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Aliases for FKBP1A Gene

Aliases for FKBP1A Gene

  • FK506 Binding Protein 1A, 12kDa 2 3
  • FKBP12 3 4 6
  • FK506-Binding Protein 1A (12kD) 2 3
  • 12 KDa FK506-Binding Protein 3 4
  • Immunophilin FKBP12 3 4
  • PPIase FKBP1A 3 4
  • Calstabin 1 2 3
  • 12 KDa FKBP 3 4
  • Calstabin-1 3 4
  • EC 5.2.1.8 4 64
  • Rotamase 3 4
  • FKBP-12 3 4
  • FKBP-1A 3 4
  • FKBP1 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase FKBP1A 3
  • FK506-Binding Protein, T-Cell, 12-KD 3
  • Protein Kinase C Inhibitor 2 3
  • FK506-Binding Protein 12 3
  • FK506-Binding Protein 1A 4
  • FK506 Binding Protein12 3
  • FK506-Binding Protein 1 3
  • FKBP12-Exip3 3
  • PPIASE 3
  • PKC12 3
  • PKCI2 3

External Ids for FKBP1A Gene

Previous Symbols for FKBP1A Gene

  • FKBP1

Summaries for FKBP1A Gene

Entrez Gene Summary for FKBP1A Gene

  • The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008]

GeneCards Summary for FKBP1A Gene

FKBP1A (FK506 Binding Protein 1A, 12kDa) is a Protein Coding gene. Diseases associated with FKBP1A include central core disease. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include signal transducer activity and SMAD binding. An important paralog of this gene is FKBP4.

UniProtKB/Swiss-Prot for FKBP1A Gene

  • Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Tocris Summary for FKBP1A Gene

  • Protein ser/thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of kinases and phosphorylases and therefore play an integral role in many signal transduction pathways. There are two groups of serine/threonine phosphatases; phosphoprotein phosphatases (e.g. PP1, calcineurin), which are sensitive to okadaic acid and metallo-phosphatases (e.g. PP2C), which require a divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This makes protein Ser/Thr phosphatases essential for many signal transduction pathways. Protein Ser/Thr phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are subtype-specific.

Gene Wiki entry for FKBP1A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBP1A Gene

Genomics for FKBP1A Gene

Genomic Location for FKBP1A Gene

Start:
1,368,977 bp from pter
End:
1,393,172 bp from pter
Size:
24,196 bases
Orientation:
Minus strand

Genomic View for FKBP1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FKBP1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP1A Gene

Regulatory Elements for FKBP1A Gene

Proteins for FKBP1A Gene

  • Protein details for FKBP1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62942-FKB1A_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP1A
    Protein Accession:
    P62942
    Secondary Accessions:
    • D3DVW6
    • P20071
    • Q4VC47
    • Q6FGD9
    • Q6LEU3
    • Q9H103
    • Q9H566

    Protein attributes for FKBP1A Gene

    Size:
    108 amino acids
    Molecular mass:
    11951 Da
    Quaternary structure:
    • Interacts directly with RYR1, RYR2 and RYR3. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1) (By similarity). Interacts with TGFBR1; prevents TGFBR1 phosphorylation by TGFBR2 and stabilizes it in the inactive conformation. Interacts with ACVR1B and SMAD7.

    Three dimensional structures from OCA and Proteopedia for FKBP1A Gene

neXtProt entry for FKBP1A Gene

Proteomics data for FKBP1A Gene at MOPED

Selected DME Specific Peptides for FKBP1A Gene

Post-translational modifications for FKBP1A Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys48 and Lys53

Other Protein References for FKBP1A Gene

Domains for FKBP1A Gene

Protein Domains for FKBP1A Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

FKB1A_HUMAN
Domain:
  • Contains 1 PPIase FKBP-type domain.:
    • P62942
Family:
  • Belongs to the FKBP-type PPIase family. FKBP1 subfamily.:
    • P62942
genes like me logo Genes that share domains with FKBP1A: view

No data available for Gene Families for FKBP1A Gene

Function for FKBP1A Gene

Molecular function for FKBP1A Gene

GENATLAS Biochemistry: FK506-binding protein 1A,T cell binding protein FKBP-12 for the immunosuppressive agents FK506-rapamycin ,with intrinsic peptidyl-prolyl cis-trans isomerase activity
UniProtKB/Swiss-Prot CatalyticActivity: Peptidylproline (omega=180) = peptidylproline (omega=0)
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by both FK506 and rapamycin
UniProtKB/Swiss-Prot Function: Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Enzyme Numbers (IUBMB) for FKBP1A Gene

Gene Ontology (GO) - Molecular Function for FKBP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity TAS 11322937
GO:0004871 signal transducer activity IMP 12761501
GO:0005024 transforming growth factor beta-activated receptor activity --
GO:0005160 transforming growth factor beta receptor binding TAS 11322937
GO:0005219 ryanodine-sensitive calcium-release channel activity --
genes like me logo Genes that share ontologies with FKBP1A: view
genes like me logo Genes that share phenotypes with FKBP1A: view

Animal Models for FKBP1A Gene

MGI Knock Outs for FKBP1A:

No data available for Transcription Factor Targeting and HOMER Transcription for FKBP1A Gene

Localization for FKBP1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP1A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FKBP1A Gene COMPARTMENTS Subcellular localization image for FKBP1A gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 4
nucleus 2
plasma membrane 2
cytoskeleton 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FKBP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12443530
GO:0005789 endoplasmic reticulum membrane IBA --
GO:0005829 cytosol TAS --
GO:0014802 terminal cisterna ISS 1374404
GO:0016020 membrane IDA 12443530
genes like me logo Genes that share ontologies with FKBP1A: view

Pathways for FKBP1A Gene

genes like me logo Genes that share pathways with FKBP1A: view

Gene Ontology (GO) - Biological Process for FKBP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IDA 1696686
GO:0001933 negative regulation of protein phosphorylation --
GO:0003007 heart morphogenesis ISS --
GO:0006457 protein folding NAS 1930186
GO:0006458 de novo protein folding TAS 11322937
genes like me logo Genes that share ontologies with FKBP1A: view

Compounds for FKBP1A Gene

(5) Tocris Compounds for FKBP1A Gene

Compound Action Cas Number
Calyculin A Protein phosphatase 1 and 2A inhibitor [101932-71-2]
Cyclosporin A Calcineurin inhibitor [59865-13-3]
FK 506 Potent calcineurin inhibitor; immunosuppressant [104987-11-3]
Okadaic acid Protein phosphatase 1 and 2A inhibitor [78111-17-8]
Salubrinal Selective inhibitor of eIF2alpha dephosphorylation [405060-95-9]

(1) HMDB Compounds for FKBP1A Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(30) Novoseek inferred chemical compound relationships for FKBP1A Gene

Compound -log(P) Hits PubMed IDs
tacrolimus 92.1 174
rapamycin 89.3 137
ryanodine 81.5 55
ascomycin 75.4 3
everolimus 61.4 1

(1) PharmGKB related drug/compound annotations for FKBP1A Gene

Drug/compound Annotation
everolimus
genes like me logo Genes that share compounds with FKBP1A: view

Transcripts for FKBP1A Gene

Unigene Clusters for FKBP1A Gene

FK506 binding protein 1A, 12kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP1A Gene

No ASD Table

Relevant External Links for FKBP1A Gene

GeneLoc Exon Structure for
FKBP1A
ECgene alternative splicing isoforms for
FKBP1A

Expression for FKBP1A Gene

mRNA expression in normal human tissues for FKBP1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FKBP1A Gene

SOURCE GeneReport for Unigene cluster for FKBP1A Gene Hs.471933

genes like me logo Genes that share expressions with FKBP1A: view

Orthologs for FKBP1A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FKBP1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FKBP1A 36
  • 100 (n)
  • 100 (a)
FKBP1A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 89 (a)
ManyToMany
FKBP1A 36
  • 94.14 (n)
  • 97.22 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 98 (a)
OneToMany
FKBP1A 36
  • 95.37 (n)
  • 99.07 (a)
mouse
(Mus musculus)
Mammalia Fkbp1a 36
  • 93.21 (n)
  • 97.22 (a)
Fkbp1a 16
Fkbp1a 37
  • 97 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 94 (a)
ManyToMany
-- 37
  • 77 (a)
ManyToMany
-- 37
  • 77 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Fkbp1a 36
  • 91.98 (n)
  • 97.22 (a)
chicken
(Gallus gallus)
Aves FKBP12 37
  • 91 (a)
OneToMany
FKBP1A 36
  • 83.64 (n)
  • 91.67 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 89 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii fkbp1ab 36
  • 72.22 (n)
  • 82.41 (a)
fkbp1ab 37
  • 81 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta FK506-bp2 37
  • 76 (a)
OneToMany
FK506-bp2 38
  • 75 (a)
worm
(Caenorhabditis elegans)
Secernentea fkb-8 37
  • 16 (a)
ManyToMany
fkb-2 38
  • 60 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPR1 37
  • 54 (a)
OneToMany
FPR1 39
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3865 37
  • 73 (a)
OneToMany
Species with no ortholog for FKBP1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FKBP1A Gene

ENSEMBL:
Gene Tree for FKBP1A (if available)
TreeFam:
Gene Tree for FKBP1A (if available)

Paralogs for FKBP1A Gene

Paralogs for FKBP1A Gene

Pseudogenes.org Pseudogenes for FKBP1A Gene

genes like me logo Genes that share paralogs with FKBP1A: view

Variants for FKBP1A Gene

Structural Variations from Database of Genomic Variants (DGV) for FKBP1A Gene

Variant ID Type Subtype PubMed ID
nsv522008 CNV Gain 19592680

Relevant External Links for FKBP1A Gene

HapMap Linkage Disequilibrium report
FKBP1A

No data available for Sequence variations from dbSNP and Humsavar for FKBP1A Gene

Disorders for FKBP1A Gene

(1) MalaCards Diseases for FKBP1A Gene

Search for FKBP1A Gene in MalaCards »

(12) Novoseek inferred disease relationships for FKBP1A Gene

Disease -log(P) Hits PubMed IDs
ataxia telangiectasia 30.7 2
neurodegenerative diseases 7.98 2
carcinoma 3.78 1
breast cancer 2.95 1
restenosis 2.94 1

Relevant External Links for FKBP1A

Genetic Association Database (GAD)
FKBP1A
Human Genome Epidemiology (HuGE) Navigator
FKBP1A
genes like me logo Genes that share disorders with FKBP1A: view

No data available for UniProtKB/Swiss-Prot for FKBP1A Gene

Publications for FKBP1A Gene

  1. Exon organization of the human FKBP-12 gene: correlation with structural and functional protein domains. (PMID: 1716149) Dilella A.G. … Craig R.J. (Biochemistry 1991) 3 4 23
  2. Chromosomal assignment of the human immunophilin FKBP-12 gene. (PMID: 1930186) DiLella A.G. (Biochem. Biophys. Res. Commun. 1991) 2 3 23
  3. Solution structure of FK506 bound to FKBP-12. (PMID: 1375171) Lepre C.A. … Moore J.M. (FEBS Lett. 1992) 3 4 23
  4. Three distinct messenger RNAs can encode the human immunosuppressant- binding protein FKBP12. (PMID: 7529739) Peattie D.A. … Lippke J.A. (Gene 1994) 3 4 23
  5. FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor. (PMID: 16720724) Yamaguchi T. … Sugino H. (J. Mol. Endocrinol. 2006) 3 4 23

Products for FKBP1A Gene

Sources for FKBP1A Gene

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