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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FKBP4 Gene

protein-coding   GIFtS: 67
GCID: GC12P002904

FK506 Binding Protein 4, 59kDa

(Previous name: FK506-binding protein 4 (59kD))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
FK506 Binding Protein 4, 59kDa1 2     rotamase2
FK506-Binding Protein 4 (59kD)1 2     T-Cell FK506-Binding Protein, 59kD2
51 KDa FK506-Binding Protein2 3     52 KDa FK506-Binding Protein3
FKBP512 3     52 KDa FKBP3
FKBP522 3     59 KDa Immunophilin3
FKBP592 3     FKBP-43
HBI2 3     FKBP-523
EC 5.2.1.83 8     Rotamase3
Hsp562     FK506-Binding Protein 43
PPIase2     HSP-Binding Immunophilin3
HSP Binding Immunophilin2     Immunophilin FKBP523
p522     p593
Peptidyl-Prolyl Cis-Trans Isomerase FKBP42     PPIase FKBP43
Peptidylprolyl Cis-Trans Isomerase2     

External Ids:    HGNC: 37201   Entrez Gene: 22882   Ensembl: ENSG000000044787   OMIM: 6006115   UniProtKB: Q027903   

Export aliases for FKBP4 gene to outside databases

Previous GC identifers: GC12P002776 GC12P002797 GC12P002774 GC12P002764


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FKBP4 Gene:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in
immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is
a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and
functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have
immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays
an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to
associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and
hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid
hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in
a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is
thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome
contains several non-transcribed pseudogenes similar to this gene. (provided by RefSeq, Sep 2008)

GeneCards Summary for FKBP4 Gene: 
FKBP4 (FK506 binding protein 4, 59kDa) is a protein-coding gene. Diseases associated with FKBP4 include facial paralysis, and in situ carcinoma, and among its related super-pathways are Development Glucocorticoid receptor signaling and PGC1Alpha Pathway. GO annotations related to this gene include GTP binding and protein binding, bridging. An important paralog of this gene is FKBP5.

UniProtKB/Swiss-Prot: FKBP4_HUMAN, Q02790
Function: Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unligated
steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the
intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear
compartments (By similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1
channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote
microtubule assembly. May have a protective role against oxidative stress in mitochondria

Gene Wiki entry for FKBP4 (FKBP52) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009759.16  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FKBP4 gene promoter:
         Bach1   SRF   Sp1   SRF (504 AA)   FAC1   CP2   FOXJ2 (long isoform)   HSF2   FOXJ2   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFKBP4 promoter sequence
   Search SABiosciences Chromatin IP Primers for FKBP4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FKBP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.33   Ensembl cytogenetic band:  12p13.33   HGNC cytogenetic band: 12p13.33

FKBP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FKBP4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P002904:  view genomic region     (about GC identifiers)

Start:
2,904,108 bp from pter      End:
2,914,589 bp from pter
Size:
10,482 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FKBP4_HUMAN, Q02790 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase FKBP4  
Size: 459 amino acids; 51805 Da
Subunit: Homodimer. Associates with HSP90 and HSP70 in unactivated steroid hormone receptor complexes. Also
interacts with peroxisomal phytanoyl-CoA alpha-hydroxylase (PHYH). Interacts with HSF1 in the HSP90 complex.
Associates with tubulin (By similarity). Interacts with MAPT/TAU (By similarity). Interacts with NR3C1 and dynein
(By similarity). Interacts (via TPR domain) with S100A1, S100A2 and S100A6; the interaction is Ca(2+) dependent.
Interaction with S100A1 and S100A2 (but not with S100A6) leads to inhibition of FKBP4-HSP90 interaction
Subcellular location: Cytoplasm, cytosol (By similarity). Mitochondrion. Nucleus. Cytoplasm, cytoskeleton (By
similarity). Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid
receptor
5 PDB 3D structures from and Proteopedia for FKBP4:
1N1A (3D)        1P5Q (3D)        1Q1C (3D)        1QZ2 (3D)        4DRJ (3D)    
Secondary accessions: D3DUQ1 Q9UCP1 Q9UCV7

Explore the universe of human proteins at neXtProt for FKBP4: NX_Q02790

Explore proteomics data for FKBP4 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation by CK2 results in loss of HSP90 binding activity (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q02790

  • 4/12 DME Specific Peptides for FKBP4 (Q02790) (see all 12)
     KIVSWLE  IPPNATL  GSPPKIP  TRGEGYA 

    FKBP4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FKBP4 Protein Expression
    REFSEQ proteins: NP_002005.1  
    ENSEMBL proteins: 
     ENSP00000001008   ENSP00000439703   ENSP00000446368   ENSP00000438491   ENSP00000442193  

    Human Recombinant Protein Products for FKBP4: 
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    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for FKBP4
    Cloud-Clone Corp. Proteins for FKBP4 

    Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular NAS--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--

    FKBP4 for ontologies           About GeneDecksing



    FKBP4 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TTC: Tetratricopeptide (TTC) repeat domain containing

    5/6 InterPro protein domains (see all 6):
     IPR011990 TPR-like_helical
     IPR023566 PPIase_FKBP
     IPR001440 TPR-1
     IPR001179 PPIase_FKBP_dom
     IPR013026 TPR-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q02790

    ProtoNet protein and cluster: Q02790

    UniProtKB/Swiss-Prot: FKBP4_HUMAN, Q02790
    Domain: The PPIase activity is mainly due to the fisrt PPIase FKBP-type domain (1-138 AA) (By similarity)
    Domain: The C-terminal region (AA 375-458) is required to prevent tubulin polymerization (By similarity)
    Domain: The chaperone activity resides in the C-terminal region, mainly between amino acids 264 and 400 (By
    similarity)
    Domain: The TPR repeats mediate mitochondrial localization
    Similarity: Contains 2 PPIase FKBP-type domains
    Similarity: Contains 3 TPR repeats


    FKBP4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FKBP4_HUMAN, Q02790
    Function: Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unligated
    steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the
    intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear
    compartments (By similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1
    channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote
    microtubule assembly. May have a protective role against oxidative stress in mitochondria
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)
    Enzyme regulation: Inhibited by FK506

         Enzyme Number (IUBMB): EC 5.2.1.81 2

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity IDA11350175
    GO:0005515protein binding IPI12604780
    GO:0005524ATP binding IEA--
    GO:0005525GTP binding IEA--
    GO:0005528FK506 binding TAS1376003
         
    FKBP4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FKBP4:
     Increased Salmonella enterica  

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fkbp4):
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     integument  mortality/aging  renal/urinary system  reproductive system 

    FKBP4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FKBP4: Fkbp4tm1Dvds Fkbp4tm1Shou

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FKBP4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FKBP4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FKBP4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FKBP4 

    miRNA
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    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate FKBP4 (see all 34):
    hsa-miR-4291 hsa-miR-3678-3p hsa-miR-140-5p hsa-miR-642a hsa-miR-4328 hsa-miR-29a hsa-miR-548m hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidFKBP4 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBP4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FKBP4 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development Glucocorticoid receptor signaling
    Development Glucocorticoid receptor signaling1.00
    2PEDF Induced Signaling
    Glucocorticoid Receptor Signaling0.43
    3Development Endothelin-1/EDNRA signaling
    Estrogen signaling pathway0.34
    4Golgi to ER Retrograde Transport
    Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)0.31
    5Glucocorticoid receptor regulatory network
    Glucocorticoid receptor regulatory network

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for FKBP4
        Development Glucocorticoid receptor signaling

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for FKBP4
        Glucocorticoid Receptor Signaling

    2 GeneGo (Thomson Reuters) Pathways for FKBP4
        Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)
    Development Glucocorticoid receptor signaling

    3 BioSystems Pathways for FKBP4
        Androgen receptor signaling pathway
    Glucocorticoid receptor regulatory network
    Coregulation of Androgen receptor activity

    1 PharmGKB Pathway for FKBP4
        Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics

    1         Kegg Pathway  (Kegg details for FKBP4):
        Estrogen signaling pathway


    FKBP4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FKBP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/52 Interacting proteins for FKBP4 (Q027902, 3 ENSP000000010084) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    S100A2P290342, 3, ENSP000003576974MINT-7710374 MINT-7710476 MINT-7710432 I2D: score=1 STRING: ENSP00000357697
    HSP90AA1P079002, 3, ENSP000003351534MINT-7710316 MINT-7710476 MINT-7710488 MINT-7710224 I2D: score=3 STRING: ENSP00000335153
    S100A6P067032, 3, ENSP000003577084MINT-7710442 MINT-7710387 MINT-7710488 I2D: score=1 STRING: ENSP00000357708
    YWHAZP631042, 3, ENSP000003095034MINT-3319393 I2D: score=1 STRING: ENSP00000309503
    NR3C1P041503, ENSP000002315094I2D: score=4 STRING: ENSP00000231509
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000413protein peptidyl-prolyl isomerization IDA11350175
    GO:0006457protein folding TAS1279700
    GO:0006463steroid hormone receptor complex assembly IEA--
    GO:0006825copper ion transport IEA--
    GO:0007566embryo implantation IEA--

    FKBP4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FKBP4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FKBP4

    1 HMDB Compound for FKBP4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Dimethyl sulfoxide(methylsulfinyl)methane;Dimethyl sulfoxide (see all 5)67-68-5--

    10/19 Novoseek inferred chemical compound relationships for FKBP4 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tacrolimus 81.8 52 7504525 (4), 8955134 (3), 15697228 (2), 7689858 (2) (see all 30)
    steroid 70.2 37 10718488 (2), 7915146 (2), 2266108 (2), 1279700 (2) (see all 26)
    radicicol 65 1 19581287 (1)
    chlorothalonil 64.5 1 8157642 (1)
    rapamycin 63.9 13 7530727 (3), 8955134 (2), 7689858 (1), 15862952 (1) (see all 8)
    molybdate 60.5 3 9183567 (1), 8157642 (1)
    progesterone 42.5 5 1922029 (2), 7688746 (1), 18771283 (1)
    novobiocin 40.2 1 15209518 (1)
    cyclosporin a 34 3 15862952 (1), 8602846 (1)
    tyrosine 24.9 26 12552015 (4), 11533160 (3), 14711833 (2), 18087261 (2) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about FKBP4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FKBP4 gene: 
    NM_002014.3  

    Unigene Cluster for FKBP4:

    FK506 binding protein 4, 59kDa
    Hs.524183  [show with all ESTs]
    Unigene Representative Sequence: NM_002014
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000001008(uc001qkz.3) ENST00000543769 ENST00000540260 ENST00000538622
    ENST00000543037 ENST00000539181 ENST00000544366
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    Additional mRNA sequence: 

    AK024694.1 AK313918.1 BC001786.1 BC002887.2 BC007924.2 M88279.1 

    24/31 DOTS entries (see all 31):

    DT.95162460  DT.318893  DT.100670975  DT.100045862  DT.100670969  DT.91828546  DT.100805434  DT.100670977 
    DT.121115141  DT.40105966  DT.92347167  DT.121115030  DT.91814730  DT.95162448  DT.95162483  DT.100670973 
    DT.121115084  DT.121115190  DT.121115206  DT.121115225  DT.121160235  DT.121168127  DT.121197953  DT.92004655 

    24/547 AceView cDNA sequences (see all 547):

    BU856857 BG030360 BC002887 BQ691450 BU176390 BM684329 CA419246 BQ059244 
    BQ059307 BC001786 BQ962051 BM916927 BQ687971 BE791066 BE254086 AA923017 
    BM693958 CB528465 AW873631 CR616201 BG751875 BQ049735 BC006552 BM790361 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for FKBP4    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                                                  
    SP2:                                                                  


    ECgene alternative splicing isoforms for FKBP4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FKBP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTGAGCAAT
    FKBP4 Expression
    About this image


    See FKBP4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FKBP4

    SOURCE GeneReport for Unigene cluster: Hs.524183

    UniProtKB/Swiss-Prot: FKBP4_HUMAN, Q02790
    Tissue specificity: Widely expressed

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FKBP4 gene from 9/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fkbp41 , 5 FK506 binding protein 41, 5 87.48(n)1
    89.96(a)1
      6 (63.00 cM)5
    142281  NM_010219.31  NP_034349.11 
     1284297355 
    chicken
    (Gallus gallus)
    Aves FKBP41 FK506 binding protein 4, 59kDa 72.71(n)
    77.75(a)
      418261  NM_001006250.1  NP_001006250.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia BU905331.12   -- 73.18(n)    BU905331.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.34732 Danio rerio mRNA similar to FK506 binding protein 4, more 74.02(n)    BC045387.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta FKBP591 , 3 peripheral nervous system development
    FK506 binding3
    FK506-binding protein FKBP591
    44(a)3
    55.8(n)1
    45.77(a)1
      30E13
    477621  NM_080156.31  NP_524895.21 
    worm
    (Caenorhabditis elegans)
    Secernentea fkb-61 , 3 FKBP-type peptidyl-prolyl cis-trans
    isomerases3
    Protein FKB-61
    42(a)3
    50.43(n)1
    43.5(a)1
      V(20838115-20839280)3
    1803711  NM_075625.41  NP_508026.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FPR16
    Peptidyl-prolyl cis-trans isomerase (PPIase), bind...
    45(a)
    1 → many
    XIV(371882-372226)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ROF21 peptidylprolyl isomerase 49.32(n)
    39.34(a)
      834913  NM_124233.2  NP_199668.1 
    rice
    (Oryza sativa)
    Liliopsida Os.111242 Oryza sativa (indica cultivar-group) mRNA for peptidylprolyl more 72.93(n)    AJ557547.1 


    ENSEMBL Gene Tree for FKBP4 (if available)
    TreeFam Gene Tree for FKBP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FKBP4 gene
    FKBP52  FKBP1A2  FKBP1C2  FKBP82  FKBP62  FKBP1B2  FKBP32  
    10 SIMAP similar genes for FKBP4 using alignment to 5 protein entries:     FKBP4_HUMAN (see all proteins):
    FKBP5    FKBP12-Exip2    FKBP1A    FKBP1C    FKBP1B    FKBP2
    FKBP10    FKBP7    FKBP14    FKBP8

    FKBP4 for paralogs           About GeneDecksing


    5/8 Pseudogenes.org Pseudogenes for FKBP4 (see all 8)
    PGOHUM00000245670 PGOHUM00000236060 PGOHUM00000236088 PGOHUM00000236107 PGOHUM00000236147


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/309 SNPs in FKBP4 are shown (see all 309)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0506244
    ----see VAR_0506242 T P mis40--------
    rs1510782401,2
    --2902235(+) CTTACC/TCCAAA 1 -- us2k10--------
    rs1425503391,2
    --2902322(+) CGTGCC/TGAACA 1 -- us2k10--------
    rs1468963711,2
    --2902323(+) GTGCCA/GAACAG 1 -- us2k10--------
    rs1119628941,2
    C--2902335(+) TTAAAG/-GGGGG 1 -- us2k11Minor allele frequency- -:0.00CSA 2
    rs785874321,2
    F--2902588(+) CTAAAG/AAGACG 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1919086941,2
    --2902601(+) TTCATC/TATGGC 1 -- us2k10--------
    rs1115113051,2
    F--2902652(+) TTTCTG/TCTGCA 1 -- us2k12Minor allele frequency- T:0.50CSA 4
    rs1136587341,2
    F--2902761(+) AATGGC/TGTCCA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1393266621,2
    --2902813(+) AGTTAC/TTATTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FKBP4 (2904108 - 2914589 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FKBP4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv26689CNV Loss19812545
    dgv19n68CNV Loss17160897
    nsv826195CNV Gain20364138
    nsv826194CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600611    OMIM disorders: --

    20/31 diseases for FKBP4 (see all 31):    About MalaCards
    facial paralysis    in situ carcinoma    acoustic neuroma    neuroma
    refsum disease    major depressive disorder    paralysis    open-angle glaucoma
    primary open angle glaucoma    hypospadias    lupus nephritis    glaucoma
    nephritis    male infertility    lipodystrophy    infertility
    endometriosis    multiple myeloma    myeloma    influenza

    2 diseases from the University of Copenhagen DISEASES database for FKBP4:
    Facial paralysis     Acoustic neuroma

    FKBP4 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for FKBP4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 56.5 33 8157642 (3), 1922029 (2), 7689858 (2), 11525244 (2) (see all 16)
    breast cancer 6.29 10 10718488 (4), 19584157 (3), 11374893 (2)
    breast carcinoma 0 1 10718488 (1)
    neurological disorders 0 1 15713424 (1)
    tumors 0 3 10718488 (2), 19584157 (1)

    Genetic Association Database (GAD): FKBP4
    Human Genome Epidemiology (HuGE) Navigator: FKBP4 (5 documents)

    Export disorders for FKBP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FKBP4 gene, integrated from 9 sources (see all 197):
    (articles sorted by number of sources associating them with FKBP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes. (PubMed id 1279700)1, 2, 3, 9 Peattie D.A.... Benasutti M. (1992)
    2. Studies of a co-chaperone of the androgen receptor, FKBP52, as candidate for hypospadias. (PubMed id 17343741)1, 4, 9 Beleza-Meireles A....Nordenskjold A. (2007)
    3. 3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex. (PubMed id 15159550)1, 2, 9 Wu B....Rao Z. (2004)
    4. S100 proteins regulate the interaction of Hsp90 with Cyclophilin 40 and FKBP52 through their tetratricopeptide repeats. (PubMed id 20188096)1, 2, 9 Shimamoto S....Kobayashi R. (2010)
    5. Assessment of SNPs associated with the human glucocor ticoid receptor in primary open-angle glaucoma and steroid responders. (PubMed id 20376328)1, 4, 9 Fingert J.H....Clark A.F. (2010)
    6. The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52. (PubMed id 9392437)1, 2, 9 Bruner K.L.... Litwack G. (1997)
    7. Genome-wide association studies in an isolated founde r population from the Pacific Island of Kosrae. (PubMed id 19197348)1, 4 Lowe J.K....Friedman J.M. (2009)
    8. Peptidyl-prolyl isomerase FKBP52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening. (PubMed id 19945390)1, 2 Shim S....Worley P.F. (2009)
    9. The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids. (PubMed id 19254810)1, 4 Hawkins G.A....Bleecker E.R. (2009)
    10. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2288 HGNC: 3720 AceView: FKBP4andMDS028 Ensembl:ENSG00000004478 euGenes: HUgn2288
    ECgene: FKBP4 Kegg: 2288 H-InvDB: FKBP4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FKBP4 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt118.shtml

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FKBP4 gene:
    Search GeneIP for patents involving FKBP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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