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FKBP1A Gene

protein-coding GIFtS: 62

GC20M001297

FK506 binding protein 1A, 12kDa
(Previous name: FK506-binding protein 1A (12kD) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: FKBP1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 5.2.1.8 ^³
FKBP-12 ^¹, ², ³
FKBP-1A ^³
FKBP1 ^², ³
FKBP12 ^¹, ², ³, ⁵
FKBP12C ^¹, ²
OTTHUMP00000029978 ^²
PKC12 ^¹, ²
PKCI2 ^²
PPIASE ^¹, ²
Rotamase ^³
rotamase ^²

Descriptions
12 kDa FKBP ^³
FK506 binding protein 1A, 12kDa ^²
FK506-binding protein 1 ^²
FK506-binding protein 12 ^²
FK506-binding protein 1A ^³
FK506-binding protein 1A (12kD) ^¹, ²
FK506-binding protein, T-cell, 12-kD ^²
Immunophilin FKBP12 ^², ³
PPIase FKBP1A ^³
peptidyl-prolyl cis-trans isomerase ^²
protein kinase C inhibitor 2 ^²

External Ids
HGNC: 3711¹
Entrez Gene: 2280²
UniProtKB: P62942³
Ensembl: ENSG00000088832⁷

Search outside databases for aliases for FKBP1A gene

Previous GC identifers: GC20M001337 GC20M001344

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FKBP1A:

The protein encoded by this gene is a member of the immunophilin protein family, which play a role

in immunoregulation and basic cellular processes involving protein folding and trafficking. The

protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It

interacts with several intracellular signal transduction proteins including type I TGF-beta

receptor. It also interacts with multiple intracellular calcium release channels, and coordinates

multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse,

deletion of this homologous gene causes congenital heart disorder known as noncompaction of left

ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have

been identified. The human genome contains five pseudogenes related to this gene, at least one of

which is transcribed. [provided by RefSeq]

UniProtKB/Swiss-Prot: FKB1A_HUMAN, P62942

Function: May play a role in modulation of ryanodine receptor isoform-1 (RYR-1), a component of the

calcium release channel of skeletal muscle sarcoplasmic reticulum. There are four molecules of

FKBP12 per skeletal muscle RYR. PPIases accelerate the folding of proteins. It catalyzes the

cis-trans isomerization of proline imidic peptide bonds in oligopeptides

Gene Wiki entry for FKBP1A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FKBP1A gene

Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13

FKBP1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M001297: (about GC identifiers)

Start:	1,297,622 bp from pter
End:	1,321,753 bp from pter
Size:	24,132 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000020.9 NT_011387.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: FKB1A_HUMAN, P62942 (See protein sequence)

Recommended Name: Peptidyl-prolyl cis-trans isomerase FKBP1A

Size: 108 amino acids; 11951 Da

Subcellular location: Cytoplasm

PDB structures from and Proteopedia :

1A7X (3D)

1B6C (3D)

1BKF (3D)

1BL4 (3D)

1D6O (3D)

1D7H (3D)

1D7I (3D)

1D7J (3D)

1EYM (3D)

1F40 (3D)

1FAP (3D)

1FKB (3D)

1FKD (3D)

1FKF (3D)

1FKG (3D)

1FKH (3D)

1FKI (3D)

1FKJ (3D)

1FKR (3D)

1FKS (3D)

1FKT (3D)

1J4H (3D)

1J4I (3D)

1J4R (3D)

1NSG (3D)

1QPF (3D)

1QPL (3D)

1TCO (3D)

2DG3 (3D)

2DG4 (3D)

2DG9 (3D)

2FAP (3D)

2FKE (3D)

2PPN (3D)

2PPO (3D)

2PPP (3D)

3FAP (3D)

4FAP (3D)

Secondary accessions: P20071 Q4VC47 Q6FGD9 Q6LEU3 Q9H103 Q9H566

REFSEQ proteins (2 alternative transcripts):

NP_000792.1 NP_463460.1

ENSEMBL proteins:

ENSP00000371134 ENSP00000371143 ENSP00000371138 ENSP00000383003 ENSP00000371161

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for FKBP1A
	R&D Systems Recombinant & Natural Proteins for FKBP1A (FKBP12)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (FKBP12)
	Human Recombinant Proteins from Abnova (FKBP1A)

OriGene Purified Recombinant Human Proteins (see all 2): FKBP1A

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005829	cytosol	IDA	1701173
GO:0014802	terminal cisterna	ISS	1374404

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Antibodies for FKBP1A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for FKBP1A
	R&D Systems Antibodies for FKBP1A (FKBP12)
	Antibodies from Abcam (FKBP12), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for FKBP1A

Assays for FKBP1A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P62942

ProtoNet protein and cluster: P62942

UniProtKB/Swiss-Prot: FKB1A_HUMAN, P62942

Similarity: Belongs to the FKBP-type PPIase family. FKBP1 subfamily

Similarity: Contains 1 PPIase FKBP-type domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FKBP1A)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_054014

Applied Biosystems Silencer® siRNAs for FKBP1A

Sigma-Aldrich siRNA and siRNA Panels for FKBP1A

Sigma-Aldrich shRNA for FKBP1A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FKBP1A
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000801
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000801
untagged cDNA clones in CMV expression vector (see all 2): NM_000801

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_054014

UniProtKB/Swiss-Prot: FKB1A_HUMAN, P62942

Function: May play a role in modulation of ryanodine receptor isoform-1 (RYR-1), a component of the

calcium release channel of skeletal muscle sarcoplasmic reticulum. There are four molecules of

FKBP12 per skeletal muscle RYR. PPIases accelerate the folding of proteins. It catalyzes the

cis-trans isomerization of proline imidic peptide bonds in oligopeptides

Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)

Enzyme regulation: Inhibited by both FK506 and rapamycin

Enzyme Number (IUBMB): EC 5.2.1.8

Genatlas biochemistry entry for FKBP1A:

FK506-binding protein 1A,T cell binding protein FKBP-12 for the immunosuppressive agents

FK506-rapamycin ,with intrinsic peptidyl-prolyl cis-trans isomerase activity

12 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Fkbp1a):

	growth/size	hematopoietic system	homeostasis/metabolism	immune system
lethality-prenatal/perinatal	life span-post-weaning/aging	liver/biliary system	muscle	nervous system
respiratory system	skin/coat/nails

5/9 Gene Ontology (GO) molecular function terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	IEA	--
GO:0004871	signal transducer activity	IMP	12761501
GO:0005024	contributes to transforming growth factor beta receptor activity	TAS	11322937
GO:0005219	contributes to ryanodine-sensitive calcium-release channel activity	TAS	11322937
GO:0005528	FK506 binding	NAS	17962721

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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for FKBP1A

5/59 Interacting proteins for FKBP1A (ENSP00000371138³ P62942^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 59 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FRAP1	P42345¹	EBI-1027571, EBI-359260
RYR1	ENSP00000352608³	STRING (score=.999)
TGFBR1	ENSP00000364133³	STRING (score=.999)
KIAA1303	ENSP00000307272³	STRING (score=.998)
ITPR1	ENSP00000349029³	STRING (score=.992)

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5/16 Gene Ontology (GO) biological process terms (links to tree view) (see all 16 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006458	'de novo' protein folding	TAS	11322937
GO:0007183	SMAD protein complex assembly	IDA	16720724
GO:0022417	protein maturation via protein folding	TAS	11322937
GO:0031398	positive regulation of protein ubiquitination	IDA	16720724
GO:0032092	positive regulation of protein binding	IDA	18346205

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for FKBP1A

Sigma-Aldrich Small Molecules for FKBP1A:

Inhibitor

Browse Tocris compounds for FKBP1A
10/16 Novoseek chemical compound relationships for FKBP1A gene (see all 16 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ryanodine	82.00	61	8599646 (4), 9743407 (4), 9461216 (4), 9502200 (3) (see all 36)
inositol 1,4,5 trisphosphate	44.20	6	9346894 (2), 9660798 (1), 9742506 (1), 11557049 (1) (see all 5)
calcium	43.63	70	7527548 (5), 16278292 (5), 8521476 (3), 7533300 (3) (see all 38)
phosphatidylinositol	27.67	2	17950843 (1), 9465032 (1)
hydrogen	23.08	7	7510408 (2), 15937899 (1), 11014594 (1), 10909868 (1)
threonine	18.80	3	10490847 (1), 16329102 (1), 14766396 (1)
steroid	16.63	4	1371107 (1), 11060810 (1), 12871168 (1)
amide	11.71	1	10909868 (1)
tyrosine	4.21	3	9545268 (3)
ruthenium	3.32	1	16176935 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FKBP1A)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_054014

Sigma-Aldrich siRNA and siRNA Panels for FKBP1A

Sigma-Aldrich shRNA for FKBP1A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000801 NM_054014

REFSEQ mRNAs for FKBP1A gene (2 alternative transcripts):

NM_000801.3 NM_054014.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000801 NM_054014

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000801
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000801
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000801

Additional cDNA sequence:

AB241123.1 AB241124.1 BC001925.1 BC005147.2 BC119732.1 BC119733.1 BT007066.1 CR407613.1

CR542168.1 CR591667.1 CR592860.1 CR593538.1 CR595798.1 CR596571.1 CR597073.1 CR598590.1

CR599015.1 CR599932.1 CR600891.1 CR600975.1 CR602019.1 CR602858.1 CR603630.1 CR609261.1

CR609321.1 CR610147.1 CR610528.1 CR612762.1 CR617035.1 CR617939.1 CR618348.1 CR619636.1

M34539.1 X52220.1

24/37 DOTS entries (see all 37 ):

DT.100870942 DT.100847570 DT.100854207 DT.87077786 DT.120799367 DT.100732414 DT.100655249 DT.120799438

DT.100869037 DT.92459538 DT.100655253 DT.95094918 DT.100732306 DT.92459542 DT.95077610 DT.92459549

DT.120799444 DT.120799348 DT.120799430 DT.95346255 DT.100849331 DT.92459530 DT.120799311 DT.120799341

24/1172 AceView cDNA sequences (see all 1172 ):

BM127052 BM847713 CR600891 H19484 BQ949980 BM981873 CR603630 BM853527

AA302287 BG030660 BM694453 CB131579 CA447388 T94995 CR610147 AA345978

AA031472 CD366653 AV709154 BU153764 CA435302 BU541377 BU622760 BF061428

highest scoring ESTs for FKBP1A:

M34539 AA294971 AA604674 AL515108 AL536822 AL557420 AU118808 AW405588 AW674924 BC001925

Unigene Cluster for FKBP1A:

FK506 binding protein 1A, 12kDa

Hs.471933 [show with all ESTs]

Unigene Representative Sequence: NM_000801

GeneLoc Exon Structure

5 Ensembl transcripts including schematic representations:

ENST00000381715 ENST00000381724 ENST00000381719 ENST00000400137 ENST00000381742

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FKBP1A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FKBP1A

¹ / ² / ³

11 probe-sets matching FKBP1A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
880_at²^{, 3}	U95-A	2	1.00	0.56	0.93	1.40	M34539	1.00	0.80	0.91	1
953_g_at²^{, 3}	U95-A	3	1.00	0.46	0.80	1.06	HG1139-HT4910	0.20	0.50	0.38	1
952_at²^{, 3}	U95-A	1	0.94	1.00	0.93	0.56	HG1139-HT4910	0.20	0.50	0.38	1
210187_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC005147	0.80	0.88	0.84	1
214119_s_at²^{, 3}	U133-A	2	1.00	0.73	--	--	AI936769	0.60	0.83	0.73	1
200709_at²^{, 3}	U133-A	2	1.00	0.59	--	--	NM_000801	0.60	0.83	0.73	1
210186_s_at²^{, 3}	U133-A	3	1.00	0.53	--	--	BC005147	0.80	0.88	0.84	1
210187_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214119_s_at²	U133Plus2	2	1.00	0.73	--	--	--	--	--	--	--
200709_at²	U133Plus2	2	1.00	0.59	--	--	--	--	--	--	--
210186_s_at²	U133Plus2	3	1.00	0.53	--	--	--	--	--	--	--

GeneDecks FKBP1A for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.471933
Expression variation in blood from EXPOLDB for FKBP1A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for FKBP1A gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	FKBP1A¹	--	FK506 binding protein 1A, 12kDa	95.28(n) 99.06(a)	608169 XM_846297.1 XP_851390.1
chimpanzee (Pan troglodytes)	FKBP1A¹	--	FK506 binding protein 1A, 12kDa	100(n) 100(a)	749347 XM_001167897.1 XP_001167897.1
cow (Bos taurus)	FKBP1A¹	--	FK506 binding protein 1A, 12kDa	93.52(n) 94.44(a)	539546 XM_587992.3 XP_587992.2
rat (Rattus norvegicus)	Fkbp1a¹	--	FK506 binding protein 1a	91.98(n) 97.22(a)	25639 XM_001053006.1 XP_001053006.1
mouse (Mus musculus)	Fkbp1a^{1, 5}	2⁵	FK506 binding protein 1a^{1, 5}	93.21(n)¹ 97.22(a)¹	14225¹ NM_008019.2¹ NP_032045.1¹ AB241120⁵ AB241121⁵ (see all 29)

About this table Species with no ortholog for FKBP1A

ENSEMBL Gene Tree for FKBP1A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for FKBP1A gene

FKBP2² FKBP11² FKBP1C² FKBP1B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/182 NCBI SNPs in FKBP1A are shown (see all 182 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 101)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs11712^1,2	A,C,F,O	1298508(-)	`AGTTAT/CTCATT`	1	--	ut3¹		2		MN	372
	rs6041749^1,2	A,C,F,H	1298672(+)	`ATGGAT/CTCATG`	1	--	ut3¹ ese³		12		EU EA WA NA	1054
	rs1998006^1,2	C,F,H,O	1322364(+)	`CCTGCT/CGTCCC`	2	--	ng3¹		7		NA EU EA WA	556
	rs6041759^1,2	C,F,H	1300322(+)	`TTTTTT/CCCCCC`	2	--	int¹ ng5¹ trp³		8		EU EA WA	820
	rs17718574^1,2	C,F,H	1297326(+)	`GTGCTC/GTACCC`	1	--	ng5¹		11		NA EU EA WA	978
--	rs8392^1,2	C,F,H	1298709(-)	`CTGCCA/GTGGAG`	1	--	ut3¹		17		MN EU EA WA NA	1574
--	rs6033645^1,2	A,C	1323577(+)	`aggcaC/Tgagag`	2	--	ng3¹		0	--	--	--	--
	rs7271475^1,2	H	1299902(+)	`TACTAG/CGATAC`	2	--	ng5¹ int¹		4		EU EA WA	420
	rs6105015^1,2	H	1300228(+)	`CCTCCC/TTCATA`	2	--	int¹ ng5¹		4		EU EA WA	416
--	rs1803585^1,2	C	1298123(-)	`CTTTGA/CAAGTA`	1	--	ut3¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for FKBP1A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 186945

10/11 Novoseek disease relationships for FKBP1A gene (see all 11 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ataxia telangiectasia	31.84	2	10325225 (1), 9465032 (1)
neurodegenerative diseases	10.45	2	12871169 (1), 17011518 (1)
restenosis	4.21	1	17962721 (1)
carcinoma	3.62	1	12599018 (1)
breast cancer	2.95	1	10412950 (1)
tumors	2.44	2	9154824 (1), 14612567 (1)
neurological disorders	0.00	1	15732051 (1)
shock	0.00	3	11245643 (1), 18177671 (1)
neurodegeneration	0.00	2	12526984 (1), 16036432 (1)
heart failure	0.00	2	12629052 (1), 11897558 (1)

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1 PharmGKB disease relationship for FKBP1A gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872 12730115

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/234 PubMed articles for FKBP1A gene (see all 234 ):

Exon organization of the human FKBP-12 gene: correlation with structural and functional protein domains. (PubMed id 1716149)^{1, 3, 4} Dilella A.G. and Craig R.J. (1991)
Three distinct messenger RNAs can encode the human immunosuppressant- binding protein FKBP12. (PubMed id 7529739)^{1, 3, 4} Peattie D.A.... Lippke J.A. (1994)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{3, 4} Gevaert K.... Vandekerckhove J. (2003)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{3, 4} Deloukas P....Rogers J. (2001)
X-ray structures of small ligand-FKBP complexes provide an estimate for hydrophobic interaction energies. (PubMed id 10656803)^{3, 4} Burkhard P.... Walkinshaw M.D. (2000)
Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin. (PubMed id 7678431)^{3, 4} van Duyne G.D....Clardy J. (1993)
1H, 13C, and 15N assignments and secondary structure of the FK506 binding protein when bound to ascomycin. (PubMed id 7682113)^{3, 4} Xu R.X....Fesik S.W. (1993)
Solution structure of FK506 bound to FKBP-12. (PubMed id 1375171)^{3, 4} Lepre C.A.... Moore J.M. (1992)
Proton and nitrogen sequential assignments and secondary structure determination of the human FK506 and rapamycin binding protein. (PubMed id 1709363)^{3, 4} Rosen M.K.... Schreiber S.L. (1991)

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Entrez Gene: 2280	HGNC: 3711	AceView: FKBP1AandSDCBP2	Ensembl:ENSG00000088832	euGenes: HUgn2280
ECgene: FKBP1A	H-InvDB: FKBP1A

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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FKBP1A Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for FKBP1A

Summaries
for FKBP1A

Genomic Location
for FKBP1A

Proteins
for FKBP1A

Protein Domains/
Families
for FKBP1A

Gene Function
for FKBP1A

Pathways & Interactions
for FKBP1A

Drugs & Compounds
for FKBP1A

Transcripts
for FKBP1A

Expression
for FKBP1A

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FKBP1A (Gene Symbol)
EC 5.2.1.8
FKBP-12
FKBP-1A
FKBP1
FKBP12
FKBP12C
OTTHUMP00000029978
PKC12
PKCI2
PPIASE
Rotamase
rotamase
12 kDa FKBP
FK506 binding protein 1A, 12kDa
FK506-binding protein 1
FK506-binding protein 12
FK506-binding protein 1A
FK506-binding protein 1A (12kD)
FK506-binding protein, T-cell, 12-kD
Immunophilin FKBP12
PPIase FKBP1A
peptidyl-prolyl cis-trans isomerase
protein kinase C inhibitor 2

FKBP1A Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor FKBP1A

Summariesfor FKBP1A

Genomic Locationfor FKBP1A

Proteinsfor FKBP1A

Protein Domains/Familiesfor FKBP1A

Gene Functionfor FKBP1A

Pathways & Interactionsfor FKBP1A

Drugs & Compoundsfor FKBP1A

Transcriptsfor FKBP1A

Expression for FKBP1A

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Genome Databases showing FKBP1A

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Specialized Databases showing FKBP1A

Licensable Technologiesfor FKBP1A

Servicesfor FKBP1A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FKBP1A

Summaries
for FKBP1A

Genomic Location
for FKBP1A

Proteins
for FKBP1A

Protein Domains/
Families
for FKBP1A

Gene Function
for FKBP1A

Pathways & Interactions
for FKBP1A

Drugs & Compounds
for FKBP1A

Transcripts
for FKBP1A

Expression
for FKBP1A

Orthologs
for FKBP1A

Paralogs
for FKBP1A

SNPs/Variants
for FKBP1A

Disorders & Mutations
for FKBP1A

Medical News
for FKBP1A

Publications
for FKBP1A

Licensable Technologies
for FKBP1A

Services
for FKBP1A