Aliases for FKBP3 Gene
External Ids for FKBP3 Gene
Previous GeneCards Identifiers for FKBP3 Gene
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008]
GeneCards Summary for FKBP3 Gene
FKBP3 (FK506 Binding Protein 3) is a Protein Coding gene. Among its related pathways are Signaling events mediated by HDAC Class I. GO annotations related to this gene include poly(A) RNA binding and peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is FKBP4.
UniProtKB/Swiss-Prot for FKBP3 Gene
FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins.