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FKBP2 Gene

protein-coding   GIFtS: 62
GCID: GC11P064008

FK506 Binding Protein 2, 13kDa

(Previous name: FK506-binding protein 2 (13kD))
  Search for FKBP2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
FK506 Binding Protein 2, 13kDa1 2     FK506 Binding Protein 2 (13kD)1
FK506-Binding Protein 2 (13kD)1 2     Peptidyl-Prolyl Cis-Trans Isomerase1
Proline Isomerase1 2     PPIase2
Rapamycin-Binding Protein1 2     Peptidyl-Prolyl Cis-Trans Isomerase FKBP22
Immunophilin FKBP132 3     rotamase2
13 KDa FK506-Binding Protein2 3     EC 5.2.1.83
13 KDa FKBP2 3     FKBP133
FKBP-132 3     Rotamase3
FKBP-22 3     FK506-Binding Protein 23
PPIase FKBP22 3     

External Ids:    HGNC: 37181   Entrez Gene: 22862   Ensembl: ENSG000001734867   OMIM: 1869465   UniProtKB: P268853   
ORGUL members:         

Export aliases for FKBP2 gene to outside databases

Previous GC identifers: GC11P066524 GC11P065689 GC11P064259 GC11P063783 GC11P063764 GC11P060336


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FKBP2 Gene:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in
immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is
a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as
an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Multiple alternatively
spliced variants, encoding the same protein, have been identified. (provided by RefSeq, Sep 2008)

GeneCards Summary for FKBP2 Gene:
FKBP2 (FK506 binding protein 2, 13kDa) is a protein-coding gene. GO annotations related to this gene include FK506 binding and peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is FKBP11.

UniProtKB/Swiss-Prot: FKBP2_HUMAN, P26885
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
peptide bonds in oligopeptides

Gene Wiki entry for FKBP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FKBP2 gene promoter:
         E2F-1   E2F   E2F-2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFKBP2 promoter sequence
   Search Chromatin IP Primers for FKBP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FKBP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1-q13.3   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1-q13.3

FKBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FKBP2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P064008:  view genomic region     (about GC identifiers)

Start:
64,008,413 bp from pter      End:
64,011,607 bp from pter
Size:
3,195 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FKBP2_HUMAN, P26885 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase FKBP2 precursor  
Size: 142 amino acids; 15649 Da
Subunit: Interacts with ARFGEF1/BIG1 and the C-terminal of EPB41L2
1 PDB 3D structure from and Proteopedia for FKBP2:
2PBC (3D)    
Secondary accessions: Q5BJH9 Q9BTS7

Explore the universe of human proteins at neXtProt for FKBP2: NX_P26885

Explore proteomics data for FKBP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FKBP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001128680.1  NP_004461.2  NP_476433.1  

    ENSEMBL proteins: 
     ENSP00000310935   ENSP00000398147   ENSP00000438749   ENSP00000378046  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR023566 PPIase_FKBP
     IPR001179 PPIase_FKBP_dom

    Graphical View of Domain Structure for InterPro Entry P26885

    ProtoNet protein and cluster: P26885

    UniProtKB/Swiss-Prot: FKBP2_HUMAN, P26885
    Similarity: Belongs to the FKBP-type PPIase family. FKBP2 subfamily
    Similarity: Contains 1 PPIase FKBP-type domain


    Find genes that share domains with FKBP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FKBP2_HUMAN, P26885
    Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic
    peptide bonds in oligopeptides
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)
    Enzyme regulation: Inhibited by both FK506 and rapamycin

         Genatlas biochemistry entry for FKBP2:
    FK506-binding protein 2,T cell binding protein FKBP-13 for the immunosuppressive agents FK506-rapamycin,with
    intrinsic peptidyl-prolyl cis-trans isomerase activity

         Enzyme Number (IUBMB): EC 5.2.1.81

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity IBA--
    GO:0005515protein binding IPI16713569
    GO:0005528FK506 binding IBA--
         
    Find genes that share ontologies with FKBP2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FKBP2:
     Increased HPV18 LCR reporter a 

    Animal Models:
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    miRTarBase miRNAs that target FKBP2:
    hsa-mir-26b-5p (MIRT028754)

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    hsa-miR-670 hsa-miR-129-5p hsa-miR-622 hsa-miR-212 hsa-miR-132
    SwitchGear 3'UTR luciferase reporter plasmidFKBP2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FKBP2_HUMAN, P26885: Endoplasmic reticulum membrane; Peripheral membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    chloroplast2
    extracellular2
    nucleus2
    cytosol1
    golgi apparatus1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS1713687
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016020membrane IBA--

    Find genes that share ontologies with FKBP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FKBP2
    Interactions:

        Search GeneGlobe Interaction Network for FKBP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FKBP2 (P268851, 2, 3 ENSP000003109354) via UniProtKB, MINT, STRING, and/or I2D (see all 139)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000413protein peptidyl-prolyl isomerization IBA--
    GO:0006457protein folding IEA--
    GO:0018208peptidyl-proline modification IBA--

    Find genes that share ontologies with FKBP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FKBP2

    3 Novoseek inferred chemical compound relationships for FKBP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tacrolimus 72.7 12 1713687 (2), 7505249 (2), 7642551 (2), 12606707 (2) (see all 6)
    proline 72 17 1730298 (3), 19956261 (2), 10228556 (1), 16179256 (1) (see all 11)
    rapamycin 70.1 7 7642551 (2), 1713687 (1), 7505249 (1), 16179256 (1)



    Find genes that share compounds with FKBP2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FKBP2 gene (3 alternative transcripts): 
    NM_001135208.1  NM_004470.3  NM_057092.2  

    Unigene Cluster for FKBP2:

    FK506 binding protein 2, 13kDa
    Hs.227729  [show with all ESTs]
    Unigene Representative Sequence: BM908616
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000536642 ENST00000309366(uc001nyy.3) ENST00000541388 ENST00000449942(uc010rnh.2)
    ENST00000535135 ENST00000394540(uc001nyz.3)
    miRNA
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    hsa-miR-670 hsa-miR-129-5p hsa-miR-622 hsa-miR-212 hsa-miR-132
    SwitchGear 3'UTR luciferase reporter plasmidFKBP2 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat FKBP2
      QuantiFast Probe-based Assays in human, mouse, rat FKBP2

    Additional mRNA sequence: 

    BC003384.1 BC091475.1 BT009861.1 CR407636.1 M65128.1 M75099.1 

    12 DOTS entries:

    DT.447904  DT.75100473  DT.120749833  DT.100791321  DT.97844717  DT.101983608  DT.95167967  DT.97844719 
    DT.100026783  DT.100791323  DT.102824415  DT.91731972 

    Selected AceView cDNA sequences (see all 191):

    BQ776603 AI927206 BE018846 BQ776919 AI640183 BM693847 BM699932 BE466709 
    AW593730 BM699422 AI492645 BM798823 AI825756 BF436905 AA579634 BG756897 
    AI420331 AI823750 BM670069 CR407636 AI867505 BQ301812 AI865533 BG170997 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FKBP2 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8
    SP1:              -     -     -                       -         
    SP2:                    -     -                       -         
    SP3:                                                  -         
    SP4:              -     -     -                                 
    SP5:              -     -     -                                 


    ECgene alternative splicing isoforms for FKBP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FKBP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACTACACGG
    FKBP2 Expression
    About this image


    FKBP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebellum
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    FKBP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FKBP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.227729

    UniProtKB/Swiss-Prot: FKBP2_HUMAN, P26885
    Tissue specificity: T-cells and thymus

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FKBP2 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fkbp21 , 5 FK506 binding protein 21, 5 88.57(n)1
    96.43(a)1
      19 (5.12 cM)5
    142271  NM_001166368.11  NP_001159840.11 
     69777415 
    lizard
    (Anolis carolinensis)
    Reptilia FKBP26
    FK506 binding protein 2, 13kDa
    80(a)
    1 ↔ 1
    GL343555.1(469855-475052)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480116882   -- 76.88(n)    48011688 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.95572 Transcribed sequence with moderate similarity to protein more 76.53(n)    BI326378.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG147151 , 3 FK506 binding3
    CG147151
    53(a)3
    63.13(n)1
    58.33(a)1
      86E183
    414031  NM_141844.41  NP_650101.11 
    worm
    (Caenorhabditis elegans)
    Secernentea fkb-11 , 3 FK506-binding protein3
    fkb-11
    65(a)3
    59.37(n)1
    65.62(a)1
      IV(11036504-11037444)3
    1916341  NM_001268602.11  NP_001255531.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FPR2(YDR519W)4
    FPR21
    Membrane-bound peptidyl-prolyl cis-trans isomerase more4
    FPR21
    51.4(n)1
    59.81(a)1
      4(1480425-1480832)4
    8521311, 4  NP_010807.31  NP_010807.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons FKBP15-11 FKBP15-1 55.64(n)
    57.48(a)
      822115  NM_113428.3  NP_566762.1 
    rice
    (Oryza sativa)
    Liliopsida Os.76392 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 71.43(n)    AK103859.1 


    ENSEMBL Gene Tree for FKBP2 (if available)
    TreeFam Gene Tree for FKBP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FKBP2 gene
    FKBP112  FKBP142  FKBP102  FKBP92  FKBP72  
    13 SIMAP similar genes for FKBP2 using alignment to 3 protein entries:     FKBP2_HUMAN (see all proteins):
    FKBP9    FKBP1C    FKBP4    FKBP10    FKBP1B    FKBP1A
    FKBP12-Exip2    FKBP14    FKBP7    DKFZp666D193    FKBP5    FKBP3
    FKBP11

    Find genes that share paralogs with FKBP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FKBP2 (see all 95)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1415927441,2
    --63926884(+) GAAAGC/GGGTTA 1 -- us2k10--------
    rs1453518961,2
    --63926908(+) ACCGCC/TTCCAG 1 -- us2k10--------
    rs23612171,2
    C,F--63926943(-) AAGCAT/CTGTGC 1 -- us2k1 tfbs31Minor allele frequency- C:0.02NA 120
    rs1176371021,2
    C,F--63926955(+) ACATGC/TACCTC 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs6116371,2
    C,F,H--63926968(-) AGGAGG/AAAGTG 1 -- us2k1 trp323Minor allele frequency- A:0.07NA NS EA WA CSA 1589
    rs754455151,2
    --63927082(+) TCTCCC/GTAACC 1 -- us2k10--------
    rs591409281,2
    --63927163(+) GGGGCG/TCCTGA 1 -- us2k10--------
    rs116070071,2
    C,F,H--63927213(+) CCAGTC/TATGAG 1 -- us2k1 tfbs327Minor allele frequency- T:0.15NS EA NA CSA WA 2858
    rs617612841,2
    C,F--63927281(+) AGGAGC/GATTGG 1 -- us2k13Minor allele frequency- G:0.02NS EA 212
    rs1870157311,2
    --63927456(+) CACAGC/TGACTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FKBP2 (64008413 - 64011607 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for FKBP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744614CNV Deletion23290073
    dgv1165n71CNV Loss21882294
    dgv1166n71CNV Loss21882294
    dgv1156n71CNV Loss21882294
    dgv1167n71CNV Loss21882294
    dgv1164n71CNV Loss21882294
    nsv832186CNV Loss17160897
    dgv1163n71CNV Loss21882294
    nsv469961CNV Loss18288195
    esv24861CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 186946    OMIM disorders: --


    Find genes that share disorders with FKBP2           About GenesLikeMe

    Genetic Association Database (GAD): FKBP2
    Human Genome Epidemiology (HuGE) Navigator: FKBP2 (3 documents)

    Export disorders for FKBP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FKBP2 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with FKBP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13. (PubMed id 1713687)1, 2, 3, 9 Jin Y.-J....Burakoff S.J. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    2. Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506. (PubMed id 12606707)1, 2, 9 Padilla P.I....Vaughan M. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    3. Chromosomal band assignments of the genes encoding human FKBP12 and FKBP13. (PubMed id 1281998)1, 2, 9 Dilella A.G.... Griffin C.A. (Biochem. Biophys. Res. Commun. 1992)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Induction of the FK506-binding protein, FKBP13, under conditions which misfold proteins in the endoplasmic reticulum. (PubMed id 7526846)1, 9 Bush K.T....Nigam S.K. (Biochem. J. 1994)
    7. Structural organization of the genes encoding human and murine FK506-binding protein (FKBP) 13 and comparison to FKBP1. (PubMed id 7505249)1, 9 Hendrickson B.A....DiLella A.G. (Gene 1993)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2286 HGNC: 3718 AceView: FKBP2 Ensembl:ENSG00000173486 euGenes: HUgn2286
    ECgene: FKBP2 H-InvDB: FKBP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FKBP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FKBP2 gene:
    Search GeneIP for patents involving FKBP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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