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Aliases for FKBP2 Gene

Aliases for FKBP2 Gene

  • FK506 Binding Protein 2, 13kDa 2 3
  • FK506-Binding Protein 2 (13kD) 2 3
  • 13 KDa FK506-Binding Protein 3 4
  • Rapamycin-Binding Protein 2 3
  • Immunophilin FKBP13 3 4
  • Proline Isomerase 2 3
  • PPIase FKBP2 3 4
  • 13 KDa FKBP 3 4
  • Rotamase 3 4
  • FKBP-13 3 4
  • FKBP-2 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase 2
  • FK506 Binding Protein 2 (13kD) 2
  • FK506-Binding Protein 2 4
  • EC 5.2.1.8 4
  • PPIASE 3
  • FKBP13 4

External Ids for FKBP2 Gene

Previous GeneCards Identifiers for FKBP2 Gene

  • GC11P066524
  • GC11P065689
  • GC11P064259
  • GC11P063783
  • GC11P063764
  • GC11P064008
  • GC11P060336

Summaries for FKBP2 Gene

Entrez Gene Summary for FKBP2 Gene

  • The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]

GeneCards Summary for FKBP2 Gene

FKBP2 (FK506 Binding Protein 2, 13kDa) is a Protein Coding gene. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and FK506 binding. An important paralog of this gene is FKBP7.

UniProtKB/Swiss-Prot for FKBP2 Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides

Gene Wiki entry for FKBP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBP2 Gene

Genomics for FKBP2 Gene

Regulatory Elements for FKBP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FKBP2 Gene

Chromosome:
11
Start:
64,240,941 bp from pter
End:
64,244,135 bp from pter
Size:
3,195 bases
Orientation:
Plus strand

Genomic View for FKBP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FKBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP2 Gene

Proteins for FKBP2 Gene

  • Protein details for FKBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26885-FKBP2_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP2
    Protein Accession:
    P26885
    Secondary Accessions:
    • Q5BJH9
    • Q9BTS7

    Protein attributes for FKBP2 Gene

    Size:
    142 amino acids
    Molecular mass:
    15649 Da
    Quaternary structure:
    • Interacts with ARFGEF1/BIG1 and the C-terminal of EPB41L2.

    Three dimensional structures from OCA and Proteopedia for FKBP2 Gene

neXtProt entry for FKBP2 Gene

Proteomics data for FKBP2 Gene at MOPED

Post-translational modifications for FKBP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FKBP2 Gene

Antibody Products

No data available for DME Specific Peptides for FKBP2 Gene

Domains & Families for FKBP2 Gene

Gene Families for FKBP2 Gene

Protein Domains for FKBP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FKBP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P26885

UniProtKB/Swiss-Prot:

FKBP2_HUMAN :
  • Contains 1 PPIase FKBP-type domain.
  • Belongs to the FKBP-type PPIase family. FKBP2 subfamily.
Domain:
  • Contains 1 PPIase FKBP-type domain.
Family:
  • Belongs to the FKBP-type PPIase family. FKBP2 subfamily.
genes like me logo Genes that share domains with FKBP2: view

Function for FKBP2 Gene

Molecular function for FKBP2 Gene

GENATLAS Biochemistry:
FK506-binding protein 2,T cell binding protein FKBP-13 for the immunosuppressive agents FK506-rapamycin,with intrinsic peptidyl-prolyl cis-trans isomerase activity
UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0)
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by both FK506 and rapamycin
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides

Enzyme Numbers (IUBMB) for FKBP2 Gene

Gene Ontology (GO) - Molecular Function for FKBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0005515 protein binding IPI 16713569
GO:0005528 FK506 binding TAS 1713687
genes like me logo Genes that share ontologies with FKBP2: view
genes like me logo Genes that share phenotypes with FKBP2: view

Animal Model Products

miRNA for FKBP2 Gene

miRTarBase miRNAs that target FKBP2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FKBP2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for FKBP2 Gene

Localization for FKBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP2 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FKBP2 Gene COMPARTMENTS Subcellular localization image for FKBP2 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
chloroplast 2
plasma membrane 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FKBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005783 endoplasmic reticulum TAS 1713687
GO:0005789 endoplasmic reticulum membrane IBA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FKBP2: view

Pathways & Interactions for FKBP2 Gene

SuperPathways for FKBP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FKBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IBA --
GO:0006457 protein folding --
GO:0061077 chaperone-mediated protein folding IBA --
genes like me logo Genes that share ontologies with FKBP2: view

No data available for Pathways by source and SIGNOR curated interactions for FKBP2 Gene

Drugs & Compounds for FKBP2 Gene

(3) Drugs for FKBP2 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tacrolimus Approved, Investigational Pharma 992
Rapamycin Pharma mTOR inhibitor 0
proline Nutra 20
genes like me logo Genes that share compounds with FKBP2: view

Transcripts for FKBP2 Gene

Unigene Clusters for FKBP2 Gene

FK506 binding protein 2, 13kDa:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FKBP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8
SP1: - - - -
SP2: - - -
SP3: -
SP4: - - -
SP5: - - -
SP6: -

Relevant External Links for FKBP2 Gene

GeneLoc Exon Structure for
FKBP2
ECgene alternative splicing isoforms for
FKBP2

Expression for FKBP2 Gene

mRNA expression in normal human tissues for FKBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FKBP2 Gene

This gene is overexpressed in Oral epithelium (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FKBP2 Gene



SOURCE GeneReport for Unigene cluster for FKBP2 Gene Hs.227729

mRNA Expression by UniProt/SwissProt for FKBP2 Gene

P26885-FKBP2_HUMAN
Tissue specificity: T-cells and thymus
genes like me logo Genes that share expression patterns with FKBP2: view

Protein tissue co-expression partners for FKBP2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for FKBP2 Gene

Orthologs for FKBP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FKBP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FKBP2 35
  • 92.86 (n)
  • 97.14 (a)
-- 36
  • 86 (a)
OneToMany
FKBP2 36
  • 84 (a)
OneToMany
dog
(Canis familiaris)
Mammalia FKBP2 35
  • 93.57 (n)
  • 97.86 (a)
FKBP2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fkbp2 35
  • 88.57 (n)
  • 96.43 (a)
Fkbp2 16
Fkbp2 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FKBP2 35
  • 99.53 (n)
  • 99.3 (a)
FKBP2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fkbp2 35
  • 87.62 (n)
  • 97.14 (a)
lizard
(Anolis carolinensis)
Reptilia FKBP2 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fkbp2 35
  • 71.06 (n)
  • 78.29 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.9557 35
fkbp2 35
  • 72.49 (n)
  • 79.37 (a)
fkbp2 36
  • 81 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10889 35
fruit fly
(Drosophila melanogaster)
Insecta CG14715 37
  • 53 (a)
CG14715 35
  • 63.13 (n)
  • 58.33 (a)
CG14715 36
  • 52 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003134 35
  • 69.25 (n)
  • 68.22 (a)
worm
(Caenorhabditis elegans)
Secernentea fkb-1 37
  • 65 (a)
fkb-1 35
  • 59.37 (n)
  • 65.62 (a)
fkb-1 36
  • 61 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C01045g 35
  • 47.7 (n)
  • 56.9 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPR2 35
  • 51.4 (n)
  • 59.81 (a)
FPR2 36
  • 50 (a)
OneToMany
FPR2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons FKBP15-1 35
  • 55.64 (n)
  • 57.48 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7005 35
barley
(Hordeum vulgare)
Liliopsida Hv.929 35
rice
(Oryza sativa)
Liliopsida Os.7639 35
Os09g0501850 35
  • 56.92 (n)
  • 55.38 (a)
corn
(Zea mays)
Liliopsida Zm.6224 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02455 35
  • 53 (n)
  • 49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
OneToMany
Species with no ortholog for FKBP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FKBP2 Gene

ENSEMBL:
Gene Tree for FKBP2 (if available)
TreeFam:
Gene Tree for FKBP2 (if available)

Paralogs for FKBP2 Gene

Paralogs for FKBP2 Gene

(13) SIMAP similar genes for FKBP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FKBP2: view

Variants for FKBP2 Gene

Sequence variations from dbSNP and Humsavar for FKBP2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs4672 - 64,242,407(+) GTTCC(A/G)GGTCC missense, reference
rs611637 -- 64,240,259(-) AGGAG(A/G)AAGTG upstream-variant-2KB
rs2070765 -- 64,242,613(+) CAGAG(A/G)GTGCT intron-variant
rs2307717 -- 64,239,784(-) GATGA(-/TGA)AGGAA upstream-variant-2KB
rs2361217 -- 64,240,234(-) AAGCA(C/T)TGTGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FKBP2 Gene

Variant ID Type Subtype PubMed ID
dgv1156n71 CNV Loss 21882294
nsv469961 CNV Loss 18288195
dgv1163n71 CNV Loss 21882294
dgv1164n71 CNV Loss 21882294
dgv1165n71 CNV Loss 21882294
dgv1166n71 CNV Loss 21882294
nsv832186 CNV Loss 17160897
dgv1167n71 CNV Loss 21882294
esv24861 CNV Gain 19812545
esv2744614 CNV Deletion 23290073

Variation tolerance for FKBP2 Gene

Residual Variation Intolerance Score: 58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.08; 50.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FKBP2 Gene

HapMap Linkage Disequilibrium report
FKBP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FKBP2 Gene

Disorders for FKBP2 Gene

Relevant External Links for FKBP2

Genetic Association Database (GAD)
FKBP2
Human Genome Epidemiology (HuGE) Navigator
FKBP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FKBP2
genes like me logo Genes that share disorders with FKBP2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FKBP2 Gene

Publications for FKBP2 Gene

  1. Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13. (PMID: 1713687) Jin Y.-J. … Burakoff S.J. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 23 67
  2. Peptidyl-prolyl isomerase FKBP52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening. (PMID: 19945390) Shim S. … Worley P.F. (Neuron 2009) 23 67
  3. Hidden alternative structures of proline isomerase essential for catalysis. (PMID: 19956261) Fraser J.S. … Alber T. (Nature 2009) 23 67
  4. Redox regulation in the chloroplast thylakoid lumen: a new frontier in photosynthesis research. (PMID: 15851415) Buchanan B.B. … Luan S. (J. Exp. Bot. 2005) 23 67
  5. Pin1: a proline isomerase that makes you wheeze? (PMID: 16369562) Anderson P. (Nat. Immunol. 2005) 23 67

Products for FKBP2 Gene

Sources for FKBP2 Gene

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