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FKBP1C Gene

protein-coding   GIFtS: 21
GCID: GC06P063921

FK506 Binding Protein 1C

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FK506 Binding Protein 1C1 2
bA184C23.22

External Ids:    HGNC: 213761   Entrez Gene: 6424892   Ensembl: ENSG000001982257   UniProtKB: A8MSS14   UniProtKB: Q5VVH24   

Export aliases for FKBP1C gene to outside databases

Previous GC identifers: GC06P063918 GC06P063979 GC06P061101


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FKBP1C Gene:
FKBP1C (FK506 binding protein 1C) is a protein-coding gene. An important paralog of this gene is FKBP5.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for FKBP1C
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FKBP1C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FKBP1C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q12   Ensembl cytogenetic band:  6q12   HGNC cytogenetic band: 6q12

FKBP1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FKBP1C gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P063921:  view genomic region     (about GC identifiers)

Start:
63,921,351 bp from pter      End:
63,922,929 bp from pter
Size:
1,579 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/TrEMBL: A8MSS1 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase  
Size: 92 amino acids; 10156 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: Q5VVH2 (See protein sequence)

Recommended Name: Peptidyl-prolyl cis-trans isomerase  
Size: 108 amino acids; 12179 Da

Explore proteomics data for FKBP1C at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FKBP1C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


    ENSEMBL proteins: 
     ENSP00000359693   ENSP00000348493  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR023566 PPIase_FKBP
     IPR001179 PPIase_FKBP_dom

    Graphical View of Domain Structure for InterPro Entry A8MSS1
    Graphical View of Domain Structure for InterPro Entry Q5VVH2

    ProtoNet protein and cluster: A8MSS1

    UniProtKB/TrEMBL: A8MSS1
    Similarity: Contains 1 PPIase FKBP-type domain

    UniProtKB/TrEMBL: Q5VVH2
    Similarity: Contains 1 PPIase FKBP-type domain


    Find genes that share domains with FKBP1C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity ----
         
    Find genes that share ontologies with FKBP1C           About GenesLikeMe


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    extracellular1
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FKBP1C
    Interactions:

        Search GeneGlobe Interaction Network for FKBP1C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FKBP1C (ENSP000003596934) via UniProtKB, MINT, STRING, and/or I2D (see all 100)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GTF2H1ENSP000002659634STRING: ENSP00000265963
    ATP6V0CENSP000003297574STRING: ENSP00000329757
    PIN1ENSP000002479704STRING: ENSP00000247970
    PPP3R1ENSP000002343104STRING: ENSP00000234310
    PPP3R2ENSP000003639394STRING: ENSP00000363939
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding ----

    Find genes that share ontologies with FKBP1C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for FKBP1C



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370659 ENST00000356170
    miRNA
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FKBP1C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FKBP1C Expression
    About this image

    FKBP1C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FKBP1C Protein Expression
        Custom PCR Arrays for FKBP1C
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FKBP1C gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves FKBP126
    peptidyl-prolyl cis-trans isomerase FKBP1A
    90(a)
    1 → many
    20(10173343-10175225)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Peptidyl-prolyl cis-trans isomerase
    88(a)
    1 → many
    GL343346.1(874566-875912)
    zebrafish
    (Danio rerio)
    Actinopterygii fkbp1aa6
    FK506 binding protein 1Aa
    76(a)
    many ↔ many
    8(51430612-51433344) ENSDARG00000022684
    fruit fly
    (Drosophila melanogaster)
    Insecta FK506-bp26
    FK506-binding protein 2
    71(a)
    1 → many
    2R(15177607-15178467)
    worm
    (Caenorhabditis elegans)
    Secernentea fkb-86
    Protein FKB-8 (fkb-8) mRNA, complete cds
    16(a)
    many ↔ many
    I(12916441-12918109) WBGene00001433
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FPR16
    Peptidyl-prolyl cis-trans isomerase (PPIase), bind...
    53(a)
    1 → many
    XIV(371882-372226) YNL135C
            Species with no ortholog for FKBP1C

    ENSEMBL Gene Tree for FKBP1C (if available)
    TreeFam Gene Tree for FKBP1C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FKBP1C gene
    FKBP52  FKBP1A2  FKBP42  FKBP82  FKBP62  FKBP1B2  FKBP32  
    17 SIMAP similar genes for FKBP1C using alignment to 2 protein entries:     A8MSS1_HUMAN (see all proteins):
    FKBP12-Exin    FKBP12-Exip3    FKBP1A    FKBP12-Exip2    FKBP1B    FKBP4
    FKBP6    FKBP2    FKBP3    FKBP5    FKBP14    FKBP9
    FKBP10    DKFZp666D193    FKBP7    FKBP11    FKBP8

    Find genes that share paralogs with FKBP1C           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for FKBP1C
    PGOHUM00000238526


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing FKBP1C
    DNA2.0 Custom Variant and Variant Library Synthesis for FKBP1C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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      --

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 642489 HGNC: 21376 Ensembl:ENSG00000198225 euGenes: HUgn642489 ECgene: FKBP1C
    H-InvDB: FKBP1C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FKBP1C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FKBP1C gene:
    Search GeneIP for patents involving FKBP1C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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