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FKBP15 Gene

protein-coding   GIFtS: 44
GCID: GC09M115923

FK506 Binding Protein 15, 133kDa

(Previous name: KIAA0674)
(Previous symbol: KIAA0674)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FK506 Binding Protein 15, 133kDa1 2     Regulatory Subunit 761
KIAA06741 2 3     FKBP1332
133 KDa FK506-Binding Protein2 3     PPP1R762
133 KDa FKBP2 3     FK506-Binding Protein 133kDa2
FKBP-1332 3     FK506-Binding Protein 152
FKBP-152 3     Protein Phosphatase 1, Regulatory Subunit 762
WAFL2 3     WASP And FKBP-Like3
Protein Phosphatase 11     

External Ids:    HGNC: 233971   Entrez Gene: 233072   Ensembl: ENSG000001193217   UniProtKB: Q5T1M53   

Export aliases for FKBP15 gene to outside databases

Previous GC identifers: GC09M114968 GC09M085535


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FKBP15 Gene:
FKBP15 (FK506 binding protein 15, 133kDa) is a protein-coding gene. GO annotations related to this gene include actin binding.

UniProtKB/Swiss-Prot: FKB15_HUMAN, Q5T1M5
Function: May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a
PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between
microfilament-based and microtubule-based movement




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FKBP15 gene promoter:
         E2F-3a   E2F-4   E2F-5   ATF-2   HSF1 (long)   E2F-2   C/EBPalpha   E2F   E2F-1   HSF1short   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FKBP15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FKBP15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q32   Ensembl cytogenetic band:  9q32   HGNC cytogenetic band: 9q33.1

FKBP15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FKBP15 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M115923:  view genomic region     (about GC identifiers)

Start:
115,923,286 bp from pter      End:
115,983,641 bp from pter
Size:
60,356 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FKB15_HUMAN, Q5T1M5 (See protein sequence)
Recommended Name: FK506-binding protein 15  
Size: 1219 amino acids; 133630 Da
Subunit: Interacts with WIP and actin
Sequence caution: Sequence=AAH09609.1; Type=Erroneous initiation; Sequence=BAA31649.1; Type=Erroneous initiation;
Sequence=CAI10963.1; Type=Erroneous initiation; Sequence=CAI10964.1; Type=Erroneous initiation;
Secondary accessions: Q05DK8 Q5T1M2 Q6DD85 Q9Y4D0
Alternative splicing: 3 isoforms:  Q5T1M5-1   Q5T1M5-2   Q5T1M5-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FKBP15: NX_Q5T1M5

Explore proteomics data for FKBP15 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys774
  • Modification sites at PhosphoSitePlus

  • See FKBP15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056073.1  
    ENSEMBL proteins: 
     ENSP00000416158   ENSP00000415733   ENSP00000238256  

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    antibodies-online antibodies for FKBP15 (19 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    1 InterPro protein domain:
     IPR001179 PPIase_FKBP_dom

    Graphical View of Domain Structure for InterPro Entry Q5T1M5

    ProtoNet protein and cluster: Q5T1M5

    UniProtKB/Swiss-Prot: FKB15_HUMAN, Q5T1M5
    Domain: The PPIase FKBP-type domain seems to be inactive both for FK506-binding and enzymatic activity (By
    similarity)
    Domain: The central coiled-coil region is responsible for association with early endosomes
    Similarity: Belongs to the FKBP-type PPIase family
    Similarity: Contains 1 PPIase FKBP-type domain


    Find genes that share domains with FKBP15           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FKB15_HUMAN, Q5T1M5
    Function: May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a
    PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between
    microfilament-based and microtubule-based movement

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
         
    Find genes that share ontologies with FKBP15           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FKBP15

    miRNA
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    miRTarBase miRNAs that target FKBP15:
    hsa-mir-192-5p (MIRT026296), hsa-mir-615-3p (MIRT040103)

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    Selected qRT-PCR Assays for microRNAs that regulate FKBP15 (see all 11):
    hsa-miR-3910 hsa-miR-622 hsa-miR-10b* hsa-miR-877* hsa-miR-124 hsa-miR-19b hsa-miR-193a-5p hsa-miR-506
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FKB15_HUMAN, Q5T1M5: Cytoplasm (By similarity). Cell projection, axon (By similarity). Early endosome.
    Note=Present in axons and neuronal growth cones (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    nucleus3
    cytoskeleton2
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005769early endosome IEA--
    GO:0005884actin filament IEA--
    GO:0030424axon IEA--
    GO:0030426growth cone IEA--

    Find genes that share ontologies with FKBP15           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FKBP15
    Interactions:

        Search GeneGlobe Interaction Network for FKBP15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FKBP15 (ENSP000002382564) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1CAENSP000003260314STRING: ENSP00000326031
    ACTA1ENSP000003556454STRING: ENSP00000355645
    ACTA2ENSP000002247844STRING: ENSP00000224784
    ACTC1ENSP000002903784STRING: ENSP00000290378
    ACTG1ENSP000003315144STRING: ENSP00000331514
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--
    GO:0006897endocytosis IEA--
    GO:0010923negative regulation of phosphatase activity IDA19389623
    GO:0038032termination of G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with FKBP15           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FKBP15 (FKB15)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FKBP15 gene: 
    NM_015258.1  

    Unigene Cluster for FKBP15:

    FK506 binding protein 15, 133kDa
    Hs.522351  [show with all ESTs]
    Unigene Representative Sequence: NM_015258
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000446284 ENST00000489645 ENST00000414250(uc004bgt.2) ENST00000493847
    ENST00000462889 ENST00000238256(uc004bgr.2 uc011lxc.1 uc004bgs.2 uc011lxd.1 uc010mut.1 uc010muu.1)

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    hsa-miR-3910 hsa-miR-622 hsa-miR-10b* hsa-miR-877* hsa-miR-124 hsa-miR-19b hsa-miR-193a-5p hsa-miR-506
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    Additional mRNA sequence: 

    AB014574.1 AK301208.1 AK303074.1 AK307498.1 AK307507.1 BC009609.1 BC026048.1 BC077732.1 

    10 DOTS entries:

    DT.86858127  DT.215140  DT.75150116  DT.95315561  DT.441359  DT.121207594  DT.91972528  DT.95122166 
    DT.95348663  DT.91798841 

    Selected AceView cDNA sequences (see all 183):

    BU617123 AL712410 AW574646 AI183857 BQ649332 BU622003 CA425081 AA614555 
    AI040563 BU186853 CB240858 CA308226 BQ682536 AI582182 BX097598 AW058387 
    BQ440039 BC009609 AL597437 BM552257 AW628156 AW779716 AB014574 CD366565 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FKBP15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATCTTCTTC
    FKBP15 Expression
    About this image

    FKBP15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FKBP15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522351
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FKBP15 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fkbp151 , 5 FK506 binding protein 151, 5 82.52(n)1
    80.26(a)1
      4 (33.08 cM)5
    3383551  NM_001045528.11  NP_001038993.11 
     623003425 
    chicken
    (Gallus gallus)
    Aves FKBP151 FK506 binding protein 15, 133kDa 70.44(n)
    69.05(a)
      417267  XM_004945776.1  XP_004945833.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    58(a)
    34(a)
    many → 1
    many → 1
    AAWZ02037538(1495-15911)
    GL344004.1(87921-96975)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fkbp151 FK506 binding protein 15, 133kDa 61.14(n)
    59.4(a)
      100496235  XM_002940731.2  XP_002940777.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003301021 FK506-binding protein 15-like 59.88(n)
    54.64(a)
      100330102  XM_002663250.3  XP_002663296.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta FK506-bp16
    FK506-binding protein 1
    18(a)
    1 ↔ 1
    3R(11157306-11158864)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FPR46
    FPR36
    Peptidyl-prolyl cis-trans isomerase (PPIase) (prol...
    Nucleolar peptidyl-prolyl cis-trans isomerase (PPI...
    19(a)
    17(a)
    many → 1
    many → 1
    XII(1030834-1032012) YLR449W
    XIII(120089-121324) YML074C


    ENSEMBL Gene Tree for FKBP15 (if available)
    TreeFam Gene Tree for FKBP15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FKBP15 (see all 1281)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105683411,2
    C--85572763(+) GATAG-/A/AA  
            
    AAAAA
    1 -- int10--------
    rs1390102281,2
    C--115927326(+) TATTC-/TGTT  
            
    TGTTT
    1 -- ds50010--------
    rs713026041,2
    C--115927327(-) TAAAA-/AAA   
      C
    /AACA
    AAACA
    1 -- ds50011NA 2
    rs106324941,2
    C--115927343(+) GACTG-/ATATTGC 1 -- ds50010--------
    rs339491941,2
    C--115927344(+) ACTGA-/AT/TA 
            
    TTGCA
    1 -- ds50011NA 2
    rs1158686961,2
    C,F--115927360(+) TTTGGA/GAGATC 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1915464831,2
    --115927551(+) AAGCCA/TGCAGG 1 -- ds50010--------
    rs1465507801,2
    --115927617(+) TAGGAA/CTACAG 1 -- ds50010--------
    rs1172119521,2
    C,F--115927648(+) CTAAAA/GGTTCC 1 -- ds50011Minor allele frequency- G:0.03NA 120
    rs2005220211,2
    --115927743(+) TTCCC-/AAAAAG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for FKBP15 (115923286 - 115983641 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FKBP15 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv4206CNV Deletion18987735
    esv2238231CNV Deletion18987734
    esv995741CNV Deletion20482838
    esv2738953CNV Deletion23290073
    esv2647679CNV Deletion19546169
    esv1117569CNV Deletion17803354
    esv2564104CNV Insertion19546169
    nsv893745CNV Loss21882294
    esv7708CNV Loss19470904
    nsv466507CNV Loss19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FKBP15 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with FKBP15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. WAFL, a new protein involved in regulation of early endocytic transport at the intersection of actin and microtubule dynamics. (PubMed id 19121306)1, 2 Viklund I.-M.... Pettersson S. (Exp. Cell Res. 2009)
    2. FKBP133: a novel mouse FK506-binding protein homolog alters growth cone morphology. (PubMed id 16756961)1, 3 Nakajima O....Goshima Y. (Biochem. Biophys. Res. Commun. 2006)
    3. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2 Ishikawa K.... Ohara O. (DNA Res. 1998)
    4. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    5. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cells. (PubMed id 22266860)1 Chuang J.Y....Hung J.J. (Oncogene 2012)
    8. Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35. (PubMed id 22070227)1 Harbour M.E....Seaman M.N. (Biochem. J. 2012)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23307 HGNC: 23397 AceView: KIAA0674 Ensembl:ENSG00000119321 euGenes: HUgn23307
    ECgene: FKBP15 H-InvDB: FKBP15

    (According to HUGE)
    About This Section

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    HUGE: KIAA0674

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FKBP15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FKBP15 gene:
    Search GeneIP for patents involving FKBP15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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