FKBP1B Gene
protein-coding GIFtS: 56
GCID: GC02P024272
|
|
FK506 binding protein 1B, 12.6 kDa(Previous name: FK506-binding protein 1B (12.6 kD) )
(Previous symbol: FKBP1L)
| |
Aliases
for FKBP1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| FK506 Binding Protein 1B, 12.6 KDa1 2 | | FK506-Binding Protein 1B2 3 | | FKBP12.61 2 3 | | H-FKBP-121 | | FKBP1L1 2 3 | | PPIase FKBP1B2 3 | | OTK41 2 3 | | EC 5.2.1.83 8 | | PPIase1 2 | | PKBP1L2 5 | | FKBP91 3 | | FK506-Binding Protein 1B (12.6 KD)1 | | Immunophilin FKBP12.62 3 | | Calstabin 22 | | 12.6 KDa FK506-Binding Protein2 3 | | FK506-Binding Protein 12.62 | | 12.6 KDa FKBP2 3 | | Peptidyl-Prolyl Cis-Trans Isomerase FKBP1B2 | | FKBP-12.62 3 | | Rotamase3 | | FKBP-1B2 3 | | Rotamase3 |
Export aliases for FKBP1B gene to outside databasesPrevious GC identifers: GC02P024188 GC02P024365 GC02P024230 GC02P024248 GC02P024249 GC02P024184 GC02P024126 GC02P024011 |
Summaries
for FKBP1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FKBP1B:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulationand basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolylisomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A.Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are twoalternatively spliced transcript variants of this gene encoding different isoforms. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: FKB1B_HUMAN, P68106Function: Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIasesaccelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds inoligopeptides
Gene Wiki entry for FKBP1B
|
Genomic Views
for FKBP1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FKBP1B gene promoter:
FOXC1 Sp1 RREB-1 YY1 Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FKBP1B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FKBP1B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p23.3 Ensembl cytogenetic band: 2p23.3 HGNC cytogenetic band: 2p23.3FKBP1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P024272: view genomic region
(about GC identifiers)
Start:
|
24,272,571 bp from pter |
End:
|
24,286,551 bp from pter |
Size:
|
13,981 bases |
Orientation:
|
plus strand |
|
Proteins
for FKBP1B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FKB1B_HUMAN, P68106 (See
protein sequence)Recommended Name: Peptidyl-prolyl cis-trans isomerase FKBP1B Size: 108 amino acids; 11783 Da
Subunit: Identified in a complex composed of RYR2, FKBP1B, PKA catalytic subunit, PRKAR2A, AKAP6, and the proteinphosphatases PP2A and PP1. Interacts directly with RYR2
Subcellular location: Cytoplasm (By similarity). Sarcoplasmic reticulum (By similarity)
1 PDB 3D structure from  and Proteopedia  for FKBP1B:1C9H (3D)
Secondary accessions: Q13664 Q16645 Q53TM2 Q9BQ40Alternative splicing: 2 isoforms: P68106-1, Q16645-1 P68106-2, Q16645-2 Explore the universe of human proteins at neXtProt for FKBP1B: NX_P68106
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P68106
4/7 DME Specific Peptides for FKBP1B (P68106) (see all 7)
FKBP1B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_004107.1 NP_473374.1
ENSEMBL proteins: ENSP00000370379 ENSP00000370373 ENSP00000416349 ENSP00000406593 ENSP00000397444
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
FKBP1B for ontologies About GeneDecksing
FKBP1B Antibody Products:
Assay Products for FKBP1B: |
Protein
Domains /
Families
for FKBP1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FKBP1B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P68106ProtoNet protein and cluster: P68106 UniProtKB/Swiss-Prot: FKB1B_HUMAN, P68106Similarity: Belongs to the FKBP-type PPIase family. FKBP1 subfamilySimilarity: Contains 1 PPIase FKBP-type domain |
Function
for FKBP1B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FKB1B_HUMAN, P68106Function: Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIasesaccelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds inoligopeptidesCatalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)Enzyme regulation: Inhibited by both FK506 and rapamycinEnzyme Number (IUBMB): EC 5.2.1.81 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP1B (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP1B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for FKBP1B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FKBP1B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBP1B |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
FKBP1B for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for FKBP1B: Fkbp1btm1Syf Fkbp1btm1Amks Fkbp1btm1.1Okam
6 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Fkbp1b):
FKBP1B for phenotypes About GeneDecksing
|
Pathways & Interactions
for FKBP1B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Integrated Pancreatic Cancer Pathway | | | 2 | Antiarrhythmic Pathway, Pharmacodynamics | |
2  BioSystems Pathways for FKBP1B
1  PharmGKB Pathway for FKBP1B
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FKBP1B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/41 Interacting proteins for FKBP1B (P681063 ENSP000003703734) via UniProtKB, MINT, STRING, and/or I2D (see all 41)About this table
Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27): About this table
FKBP1B for ontologies About GeneDecksing
|
Drugs & Compounds
for FKBP1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
FKBP1B for compounds About GeneDecksing
 Browse Tocris compounds for FKBP1B
8 Novoseek chemical compound relationships for FKBP1B gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ryanodine |
90.7 |
32 |
9176165 (3), 8702774 (2), 12446682 (2), 10336416 (1) (see all 21) |
| tacrolimus |
72.2 |
21 |
7592869 (3), 17313373 (3), 8702774 (2), 15497458 (2) (see all 14) |
| calcium |
58.8 |
28 |
17313373 (6), 15967847 (2), 7527548 (2), 8702774 (1) (see all 17) |
| rapamycin |
52.7 |
9 |
8413204 (3), 7592869 (2), 12443530 (1), 18759859 (1) |
| carvedilol |
41.7 |
1 |
16191273 (1) |
| caffeine |
25.8 |
1 |
12919952 (1) |
| isoproterenol |
12.8 |
1 |
12919952 (1) |
| lipid |
5.67 |
4 |
9176165 (1), 7527548 (1), 11397781 (1), 12743001 (1) |
Search CenterWatch for drugs/clinical trials and news about FKBP1B / FKB1B
|
Transcripts
for FKBP1B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FKBP1B gene (2 alternative transcripts): NM_004116.3 NM_054033.2 Unigene Cluster for FKBP1B: FK506 binding protein 1B, 12.6 kDa Hs.709461 [show with all ESTs]Unigene Representative Sequence: BM5466466 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000380991(uc002res.3) ENST00000380986(uc002rer.3) ENST00000438630(uc002ret.3)
ENST00000496149 ENST00000452109 ENST00000421839
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP1B (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP1B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FKBP1B (NM_004116) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FKBP1B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FKBP1B |
Additional cDNA sequence: AF322070.1 BC002614.1 BC050998.1 D38037.1 L37086.1 S69800.1 S69815.1 9 DOTS entries: DT.97840020 DT.92420248 DT.314208 DT.101972009 DT.100778876 DT.92420247 DT.100675719 DT.100739403 DT.99969818 24/106 AceView cDNA sequences (see all 106): AW440529 BF969580 AF322070 AI002601 BM709528 BQ001343 BX644798 AA403064 AI352461 CR614690 BM802489 BQ719265 CR626535 AI350209 NM_054033 N57494 AA778361 AA831473 AA760992 L37086 CR616275 AI078220 BC033385 AI347804
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for FKBP1B (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | · | 6g | · | 6h | · | 6i |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | - | | | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FKBP1B
|
Expression
for FKBP1B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FKBP1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCGTACCGTA
About this image
See FKBP1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FKBP1B
SOURCE GeneReport for Unigene cluster: Hs.709461
UniProtKB/Swiss-Prot: FKB1B_HUMAN, P68106Tissue specificity: Detected in heart muscle (at protein level). Isoform 1 and isoform 2 are ubiquitous with highestlevels in brain and thymus
SABiosciences Custom PCR Arrays for FKBP1B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FKBP1B
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBP1B |
Orthologs
for FKBP1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for FKBP1B gene from 9/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FKBP1B1 |
FK506 binding protein 1B, 12.6 kDa |
86.11(n)
91.67(a) |
|
395254 NM_204567.1 NP_989898.1 |
lizard
(Anolis carolinensis) |
Reptilia |
FKBP1B6 |
-- |
92(a) |
1 ↔ 1 |
1(140216928-140246606) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.219342 |
Xenopus laevis, Similar to FK506 binding protein 1B, more |
81.54(n) |
|
BC041748.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc733812 |
hypothetical protein MGC73381 |
80.25(n) |
|
393785 BC059689.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
FK506-bp23 |
protein folding FK506 binding |
69(a) |
|
56C8 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
fkb-26fkb-86 |
FK506-Binding protein family member (fkb-8) |
56(a)16(a) |
possible orthologpossible ortholog |
I(12918709-12919282) I(12916431-12918098) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT3G555206 |
FKBP-like peptidyl-prolyl cis-trans isomerase fami... |
20(a) |
possible ortholog |
3(20593661-20595345) |
rice
(Oryza sativa) |
Liliopsida |
---- |
peptidyl-prolyl cis-trans isomerase, FKBP-type, pu...peptidyl-prolyl cis-trans isomerase, FKBP-type, pu... |
22(a)22(a) |
possible orthologpossible ortholog |
1(36252504-36255934) 5(22429840-22432453) |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
fklB6fkpA6 |
FKBP-type peptidyl-prolyl cis-trans isomerase (rot...FKBP-type peptidyl-prolyl cis-trans isomerase (rot... |
19(a)16(a) |
possible orthologpossible ortholog |
Chromosome(4426958-4427578) Chromosome(3474629-3475441) |
ENSEMBL Gene Tree for FKBP1B (if available)
TreeFam Gene Tree for FKBP1B (if available) |
Paralogs
for FKBP1B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FKBP1B gene
- FKBP52 FKBP1A2 FKBP42 FKBP1C2 FKBP82 FKBP62 FKBP32
16 SIMAP similar genes for FKBP1B using alignment to 4 protein entries: FKB1B_HUMAN (see all proteins):FKBP12-Exip3 FKBP12-Exin FKBP1A FKBP1C FKBP12-Exip2 FKBP5
FKBP4 FKBP2 FKBP6 FKBP10 FKBP9 DKFZp666D193
FKBP11 FKBP14 FKBP7 FKBP8
FKBP1B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for FKBP1B
PGOHUM00000248148
|
Genomic Variants
for FKBP1B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FKBP1B (24272571 - 24286551 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FKBP1B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FKBP1B |
|
Disorders
/ Diseases
for FKBP1B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FKBP1B for disorders About GeneDecksing
OMIM gene information: 600620
OMIM disorders: --
15  diseases for FKBP1B: About MalaCardscatecholaminergic polymorphic ventricular tachycardia arrhythmogenic right ventricular dysplasia ventricular tachycardia left ventricular noncompaction
long qt syndrome hypertrophic cardiomyopathy familial hypertrophic cardiomyopathy ventricular fibrillation
atrial fibrillation essential hypertension cardiomyopathy hypertension
thyroiditis neuronitis septic shock
6 Novoseek disease relationships for FKBP1B gene About this table
Genetic Association Database (GAD): FKBP1B
Human Genome Epidemiology (HuGE) Navigator: FKBP1B (1 document)
Export disorders for FKBP1B gene to outside databases
|
Publications
for FKBP1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FKBP1B gene, integrated from 9 sources (see all 76):
(articles sorted by number of sources associating them with FKBP1B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts. (PubMed id 7513996)1, 2, 3, 9 Arakawa H....Nakamura Y. (1994)
- Genomic organization, chromosomal localization, and promoter of human gene for FK506-binding protein 12.6. (PubMed id 16122887)1, 2, 9 Nakazawa T.... Okamoto H. (2005)
- A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor. (PubMed id 7592869)1, 2, 9 Lam E.... Wiederrecht G.J. (1995)
- PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. (PubMed id 10830164)1, 2, 9 Marx S.O....Marks A.R. (2000)
- Association of EDNRA, but not WNK4 or FKBP1B, polymorphisms with essential hypertension. (PubMed id 14616768)1, 4, 9 Benjafield A.V....Morris B.J. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Structure of FKBP12.6 in complex with rapamycin. (PubMed id 10713512)1, 2 Deivanayagam C.C....Chodavarapu R.S. (2000)
- K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. (PubMed id 17313373)1, 9 Hunt D.J....Chen S.R. (2007)
- In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6. (PubMed id 12443530)1, 9 George C.H....Lai F.A. (2003)
- Interaction of FKBP12.6 with the cardiac ryanodine receptor C-terminal domain. (PubMed id 15591045)1, 9 Zissimopoulos S. and Lai F.A. (2005)
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External Searches for FKBP1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing FKBP1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing FKBP1B gene
(According to HUGE)
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Specialized Databases showing FKBP1B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for FKBP1B | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for FKBP1B gene:
Search GeneIP for patents involving FKBP1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for FKBP1B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FKBP1B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FKBP1B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FKBP1B | | | OriGene Protein Over-expression Lysate for FKBP1B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FKBP1B | | OriGene 3'-UTR Clone for FKBP1B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP1B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP1B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FKBP1B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FKBP1B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FKBP1B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FKBP1B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FKBP1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FKBP1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FKBP1B |
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| | | | Search Tocris compounds for FKBP1B |
| |  |  |  |  | | | | | | Recombinant Protein for FKBP1B |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBP1B |
|  |  |  | | | | Search ThermoFisher Antibodies for FKBP1B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FKBP1B |
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