FKBP1A Gene
protein-coding GIFtS: 68
GCID: GC20M001349
|
|
FK506 binding protein 1A, 12kDa(Previous name: FK506-binding protein 1A (12kD) )
(Previous symbol: FKBP1)
| |
Aliases
for FKBP1A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| FK506 Binding Protein 1A, 12kDa1 2 | | FKBP12-Exip32 | | FKBP121 2 3 5 | | PKCI22 | | FKBP-121 2 3 | | Calstabin-13 | | FKBP11 2 3 | | FK506 Binding Protein122 | | PKC121 2 | | FK506-Binding Protein 12 | | PPIASE1 2 | | FK506-Binding Protein 122 | | FK506-Binding Protein 1A (12kD)1 2 | | FK506-Binding Protein, T-Cell, 12-KD2 | | Immunophilin FKBP122 3 | | Peptidyl-Prolyl Cis-Trans Isomerase FKBP1A2 | | 12 KDa FK506-Binding Protein2 3 | | Protein Kinase C Inhibitor 22 | | 12 KDa FKBP2 3 | | Rotamase3 | | FKBP-1A2 3 | | Calstabin-13 | | PPIase FKBP1A2 3 | | Rotamase3 | | EC 5.2.1.83 8 | | FK506-Binding Protein 1A3 | | FKBP12C1 | | |
Export aliases for FKBP1A gene to outside databasesPrevious GC identifers: GC20M001337 GC20M001344 GC20M001297 |
Summaries
for FKBP1A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FKBP1A:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulationand basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerasethat binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transductionproteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels,and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse,deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricularmyocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genomecontains five pseudogenes related to this gene, at least one of which is transcribed. (provided by RefSeq, Sep 2008)
UniProtKB/Swiss-Prot: FKB1A_HUMAN, P62942Function: Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventingTGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calciumchannel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of prolineimidic peptide bonds in oligopeptides
 summary
for FKBP1A: Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from
serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the
actions of kinases and phosphorylases and therefore play an integral role in many signal transduction
pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1,
calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a
divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the
phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This
makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr
phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are
subtype-specific.
Gene Wiki entry for FKBP1A
|
Genomic Views
for FKBP1A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011387.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FKBP1A gene promoter:
RFX1 Sp1 MEF-2 p300 E47 MEF-2A POU2F1 POU2F1a HSF2 aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for FKBP1A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FKBP1A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13FKBP1A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M001349: view genomic region
(about GC identifiers)
Start:
|
1,349,622 bp from pter |
End:
|
1,373,816 bp from pter |
Size:
|
24,195 bases |
Orientation:
|
minus strand |
|
Proteins
for FKBP1A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FKB1A_HUMAN, P62942 (See
protein sequence)Recommended Name: Peptidyl-prolyl cis-trans isomerase FKBP1A Size: 108 amino acids; 11951 Da
Subunit: Interacts directly with RYR1, RYR2 and RYR3. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A andprotein phosphatase 1 (PP1) (By similarity). Interacts with TGFBR1; prevents TGFBR1 phosphorylation by TGFBR2 andstabilizes it in the inactive conformation. Interacts with ACVR1B and SMAD7
Subcellular location: Cytoplasm
6/41 PDB 3D structures from  and Proteopedia  for FKBP1A (see all 41):1A7X (3D)
1B6C (3D)
1BKF (3D)
1BL4 (3D)
1D6O (3D)
1D7H (3D)
Secondary accessions: D3DVW6 P20071 Q4VC47 Q6FGD9 Q6LEU3 Q9H103 Q9H566Explore the universe of human proteins at neXtProt for FKBP1A: NX_P62942
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P62942
4/5 DME Specific Peptides for FKBP1A (P62942) (see all 5)
FKBP1A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_000792.1 NP_001186715.1 NP_463460.1
ENSEMBL proteins: ENSP00000383003 ENSP00000371143 ENSP00000371138 ENSP00000371134 ENSP00000409863 Reactome Protein details: P62942
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
FKBP1A for ontologies About GeneDecksing
FKBP1A Antibody Products:
Assay Products for FKBP1A: |
Protein
Domains /
Families
for FKBP1A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FKBP1A for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P62942ProtoNet protein and cluster: P62942 UniProtKB/Swiss-Prot: FKB1A_HUMAN, P62942Similarity: Belongs to the FKBP-type PPIase family. FKBP1 subfamilySimilarity: Contains 1 PPIase FKBP-type domain |
Function
for FKBP1A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FKB1A_HUMAN, P62942Function: Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventingTGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calciumchannel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of prolineimidic peptide bonds in oligopeptidesCatalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)Enzyme regulation: Inhibited by both FK506 and rapamycin Genatlas biochemistry entry for FKBP1A:FK506-binding protein 1A,T cell binding protein FKBP-12 for the immunosuppressive agents FK506-rapamycin ,withintrinsic peptidyl-prolyl cis-trans isomerase activity
Enzyme Number (IUBMB): EC 5.2.1.81 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP1A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP1A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector (see all 3): FKBP1A (NM_000801) | |  | Sino Biological Human cDNA Clone for FKBP1A | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FKBP1A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FKBP1A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBP1A |
Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13): About this table
FKBP1A for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Fkbp1atm1Zuk for FKBP1A
12 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Fkbp1a):
FKBP1A for phenotypes About GeneDecksing
|
Pathways & Interactions
for FKBP1A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/21 super-pathways (see all 21) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Development_TGF-beta receptor signaling | | | 2 | Signal transduction Activin A signaling regulation | | | 3 | Signal transduction Calcium signaling | | | 4 | Integrated Pancreatic Cancer Pathway | | | 5 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for FKBP1A
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for FKBP1A
3  GeneGo (Thomson Reuters) Pathways for FKBP1A
5/13  BioSystems Pathways for FKBP1A (see all 13)
4 
Reactome Pathways for FKBP1A
1  PharmGKB Pathway for FKBP1A
FKBP1A for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FKBP1A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/139 Interacting proteins for FKBP1A (P629422, 3 ENSP000003711384) via UniProtKB, MINT, STRING, and/or I2D (see all 139)About this table
Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24): About this table
FKBP1A for ontologies About GeneDecksing
|
Drugs & Compounds
for FKBP1A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
FKBP1A for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for FKBP1A |
Compounds for FKBP1A available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| Ascomycin | Calcineurin phosphatase inhibitor; analog of FK 506 (Cat. No. 3631) | [104987-12-4] |
1 HMDB Compound for FKBP1A About this table
10/15 DrugBank Compounds for FKBP1A (see all 15) About this table
| Compound | Synonyms |
CAS
# | Type | Actions | PubMed Ids |
|---|
| 4-Hydroxy-2-Butanone | -- | -- | target | -- | 17139284 17016423 10592235 | | FKB-001 | -- | -- | target | -- | 17139284 17016423 10592235 | | L-709,587 | -- | -- | target | -- | 17139284 17016423 10592235 | | Methyl Methylsulfinylmethyl Sulfide | -- | 33577-16-1 | target | -- | 17139284 17016423 10592235 | | {3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic Acid | -- | -- | target | -- | 17139284 17016423 10592235 | | Sirolimus | (-)-Rapamycin (see all 2) | 53123-88-9 | target | other | 11752352 12742462 | | Tacrolimus | FK-506 (see all 5) | 104987-11-3 | target | inhibitor | 16289353 17524933 | | (21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE | -- | -- | target | -- | 10592235 | | (3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Leucine | -- | -- | target | -- | 10592235 | | (3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Phenylalanine Ethyl Ester | -- | -- | target | -- | 10592235 |
10/30 Novoseek chemical compound relationships for FKBP1A gene (see all 30) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tacrolimus |
92.1 |
344 |
8545894 (5), 1379588 (5), 16246307 (4), 8563622 (4) (see all 99) |
| rapamycin |
89.3 |
209 |
10998178 (4), 10330150 (4), 11335722 (4), 8325502 (3) (see all 96) |
| ryanodine |
81.5 |
61 |
8599646 (4), 9743407 (4), 9461216 (4), 9502200 (3) (see all 36) |
| ascomycin |
75.4 |
3 |
10543889 (2), 9383417 (1) |
| everolimus |
61.4 |
1 |
16278292 (1) |
| cyclosporin a |
57.6 |
7 |
8794888 (1), 11982754 (1), 14523907 (1), 10412950 (1) (see all 6) |
| caffeine |
44.1 |
7 |
17950843 (2), 7527548 (1), 7514503 (1) |
| calcium |
44 |
70 |
7527548 (5), 16278292 (5), 8521476 (3), 7533300 (3) (see all 38) |
| inositol 1,4,5 trisphosphate |
43.7 |
6 |
9346894 (2), 9660798 (1), 9742506 (1), 11557049 (1) (see all 5) |
| dihydropyridine |
35.6 |
5 |
15269663 (1), 15998242 (1), 11751303 (1), 16621918 (1) |
Search CenterWatch for drugs/clinical trials and news about FKBP1A / FKB1A
|
Transcripts
for FKBP1A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FKBP1A gene (3 alternative transcripts): NM_000801.4 NM_001199786.1 NM_054014.3 Unigene Clusters for FKBP1A: FK506 binding protein 1A, 12kDa Hs.471933 [show with all ESTs], Hs.700839 [show with all ESTs]Unigene Representative Sequences: NM_000801, BM5421068 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000474657 ENST00000400137(uc010gac.2 uc002wey.3 uc002wez.3 uc010gaf.2 uc010gae.2)
ENST00000381724 ENST00000460490 ENST00000474726 ENST00000381719(uc002wfb.3 uc002wfa.3)
ENST00000381715 ENST00000439640
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP1A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP1A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): FKBP1A (NM_000801) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FKBP1A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FKBP1A |
Additional cDNA sequence: BC119733.1 24/39 DOTS entries (see all 39): DT.100870942 DT.100847570 DT.100854207 DT.87077786 DT.120799367 DT.100732414 DT.120799438 DT.100655249 DT.92459538 DT.100869037 DT.100655253 DT.95094918 DT.100732306 DT.95077610 DT.92459542 DT.97848563 DT.92459549 DT.95266874 DT.120799348 DT.120799430 DT.120799444 DT.92459530 DT.95346255 DT.100655250 24/1172 AceView cDNA sequences (see all 1172): CR600891 BU622760 CD721763 BM853527 AW272548 CR596571 AI796661 BG749120 AU117652 F08881 BM709447 BQ879875 AA354519 BX359084 CR591667 BG749775 F11218 AA376016 BX486223 BU541377 BM790715 AI092360 BM761572 AA165106
GeneLoc Exon Structure
|
Expression
for FKBP1A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FKBP1A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACAAATCCTT
About this image
See FKBP1A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FKBP1A
SOURCE GeneReport for Unigene clusters: Hs.471933 Hs.700839
SABiosciences Expression via Pathway-Focused PCR Arrays including FKBP1A:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FKBP1A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FKBP1A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FKBP1A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FKBP1A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBP1A |
Orthologs
for FKBP1A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for FKBP1A gene from 9/26 species (see all 26) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Fkbp1a1 , 5 |
FK506 binding protein 1a1, 5 |
93.21(n)1
97.22(a)1 |
|
2 (74.83 cM)5
142251 NM_008019.21 NP_032045.11
1515424835 |
chicken
(Gallus gallus) |
Aves |
FKBP1A1 |
FK506 binding protein 1A, 12kDa |
83.64(n)
91.67(a) |
|
374233 NM_204330.1 NP_989661.1 |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
89(a) |
1 → many |
GL343346.1(874569-875912) |
zebrafish
(Danio rerio) |
Actinopterygii |
fkbp1ab1 |
FK506 binding protein 1Ab |
72.22(n)
82.41(a) |
|
449552 NM_001005594.1 NP_001005594.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
FK506-bp23 |
protein folding FK506 binding |
75(a) |
|
56C8 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
fkb-23 |
FKBP-type peptidyl-prolyl cis-trans
isomerases |
60(a) |
|
I(12926778-12927157) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT3G555206 |
FKBP-like peptidyl-prolyl cis-trans isomerase fami... |
22(a) |
possible ortholog |
3(20593661-20595345) |
rice
(Oryza sativa) |
Liliopsida |
---- |
peptidyl-prolyl cis-trans isomerase, FKBP-type, pu...peptidyl-prolyl cis-trans isomerase, FKBP-type, pu... |
22(a)21(a) |
possible orthologpossible ortholog |
1(36252504-36255934) 5(22429840-22432453) |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
fklB6fkpA6 |
FKBP-type peptidyl-prolyl cis-trans isomerase (rot...FKBP-type peptidyl-prolyl cis-trans isomerase (rot... |
22(a)17(a) |
possible orthologpossible ortholog |
Chromosome(4426958-4427578) Chromosome(3474629-3475441) |
ENSEMBL Gene Tree for FKBP1A (if available)
TreeFam Gene Tree for FKBP1A (if available) |
Paralogs
for FKBP1A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FKBP1A gene
- FKBP52 FKBP42 FKBP1C2 FKBP82 FKBP62 FKBP1B2 FKBP32
16 SIMAP similar genes for FKBP1A using alignment to 4 protein entries: FKB1A_HUMAN (see all proteins):FKBP12-Exip3 FKBP12-Exin FKBP1C FKBP1B FKBP12-Exip2 FKBP4
FKBP6 FKBP5 FKBP2 FKBP7 FKBP14 FKBP9
FKBP10 DKFZp666D193 FKBP11 FKBP8
FKBP1A for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for FKBP1A
PGOHUM00000248586 PGOHUM00000246846 PGOHUM00000250590 PGOHUM00000250264
|
Genomic Variants
for FKBP1A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FKBP1A (1349622 - 1373816 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FKBP1A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FKBP1A |
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Disorders
/ Diseases
for FKBP1A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FKBP1A for disorders About GeneDecksing
OMIM gene information: 186945
OMIM disorders: --
20/27  diseases for FKBP1A (see all 27): About MalaCardsnoncompaction of left ventricular myocardium fibrodysplasia ossificans progressiva left ventricular noncompaction graft versus host disease
familial adenomatous polyposis ataxia telangiectasia corneal neovascularization tuberous sclerosis
neurodegenerative disease bipolar disorder diabetes mellitus neurodegeneration
polyneuropathy ataxia breast cancer rhabdomyosarcoma
polyposis ovarian cancer psoriasis prostate cancer
4 diseases from the University of Copenhagen DISEASES database for FKBP1A:Fibrodysplasia ossificans progressiva Polyneuropathy Malignant hyperthermia Familial adenomatous polyposis 10/12 Novoseek disease relationships for FKBP1A gene (see all 12) About this table
Human Genome Epidemiology (HuGE) Navigator: FKBP1A (5 documents)
Export disorders for FKBP1A gene to outside databases
|
Publications
for FKBP1A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FKBP1A gene, integrated from 9 sources (see all 339):
(articles sorted by number of sources associating them with FKBP1A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor. (PubMed id 16720724)1, 2, 9 Yamaguchi T....Sugino H. (2006)
- Exon organization of the human FKBP-12 gene: correlation with structural and functional protein domains. (PubMed id 1716149)1, 2, 9 Dilella A.G. and Craig R.J. (1991)
- Three distinct messenger RNAs can encode the human immunosuppressant- binding protein FKBP12. (PubMed id 7529739)1, 2, 9 Peattie D.A.... Lippke J.A. (1994)
- Solution structure of FK506 bound to FKBP-12. (PubMed id 1375171)1, 2, 9 Lepre C.A.... Moore J.M. (1992)
- Chromosomal assignment of the human immunophilin FKBP-12 gene. (PubMed id 1930186)1, 3, 9 DiLella A.G. (1991)
- Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels. (PubMed id 22100703)1, 2 Wen H.... Park S. (2012)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- X-ray structures of small ligand-FKBP complexes provide an estimate for hydrophobic interaction energies. (PubMed id 10656803)1, 2 Burkhard P.... Walkinshaw M.D. (2000)
|
External Searches for FKBP1A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FKBP1A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FKBP1A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FKBP1A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FKBP1A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FKBP1A gene:
Search GeneIP for patents involving FKBP1A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FKBP1A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | OriGene Antibodies for FKBP1A | | OriGene shRNA RFP for FKBP1A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FKBP1A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FKBP1A | | | OriGene Protein Over-expression Lysate for FKBP1A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FKBP1A | | OriGene 3'-UTR Clone for FKBP1A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP1A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP1A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FKBP1A | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FKBP1A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FKBP1A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FKBP1A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FKBP1A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FKBP1A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FKBP1A |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBP1A |
|  |  |  | | | | ThermoFisher Antibody for FKBP1A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FKBP1A |
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