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Aliases for FKBP5 Gene

Aliases for FKBP5 Gene

  • FK506 Binding Protein 5 2 3
  • FKBP51 3 4 6
  • 54 KDa Progesterone Receptor-Associated Immunophilin 3 4
  • 51 KDa FK506-Binding Protein 3 4
  • Androgen-Regulated Protein 6 3 4
  • HSP90-Binding Immunophilin 3 4
  • FK506-Binding Protein 5 2 4
  • PPIase FKBP5 3 4
  • 51 KDa FKBP 3 4
  • FF1 Antigen 3 4
  • EC 5.2.1.8 4 64
  • Rotamase 3 4
  • FKBP-51 3 4
  • FKBP54 3 4
  • AIG6 3 4
  • P54 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase FKBP5 3
  • Peptidylprolyl Cis-Trans Isomerase 3
  • T-Cell FK506-Binding Protein 3
  • PPIASE 3
  • Ptg-10 3
  • FKBP-5 4

External Ids for FKBP5 Gene

Summaries for FKBP5 Gene

Entrez Gene Summary for FKBP5 Gene

  • The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

GeneCards Summary for FKBP5 Gene

FKBP5 (FK506 Binding Protein 5) is a Protein Coding gene. Diseases associated with FKBP5 include major depressive disorder and accelerated response to antidepressant drug treatment and post-traumatic stress disorder. Among its related pathways are Glucocorticoid receptor regulatory network and Prostate Cancer. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and FK506 binding. An important paralog of this gene is FKBP1A.

UniProtKB/Swiss-Prot for FKBP5 Gene

  • Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded

Gene Wiki entry for FKBP5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBP5 Gene

Genomics for FKBP5 Gene

Genomic Location for FKBP5 Gene

Start:
35,573,585 bp from pter
End:
35,728,583 bp from pter
Size:
154,999 bases
Orientation:
Minus strand

Genomic View for FKBP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FKBP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP5 Gene

Regulatory Elements for FKBP5 Gene

Proteins for FKBP5 Gene

  • Protein details for FKBP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13451-FKBP5_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP5
    Protein Accession:
    Q13451
    Secondary Accessions:
    • F5H7R1
    • Q59EB8
    • Q5TGM6

    Protein attributes for FKBP5 Gene

    Size:
    457 amino acids
    Molecular mass:
    51212 Da
    Quaternary structure:
    • Part of a heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B and steroid receptors. Upon ligand binding dissociates from the complex and FKBP4 takes its place. Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP
    SequenceCaution:
    • Sequence=BAD93130.1; Type=Frameshift; Positions=29; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FKBP5 Gene

    Alternative splice isoforms for FKBP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FKBP5 Gene

Proteomics data for FKBP5 Gene at MOPED

Post-translational modifications for FKBP5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys352 and Lys376

Other Protein References for FKBP5 Gene

Domains for FKBP5 Gene

Gene Families for FKBP5 Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

UniProtKB/Swiss-Prot:

FKBP5_HUMAN
Domain:
  • Contains 2 PPIase FKBP-type domains.:
    • Q13451
Similarity:
  • Contains 3 TPR repeats.:
    • Q13451
genes like me logo Genes that share domains with FKBP5: view

Function for FKBP5 Gene

Molecular function for FKBP5 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Peptidylproline (omega=180) = peptidylproline (omega=0)
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by FK506 but not cyclosporin
UniProtKB/Swiss-Prot Function: Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded
UniProtKB/Swiss-Prot Induction: By androgen

Enzyme Numbers (IUBMB) for FKBP5 Gene

Gene Ontology (GO) - Molecular Function for FKBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IDA 11350175
GO:0005515 protein binding IPI 14676191
GO:0005528 FK506 binding IBA --
GO:0031072 heat shock protein binding IPI 9660753
genes like me logo Genes that share ontologies with FKBP5: view
genes like me logo Genes that share phenotypes with FKBP5: view

miRNA for FKBP5 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for FKBP5 Gene

Localization for FKBP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP5 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FKBP5 Gene COMPARTMENTS Subcellular localization image for FKBP5 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FKBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005789 endoplasmic reticulum membrane IBA --
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with FKBP5: view

Pathways for FKBP5 Gene

genes like me logo Genes that share pathways with FKBP5: view

Pathways by source for FKBP5 Gene

1 Cell Signaling Technology pathway for FKBP5 Gene
1 KEGG pathway for FKBP5 Gene

Gene Ontology (GO) - Biological Process for FKBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0006457 protein folding TAS 9001212
GO:0061077 chaperone-mediated protein folding IDA 11350175
genes like me logo Genes that share ontologies with FKBP5: view

Compounds for FKBP5 Gene

(1) HMDB Compounds for FKBP5 Gene

Compound Synonyms Cas Number PubMed IDs
Progesterone
  • 17a-Progesterone
57-83-0

(11) Novoseek inferred chemical compound relationships for FKBP5 Gene

Compound -log(P) Hits PubMed IDs
tacrolimus 74.5 28
steroid 60.9 11
rapamycin 58.6 7
molybdate 48.5 2
progestin 48.2 7

(12) PharmGKB related drug/compound annotations for FKBP5 Gene

genes like me logo Genes that share compounds with FKBP5: view

Transcripts for FKBP5 Gene

Unigene Clusters for FKBP5 Gene

FK506 binding protein 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^
SP1: - - - - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - -
SP4: - -
SP5: -
SP6: - - - -
SP7: -
SP8:

ExUns: 20a · 20b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for FKBP5 Gene

GeneLoc Exon Structure for
FKBP5
ECgene alternative splicing isoforms for
FKBP5

Expression for FKBP5 Gene

mRNA expression in normal human tissues for FKBP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FKBP5 Gene

This gene is overexpressed in Muscle - Skeletal (8.8) and Whole Blood (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for FKBP5 Gene

SOURCE GeneReport for Unigene cluster for FKBP5 Gene Hs.407190

mRNA Expression by UniProt/SwissProt for FKBP5 Gene

Q13451-FKBP5_HUMAN
Tissue specificity: Widely expressed, enriched in testis compared to other tissues
genes like me logo Genes that share expressions with FKBP5: view

Orthologs for FKBP5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FKBP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FKBP5 36
  • 99.93 (n)
  • 99.78 (a)
FKBP5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FKBP5 36
  • 93.07 (n)
  • 95.19 (a)
FKBP5 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FKBP5 36
  • 92.4 (n)
  • 95.39 (a)
FKBP5 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fkbp5 36
  • 84.58 (n)
  • 87.28 (a)
Fkbp5 16
Fkbp5 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FKBP5 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-7424 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fkbp5 36
  • 86.26 (n)
  • 91.45 (a)
chicken
(Gallus gallus)
Aves FKBP5 36
  • 76.39 (n)
  • 84.19 (a)
FKBP51 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FKBP5 37
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fkbp5 36
  • 63.82 (n)
  • 62.56 (a)
fkbp5 37
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta FKBP59 37
  • 41 (a)
OneToMany
FKBP59 38
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea fkb-6 37
  • 39 (a)
OneToMany
fkb-6 38
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPR1 37
  • 43 (a)
OneToMany
FPR3 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 51 (a)
ManyToMany
Species with no ortholog for FKBP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FKBP5 Gene

ENSEMBL:
Gene Tree for FKBP5 (if available)
TreeFam:
Gene Tree for FKBP5 (if available)

Paralogs for FKBP5 Gene

Paralogs for FKBP5 Gene

Selected SIMAP similar genes for FKBP5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FKBP5: view

Variants for FKBP5 Gene

Sequence variations from dbSNP and Humsavar for FKBP5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs737054 -- 35,607,710(-) AGCAG(C/T)GGCTG intron-variant
rs747411 -- 35,618,596(+) gtctc(A/G)aattc intron-variant
rs943297 -- 35,700,083(-) agtta(A/G)gtcCT intron-variant
rs1080946 -- 35,669,535(-) GTTCA(A/G)GAAAT intron-variant
rs1320991 -- 35,594,655(-) GTATA(A/G)AAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FKBP5 Gene

Variant ID Type Subtype PubMed ID
dgv1940e1 CNV Complex 17122850
nsv7889 CNV Gain 18304495
dgv751n27 CNV Gain 19166990
nsv470813 CNV Gain 18288195
nsv818412 CNV Gain 17921354
nsv462913 CNV Gain 19166990
nsv517211 CNV Gain 19592680
esv2421382 CNV Duplication 20811451
nsv441992 CNV CNV 18776908
nsv885801 CNV Gain 21882294
esv7205 CNV Gain 19470904
nsv7379 OTHER Inversion 18451855
nsv5258 CNV Loss 18451855
nsv821646 CNV Loss 15273396
nsv508403 CNV Loss 20534489
dgv6834n71 CNV Gain 21882294
nsv511349 CNV Loss 21212237
esv2169093 CNV Deletion 18987734
esv987803 CNV Deletion 20482838
esv2603863 CNV Deletion 19546169
nsv511880 CNV Loss 21212237
esv5263 CNV Deletion 18987735
esv2731911 CNV Deletion 23290073
esv2669578 CNV Deletion 23128226
nsv499295 CNV Loss 21111241
esv6703 CNV Loss 19470904
esv1362467 CNV Deletion 17803354
esv25611 CNV Gain 19812545
nsv820606 CNV Deletion 20802225
nsv514355 CNV Loss 21397061
dgv1941e1 CNV Complex 17122850
nsv428143 CNV Gain 18775914
esv2731912 CNV Deletion 23290073
esv1964718 CNV Deletion 18987734
esv2731913 CNV Deletion 23290073
esv29881 CNV Loss 19812545
nsv512875 CNV Insertion 21212237
esv1163117 CNV Insertion 17803354
nsv885805 CNV Loss 21882294
nsv7890 CNV Gain 18304495

Relevant External Links for FKBP5 Gene

HapMap Linkage Disequilibrium report
FKBP5
Human Gene Mutation Database (HGMD)
FKBP5

Disorders for FKBP5 Gene

(1) OMIM Diseases for FKBP5 Gene (602623)

(6) Novoseek inferred disease relationships for FKBP5 Gene

Disease -log(P) Hits PubMed IDs
idiopathic myelofibrosis 66.9 4
shock 37.4 6
prostate cancer 30.8 5
mammary tumor 19.4 1
tumors 0 3

Relevant External Links for FKBP5

Genetic Association Database (GAD)
FKBP5
Human Genome Epidemiology (HuGE) Navigator
FKBP5
genes like me logo Genes that share disorders with FKBP5: view

No data available for UniProtKB/Swiss-Prot for FKBP5 Gene

Publications for FKBP5 Gene

  1. Tissue distribution and abundance of human FKBP51, an FK506-binding protein that can mediate calcineurin inhibition. (PMID: 9125197) Baughman G. … Bourgeois S. (Biochem. Biophys. Res. Commun. 1997) 3 4 23
  2. FKBP54, a novel FK506-binding protein in avian progesterone receptor complexes and HeLa extracts. (PMID: 7693698) Smith D.F. … Deibel M.R. Jr. (J. Biol. Chem. 1993) 3 4 23
  3. The FKBP5-gene in depression and treatment response--an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Cohort. (PMID: 18191112) Lekman M. … Paddock S. (Biol. Psychiatry 2008) 3 23 49
  4. Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. (PMID: 18349090) Binder E.B. … Ressler K.J. (JAMA 2008) 3 23 49
  5. Genetic variants in FKBP5 affecting response to antidepressant drug treatment. (PMID: 18597649) Kirchheiner J. … BrockmAPller J. (Pharmacogenomics 2008) 3 23 49

Products for FKBP5 Gene

Sources for FKBP5 Gene

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