FKBP5 Gene
protein-coding GIFtS: 66
GCID: GC06M035541
|
|
FK506 binding protein 5(Previous name: FK506-binding protein 5 )
| |
Aliases
for FKBP5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| FK506 Binding Protein 51 2 | | FF1 Antigen2 3 | | FKBP511 2 3 5 | | HSP90-Binding Immunophilin2 3 | | FKBP541 2 3 | | PPIase FKBP52 3 | | P541 2 | | EC 5.2.1.83 8 | | PPIase1 2 | | 51 KDa FK506-Binding Protein 52 | | Ptg-101 2 | | Peptidyl-Prolyl Cis-Trans Isomerase FKBP52 | | FK506-Binding Protein 51 3 | | Peptidylprolyl Cis-Trans Isomerase2 | | Androgen-Regulated Protein 62 3 | | Rotamase3 | | 51 KDa FKBP2 3 | | T-Cell FK506-Binding Protein2 | | 54 KDa Progesterone Receptor-Associated Immunophilin2 3 | | 51 KDa FK506-Binding Protein3 | | AIG62 3 | | Rotamase3 | | FKBP-52 3 | | P541 2 | | FKBP-512 3 | | |
Export aliases for FKBP5 gene to outside databasesPrevious GC identifers: GC06M035543 GC06M035588 GC06M035649 GC06M035262 |
Summaries
for FKBP5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FKBP5:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulationand basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolylisomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition.It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDaheat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternativesplicing results in multiple transcript variants.(provided by RefSeq, Mar 2009)
UniProtKB/Swiss-Prot: FKBP5_HUMAN, Q13451Function: Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP
Gene Wiki entry for FKBP5
|
Genomic Views
for FKBP5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FKBP5 gene promoter:
E2F-3a E2F-4 E2F-5 E2F-2 HNF-3beta E2F-1 E2F SEF-1 (1) c-Myb
Other transcription factors
Search SABiosciences Chromatin IP Primers for FKBP5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FKBP5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.31 Ensembl cytogenetic band: 6p21.31 HGNC cytogenetic band: 6p21.31FKBP5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M035541: view genomic region
(about GC identifiers)
Start:
|
35,541,362 bp from pter |
End:
|
35,696,360 bp from pter |
Size:
|
154,999 bases |
Orientation:
|
minus strand |
|
Proteins
for FKBP5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FKBP5_HUMAN, Q13451 (See
protein sequence)Recommended Name: Peptidyl-prolyl cis-trans isomerase FKBP5 Size: 457 amino acids; 51212 Da
Subunit: Part of a heteromultimeric cytoplasmic complex with HSP90, HSP70 and steroid receptors. Dissociates from thecomplex when NR3C1 binds glucocorticoid
Subcellular location: Cytoplasm. Nucleus
Sequence caution: Sequence=BAD93130.1; Type=Frameshift; Positions=29;
6/22 PDB 3D structures from  and Proteopedia  for FKBP5 (see all 22):1KT0 (3D)
3O5D (3D)
3O5E (3D)
3O5F (3D)
3O5G (3D)
3O5I (3D)
Secondary accessions: F5H7R1 Q59EB8 Q5TGM6Alternative splicing: 2 isoforms: Q13451-1 Q13451-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FKBP5: NX_Q13451
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13451
4/14 DME Specific Peptides for FKBP5 (Q13451) (see all 14)
FKBP5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001139247.1 NP_001139248.1 NP_001139249.1 NP_004108.1
ENSEMBL proteins: ENSP00000338160 ENSP00000444810 ENSP00000349811 ENSP00000441205 ENSP00000445412 ENSP00000442340
Human Recombinant Protein Products for FKBP5:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
FKBP5 for ontologies About GeneDecksing
FKBP5 Antibody Products:
Assay Products for FKBP5: |
Protein
Domains /
Families
for FKBP5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FKBP5 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q13451ProtoNet protein and cluster: Q13451 UniProtKB/Swiss-Prot: FKBP5_HUMAN, Q13451Similarity: Contains 2 PPIase FKBP-type domainsSimilarity: Contains 3 TPR repeats |
Function
for FKBP5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: FKBP5_HUMAN, Q13451Function: Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBPCatalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)Enzyme regulation: Inhibited by FK506 but not cyclosporinInduction: By androgen Enzyme Number (IUBMB): EC 5.2.1.81 2
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
FKBP5 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for FKBP5:
6 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Fkbp5):
FKBP5 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP5 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP5 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): FKBP5 (NM_004117) | |  | Sino Biological Human cDNA Clone for FKBP5 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FKBP5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FKBP5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBP5 |
|
Pathways & Interactions
for FKBP5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | PI3K / Akt Signaling | | | 2 | Glucocorticoid receptor regulatory network | | | 3 | TNF-alpha/NF-kB Signaling Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for FKBP5
2  BioSystems Pathways for FKBP5
FKBP5 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FKBP5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/35 Interacting proteins for FKBP5 (Q134512, 3 ENSP000003381604) via UniProtKB, MINT, STRING, and/or I2D (see all 35)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
FKBP5 for ontologies About GeneDecksing
|
Drugs & Compounds
for FKBP5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
FKBP5 for compounds About GeneDecksing
 Browse Tocris compounds for FKBP5
1 HMDB Compound for FKBP5 About this table
10/11 Novoseek chemical compound relationships for FKBP5 gene (see all 11) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tacrolimus |
74.5 |
33 |
18326728 (3), 20023700 (3), 7693698 (3), 15089760 (2) (see all 19) |
| steroid |
60.9 |
12 |
11751894 (2), 1383226 (1), 15821585 (1), 20371398 (1) (see all 10) |
| rapamycin |
58.6 |
22 |
9658403 (3), 15878982 (2), 11089542 (1), 18320068 (1) |
| molybdate |
48.5 |
2 |
2303491 (1), 9183567 (1) |
| progestin |
48.2 |
9 |
12746298 (7) |
| dexamethasone |
47.8 |
18 |
18326728 (4), 11089542 (2), 12519866 (2), 16723223 (1) (see all 7) |
| mifepristone |
46.2 |
2 |
20371398 (1), 12746298 (1) |
| cyclosporin a |
42.8 |
8 |
20023700 (3), 11089542 (1), 12351405 (1), 12611898 (1) |
| progesterone |
41.7 |
8 |
7688746 (3), 8114727 (1), 7693698 (1), 9195978 (1) (see all 6) |
| testosterone |
36.5 |
18 |
20023700 (4), 15821585 (3), 19433513 (3), 12917209 (1) (see all 7) |
5 PharmGKB related drug/compound annotations for FKBP5 gene About this tableSearch CenterWatch for drugs/clinical trials and news about FKBP5
|
Transcripts
for FKBP5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FKBP5 gene (4 alternative transcripts): NM_001145775.1 NM_001145776.1 NM_001145777.1 NM_004117.3 Unigene Cluster for FKBP5: FK506 binding protein 5 Hs.407190 [show with all ESTs]Unigene Representative Sequence: NM_0011457776 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000337746 ENST00000536438(uc003oky.2) ENST00000357266(uc003okx.2 uc011dtf.1)
ENST00000539068(uc011dte.1) ENST00000540787 ENST00000542713(uc003okz.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP5 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP5 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): FKBP5 (NM_004117) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FKBP5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FKBP5 |
Additional cDNA sequence: AB209893.1 AF194172.1 AK093304.1 AK222807.1 AK302704.1 AK303356.1 AK312422.1 AL122066.1 BC034770.1 BC042605.1 BC111050.1 BX647390.1 HM245387.1 HM245388.1 HM245391.1 NR_027117.1 U42031.1 U71321.1 X97300.1 18 DOTS entries: DT.100810577 DT.217993 DT.100810576 DT.100036440 DT.100000254 DT.100810580 DT.91638670 DT.100801419 DT.121339202 DT.95200204 DT.121339196 DT.121339167 DT.121339223 DT.121339249 DT.75120548 DT.95136421 DT.100755214 DT.121339252 24/336 AceView cDNA sequences (see all 336): AA345703 BP377824 BQ014697 BM705679 AA789188 AL046952 X97300 AI679222 AJ715015 CD558819 AL045832 BP376819 AA366751 CB852121 AI366055 AF194172 CR620368 BX364564 BC042605 AA360668 AI220884 AW082272 BP338993 CB217026
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for FKBP5 (see all 8) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ |
|---|
|
| SP1: | | | | | | | - | | - | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | - | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 20a | · | 20b |
|---|
|
| SP1: | | | | | |
| SP2: | | | | | |
| SP3: | | | | | |
| SP4: | | | | | |
| SP5: | | | | |
ECgene alternative splicing isoforms for FKBP5
|
Expression
for FKBP5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FKBP5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTCCAGTGA
About this image
See FKBP5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FKBP5
SOURCE GeneReport for Unigene cluster: Hs.407190
UniProtKB/Swiss-Prot: FKBP5_HUMAN, Q13451Tissue specificity: Widely expressed, enriched in testis compared to other tissues
SABiosciences Custom PCR Arrays for FKBP5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FKBP5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FKBP5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FKBP5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FKBP5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBP5 |
Orthologs
for FKBP5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for FKBP5 gene from 7/26 species (see all 26) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FKBP51 |
FK506 binding protein 5 |
76.39(n)
84.19(a) |
|
421186 NM_001005431.1 NP_001005431.1 |
lizard
(Anolis carolinensis) |
Reptilia |
FKBP56 |
-- |
81(a) |
1 ↔ 1 |
GL343382.1(892005-916221) |
zebrafish
(Danio rerio) |
Actinopterygii |
fkbp51 |
FK506 binding protein 5 |
63.82(n)
62.56(a) |
|
368924 NM_213149.1 NP_998314.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
FKBP593 |
peripheral nervous system development FK506
binding |
41(a) |
|
30E1 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
fkb-63 |
FKBP-type peptidyl-prolyl cis-trans
isomerases |
41(a) |
|
V(20838115-20839280) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ROF11 |
rotamase FKBP 1 |
49.61(n)
37.27(a) |
|
822117 NM_113429.4 NP_189160.3 |
rice
(Oryza sativa) |
Liliopsida |
Os08g05256001 |
hypothetical protein |
50.62(n)
37.47(a) |
|
4346090 NM_001068827.1 NP_001062292.1 |
ENSEMBL Gene Tree for FKBP5 (if available)
TreeFam Gene Tree for FKBP5 (if available) |
Paralogs
for FKBP5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FKBP5 gene
- FKBP1A2 FKBP42 FKBP1C2 FKBP82 FKBP62 FKBP1B2 FKBP32
6 SIMAP similar genes for FKBP5 using alignment to 5 protein entries: FKBP5_HUMAN (see all proteins):FKBP4 FKBP12-Exip2 FKBP1B FKBP1A FKBP1C FKBP2
FKBP5 for paralogs About GeneDecksing
|
Genomic Variants
for FKBP5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FKBP5 (35541362 - 35696360 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 29 variations for FKBP5
15/25 CNVs (see all 25): 36516 51903 51906 31284 43539 81370 81368 44255 37752 31283 99504 93672 64485 81369 53613
3 Indels: 93673 69487 60588
1 Inversion: 37274
Human Gene Mutation Database (HGMD): FKBP5
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FKBP5 |
|
Disorders
/ Diseases
for FKBP5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FKBP5 for disorders About GeneDecksing
OMIM gene information: 602623
OMIM disorders: 608516
20/32  diseases for FKBP5 (see all 32): About MalaCardsopen-angle glaucoma post-traumatic stress disorder primary open angle glaucoma major depressive disorder
glucocorticoid resistance anxiety disorder glaucoma inflammatory bowel disease
myelofibrosis acute lymphoblastic leukemia lymphoblastic leukemia acute myeloid leukemia
mood disorder addison's disease myeloid leukemia ulcerative colitis
fibromyalgia bipolar disorder multiple myeloma rheumatoid arthritis
6 Novoseek disease relationships for FKBP5 gene About this table
Genetic Association Database (GAD): FKBP5
Human Genome Epidemiology (HuGE) Navigator: FKBP5 (29 documents)
Export disorders for FKBP5 gene to outside databases
|
Publications
for FKBP5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FKBP5 gene, integrated from 9 sources (see all 182):
(articles sorted by number of sources associating them with FKBP5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor. (PubMed id 9001212)1, 2, 3 Nair S.C.... Smith D.F. (1997)
- Tissue distribution and abundance of human FKBP51, an FK506-binding protein that can mediate calcineurin inhibition. (PubMed id 9125197)1, 2, 9 Baughman G.... Bourgeois S. (1997)
- FKBP54, a novel FK506-binding protein in avian progesterone receptor complexes and HeLa extracts. (PubMed id 7693698)1, 2, 9 Smith D.F.... Deibel M.R. Jr. (1993)
- Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. (PubMed id 15565110)1, 4 Binder E.B....Muller-Myhsok B. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes. (PubMed id 12538866)1, 2 Sinars C.R.... Clardy J. (2003)
- Constitutive expression of the FK506 binding protein 51 (FKBP51) in bone marrow cells and megakaryocytes derived from idiopathic myelofibrosis and non-neoplastic haematopoiesis. (PubMed id 15089760)1, 9 Bock O....Kreipe H. (2004)
- FK506 binding protein mediates glioma cell growth and sensitivity to rapamycin treatment by regulating NF-kappaB signaling pathway. (PubMed id 18320068)1, 9 Jiang W....Mikkelsen T. (2008)
- The FK506-binding immunophilin FKBP51 is transcriptionally regulated by progestin and attenuates progestin responsiveness. (PubMed id 12746298)1, 9 Hubler T.R....Scammell J.G. (2003)
- FKBP51 and Cyp40 are positive regulators of androgen- dependent prostate cancer cell growth and the targets of FK506 and cyclosporin A. (PubMed id 20023700)1, 9 Periyasamy S....Sanchez E.R. (2010)
|
External Searches for FKBP5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FKBP5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FKBP5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FKBP5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for FKBP5 gene:
Search GeneIP for patents involving FKBP5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FKBP5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for FKBP5 | | OriGene shRNA RFP for FKBP5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FKBP5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FKBP5 | | | OriGene Protein Over-expression Lysate for FKBP5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FKBP5 | | OriGene 3'-UTR Clone for FKBP5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FKBP5 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FKBP5 | | OriGene Custom Protein Services for FKBP5 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FKBP5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FKBP5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FKBP5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FKBP5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FKBP5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FKBP5 |
| |
 |  |  |  | |
| | Antibodies & Assays for FKBP5 |
| | | | Search Tocris compounds for FKBP5 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | FKBP5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBP5 |
|  |  |  |  | | | | ThermoFisher Antibody for FKBP5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FKBP5 |
| |  | |
|
|
|
