Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FKBP1B Gene

Aliases for FKBP1B Gene

  • FK506 Binding Protein 1B 2 3 5
  • FK506 Binding Protein 1B, 12.6 KDa 2 3
  • 12.6 KDa FK506-Binding Protein 3 4
  • Immunophilin FKBP12.6 3 4
  • 12.6 KDa FKBP 3 4
  • PPIase FKBP1B 3 4
  • Calstabin 2 2 3
  • EC 4 61
  • FKBP-12.6 3 4
  • H-FKBP-12 3 4
  • Rotamase 3 4
  • FKBP12.6 3 4
  • FKBP-1B 3 4
  • FKBP1L 3 4
  • OTK4 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase FKBP1B 3
  • FK506-Binding Protein 1B (12.6 KD) 2
  • FK506-Binding Protein 12.6 3
  • FK506-Binding Protein 1B 4
  • PPIASE 3
  • PKBP1L 3
  • FKBP9 4

External Ids for FKBP1B Gene

Previous HGNC Symbols for FKBP1B Gene

  • FKBP1L

Previous GeneCards Identifiers for FKBP1B Gene

  • GC02P024188
  • GC02P024365
  • GC02P024230
  • GC02P024248
  • GC02P024249
  • GC02P024184
  • GC02P024126
  • GC02P024272

Summaries for FKBP1B Gene

Entrez Gene Summary for FKBP1B Gene

  • The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for FKBP1B Gene

FKBP1B (FK506 Binding Protein 1B) is a Protein Coding gene. Diseases associated with FKBP1B include Catecholaminergic Polymorphic Ventricular Tachycardia and Left Ventricular Noncompaction. Among its related pathways are Ion channel transport and Cardiac conduction. GO annotations related to this gene include receptor binding and peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is MIR6869.

UniProtKB/Swiss-Prot for FKBP1B Gene

  • Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Gene Wiki entry for FKBP1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBP1B Gene

Genomics for FKBP1B Gene

Regulatory Elements for FKBP1B Gene

Enhancers for FKBP1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F024014 1.3 Ensembl ENCODE 8.9 -33.3 -33348 3.8 MLX ZNF133 ZFP64 ARID4B SIN3A ZNF48 SLC30A9 FOS SP5 ZHX2 FAM228B FKBP1B PFN4 MFSD2B RNU6-370P
GH02F023669 1 Ensembl ENCODE 9.5 -379.8 -379800 1.8 PKNOX1 BMI1 ZIC2 GATA3 SCRT2 EED ETV6 CREM SCRT1 MTA2 FKBP1B PFN4 FAM228A GC02P023666 ENSG00000283031
GH02F023916 1 Ensembl ENCODE 8.9 -132.2 -132201 2.2 ZNF384 CEBPG RARA ZNF121 NR2F6 HOMEZ NFE2L2 NR2F1 CEBPB ZBTB8A UBXN2A FKBP1B PFN4 ATAD2B RPS13P4
GH02F024048 0.9 ENCODE 0.8 +0.1 101 1.6 ELF3 KLF17 ARID4B ZNF48 ZNF2 ZNF121 GLIS2 ZNF366 ZNF391 THAP11 FAM228B SF3B6 MFSD2B TP53I3 ATAD2B UBXN2A PFN4 FKBP1B GC02M024079 PIR43014
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FKBP1B on UCSC Golden Path with GeneCards custom track

Promoters for FKBP1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001650715 100 1999 ELF3 KLF17 ARID4B ZNF48 RAD21 ZNF2 RARA ZNF121 GLIS2 ZNF366

Genomic Location for FKBP1B Gene

24,049,701 bp from pter
24,067,743 bp from pter
18,043 bases
Plus strand

Genomic View for FKBP1B Gene

Genes around FKBP1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FKBP1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FKBP1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP1B Gene

Proteins for FKBP1B Gene

  • Protein details for FKBP1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP1B
    Protein Accession:
    Secondary Accessions:
    • Q13664
    • Q16645
    • Q53TM2
    • Q9BQ40

    Protein attributes for FKBP1B Gene

    108 amino acids
    Molecular mass:
    11783 Da
    Quaternary structure:
    • Identified in a complex composed of RYR2, FKBP1B, PKA catalytic subunit, PRKAR2A, AKAP6, and the protein phosphatases PP2A and PP1. Interacts directly with RYR2.

    Three dimensional structures from OCA and Proteopedia for FKBP1B Gene

    Alternative splice isoforms for FKBP1B Gene


neXtProt entry for FKBP1B Gene

Selected DME Specific Peptides for FKBP1B Gene


Post-translational modifications for FKBP1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cloud-Clone Corp. Antibodies for FKBP1B

Domains & Families for FKBP1B Gene

Gene Families for FKBP1B Gene

Protein Domains for FKBP1B Gene

Suggested Antigen Peptide Sequences for FKBP1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PPIase FKBP-type domain.
  • Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
  • Contains 1 PPIase FKBP-type domain.
  • Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
genes like me logo Genes that share domains with FKBP1B: view

Function for FKBP1B Gene

Molecular function for FKBP1B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by both FK506 and rapamycin.
UniProtKB/Swiss-Prot Function:
Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Enzyme Numbers (IUBMB) for FKBP1B Gene

Gene Ontology (GO) - Molecular Function for FKBP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IDA 7592869
GO:0005102 receptor binding IPI 10830164
GO:0005219 contributes_to ryanodine-sensitive calcium-release channel activity TAS 11322937
GO:0005515 protein binding IPI 7592869
GO:0005528 FK506 binding IDA 7592869
genes like me logo Genes that share ontologies with FKBP1B: view
genes like me logo Genes that share phenotypes with FKBP1B: view

Animal Models for FKBP1B Gene

MGI Knock Outs for FKBP1B:

Animal Model Products

miRNA for FKBP1B Gene

miRTarBase miRNAs that target FKBP1B

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FKBP1B Gene

Localization for FKBP1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP1B Gene

Cytoplasm. Sarcoplasmic reticulum.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FKBP1B gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 4
plasma membrane 2

Gene Ontology (GO) - Cellular Components for FKBP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12443530
GO:0005829 cytosol IC 7592869
GO:0016020 membrane IDA 12443530
GO:0016529 sarcoplasmic reticulum IEA --
GO:0030018 Z disc IDA 20431056
genes like me logo Genes that share ontologies with FKBP1B: view

Pathways & Interactions for FKBP1B Gene

genes like me logo Genes that share pathways with FKBP1B: view

Pathways by source for FKBP1B Gene

1 PharmGKB pathway for FKBP1B Gene

Gene Ontology (GO) - Biological Process for FKBP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IDA 7592869
GO:0002027 regulation of heart rate IEA --
GO:0006457 protein folding IEA --
GO:0006458 de novo protein folding TAS 11322937
GO:0006939 smooth muscle contraction IEA --
genes like me logo Genes that share ontologies with FKBP1B: view

No data available for SIGNOR curated interactions for FKBP1B Gene

Drugs & Compounds for FKBP1B Gene

(7) Drugs for FKBP1B Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for FKBP1B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FKBP1B: view

Transcripts for FKBP1B Gene

Unigene Clusters for FKBP1B Gene

FK506 binding protein 1B, 12.6 kDa:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP1B Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h · 6i
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: - - - -

Relevant External Links for FKBP1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FKBP1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FKBP1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FKBP1B Gene

This gene is overexpressed in Fetal Brain (46.4), Frontal cortex (9.0), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FKBP1B Gene

Protein tissue co-expression partners for FKBP1B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FKBP1B Gene:


SOURCE GeneReport for Unigene cluster for FKBP1B Gene:


mRNA Expression by UniProt/SwissProt for FKBP1B Gene:

Tissue specificity: Detected in heart muscle (at protein level). Isoform 1 and isoform 2 are ubiquitous with highest levels in brain and thymus.
genes like me logo Genes that share expression patterns with FKBP1B: view

No data available for mRNA differential expression in normal tissues for FKBP1B Gene

Orthologs for FKBP1B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FKBP1B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FKBP1B 34 35
  • 100 (n)
(Canis familiaris)
Mammalia FKBP1B 34 35
  • 97.22 (n)
(Bos Taurus)
Mammalia FKBP1B 34 35
  • 95.37 (n)
(Mus musculus)
Mammalia Fkbp1b 34 16 35
  • 94.44 (n)
(Monodelphis domestica)
Mammalia FKBP1B 35
  • 94 (a)
(Rattus norvegicus)
Mammalia Fkbp1b 34
  • 93.83 (n)
(Gallus gallus)
Aves FKBP1B 34 35
  • 86.11 (n)
(Anolis carolinensis)
Reptilia FKBP1B 35
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fkbp1b 34
  • 80.56 (n)
Str.15290 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.21934 34
(Danio rerio)
Actinopterygii fkbp1b 34 35
  • 78.4 (n)
zgc73381 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11606 34
fruit fly
(Drosophila melanogaster)
Insecta FK506-bp2 36 35
  • 69 (a)
(Caenorhabditis elegans)
Secernentea fkb-2 35
  • 56 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPR1 35
  • 53 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3865 35
  • 71 (a)
Species where no ortholog for FKBP1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FKBP1B Gene

Gene Tree for FKBP1B (if available)
Gene Tree for FKBP1B (if available)

Paralogs for FKBP1B Gene

Paralogs for FKBP1B Gene Pseudogenes for FKBP1B Gene

genes like me logo Genes that share paralogs with FKBP1B: view

Variants for FKBP1B Gene

Sequence variations from dbSNP and Humsavar for FKBP1B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10153678 -- 24,045,272(+) AAACT(C/G)CTGAA intron-variant
rs10167808 -- 24,049,110(+) CAACG(C/G)TCTGA intron-variant, upstream-variant-2KB
rs10170821 -- 24,037,275(+) gcctc(C/G)gcctc intron-variant
rs10179142 -- 24,032,992(+) GTAAT(C/G)GAGTT intron-variant, upstream-variant-2KB
rs10181898 -- 24,061,736(+) caaaa(C/G)tagat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FKBP1B Gene

Variant ID Type Subtype PubMed ID
nsv997445 CNV gain 25217958
nsv997725 CNV gain 25217958

Variation tolerance for FKBP1B Gene

Residual Variation Intolerance Score: 43.8% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FKBP1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FKBP1B Gene

Disorders for FKBP1B Gene

MalaCards: The human disease database

(2) MalaCards diseases for FKBP1B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
catecholaminergic polymorphic ventricular tachycardia
  • catecholamine-induced polymorphic ventricular tachycardia
left ventricular noncompaction
  • left ventricular hypertrabeculation
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FKBP1B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FKBP1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FKBP1B Gene

Publications for FKBP1B Gene

  1. Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts. (PMID: 7513996) Arakawa H. … Nakamura Y. (Biochem. Biophys. Res. Commun. 1994) 2 3 4 22 64
  2. Genomic organization, chromosomal localization, and promoter of human gene for FK506-binding protein 12.6. (PMID: 16122887) Nakazawa T. … Okamoto H. (Gene 2005) 3 4 22 64
  3. Association of EDNRA, but not WNK4 or FKBP1B, polymorphisms with essential hypertension. (PMID: 14616768) Benjafield A.V. … Morris B.J. (Clin. Genet. 2003) 3 22 46 64
  4. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. (PMID: 10830164) Marx S.O. … Marks A.R. (Cell 2000) 3 4 22 64
  5. A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor. (PMID: 7592869) Lam E. … Wiederrecht G.J. (J. Biol. Chem. 1995) 3 4 22 64

Products for FKBP1B Gene

Sources for FKBP1B Gene

Loading form....