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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FKBP3 Gene

protein-coding   GIFtS: 57
GCID: GC14M045584

FK506 Binding Protein 3, 25kDa

(Previous name: FK506-binding protein 3 (25kD))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
FK506 Binding Protein 3, 25kDa1 2     PPIase FKBP32 3
FK506-Binding Protein 3 (25kD)1 2     PPIase2
Immunophilin FKBP252 3     FK506-Binding Protein 25, T-Cell2
Rapamycin-Selective 25 KDa Immunophilin2 3     Peptidyl-Prolyl Cis-Trans Isomerase FKBP32
25 KDa FK506-Binding Protein2 3     Rapamycin Binding Protein2
25 KDa FKBP2 3     rotamase2
FKBP-252 3     EC 5.2.1.83
FKBP-32 3     Rotamase3
FKBP252 3     FK506-Binding Protein 33

External Ids:    HGNC: 37191   Entrez Gene: 22872   Ensembl: ENSG000001004427   OMIM: 1869475   UniProtKB: Q006883   

Export aliases for FKBP3 gene to outside databases

Previous GC identifers: GC14M042906 GC14M039381 GC14M043574 GC14M043575 GC14M044654 GC14M025695


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FKBP3 Gene:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in
immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is
a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone
deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for
rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.
(provided by RefSeq, Sep 2008)

GeneCards Summary for FKBP3 Gene: 
FKBP3 (FK506 binding protein 3, 25kDa) is a protein-coding gene. Diseases associated with FKBP3 include multiple myeloma, and myeloma. GO annotations related to this gene include FK506 binding and receptor activity. An important paralog of this gene is FKBP5.

UniProtKB/Swiss-Prot: FKBP3_HUMAN, Q00688
Function: FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two
immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission
pathways. PPIases accelerate the folding of proteins

Gene Wiki entry for FKBP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FKBP3 gene promoter:
         USF1   AML1a   NCX/Ncx   MyoD   Pax-2   Lmo2   Pax-2a   FOXC1   USF-1   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FKBP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for FKBP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FKBP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q21.2   Ensembl cytogenetic band:  14q21.2   HGNC cytogenetic band: 14q21.2

FKBP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FKBP3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M045584:  view genomic region     (about GC identifiers)

Start:
45,584,802 bp from pter      End:
45,604,522 bp from pter
Size:
19,721 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FKBP3_HUMAN, Q00688 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase FKBP3  
Size: 224 amino acids; 25177 Da
Subcellular location: Nucleus
Sequence caution: Sequence=AAA58474.1; Type=Frameshift; Positions=197;
2 PDB 3D structures from and Proteopedia for FKBP3:
1PBK (3D)        2KFV (3D)    
Secondary accessions: B2R4Q9 Q14317

Explore the universe of human proteins at neXtProt for FKBP3: NX_Q00688

Explore proteomics data for FKBP3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q00688

  • FKBP3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FKBP3 Protein Expression
    REFSEQ proteins: NP_002004.1  
    ENSEMBL proteins: 
     ENSP00000216330   ENSP00000452322   ENSP00000379374  

    Human Recombinant Protein Products for FKBP3: 
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    Novus Biologicals FKBP3 Proteins
    Novus Biologicals FKBP3 Lysates
    Sino Biological Recombinant Protein for FKBP3
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for FKBP3
    Cloud-Clone Corp. Proteins for FKBP3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--
    GO:0016020membrane IBA--

    FKBP3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR023566 PPIase_FKBP
     IPR001179 PPIase_FKBP_dom

    Graphical View of Domain Structure for InterPro Entry Q00688

    ProtoNet protein and cluster: Q00688

    UniProtKB/Swiss-Prot: FKBP3_HUMAN, Q00688
    Similarity: Belongs to the FKBP-type PPIase family
    Similarity: Contains 1 PPIase FKBP-type domain


    FKBP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FKBP3_HUMAN, Q00688
    Function: FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two
    immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission
    pathways. PPIases accelerate the folding of proteins
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)
    Enzyme regulation: Inhibited preferentially by rapamycin over FK506

         Genatlas biochemistry entry for FKBP3:
    FK506-binding protein 3,T cell binding protein FKBP-25 for the immunosuppressive agents FK506-rapamycin ,with
    intrinsic peptidyl-prolyl cis-trans isomerase activity

         Enzyme Number (IUBMB): EC 5.2.1.81

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity IBA--
    GO:0004872receptor activity TAS1374240
    GO:0005515protein binding IPI19166840
    GO:0005528FK506 binding IBA--
         
    FKBP3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FKBP3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FKBP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FKBP3 
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    SwitchGear 3'UTR luciferase reporter plasmidFKBP3 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBP3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FKBP3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling events mediated by HDAC Class I
    Signaling events mediated by HDAC Class I
    2Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway


    2 BioSystems Pathways for FKBP3
        Integrated Pancreatic Cancer Pathway
    Signaling events mediated by HDAC Class I



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FKBP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/30 Interacting proteins for FKBP3 (Q006882, 3 ENSP000002163304) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009872, 3, ENSP000004172814MINT-6823669 MINT-6823686 I2D: score=2 STRING: ENSP00000417281
    PARP2Q9UGN52, 3, ENSP000002504164MINT-8201810 MINT-8202309 I2D: score=1 STRING: ENSP00000250416
    CSNK2BP678703, ENSP000003650254I2D: score=1 STRING: ENSP00000365025
    ENSG00000206406P678703I2D: score=1 
    ENSG00000224398P678703I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000413protein peptidyl-prolyl isomerization IBA--
    GO:0006457protein folding IEA--
    GO:0018208peptidyl-proline modification IBA--

    FKBP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FKBP3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FKBP3

    2 Novoseek inferred chemical compound relationships for FKBP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tacrolimus 68.6 9 1375932 (4), 11744159 (1), 10557083 (1), 10361256 (1) (see all 5)
    rapamycin 61.3 8 1375932 (4), 10361256 (2), 8876379 (1)

    Search CenterWatch for drugs/clinical trials and news about FKBP3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FKBP3 gene: 
    NM_002013.3  

    Unigene Cluster for FKBP3:

    FK506 binding protein 3, 25kDa
    Hs.509226  [show with all ESTs]
    Unigene Representative Sequence: BG112095
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216330(uc010tqf.2) ENST00000557324 ENST00000556231 ENST00000396062

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    SwitchGear 3'UTR luciferase reporter plasmidFKBP3 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FKBP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FKBP3
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FKBP3

    Additional mRNA sequence: 

    AK222993.1 AK311915.1 BC016288.1 BC020809.1 BT006904.1 M96256.1 

    14 DOTS entries:

    DT.97848226  DT.100650820  DT.102832625  DT.75135406  DT.120745582  DT.95291372  DT.97861729  DT.100793859 
    DT.100808156  DT.95155156  DT.95291409  DT.95342135  DT.95344805  DT.121400187 

    24/260 AceView cDNA sequences (see all 260):

    BQ671642 AA301380 BC016288 CR623899 AA514235 F32447 CA849035 AW298537 
    CR590899 BI491246 AA661783 CA306672 CD677135 BI826083 BQ267778 BM712274 
    CB110992 AW572877 CR613618 BG573941 BF698903 BQ576187 CR599673 BM756839 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FKBP3 expression in normal human tissues (normalized intensities)      FKBP3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTAAACTT
    FKBP3 Expression
    About this image


    FKBP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/39 selected tissues (see all 39) fully expand
     
     Brain (Nervous System)    fully expand to see all 22 entries
             Thalamus
             Septum   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Lung (Respiratory System)    fully expand to see all 4 entries
             Stem Bronchi
             bronchus ; respiratory epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   

    See FKBP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FKBP3

    SOURCE GeneReport for Unigene cluster: Hs.509226
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FKBP3 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fkbp31 , 5 FK506 binding protein 31, 5 92.11(n)1
    94.2(a)1
      12 (27.21 cM)5
    307951  NM_013902.41  NP_038930.11 
     650624325 
    chicken
    (Gallus gallus)
    Aves FKBP31 FK506 binding protein 3, 25kDa 72.05(n)
    75.34(a)
      395353  NM_204641.1  NP_989972.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Peptidyl-prolyl cis-trans isomerase
    77(a)
    75(a)
    1 ↔ many
    1 ↔ many
    GL343274.1(101456-108097)
    1(212822801-212823429)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.348092 Xenopus laevis transcribed sequence with moderate similarity more 77.15(n)    BX855408.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570712212   -- 72.12(n)   368863  57071221 


    ENSEMBL Gene Tree for FKBP3 (if available)
    TreeFam Gene Tree for FKBP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FKBP3 gene
    FKBP52  FKBP1A2  FKBP1C2  FKBP42  FKBP82  FKBP62  FKBP1B2  
    18/75 SIMAP similar genes for FKBP3 using alignment to 2 protein entries:     FKBP3_HUMAN (see all proteins) (see all similar genes):
    RTBDN    EML2    PLEKHH2    ZNF74    BTBD2    DNMT1
    ARF3    FOPNL    C10orf137    DCTN5    ZNF737    OCEL1
    LAMB4    CATSPERG    ERBB2    FAM210A    IMPA1    NSRP1

    FKBP3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for FKBP3
    PGOHUM00000243971 PGOHUM00000244492


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/331 SNPs in FKBP3 are shown (see all 331)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1441302051,2
    C--45585426(+) CCACTT/GCAAAA 2 /E /A mis11Minor allele frequency- G:0.00NA 4538
    rs1138965161,2
    C--45585456(+) GAATTC/G/TTGTTG 1 -- spa11CSA 1
    rs762282531,2
    C,F--45585624(+) TTAATG/TAAGAC 1 -- int13Minor allele frequency- T:0.13WA CSA 122
    rs1381035311,2
    C--45585668(+) GGGGG-/G/GG  
            
    TGGAA
    1 -- int10--------
    rs1823576111,2
    --45585671(+) GCTGGA/GGGGGG 1 -- int10--------
    rs1875622901,2
    --45585692(+) AAAAAA/TATATA 1 -- int10--------
    rs1499543241,2
    --45585699(+) TATAT-/ACATATA 1 -- int10--------
    rs20167371,2
    C,A--45585700(-) TATATG/ATATAT 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs20167381,2
    C,F,A,H--45585704(-) TCTCTA/CTATGT 1 -- int114Minor allele frequency- C:0.08NS EA NA 1970
    rs1157782391,2
    F--45585706(+) ATATAG/TAGAGA 1 -- int11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for FKBP3 (45584802 - 45604522 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for FKBP3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2667757CNV Deletion23128226
    esv2748676CNV Deletion23290073
    nsv901842CNV Loss21882294
    nsv832785CNV Loss17160897
    nsv826941CNV Loss20364138
    nsv901841CNV Loss21882294
    nsv901843CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 186947    OMIM disorders: --

    5 diseases for FKBP3:    About MalaCards
    multiple myeloma    myeloma    pancreatic cancer    neuronitis
    pancreatitis


    FKBP3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FKBP3
    Human Genome Epidemiology (HuGE) Navigator: FKBP3 (3 documents)

    Export disorders for FKBP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FKBP3 gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with FKBP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein. (PubMed id 1374240)1, 2, 3, 9 Hung D.T. and Schreiber S.L. (1992)
    2. Molecular cloning of a 25-kDa high affinity rapamycin binding protein, FKBP25. (PubMed id 1375932)1, 2, 9 Jin Y.-J.... Bierer B.E. (1992)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Interleukin-1 (IL-1) receptor blockade reduces endotoxin and Borrelia burgdorferi-stimulated IL-8 synthesis in human mononuclear cells. (PubMed id 1532945)1, 3 Porat R....Dinarello C.A. (1992)
    6. Isolation of a human cDNA encoding a 25 kDa FK-506 and rapamycin binding protein. (PubMed id 1376117)1, 2 Wiederrecht G.... Siekierka J.J. (1992)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2287 HGNC: 3719 AceView: FKBP3 Ensembl:ENSG00000100442 euGenes: HUgn2287
    ECgene: FKBP3 H-InvDB: FKBP3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FKBP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FKBP3 gene:
    Search GeneIP for patents involving FKBP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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