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Aliases for FKBP5 Gene

Aliases for FKBP5 Gene

  • FK506 Binding Protein 5 2 3 5
  • 54 KDa Progesterone Receptor-Associated Immunophilin 3 4
  • 51 KDa FK506-Binding Protein 3 4
  • Androgen-Regulated Protein 6 3 4
  • HSP90-Binding Immunophilin 3 4
  • FK506-Binding Protein 5 2 4
  • PPIase FKBP5 3 4
  • 51 KDa FKBP 3 4
  • FF1 Antigen 3 4
  • EC 4 61
  • Rotamase 3 4
  • FKBP-51 3 4
  • FKBP51 3 4
  • FKBP54 3 4
  • AIG6 3 4
  • P54 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase FKBP5 3
  • Peptidylprolyl Cis-Trans Isomerase 3
  • T-Cell FK506-Binding Protein 3
  • PPIASE 3
  • Ptg-10 3
  • FKBP-5 4

External Ids for FKBP5 Gene

Previous GeneCards Identifiers for FKBP5 Gene

  • GC06M035543
  • GC06M035588
  • GC06M035649
  • GC06M035541
  • GC06M035262
  • GC06M035982
  • GC06M035993
  • GC06M036299
  • GC06M036668

Summaries for FKBP5 Gene

Entrez Gene Summary for FKBP5 Gene

  • The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

GeneCards Summary for FKBP5 Gene

FKBP5 (FK506 Binding Protein 5) is a Protein Coding gene. Diseases associated with FKBP5 include Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment and Post-Traumatic Stress Disorder. Among its related pathways are PI3K / Akt Signaling and Glucocorticoid receptor regulatory network. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and FK506 binding. An important paralog of this gene is FKBP4.

UniProtKB/Swiss-Prot for FKBP5 Gene

  • Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded.

Gene Wiki entry for FKBP5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBP5 Gene

Genomics for FKBP5 Gene

Regulatory Elements for FKBP5 Gene

Enhancers for FKBP5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F035594 1.7 FANTOM5 Ensembl ENCODE 13.6 +128.8 128770 9.9 PKNOX1 ARID4B SIN3A FEZF1 ZNF48 ZNF121 FOS SP3 TSHZ1 PPARG FKBP5 ENSG00000212579 ENSG00000232909 ARMC12 ENSG00000228559 TULP1 DEF6 MAPK14 RPL10A PPARD
GH06F035686 1.1 ENCODE 13.1 +40.8 40766 3.6 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 ENSG00000272374 FKBP5 ARMC12 ENSG00000232909 ENSG00000212579 ENSG00000237719 ENSG00000219023 FANCE SRPK1 MAPK14
GH06F036094 1.3 Ensembl ENCODE 9.6 -367.6 -367572 3.9 HDGF ARNT MLX ARID4B DMAP1 ZNF2 YY1 SLC30A9 ZNF143 PAF1 SLC26A8 MAPK13 BRPF3 LOC102723648 ARMC12 ENSG00000232909 FKBP5 SRPK1 TEAD3 ENSG00000237719
GH06F035973 1.2 Ensembl ENCODE 10 -245.3 -245263 1.2 PKNOX1 MLX ARID4B DMAP1 YY1 SLC30A9 JUNB PPARG KAT8 MAFF SRPK1 SLC26A8 MAPK13 CLPS ENSG00000232909 FKBP5 ARMC12 LOC105375035 DPRXP2
GH06F035662 1 Ensembl ENCODE 11.9 +64.4 64383 4.0 BCOR KLF1 ZMYM3 CHAMP1 ZFHX2 SCRT2 MAFK EGR2 SMARCA5 NR3C1 FKBP5 ARMC12 ENSG00000232909 MAPK14 PPARD GC06M037519 MIR5690
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FKBP5 on UCSC Golden Path with GeneCards custom track

Promoters for FKBP5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001880146 583 801 HDGF ARNT CREB3L1 ARID4B SIN3A DMAP1 CBX5 ZNF207 KLF13 SP3

Genomic Location for FKBP5 Gene

35,573,585 bp from pter
35,728,583 bp from pter
154,999 bases
Minus strand

Genomic View for FKBP5 Gene

Genes around FKBP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FKBP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FKBP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP5 Gene

Proteins for FKBP5 Gene

  • Protein details for FKBP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP5
    Protein Accession:
    Secondary Accessions:
    • F5H7R1
    • Q59EB8
    • Q5TGM6

    Protein attributes for FKBP5 Gene

    457 amino acids
    Molecular mass:
    51212 Da
    Quaternary structure:
    • Part of a heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B and steroid receptors. Upon ligand binding dissociates from the complex and FKBP4 takes its place. Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.
    • Sequence=BAD93130.1; Type=Frameshift; Positions=29; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FKBP5 Gene

    Alternative splice isoforms for FKBP5 Gene


neXtProt entry for FKBP5 Gene

Selected DME Specific Peptides for FKBP5 Gene


Post-translational modifications for FKBP5 Gene

  • Ubiquitination at Lys 352 and Lys 376
  • Modification sites at PhosphoSitePlus

Other Protein References for FKBP5 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FKBP5 (FKBP5)
  • Cloud-Clone Corp. Antibodies for FKBP5
  • Santa Cruz Biotechnology (SCBT) Antibodies for FKBP5

Domains & Families for FKBP5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 PPIase FKBP-type domains.
  • Contains 3 TPR repeats.
  • Contains 2 PPIase FKBP-type domains.
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with FKBP5: view

Function for FKBP5 Gene

Molecular function for FKBP5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by FK506 but not cyclosporin.
UniProtKB/Swiss-Prot Function:
Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded.
UniProtKB/Swiss-Prot Induction:
By androgen.

Enzyme Numbers (IUBMB) for FKBP5 Gene

Gene Ontology (GO) - Molecular Function for FKBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IDA 11350175
GO:0005515 protein binding IPI 14676191
GO:0005528 FK506 binding IEA,TAS --
GO:0016853 isomerase activity IEA --
GO:0031072 heat shock protein binding IPI 9660753
genes like me logo Genes that share ontologies with FKBP5: view
genes like me logo Genes that share phenotypes with FKBP5: view

Animal Models for FKBP5 Gene

MGI Knock Outs for FKBP5:

Animal Model Products

  • Taconic Biosciences Mouse Models for FKBP5

miRNA for FKBP5 Gene

miRTarBase miRNAs that target FKBP5

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FKBP5 Gene

Localization for FKBP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP5 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FKBP5 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for FKBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005789 endoplasmic reticulum membrane IBA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with FKBP5: view

Pathways & Interactions for FKBP5 Gene

genes like me logo Genes that share pathways with FKBP5: view

Pathways by source for FKBP5 Gene

1 Cell Signaling Technology pathway for FKBP5 Gene
1 BioSystems pathway for FKBP5 Gene
1 KEGG pathway for FKBP5 Gene

Gene Ontology (GO) - Biological Process for FKBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0006457 protein folding TAS 9001212
GO:0061077 chaperone-mediated protein folding IDA 11350175
genes like me logo Genes that share ontologies with FKBP5: view

No data available for SIGNOR curated interactions for FKBP5 Gene

Drugs & Compounds for FKBP5 Gene

(22) Drugs for FKBP5 Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Progesterone Approved, Vet_approved Pharma Full agonist, Activator Endogenous progesterone receptor agonist 537
Citalopram Approved Pharma 503
Clomipramine Approved, Vet_approved Pharma 24
Clozapine Approved Pharma Antagonist Antipsychotic medication 114
Escitalopram Approved, Investigational Pharma 0

(3) Additional Compounds for FKBP5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FKBP5: view

Transcripts for FKBP5 Gene

Unigene Clusters for FKBP5 Gene

FK506 binding protein 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^
SP1: - - - - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - -
SP4: - -
SP5: -
SP6: - - - -
SP7: -

ExUns: 20a · 20b

Relevant External Links for FKBP5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FKBP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FKBP5 Gene

mRNA differential expression in normal tissues according to GTEx for FKBP5 Gene

This gene is overexpressed in Muscle - Skeletal (x8.8) and Whole Blood (x4.0).

Protein differential expression in normal tissues from HIPED for FKBP5 Gene

This gene is overexpressed in Lymph node (18.1) and Peripheral blood mononuclear cells (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FKBP5 Gene

Protein tissue co-expression partners for FKBP5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FKBP5 Gene:


SOURCE GeneReport for Unigene cluster for FKBP5 Gene:


mRNA Expression by UniProt/SwissProt for FKBP5 Gene:

Tissue specificity: Widely expressed, enriched in testis compared to other tissues.
genes like me logo Genes that share expression patterns with FKBP5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FKBP5 Gene

Orthologs for FKBP5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FKBP5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FKBP5 34 35
  • 99.93 (n)
(Bos Taurus)
Mammalia FKBP5 34 35
  • 93.07 (n)
(Canis familiaris)
Mammalia FKBP5 34 35
  • 92.4 (n)
(Monodelphis domestica)
Mammalia FKBP5 35
  • 88 (a)
(Rattus norvegicus)
Mammalia Fkbp5 34
  • 86.26 (n)
(Mus musculus)
Mammalia Fkbp5 34 16 35
  • 84.58 (n)
(Ornithorhynchus anatinus)
Mammalia oan-mir-7424 35
  • 79 (a)
(Gallus gallus)
Aves FKBP51 35
  • 84 (a)
FKBP5 34
  • 76.39 (n)
(Anolis carolinensis)
Reptilia FKBP5 35
  • 81 (a)
(Danio rerio)
Actinopterygii fkbp5 34 35
  • 63.82 (n)
fruit fly
(Drosophila melanogaster)
Insecta FKBP59 36 35
  • 41 (a)
(Caenorhabditis elegans)
Secernentea fkb-6 36 35
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPR1 35
  • 43 (a)
FPR3 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 51 (a)
Species where no ortholog for FKBP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FKBP5 Gene

Gene Tree for FKBP5 (if available)
Gene Tree for FKBP5 (if available)

Paralogs for FKBP5 Gene

Paralogs for FKBP5 Gene

(6) SIMAP similar genes for FKBP5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FKBP5: view

Variants for FKBP5 Gene

Sequence variations from dbSNP and Humsavar for FKBP5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs4713916 drug-response 35,702,206(+) CCTCT(A/G)TTGCA intron-variant
rs1003999 -- 35,576,604(-) GCAGC(C/T)TTGAC intron-variant
rs1043805 -- 35,573,655(-) TTTTT(A/T)AAAAA intron-variant, utr-variant-3-prime
rs10456431 -- 35,652,850(+) gtggc(C/T)tgtgg intron-variant
rs10456432 -- 35,703,874(+) tggca(C/T)tggtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FKBP5 Gene

Variant ID Type Subtype PubMed ID
nsv514355 CNV loss 21397061
nsv517211 CNV gain 19592680
nsv5258 CNV deletion 18451855
nsv602923 CNV gain 21841781
nsv602924 CNV gain 21841781
nsv602927 CNV gain+loss 21841781
nsv7379 OTHER inversion 18451855
nsv7889 CNV gain 18304495
nsv7890 CNV gain 18304495
nsv818412 CNV gain 17921354
nsv820606 CNV deletion 20802225
nsv821646 CNV loss 15273396
nsv958376 CNV deletion 24416366
nsv965719 CNV duplication 23825009
nsv512875 CNV insertion 21212237
nsv511880 CNV loss 21212237
nsv511349 CNV loss 21212237
nsv508403 CNV deletion 20534489
nsv499295 CNV loss 21111241
nsv478643 CNV novel sequence insertion 20440878
nsv470813 CNV gain 18288195
nsv462913 CNV gain 19166990
nsv441992 CNV gain 18776908
nsv428143 CNV gain 18775914
nsv1142008 OTHER inversion 24896259
nsv1128227 CNV deletion 24896259
nsv1072667 CNV deletion 25765185
nsv1028947 CNV gain 25217958
esv987803 CNV deletion 20482838
esv7205 CNV gain 19470904
esv6703 CNV loss 19470904
esv5263 CNV loss 18987735
esv3890842 CNV gain 25118596
esv3608690 CNV gain 21293372
esv3608689 CNV gain 21293372
esv3608688 CNV loss 21293372
esv3608684 CNV loss 21293372
esv3608680 CNV gain 21293372
esv3567631 CNV deletion 23714750
esv3567630 CNV deletion 23714750
esv29881 CNV loss 19812545
esv2761067 CNV gain 21179565
esv2759420 CNV gain 17122850
esv2731913 CNV deletion 23290073
esv2731912 CNV deletion 23290073
esv2731911 CNV deletion 23290073
esv2669578 CNV deletion 23128226
esv2603863 CNV deletion 19546169
esv25611 CNV gain 19812545
esv2421382 CNV duplication 20811451
esv2169093 CNV deletion 18987734
esv1964718 CNV deletion 18987734
esv1362467 CNV deletion 17803354
esv1163117 CNV insertion 17803354
dgv751n27 CNV gain 19166990
dgv5957n100 CNV gain 25217958
dgv5956n100 CNV gain 25217958
dgv26e209 CNV deletion 24192839
dgv178n73 CNV deletion 24416366
dgv1176e214 CNV gain 21293372
dgv10629n54 CNV loss 21841781
dgv10628n54 CNV loss 21841781
dgv10627n54 CNV gain 21841781
dgv10626n54 CNV gain 21841781

Variation tolerance for FKBP5 Gene

Residual Variation Intolerance Score: 40.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FKBP5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FKBP5 Gene

Disorders for FKBP5 Gene

MalaCards: The human disease database

(7) MalaCards diseases for FKBP5 Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
major depressive disorder and accelerated response to antidepressant drug treatment
  • unipolar depression
post-traumatic stress disorder
  • traumatic neurosis
glucocorticoid resistance
  • glucocorticoid resistance, generalized
ocular hypertension
  • agnogenic myeloid metaplasia
- elite association - COSMIC cancer census association via MalaCards
Search FKBP5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FKBP5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FKBP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FKBP5 Gene

Publications for FKBP5 Gene

  1. Assessment of SNPs associated with the human glucocorticoid receptor in primary open-angle glaucoma and steroid responders. (PMID: 20376328) Fingert J.H. … Clark A.F. (Mol. Vis. 2010) 3 22 46 64
  2. Differential expression of immunophilins FKBP51 and FKBP52 in the frontal cortex of HIV-infected patients with major depressive disorder. (PMID: 19199039) Tatro E.T. … Achim C.L. (J Neuroimmune Pharmacol 2009) 3 22 46 64
  3. The FKBP5-gene in depression and treatment response--an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Cohort. (PMID: 18191112) Lekman M. … Paddock S. (Biol. Psychiatry 2008) 3 22 46 64
  4. Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. (PMID: 18349090) Binder E.B. … Ressler K.J. (JAMA 2008) 3 22 46 64
  5. Genetic variants in FKBP5 affecting response to antidepressant drug treatment. (PMID: 18597649) Kirchheiner J. … BrockmAPller J. (Pharmacogenomics 2008) 3 22 46 64

Products for FKBP5 Gene

Sources for FKBP5 Gene

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