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Aliases for FKBP15 Gene

Aliases for FKBP15 Gene

  • FK506 Binding Protein 15 2 3 5
  • KIAA0674 2 3 4
  • Protein Phosphatase 1, Regulatory Subunit 76 2 3
  • FK506 Binding Protein 15, 133kDa 2 3
  • 133 KDa FK506-Binding Protein 3 4
  • WASP And FKBP-Like Protein 2 3
  • 133 KDa FKBP 3 4
  • FKBP-133 3 4
  • FKBP-15 3 4
  • WAFL 3 4
  • FK506-Binding Protein 133kDa 3
  • FK506-Binding Protein 15 3
  • WASP And FKBP-Like 4
  • FKBP133 3
  • PPP1R76 3

External Ids for FKBP15 Gene

Previous HGNC Symbols for FKBP15 Gene

  • KIAA0674

Previous GeneCards Identifiers for FKBP15 Gene

  • GC09M114968
  • GC09M115923
  • GC09M085535

Summaries for FKBP15 Gene

GeneCards Summary for FKBP15 Gene

FKBP15 (FK506 Binding Protein 15) is a Protein Coding gene. GO annotations related to this gene include actin binding and peptidyl-prolyl cis-trans isomerase activity.

UniProtKB/Swiss-Prot for FKBP15 Gene

  • May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBP15 Gene

Genomics for FKBP15 Gene

Regulatory Elements for FKBP15 Gene

Enhancers for FKBP15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F113255 0.2 Ensembl 11.3 -34.1 -34140 0.2 FKBP15 SLC31A1 CDC26 RNF183 ALAD PIR39900
GH09F113268 0.5 ENCODE 11.2 -48.3 -48287 1.3 ZBTB33 YY1 PRPF4 CDC26 WDR31 FKBP15 SLC31A1 RNF183 C9orf43 POLE3 PIR39900
GH09F113183 1 ENCODE 11.1 +36.6 36589 1.6 ELF3 THRB ZSCAN9 RARA CREM THAP11 SP5 CEBPB KAT8 TGIF2 SLC31A1 SLC31A2 FKBP15 PIR31842
GH09F113186 1.1 ENCODE 11.1 +33.4 33352 2.7 TAF1 ETV1 BHLHE40 CEBPB MAX ZNF175 GABPA JUND CTBP1 ATF3 SLC31A1 PRPF4 SLC31A2 FKBP15 RNF183 BSPRY HDHD3 PIR31842
GH09F112749 0.9 ENCODE 11.1 +470.5 470485 2.7 PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 KLF13 ZNF263 PRPF4 FKBP15 UGCG ENSG00000226609 ENSG00000271631 PIR49803
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FKBP15 on UCSC Golden Path with GeneCards custom track

Promoters for FKBP15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001474120 161 4401 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A YBX1 DMAP1 ZNF2

Genomic Location for FKBP15 Gene

Chromosome:
9
Start:
113,161,006 bp from pter
End:
113,221,361 bp from pter
Size:
60,356 bases
Orientation:
Minus strand

Genomic View for FKBP15 Gene

Genes around FKBP15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FKBP15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FKBP15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP15 Gene

Proteins for FKBP15 Gene

  • Protein details for FKBP15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T1M5-FKB15_HUMAN
    Recommended name:
    FK506-binding protein 15
    Protein Accession:
    Q5T1M5
    Secondary Accessions:
    • Q05DK8
    • Q5T1M2
    • Q6DD85
    • Q9Y4D0

    Protein attributes for FKBP15 Gene

    Size:
    1219 amino acids
    Molecular mass:
    133630 Da
    Quaternary structure:
    • Interacts with WIP and actin.
    SequenceCaution:
    • Sequence=AAH09609.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA31649.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI10963.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI10964.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FKBP15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FKBP15 Gene

Post-translational modifications for FKBP15 Gene

  • Ubiquitination at Lys 774
  • Modification sites at PhosphoSitePlus

Other Protein References for FKBP15 Gene

No data available for DME Specific Peptides for FKBP15 Gene

Domains & Families for FKBP15 Gene

Protein Domains for FKBP15 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FKBP15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T1M5

UniProtKB/Swiss-Prot:

FKB15_HUMAN :
  • The PPIase FKBP-type domain seems to be inactive both for FK506-binding and enzymatic activity.
  • Belongs to the FKBP-type PPIase family.
Domain:
  • The PPIase FKBP-type domain seems to be inactive both for FK506-binding and enzymatic activity.
  • The central coiled-coil region is responsible for association with early endosomes.
  • Contains 1 PPIase FKBP-type domain.
Family:
  • Belongs to the FKBP-type PPIase family.
genes like me logo Genes that share domains with FKBP15: view

Function for FKBP15 Gene

Molecular function for FKBP15 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement.

Gene Ontology (GO) - Molecular Function for FKBP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 22070227
genes like me logo Genes that share ontologies with FKBP15: view

Phenotypes for FKBP15 Gene

GenomeRNAi human phenotypes for FKBP15:
genes like me logo Genes that share phenotypes with FKBP15: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FKBP15

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FKBP15 Gene

Localization for FKBP15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP15 Gene

Cytoplasm. Cell projection, axon. Early endosome. Note=Present in axons and neuronal growth cones. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FKBP15 Gene COMPARTMENTS Subcellular localization image for FKBP15 gene
Compartment Confidence
endosome 4
nucleus 4
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for FKBP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA --
GO:0005884 actin filament IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with FKBP15: view

Pathways & Interactions for FKBP15 Gene

SuperPathways for FKBP15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FKBP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
GO:0006810 transport IEA --
GO:0006897 endocytosis IEA --
GO:0010923 negative regulation of phosphatase activity IDA 19389623
genes like me logo Genes that share ontologies with FKBP15: view

No data available for Pathways by source and SIGNOR curated interactions for FKBP15 Gene

Transcripts for FKBP15 Gene

Unigene Clusters for FKBP15 Gene

FK506 binding protein 15, 133kDa:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP15 Gene

No ASD Table

Relevant External Links for FKBP15 Gene

GeneLoc Exon Structure for
FKBP15
ECgene alternative splicing isoforms for
FKBP15

Expression for FKBP15 Gene

mRNA expression in normal human tissues for FKBP15 Gene

mRNA differential expression in normal tissues according to GTEx for FKBP15 Gene

This gene is overexpressed in Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for FKBP15 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.6) and Lymph node (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FKBP15 Gene



Protein tissue co-expression partners for FKBP15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FKBP15 Gene:

FKBP15

SOURCE GeneReport for Unigene cluster for FKBP15 Gene:

Hs.522351
genes like me logo Genes that share expression patterns with FKBP15: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FKBP15 Gene

Orthologs for FKBP15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FKBP15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FKBP15 34 35
  • 95.68 (n)
dog
(Canis familiaris)
Mammalia FKBP15 34 35
  • 87.08 (n)
cow
(Bos Taurus)
Mammalia FKBP15 34 35
  • 86.91 (n)
mouse
(Mus musculus)
Mammalia Fkbp15 34 16 35
  • 82.52 (n)
rat
(Rattus norvegicus)
Mammalia Fkbp15 34
  • 80.31 (n)
oppossum
(Monodelphis domestica)
Mammalia FKBP15 35
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FKBP15 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves FKBP15 34 35
  • 70.44 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 58 (a)
OneToMany
-- 35
  • 34 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fkbp15 34
  • 61.14 (n)
zebrafish
(Danio rerio)
Actinopterygii FKBP15 (1 of 4) 35
  • 67 (a)
OneToMany
LOC100330102 34
  • 59.88 (n)
FKBP15 (2 of 4) 35
  • 51 (a)
OneToMany
FKBP15 (4 of 4) 35
  • 42 (a)
OneToMany
FKBP15 (3 of 4) 35
  • 25 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta FK506-bp1 35
  • 18 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPR4 35
  • 19 (a)
OneToMany
FPR3 35
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToOne
Species where no ortholog for FKBP15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FKBP15 Gene

ENSEMBL:
Gene Tree for FKBP15 (if available)
TreeFam:
Gene Tree for FKBP15 (if available)

Paralogs for FKBP15 Gene

No data available for Paralogs for FKBP15 Gene

Variants for FKBP15 Gene

Sequence variations from dbSNP and Humsavar for FKBP15 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10081639 -- 113,209,464(+) TATGA(C/G)TTGGA intron-variant
rs10081701 -- 113,209,149(+) CATAG(C/T)TGCTG intron-variant
rs10114293 -- 113,204,245(+) gctaa(A/T)ttttt intron-variant
rs10114381 -- 113,213,692(+) GATGC(C/T)CCATG intron-variant
rs10114423 -- 113,213,751(+) CACAT(A/G)CAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FKBP15 Gene

Variant ID Type Subtype PubMed ID
dgv4129n106 CNV deletion 24896259
esv1117569 CNV deletion 17803354
esv2238231 CNV deletion 18987734
esv2564104 CNV insertion 19546169
esv2647679 CNV deletion 19546169
esv2738953 CNV deletion 23290073
esv2759710 CNV gain 17122850
esv3545338 CNV deletion 23714750
esv3621539 CNV loss 21293372
esv4206 CNV loss 18987735
esv7708 CNV loss 19470904
esv995741 CNV deletion 20482838
nsv1041112 CNV loss 25217958
nsv1051654 CNV gain 25217958
nsv1075669 CNV deletion 25765185
nsv1146531 CNV deletion 26484159
nsv466507 CNV loss 19166990
nsv615213 CNV loss 21841781
nsv831691 CNV loss 17160897
nsv957141 CNV deletion 24416366

Variation tolerance for FKBP15 Gene

Residual Variation Intolerance Score: 94.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.25; 95.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FKBP15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FKBP15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FKBP15 Gene

Disorders for FKBP15 Gene

Relevant External Links for FKBP15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FKBP15

No disorders were found for FKBP15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FKBP15 Gene

Publications for FKBP15 Gene

  1. The ulcerative colitis marker protein WAFL interacts with accessory proteins in endocytosis. (PMID: 20376207) Pan Y.F. … Maruyama I.N. (Int. J. Biol. Sci. 2010) 2 3 64
  2. WAFL, a new protein involved in regulation of early endocytic transport at the intersection of actin and microtubule dynamics. (PMID: 19121306) Viklund I.-M. … Pettersson S. (Exp. Cell Res. 2009) 3 4 64
  3. FKBP133: a novel mouse FK506-binding protein homolog alters growth cone morphology. (PMID: 16756961) Nakajima O. … Goshima Y. (Biochem. Biophys. Res. Commun. 2006) 2 3 64
  4. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 3 4 64
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64

Products for FKBP15 Gene

Sources for FKBP15 Gene

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