CNV deletion 20534489
nsv511349 CNV loss 21212237
nsv511880 CNV loss 21212237
nsv512875 CNV insertion 21212237
nsv514355 CNV loss 21397061
nsv517211 CNV gain 19592680
nsv5258 CNV deletion 18451855
nsv602923 CNV gain 21841781
nsv602924 CNV gain 21841781
nsv602927 CNV gain+loss 21841781
nsv7379 OTHER inversion 18451855
nsv7889 CNV gain 18304495
nsv7890 CNV gain 18304495
nsv818412 CNV gain 17921354
nsv820606 CNV deletion 20802225
nsv821646 CNV loss 15273396
nsv958376 CNV deletion 24416366
nsv965719 CNV duplication 23825009

Variation tolerance for FKBP5 Gene

Residual Variation Intolerance Score: 40.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FKBP5 Gene

Human Gene Mutation Database (HGMD)
FKBP5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FKBP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FKBP5 Gene

Disorders for FKBP5 Gene

MalaCards: The human disease database

(7) MalaCards diseases for FKBP5 Gene - From: HGMD, OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
major depressive disorder and accelerated response to antidepressant drug treatment
  • unipolar depression
post-traumatic stress disorder
  • traumatic neurosis
glucocorticoid resistance
  • cortisol resistance from glucocorticoid receptor defect
ocular hypertension
borderline personality disorder
- elite association - COSMIC cancer census association via MalaCards
Search FKBP5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FKBP5

Genetic Association Database (GAD)
FKBP5
Human Genome Epidemiology (HuGE) Navigator
FKBP5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FKBP5
genes like me logo Genes that share disorders with FKBP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FKBP5 Gene

Publications for FKBP5 Gene

  1. Assessment of SNPs associated with the human glucocorticoid receptor in primary open-angle glaucoma and steroid responders. (PMID: 20376328) Fingert JH … Clark AF (Molecular vision 2010) 3 22 45 60
  2. Differential expression of immunophilins FKBP51 and FKBP52 in the frontal cortex of HIV-infected patients with major depressive disorder. (PMID: 19199039) Tatro ET … HIV Neurobehavioral Research Center (Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2009) 3 22 45 60
  3. Genetic variants in FKBP5 affecting response to antidepressant drug treatment. (PMID: 18597649) Kirchheiner J … Brockmöller J (Pharmacogenomics 2008) 3 22 45 60
  4. Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. (PMID: 18349090) Binder EB … Ressler KJ (JAMA 2008) 3 22 45 60
  5. The FKBP5-gene in depression and treatment response--an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Cohort. (PMID: 18191112) Lekman M … Paddock S (Biological psychiatry 2008) 3 22 45 60

Products for FKBP5 Gene

  • Addgene plasmids for FKBP5

Sources for FKBP5 Gene

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