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Aliases for FKBP3 Gene

Aliases for FKBP3 Gene

  • FK506 Binding Protein 3, 25kDa 2 3
  • FKBP25 3 4 6
  • Rapamycin-Selective 25 KDa Immunophilin 3 4
  • FK506-Binding Protein 3 (25kD) 2 3
  • 25 KDa FK506-Binding Protein 3 4
  • Immunophilin FKBP25 3 4
  • PPIase FKBP3 3 4
  • 25 KDa FKBP 3 4
  • Rotamase 3 4
  • FKBP-25 3 4
  • FKBP-3 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase FKBP3 3
  • FK506-Binding Protein 25, T-Cell 3
  • Rapamycin Binding Protein 3
  • FK506-Binding Protein 3 4
  • EC 5.2.1.8 4
  • PPIASE 3

External Ids for FKBP3 Gene

Previous GeneCards Identifiers for FKBP3 Gene

  • GC14M042906
  • GC14M039381
  • GC14M043574
  • GC14M043575
  • GC14M044654
  • GC14M045584
  • GC14M025695

Summaries for FKBP3 Gene

Entrez Gene Summary for FKBP3 Gene

  • The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008]

GeneCards Summary for FKBP3 Gene

FKBP3 (FK506 Binding Protein 3, 25kDa) is a Protein Coding gene. Among its related pathways are Integrated Pancreatic Cancer Pathway and Signaling events mediated by HDAC Class I. GO annotations related to this gene include receptor activity and FK506 binding. An important paralog of this gene is FKBP1A.

UniProtKB/Swiss-Prot for FKBP3 Gene

  • FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins

Gene Wiki entry for FKBP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBP3 Gene

Genomics for FKBP3 Gene

Regulatory Elements for FKBP3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FKBP3 Gene

Start:
45,115,599 bp from pter
End:
45,135,319 bp from pter
Size:
19,721 bases
Orientation:
Minus strand

Genomic View for FKBP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FKBP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP3 Gene

Proteins for FKBP3 Gene

  • Protein details for FKBP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00688-FKBP3_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP3
    Protein Accession:
    Q00688
    Secondary Accessions:
    • B2R4Q9
    • Q14317

    Protein attributes for FKBP3 Gene

    Size:
    224 amino acids
    Molecular mass:
    25177 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA58474.1; Type=Frameshift; Positions=197; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FKBP3 Gene

neXtProt entry for FKBP3 Gene

Proteomics data for FKBP3 Gene at MOPED

Post-translational modifications for FKBP3 Gene

  • Ubiquitination at Lys27
  • Modification sites at PhosphoSitePlus

Other Protein References for FKBP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FKBP3 Gene

Domains for FKBP3 Gene

Protein Domains for FKBP3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FKBP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q00688

UniProtKB/Swiss-Prot:

FKBP3_HUMAN :
  • Q00688
Domain:
  • Contains 1 PPIase FKBP-type domain.
Family:
  • Belongs to the FKBP-type PPIase family.
genes like me logo Genes that share domains with FKBP3: view

No data available for Gene Families for FKBP3 Gene

Function for FKBP3 Gene

Molecular function for FKBP3 Gene

GENATLAS Biochemistry: FK506-binding protein 3,T cell binding protein FKBP-25 for the immunosuppressive agents FK506-rapamycin ,with intrinsic peptidyl-prolyl cis-trans isomerase activity
UniProtKB/Swiss-Prot CatalyticActivity: Peptidylproline (omega=180) = peptidylproline (omega=0)
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited preferentially by rapamycin over FK506
UniProtKB/Swiss-Prot Function: FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins

Enzyme Numbers (IUBMB) for FKBP3 Gene

Gene Ontology (GO) - Molecular Function for FKBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0004872 receptor activity TAS 1374240
GO:0005515 protein binding IPI 19166840
GO:0005528 FK506 binding IBA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with FKBP3: view

Animal Model Products

CRISPR Products

miRNA for FKBP3 Gene

miRTarBase miRNAs that target FKBP3

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FKBP3 Gene

Localization for FKBP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FKBP3 Gene COMPARTMENTS Subcellular localization image for FKBP3 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for FKBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005789 endoplasmic reticulum membrane IBA --
genes like me logo Genes that share ontologies with FKBP3: view

Pathways for FKBP3 Gene

genes like me logo Genes that share pathways with FKBP3: view

Pathways by source for FKBP3 Gene

Gene Ontology (GO) - Biological Process for FKBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IBA --
GO:0006457 protein folding --
GO:0061077 chaperone-mediated protein folding IBA --
genes like me logo Genes that share ontologies with FKBP3: view

Compounds for FKBP3 Gene

(2) Novoseek inferred chemical compound relationships for FKBP3 Gene

Compound -log(P) Hits PubMed IDs
tacrolimus 68.6 8
rapamycin 61.3 7
genes like me logo Genes that share compounds with FKBP3: view

Transcripts for FKBP3 Gene

Unigene Clusters for FKBP3 Gene

FK506 binding protein 3, 25kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FKBP3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP3 Gene

No ASD Table

Relevant External Links for FKBP3 Gene

GeneLoc Exon Structure for
FKBP3
ECgene alternative splicing isoforms for
FKBP3

Expression for FKBP3 Gene

mRNA expression in normal human tissues for FKBP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FKBP3 Gene

This gene is overexpressed in Muscle - Skeletal (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FKBP3 Gene

SOURCE GeneReport for Unigene cluster for FKBP3 Gene Hs.509226

genes like me logo Genes that share expressions with FKBP3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FKBP3 Gene

Orthologs for FKBP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FKBP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FKBP3 35
  • 99.85 (n)
  • 100 (a)
FKBP3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FKBP3 35
  • 95.39 (n)
  • 97.77 (a)
FKBP3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 92 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
FKBP3 35
  • 95.39 (n)
  • 97.32 (a)
mouse
(Mus musculus)
Mammalia Fkbp3 35
  • 92.11 (n)
  • 94.2 (a)
Fkbp3 16
Fkbp3 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FKBP3 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FKBP3 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fkbp3 35
  • 91.22 (n)
  • 95.09 (a)
chicken
(Gallus gallus)
Aves FKBP25 36
  • 74 (a)
OneToOne
FKBP3 35
  • 72.05 (n)
  • 75.34 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 75 (a)
OneToMany
-- 36
  • 77 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.34809 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fkbp3 35
  • 74.14 (n)
  • 80.72 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
fkbp3 35
  • 67.88 (n)
  • 72.6 (a)
fkbp3 36
  • 58 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6826 36
  • 54 (a)
OneToOne
Species with no ortholog for FKBP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FKBP3 Gene

ENSEMBL:
Gene Tree for FKBP3 (if available)
TreeFam:
Gene Tree for FKBP3 (if available)

Paralogs for FKBP3 Gene

Paralogs for FKBP3 Gene

Pseudogenes.org Pseudogenes for FKBP3 Gene

genes like me logo Genes that share paralogs with FKBP3: view

Variants for FKBP3 Gene

Sequence variations from dbSNP and Humsavar for FKBP3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs748963 -- 45,131,264(+) GTTGA(C/G)ATTGC intron-variant
rs1272096 -- 45,131,465(-) tagta(A/G)agatg intron-variant
rs1543448 -- 45,126,848(-) ataga(A/G)ggaga intron-variant
rs2016737 -- 45,116,497(-) TATAT(A/G)TATAT intron-variant
rs2016738 -- 45,116,501(-) TCTCT(A/C)TATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FKBP3 Gene

Variant ID Type Subtype PubMed ID
nsv901841 CNV Loss 21882294
nsv901842 CNV Loss 21882294
nsv901843 CNV Gain 21882294
nsv832785 CNV Loss 17160897
esv2667757 CNV Deletion 23128226
esv2748676 CNV Deletion 23290073
nsv826941 CNV Loss 20364138

Relevant External Links for FKBP3 Gene

HapMap Linkage Disequilibrium report
FKBP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FKBP3 Gene

Disorders for FKBP3 Gene

Relevant External Links for FKBP3

Genetic Association Database (GAD)
FKBP3
Human Genome Epidemiology (HuGE) Navigator
FKBP3
genes like me logo Genes that share disorders with FKBP3: view

No data available for UniProtKB/Swiss-Prot for FKBP3 Gene

Publications for FKBP3 Gene

  1. cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein. (PMID: 1374240) Hung D.T. … Schreiber S.L. (Biochem. Biophys. Res. Commun. 1992) 2 3 4 23
  2. Molecular cloning of a 25-kDa high affinity rapamycin binding protein, FKBP25. (PMID: 1375932) Jin Y.-J. … Bierer B.E. (J. Biol. Chem. 1992) 3 4 23
  3. Isolation of a human cDNA encoding a 25 kDa FK-506 and rapamycin binding protein. (PMID: 1376117) Wiederrecht G. … Siekierka J.J. (Biochem. Biophys. Res. Commun. 1992) 3 4
  4. Interleukin-1 (IL-1) receptor blockade reduces endotoxin and Borrelia burgdorferi-stimulated IL-8 synthesis in human mononuclear cells. (PMID: 1532945) Porat R. … Dinarello C.A. (FASEB J. 1992) 2 3
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48

Products for FKBP3 Gene

  • Addgene plasmids for FKBP3

Sources for FKBP3 Gene

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