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Aliases for FKBP1B Gene

Aliases for FKBP1B Gene

  • FK506 Binding Protein 1B, 12.6 KDa 2 3
  • 12.6 KDa FK506-Binding Protein 3 4
  • FK506-Binding Protein 1B 3 4
  • Immunophilin FKBP12.6 3 4
  • 12.6 KDa FKBP 3 4
  • PPIase FKBP1B 3 4
  • Calstabin 2 2 3
  • EC 5.2.1.8 4 64
  • FKBP-12.6 3 4
  • H-FKBP-12 3 4
  • Rotamase 3 4
  • FKBP12.6 3 4
  • FKBP-1B 3 4
  • FKBP1L 3 4
  • PKBP1L 3 6
  • OTK4 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase FKBP1B 3
  • FK506-Binding Protein 1B (12.6 KD) 2
  • FK506-Binding Protein 12.6 3
  • PPIASE 3
  • FKBP9 4

External Ids for FKBP1B Gene

Previous Symbols for FKBP1B Gene

  • FKBP1L

Summaries for FKBP1B Gene

Entrez Gene Summary for FKBP1B Gene

  • The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for FKBP1B Gene

FKBP1B (FK506 Binding Protein 1B, 12.6 KDa) is a Protein Coding gene. Diseases associated with FKBP1B include catecholaminergic polymorphic ventricular tachycardia. Among its related pathways are Integrated Pancreatic Cancer Pathway and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include receptor binding and peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is FKBP1A.

UniProtKB/Swiss-Prot for FKBP1B Gene

  • Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides

Gene Wiki entry for FKBP1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBP1B Gene

Genomics for FKBP1B Gene

Genomic Location for FKBP1B Gene

Start:
24,049,701 bp from pter
End:
24,063,681 bp from pter
Size:
13,981 bases
Orientation:
Plus strand

Genomic View for FKBP1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FKBP1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP1B Gene

Regulatory Elements for FKBP1B Gene

Proteins for FKBP1B Gene

  • Protein details for FKBP1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P68106-FKB1B_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP1B
    Protein Accession:
    P68106
    Secondary Accessions:
    • Q13664
    • Q16645
    • Q53TM2
    • Q9BQ40

    Protein attributes for FKBP1B Gene

    Size:
    108 amino acids
    Molecular mass:
    11783 Da
    Quaternary structure:
    • Identified in a complex composed of RYR2, FKBP1B, PKA catalytic subunit, PRKAR2A, AKAP6, and the protein phosphatases PP2A and PP1. Interacts directly with RYR2.

    Three dimensional structures from OCA and Proteopedia for FKBP1B Gene

    Alternative splice isoforms for FKBP1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FKBP1B Gene

Proteomics data for FKBP1B Gene at MOPED

Selected DME Specific Peptides for FKBP1B Gene

Post-translational modifications for FKBP1B Gene

No Post-translational modifications

Other Protein References for FKBP1B Gene

Domains for FKBP1B Gene

Protein Domains for FKBP1B Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

FKB1B_HUMAN
Domain:
  • Contains 1 PPIase FKBP-type domain.:
    • P68106
Family:
  • Belongs to the FKBP-type PPIase family. FKBP1 subfamily.:
    • P68106
genes like me logo Genes that share domains with FKBP1B: view

No data available for Gene Families for FKBP1B Gene

Function for FKBP1B Gene

Molecular function for FKBP1B Gene

UniProtKB/Swiss-Prot CatalyticActivity: Peptidylproline (omega=180) = peptidylproline (omega=0)
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by both FK506 and rapamycin
UniProtKB/Swiss-Prot Function: Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides

Enzyme Numbers (IUBMB) for FKBP1B Gene

Gene Ontology (GO) - Molecular Function for FKBP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IDA 7513996
GO:0005102 receptor binding IPI 10830164
GO:0005219 contributes_to ryanodine-sensitive calcium-release channel activity TAS 11322937
GO:0005515 protein binding IPI 10830164
GO:0005528 FK506 binding IDA 7592869
genes like me logo Genes that share ontologies with FKBP1B: view
genes like me logo Genes that share phenotypes with FKBP1B: view

Animal Models for FKBP1B Gene

MGI Knock Outs for FKBP1B:

miRNA for FKBP1B Gene

miRTarBase miRNAs that target FKBP1B

No data available for Transcription Factor Targeting and HOMER Transcription for FKBP1B Gene

Localization for FKBP1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP1B Gene

Cytoplasm. Sarcoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FKBP1B Gene COMPARTMENTS Subcellular localization image for FKBP1B gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 3

Gene Ontology (GO) - Cellular Components for FKBP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12443530
GO:0005829 cytosol IC 7592869
GO:0016020 membrane IDA 12443530
GO:0016529 sarcoplasmic reticulum --
GO:0030018 Z disc IDA 20431056
genes like me logo Genes that share ontologies with FKBP1B: view

Pathways for FKBP1B Gene

genes like me logo Genes that share pathways with FKBP1B: view

Pathways by source for FKBP1B Gene

Gene Ontology (GO) - Biological Process for FKBP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IDA 7513996
GO:0002027 regulation of heart rate --
GO:0006457 protein folding --
GO:0006458 de novo protein folding TAS 11322937
GO:0006939 smooth muscle contraction IEA --
genes like me logo Genes that share ontologies with FKBP1B: view

Compounds for FKBP1B Gene

(8) Novoseek inferred chemical compound relationships for FKBP1B Gene

Compound -log(P) Hits PubMed IDs
ryanodine 90.7 25
tacrolimus 72.2 20
calcium 58.8 24
rapamycin 52.7 7
carvedilol 41.7 1
genes like me logo Genes that share compounds with FKBP1B: view

Transcripts for FKBP1B Gene

Unigene Clusters for FKBP1B Gene

FK506 binding protein 1B, 12.6 kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP1B Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h · 6i
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: - - - -
SP8:

Relevant External Links for FKBP1B Gene

GeneLoc Exon Structure for
FKBP1B
ECgene alternative splicing isoforms for
FKBP1B

Expression for FKBP1B Gene

mRNA expression in normal human tissues for FKBP1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FKBP1B Gene

SOURCE GeneReport for Unigene cluster for FKBP1B Gene Hs.709461

mRNA Expression by UniProt/SwissProt for FKBP1B Gene

P68106-FKB1B_HUMAN
Tissue specificity: Detected in heart muscle (at protein level). Isoform 1 and isoform 2 are ubiquitous with highest levels in brain and thymus.
genes like me logo Genes that share expressions with FKBP1B: view

Orthologs for FKBP1B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FKBP1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FKBP1B 36
  • 100 (n)
  • 100 (a)
FKBP1B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FKBP1B 36
  • 95.37 (n)
  • 100 (a)
FKBP1B 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FKBP1B 36
  • 97.22 (n)
  • 100 (a)
FKBP1B 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fkbp1b 36
  • 94.44 (n)
  • 97.22 (a)
Fkbp1b 16
Fkbp1b 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FKBP1B 37
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fkbp1b 36
  • 93.83 (n)
  • 99.07 (a)
chicken
(Gallus gallus)
Aves FKBP1B 36
  • 86.11 (n)
  • 91.67 (a)
FKBP1B 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FKBP1B 37
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21934 36
tropical clawed frog
(Silurana tropicalis)
Amphibia fkbp1b 36
  • 80.56 (n)
  • 89.81 (a)
Str.15290 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11606 36
zebrafish
(Danio rerio)
Actinopterygii fkbp1b 36
  • 78.4 (n)
  • 91.67 (a)
fkbp1b 37
  • 92 (a)
OneToOne
zgc73381 36
fruit fly
(Drosophila melanogaster)
Insecta FK506-bp2 37
  • 70 (a)
OneToMany
FK506-bp2 38
  • 69 (a)
worm
(Caenorhabditis elegans)
Secernentea fkb-2 37
  • 56 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPR1 37
  • 53 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3865 37
  • 71 (a)
OneToMany
Species with no ortholog for FKBP1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FKBP1B Gene

ENSEMBL:
Gene Tree for FKBP1B (if available)
TreeFam:
Gene Tree for FKBP1B (if available)

Paralogs for FKBP1B Gene

Paralogs for FKBP1B Gene

Pseudogenes.org Pseudogenes for FKBP1B Gene

genes like me logo Genes that share paralogs with FKBP1B: view

Variants for FKBP1B Gene

Sequence variations from dbSNP and Humsavar for FKBP1B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs14388 -- 24,063,319(+) GGCAT(C/T)ATCCA utr-variant-3-prime
rs15346 -- 24,063,520(+) ACACA(C/T)ACAAG utr-variant-3-prime
rs1050273 -- 24,063,458(+) CTGAT(A/G)ACAGA utr-variant-3-prime
rs1148946 -- 24,059,727(+) catct(C/T)tacta intron-variant
rs1424344 -- 24,061,096(+) CACCC(C/T)TCTCC intron-variant

Relevant External Links for FKBP1B Gene

HapMap Linkage Disequilibrium report
FKBP1B

No data available for Structural Variations from Database of Genomic Variants (DGV) for FKBP1B Gene

Disorders for FKBP1B Gene

(6) Novoseek inferred disease relationships for FKBP1B Gene

Disease -log(P) Hits PubMed IDs
ventricular tachycardia, catecholaminergic polymorphic 91.6 1
death sudden cardiac 66.4 1
arrhythmia 59.5 3
death sudden 57.3 1
heart failure 56.8 8

Relevant External Links for FKBP1B

Genetic Association Database (GAD)
FKBP1B
Human Genome Epidemiology (HuGE) Navigator
FKBP1B
genes like me logo Genes that share disorders with FKBP1B: view

No data available for UniProtKB/Swiss-Prot for FKBP1B Gene

Publications for FKBP1B Gene

  1. Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts. (PMID: 7513996) Arakawa H. … Nakamura Y. (Biochem. Biophys. Res. Commun. 1994) 2 3 4 23
  2. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. (PMID: 10830164) Marx S.O. … Marks A.R. (Cell 2000) 3 4 23
  3. A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor. (PMID: 7592869) Lam E. … Wiederrecht G.J. (J. Biol. Chem. 1995) 3 4 23
  4. Association of EDNRA, but not WNK4 or FKBP1B, polymorphisms with essential hypertension. (PMID: 14616768) Benjafield A.V. … Morris B.J. (Clin. Genet. 2003) 3 23 49
  5. Genomic organization, chromosomal localization, and promoter of human gene for FK506-binding protein 12.6. (PMID: 16122887) Nakazawa T. … Okamoto H. (Gene 2005) 3 4 23

Products for FKBP1B Gene

Sources for FKBP1B Gene

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