Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FKBP4 Gene

Aliases for FKBP4 Gene

  • FK506 Binding Protein 4, 59kDa 2 3
  • FKBP52 3 4 6
  • FK506-Binding Protein 4 (59kD) 2 3
  • 51 KDa FK506-Binding Protein 3 4
  • EC 5.2.1.8 4 64
  • Rotamase 3 4
  • FKBP51 3 4
  • FKBP59 3 4
  • HBI 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase FKBP4 3
  • T-Cell FK506-Binding Protein, 59kD 3
  • Peptidylprolyl Cis-Trans Isomerase 3
  • 52 KDa FK506-Binding Protein 4
  • HSP Binding Immunophilin 3
  • HSP-Binding Immunophilin 4
  • FK506-Binding Protein 4 4
  • 59 KDa Immunophilin 4
  • Immunophilin FKBP52 4
  • PPIase FKBP4 4
  • 52 KDa FKBP 4
  • FKBP-52 4
  • PPIASE 3
  • FKBP-4 4
  • Hsp56 3
  • P52 3
  • P59 4

External Ids for FKBP4 Gene

Summaries for FKBP4 Gene

Entrez Gene Summary for FKBP4 Gene

  • The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]

GeneCards Summary for FKBP4 Gene

FKBP4 (FK506 Binding Protein 4, 59kDa) is a Protein Coding gene. Diseases associated with FKBP4 include facial paralysis and ocular hypertension. Among its related pathways are Glucocorticoid receptor regulatory network and PEDF Induced Signaling. GO annotations related to this gene include GTP binding and peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is FKBP1A.

UniProtKB/Swiss-Prot for FKBP4 Gene

  • Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.

Gene Wiki entry for FKBP4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBP4 Gene

Genomics for FKBP4 Gene

Genomic Location for FKBP4 Gene

Start:
2,794,942 bp from pter
End:
2,805,423 bp from pter
Size:
10,482 bases
Orientation:
Plus strand

Genomic View for FKBP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FKBP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP4 Gene

Regulatory Elements for FKBP4 Gene

Proteins for FKBP4 Gene

  • Protein details for FKBP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02790-FKBP4_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP4
    Protein Accession:
    Q02790
    Secondary Accessions:
    • D3DUQ1
    • Q9UCP1
    • Q9UCV7

    Protein attributes for FKBP4 Gene

    Size:
    459 amino acids
    Molecular mass:
    51805 Da
    Quaternary structure:
    • Homodimer (By similarity). Associates with HSP90AA1 and HSP70 in steroid hormone receptor complexes. Also interacts with peroxisomal phytanoyl-CoA alpha-hydroxylase (PHYH). Interacts with NR3C1 and dynein. Interacts with HSF1 in the HSP90 complex. Associates with tubulin. Interacts with MAPT/TAU. Interacts (via TPR domain) with S100A1, S100A2 and S100A6; the interaction is Ca(2+) dependent. Interaction with S100A1 and S100A2 (but not with S100A6) leads to inhibition of FKBP4-HSP90 interaction. Interacts with dynein; causes partially NR3C1 transport to the nucleus.

    Three dimensional structures from OCA and Proteopedia for FKBP4 Gene

neXtProt entry for FKBP4 Gene

Proteomics data for FKBP4 Gene at MOPED

Post-translational modifications for FKBP4 Gene

  • Phosphorylation by CK2 results in loss of HSP90 binding activity.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys28, Lys76, Lys83, Lys88, Lys222, Lys244, Lys250, Lys354, Lys378, and Lys409

Other Protein References for FKBP4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for FKBP4 Gene

Gene Families for FKBP4 Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for FKBP4 Gene

UniProtKB/Swiss-Prot:

FKBP4_HUMAN
Domain:
  • The PPIase activity is mainly due to the fisrt PPIase FKBP-type domain (1-138 AA).:
    • Q02790
  • The C-terminal region (AA 375-458) is required to prevent tubulin polymerization.:
    • Q02790
  • The chaperone activity resides in the C-terminal region, mainly between amino acids 264 and 400.:
    • Q02790
  • The TPR repeats mediate mitochondrial localization:
    • Q02790
  • Contains 2 PPIase FKBP-type domains.:
    • Q02790
Similarity:
  • Contains 3 TPR repeats.:
    • Q02790
genes like me logo Genes that share domains with FKBP4: view

Function for FKBP4 Gene

Molecular function for FKBP4 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Peptidylproline (omega=180) = peptidylproline (omega=0)
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by FK506.
UniProtKB/Swiss-Prot Function: Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.

Enzyme Numbers (IUBMB) for FKBP4 Gene

Gene Ontology (GO) - Molecular Function for FKBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IDA 11350175
GO:0005515 protein binding IPI 12604780
GO:0005524 ATP binding IEA --
GO:0005525 GTP binding IEA --
GO:0005528 FK506 binding TAS 1376003
genes like me logo Genes that share ontologies with FKBP4: view
genes like me logo Genes that share phenotypes with FKBP4: view

Animal Models for FKBP4 Gene

MGI Knock Outs for FKBP4:

No data available for Transcription Factor Targeting and HOMER Transcription for FKBP4 Gene

Localization for FKBP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP4 Gene

Cytoplasm, cytosol. Mitochondrion. Nucleus. Cytoplasm, cytoskeleton. Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FKBP4 Gene COMPARTMENTS Subcellular localization image for FKBP4 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 4
cytoskeleton 3
peroxisome 2
extracellular 1

Gene Ontology (GO) - Cellular Components for FKBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005789 endoplasmic reticulum membrane IBA --
genes like me logo Genes that share ontologies with FKBP4: view

Pathways for FKBP4 Gene

genes like me logo Genes that share pathways with FKBP4: view

Gene Ontology (GO) - Biological Process for FKBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0006457 protein folding TAS 1279700
GO:0006463 steroid hormone receptor complex assembly IEA --
GO:0006825 copper ion transport IEA --
GO:0007566 embryo implantation IEA --
genes like me logo Genes that share ontologies with FKBP4: view

Compounds for FKBP4 Gene

(1) HMDB Compounds for FKBP4 Gene

Compound Synonyms Cas Number PubMed IDs
Dimethyl sulfoxide
  • (methylsulfinyl)methane
67-68-5

(19) Novoseek inferred chemical compound relationships for FKBP4 Gene

Compound -log(P) Hits PubMed IDs
tacrolimus 81.8 41
steroid 70.2 31
radicicol 65 1
chlorothalonil 64.5 1
rapamycin 63.9 11
genes like me logo Genes that share compounds with FKBP4: view

Transcripts for FKBP4 Gene

Unigene Clusters for FKBP4 Gene

FK506 binding protein 4, 59kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2:

Relevant External Links for FKBP4 Gene

GeneLoc Exon Structure for
FKBP4
ECgene alternative splicing isoforms for
FKBP4

Expression for FKBP4 Gene

mRNA expression in normal human tissues for FKBP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FKBP4 Gene

SOURCE GeneReport for Unigene cluster for FKBP4 Gene Hs.524183

mRNA Expression by UniProt/SwissProt for FKBP4 Gene

Q02790-FKBP4_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with FKBP4: view

Orthologs for FKBP4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FKBP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FKBP4 36
  • 99.56 (n)
  • 99.35 (a)
FKBP4 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FKBP4 36
  • 86.49 (n)
  • 88.67 (a)
FKBP4 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FKBP4 36
  • 90.92 (n)
  • 91.72 (a)
FKBP4 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fkbp4 36
  • 87.48 (n)
  • 89.96 (a)
Fkbp4 16
Fkbp4 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FKBP4 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FKBP4 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fkbp4 36
  • 87.92 (n)
  • 90.17 (a)
chicken
(Gallus gallus)
Aves FKBP4 36
  • 72.78 (n)
  • 77.75 (a)
FKBP4 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FKBP4 37
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6060 36
zebrafish
(Danio rerio)
Actinopterygii Dr.3473 36
fkbp4 36
  • 65.87 (n)
  • 64.92 (a)
fkbp4 37
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009347 36
  • 52.32 (n)
  • 43.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta FKBP59 36
  • 55.86 (n)
  • 46.58 (a)
FKBP59 37
  • 42 (a)
OneToMany
FKBP59 38
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea fkb-6 36
  • 50.28 (n)
  • 43.5 (a)
fkb-6 37
  • 42 (a)
OneToMany
fkb-6 38
  • 42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPR1 37
  • 46 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7502 36
thale cress
(Arabidopsis thaliana)
eudicotyledons ROF1 36
  • 48.96 (n)
  • 39.84 (a)
corn
(Zea mays)
Liliopsida Zm.8824 36
rice
(Oryza sativa)
Liliopsida Os.11124 36
Os08g0525600 36
  • 48.87 (n)
  • 39.85 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.9887 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 51 (a)
ManyToMany
Species with no ortholog for FKBP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for FKBP4 Gene

ENSEMBL:
Gene Tree for FKBP4 (if available)
TreeFam:
Gene Tree for FKBP4 (if available)

Paralogs for FKBP4 Gene

Paralogs for FKBP4 Gene

Selected SIMAP similar genes for FKBP4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FKBP4: view

Variants for FKBP4 Gene

Sequence variations from dbSNP and Humsavar for FKBP4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1042233 -- 2,803,220(+) GCAAC(A/C)CGGCA reference, missense
rs1042261 -- 2,803,314(+) ACTCC(A/C)CCCTG utr-variant-3-prime
rs1042536 -- 2,803,869(+) AGCCT(C/T)TTCTC utr-variant-3-prime
rs1062478 -- 2,798,782(+) GACTC(A/G)CGGTG missense, reference
rs1803815 -- 2,803,806(+) CCTGT(C/T)CTGGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FKBP4 Gene

Variant ID Type Subtype PubMed ID
dgv19n68 CNV Loss 17160897
nsv826194 CNV Gain 20364138
nsv826195 CNV Gain 20364138
esv26689 CNV Loss 19812545

Relevant External Links for FKBP4 Gene

HapMap Linkage Disequilibrium report
FKBP4

Disorders for FKBP4 Gene

(2) University of Copenhagen DISEASES for FKBP4 Gene

(5) Novoseek inferred disease relationships for FKBP4 Gene

Disease -log(P) Hits PubMed IDs
shock 56.5 22
breast cancer 6.29 9
breast carcinoma 0 1
neurological disorders 0 1
tumors 0 3

Relevant External Links for FKBP4

Genetic Association Database (GAD)
FKBP4
Human Genome Epidemiology (HuGE) Navigator
FKBP4
genes like me logo Genes that share disorders with FKBP4: view

No data available for UniProtKB/Swiss-Prot for FKBP4 Gene

Publications for FKBP4 Gene

  1. Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes. (PMID: 1279700) Peattie D.A. … Benasutti M. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4 23
  2. The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52. (PMID: 9392437) Bruner K.L. … Litwack G. (Recept. Signal Transduct. 1997) 3 4 23
  3. 3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex. (PMID: 15159550) Wu B. … Rao Z. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 23
  4. Studies of a co-chaperone of the androgen receptor, FKBP52, as candidate for hypospadias. (PMID: 17343741) Beleza-Meireles A. … NordenskjAPld A. (Reprod. Biol. Endocrinol. 2007) 3 23 49
  5. S100 proteins regulate the interaction of Hsp90 with cyclophilin 40 and FKBP52 through their tetratricopeptide repeats. (PMID: 20188096) Shimamoto S. … Kobayashi R. (FEBS Lett. 2010) 3 4 23

Products for FKBP4 Gene

Sources for FKBP4 Gene

Back to Top

Content