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FKBP3 Gene

protein-coding   GIFtS: 58
GCID: GC14M045584

FK506 Binding Protein 3, 25kDa

(Previous name: FK506-binding protein 3 (25kD))
  Search for FKBP3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FK506 Binding Protein 3, 25kDa1 2     PPIase FKBP32 3
FKBP252 3 5     PPIase2
FK506-Binding Protein 3 (25kD)1 2     FK506-Binding Protein 25, T-Cell2
Immunophilin FKBP252 3     Peptidyl-Prolyl Cis-Trans Isomerase FKBP32
Rapamycin-Selective 25 KDa Immunophilin2 3     Rapamycin Binding Protein2
25 KDa FK506-Binding Protein2 3     rotamase2
25 KDa FKBP2 3     EC 5.2.1.83
FKBP-252 3     Rotamase3
FKBP-32 3     FK506-Binding Protein 33

External Ids:    HGNC: 37191   Entrez Gene: 22872   Ensembl: ENSG000001004427   OMIM: 1869475   UniProtKB: Q006883   

Export aliases for FKBP3 gene to outside databases

Previous GC identifers: GC14M042906 GC14M039381 GC14M043574 GC14M043575 GC14M044654 GC14M025695


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FKBP3 Gene:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in
immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is
a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone
deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for
rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.
(provided by RefSeq, Sep 2008)

GeneCards Summary for FKBP3 Gene:
FKBP3 (FK506 binding protein 3, 25kDa) is a protein-coding gene. GO annotations related to this gene include FK506 binding and receptor activity. An important paralog of this gene is FKBP5.

UniProtKB/Swiss-Prot: FKBP3_HUMAN, Q00688
Function: FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two
immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission
pathways. PPIases accelerate the folding of proteins

Gene Wiki entry for FKBP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the FKBP3 gene promoter:
         USF1   AML1a   NCX/Ncx   MyoD   Pax-2   Lmo2   Pax-2a   FOXC1   USF-1   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FKBP3 promoter sequence
   Search Chromatin IP Primers for FKBP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FKBP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q21.2   Ensembl cytogenetic band:  14q21.2   HGNC cytogenetic band: 14q21.2

FKBP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FKBP3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M045584:  view genomic region     (about GC identifiers)

Start:
45,584,802 bp from pter      End:
45,604,522 bp from pter
Size:
19,721 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FKBP3_HUMAN, Q00688 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase FKBP3  
Size: 224 amino acids; 25177 Da
Sequence caution: Sequence=AAA58474.1; Type=Frameshift; Positions=197;
2 PDB 3D structures from and Proteopedia for FKBP3:
1PBK (3D)        2KFV (3D)    
Secondary accessions: B2R4Q9 Q14317

Explore the universe of human proteins at neXtProt for FKBP3: NX_Q00688

Explore proteomics data for FKBP3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys27
  • Modification sites at PhosphoSitePlus

  • See FKBP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002004.1  
    ENSEMBL proteins: 
     ENSP00000216330   ENSP00000452322   ENSP00000379374  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR023566 PPIase_FKBP
     IPR001179 PPIase_FKBP_dom

    Graphical View of Domain Structure for InterPro Entry Q00688

    ProtoNet protein and cluster: Q00688

    UniProtKB/Swiss-Prot: FKBP3_HUMAN, Q00688
    Similarity: Belongs to the FKBP-type PPIase family
    Similarity: Contains 1 PPIase FKBP-type domain


    Find genes that share domains with FKBP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FKBP3_HUMAN, Q00688
    Function: FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two
    immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission
    pathways. PPIases accelerate the folding of proteins
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)
    Enzyme regulation: Inhibited preferentially by rapamycin over FK506

         Genatlas biochemistry entry for FKBP3:
    FK506-binding protein 3,T cell binding protein FKBP-25 for the immunosuppressive agents FK506-rapamycin ,with
    intrinsic peptidyl-prolyl cis-trans isomerase activity

         Enzyme Number (IUBMB): EC 5.2.1.81

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity IBA--
    GO:0004872receptor activity TAS1374240
    GO:0005515protein binding IPI19166840
    GO:0005528FK506 binding IBA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with FKBP3           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FKBP3
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FKBP3

    miRNA
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    hsa-mir-155-5p (MIRT021002), hsa-mir-93-3p (MIRT038728), hsa-mir-98-5p (MIRT027824)

    Block miRNA regulation of human, mouse, rat FKBP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FKBP3 (see all 12):
    hsa-miR-21* hsa-miR-30c hsa-miR-589* hsa-miR-30d hsa-miR-4260 hsa-miR-373* hsa-miR-183* hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidFKBP3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FKBP3

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    Addgene plasmids for FKBP3 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBP3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FKBP3_HUMAN, Q00688: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    mitochondrion2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--
    GO:0016020membrane IBA--

    Find genes that share ontologies with FKBP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FKBP3 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling events mediated by HDAC Class I
    Signaling events mediated by HDAC Class I
    2Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway


    2 BioSystems Pathways for FKBP3
        Integrated Pancreatic Cancer Pathway
    Signaling events mediated by HDAC Class I



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FKBP3
    Interactions:

        GeneGlobe Interaction Network for FKBP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FKBP3 (Q006881, 2, 3 ENSP000002163304) via UniProtKB, MINT, STRING, and/or I2D (see all 109)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009871, 2, 3, ENSP000004172814EBI-1044081,EBI-389668 MINT-6823669 MINT-6823686 I2D: score=2 STRING: ENSP00000417281
    PARP2Q9UGN51, 2, 3, ENSP000002504164EBI-1044081,EBI-2795348 MINT-8201810 MINT-8202309 I2D: score=1 STRING: ENSP00000250416
    CSNK2BP678703, ENSP000003650254I2D: score=1 STRING: ENSP00000365025
    ENSG00000206406P678703I2D: score=1 
    ENSG00000224398P678703I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000413protein peptidyl-prolyl isomerization IBA--
    GO:0006457protein folding IEA--
    GO:0018208peptidyl-proline modification IBA--

    Find genes that share ontologies with FKBP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FKBP3

    2 Novoseek inferred chemical compound relationships for FKBP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tacrolimus 68.6 9 1375932 (4), 11744159 (1), 10557083 (1), 10361256 (1) (see all 5)
    rapamycin 61.3 8 1375932 (4), 10361256 (2), 8876379 (1)



    Find genes that share compounds with FKBP3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FKBP3 gene: 
    NM_002013.3  

    Unigene Cluster for FKBP3:

    FK506 binding protein 3, 25kDa
    Hs.509226  [show with all ESTs]
    Unigene Representative Sequence: BG112095
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216330(uc010tqf.2) ENST00000557324 ENST00000556231 ENST00000396062

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FKBP3 (see all 12):
    hsa-miR-21* hsa-miR-30c hsa-miR-589* hsa-miR-30d hsa-miR-4260 hsa-miR-373* hsa-miR-183* hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidFKBP3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FKBP3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FKBP3
    Addgene plasmids for FKBP3 
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      QuantiTect SYBR Green Assays in human, mouse, rat FKBP3
      QuantiFast Probe-based Assays in human, mouse, rat FKBP3

    Additional mRNA sequence: 

    AK222993.1 AK311915.1 BC016288.1 BC020809.1 BT006904.1 M96256.1 

    14 DOTS entries:

    DT.97848226  DT.100650820  DT.102832625  DT.75135406  DT.120745582  DT.95291372  DT.97861729  DT.100793859 
    DT.100808156  DT.95155156  DT.95291409  DT.95342135  DT.95344805  DT.121400187 

    Selected AceView cDNA sequences (see all 260):

    BC020809 CA773279 F32447 D57347 F36208 CR599673 BG747655 F35532 
    BQ576187 BG679365 BX377999 AI127948 BP371297 BU624292 BF515974 NM_002013 
    AA133184 AA610297 BI826498 CA309310 BE791551 BX356590 AA922160 BM756839 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FKBP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTAAACTT
    FKBP3 Expression
    About this image


    FKBP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Midbrain tegmentum
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    FKBP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FKBP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.509226
        Custom PCR Arrays for FKBP3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FKBP3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fkbp31 , 5 FK506 binding protein 31, 5 92.11(n)1
    94.2(a)1
      12 (27.21 cM)5
    307951  NM_013902.41  NP_038930.11 
     650624325 
    chicken
    (Gallus gallus)
    Aves FKBP31 FK506 binding protein 3, 25kDa 72.05(n)
    75.34(a)
      395353  NM_204641.1  NP_989972.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Peptidyl-prolyl cis-trans isomerase
    77(a)
    75(a)
    1 ↔ many
    1 ↔ many
    GL343274.1(101456-108097)
    1(212822801-212823429)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.348092 Xenopus laevis transcribed sequence with moderate similarity more 77.15(n)    BX855408.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570712212   -- 72.12(n)   368863  57071221 


    ENSEMBL Gene Tree for FKBP3 (if available)
    TreeFam Gene Tree for FKBP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FKBP3 gene
    FKBP52  FKBP1A2  FKBP1C2  FKBP42  FKBP82  FKBP62  FKBP1B2  
    Selected SIMAP similar genes for FKBP3 using alignment to 2 protein entries:     FKBP3_HUMAN (see all proteins) (see all similar genes):
    RTBDN    EML2    PLEKHH2    ZNF74    BTBD2    DNMT1
    FOPNL    DCTN5    EDRF1    ZNF737    OCEL1    LAMB4
    CATSPERG    ERBB2    FAM210A    IMPA1    NSRP1    UBIAD1

    Find genes that share paralogs with FKBP3           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for FKBP3
    PGOHUM00000243971 PGOHUM00000244492


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FKBP3 (see all 331)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1441302051,2
    C--45585426(+) CCACTT/GCAAAA 2 /E /A mis11Minor allele frequency- G:0.00NA 4538
    rs1138965161,2
    C--45585456(+) GAATTC/G/TTGTTG 1 -- spa11CSA 1
    rs762282531,2
    C,F--45585624(+) TTAATG/TAAGAC 1 -- int13Minor allele frequency- T:0.13WA CSA 122
    rs1381035311,2
    C--45585668(+) GGGGG-/G/GG  
            
    TGGAA
    1 -- int10--------
    rs1823576111,2
    --45585671(+) GCTGGA/GGGGGG 1 -- int10--------
    rs1875622901,2
    --45585692(+) AAAAAA/TATATA 1 -- int10--------
    rs1499543241,2
    --45585699(+) TATAT-/ACATATA 1 -- int10--------
    rs20167371,2
    C,A--45585700(-) TATATG/ATATAT 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs20167381,2
    C,F,A,H--45585704(-) TCTCTA/CTATGT 1 -- int114Minor allele frequency- C:0.08NS EA NA 1970
    rs1157782391,2
    F--45585706(+) ATATAG/TAGAGA 1 -- int11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for FKBP3 (45584802 - 45604522 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for FKBP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667757CNV Deletion23128226
    esv2748676CNV Deletion23290073
    nsv901842CNV Loss21882294
    nsv832785CNV Loss17160897
    nsv826941CNV Loss20364138
    nsv901841CNV Loss21882294
    nsv901843CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 186947    OMIM disorders: --


    Find genes that share disorders with FKBP3           About GenesLikeMe

    Genetic Association Database (GAD): FKBP3
    Human Genome Epidemiology (HuGE) Navigator: FKBP3 (3 documents)

    Export disorders for FKBP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FKBP3 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with FKBP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein. (PubMed id 1374240)1, 2, 3, 9 Hung D.T. and Schreiber S.L. (Biochem. Biophys. Res. Commun. 1992)
    2. Molecular cloning of a 25-kDa high affinity rapamycin binding protein, FKBP25. (PubMed id 1375932)1, 2, 9 Jin Y.-J.... Bierer B.E. (J. Biol. Chem. 1992)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Interleukin-1 (IL-1) receptor blockade reduces endotoxin and Borrelia burgdorferi-stimulated IL-8 synthesis in human mononuclear cells. (PubMed id 1532945)1, 3 Porat R....Dinarello C.A. (FASEB J. 1992)
    6. Isolation of a human cDNA encoding a 25 kDa FK-506 and rapamycin binding protein. (PubMed id 1376117)1, 2 Wiederrecht G.... Siekierka J.J. (Biochem. Biophys. Res. Commun. 1992)
    7. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    8. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. (PubMed id 23940030)1 Teixeira F.R....Gomes M.D. (J. Biol. Chem. 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2287 HGNC: 3719 AceView: FKBP3 Ensembl:ENSG00000100442 euGenes: HUgn2287
    ECgene: FKBP3 H-InvDB: FKBP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FKBP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FKBP3 gene:
    Search GeneIP for patents involving FKBP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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