Show Advanced Search
""
""

Advanced Search (alpha)

""
 
Search By
Section
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS
Search by expression pattern


FKBP5 Gene

protein-coding   GIFtS: 64

GC06M035541
FK506 binding protein 5
(Previous name: FK506-binding protein 5 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
"" "" "" "" "" "" "" "" "" "" "" "" "" "" "" ""Services    
 "" "" "" "" "" "" "" "" "" "" "" "" ""

Aliases &
Descriptions
for FKBP5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

  User Feedback
Aliases & Descriptions
FK506 binding protein 51 2     FKBP-52 3
FKBP511 2 3 5     FF1 antigen2 3
FKBP541 2 3     54 kDa progesterone receptor-associated immunophilin2 3
P541 2     51 kDa FK506-binding protein 52
PPIase1 2     peptidylprolyl cis-trans isomerase2
Ptg-101 2     peptidyl-prolyl cis-trans isomerase FKBP52
FK506-binding protein 51 3     MGC1110062
Androgen-regulated protein 62 3     rotamase2
FKBP-512 3     T-cell FK506-binding protein2
HSP90-binding immunophilin2 3     51 kDa FK506-binding protein3
AIG62 3     EC 5.2.1.83
51 kDa FKBP2 3     p543
PPIase FKBP52 3     Rotamase3

External Ids:    HGNC: 37211   Entrez Gene: 22892   Ensembl: ENSG000000960607   UniProtKB: Q134513   

Search outside databases for aliases for FKBP5 gene

Previous GC identifers: GC06M035543 GC06M035588 GC06M035649

Summaries
for FKBP5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  User Feedback		 Entrez Gene summary for FKBP5:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation
and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl
isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition.
It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa
heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative
splicing results in multiple transcript variants.(provided by RefSeq)

UniProtKB/Swiss-Prot: FKBP5_HUMAN, Q13451
Function: Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP

Genomic Views
for FKBP5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
About This Section

  User Feedback		 Regulatory elements:
"" SABiosciences Regulatory transcription factor binding sites in the FKBP5 gene upstream (promoter) region "":
NF-kappaB1   STAT5A   STAT5B   GR-alpha   GR-beta   NF-kappaB   POU2F2 (Oct-2.1)   Oct-B1   POU2F2C   POU2F1   

Epigenetics:
"" SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for FKBP5:  ""
MePH08895-2A   

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3-p21.2   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21.31

FKBP5 Gene in genomic location: bands according to Ensembl, locations according to "" (and/or Entrez Gene and/or Ensembl if different)
""

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M035541:  view genomic region     (about GC identifiers)

Start:
 35,541,362 bp from pter
End:
 35,696,360 bp from pter
Size:
 154,999 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  

Proteins
for FKBP5 gene

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

  User Feedback		 UniProtKB/Swiss-Prot: FKBP5_HUMAN, Q13451 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase FKBP5  
Size: 457 amino acids; 51212 Da
Subunit: Part of a heteromultimeric cytoplasmic complex with HSP90, HSP70 and steroid receptors. Dissociates from the
complex when NR3C1 binds glucocorticoid
Subcellular location: Cytoplasm. Nucleus
PDB structures from "" and Proteopedia "" :
1KT0 (3D) ""    

Post-translational modifications:

  • Phosphorylated upon DNA damage, probably by ATM or ATR1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (4 alternative transcripts): 
    NP_001139247.1  NP_001139248.1  NP_001139249.1  NP_004108.1  


    ENSEMBL proteins: 
    ENSP00000349811 ENSP00000338160 ENSP00000362982 


    Human Recombinant Proteins 
    ""Browse Purified and Recombinant Proteins at Millipore
    ""Browse Human Recombinant Proteins at Sigma-Aldrich
    "" Browse R&D Systems for human recombinant proteins
    ""Enzo Life Sciences proteins for FKBP5
    ""HuPro® and/or Recombinant Proteins from Abnova for FKBP5 ""
    "" Origene Purified Recombinant Human Protein: FKBP5
    ""Novus Biologicals Proteins for FKBP5  ""
    Novus Biologicals Lysates for FKBP5
    ""Browse Sino Biological Recombinant Proteins  ""

    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm IEA--
    About this table

    "" FKBP5 for ontologies           About GeneDecksing



    Antibodies for FKBP5: 
    ""Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    ""Sigma-Aldrich Antibodies for FKBP5
    ""R&D Systems Antibodies for FKBP5 (FKBP51)
    ""Monoclonal and Polyclonal Antibodies from Abnova (FKBP5)
    ""Browse Origene Antibodies ""
    ""Novus Biologicals Antibodies for FKBP5
    ""Browse antibodies at Epitomics

    Assays for FKBP5: 
    ""Browse Kits and Assays available from Millipore
    ""Browse ELISAs at Sigma-Aldrich
    "" Browse R&D Systems for biochemical assays
    ""Enzo Life Sciences assays for FKBP5

    Protein Domains/
    Families
    for FKBP5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

      User Feedback
    "" FKBP5 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR011990 TPR-like_helical
     IPR001440 TPR-1
     IPR001179 PPIase_FKBP
     IPR013026 TPR-contain
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry Q13451

    ProtoNet protein and cluster: Q13451

    UniProtKB/Swiss-Prot: FKBP5_HUMAN, Q13451
    Similarity: Contains 2 PPIase FKBP-type domains
    Similarity: Contains 3 TPR repeats

    Gene Function
    for FKBP5 gene

    (According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
    About This Section

      User Feedback
    Inhib.
    RNA:    		""Browse for Gene Knock-down Tools from Millipore
    ""Abnova Chimera RNAi Products for Gene knock-down (FKBP5)
    "" Origene 29mer shRNA kits in GFP-retroviral vector (see all 4): FKBP5
    Origene shRNA RFP (see all 4): FKBP5
    Origene basic RS shRNA (see all 4): FKBP5

    ""Applied Biosystems Silencer® siRNAs for FKBP5
    ""Sigma-Aldrich siRNA Panels and siRNA for FKBP5
    Sigma-Aldrich shRNA for FKBP5
    Explore Sigma-Aldrich super-pooled esiRNAs
    Clones:""Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    ""Browse iPSC Reprogramming Factors at Sigma-Aldrich
    "" Origene GFP tagged cDNA clones in CMV expression vector (see all 4): FKBP5
    Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): FKBP5
    Origene untagged cDNA clones in CMV expression vector (see all 4): FKBP5
    ""Sino Biological Human cDNA Clone for FKBP5  ""

    UniProtKB/Swiss-Prot: FKBP5_HUMAN, Q13451
    Function: Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)
    Enzyme regulation: Inhibited by FK506 but not cyclosporin
    Induction: By androgen
    Enzyme Number (IUBMB): EC 5.2.1.8 

    5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA--
    GO:0005515 protein binding IPI14743216
    GO:0005528 FK506 binding TAS9001212
    GO:0016853 isomerase activity IEA--
    GO:0031072 heat shock protein binding IPI9660753
    About this table

    "" FKBP5 for ontologies           About GeneDecksing

    Animal Models: 3 MGI mutant phenotypes (inferred from 2 alleles"") (MGI details for Fkbp5):

    lethality-prenatal/perinatalnormalrenal/urinary system

    "" FKBP5 for phenotypes           About GeneDecksing

    Pathways & Interactions
    for FKBP5 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
    About This Section

      User Feedback
    "" FKBP5 for pathways           About GeneDecksing

    2 "" Sigma-Aldrich "Your Favorite Gene" Pathways for  FKBP5  (Your Favorite Gene powered by Ingenuity)
      ""  Glucocorticoid Receptor Signaling
    NRF2-mediated Oxidative Stress Response

    "" SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FKBP5

    5 Interacting proteins for FKBP5 (Q134511, 2) via UniProtKB, MINT, and/or STRING ""
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHUKO151111, 2EBI-306914,EBI-81249 MINT-47952 MINT-48060 EBI-306914,EBI-81249 MINT-47952 MINT-48060
    IKBKEQ141642MINT-47961 MINT-48123
    MAP3K1Q132332MINT-48346 MINT-47977
    MAP3K7O433182MINT-48031 MINT-49248
    --O394742MINT-2841064
    About this table

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457 protein folding IEA--
    About this table

    "" FKBP5 for ontologies           About GeneDecksing


    Drugs & Compounds
    for FKBP5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

      User Feedback
    "" FKBP5 for compounds           About GeneDecksing

    "" Enzo Life Sciences drugs & compounds for FKBP5
    ""Browse Small Molecules at Sigma-Aldrich

    "" Browse Tocris compounds for FKBP5
    10/35 ""Novoseek chemical compound relationships for FKBP5 gene (see all 35 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    fk506 57.03 42 7693698 (4), 20023700 (3), 18326728 (3), 11813252 (3) (see all 28)
    progesterone 13.84 25 12746298 (8), 9514152 (4), 9001212 (3), 7688746 (3) (see all 10)
    fluticasone propionate 9.03 7 20371398 (7)
    rapamycin 7.45 9 9658403 (3), 15878982 (2), 7542743 (1), 18320068 (1) (see all 6)
    progestins 6.88 5 15544162 (4), 9195978 (1)
    dexamethasone 5.43 12 18326728 (4), 12519866 (2), 11089542 (2), 20093418 (1) (see all 7)
    ascomycin 4.42 2 7542743 (2)
    molybdate 2.72 2 9183567 (1), 2303491 (1)
    cyclosporin a 2.51 8 20023700 (3), 9001212 (1), 7929183 (1), 12611898 (1) (see all 6)
    kn62 2.27 1 9658403 (1)
    About this table


    Transcripts
    for FKBP5 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
    Expression Assays from Applied Biosystems)
    About This Section

      User Feedback
    Inhib.
    RNA:    		""Browse for Gene Knock-down Tools from Millipore
    ""Abnova Chimera RNAi Products for Gene knock-down (FKBP5)
    ""Applied Biosystems Silencer® siRNAs:  NM_001145775  NM_001145776  NM_001145777  NM_004117  
    "" Origene 29mer shRNA kits in GFP-retroviral vector (see all 4): FKBP5
    Origene shRNA RFP (see all 4): FKBP5
    Origene basic RS shRNA (see all 4): FKBP5

    ""Sigma-Aldrich siRNA Panels and siRNA for FKBP5
    Sigma-Aldrich shRNA for FKBP5
    Explore Sigma-Aldrich super-pooled esiRNAs

    microRNA:""6 SABiosciences microRNAs that regulate FKBP5: ""
    hsa-miR-141 hsa-miR-203 hsa-miR-495 hsa-miR-544 hsa-miR-122 hsa-miR-200a
    Assays:  ""Applied Biosystems TaqMan® Gene Expression Assays:  
    NM_001145775  NM_001145776  NM_001145777  NM_004117  


    Clones:"" Origene GFP tagged cDNA clones in CMV expression vector (see all 4): FKBP5
    Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): FKBP5
    Origene untagged cDNA clones in CMV expression vector (see all 4): FKBP5
    Primers:"" Origene genome-wide validated SYBR primer pairs: FKBP5
    ""SABiosciences RT2 qPCR Primer Assay for FKBP5: PPH02277A ""

    REFSEQ mRNAs for FKBP5 gene (4 alternative transcripts): 

    NM_001145775.1  NM_001145776.1  NM_001145777.1  NM_004117.3  

    Additional cDNA sequence: 

    AB209893.1 AF194172.1 AK093304.1 AK222807.1 AK302704.1 AK303356.1 AK312422.1 AL122066.1 
    BC034770.1 BC042605.1 BC111050.1 BX647390.1 CR620368.1 U42031.1 U71321.1 X97300.1 

    18 DOTS entries:

    DT.100810577  DT.217993  DT.100810576  DT.100036440  DT.100000254  DT.100810580  DT.91638670  DT.100801419 
    DT.121339202  DT.40227714  DT.95200204  DT.121339196  DT.121339252  DT.121339167  DT.121339223  DT.75120548 
    DT.95136421  DT.121339249 

    24/336 AceView cDNA sequences (see all 336 ):

    AW082272 AA360668 AI220884 BP338993 BP378260 CB217026 BX364564 BC042605 
    AF194172 AI366055 CR620368 CB852121 AA366751 BP376819 AL045832 CD244775 
    AA767954 BP338879 AI631283 U71321 AL701502 AI700784 AL042081 BM693725 

    "" highest scoring ESTs for FKBP5:

    AA382675 AI753747 AL701450 AL701502 AW500704 BG392941 BG899577 BM546723 BM921807 BX470415 

    Unigene Cluster for FKBP5:

    FK506 binding protein 5
    Hs.407190  [show with all ESTs]
    Unigene Representative Sequence: NM_001145777


    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for FKBP5 (see all 8 )

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^
    SP1:                    -     -           -     -     -     -     -     -     -     -                                                     -                     
    SP2:                                                        -     -     -     -     -                                                     -                     
    SP3:                          -           -     -     -     -     -     -     -     -                                                                           
    SP4:                                                        -     -                                                                                             
    SP5:                    -                                                                                                                                       

    ExUns: 20a · 20b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            

    About this scheme

    ECgene alternative splicing isoforms for FKBP5

    3 Ensembl transcripts including schematic representations:
    ENST00000357266  ENST00000337746  ENST00000373875  

    Expression
    for FKBP5 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
    About This Section

      User Feedback

    FKBP5 expression in normal and diseased human tissues

    "" Applied Biosystems TaqMan ® Gene Expression Assays for FKBP5

    1""  / 2""  / 3""

    8 probe-sets matching FKBP5 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    46271_at2, 3 U95-B 1 1.00 1.00 0.99 1.16 AI753747 0.80 1.00 0.91 1
    34721_at2, 3 U95-A 1 1.00 1.00 0.98 0.84 U42031 0.80 0.80 0.80 1
    204560_at2, 3 U133-A 1 1.00 1.00 -- -- NM_004117 0.60 1.00 0.82 1
    224856_at2, 3 U133-B 1 1.00 1.00 -- -- W86302 0.40 1.00 0.76 1
    224840_at2, 3 U133-B 1 1.00 1.00 -- -- AI753747 0.80 1.00 0.91 1
    204560_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    224856_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    224840_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    "" FKBP5 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GTTCCAGTGA

    SOURCE GeneReport for Unigene cluster: Hs.407190

    Expression variation in blood from EXPOLDB for FKBP5

    UniProtKB/Swiss-Prot: FKBP5_HUMAN, Q13451
    Tissue specificity: Widely expressed, enriched in testis compared to other tissues

    Primers:"" Origene genome-wide validated SYBR primer pairs: FKBP5 ""
    ""SABiosciences RT2 qPCR Primer Assay for FKBP5: PPH02277A ""

    Orthologs
    for FKBP5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

      User Feedback
    Orthologs for FKBP5 gene from 5/13 species (see all 13 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 FKBP51   -- FK506 binding protein 5 92.4(n)
    95.39(a)    		 481759  XM_538880.2  XP_538880.2 
    chimpanzee
    (Pan troglodytes)    		 FKBP51   -- FK506 binding protein 5 99.93(n)
    99.78(a)    		 462639  XM_001172411.1  XP_001172411.1 
    cow
    (Bos taurus)    		 FKBP51   -- FK506 binding protein 5 93.8(n)
    97.18(a)    		 535704  XM_615814.3  XP_615814.3 
    rat
    (Rattus norvegicus)    		 Fkbp51   -- FK506 binding protein 5 86.26(n)
    91.45(a)    		 361810  NM_001012174.1  NP_001012174.1 
    mouse
    (Mus musculus)    		 Fkbp51, 5 17 (13.00 cM)5
    		 FK506 binding protein 51, 5 84.58(n)1
    87.28(a)1    		 142291  NM_010220.21  NP_034350.11 
     AK0041755  AK1593895  (see all 19)
    About this table        Species with no ortholog for FKBP5

    ENSEMBL Gene Tree for FKBP5

    Paralogs
    for FKBP5 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      User Feedback
    Paralogs for FKBP5 gene
    FKBP1A2  FKBP1C2  FKBP42  FKBP62  FKBP1B2  FKBP32  

    "" FKBP5 for paralogs           About GeneDecksing


    Genomic Variants
    for FKBP5 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
    About This Section

      User Feedback
    10/684 NCBI SNPs in FKBP5 are shown (see all 684 )
    (Click "" for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 146)
    ABGenomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    --
    rs93805261,2
    		C,F,A,H35375536(+) tgtctC/Tagtca 4 -- ng51 int1""10Minor allele frequency- T:0.43NS EA NA WA 636""
    ""
    rs77570371,2
    		C,F,A,H35268878(+) CATCCA/GTCCCT 4 -- int1 ng31""19Minor allele frequency- G:0.49NS EA NA WA 1378""
    ""
    rs28170351,2
    		C,F,A,H35414148(+) TCTGGG/AGTAGT 1 -- ng51""6Minor allele frequency- A:0.20NA EA 522""
    ""
    rs27665371,2
    		C,F,A,H35414671(+) GGTTCC/TGGGAA 1 -- ng51 tfbs3""5Minor allele frequency- T:0.44EA NA WA 390""
    ""
    rs38003731,2
    		C,F,A,H35542476(-) TGTAGT/GGTTGA 3 -- ut31 ese3""10Minor allele frequency- G:0.30EA NA WA 432""
    --
    rs10438051,2
    		C,F,A35541432(-) TTTTTT/AAAAAA 3 -- ut31 trp3""9Minor allele frequency- A:0.18NS EA NA WA 630""
    --
    rs93688851,2
    		C,A,H35375853(+) CAGGCG/ATGGTG 4 -- ng51 int1""2Minor allele frequency- A:0.00NA 4""
    ""
    rs28170341,2
    		C,H35696289(+) CCCCTC/TTGGGA 1 -- ut51 ese3""3Minor allele frequency- T:0.00NA 6""
    --
    rs94700631,2
    		C,F35261506(+) AGCAAT/CGATGC 3 -- ng31""12Minor allele frequency- C:0.18NS EA NA WA 762""
    --
    rs115459251,2
    		C,F35542526(-) AAAAAA/TATTTT 3 -- ut31""1Minor allele frequency- T:0.12NA 72""
    About this table

    HapMap Linkage Disequilibrium images for FKBP5 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)  ""
    Database of Genomic Variants (DGV): 29 variations for FKBP5
         15/25 CNVs (see all 25 ): 36516 51903 51906 31284 43539 81370 81368 44255 37752 31283 99504 93672 64485 81369 53613
         3 Indels: 93673 69487 60588
         1 Inversion: 37274

    Disorders & Mutations
    for FKBP5 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      User Feedback
    "" FKBP5 for disorders           About GeneDecksing

    OMIM: 602623   disorders: 608516  

    10/40 ""Novoseek disease relationships for FKBP5 gene (see all 40 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    myelofibrosis 22.16 15 15089760 (6), 15833861 (4), 12842707 (3), 12351405 (2)
    glucocorticoid resistance 16.94 7 16723223 (2), 15802496 (1), 12871166 (1), 11703081 (1) (see all 6)
    eosinophilic esophagitis 6.79 4 20371398 (4)
    ptsd 3.27 6 18349090 (6)
    major depression 3.20 6 19199039 (5), 18180755 (1)
    benign prostate tumor 3.18 1 15131019 (1)
    progesterone resistance 2.94 1 12746298 (1)
    colorectal adenocarcinoma 2.53 2 18443959 (2)
    glioma 2.17 5 18320068 (5)
    bipolar disorder 2.10 4 18180755 (3), 19595676 (1)
    About this table

    1 PharmGKB disease relationship for FKBP5 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1FA  GN  12086872 12730115
    About this table

    Human Gene Mutation Database: FKBP5
    Genetic Association Database: FKBP5
    Human Genome Epidemiology Navigator: FKBP5 (22 documents)

    Medical News
    for FKBP5 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      User Feedback    		   --

    Publications
    for FKBP5 gene

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

      User Feedback    		10/132 PubMed articles for FKBP5 gene (see all 132 ):

    Search for FKBP5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

      User Feedback
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FKBP5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

      User Feedback
    Entrez Gene: 2289 HGNC: 3721 AceView: FKBP5 Ensembl:ENSG00000096060 euGenes: HUgn2289
    ECgene: FKBP5 H-InvDB: FKBP5

    Other Databases showing FKBP5 gene

    (According to HUGE)
    About This Section

      User Feedback    		   --

    Specialized Databases showing FKBP5 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      User Feedback
    NameDescription
    ATLAS Chromosomes in Cancer entry for FKBP5 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for FKBP5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section

      User Feedback    		Patent Information for FKBP5 gene: ""
    Search GeneIP for patents involving FKBP5

    GeneCards and IP: ""
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search


    Services
    for FKBP5 gene

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Novus Biologicals,
    Epitomics, Sigma-Aldrich, R&D Systems, SABiosciences, Millipore, Abnova,
    Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section

      User Feedback    		""
    ""
    Products for FKBP5:
    "" TaqMan ® Gene Expression Assays
    "" TaqMan ® Genotyping Assays
    		 "" Free SNP selection tool

    ""
    "" Millipore Custom Antibody & Bulk Services
    "" Millipore Preclinical / Clinical Development Services
    "" Millipore Immunoassay Services
    "" Millipore Target Screening & Profiling Services

    ""
    "" Predesigned and custom siRNAs for FKBP5"" Antibodies for FKBP5
    "" Explore super-pooled esiRNAs"" Browse proteins at Sigma-Aldrich
    "" Lentivirus-delivered shRNAs for FKBP5"" Browse small molecules at Sigma-Aldrich
    "" "Your Favorite Gene" Pathways"" Browse ELISAs at Sigma-Aldrich
    "" Browse iPSC Reprogramming Factors at Sigma-Aldrichfeedback


     ""  ""
    "" Antibodies  "" Primer Pairs  
    "" Cell Culture Products  "" ELISAs  
    "" Flow Cytometry Kits  "" Protease Activity Assays & Reagents  
    "" Cell Selection/Detection Kits & Reagents  "" ELISA/Assay Development Kits & Reagents  
    "" Multiplex/Array Assay Kits & Reagents  "" ELISpot Kits & Development Modules  
    "" Recombinant & Natural Proteins  

    "" Recombinant Proteins (FKBP5)
    "" Antibodies (FKBP5)
    "" Chimera RNAi (FKBP5)
    "" Custom Service for Mouse Mab
    "" Custom Service for Rabbit Pab from Full-length Protein


    """"""""
    "" Search for Antibodies & Assays

    "" Tagged/untagged cDNA clones
    "" Validated SYBR primer pairs
    "" Purified proteins from HEK293T cells
    "" Western blot validated antibodies
    "" shRNA in GFP-retroviral vector
    "" Custom immunoassay development
    "" Search Tocris compounds for FKBP5
    "" Regulatory tfbs in FKBP5 upstream (promoter) region
    "" Search Chromatin IP Primers for FKBP5
    "" DNA Methylation qPCR Primer Assays for FKBP5
    "" RT2 qPCR Primer Assay for FKBP5
    "" GNC Network for FKBP5
    "" microRNAs that regulate FKBP5
    """"""""
    "" Assays/Drugs/Proteins for FKBP5
    "" Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
    "" Novus Tissue Slides
    "" Antibodies for FKBP5
    "" Proteins for FKBP5
    "" Lysates for FKBP5
    "" Browse antibodies at Epitomics
    "" Browse Sino Biological Proteins and Antibodies
    "" cDNA Clones for FKBP5
    "" Antibodies/Proteins Production Services
    "" Rabbit Monoclonal Antibody Platform
    "" Bulk Purchasing
      User Feedback        

    GeneCards Homepage - Last full update: 21 May 2010 - Incremental updates: 24 May 2010 , 20 Jun 2010

    View Random Gene

    Category
    acyl-CoA synthetase family member 3
    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2010 , Weizmann Institute of Science. All Rights Reserved.
    FKBP5 gene at Home site.
    hostname: server4.xennexinc.com db build: 72 index build: 72d solr: 1.4