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FKBP4 Gene

protein-coding   GIFtS: 70
GCID: GC12P002904

FK506 Binding Protein 4, 59kDa

(Previous name: FK506-binding protein 4 (59kD))
  See FKBP4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FK506 Binding Protein 4, 59kDa1 2     rotamase2
FKBP522 3 5     T-Cell FK506-Binding Protein, 59kD2
FK506-Binding Protein 4 (59kD)1 2     52 KDa FK506-Binding Protein3
51 KDa FK506-Binding Protein2 3     52 KDa FKBP3
FKBP512 3     59 KDa Immunophilin3
FKBP592 3     FKBP-43
HBI2 3     FKBP-523
EC 5.2.1.83 8     Rotamase3
Hsp562     FK506-Binding Protein 43
PPIase2     HSP-Binding Immunophilin3
HSP Binding Immunophilin2     Immunophilin FKBP523
p522     p593
Peptidyl-Prolyl Cis-Trans Isomerase FKBP42     PPIase FKBP43
Peptidylprolyl Cis-Trans Isomerase2     

External Ids:    HGNC: 37201   Entrez Gene: 22882   Ensembl: ENSG000000044787   OMIM: 6006115   UniProtKB: Q027903   

Export aliases for FKBP4 gene to outside databases

Previous GC identifers: GC12P002776 GC12P002797 GC12P002774 GC12P002764


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FKBP4 Gene:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in
immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is
a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and
functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have
immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays
an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to
associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and
hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid
hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in
a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is
thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome
contains several non-transcribed pseudogenes similar to this gene. (provided by RefSeq, Sep 2008)

GeneCards Summary for FKBP4 Gene:
FKBP4 (FK506 binding protein 4, 59kDa) is a protein-coding gene. Diseases associated with FKBP4 include facial paralysis, and in situ carcinoma. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and GTP binding. An important paralog of this gene is FKBP5.

UniProtKB/Swiss-Prot: FKBP4_HUMAN, Q02790
Function: Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors
heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular
trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments.
The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a
regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a
protective role against oxidative stress in mitochondria

Gene Wiki entry for FKBP4 (FKBP52) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_009759.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the FKBP4 gene promoter:
         Bach1   SRF   Sp1   SRF (504 AA)   FAC1   CP2   FOXJ2 (long isoform)   HSF2   FOXJ2   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFKBP4 promoter sequence
   Search Chromatin IP Primers for FKBP4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FKBP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.33   Ensembl cytogenetic band:  12p13.33   HGNC cytogenetic band: 12p13.33

FKBP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FKBP4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P002904:  view genomic region     (about GC identifiers)

Start:
2,904,108 bp from pter      End:
2,914,589 bp from pter
Size:
10,482 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FKBP4_HUMAN, Q02790 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase FKBP4  
Size: 459 amino acids; 51805 Da
Subunit: Homodimer (By similarity). Associates with HSP90AA1 and HSP70 in steroid hormone receptor complexes. Also
interacts with peroxisomal phytanoyl-CoA alpha-hydroxylase (PHYH). Interacts with NR3C1 and dynein. Interacts
with HSF1 in the HSP90 complex. Associates with tubulin. Interacts with MAPT/TAU. Interacts (via TPR domain) with
S100A1, S100A2 and S100A6; the interaction is Ca(2+) dependent. Interaction with S100A1 and S100A2 (but not with
S100A6) leads to inhibition of FKBP4-HSP90 interaction. Interacts with dynein; causes partially NR3C1 transport
to the nucleus
Selected PDB 3D structures from and Proteopedia for FKBP4 (see all 9):
1N1A (3D)        1P5Q (3D)        1Q1C (3D)        1QZ2 (3D)        4DRJ (3D)        4LAV (3D)    
Secondary accessions: D3DUQ1 Q9UCP1 Q9UCV7

Explore the universe of human proteins at neXtProt for FKBP4: NX_Q02790

Explore proteomics data for FKBP4 at MOPED

Post-translational modifications: 

  • Phosphorylation by CK2 results in loss of HSP90 binding activity (By similarity)1
  • Ubiquitination2 at Lys28, Lys76, Lys83, Lys88, Lys222, Lys244, Lys250, Lys354, Lys378, Lys409
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for FKBP4 (Q02790) (see all 12)
     KIVSWLE  IPPNATL  GSPPKIP  TRGEGYA 


    See FKBP4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002005.1  
    ENSEMBL proteins: 
     ENSP00000001008   ENSP00000439703   ENSP00000446368   ENSP00000438491   ENSP00000442193  
    Reactome Protein details: Q02790

    FKBP4 Human Recombinant Protein Products:

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    ProSpec Recombinant Protein for FKBP4
    Cloud-Clone Corp. Proteins for FKBP4

     
    Search eBioscience for Proteins for FKBP4 

     
    antibodies-online proteins for FKBP4 (25 products) 

     
    antibodies-online peptides for FKBP4

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    antibodies-online kits for FKBP4 (11 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TTC: Tetratricopeptide (TTC) repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR011990 TPR-like_helical
     IPR023566 PPIase_FKBP
     IPR001440 TPR_1
     IPR001179 PPIase_FKBP_dom
     IPR013026 TPR-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q02790

    ProtoNet protein and cluster: Q02790

    UniProtKB/Swiss-Prot: FKBP4_HUMAN, Q02790
    Domain: The PPIase activity is mainly due to the fisrt PPIase FKBP-type domain (1-138 AA) (By similarity)
    Domain: The C-terminal region (AA 375-458) is required to prevent tubulin polymerization (By similarity)
    Domain: The chaperone activity resides in the C-terminal region, mainly between amino acids 264 and 400 (By
    similarity)
    Domain: The TPR repeats mediate mitochondrial localization
    Similarity: Contains 2 PPIase FKBP-type domains
    Similarity: Contains 3 TPR repeats


    Find genes that share domains with FKBP4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FKBP4_HUMAN, Q02790
    Function: Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors
    heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular
    trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments.
    The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a
    regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a
    protective role against oxidative stress in mitochondria
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)
    Enzyme regulation: Inhibited by FK506

         Enzyme Number (IUBMB): EC 5.2.1.81 2

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity IDA11350175
    GO:0005515protein binding IPI12604780
    GO:0005524ATP binding IEA--
    GO:0005525GTP binding IEA--
    GO:0005528FK506 binding TAS1376003
         
    Find genes that share ontologies with FKBP4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FKBP4:
     Increased Salmonella enterica  

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fkbp4):
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 
     integument  mortality/aging  renal/urinary system  reproductive system 

    Find genes that share phenotypes with FKBP4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FKBP4: Fkbp4tm1Dvds Fkbp4tm1Shou

       genOway: Develop your customized and physiologically relevant rodent model for FKBP4

    miRNA
    Products:
        
    miRTarBase miRNAs that target FKBP4:
    hsa-mir-484 (MIRT041945), hsa-mir-423-5p (MIRT038093), hsa-mir-92a-3p (MIRT049584), hsa-mir-197-3p (MIRT048140), hsa-mir-328-3p (MIRT043773), hsa-mir-877-3p (MIRT037008), hsa-mir-18a-3p (MIRT040812), hsa-mir-615-3p (MIRT039622), hsa-mir-149-5p (MIRT045461), hsa-mir-744-5p (MIRT037530), hsa-mir-23a-3p (MIRT050423), hsa-mir-760 (MIRT036772), hsa-mir-99b-3p (MIRT038526), hsa-mir-92b-3p (MIRT040589)

    Block miRNA regulation of human, mouse, rat FKBP4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FKBP4 (see all 34):
    hsa-miR-4291 hsa-miR-3678-3p hsa-miR-140-5p hsa-miR-642a hsa-miR-4328 hsa-miR-29a hsa-miR-548m hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidFKBP4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FKBP4

    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBP4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FKBP4_HUMAN, Q02790: Cytoplasm, cytosol (By similarity). Mitochondrion. Nucleus. Cytoplasm, cytoskeleton (By
    similarity). Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid
    receptor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    cytosol4
    cytoskeleton3
    peroxisome2
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--

    Find genes that share ontologies with FKBP4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FKBP4 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    Glucocorticoid Receptor Signaling0.43
    2Development Endothelin 1 EDNRA signaling
    Estrogen signaling pathway0.34
    3COPI Mediated Transport
    Cholesterol and Sphingolipids transport Transport from Golgi and ER to the apical membrane normal and CF 0.31
    4Glucocorticoid receptor regulatory network
    Glucocorticoid receptor regulatory network
    5Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics
    Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics


    Find genes that share SuperPaths with FKBP4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for FKBP4
        Glucocorticoid Receptor Signaling

    2 GeneGo (Thomson Reuters) Pathways for FKBP4
        Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)
    Development Glucocorticoid receptor signaling

    3 BioSystems Pathways for FKBP4
        Androgen receptor signaling pathway
    Glucocorticoid receptor regulatory network
    Coregulation of Androgen receptor activity


    1 Reactome Pathway for FKBP4
        Attenuation phase

    1 PharmGKB Pathway for FKBP4
        Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics

    1 Kegg Pathway  (Kegg details for FKBP4):
        Estrogen signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FKBP4
    Interactions:

        GeneGlobe Interaction Network for FKBP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FKBP4 (Q027901, 2, 3 ENSP000000010084) via UniProtKB, MINT, STRING, and/or I2D (see all 90)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    S100A2P290341, 2, 3, ENSP000003576974EBI-1047444,EBI-752230 MINT-7710374 MINT-7710476 MINT-7710432 I2D: score=1 STRING: ENSP00000357697
    HSP90AA1P079001, 2, 3, ENSP000003351534EBI-1047444,EBI-296047 MINT-7710316 MINT-7710476 MINT-7710488 MINT-7710224 I2D: score=3 STRING: ENSP00000335153
    S100A6P067031, 2, 3, ENSP000003577084EBI-1047444,EBI-352877 MINT-7710442 MINT-7710387 MINT-7710488 I2D: score=1 STRING: ENSP00000357708
    YWHAZP631042, 3, ENSP000003095034MINT-3319393 I2D: score=1 STRING: ENSP00000309503
    NR3C1P041503, ENSP000002315094I2D: score=4 STRING: ENSP00000231509
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000413protein peptidyl-prolyl isomerization IDA11350175
    GO:0006457protein folding TAS1279700
    GO:0006463steroid hormone receptor complex assembly IEA--
    GO:0006825copper ion transport IEA--
    GO:0007566embryo implantation IEA--

    Find genes that share ontologies with FKBP4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FKBP4

    1 HMDB Compound for FKBP4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Dimethyl sulfoxide(methylsulfinyl)methane;Dimethyl sulfoxide (see all 5)67-68-5--

    Selected Novoseek inferred chemical compound relationships for FKBP4 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tacrolimus 81.8 52 7504525 (4), 8955134 (3), 15697228 (2), 7689858 (2) (see all 30)
    steroid 70.2 37 10718488 (2), 7915146 (2), 2266108 (2), 1279700 (2) (see all 26)
    radicicol 65 1 19581287 (1)
    chlorothalonil 64.5 1 8157642 (1)
    rapamycin 63.9 13 7530727 (3), 8955134 (2), 7689858 (1), 15862952 (1) (see all 8)
    molybdate 60.5 3 9183567 (1), 8157642 (1)
    progesterone 42.5 5 1922029 (2), 7688746 (1), 18771283 (1)
    novobiocin 40.2 1 15209518 (1)
    cyclosporin a 34 3 15862952 (1), 8602846 (1)
    tyrosine 24.9 26 12552015 (4), 11533160 (3), 14711833 (2), 18087261 (2) (see all 7)



    Find genes that share compounds with FKBP4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FKBP4 gene: 
    NM_002014.3  

    Unigene Cluster for FKBP4:

    FK506 binding protein 4, 59kDa
    Hs.524183  [show with all ESTs]
    Unigene Representative Sequence: NM_002014
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000001008(uc001qkz.3) ENST00000543769 ENST00000540260 ENST00000538622
    ENST00000543037 ENST00000539181 ENST00000544366
    miRNA
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    hsa-miR-4291 hsa-miR-3678-3p hsa-miR-140-5p hsa-miR-642a hsa-miR-4328 hsa-miR-29a hsa-miR-548m hsa-miR-629*
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      QuantiTect SYBR Green Assays in human, mouse, rat FKBP4
      QuantiFast Probe-based Assays in human, mouse, rat FKBP4

    Additional mRNA sequence: 

    AK024694.1 AK313918.1 BC001786.1 BC002887.2 BC007924.2 M88279.1 

    Selected DOTS entries (see all 31):

    DT.95162460  DT.318893  DT.100670975  DT.100045862  DT.100670969  DT.91828546  DT.100805434  DT.100670977 
    DT.121115141  DT.40105966  DT.92347167  DT.121115030  DT.91814730  DT.95162448  DT.95162483  DT.100670973 
    DT.121115084  DT.121115190  DT.121115206  DT.121115225  DT.121160235  DT.121168127  DT.121197953  DT.92004655 

    Selected AceView cDNA sequences (see all 547):

    BM788997 BX097664 AY599883 AI873144 BF982262 AI863052 BQ935353 BQ882941 
    BQ962051 BE794700 BI906768 NM_002014 BQ690619 BQ063130 BQ018511 F32234 
    BU542103 BQ920081 BQ686589 AI682405 BM970918 BM824793 BQ651912 BM792803 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for FKBP4    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                                                  
    SP2:                                                                  


    ECgene alternative splicing isoforms for FKBP4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    FKBP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTGAGCAAT
    FKBP4 Expression
    About this image


    FKBP4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Colon (Gastrointestinal Tract)
     
     Kidney (Urinary System)
    FKBP4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FKBP4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524183

    UniProtKB/Swiss-Prot: FKBP4_HUMAN, Q02790
    Tissue specificity: Widely expressed

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FKBP4 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fkbp41 , 5 FK506 binding protein 41, 5 87.48(n)1
    89.96(a)1
      6 (63.00 cM)5
    142281  NM_010219.31  NP_034349.11 
     1284297355 
    chicken
    (Gallus gallus)
    Aves FKBP41 FK506 binding protein 4, 59kDa 72.78(n)
    77.75(a)
      418261  NM_001006250.1  NP_001006250.1 
    lizard
    (Anolis carolinensis)
    Reptilia FKBP46
    FK506 binding protein 4, 59kDa
    70(a)
    1 ↔ 1
    5(80577461-80599213)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU905331.12   -- 73.18(n)    BU905331.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.34732 Danio rerio mRNA similar to FK506 binding protein 4, more 74.02(n)    BC045387.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta FKBP591 , 3 peripheral nervous system development
    FK506 binding3
    FK506-binding protein FKBP591
    44(a)3
    55.86(n)1
    46.58(a)1
      30E13
    477621  NM_080156.41  NP_524895.21 
    worm
    (Caenorhabditis elegans)
    Secernentea fkb-61 , 3 FKBP-type peptidyl-prolyl cis-trans
    isomerases3
    fkb-61
    42(a)3
    50.28(n)1
    43.5(a)1
      V(20838115-20839280)3
    1803711  NM_075625.51  NP_508026.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FPR16
    Peptidyl-prolyl cis-trans isomerase (PPIase), bind...
    46(a)
    1 → many
    XIV(371882-372226) YNL135C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ROF11 ROF1 48.96(n)
    39.84(a)
      822117  NM_113429.4  NP_189160.3 
    rice
    (Oryza sativa)
    Liliopsida Os.111242 Oryza sativa (indica cultivar-group) mRNA for peptidylprolyl more 72.93(n)    AJ557547.1 


    ENSEMBL Gene Tree for FKBP4 (if available)
    TreeFam Gene Tree for FKBP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FKBP4 gene
    FKBP52  FKBP1A2  FKBP1C2  FKBP82  FKBP62  FKBP1B2  FKBP32  
    10 SIMAP similar genes for FKBP4 using alignment to 5 protein entries:     FKBP4_HUMAN (see all proteins):
    FKBP5    FKBP12-Exip2    FKBP1A    FKBP1C    FKBP1B    FKBP2
    FKBP10    FKBP7    FKBP14    FKBP8

    Find genes that share paralogs with FKBP4           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for FKBP4 (see all 8)
    PGOHUM00000245670 PGOHUM00000236060 PGOHUM00000236088 PGOHUM00000236107 PGOHUM00000236147


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for FKBP4 (see all 309)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1510782401,2
    --2902235(+) CTTACC/TCCAAA 1 -- us2k10--------
    rs1425503391,2
    --2902322(+) CGTGCC/TGAACA 1 -- us2k10--------
    rs1468963711,2
    --2902323(+) GTGCCA/GAACAG 1 -- us2k10--------
    rs1119628941,2
    C--2902335(+) TTAAAG/-GGGGG 1 -- us2k11Minor allele frequency- -:0.00CSA 2
    rs785874321,2
    F--2902588(+) CTAAAG/AAGACG 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1919086941,2
    --2902601(+) TTCATC/TATGGC 1 -- us2k10--------
    rs1115113051,2
    F--2902652(+) TTTCTG/TCTGCA 1 -- us2k12Minor allele frequency- T:0.50CSA 4
    rs1136587341,2
    F--2902761(+) AATGGC/TGTCCA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1393266621,2
    --2902813(+) AGTTAC/TTATTG 1 -- us2k10--------
    rs1889378971,2
    --2902891(+) GGCGGA/CTCATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FKBP4 (2904108 - 2914589 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FKBP4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv26689CNV Loss19812545
    dgv19n68CNV Loss17160897
    nsv826195CNV Gain20364138
    nsv826194CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FKBP4
    DNA2.0 Custom Variant and Variant Library Synthesis for FKBP4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600611    OMIM disorders: --

    2 diseases for FKBP4:    
    About MalaCards
    facial paralysis    in situ carcinoma

    2 diseases from the University of Copenhagen DISEASES database for FKBP4:
    Facial paralysis     Acoustic neuroma

    Find genes that share disorders with FKBP4           About GenesLikeMe

    5 Novoseek inferred disease relationships for FKBP4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 56.5 33 8157642 (3), 1922029 (2), 7689858 (2), 11525244 (2) (see all 16)
    breast cancer 6.29 10 10718488 (4), 19584157 (3), 11374893 (2)
    breast carcinoma 0 1 10718488 (1)
    neurological disorders 0 1 15713424 (1)
    tumors 0 3 10718488 (2), 19584157 (1)

    Genetic Association Database (GAD): FKBP4
    Human Genome Epidemiology (HuGE) Navigator: FKBP4 (5 documents)

    Export disorders for FKBP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FKBP4 gene, integrated from 10 sources (see all 199):
    (articles sorted by number of sources associating them with FKBP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes. (PubMed id 1279700)1, 2, 3, 9 Peattie D.A.... Benasutti M. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    2. Studies of a co-chaperone of the androgen receptor, FKBP52, as candidate for hypospadias. (PubMed id 17343741)1, 4, 9 Beleza-Meireles A....NordenskjAPld A. (amp 2007)
    3. 3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex. (PubMed id 15159550)1, 2, 9 Wu B.... Rao Z. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    4. S100 proteins regulate the interaction of Hsp90 with cyclophilin 40 and FKBP52 through their tetratricopeptide repeats. (PubMed id 20188096)1, 2, 9 Shimamoto S.... Kobayashi R. (FEBS Lett. 2010)
    5. Assessment of SNPs associated with the human glucocorticoid receptor in primary open-angle glaucoma and steroid responders. (PubMed id 20376328)1, 4, 9 Fingert J.H....Clark A.F. (Mol. Vis. 2010)
    6. The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52. (PubMed id 9392437)1, 2, 9 Bruner K.L.... Litwack G. (Recept. Signal Transduct. 1997)
    7. Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. (PubMed id 19197348)1, 4 Lowe J.K....Friedman J.M. (PLoS Genet. 2009)
    8. Peptidyl-prolyl isomerase FKBP52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening. (PubMed id 19945390)1, 2 Shim S.... Worley P.F. (Neuron 2009)
    9. The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids. (PubMed id 19254810)1, 4 Hawkins G.A....Bleecker E.R. (J. Allergy Clin. Immunol. 2009)
    10. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2288 HGNC: 3720 AceView: FKBP4andMDS028 Ensembl:ENSG00000004478 euGenes: HUgn2288
    ECgene: FKBP4 Kegg: 2288 H-InvDB: FKBP4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FKBP4 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/118

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FKBP4 gene:
    Search GeneIP for patents involving FKBP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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