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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FKBP15 Gene

protein-coding   GIFtS: 43
GCID: GC09M115923

FK506 Binding Protein 15, 133kDa

(Previous name: KIAA0674)
(Previous symbol: KIAA0674)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
FK506 Binding Protein 15, 133kDa1 2     Regulatory Subunit 761
KIAA06741 2 3     FKBP1332
133 KDa FK506-Binding Protein2 3     PPP1R762
133 KDa FKBP2 3     FK506-Binding Protein 133kDa2
FKBP-1332 3     FK506-Binding Protein 152
FKBP-152 3     Protein Phosphatase 1, Regulatory Subunit 762
WAFL2 3     WASP And FKBP-Like3
Protein Phosphatase 11     

External Ids:    HGNC: 233971   Entrez Gene: 233072   Ensembl: ENSG000001193217   UniProtKB: Q5T1M53   

Export aliases for FKBP15 gene to outside databases

Previous GC identifers: GC09M114968 GC09M085535


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FKBP15 Gene: 
FKBP15 (FK506 binding protein 15, 133kDa) is a protein-coding gene. Diseases associated with FKBP15 include wiskott-aldrich syndrome, and ulcerative colitis. GO annotations related to this gene include actin binding.

UniProtKB/Swiss-Prot: FKB15_HUMAN, Q5T1M5
Function: May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a
PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between
microfilament-based and microtubule-based movement




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FKBP15 gene promoter:
         E2F-3a   E2F-4   E2F-5   ATF-2   HSF1 (long)   E2F-2   C/EBPalpha   E2F   E2F-1   HSF1short   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FKBP15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FKBP15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q32   Ensembl cytogenetic band:  9q32   HGNC cytogenetic band: 9q33.1

FKBP15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FKBP15 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M115923:  view genomic region     (about GC identifiers)

Start:
115,923,286 bp from pter      End:
115,983,641 bp from pter
Size:
60,356 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FKB15_HUMAN, Q5T1M5 (See protein sequence)
Recommended Name: FK506-binding protein 15  
Size: 1219 amino acids; 133630 Da
Subunit: Interacts with WIP and actin
Subcellular location: Cytoplasm (By similarity). Cell projection, axon (By similarity). Early endosome.
Note=Present in axons and neuronal growth cones (By similarity)
Sequence caution: Sequence=AAH09609.1; Type=Erroneous initiation; Sequence=BAA31649.1; Type=Erroneous initiation;
Sequence=CAI10963.1; Type=Erroneous initiation; Sequence=CAI10964.1; Type=Erroneous initiation;
Secondary accessions: Q05DK8 Q5T1M2 Q6DD85 Q9Y4D0
Alternative splicing: 3 isoforms:  Q5T1M5-1   Q5T1M5-2   Q5T1M5-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FKBP15: NX_Q5T1M5

Explore proteomics data for FKBP15 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5T1M5

  • FKBP15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FKBP15 Protein Expression
    REFSEQ proteins: NP_056073.1  
    ENSEMBL proteins: 
     ENSP00000416158   ENSP00000415733   ENSP00000238256  

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    Cloud-Clone Corp. Proteins for FKBP15 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005769early endosome IEA--
    GO:0005884actin filament IEA--
    GO:0030424axon IEA--
    GO:0030426growth cone IEA--

    FKBP15 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    1 InterPro protein domain:
     IPR001179 PPIase_FKBP_dom

    Graphical View of Domain Structure for InterPro Entry Q5T1M5

    ProtoNet protein and cluster: Q5T1M5

    UniProtKB/Swiss-Prot: FKB15_HUMAN, Q5T1M5
    Domain: The PPIase FKBP-type domain seems to be inactive both for FK506-binding and enzymatic activity (By
    similarity)
    Domain: The central coiled-coil region is responsible for association with early endosomes
    Similarity: Belongs to the FKBP-type PPIase family
    Similarity: Contains 1 PPIase FKBP-type domain


    FKBP15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FKB15_HUMAN, Q5T1M5
    Function: May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a
    PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between
    microfilament-based and microtubule-based movement

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
         
    FKBP15 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FKBP15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/46 Interacting proteins for FKBP15 (ENSP000002382564) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1CAENSP000003260314STRING: ENSP00000326031
    ACTA1ENSP000003556454STRING: ENSP00000355645
    ACTA2ENSP000002247844STRING: ENSP00000224784
    ACTC1ENSP000002903784STRING: ENSP00000290378
    ACTG1ENSP000003315144STRING: ENSP00000331514
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--
    GO:0006897endocytosis IEA--
    GO:0010923negative regulation of phosphatase activity IDA19389623
    GO:0038032termination of G-protein coupled receptor signaling pathway ----

    FKBP15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for FKBP15 (FKB15)

    Search CenterWatch for drugs/clinical trials and news about FKBP15 / FKB15

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FKBP15 gene: 
    NM_015258.1  

    Unigene Cluster for FKBP15:

    FK506 binding protein 15, 133kDa
    Hs.522351  [show with all ESTs]
    Unigene Representative Sequence: NM_015258
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000446284 ENST00000489645 ENST00000414250(uc004bgt.2) ENST00000493847
    ENST00000462889 ENST00000238256(uc004bgr.2 uc011lxc.1 uc004bgs.2 uc011lxd.1 uc010mut.1 uc010muu.1)

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    Additional mRNA sequence: 

    AB014574.1 AK301208.1 AK303074.1 AK307498.1 AK307507.1 BC009609.1 BC026048.1 BC077732.1 

    10 DOTS entries:

    DT.86858127  DT.215140  DT.75150116  DT.95315561  DT.441359  DT.121207594  DT.91972528  DT.95122166 
    DT.95348663  DT.91798841 

    24/183 AceView cDNA sequences (see all 183):

    BQ679691 AA370547 BQ646813 CA308226 BU186853 AA999743 CD366565 BC009609 
    AL712410 AW574646 BQ019682 CB240858 BM993616 AA864366 AA614555 BU617123 
    AI582182 AA343841 AI183857 AW058387 BM794406 CA425081 BF088602 BQ682536 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FKBP15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATCTTCTTC
    FKBP15 Expression
    About this image


    See FKBP15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FKBP15

    SOURCE GeneReport for Unigene cluster: Hs.522351
        SABiosciences Custom PCR Arrays for FKBP15
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FKBP15 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fkbp151 , 5 FK506 binding protein 151, 5 82.91(n)1
    80.43(a)1
      4 (33.08 cM)5
    3383551  NM_001045528.11  NP_001038993.11 
     623003425 
    chicken
    (Gallus gallus)
    Aves FKBP151 FK506 binding protein 15, 133kDa 64.55(n)
    61.32(a)
      417267  XM_415541.3  XP_415541.3 
    lizard
    (Anolis carolinensis)
    Reptilia FKBP156
    --
    --
    57(a)
    34(a)
    1 ↔ 1
    possible ortholog
    AAWZ02037538(1495-15911)
    GL344004.1(87921-96975)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7999231 uncharacterized LOC799923 53.16(n)
    42.5(a)
      799923  XM_001340191.3  XP_001340227.3 


    ENSEMBL Gene Tree for FKBP15 (if available)
    TreeFam Gene Tree for FKBP15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1281 SNPs in FKBP15 are shown (see all 1281)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105683411,2
    C--85572763(+) GATAG-/A/AA  
            
    AAAAA
    1 -- int10--------
    rs1390102281,2
    C--115927326(+) TATTC-/TGTT  
            
    TGTTT
    1 -- ds50010--------
    rs713026041,2
    C--115927327(-) TAAAA-/AAA   
      C
    /AACA
    AAACA
    1 -- ds50011NA 2
    rs106324941,2
    C--115927343(+) GACTG-/ATATTGC 1 -- ds50010--------
    rs339491941,2
    C--115927344(+) ACTGA-/AT/TA 
            
    TTGCA
    1 -- ds50011NA 2
    rs1158686961,2
    C,F--115927360(+) TTTGGA/GAGATC 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1915464831,2
    --115927551(+) AAGCCA/TGCAGG 1 -- ds50010--------
    rs1465507801,2
    --115927617(+) TAGGAA/CTACAG 1 -- ds50010--------
    rs1172119521,2
    C,F--115927648(+) CTAAAA/GGTTCC 1 -- ds50011Minor allele frequency- G:0.03NA 120
    rs2005220211,2
    --115927743(+) TTCCC-/AAAAAG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for FKBP15 (115923286 - 115983641 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/16 variations for FKBP15 (see all 16):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv4206CNV Deletion18987735
    esv2238231CNV Deletion18987734
    esv995741CNV Deletion20482838
    esv2738953CNV Deletion23290073
    esv2647679CNV Deletion19546169
    esv1117569CNV Deletion17803354
    esv2564104CNV Insertion19546169
    nsv893745CNV Loss21882294
    esv7708CNV Loss19470904
    nsv466507CNV Loss19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for FKBP15:    About MalaCards
    wiskott-aldrich syndrome    ulcerative colitis    neuronitis


    FKBP15 for disorders           About GeneDecksing


    Export disorders for FKBP15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FKBP15 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with FKBP15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. WAFL, a new protein involved in regulation of early endocytic transport at the intersection of actin and microtubule dynamics. (PubMed id 19121306)1, 2 Viklund I.-M.... Pettersson S. (2009)
    2. FKBP133: a novel mouse FK506-binding protein homolog alters growth cone morphology. (PubMed id 16756961)1, 3 Nakajima O....Goshima Y. (2006)
    3. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2 Ishikawa K.... Ohara O. (1998)
    4. VCP phosphorylation-dependent interaction partners pre vent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (2013)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Sp1 phosphorylation by cyclin-dependent kinase 1/cycli n B1 represses its DNA-binding activity during mitosis in cancer cells. (PubMed id 22266860)1 Chuang J.Y....Hung J.J. (2012)
    7. Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35. (PubMed id 22070227)1 Harbour M.E....Seaman M.N. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23307 HGNC: 23397 AceView: KIAA0674 Ensembl:ENSG00000119321 euGenes: HUgn23307
    ECgene: FKBP15 H-InvDB: FKBP15

    (According to HUGE)
    About This Section
    HUGE: KIAA0674

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FKBP15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FKBP15 gene:
    Search GeneIP for patents involving FKBP15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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