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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FKBP4 Gene

protein-coding   GIFtS: 66
GCID: GC12P002904

FK506 binding protein 4, 59kDa

(Previous name: FK506-binding protein 4 (59kD) )
 Explore 32 diseases affiliated with
FKBP4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FKBP4    

Aliases
for FKBP4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
FK506 Binding Protein 4, 59kDa1 2     Rotamase3
FKBP521 2 3     T-Cell FK506-Binding Protein, 59kD2
FKBP591 2 3     52 KDa FK506-Binding Protein3
FK506-Binding Protein 4 (59kD)1 2     52 KDa FKBP3
51 KDa FK506-Binding Protein2 3     59 KDa Immunophilin3
FKBP512 3     FKBP-43
HBI2 3     FKBP-523
EC 5.2.1.83 8     Rotamase3
Hsp562     FK506-Binding Protein 43
PPIase2     HSP-Binding Immunophilin3
HSP Binding Immunophilin2     Immunophilin FKBP523
P521     P591
Peptidyl-Prolyl Cis-Trans Isomerase FKBP42     PPIase FKBP43
Peptidylprolyl Cis-Trans Isomerase2     

External Ids:    HGNC: 37201   Entrez Gene: 22882   Ensembl: ENSG000000044787   OMIM: 6006115   UniProtKB: Q027903   

Export aliases for FKBP4 gene to outside databases

Previous GC identifers: GC12P002776 GC12P002797 GC12P002774 GC12P002764


Summaries
for FKBP4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FKBP4:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation
and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl
isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity
to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when
complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory
gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA
alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in
the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates
strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated
transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the
optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes
similar to this gene. (provided by RefSeq, Sep 2008)

UniProtKB/Swiss-Prot: FKBP4_HUMAN, Q02790
Function: Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unligated steroid
receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular
trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By
similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also
as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a
protective role against oxidative stress in mitochondria

Gene Wiki entry for FKBP4 (FKBP52)


Genomic Views
for FKBP4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009759.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FKBP4 gene promoter:
         Bach1   SRF   Sp1   SRF (504 AA)   FAC1   CP2   FOXJ2 (long isoform)   HSF2   FOXJ2   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FKBP4 promoter sequence
   Search SABiosciences Chromatin IP Primers for FKBP4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FKBP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.33   Ensembl cytogenetic band:  12p13.33   HGNC cytogenetic band: 12p13.33

FKBP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FKBP4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P002904:  view genomic region     (about GC identifiers)

Start:
 2,904,108 bp from pter      End:
 2,914,589 bp from pter
Size:
 10,482 bases      Orientation:
 plus strand

Proteins
for FKBP4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FKBP4_HUMAN, Q02790 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase FKBP4  
Size: 459 amino acids; 51805 Da
Subunit: Homodimer. Associates with HSP90 and HSP70 in unactivated steroid hormone receptor complexes. Also interacts
with peroxisomal phytanoyl-CoA alpha-hydroxylase (PHYH). Interacts with HSF1 in the HSP90 complex. Associates with
tubulin (By similarity). Interacts with MAPT/TAU (By similarity). Interacts with NR3C1 and dynein (By similarity).
Interacts (via TPR domain) with S100A1, S100A2 and S100A6; the interaction is Ca(2+) dependent. Interaction with
S100A1 and S100A2 (but not with S100A6) leads to inhibition of FKBP4-HSP90 interaction
Subcellular location: Cytoplasm, cytosol (By similarity). Mitochondrion. Nucleus. Cytoplasm, cytoskeleton (By
similarity). Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor
5 PDB 3D structures from and Proteopedia for FKBP4:
1N1A (3D)        1P5Q (3D)        1Q1C (3D)        1QZ2 (3D)        4DRJ (3D)    
Secondary accessions: D3DUQ1 Q9UCP1 Q9UCV7

Explore the universe of human proteins at neXtProt for FKBP4: NX_Q02790

Post-translational modifications:

  • Phosphorylation by CK2 results in loss of HSP90 binding activity (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q02790

    • 4/12 DME Specific Peptides for FKBP4 (Q02790) (see all 12)
     KIVSWLE  IPPNATL  GSPPKIP  TRGEGYA 

    FKBP4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002005.1  
    ENSEMBL proteins: 
     ENSP00000001008   ENSP00000439703   ENSP00000446368   ENSP00000438491   ENSP00000442193  

    Human Recombinant Protein Products: 
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    Novus Biologicals FKBP4 Proteins
    Novus Biologicals FKBP4 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for FKBP4
    Uscn Proteins for FKBP4

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular NAS--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--


    FKBP4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for FKBP4

    Protein Domains /
    Families
    for FKBP4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FKBP4 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR011990 TPR-like_helical
     IPR023566 PPIase_FKBP
     IPR001440 TPR-1
     IPR001179 PPIase_FKBP_dom
     IPR013026 TPR-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q02790

    ProtoNet protein and cluster: Q02790

    UniProtKB/Swiss-Prot: FKBP4_HUMAN, Q02790
    Domain: The PPIase activity is mainly due to the fisrt PPIase FKBP-type domain (1-138 AA) (By similarity)
    Domain: The C-terminal region (AA 375-458) is required to prevent tubulin polymerization (By similarity)
    Domain: The chaperone activity resides in the C-terminal region, mainly between amino acids 264 and 400 (By similarity)
    Domain: The TPR repeats mediate mitochondrial localization
    Similarity: Contains 2 PPIase FKBP-type domains
    Similarity: Contains 3 TPR repeats


    Function
    for FKBP4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FKBP4_HUMAN, Q02790
    Function: Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unligated steroid
    receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular
    trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By
    similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also
    as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a
    protective role against oxidative stress in mitochondria
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)
    Enzyme regulation: Inhibited by FK506

    Enzyme Number (IUBMB): EC 5.2.1.81 2

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FKBP4
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate FKBP4 (see all 34):
    hsa-miR-4291 hsa-miR-3678-3p hsa-miR-140-5p hsa-miR-642a hsa-miR-4328 hsa-miR-29a hsa-miR-548m hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmid: FKBP4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FKBP4 (see all 4)
    OriGene shRNA RFP: FKBP4
    OriGene siRNA: FKBP4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FKBP4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for FKBP4

    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity IDA11350175
    GO:0005515protein binding IPI12604780
    GO:0005524ATP binding IEA--
    GO:0005525GTP binding IEA--
    GO:0005528FK506 binding TAS1376003


    FKBP4 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for FKBP4:
     Increased Salmonella enterica  

    Animal Models:
         Mouse knock-outs for FKBP4: Fkbp4tm1Dvds Fkbp4tm1Shou
         9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Fkbp4):
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     integument  mortality/aging  renal/urinary system  reproductive system 

    FKBP4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FKBP4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    		Development Glucocorticoid receptor signaling0.27
    		Development_Glucocorticoid receptor signaling0.27
    2Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics
    		Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics1.00
    3Androgen receptor signaling pathway
    		Androgen receptor signaling pathway1.00
    4Coregulation of Androgen receptor activity
    		Coregulation of Androgen receptor activity1.00
    5Glucocorticoid receptor regulatory network
    		Glucocorticoid receptor regulatory network1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for FKBP4
        Development Glucocorticoid receptor signaling

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for FKBP4
        Glucocorticoid Receptor Signaling

    2 GeneGo (Thomson Reuters) Pathways for FKBP4
        Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)
    Development Glucocorticoid receptor signaling

    3 BioSystems Pathways for FKBP4 
        Androgen receptor signaling pathway
    Coregulation of Androgen receptor activity
    Glucocorticoid receptor regulatory network

    1 PharmGKB Pathway for FKBP4
        Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics


    FKBP4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FKBP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/52 Interacting proteins for FKBP4 (Q027902, 3 ENSP000000010084) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    S100A2P290342, 3, ENSP000003576974MINT-7710374 MINT-7710476 MINT-7710432 I2D: score=1 STRING: ENSP00000357697
    HSP90AA1P079002, 3, ENSP000003351534MINT-7710316 MINT-7710476 MINT-7710488 MINT-7710224 I2D: score=3 STRING: ENSP00000335153
    S100A6P067032, 3, ENSP000003577084MINT-7710442 MINT-7710387 MINT-7710488 I2D: score=1 STRING: ENSP00000357708
    YWHAZP631042, 3, ENSP000003095034MINT-3319393 I2D: score=1 STRING: ENSP00000309503
    NR3C1P041503, ENSP000002315094I2D: score=4 STRING: ENSP00000231509
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000413protein peptidyl-prolyl isomerization IDA11350175
    GO:0006457protein folding TAS1279700
    GO:0006463steroid hormone receptor complex assembly IEA--
    GO:0006825copper ion transport IEA--
    GO:0007566embryo implantation IEA--


    FKBP4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FKBP4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FKBP4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for FKBP4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AscomycinCalcineurin phosphatase inhibitor; analog of FK 506 (Cat. No. 3631)[104987-12-4]

    1 HMDB Compound for FKBP4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Dimethyl sulfoxide(methylsulfinyl)methane;Dimethyl sulfoxide (see all 5)67-68-5--
    10/19 Novoseek chemical compound relationships for FKBP4 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tacrolimus 81.8 52 7504525 (4), 8955134 (3), 15697228 (2), 7689858 (2) (see all 30)
    steroid 70.2 37 10718488 (2), 7915146 (2), 2266108 (2), 1279700 (2) (see all 26)
    radicicol 65 1 19581287 (1)
    chlorothalonil 64.5 1 8157642 (1)
    rapamycin 63.9 13 7530727 (3), 8955134 (2), 7689858 (1), 15862952 (1) (see all 8)
    molybdate 60.5 3 9183567 (1), 8157642 (1)
    progesterone 42.5 5 1922029 (2), 7688746 (1), 18771283 (1)
    novobiocin 40.2 1 15209518 (1)
    cyclosporin a 34 3 15862952 (1), 8602846 (1)
    tyrosine 24.9 26 12552015 (4), 11533160 (3), 14711833 (2), 18087261 (2) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about FKBP4 

    Transcripts
    for FKBP4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    REFSEQ mRNAs for FKBP4 gene: 
    NM_002014.3  

    Unigene Cluster for FKBP4:

    FK506 binding protein 4, 59kDa
    Hs.524183  [show with all ESTs]
    Unigene Representative Sequence: NM_002014
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000001008(uc001qkz.3) ENST00000543769 ENST00000540260 ENST00000538622
    ENST00000543037 ENST00000539181 ENST00000544366

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    hsa-miR-4291 hsa-miR-3678-3p hsa-miR-140-5p hsa-miR-642a hsa-miR-4328 hsa-miR-29a hsa-miR-548m hsa-miR-629*
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    Inhib. RNA
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    Primer
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    Additional cDNA sequence: 

    AK024694.1 AK313918.1 BC001786.1 BC002887.2 BC007924.2 M88279.1 

    24/31 DOTS entries (see all 31):

    DT.95162460  DT.318893  DT.100670975  DT.100045862  DT.100670969  DT.91828546  DT.100805434  DT.100670977 
    DT.121115141  DT.40105966  DT.92347167  DT.121115030  DT.91814730  DT.95162448  DT.95162483  DT.100670973 
    DT.121115084  DT.121115190  DT.121115206  DT.121115225  DT.121160235  DT.121168127  DT.121197953  DT.92004655 

    24/547 AceView cDNA sequences (see all 547):

    N32255 AA905094 BP341922 BQ893637 AA923017 CD108680 AI659474 CD365377 
    BX445147 CA454549 BG282197 BM455132 BM824793 BQ772153 BQ575758 BQ920081 
    AI682405 BU196514 CB121212 AI873144 BU629051 BU856857 BE261368 AK024694 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for FKBP4    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                                                  
    SP2:                                                                  


    ECgene alternative splicing isoforms for FKBP4

    Expression
    for FKBP4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FKBP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTGAGCAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See FKBP4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FKBP4

    SOURCE GeneReport for Unigene cluster: Hs.524183

    UniProtKB/Swiss-Prot: FKBP4_HUMAN, Q02790
    Tissue specificity: Widely expressed

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    Orthologs
    for FKBP4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FKBP4 gene from 8/32 species (see all 32)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FKBP41 FK506 binding protein 4, 59kDa 72.71(n)
    77.75(a)    		   418261  NM_001006250.1  NP_001006250.1 
    lizard
    (Anolis carolinensis)    		 Reptilia FKBP46
    		 --
    		 70(a)
    		 1 ↔ 1
    		 5(80577462-80599213)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BU905331.12   -- 73.18(n)    BU905331.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.34732 Danio rerio mRNA similar to FK506 binding protein 4, more 74.02(n)    BC045387.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta FKBP591 , 3 peripheral nervous system development FK506
    binding3
    FK506-binding protein FKBP591    		 44(a)3
    55.8(n)1
    45.77(a)1    		   30E13
    477621  NM_080156.31  NP_524895.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea fkb-61 , 3 FKBP-type peptidyl-prolyl cis-trans
    isomerases3
    Protein FKB-61    		 42(a)3
    50.43(n)1
    43.5(a)1    		   V(20838115-20839280)3
    1803711  NM_075625.41  NP_508026.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ROF21 peptidylprolyl isomerase 49.32(n)
    39.34(a)    		   834913  NM_124233.2  NP_199668.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.111242 Oryza sativa (indica cultivar-group) mRNA for peptidylprolyl more 72.93(n)    AJ557547.1 


    ENSEMBL Gene Tree for FKBP4 (if available)
    TreeFam Gene Tree for FKBP4 (if available) 

    Paralogs
    for FKBP4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FKBP4 gene
    FKBP52  FKBP1A2  FKBP1C2  FKBP82  FKBP62  FKBP1B2  FKBP32  
    10 SIMAP similar genes for FKBP4 using alignment to 5 protein entries:     FKBP4_HUMAN (see all proteins):
    FKBP5    FKBP12-Exip2    FKBP1A    FKBP1C    FKBP1B    FKBP2
    FKBP10    FKBP7    FKBP14    FKBP8

    FKBP4 for paralogs           About GeneDecksing


    5/8 Pseudogenes.org Pseudogenes for FKBP4 (see all 8)
    PGOHUM00000245670 PGOHUM00000236060 PGOHUM00000236088 PGOHUM00000236107 PGOHUM00000236147


    Genomic Variants
    for FKBP4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/224 NCBI SNPs in FKBP4 are shown (see all 224)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1510782401,2
    		--2902235(+) CTTACC/TCCAAA 1 -- us2k10--------
    rs1425503391,2
    		--2902322(+) CGTGCC/TGAACA 1 -- us2k10--------
    rs1468963711,2
    		--2902323(+) GTGCCA/GAACAG 1 -- us2k10--------
    rs1119628941,2
    		C,--2902335(+) TTAAAG/-GGGGG 1 -- us2k11Minor allele frequency- -:0.00CSA 2
    rs785874321,2
    		--2902588(+) CTAAAG/AAGACG 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1919086941,2
    		--2902601(+) TTCATC/TATGGC 1 -- us2k10--------
    rs1115113051,2
    		F--2902652(+) TTTCTG/TCTGCA 1 -- us2k12Minor allele frequency- T:0.50CSA 4
    rs1136587341,2
    		--2902761(+) AATGGC/TGTCCA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1393266621,2
    		--2902813(+) AGTTAC/TTATTG 1 -- us2k10--------
    rs1889378971,2
    		--2902891(+) GGCGGA/CTCATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FKBP4 (2904108 - 2914589 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for FKBP4
         2 CNVs: 66123 4766

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    Disorders / Diseases
    for FKBP4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FKBP4 for disorders           About GeneDecksing

    OMIM gene information: 600611    OMIM disorders: --

    20/32 diseases for FKBP4 (see all 32):    About MalaCards
    open-angle glaucoma    primary open angle glaucoma    acoustic neuroma    facial paralysis
    major depressive disorder    glaucoma    male infertility    refsum disease
    lupus nephritis    nephritis    neuroma    hypospadias
    multiple myeloma    paralysis    infertility    hepatitis b
    breast cancer    in situ carcinoma    myeloma    hepatocellular carcinoma

    2 diseases from the University of Copenhagen DISEASES database for FKBP4:
    Facial paralysis     Acoustic neuroma

    5 Novoseek disease relationships for FKBP4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 56.5 33 8157642 (3), 1922029 (2), 7689858 (2), 11525244 (2) (see all 16)
    breast cancer 6.29 10 10718488 (4), 19584157 (3), 11374893 (2)
    breast carcinoma 0 1 10718488 (1)
    neurological disorders 0 1 15713424 (1)
    tumors 0 3 10718488 (2), 19584157 (1)

    Human Genome Epidemiology (HuGE) Navigator: FKBP4 (5 documents)

    Export disorders for FKBP4 gene to outside databases

    Publications
    for FKBP4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FKBP4 gene, integrated from 9 sources (see all 188):
    (articles sorted by number of sources associating them with FKBP4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes. (PubMed id 1279700)1, 2, 3, 9 Peattie D.A.... Benasutti M. (1992)
    2. 3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex. (PubMed id 15159550)1, 2, 9 Wu B....Rao Z. (2004)
    3. The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52. (PubMed id 9392437)1, 2, 9 Bruner K.L.... Litwack G. (1997)
    4. Peptidyl-prolyl isomerase FKBP52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening. (PubMed id 19945390)1, 2 Shim S....Worley P.F. (2009)
    5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex. (PubMed id 11583998)1, 2 Guo Y.... Voellmy R. (2001)
    8. The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13. (PubMed id 1371107)1, 2 Yem A.W.... Deibel M.R. Jr. (1992)
    9. Characterization of high molecular weight FK-506 binding activities reveals a novel FK-506-binding protein as well as a protein complex. (PubMed id 1383226)1, 2 Wiederrecht G.... Siekierka J.J. (1992)
    10. Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex. (PubMed id 1376003)1, 2 Tai P.-K.K.... Schreiber S.L. (1992)

    External Searches for FKBP4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FKBP4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2288 HGNC: 3720 AceView: FKBP4andMDS028 Ensembl:ENSG00000004478 euGenes: HUgn2288
    ECgene: FKBP4 H-InvDB: FKBP4

    Other Databases showing FKBP4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FKBP4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FKBP4 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt118.shtml

    Intellectual Property
    for FKBP4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FKBP4 gene:
    Search GeneIP for patents involving FKBP4

    GeneCards and IP:
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