FKBP1C Gene
protein-coding GIFtS: 22
GCID: GC06P063921
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FK506 binding protein 1C
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Aliases
for FKBP1C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| FK506 Binding Protein 1C1 2 | | BA184C23.21 |
Export aliases for FKBP1C gene to outside databasesPrevious GC identifers: GC06P063918 GC06P063979 GC06P061101 |
Summaries
for FKBP1C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FKBP1C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for FKBP1C
Other transcription factors
Search SABiosciences Chromatin IP Primers for FKBP1C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FKBP1C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q12 Ensembl cytogenetic band: 6q12 HGNC cytogenetic band: 6q12FKBP1C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P063921: view genomic region
(about GC identifiers)
Start:
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63,921,351 bp from pter |
End:
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63,922,932 bp from pter |
Size:
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1,582 bases |
Orientation:
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plus strand |
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Proteins
for FKBP1C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/TrEMBL: A8MSS1 (See
protein sequence)Recommended Name: Peptidyl-prolyl cis-trans isomerase Size: 92 amino acids; 10156 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered aspreliminary dataUniProtKB/TrEMBL: Q5VVH2 (See
protein sequence) Recommended Name: Peptidyl-prolyl cis-trans isomerase Size: 108 amino acids; 12179 DaPost-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5VVH2
FKBP1C Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000359693 ENSP00000348493
Human Recombinant Protein Products:
FKBP1C Antibody Products:
Assay Products for FKBP1C: |
Protein
Domains /
Families
for FKBP1C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FKBP1C for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A8MSS1Graphical View of Domain Structure for InterPro Entry Q5VVH2ProtoNet protein and cluster: A8MSS1 UniProtKB/TrEMBL: A8MSS1 Similarity: Contains 1 PPIase FKBP-type domainUniProtKB/TrEMBL: Q5VVH2 Similarity: Contains 1 PPIase FKBP-type domain |
Function
for FKBP1C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003755 | peptidyl-prolyl cis-trans isomerase activity |
-- | -- |
FKBP1C for ontologies About GeneDecksing
|
Pathways & Interactions
for FKBP1C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FKBP1C
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5 Interacting proteins for FKBP1C (ENSP000003596934) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006457 | protein folding |
-- | -- |
FKBP1C for ontologies About GeneDecksing
|
Drugs & Compounds
for FKBP1C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Compounds for FKBP1C available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| Ascomycin | Calcineurin phosphatase inhibitor; analog of FK 506 (Cat. No. 3631) | [104987-12-4] |
Search CenterWatch for drugs/clinical trials and news about FKBP1C 
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Transcripts
for FKBP1C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000370659 ENST00000356170
GeneLoc Exon Structure
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Expression
for FKBP1C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FKBP1C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See FKBP1C Protein Expression from SPIRE MOPED and PaxDB SABiosciences Custom PCR Arrays for FKBP1C
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FKBP1C | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FKBP1C | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FKBP1C |
Orthologs
for FKBP1C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for FKBP1C gene from 7/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
88(a) |
1 → many |
GL343346.1(874569-875912) |
zebrafish
(Danio rerio) |
Actinopterygii |
fkbp1ab6fkbp1aa6 |
FK506 binding protein 1Aa |
80(a)76(a) |
possible orthologpossible ortholog |
23(16859138-16863030) 8(51430612-51433344) |
fruit fly
(Drosophila melanogaster) |
Insecta |
FK506-bp26 |
FK506-binding protein 2 |
71(a) |
1 → many |
2R(15177607-15178467) |
worm
(Caenorhabditis elegans) |
Secernentea |
fkb-26fkb-86 |
FK506-Binding protein family member (fkb-8) |
57(a)16(a) |
possible orthologpossible ortholog |
I(12918709-12919282) I(12916431-12918098) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT3G555206 |
FKBP-like peptidyl-prolyl cis-trans isomerase fami... |
21(a) |
possible ortholog |
3(20593661-20595345) |
rice
(Oryza sativa) |
Liliopsida |
---- |
peptidyl-prolyl cis-trans isomerase, FKBP-type, pu...peptidyl-prolyl cis-trans isomerase, FKBP-type, pu... |
22(a)20(a) |
possible orthologpossible ortholog |
1(36252504-36255934) 5(22429840-22432453) |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
fklB6fkpA6 |
FKBP-type peptidyl-prolyl cis-trans isomerase (rot...FKBP-type peptidyl-prolyl cis-trans isomerase (rot... |
21(a)17(a) |
possible orthologpossible ortholog |
Chromosome(4426958-4427578) Chromosome(3474629-3475441) |
ENSEMBL Gene Tree for FKBP1C (if available)
TreeFam Gene Tree for FKBP1C (if available) |
Paralogs
for FKBP1C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FKBP1C gene
- FKBP52 FKBP1A2 FKBP42 FKBP82 FKBP62 FKBP1B2 FKBP32
17 SIMAP similar genes for FKBP1C using alignment to 2 protein entries: A8MSS1_HUMAN (see all proteins):FKBP12-Exin FKBP12-Exip3 FKBP1A FKBP12-Exip2 FKBP1B FKBP4
FKBP6 FKBP2 FKBP3 FKBP5 FKBP14 FKBP9
FKBP10 DKFZp666D193 FKBP7 FKBP11 FKBP8
FKBP1C for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for FKBP1C
PGOHUM00000238526
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Genomic Variants
for FKBP1C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for FKBP1C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FKBP1C for disorders About GeneDecksing
1  disease for FKBP1C: About MalaCardsfibrodysplasia ossificans progressiva
Export disorders for FKBP1C gene to outside databases
|
Publications
for FKBP1C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
| -- |
External Searches for FKBP1C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing FKBP1C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing FKBP1C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FKBP1C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FKBP1C | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FKBP1C gene:
Search GeneIP for patents involving FKBP1C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FKBP1C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FKBP1C | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FKBP1C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FKBP1C | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FKBP1C | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FKBP1C | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FKBP1C |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for FKBP1C |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FKBP1C |
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