Aliases for FKBP1B Gene
External Ids for FKBP1B Gene
Previous Symbols for FKBP1B Gene
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for FKBP1B Gene
FKBP1B (FK506 Binding Protein 1B, 12.6 KDa) is a Protein Coding gene. Diseases associated with FKBP1B include catecholaminergic polymorphic ventricular tachycardia. Among its related pathways are Integrated Pancreatic Cancer Pathway and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include receptor binding and peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is FKBP1A.
UniProtKB/Swiss-Prot for FKBP1B Gene
Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides