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FKBP5 Gene

protein-coding   GIFtS: 68
GCID: GC06M035541

FK506 Binding Protein 5

(Previous name: FK506-binding protein 5)
  See FKBP5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FK506 Binding Protein 51 2     PPIase FKBP52 3
FKBP512 3 5     EC 5.2.1.83 8
FK506-Binding Protein 51 3     P542
Androgen-Regulated Protein 62 3     PPIase2
51 KDa FK506-Binding Protein2 3     Ptg-102
51 KDa FKBP2 3     Peptidyl-Prolyl Cis-Trans Isomerase FKBP52
54 KDa Progesterone Receptor-Associated Immunophilin2 3     Peptidylprolyl Cis-Trans Isomerase2
AIG62 3     rotamase2
FKBP-512 3     T-Cell FK506-Binding Protein2
FKBP542 3     FKBP-53
FF1 Antigen2 3     Rotamase3
HSP90-Binding Immunophilin2 3     p543

External Ids:    HGNC: 37211   Entrez Gene: 22892   Ensembl: ENSG000000960607   OMIM: 6026235   UniProtKB: Q134513   

Export aliases for FKBP5 gene to outside databases

Previous GC identifers: GC06M035543 GC06M035588 GC06M035649 GC06M035262


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FKBP5 Gene:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in
immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is
a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate
calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor
complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple
polyadenylation sites. Alternative splicing results in multiple transcript variants.(provided by RefSeq, Mar
2009)

GeneCards Summary for FKBP5 Gene:
FKBP5 (FK506 binding protein 5) is a protein-coding gene. Diseases associated with FKBP5 include major depressive disorder and accelerated response to antidepressant drug treatment, and major depressive disorder. GO annotations related to this gene include FK506 binding and peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is FKBP1A.

UniProtKB/Swiss-Prot: FKBP5_HUMAN, Q13451
Function: Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors
heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular
trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm
when unliganded

Gene Wiki entry for FKBP5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the FKBP5 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   HNF-3beta   E2F-1   E2F   SEF-1 (1)   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): FKBP5 promoter sequence
   Search Chromatin IP Primers for FKBP5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FKBP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.31   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21.31

FKBP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FKBP5 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M035541:  view genomic region     (about GC identifiers)

Start:
35,541,362 bp from pter      End:
35,696,360 bp from pter
Size:
154,999 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FKBP5_HUMAN, Q13451 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase FKBP5  
Size: 457 amino acids; 51212 Da
Subunit: Part of a heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B and steroid receptors. Upon
ligand binding dissociates from the complex and FKBP4 takes its place. Interacts with functionally mature
heterooligomeric progesterone receptor complexes along with HSP90 and TEBP
Sequence caution: Sequence=BAD93130.1; Type=Frameshift; Positions=29;
Selected PDB 3D structures from and Proteopedia for FKBP5 (see all 27):
1KT0 (3D)        3O5D (3D)        3O5E (3D)        3O5F (3D)        3O5G (3D)        3O5I (3D)    
Secondary accessions: F5H7R1 Q59EB8 Q5TGM6
Alternative splicing: 2 isoforms:  Q13451-1   Q13451-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FKBP5: NX_Q13451

Explore proteomics data for FKBP5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys352, Lys376
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for FKBP5 (Q13451) (see all 14)
     KIVSWLE  ETPMIGD  EQGEDIT  GKKFDSS 


    See FKBP5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001139247.1  NP_001139248.1  NP_001139249.1  NP_004108.1  

    ENSEMBL proteins: 
     ENSP00000349811   ENSP00000444810   ENSP00000441205   ENSP00000445412   ENSP00000442340  

    FKBP5 Human Recombinant Protein Products:

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    OriGene MassSpec for FKBP5
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    Novus Biologicals FKBP5 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FKBP5

     
    Search eBioscience for Proteins for FKBP5 

    FKBP5 Antibody Products:

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    R&D Systems Antibodies for FKBP5 (FKBP51)
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    Abcam antibodies for FKBP5 (Q13451, Q2TA84, Q5TGM6)
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    Search eBioscience for ELISAs for FKBP5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TTC: Tetratricopeptide (TTC) repeat domain containing

    Selected InterPro protein domains (see all 7):
     IPR011990 TPR-like_helical
     IPR023114 Elongated_TPR_rpt_dom
     IPR023566 PPIase_FKBP
     IPR001440 TPR_1
     IPR001179 PPIase_FKBP_dom

    Graphical View of Domain Structure for InterPro Entry Q13451

    ProtoNet protein and cluster: Q13451

    UniProtKB/Swiss-Prot: FKBP5_HUMAN, Q13451
    Similarity: Contains 2 PPIase FKBP-type domains
    Similarity: Contains 3 TPR repeats


    Find genes that share domains with FKBP5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FKBP5_HUMAN, Q13451
    Function: Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors
    heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular
    trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm
    when unliganded
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)
    Enzyme regulation: Inhibited by FK506 but not cyclosporin
    Induction: By androgen

         Enzyme Number (IUBMB): EC 5.2.1.81 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity IDA11350175
    GO:0005515protein binding ----
    GO:0005528FK506 binding IBA--
    GO:0031072heat shock protein binding IPI9660753
         
    Find genes that share ontologies with FKBP5           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FKBP5:
     Increased cell number in S and 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Fkbp5):
     behavior/neurological  homeostasis/metabolism  mortality/aging  normal  renal/urinary system 
     reproductive system 

    Find genes that share phenotypes with FKBP5           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FKBP5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FKBP5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FKBP5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FKBP5

    miRNA
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    miRTarBase miRNAs that target FKBP5:
    hsa-mir-328-3p (MIRT043776), hsa-mir-21-5p (MIRT030843), hsa-mir-22-3p (MIRT050456), hsa-mir-93-3p (MIRT038745)

    Block miRNA regulation of human, mouse, rat FKBP5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FKBP5 (see all 64):
    hsa-miR-194* hsa-miR-140-5p hsa-miR-640 hsa-miR-642a hsa-miR-300 hsa-miR-15a hsa-miR-134 hsa-miR-200a
    SwitchGear 3'UTR luciferase reporter plasmidFKBP5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FKBP5

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 4): FKBP5 (NM_004117)
    Sino Biological Human cDNA Clone for FKBP5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FKBP5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FKBP5

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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-13182) for FKBP5 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FKBP5_HUMAN, Q13451: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0016020membrane IBA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with FKBP5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FKBP5 About    
    See pathways by source

    SuperPathContained pathways About
    1Development Endothelin 1 EDNRA signaling
    Estrogen signaling pathway0.34
    2Prostate Cancer
    Prostate Cancer0.32
    3TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    4PI3K / Akt Signaling
    PI3K / Akt Signaling
    5Glucocorticoid receptor regulatory network
    Glucocorticoid receptor regulatory network


    Find genes that share SuperPaths with FKBP5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for FKBP5
        PI3K / Akt Signaling

    3 BioSystems Pathways for FKBP5
        TNF-alpha/NF-kB Signaling Pathway
    Prostate Cancer
    Glucocorticoid receptor regulatory network



    1 Kegg Pathway  (Kegg details for FKBP5):
        Estrogen signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FKBP5
    Interactions:

        GeneGlobe Interaction Network for FKBP5

    Selected Interacting proteins for FKBP5 (Q134512, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IKBKEQ141642, 3MINT-47961 MINT-48123 I2D: score=5 
    CHUKO151112, 3MINT-47952 MINT-48060 I2D: score=4 
    MAP3K1Q132332, 3MINT-48346 MINT-47977 I2D: score=3 
    MAP3K7O433182MINT-48031 MINT-49248
    HSP90AA1P079003I2D: score=4 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000413protein peptidyl-prolyl isomerization IDA11350175
    GO:0006457protein folding TAS9001212
    GO:0018208peptidyl-proline modification IBA--
    GO:0061077chaperone-mediated protein folding IDA11350175

    Find genes that share ontologies with FKBP5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FKBP5

    1 HMDB Compound for FKBP5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Progesterone17a-Progesterone (see all 114)57-83-0--

    Selected Novoseek inferred chemical compound relationships for FKBP5 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tacrolimus 74.5 33 18326728 (3), 20023700 (3), 7693698 (3), 15089760 (2) (see all 19)
    steroid 60.9 12 11751894 (2), 1383226 (1), 15821585 (1), 20371398 (1) (see all 10)
    rapamycin 58.6 22 9658403 (3), 15878982 (2), 11089542 (1), 18320068 (1)
    molybdate 48.5 2 2303491 (1), 9183567 (1)
    progestin 48.2 9 12746298 (7)
    dexamethasone 47.8 18 18326728 (4), 11089542 (2), 12519866 (2), 16723223 (1) (see all 7)
    mifepristone 46.2 2 20371398 (1), 12746298 (1)
    cyclosporin a 42.8 8 20023700 (3), 11089542 (1), 12351405 (1), 12611898 (1)
    progesterone 41.7 8 7688746 (3), 8114727 (1), 7693698 (1), 9195978 (1) (see all 6)
    testosterone 36.5 18 20023700 (4), 15821585 (3), 19433513 (3), 12917209 (1) (see all 7)

    Selected PharmGKB related drug/compound annotations for FKBP5 gene (see all 12)    About this table
    Drug/compound PharmGKB Annotation
    Selective serotonin reuptake inhibitorsCA  
    antidepressantsCA  
    citalopramCA  
    clomipramineCA  
    corticosteroidsCA  
    escitalopramCA  
    fluoxetineCA  
    lithiumCA  
    mirtazapineCA  
    nefazodoneCA  



    Find genes that share compounds with FKBP5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FKBP5 gene (4 alternative transcripts): 
    NM_001145775.2  NM_001145776.1  NM_001145777.1  NM_004117.3  

    Unigene Cluster for FKBP5:

    FK506 binding protein 5
    Hs.407190  [show with all ESTs]
    Unigene Representative Sequence: NM_001145777
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357266(uc003okx.2 uc011dtf.1) ENST00000536438(uc003oky.2)
    ENST00000539068(uc011dte.1) ENST00000540787 ENST00000542713(uc003okz.2)

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    Selected qRT-PCR Assays for microRNAs that regulate FKBP5 (see all 64):
    hsa-miR-194* hsa-miR-140-5p hsa-miR-640 hsa-miR-642a hsa-miR-300 hsa-miR-15a hsa-miR-134 hsa-miR-200a
    SwitchGear 3'UTR luciferase reporter plasmidFKBP5 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB209893.1 AF194172.1 AK093304.1 AK222807.1 AK302704.1 AK303356.1 AK312422.1 AL122066.1 
    BC034770.1 BC042605.1 BC111050.1 BX647390.1 HM245387.1 HM245388.1 HM245391.1 NR_027117.1 
    U42031.1 U71321.1 X97300.1 

    18 DOTS entries:

    DT.100810577  DT.217993  DT.100810576  DT.100036440  DT.100000254  DT.100810580  DT.91638670  DT.100801419 
    DT.121339202  DT.95200204  DT.121339196  DT.121339223  DT.121339249  DT.75120548  DT.95136421  DT.100755214 
    DT.121339167  DT.121339252 

    Selected AceView cDNA sequences (see all 336):

    AA345703 BQ014697 BP377824 BM705679 AA789188 AL046952 X97300 AJ715015 
    AI679222 CD558819 AL045832 BP376819 AA366751 CB852121 CR620368 AI366055 
    AF194172 BC042605 BX364564 AI220884 AA360668 AW082272 BP338993 BP378260 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FKBP5 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^
    SP1:                    -     -           -     -     -     -     -     -     -     -                                                     -                     
    SP2:                                                        -     -     -     -     -                                                     -                     
    SP3:                          -           -     -     -     -     -     -     -     -                                                                           
    SP4:                                                        -     -                                                                                             
    SP5:                    -                                                                                                                                       

    ExUns: 20a · 20b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for FKBP5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FKBP5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTCCAGTGA
    FKBP5 Expression
    About this image


    FKBP5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    FKBP5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FKBP5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.407190

    UniProtKB/Swiss-Prot: FKBP5_HUMAN, Q13451
    Tissue specificity: Widely expressed, enriched in testis compared to other tissues

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FKBP5 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fkbp51 , 5 FK506 binding protein 51, 5 84.58(n)1
    87.28(a)1
      17 (14.66 cM)5
    142291  NM_010220.41  NP_034350.11 
     283990955 
    chicken
    (Gallus gallus)
    Aves FKBP51 FK506 binding protein 5 76.39(n)
    84.19(a)
      421186  NM_001005431.1  NP_001005431.1 
    lizard
    (Anolis carolinensis)
    Reptilia FKBP56
    FK506 binding protein 5
    81(a)
    1 ↔ 1
    GL343382.1(891540-916270)
    zebrafish
    (Danio rerio)
    Actinopterygii fkbp51 FK506 binding protein 5 63.82(n)
    62.56(a)
      368924  NM_213149.1  NP_998314.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta FKBP593 peripheral nervous system development
    FK506 binding
    41(a)   30E1   --
    worm
    (Caenorhabditis elegans)
    Secernentea fkb-63 FKBP-type peptidyl-prolyl cis-trans
    isomerases
    41(a)   V(20838115-20839280)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FPR3(YML074C)4 Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); more   --   13(121324-120089) 854901  NP_013637.1 


    ENSEMBL Gene Tree for FKBP5 (if available)
    TreeFam Gene Tree for FKBP5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FKBP5 gene
    FKBP1A2  FKBP1C2  FKBP42  FKBP82  FKBP62  FKBP1B2  FKBP32  
    6 SIMAP similar genes for FKBP5 using alignment to 5 protein entries:     FKBP5_HUMAN (see all proteins):
    FKBP4    FKBP12-Exip2    FKBP1B    FKBP1A    FKBP1C    FKBP2

    Find genes that share paralogs with FKBP5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FKBP5 (see all 2872)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs94700631,2
    C,F,H--35540868(+) AGCAAT/CGATGC 3 -- int127Minor allele frequency- C:0.18NS EA NA WA CSA 2490
    rs1380445581,2
    --35540881(+) TGTTCC/TGCCAC 3 -- int10--------
    rs1458514391,2
    --35540958(+) ATTTT-/CTGA  
            
    TTTTT
    3 -- int10--------
    rs601165431,2
    C--35540985(+) TTTTT-/TT/T  
     TT
    /TTTT
    GAGAC
    6 -- int1 cds11NA 2
    rs1931266561,2
    --35540994(+) ACCAAA/GTCTCA 3 -- int10--------
    rs120554381,2
    C,F,A--35541058(+) CTTCCT/CAGGTT 3 -- int17Minor allele frequency- C:0.14NA WA CSA 14
    rs1848420621,2
    --35541141(+) TTGTAG/TTTTTA 3 -- int10--------
    rs1471510521,2
    C--35541157(+) GACAGC/GGTTTT 3 -- int10--------
    rs1161785511,2
    F--35541257(+) CACTAC/TGCCTG 3 -- int11Minor allele frequency- T:0.01WA 118
    rs1181779141,2
    F--35541258(+) ACTACG/ACCTGA 3 -- int11Minor allele frequency- A:0.03EA 120

    HapMap Linkage Disequilibrium report for FKBP5 (35541362 - 35696360 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FKBP5 (see all 40):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1964718CNV Deletion18987734
    esv2169093CNV Deletion18987734
    esv1362467CNV Deletion17803354
    esv2731911CNV Deletion23290073
    esv987803CNV Deletion20482838
    esv2669578CNV Deletion23128226
    esv2603863CNV Deletion19546169
    esv2731912CNV Deletion23290073
    esv2731913CNV Deletion23290073
    esv5263CNV Deletion18987735

    Human Gene Mutation Database (HGMD): FKBP5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FKBP5
    DNA2.0 Custom Variant and Variant Library Synthesis for FKBP5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602623   
    OMIM disorders: 608516  
    5 diseases for FKBP5:    
    About MalaCards
    major depressive disorder and accelerated response to antidepressant drug treatment    major depressive disorder    glucocorticoid resistance    post-traumatic stress disorder
    myelofibrosis


    Find genes that share disorders with FKBP5           About GenesLikeMe

    6 Novoseek inferred disease relationships for FKBP5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    idiopathic myelofibrosis 66.9 4 15089760 (2), 12842707 (1), 12351405 (1)
    shock 37.4 7 15802496 (2), 10022435 (1), 11525247 (1), 9658403 (1) (see all 5)
    prostate cancer 30.8 7 15131019 (3), 15821585 (1), 20023700 (1)
    mammary tumor 19.4 2 12746298 (1)
    tumors 0 4 15131019 (2), 18320068 (1)
    cancer 0 4 19732725 (4)

    Genetic Association Database (GAD): FKBP5
    Human Genome Epidemiology (HuGE) Navigator: FKBP5 (29 documents)

    Export disorders for FKBP5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FKBP5 gene, integrated from 10 sources (see all 204):
    (articles sorted by number of sources associating them with FKBP5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor. (PubMed id 9001212)1, 2, 3 Nair S.C.... Smith D.F. (Mol. Cell. Biol. 1997)
    2. Differential expression of immunophilins FKBP51 and FKBP52 in the frontal cortex of HIV-infected patients with major depressive disorder. (PubMed id 19199039)1, 4, 9 Tatro E.T....Achim C.L. (J Neuroimmune Pharmacol 2009)
    3. Tissue distribution and abundance of human FKBP51, an FK506-binding protein that can mediate calcineurin inhibition. (PubMed id 9125197)1, 2, 9 Baughman G.... Bourgeois S. (Biochem. Biophys. Res. Commun. 1997)
    4. Genetic variants in FKBP5 affecting response to antidepressant drug treatment. (PubMed id 18597649)1, 4, 9 Kirchheiner J....BrockmAPller J. (Pharmacogenomics 2008)
    5. FKBP54, a novel FK506-binding protein in avian progesterone receptor complexes and HeLa extracts. (PubMed id 7693698)1, 2, 9 Smith D.F.... Deibel M.R. Jr. (J. Biol. Chem. 1993)
    6. Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. (PubMed id 18349090)1, 4, 9 Binder E.B....Ressler K.J. (JAMA 2008)
    7. The FKBP5-gene in depression and treatment response--an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Cohort. (PubMed id 18191112)1, 4, 9 Lekman M....Paddock S. (Biol. Psychiatry 2008)
    8. Assessment of SNPs associated with the human glucocorticoid receptor in primary open-angle glaucoma and steroid responders. (PubMed id 20376328)1, 4, 9 Fingert J.H....Clark A.F. (Mol. Vis. 2010)
    9. Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up. (PubMed id 21041608)1, 4 van Winkel R. (Arch. Gen. Psychiatry 2011)
    10. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (J Psychiatr Res 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2289 HGNC: 3721 AceView: FKBP5 Ensembl:ENSG00000096060 euGenes: HUgn2289
    ECgene: FKBP5 Kegg: 2289 H-InvDB: FKBP5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FKBP5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FKBP5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FKBP5 gene:
    Search GeneIP for patents involving FKBP5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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