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Aliases for FKBP1B Gene

Aliases for FKBP1B Gene

  • FK506 Binding Protein 1B, 12.6 KDa 2 3
  • 12.6 KDa FK506-Binding Protein 3 4
  • FK506-Binding Protein 1B 3 4
  • Immunophilin FKBP12.6 3 4
  • 12.6 KDa FKBP 3 4
  • PPIase FKBP1B 3 4
  • Calstabin 2 2 3
  • EC 4 63
  • FKBP-12.6 3 4
  • H-FKBP-12 3 4
  • Rotamase 3 4
  • FKBP12.6 3 4
  • FKBP-1B 3 4
  • FKBP1L 3 4
  • OTK4 3 4
  • FK506-Binding Protein 1B (12.6 KD) 2
  • FK506-Binding Protein 12.6 3
  • PPIASE 3
  • PKBP1L 3
  • FKBP9 4

External Ids for FKBP1B Gene

Previous HGNC Symbols for FKBP1B Gene

  • FKBP1L

Previous GeneCards Identifiers for FKBP1B Gene

  • GC02P024188
  • GC02P024365
  • GC02P024230
  • GC02P024248
  • GC02P024249
  • GC02P024184
  • GC02P024126
  • GC02P024272

Summaries for FKBP1B Gene

Entrez Gene Summary for FKBP1B Gene

  • The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for FKBP1B Gene

FKBP1B (FK506 Binding Protein 1B, 12.6 KDa) is a Protein Coding gene. Diseases associated with FKBP1B include catecholaminergic polymorphic ventricular tachycardia. Among its related pathways are Integrated Pancreatic Cancer Pathway and Transport to the Golgi and subsequent modification. GO annotations related to this gene include receptor binding and peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is FKBP1A.

UniProtKB/Swiss-Prot for FKBP1B Gene

  • Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides

Gene Wiki entry for FKBP1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBP1B Gene

Genomics for FKBP1B Gene

Regulatory Elements for FKBP1B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FKBP1B Gene

24,049,701 bp from pter
24,067,743 bp from pter
18,043 bases
Plus strand

Genomic View for FKBP1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FKBP1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP1B Gene

Proteins for FKBP1B Gene

  • Protein details for FKBP1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP1B
    Protein Accession:
    Secondary Accessions:
    • Q13664
    • Q16645
    • Q53TM2
    • Q9BQ40

    Protein attributes for FKBP1B Gene

    108 amino acids
    Molecular mass:
    11783 Da
    Quaternary structure:
    • Identified in a complex composed of RYR2, FKBP1B, PKA catalytic subunit, PRKAR2A, AKAP6, and the protein phosphatases PP2A and PP1. Interacts directly with RYR2.

    Three dimensional structures from OCA and Proteopedia for FKBP1B Gene

    Alternative splice isoforms for FKBP1B Gene


neXtProt entry for FKBP1B Gene

Proteomics data for FKBP1B Gene at MOPED

Selected DME Specific Peptides for FKBP1B Gene

Post-translational modifications for FKBP1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FKBP1B Gene

Antibody Products

Domains & Families for FKBP1B Gene

Gene Families for FKBP1B Gene

Protein Domains for FKBP1B Gene


Suggested Antigen Peptide Sequences for FKBP1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PPIase FKBP-type domain.
  • Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
  • Contains 1 PPIase FKBP-type domain.
  • Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
genes like me logo Genes that share domains with FKBP1B: view

Function for FKBP1B Gene

Molecular function for FKBP1B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0)
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by both FK506 and rapamycin
UniProtKB/Swiss-Prot Function:
Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides

Enzyme Numbers (IUBMB) for FKBP1B Gene

Gene Ontology (GO) - Molecular Function for FKBP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IDA 7513996
GO:0005102 receptor binding IPI 10830164
GO:0005219 contributes_to ryanodine-sensitive calcium-release channel activity TAS 11322937
GO:0005515 protein binding IPI 7592869
GO:0005528 FK506 binding IDA 7592869
genes like me logo Genes that share ontologies with FKBP1B: view
genes like me logo Genes that share phenotypes with FKBP1B: view

Animal Models for FKBP1B Gene

MGI Knock Outs for FKBP1B:

Animal Model Products

miRNA for FKBP1B Gene

miRTarBase miRNAs that target FKBP1B

No data available for Transcription Factor Targets and HOMER Transcription for FKBP1B Gene

Localization for FKBP1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP1B Gene

Cytoplasm. Sarcoplasmic reticulum.

Subcellular locations from

Jensen Localization Image for FKBP1B Gene COMPARTMENTS Subcellular localization image for FKBP1B gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for FKBP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12443530
GO:0005829 cytosol IC 7592869
GO:0016020 membrane IDA 12443530
GO:0016529 sarcoplasmic reticulum --
GO:0030018 Z disc IDA 20431056
genes like me logo Genes that share ontologies with FKBP1B: view

Pathways & Interactions for FKBP1B Gene

genes like me logo Genes that share pathways with FKBP1B: view

Gene Ontology (GO) - Biological Process for FKBP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IDA 7513996
GO:0002027 regulation of heart rate --
GO:0006457 protein folding --
GO:0006458 de novo protein folding TAS 11322937
GO:0006939 smooth muscle contraction IEA --
genes like me logo Genes that share ontologies with FKBP1B: view

No data available for SIGNOR curated interactions for FKBP1B Gene

Drugs & Compounds for FKBP1B Gene

(7) Drugs for FKBP1B Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carvedilol Approved, Investigational Pharma Antagonist 149
Isoproterenol Approved Pharma Full agonist, Agonist 15
Tacrolimus Approved, Investigational Pharma 992
Caffeine Approved Nutra Activator 317
Rapamycin Pharma mTOR inhibitor 0

(1) Additional Compounds for FKBP1B Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FKBP1B: view

Transcripts for FKBP1B Gene

Unigene Clusters for FKBP1B Gene

FK506 binding protein 1B, 12.6 kDa:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FKBP1B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP1B Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h · 6i
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: - - - -

Relevant External Links for FKBP1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FKBP1B Gene

mRNA expression in normal human tissues for FKBP1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FKBP1B Gene

This gene is overexpressed in Fetal Brain (46.4), Frontal cortex (9.0), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FKBP1B Gene

SOURCE GeneReport for Unigene cluster for FKBP1B Gene Hs.709461

mRNA Expression by UniProt/SwissProt for FKBP1B Gene

Tissue specificity: Detected in heart muscle (at protein level). Isoform 1 and isoform 2 are ubiquitous with highest levels in brain and thymus.
genes like me logo Genes that share expression patterns with FKBP1B: view

Protein tissue co-expression partners for FKBP1B Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for FKBP1B Gene

Orthologs for FKBP1B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FKBP1B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FKBP1B 35
  • 95.37 (n)
  • 100 (a)
  • 100 (a)
(Canis familiaris)
Mammalia FKBP1B 35
  • 97.22 (n)
  • 100 (a)
  • 77 (a)
(Mus musculus)
Mammalia Fkbp1b 35
  • 94.44 (n)
  • 97.22 (a)
Fkbp1b 16
Fkbp1b 36
  • 97 (a)
(Pan troglodytes)
Mammalia FKBP1B 35
  • 100 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Fkbp1b 35
  • 93.83 (n)
  • 99.07 (a)
(Monodelphis domestica)
Mammalia FKBP1B 36
  • 94 (a)
(Gallus gallus)
Aves FKBP1B 35
  • 86.11 (n)
  • 91.67 (a)
  • 85 (a)
(Anolis carolinensis)
Reptilia FKBP1B 36
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fkbp1b 35
  • 80.56 (n)
  • 89.81 (a)
Str.15290 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.21934 35
(Danio rerio)
Actinopterygii fkbp1b 35
  • 78.4 (n)
  • 91.67 (a)
zgc73381 35
fkbp1b 36
  • 92 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11606 35
fruit fly
(Drosophila melanogaster)
Insecta FK506-bp2 37
  • 69 (a)
FK506-bp2 36
  • 70 (a)
(Caenorhabditis elegans)
Secernentea fkb-2 36
  • 56 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPR1 36
  • 53 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3865 36
  • 71 (a)
Species with no ortholog for FKBP1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FKBP1B Gene

Gene Tree for FKBP1B (if available)
Gene Tree for FKBP1B (if available)

Paralogs for FKBP1B Gene

Paralogs for FKBP1B Gene Pseudogenes for FKBP1B Gene

genes like me logo Genes that share paralogs with FKBP1B: view

Variants for FKBP1B Gene

Sequence variations from dbSNP and Humsavar for FKBP1B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs14388 -- 24,063,319(+) GGCAT(C/T)ATCCA utr-variant-3-prime, intron-variant
rs15346 -- 24,063,520(+) ACACA(C/T)ACAAG utr-variant-3-prime, intron-variant
rs1050273 -- 24,063,458(+) CTGAT(A/G)ACAGA utr-variant-3-prime, intron-variant
rs1148946 -- 24,059,727(+) catct(C/G/T)tacta intron-variant
rs1424344 -- 24,061,096(+) CACCC(C/T)TCTCC intron-variant

Variation tolerance for FKBP1B Gene

Residual Variation Intolerance Score: 43.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FKBP1B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FKBP1B Gene

Disorders for FKBP1B Gene

MalaCards: The human disease database

(1) MalaCards diseases for FKBP1B Gene - From: NovoSeek and GeneCards

Disorder Aliases PubMed IDs
catecholaminergic polymorphic ventricular tachycardia
  • ventricular tachycardia, catecholaminergic polymorphic, 1
- elite association

Relevant External Links for FKBP1B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FKBP1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FKBP1B Gene

Publications for FKBP1B Gene

  1. Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts. (PMID: 7513996) Arakawa H. … Nakamura Y. (Biochem. Biophys. Res. Commun. 1994) 2 23 67
  2. Adenovirus-mediated FKBP12.6 overexpression induces hypertrophy and apoptosis in cultured neonatal cardiomyocytes. (PMID: 18759859) Zhong J. … Zhu Z. (Clin. Exp. Pharmacol. Physiol. 2009) 23 67
  3. Deficiency of testosterone associates with the substrate of atrial fibrillation in the rat model. (PMID: 19460074) Tsuneda T. … Inoue H. (J. Cardiovasc. Electrophysiol. 2009) 23 67
  4. Search for cardiac calcium cycling gene mutations in familial ventricular arrhythmias resembling catecholaminergic polymorphic ventricular tachycardia. (PMID: 19216760) Marjamaa A. … Swan H. (BMC Med. Genet. 2009) 23 67
  5. Genetic characterization of familial CPVT after 30 years. (PMID: 19398417) Beery T.A. … Benson D.W. (Biol Res Nurs 2009) 23 67

Products for FKBP1B Gene

Sources for FKBP1B Gene

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