Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FKBP1A Gene

protein-coding   GIFtS: 70
GCID: GC20M001349

FK506 Binding Protein 1A, 12kDa

(Previous name: FK506-binding protein 1A (12kD))
(Previous symbol: FKBP1)
  Search for FKBP1A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
FK506 Binding Protein 1A, 12kDa1 2     PKCI22
FKBP11 2 3     PPIASE2
FKBP122 3 5     calstabin-12
FK506-Binding Protein 1A (12kD)1 2     FK506 Binding Protein122
Calstabin 11 2     FK506-Binding Protein 12
Immunophilin FKBP122 3     FK506-Binding Protein 122
12 KDa FK506-Binding Protein2 3     FK506-Binding Protein, T-Cell, 12-KD2
12 KDa FKBP2 3     Peptidyl-Prolyl Cis-Trans Isomerase FKBP1A2
FKBP-122 3     Protein Kinase C Inhibitor 22
FKBP-1A2 3     rotamase2
PPIase FKBP1A2 3     Calstabin-13
EC 5.2.1.83 8     Rotamase3
FKBP12-Exip32     FK506-Binding Protein 1A3
PKC122     

External Ids:    HGNC: 37111   Entrez Gene: 22802   Ensembl: ENSG000000888327   OMIM: 1869455   UniProtKB: P629423   

Export aliases for FKBP1A gene to outside databases

Previous GC identifers: GC20M001337 GC20M001344 GC20M001297


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FKBP1A Gene:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in
immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a
cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several
intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple
intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric
skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder
known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same
protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of
which is transcribed. (provided by RefSeq, Sep 2008)

GeneCards Summary for FKBP1A Gene:
FKBP1A (FK506 binding protein 1A, 12kDa) is a protein-coding gene. GO annotations related to this gene include SMAD binding and signal transducer activity. An important paralog of this gene is FKBP5.

UniProtKB/Swiss-Prot: FKB1A_HUMAN, P62942
Function: Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor,
preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the
association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May
modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the
cis-trans isomerization of proline imidic peptide bonds in oligopeptides

summary for FKBP1A Gene:
Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from
serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the
actions of kinases and phosphorylases and therefore play an integral role in many signal transduction
pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1,
calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a
divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the
phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This
makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr
phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are
subtype-specific.

Gene Wiki entry for FKBP1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011387.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the FKBP1A gene promoter:
         RFX1   Sp1   MEF-2   p300   E47   MEF-2A   POU2F1   POU2F1a   HSF2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFKBP1A promoter sequence
   Search Chromatin IP Primers for FKBP1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FKBP1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

FKBP1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FKBP1A gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M001349:  view genomic region     (about GC identifiers)

Start:
1,349,621 bp from pter      End:
1,373,816 bp from pter
Size:
24,196 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FKB1A_HUMAN, P62942 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase FKBP1A  
Size: 108 amino acids; 11951 Da
Subunit: Interacts directly with RYR1, RYR2 and RYR3. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A
and protein phosphatase 1 (PP1) (By similarity). Interacts with TGFBR1; prevents TGFBR1 phosphorylation by TGFBR2
and stabilizes it in the inactive conformation. Interacts with ACVR1B and SMAD7
Selected PDB 3D structures from and Proteopedia for FKBP1A (see all 42):
1A7X (3D)        1B6C (3D)        1BKF (3D)        1BL4 (3D)        1D6O (3D)        1D7H (3D)    
Secondary accessions: D3DVW6 P20071 Q4VC47 Q6FGD9 Q6LEU3 Q9H103 Q9H566

Explore the universe of human proteins at neXtProt for FKBP1A: NX_P62942

Explore proteomics data for FKBP1A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys48, Lys53
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for FKBP1A (P62942) (see all 5)
     GKKFDSS  KFDSSRDR  GDGRTFPK  AYGATGHPG 


    See FKBP1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_000792.1  NP_001186715.1  NP_463460.1  

    ENSEMBL proteins: 
     ENSP00000383003   ENSP00000371143   ENSP00000371138   ENSP00000371134   ENSP00000409863  
    Reactome Protein details: P62942

    FKBP1A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for FKBP1A (FKBP12)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for FKBP1A
    OriGene Protein Over-expression Lysate for FKBP1A
    OriGene MassSpec for FKBP1A
    OriGene Custom Protein Services for FKBP1A
    GenScript Custom Purified and Recombinant Proteins Services for FKBP1A
    Novus Biologicals FKBP1A Proteins
    Novus Biologicals FKBP1A Lysates
    Sino Biological Recombinant Protein for FKBP1A
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for FKBP1A
    Cloud-Clone Corp. Proteins for FKBP1A

     
    Search eBioscience for Proteins for FKBP1A 

    FKBP1A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for FKBP1A (FKBP12)
    OriGene Antibodies for FKBP1A
    OriGene Custom Antibody Services for FKBP1A
    Novus Biologicals FKBP1A Antibodies
    Abcam antibodies for FKBP1A
    Cloud-Clone Corp. Antibodies for FKBP1A
    ThermoFisher Antibody for FKBP1A
    LSBio Antibodies in human, mouse, rat for FKBP1A

    FKBP1A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FKBP1A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FKBP1A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FKBP1A
    Cloud-Clone Corp. CLIAs for FKBP1A
    Search eBioscience for ELISAs for FKBP1A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR023566 PPIase_FKBP
     IPR001179 PPIase_FKBP_dom

    Graphical View of Domain Structure for InterPro Entry P62942

    ProtoNet protein and cluster: P62942

    UniProtKB/Swiss-Prot: FKB1A_HUMAN, P62942
    Similarity: Belongs to the FKBP-type PPIase family. FKBP1 subfamily
    Similarity: Contains 1 PPIase FKBP-type domain


    Find genes that share domains with FKBP1A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FKB1A_HUMAN, P62942
    Function: Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor,
    preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the
    association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May
    modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the
    cis-trans isomerization of proline imidic peptide bonds in oligopeptides
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)
    Enzyme regulation: Inhibited by both FK506 and rapamycin

         Genatlas biochemistry entry for FKBP1A:
    FK506-binding protein 1A,T cell binding protein FKBP-12 for the immunosuppressive agents FK506-rapamycin ,with
    intrinsic peptidyl-prolyl cis-trans isomerase activity

         Enzyme Number (IUBMB): EC 5.2.1.81 2

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity TAS11322937
    GO:0004871signal transducer activity IMP12761501
    GO:0005024contributes to transforming growth factor beta-activated receptor activity TAS11322937
    GO:0005160transforming growth factor beta receptor binding ISS7518616
    GO:0005219contributes to ryanodine-sensitive calcium-release channel activity TAS11322937
         
    Find genes that share ontologies with FKBP1A           About GenesLikeMe


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Fkbp1a):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size/body 
     homeostasis/metabolism  integument  liver/biliary system  mortality/aging  muscle 
     nervous system  normal  respiratory system 

    Find genes that share phenotypes with FKBP1A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fkbp1atm1Zuk for FKBP1A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FKBP1A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FKBP1A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FKBP1A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FKBP1A

    miRNA
    Products:
        
    miRTarBase miRNAs that target FKBP1A:
    hsa-mir-92a-3p (MIRT049043), hsa-mir-320a (MIRT044667), hsa-mir-103a-3p (MIRT027184), hsa-mir-218-5p (MIRT046994), hsa-mir-505-5p (MIRT037938), hsa-mir-375 (MIRT019913)

    Block miRNA regulation of human, mouse, rat FKBP1A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FKBP1A (see all 50):
    hsa-miR-26a-2* hsa-miR-15a hsa-miR-25 hsa-miR-424 hsa-miR-3613-3p hsa-miR-34b hsa-miR-497* hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidFKBP1A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FKBP1A
    Predesigned siRNA for gene silencing in human, mouse, rat FKBP1A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FKBP1A

    Clone
    Products:
         
    OriGene clones in human, mouse for FKBP1A (see all 11)
    OriGene ORF clones in mouse, rat for FKBP1A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): FKBP1A (NM_000801)
    Sino Biological Human cDNA Clone for FKBP1A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FKBP1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FKBP1A
    Addgene plasmids for FKBP1A 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FKBP1A
    Browse ESI BIO Cell Lines and PureStem Progenitors for FKBP1A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBP1A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FKB1A_HUMAN, P62942: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    endoplasmic reticulum4
    nucleus2
    plasma membrane2
    cytoskeleton1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA12443530
    GO:0005829cytosol TAS--
    GO:0014802terminal cisterna ISS1374404
    GO:0016020membrane IDA12443530
    GO:0030018Z disc IDA--

    Find genes that share ontologies with FKBP1A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FKBP1A About   (see all 21)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Loss of Function of SMAD2/3 in Cancer
    Loss of Function of SMAD2/3 in Cancer0.60
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    TGFBR2 MSI Frameshift Mutants in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    Signaling by TGF-beta Receptor Complex in Cancer0.60
    SMAD4 MH2 Domain Mutants in Cancer0.60
    2ALK1 signaling events
    ALK1 signaling events
    ALK1 pathway0.00
    3TGF-beta receptor signaling activates SMADs
    TGF-beta receptor signaling activates SMADs0.82
    4Signaling by GPCR
    Signal Transduction0.58
    5p70S6K Signaling
    mTOR Pathway0.54


    Find genes that share SuperPaths with FKBP1A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for FKBP1A
        mTOR Pathway

    3 GeneGo (Thomson Reuters) Pathways for FKBP1A
        Signal transduction Activin A signaling regulation
    Development TGF-beta receptor signaling
    Signal transduction Calcium signaling

    Selected BioSystems Pathways for FKBP1A (see all 13)
        TGF Beta Signaling Pathway
    TOR signaling
    Calcium Regulation in the Cardiac Cell
    Spinal Cord Injury
    TGF-beta Receptor Signaling Pathway


    5 Reactome Pathways for FKBP1A
        TGF-beta receptor signaling activates SMADs
    TGFBR1 LBD Mutants in Cancer
    TGFBR1 KD Mutants in Cancer
    TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
    TGFBR2 Kinase Domain Mutants in Cancer

    1 PharmGKB Pathway for FKBP1A
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FKBP1A: 
              mTOR Signaling in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FKBP1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FKBP1A (P629421, 2, 3 ENSP000003711384) via UniProtKB, MINT, STRING, and/or I2D (see all 226)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000413protein peptidyl-prolyl isomerization TAS11322937
    GO:0003007heart morphogenesis ISS--
    GO:0006457protein folding NAS1930186
    GO:0006458'de novo' protein folding TAS11322937
    GO:0007179transforming growth factor beta receptor signaling pathway TAS--

    Find genes that share ontologies with FKBP1A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for FKBP1A
      Browse compounds at ApexBio 

    Compounds for FKBP1A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SalubrinalSelective inhibitor of eIF2alpha dephosphorylation[405060-95-9]
    FK 506Potent calcineurin inhibitor; immunosuppressant[104987-11-3]
    Cyclosporin ACalcineurin inhibitor[59865-13-3]
    Okadaic acidProtein phosphatase 1 and 2A inhibitor[78111-17-8]
    Calyculin AProtein phosphatase 1 and 2A inhibitor[101932-71-2]

    1 HMDB Compound for FKBP1A    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected DrugBank Compounds for FKBP1A (see all 15)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    4-Hydroxy-2-Butanone-- --target--17139284 17016423 10592235
    FKB-001-- --target--17139284 17016423 10592235
    L-709,587-- --target--17139284 17016423 10592235
    Methyl Methylsulfinylmethyl Sulfide-- 33577-16-1target--17139284 17016423 10592235
    {3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic Acid-- --target--17139284 17016423 10592235
    Sirolimus(-)-Rapamycin (see all 2)53123-88-9targetother11752352 12742462
    TacrolimusFK-506 (see all 3)104987-11-3targetinhibitor16289353 17524933
    (21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE-- --target--10592235
    (3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Leucine-- --target--10592235
    (3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Phenylalanine Ethyl Ester-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for FKBP1A gene (see all 30)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tacrolimus 92.1 344 8545894 (5), 1379588 (5), 16246307 (4), 8563622 (4) (see all 99)
    rapamycin 89.3 209 10998178 (4), 10330150 (4), 11335722 (4), 8325502 (3) (see all 96)
    ryanodine 81.5 61 8599646 (4), 9743407 (4), 9461216 (4), 9502200 (3) (see all 36)
    ascomycin 75.4 3 10543889 (2), 9383417 (1)
    everolimus 61.4 1 16278292 (1)
    cyclosporin a 57.6 7 8794888 (1), 11982754 (1), 14523907 (1), 10412950 (1) (see all 6)
    caffeine 44.1 7 17950843 (2), 7527548 (1), 7514503 (1)
    calcium 44 70 7527548 (5), 16278292 (5), 8521476 (3), 7533300 (3) (see all 38)
    inositol 1,4,5 trisphosphate 43.7 6 9346894 (2), 9660798 (1), 9742506 (1), 11557049 (1) (see all 5)
    dihydropyridine 35.6 5 15269663 (1), 15998242 (1), 11751303 (1), 16621918 (1)

    1 PharmGKB related drug/compound annotation for FKBP1A gene    About this table
    Drug/compound PharmGKB Annotation
    everolimus



    Find genes that share compounds with FKBP1A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FKBP1A gene (3 alternative transcripts): 
    NM_000801.4  NM_001199786.1  NM_054014.3  

    Unigene Cluster for FKBP1A:

    FK506 binding protein 1A, 12kDa
    Hs.471933  [show with all ESTs]
    Unigene Representative Sequence: NM_000801
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000474657 ENST00000400137(uc010gac.2 uc002wey.3 uc002wez.3 uc010gaf.2 uc010gae.2)
    ENST00000381724 ENST00000460490 ENST00000474726 ENST00000381719(uc002wfb.3 uc002wfa.3)
    ENST00000381715 ENST00000439640
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FKBP1A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FKBP1A (see all 50):
    hsa-miR-26a-2* hsa-miR-15a hsa-miR-25 hsa-miR-424 hsa-miR-3613-3p hsa-miR-34b hsa-miR-497* hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidFKBP1A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FKBP1A
    Predesigned siRNA for gene silencing in human, mouse, rat FKBP1A
    Clone
    Products:
         
    OriGene clones in human, mouse for FKBP1A (see all 11)
    OriGene ORF clones in mouse, rat for FKBP1A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): FKBP1A (NM_000801)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FKBP1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FKBP1A
    Addgene plasmids for FKBP1A 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FKBP1A
    OriGene qSTAR qPCR primer pairs in human, mouse for FKBP1A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FKBP1A
      QuantiTect SYBR Green Assays in human, mouse, rat FKBP1A
      QuantiFast Probe-based Assays in human, mouse, rat FKBP1A

    Additional mRNA sequence: 

    AB241123.1 AB241124.1 AK309026.1 BC001925.1 BC005147.2 BC119732.1 BT007066.1 CR407613.1 
    CR542168.1 M34539.1 X52220.1 

    Selected DOTS entries (see all 35):

    DT.100870942  DT.100847570  DT.100854207  DT.87077786  DT.120799367  DT.100655249  DT.120799438  DT.100732414 
    DT.100869037  DT.92459538  DT.100732306  DT.100655253  DT.92459549  DT.95094918  DT.92459542  DT.95346255 
    DT.100849331  DT.120799348  DT.120799444  DT.95077610  DT.120799341  DT.92459526  DT.97848563  DT.100040794 

    Selected AceView cDNA sequences (see all 1172):

    CR600891 AI076813 BQ029433 CR602858 BQ669110 CR600975 BM843537 CR610147 
    BM786532 BF061428 BU625567 AW069878 BQ877306 BU527275 CR595798 CR602019 
    BM662783 BM705516 AV709154 CR599015 BX339352 AA302287 W47374 BM791768 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FKBP1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAAATCCTT
    FKBP1A Expression
    About this image


    FKBP1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Negative 2 Thymocytes Thymus
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
    FKBP1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FKBP1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.471933
        Pathway & Disease-focused RT2 Profiler PCR Arrays including FKBP1A: 
              mTOR Signaling in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FKBP1A
    OriGene qSTAR qPCR primer pairs in human, mouse for FKBP1A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FKBP1A
    QuantiTect SYBR Green Assays in human, mouse, rat FKBP1A
    QuantiFast Probe-based Assays in human, mouse, rat FKBP1A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBP1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FKBP1A gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fkbp1a1 , 5 FK506 binding protein 1a1, 5 93.21(n)1
    97.22(a)1
      2 (74.83 cM)5
    142251  NM_008019.21  NP_032045.11 
     1515424835 
    chicken
    (Gallus gallus)
    Aves FKBP1A1 FK506 binding protein 1A, 12kDa 83.64(n)
    91.67(a)
      374233  NM_204330.1  NP_989661.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Peptidyl-prolyl cis-trans isomerase
    89(a)
    1 → many
    GL343346.1(874566-875912)
    zebrafish
    (Danio rerio)
    Actinopterygii fkbp1ab1 FK506 binding protein 1Ab 72.22(n)
    82.41(a)
      449552  NM_001005594.1  NP_001005594.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta FK506-bp23 protein folding FK506 binding 75(a)   56C8   --
    worm
    (Caenorhabditis elegans)
    Secernentea fkb-23 FKBP-type peptidyl-prolyl cis-trans
    isomerases
    60(a)   I(12926778-12927157)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FPR1(YNL135C)4 Peptidyl-prolyl cis-trans isomerase (PPIase), binds more   --   14(372226-371882) 855587  NP_014264.1 


    ENSEMBL Gene Tree for FKBP1A (if available)
    TreeFam Gene Tree for FKBP1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FKBP1A gene
    FKBP52  FKBP1C2  FKBP42  FKBP82  FKBP62  FKBP1B2  FKBP32  
    16 SIMAP similar genes for FKBP1A using alignment to 4 protein entries:     FKB1A_HUMAN (see all proteins):
    FKBP12-Exip3    FKBP12-Exin    FKBP1C    FKBP1B    FKBP12-Exip2    FKBP4
    FKBP6    FKBP5    FKBP2    FKBP7    FKBP14    FKBP9
    FKBP10    DKFZp666D193    FKBP11    FKBP8

    Find genes that share paralogs with FKBP1A           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for FKBP1A
    PGOHUM00000248586 PGOHUM00000246846 PGOHUM00000250590 PGOHUM00000250264


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus
    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FKBP1A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv522008CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FKBP1A
    DNA2.0 Custom Variant and Variant Library Synthesis for FKBP1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 186945    OMIM disorders: --

    4 diseases from the University of Copenhagen DISEASES database for FKBP1A:
    Fibrodysplasia ossificans progressiva     Polyneuropathy     Malignant hyperthermia     Familial adenomatous polyposis

    Find genes that share disorders with FKBP1A           About GenesLikeMe

    Selected Novoseek inferred disease relationships for FKBP1A gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ataxia telangiectasia 30.7 2 10325225 (1), 9465032 (1)
    neurodegenerative diseases 7.98 2 12871169 (1), 17011518 (1)
    carcinoma 3.78 1 12599018 (1)
    breast cancer 2.95 1 10412950 (1)
    restenosis 2.94 1 17962721 (1)
    tumors 2.48 2 9154824 (1), 14612567 (1)
    autoimmune diseases 0 3 10433096 (2)
    neurological disorders 0 1 15732051 (1)
    shock 0 3 11245643 (1), 18177671 (1)
    neurodegeneration 0 2 12526984 (1), 16036432 (1)

    Genetic Association Database (GAD): FKBP1A
    Human Genome Epidemiology (HuGE) Navigator: FKBP1A (5 documents)

    Export disorders for FKBP1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FKBP1A gene, integrated from 10 sources (see all 349):
    (articles sorted by number of sources associating them with FKBP1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor. (PubMed id 16720724)1, 2, 9 Yamaguchi T.... Sugino H. (J. Mol. Endocrinol. 2006)
    2. Exon organization of the human FKBP-12 gene: correlation with structural and functional protein domains. (PubMed id 1716149)1, 2, 9 Dilella A.G. and Craig R.J. (Biochemistry 1991)
    3. Three distinct messenger RNAs can encode the human immunosuppressant- binding protein FKBP12. (PubMed id 7529739)1, 2, 9 Peattie D.A.... Lippke J.A. (Gene 1994)
    4. Solution structure of FK506 bound to FKBP-12. (PubMed id 1375171)1, 2, 9 Lepre C.A.... Moore J.M. (FEBS Lett. 1992)
    5. Chromosomal assignment of the human immunophilin FKBP-12 gene. (PubMed id 1930186)1, 3, 9 DiLella A.G. (Biochem. Biophys. Res. Commun. 1991)
    6. Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels. (PubMed id 22100703)1, 2 Wen H.... Park S. (Arch. Biochem. Biophys. 2012)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    10. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2280 HGNC: 3711 AceView: FKBP1AandSDCBP2 Ensembl:ENSG00000088832 euGenes: HUgn2280
    ECgene: FKBP1A H-InvDB: FKBP1A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FKBP1A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FKBP1A gene:
    Search GeneIP for patents involving FKBP1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for FKBP1A (FKBP12)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for FKBP1A (FKBP12)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for FKBP1A   OriGene RNAi products in human, mouse, rat for FKBP1A  
     OriGene qPCR primer pairs and template standards for FKBP1A   OriGene Protein Over-expression Lysate for FKBP1A  
     OriGene MassSpec something-or-other for FKBP1A   OriGene clones in human, mouse for FKBP1A  
     OriGene qSTAR qPCR primer pairs in human, mouse for FKBP1A   OriGene Purified Protein for FKBP1A  
     OriGene ORF clones in mouse, rat for FKBP1A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FKBP1A   OriGene Custom Protein Services for FKBP1A  

     
     
     Block miRNA regulation of human, mouse, rat FKBP1A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FKBP1A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FKBP1A Predesigned siRNA for gene silencing in human, mouse, rat FKBP1A
     QuantiFast Probe-based Assays in human, mouse, rat FKBP1A QuantiTect SYBR Green Assays in human, mouse, rat FKBP1A
     PCR Arrays including human, mouse, rat FKBP1A Search Chromatin IP Primers for FKBP1A
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FKBP1A  GeneGlobe Interaction Network for FKBP1A
     Regulatory tfbs in FKBP1A promoter
     GenScript Custom Purified and Recombinant Proteins Services for FKBP1A GenScript cDNA clones with any tag delivered in your preferred vector for FKBP1A
     GenScript Custom Assay Services for FKBP1A GenScript Custom overexpressing Cell Line Services for FKBP1A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for FKBP1A
     Proteins for FKBP1A
     Browse Sino Biological Cell Lysates
     cDNA Clones for FKBP1A
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs for FKBP1A
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FKBP1A antibodies
     FKBP1A proteins
     FKBP1A lysates
     Antibodies for FKBP1A
     See all of Abcam's Antibodies, Kits and Proteins for FKBP1A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for FKBP1A
     Proteins for FKBP1A
     Antibodies for FKBP1A
     ELISAs for FKBP1A
     CLIAs for FKBP1A



     Browse ESI BIO Cell Lines and PureStem Progenitors for FKBP1A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBP1A
     SwitchGear 3'UTR luciferase reporter plasmids for FKBP1A
     SwitchGear Promoter luciferase reporter plasmids for FKBP1A
     ThermoFisher Antibody for FKBP1A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FKBP1A
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FKBP1A
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FKBP1A
     LSBio Antibodies in human, mouse, rat for FKBP1A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for FKBP1A
      Search eBioscience for proteins for FKBP1A
      Search eBioscience for elisas for FKBP1A
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FKBP1A gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4