Aliases for FKBP3 Gene
External Ids for FKBP3 Gene
Previous GeneCards Identifiers for FKBP3 Gene
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008]
GeneCards Summary for FKBP3 Gene
FKBP3 (FK506 Binding Protein 3) is a Protein Coding gene. Among its related pathways are Integrated Pancreatic Cancer Pathway and Signaling events mediated by HDAC Class I. GO annotations related to this gene include poly(A) RNA binding and peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is FKBP4.
UniProtKB/Swiss-Prot for FKBP3 Gene
FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins.