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Aliases for FKBP15 Gene

Aliases for FKBP15 Gene

  • FK506 Binding Protein 15, 133kDa 2 3
  • KIAA0674 2 3 4
  • 133 KDa FK506-Binding Protein 3 4
  • WASP And FKBP-Like Protein 2 3
  • 133 KDa FKBP 3 4
  • FKBP-133 3 4
  • FKBP-15 3 4
  • WAFL 3 4
  • Protein Phosphatase 1, Regulatory Subunit 76 3
  • FK506-Binding Protein 133kDa 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 76 2
  • WASP And FKBP-Like 4
  • FKBP133 3
  • PPP1R76 3

External Ids for FKBP15 Gene

Previous HGNC Symbols for FKBP15 Gene

  • KIAA0674

Previous GeneCards Identifiers for FKBP15 Gene

  • GC09M114968
  • GC09M115923
  • GC09M085535

Summaries for FKBP15 Gene

GeneCards Summary for FKBP15 Gene

FKBP15 (FK506 Binding Protein 15, 133kDa) is a Protein Coding gene. GO annotations related to this gene include actin binding and peptidyl-prolyl cis-trans isomerase activity.

UniProtKB/Swiss-Prot for FKBP15 Gene

  • May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBP15 Gene

Genomics for FKBP15 Gene

Regulatory Elements for FKBP15 Gene

Genomic Location for FKBP15 Gene

Chromosome:
9
Start:
113,161,006 bp from pter
End:
113,221,361 bp from pter
Size:
60,356 bases
Orientation:
Minus strand

Genomic View for FKBP15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FKBP15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP15 Gene

Proteins for FKBP15 Gene

  • Protein details for FKBP15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T1M5-FKB15_HUMAN
    Recommended name:
    FK506-binding protein 15
    Protein Accession:
    Q5T1M5
    Secondary Accessions:
    • Q05DK8
    • Q5T1M2
    • Q6DD85
    • Q9Y4D0

    Protein attributes for FKBP15 Gene

    Size:
    1219 amino acids
    Molecular mass:
    133630 Da
    Quaternary structure:
    • Interacts with WIP and actin.
    SequenceCaution:
    • Sequence=AAH09609.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA31649.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI10963.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI10964.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FKBP15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FKBP15 Gene

Proteomics data for FKBP15 Gene at MOPED

Post-translational modifications for FKBP15 Gene

  • Ubiquitination at Lys 774
  • Modification sites at PhosphoSitePlus

Other Protein References for FKBP15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FKBP15 Gene

Domains & Families for FKBP15 Gene

Protein Domains for FKBP15 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FKBP15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T1M5

UniProtKB/Swiss-Prot:

FKB15_HUMAN :
  • The PPIase FKBP-type domain seems to be inactive both for FK506-binding and enzymatic activity.
  • Belongs to the FKBP-type PPIase family.
Domain:
  • The PPIase FKBP-type domain seems to be inactive both for FK506-binding and enzymatic activity.
  • The central coiled-coil region is responsible for association with early endosomes
  • Contains 1 PPIase FKBP-type domain.
Family:
  • Belongs to the FKBP-type PPIase family.
genes like me logo Genes that share domains with FKBP15: view

Function for FKBP15 Gene

Molecular function for FKBP15 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement.

Gene Ontology (GO) - Molecular Function for FKBP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity --
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 22070227
genes like me logo Genes that share ontologies with FKBP15: view

Phenotypes for FKBP15 Gene

GenomeRNAi human phenotypes for FKBP15:
genes like me logo Genes that share phenotypes with FKBP15: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FKBP15 Gene

Localization for FKBP15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP15 Gene

Cytoplasm. Cell projection, axon. Early endosome. Note=Present in axons and neuronal growth cones. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FKBP15 Gene COMPARTMENTS Subcellular localization image for FKBP15 gene
Compartment Confidence
endosome 3
cytoskeleton 2
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for FKBP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IEA --
GO:0005884 actin filament IEA --
GO:0016020 membrane IDA 19946888
GO:0030424 axon IEA --
GO:0030426 growth cone IEA --
genes like me logo Genes that share ontologies with FKBP15: view

Pathways & Interactions for FKBP15 Gene

SuperPathways for FKBP15 Gene

No Data Available

Interacting Proteins for FKBP15 Gene

Gene Ontology (GO) - Biological Process for FKBP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization --
GO:0006457 protein folding IEA --
GO:0006897 endocytosis IEA --
GO:0010923 negative regulation of phosphatase activity IDA 19389623
genes like me logo Genes that share ontologies with FKBP15: view

No data available for Pathways by source and SIGNOR curated interactions for FKBP15 Gene

Drugs & Compounds for FKBP15 Gene

No Compound Related Data Available

Transcripts for FKBP15 Gene

Unigene Clusters for FKBP15 Gene

FK506 binding protein 15, 133kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP15 Gene

No ASD Table

Relevant External Links for FKBP15 Gene

GeneLoc Exon Structure for
FKBP15
ECgene alternative splicing isoforms for
FKBP15

Expression for FKBP15 Gene

mRNA expression in normal human tissues for FKBP15 Gene

mRNA differential expression in normal tissues according to GTEx for FKBP15 Gene

This gene is overexpressed in Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for FKBP15 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.6) and Lymph node (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FKBP15 Gene



SOURCE GeneReport for Unigene cluster for FKBP15 Gene Hs.522351

genes like me logo Genes that share expression patterns with FKBP15: view

Protein tissue co-expression partners for FKBP15 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FKBP15 Gene

Orthologs for FKBP15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FKBP15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FKBP15 35
  • 86.91 (n)
  • 84.19 (a)
FKBP15 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FKBP15 35
  • 87.08 (n)
  • 84.25 (a)
FKBP15 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fkbp15 35
  • 82.52 (n)
  • 80.26 (a)
Fkbp15 16
Fkbp15 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FKBP15 35
  • 95.68 (n)
  • 94.54 (a)
FKBP15 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fkbp15 35
  • 80.31 (n)
  • 76.11 (a)
oppossum
(Monodelphis domestica)
Mammalia FKBP15 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FKBP15 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves FKBP15 35
  • 70.44 (n)
  • 69.05 (a)
FKBP15 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 58 (a)
OneToMany
-- 36
  • 34 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fkbp15 35
  • 61.14 (n)
  • 59.4 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100330102 35
  • 59.88 (n)
  • 54.64 (a)
FKBP15 (1 of 4) 36
  • 67 (a)
OneToMany
FKBP15 (2 of 4) 36
  • 51 (a)
OneToMany
FKBP15 (3 of 4) 36
  • 25 (a)
OneToMany
FKBP15 (4 of 4) 36
  • 42 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta FK506-bp1 36
  • 18 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPR3 36
  • 17 (a)
OneToMany
FPR4 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToOne
Species with no ortholog for FKBP15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FKBP15 Gene

ENSEMBL:
Gene Tree for FKBP15 (if available)
TreeFam:
Gene Tree for FKBP15 (if available)

Paralogs for FKBP15 Gene

No data available for Paralogs for FKBP15 Gene

Variants for FKBP15 Gene

Sequence variations from dbSNP and Humsavar for FKBP15 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs4184 -- 113,165,735(+) AGGTA(-/GAG)GAGGG cds-indel
rs1128116 - 113,171,700(-) GTTTA(G/T)CCCTC reference, missense
rs74440977 -- 113,192,020(+) TTAAA(A/G)AAAAC intron-variant
rs76778382 -- 113,208,265(+) CTGGG(A/C)GGCAG intron-variant
rs76878726 -- 113,199,994(+) AAATG(G/T)AGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FKBP15 Gene

Variant ID Type Subtype PubMed ID
dgv2412e1 CNV Complex 17122850
nsv831691 CNV Loss 17160897
nsv483127 CNV Complex 15286789
dgv2416e1 CNV Complex 17122850
nsv466507 CNV Loss 19166990
nsv893744 CNV Gain 21882294
esv2647679 CNV Deletion 19546169
esv2238231 CNV Deletion 18987734
esv4206 CNV Deletion 18987735
esv2738953 CNV Deletion 23290073
esv7708 CNV Loss 19470904
esv995741 CNV Deletion 20482838
esv1117569 CNV Deletion 17803354
nsv893745 CNV Loss 21882294
esv2564104 CNV Insertion 19546169
nsv893746 CNV Gain 21882294

Variation tolerance for FKBP15 Gene

Residual Variation Intolerance Score: 94.91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.25; 95.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FKBP15 Gene

HapMap Linkage Disequilibrium report
FKBP15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FKBP15 Gene

Disorders for FKBP15 Gene

Relevant External Links for FKBP15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FKBP15
genes like me logo Genes that share disorders with FKBP15: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FKBP15 Gene

Publications for FKBP15 Gene

  1. The ulcerative colitis marker protein WAFL interacts with accessory proteins in endocytosis. (PMID: 20376207) Pan Y.F. … Maruyama I.N. (Int. J. Biol. Sci. 2010) 2 67
  2. FKBP133: a novel mouse FK506-binding protein homolog alters growth cone morphology. (PMID: 16756961) Nakajima O. … Goshima Y. (Biochem. Biophys. Res. Commun. 2006) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  5. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. (PMID: 24332808) Marechal A. … Zou L. (Mol. Cell 2014) 67

Products for FKBP15 Gene

Sources for FKBP15 Gene

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