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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FKBP1B Gene

protein-coding   GIFtS: 53
GCID: GC02P024272

FK506 Binding Protein 1B, 12.6 KDa

(Previous name: FK506-binding protein 1B (12.6 kD))
(Previous symbol: FKBP1L)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
FK506 Binding Protein 1B, 12.6 KDa1 2     h-FKBP-122 3
FKBP1L1 2 3     PPIase FKBP1B2 3
Calstabin 21 2     EC 5.2.1.83 8
Immunophilin FKBP12.62 3     PKBP1L2 5
12.6 KDa FK506-Binding Protein2 3     FK506-Binding Protein 1B (12.6 KD)1
12.6 KDa FKBP2 3     PPIase2
FKBP-12.62 3     FK506-Binding Protein 12.62
FKBP-1B2 3     Peptidyl-Prolyl Cis-Trans Isomerase FKBP1B2
FKBP12.62 3     rotamase2
OTK42 3     FKBP93
FK506-Binding Protein 1B2 3     Rotamase3

External Ids:    HGNC: 37121   Entrez Gene: 22812   Ensembl: ENSG000001197827   OMIM: 6006205   UniProtKB: P681063   

Export aliases for FKBP1B gene to outside databases

Previous GC identifers: GC02P024188 GC02P024365 GC02P024230 GC02P024248 GC02P024249 GC02P024184 GC02P024126 GC02P024011


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FKBP1B Gene:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in
immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is
a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the
FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac
muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms.
(provided by RefSeq, Jul 2008)

GeneCards Summary for FKBP1B Gene: 
FKBP1B (FK506 binding protein 1B, 12.6 kDa) is a protein-coding gene. Diseases associated with FKBP1B include catecholaminergic polymorphic ventricular tachycardia, and left ventricular noncompaction. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and receptor binding. An important paralog of this gene is FKBP5.

UniProtKB/Swiss-Prot: FKB1B_HUMAN, P68106
Function: Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin.
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide
bonds in oligopeptides

Gene Wiki entry for FKBP1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FKBP1B gene promoter:
         FOXC1   Sp1   RREB-1   YY1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFKBP1B promoter sequence
   Search SABiosciences Chromatin IP Primers for FKBP1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FKBP1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23.3

FKBP1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FKBP1B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P024272:  view genomic region     (about GC identifiers)

Start:
24,272,571 bp from pter      End:
24,286,551 bp from pter
Size:
13,981 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FKB1B_HUMAN, P68106 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase FKBP1B  
Size: 108 amino acids; 11783 Da
Subunit: Identified in a complex composed of RYR2, FKBP1B, PKA catalytic subunit, PRKAR2A, AKAP6, and the protein
phosphatases PP2A and PP1. Interacts directly with RYR2
Subcellular location: Cytoplasm (By similarity). Sarcoplasmic reticulum (By similarity)
1 PDB 3D structure from and Proteopedia for FKBP1B:
1C9H (3D)    
Secondary accessions: Q13664 Q16645 Q53TM2 Q9BQ40
Alternative splicing: 2 isoforms:  P68106-1, Q16645-1   P68106-2, Q16645-2   

Explore the universe of human proteins at neXtProt for FKBP1B: NX_P68106

Explore proteomics data for FKBP1B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P68106

  • 4/7 DME Specific Peptides for FKBP1B (P68106) (see all 7)
     GKKFDSS  TLIFDVE  IPPNATL  KFDSSRDR 

    FKBP1B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FKBP1B Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_004107.1  NP_473374.1  

    ENSEMBL proteins: 
     ENSP00000370379   ENSP00000370373   ENSP00000416349   ENSP00000406593   ENSP00000397444  

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    Cloud-Clone Corp. Proteins for FKBP1B 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA12443530
    GO:0005829cytosol IC7592869
    GO:0016020membrane IDA12443530
    GO:0016529sarcoplasmic reticulum ----
    GO:0030018Z disc IDA--

    FKBP1B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR023566 PPIase_FKBP
     IPR001179 PPIase_FKBP_dom

    Graphical View of Domain Structure for InterPro Entry P68106

    ProtoNet protein and cluster: P68106

    UniProtKB/Swiss-Prot: FKB1B_HUMAN, P68106
    Similarity: Belongs to the FKBP-type PPIase family. FKBP1 subfamily
    Similarity: Contains 1 PPIase FKBP-type domain


    FKBP1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FKB1B_HUMAN, P68106
    Function: Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin.
    PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide
    bonds in oligopeptides
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)
    Enzyme regulation: Inhibited by both FK506 and rapamycin

         Enzyme Number (IUBMB): EC 5.2.1.81 2

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity IDA7513996
    GO:0005102receptor binding IPI10830164
    GO:0005219contributes to ryanodine-sensitive calcium-release channel activity TAS11322937
    GO:0005515protein binding IPI7592869
    GO:0005528FK506 binding IDA7592869
         
    FKBP1B for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Fkbp1b):
     cardiovascular system  endocrine/exocrine gland  homeostasis/metabolism  mortality/aging  muscle 
     no phenotypic analysis 

    FKBP1B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for FKBP1B: Fkbp1btm1Syf Fkbp1btm1Amks Fkbp1btm1.1Okam

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FKBP1B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Antiarrhythmic Pathway, Pharmacodynamics
    Antiarrhythmic Pathway, Pharmacodynamics
    2Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway


    1 BioSystems Pathway for FKBP1B
        Integrated Pancreatic Cancer Pathway

    1 PharmGKB Pathway for FKBP1B
        Antiarrhythmic Pathway, Pharmacodynamics

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FKBP1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/42 Interacting proteins for FKBP1B (P681063 ENSP000003703734) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RYR2Q927363, ENSP000003555334I2D: score=2 STRING: ENSP00000355533
    BMPR1AP368943I2D: score=1 
    AKAP6ENSP000002809794STRING: ENSP00000280979
    CACNA1BENSP000002775494STRING: ENSP00000277549
    CACNA1CENSP000002663764STRING: ENSP00000266376
    About this table

    Gene Ontology (GO): 5/32 biological process terms (GO ID links to tree view) (see all 32):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000413protein peptidyl-prolyl isomerization IDA7513996
    GO:0002027regulation of heart rate ----
    GO:0006457protein folding ----
    GO:0006458'de novo' protein folding TAS11322937
    GO:0006936muscle contraction NAS--

    FKBP1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FKBP1B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for FKBP1B (FKB1B)

    8 Novoseek inferred chemical compound relationships for FKBP1B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ryanodine 90.7 32 9176165 (3), 8702774 (2), 12446682 (2), 10336416 (1) (see all 21)
    tacrolimus 72.2 21 7592869 (3), 17313373 (3), 8702774 (2), 15497458 (2) (see all 14)
    calcium 58.8 28 17313373 (6), 15967847 (2), 7527548 (2), 8702774 (1) (see all 17)
    rapamycin 52.7 9 8413204 (3), 7592869 (2), 12443530 (1), 18759859 (1)
    carvedilol 41.7 1 16191273 (1)
    caffeine 25.8 1 12919952 (1)
    isoproterenol 12.8 1 12919952 (1)
    lipid 5.67 4 9176165 (1), 7527548 (1), 11397781 (1), 12743001 (1)

    Search CenterWatch for drugs/clinical trials and news about FKBP1B / FKB1B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FKBP1B gene (2 alternative transcripts): 
    NM_004116.3  NM_054033.2  

    Unigene Cluster for FKBP1B:

    FK506 binding protein 1B, 12.6 kDa
    Hs.709461  [show with all ESTs]
    Unigene Representative Sequence: BM546646
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380991(uc002res.3) ENST00000380986(uc002rer.3) ENST00000438630(uc002ret.3)
    ENST00000496149 ENST00000452109 ENST00000421839
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    Additional mRNA sequence: 

    AF322070.1 BC002614.1 BC050998.1 D38037.1 L37086.1 S69800.1 S69815.1 

    9 DOTS entries:

    DT.97840020  DT.92420248  DT.314208  DT.101972009  DT.100778876  DT.92420247  DT.100675719  DT.100739403 
    DT.99969818 

    24/106 AceView cDNA sequences (see all 106):

    CR626535 BQ001343 AA760992 AF322070 CR616275 BQ448196 BC033385 BM716287 
    CR607749 AA403064 BM802489 CR614690 AI347804 BC050998 BX644798 L37086 
    AI352461 BM709528 N57494 AI002601 AA778361 BC002614 NM_054033 AA831473 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for FKBP1B (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h · 6i
    SP1:                                                        -           -                                                               
    SP2:                                                        -     -     -                                                               
    SP3:                                                  -     -           -           -                                                   
    SP4:                                                  -     -     -     -                                                               
    SP5:                                                  -     -     -     -           -                                                   


    ECgene alternative splicing isoforms for FKBP1B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FKBP1B expression in normal human tissues (normalized intensities)      FKBP1B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGTACCGTA
    FKBP1B Expression
    About this image


    FKBP1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Brain (Nervous System)

    See FKBP1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FKBP1B

    SOURCE GeneReport for Unigene cluster: Hs.709461

    UniProtKB/Swiss-Prot: FKB1B_HUMAN, P68106
    Tissue specificity: Detected in heart muscle (at protein level). Isoform 1 and isoform 2 are ubiquitous with
    highest levels in brain and thymus

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBP1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FKBP1B gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fkbp1b1 , 5 FK506 binding protein 1b1, 5 94.44(n)1
    97.22(a)1
      12 (2.09 cM)5
    142261  NM_016863.31  NP_058559.31 
     48331755 
    chicken
    (Gallus gallus)
    Aves FKBP1B1 FK506 binding protein 1B, 12.6 kDa 86.11(n)
    91.67(a)
      395254  NM_204567.1  NP_989898.1 
    lizard
    (Anolis carolinensis)
    Reptilia FKBP1B6
    Peptidyl-prolyl cis-trans isomerase
    92(a)
    1 ↔ 1
    1(140216925-140246606)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.219342 Xenopus laevis, Similar to FK506 binding protein 1B, more 81.54(n)    BC041748.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc733812 hypothetical protein MGC73381 80.25(n)   393785  BC059689.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta FK506-bp23 protein folding FK506 binding 69(a)   56C8   --
    worm
    (Caenorhabditis elegans)
    Secernentea fkb-26
    fkb-86
    Protein FKB-8
    56(a)
    15(a)
    possible ortholog
    possible ortholog
    I(12918720-12919293)
    I(12916441-12918109)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FPR16
    Peptidyl-prolyl cis-trans isomerase (PPIase), bind...
    52(a)
    1 → many
    XIV(371882-372226)


    ENSEMBL Gene Tree for FKBP1B (if available)
    TreeFam Gene Tree for FKBP1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FKBP1B gene
    FKBP52  FKBP1A2  FKBP1C2  FKBP42  FKBP82  FKBP62  FKBP32  
    16 SIMAP similar genes for FKBP1B using alignment to 4 protein entries:     FKB1B_HUMAN (see all proteins):
    FKBP12-Exip3    FKBP12-Exin    FKBP1A    FKBP1C    FKBP12-Exip2    FKBP5
    FKBP4    FKBP2    FKBP6    FKBP10    FKBP9    DKFZp666D193
    FKBP11    FKBP14    FKBP7    FKBP8

    FKBP1B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FKBP1B
    PGOHUM00000248148


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/256 SNPs in FKBP1B are shown (see all 256)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs134134501,2
    C,F,H--24272396(+) GAATGG/TATGGA 2 -- us2k1 tfbs38Minor allele frequency- T:0.07EA NS NA CSA 412
    rs1488765811,2
    --24272462(+) GCGGGA/GCCAGG 2 -- us2k10--------
    rs1165207861,2
    C,F--24272645(+) GACGGC/TGGGGC 2 -- ut511Minor allele frequency- T:0.25NA 120
    rs1116341631,2
    C,F--24272657(+) GGGGCT/CGGAGC 2 -- ut511Minor allele frequency- C:0.00CSA 1
    rs116781391,2
    H--24273393(+) TACGGC/GCGAAC 2 -- int10--------
    rs1475838851,2
    --24273399(+) CGAACA/CTCTCC 2 -- int10--------
    rs1836418221,2
    --24273529(+) ATTACA/TGGGTC 2 -- int10--------
    rs1420921551,2
    --24273594(+) AGCCCC/GCATTG 2 -- int10--------
    rs37696681,2
    C,F,H--24273600(-) TGCAGA/GCAATG 2 -- int113Minor allele frequency- G:0.07EA NS NA 3062
    rs1887767231,2
    --24273675(+) TGGATA/TACTTC 2 -- int10--------

    HapMap Linkage Disequilibrium report for FKBP1B (24272571 - 24286551 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FKBP1B: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FKBP1B
    DNA2.0 Custom Variant and Variant Library Synthesis for FKBP1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600620    OMIM disorders: --

    13 diseases for FKBP1B:    About MalaCards
    catecholaminergic polymorphic ventricular tachycardia    left ventricular noncompaction    arrhythmogenic right ventricular dysplasia    familial hypertrophic cardiomyopathy
    long qt syndrome    hypertrophic cardiomyopathy    essential hypertension    dilated cardiomyopathy
    hypertension    thyroiditis    pancreatic cancer    neuronitis
    pancreatitis


    FKBP1B for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for FKBP1B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ventricular tachycardia, catecholaminergic polymorphic 91.6 1 12837242 (1)
    death sudden cardiac 66.4 1 12837242 (1)
    arrhythmia 59.5 3 12837242 (1), 17606610 (1), 15073377 (1)
    death sudden 57.3 1 17313373 (1)
    heart failure 56.8 8 12743001 (2), 16191273 (1), 17606610 (1), 15073377 (1) (see all 7)
    tachycardia ventricular 42.6 1 17313373 (1)

    Genetic Association Database (GAD): FKBP1B
    Human Genome Epidemiology (HuGE) Navigator: FKBP1B (1 document)

    Export disorders for FKBP1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FKBP1B gene, integrated from 9 sources (see all 76):
    (articles sorted by number of sources associating them with FKBP1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts. (PubMed id 7513996)1, 2, 3, 9 Arakawa H....Nakamura Y. (1994)
    2. Genomic organization, chromosomal localization, and promoter of human gene for FK506-binding protein 12.6. (PubMed id 16122887)1, 2, 9 Nakazawa T.... Okamoto H. (2005)
    3. A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor. (PubMed id 7592869)1, 2, 9 Lam E.... Wiederrecht G.J. (1995)
    4. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. (PubMed id 10830164)1, 2, 9 Marx S.O....Marks A.R. (2000)
    5. Association of EDNRA, but not WNK4 or FKBP1B, polymorphisms with essential hypertension. (PubMed id 14616768)1, 4, 9 Benjafield A.V....Morris B.J. (2003)
    6. Genome-wide association studies in an isolated founde r population from the Pacific Island of Kosrae. (PubMed id 19197348)1, 4 Lowe J.K....Friedman J.M. (2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Structure of FKBP12.6 in complex with rapamycin. (PubMed id 10713512)1, 2 Deivanayagam C.C....Chodavarapu R.S. (2000)
    9. K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. (PubMed id 17313373)1, 9 Hunt D.J....Chen S.R. (2007)
    10. In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6. (PubMed id 12443530)1, 9 George C.H....Lai F.A. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2281 HGNC: 3712 AceView: FKBP1B Ensembl:ENSG00000119782 euGenes: HUgn2281
    ECgene: FKBP1B H-InvDB: FKBP1B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FKBP1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FKBP1B gene:
    Search GeneIP for patents involving FKBP1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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