FKBP15 Gene
protein-coding GIFtS: 41
GCID: GC09M115923
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FK506 binding protein 15, 133kDa(Previous name: KIAA0674 )
(Previous symbol: KIAA0674)
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Aliases
for FKBP15 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| FK506 Binding Protein 15, 133kDa1 2 | | WAFL2 3 | | KIAA06741 2 3 | | FKBP1332 | | PPP1R761 2 | | FK506-Binding Protein 133kDa2 | | 133 KDa FK506-Binding Protein2 3 | | FK506-Binding Protein 152 | | 133 KDa FKBP2 3 | | Protein Phosphatase 1, Regulatory Subunit 762 | | FKBP-1332 3 | | WASP And FKBP-Like3 | | FKBP-152 3 | | |
Export aliases for FKBP15 gene to outside databasesPrevious GC identifers: GC09M114968 GC09M085535 |
Summaries
for FKBP15 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FKB15_HUMAN, Q5T1M5Function: May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase(By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-basedand microtubule-based movement
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Genomic Views
for FKBP15 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FKBP15 gene promoter:
E2F-3a E2F-4 E2F-5 ATF-2 HSF1 (long) E2F-2 C/EBPalpha E2F E2F-1 HSF1short
Other transcription factors
Search SABiosciences Chromatin IP Primers for FKBP15
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FKBP15 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q32 Ensembl cytogenetic band: 9q32 HGNC cytogenetic band: 9q33.1FKBP15 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M115923: view genomic region
(about GC identifiers)
Start:
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115,923,286 bp from pter |
End:
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115,983,641 bp from pter |
Size:
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60,356 bases |
Orientation:
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minus strand |
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Proteins
for FKBP15 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FKB15_HUMAN, Q5T1M5 (See
protein sequence)Recommended Name: FK506-binding protein 15 Size: 1219 amino acids; 133630 Da
Subunit: Interacts with WIP and actin
Subcellular location: Cytoplasm (By similarity). Cell projection, axon (By similarity). Early endosome. Note=Present inaxons and neuronal growth cones (By similarity)
Sequence caution: Sequence=AAH09609.1; Type=Erroneous initiation; Sequence=BAA31649.1; Type=Erroneous initiation;Sequence=CAI10963.1; Type=Erroneous initiation; Sequence=CAI10964.1; Type=Erroneous initiation;
Secondary accessions: Q05DK8 Q5T1M2 Q6DD85 Q9Y4D0Alternative splicing: 3 isoforms: Q5T1M5-1 Q5T1M5-2 Q5T1M5-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FKBP15: NX_Q5T1M5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5T1M5
FKBP15 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056073.1
ENSEMBL proteins: ENSP00000416158 ENSP00000415733 ENSP00000238256
Human Recombinant Protein Products for FKBP15:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
FKBP15 for ontologies About GeneDecksing
FKBP15 Antibody Products:
Assay Products for FKBP15: |
Protein
Domains /
Families
for FKBP15 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FKBP15 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5T1M5ProtoNet protein and cluster: Q5T1M5 UniProtKB/Swiss-Prot: FKB15_HUMAN, Q5T1M5Domain: The PPIase FKBP-type domain seems to be inactive both for FK506-binding and enzymatic activity (By similarity)Domain: The central coiled-coil region is responsible for association with early endosomesSimilarity: Belongs to the FKBP-type PPIase familySimilarity: Contains 1 PPIase FKBP-type domain |
Function
for FKBP15 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: FKB15_HUMAN, Q5T1M5Function: May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase(By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-basedand microtubule-based movement Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003779 | actin binding |
IEA | -- |
FKBP15 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP15 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP15
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for FKBP15 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FKBP15 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBP15 |
|
Pathways & Interactions
for FKBP15 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FKBP15
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/46 Interacting proteins for FKBP15 (ENSP000002382564) via UniProtKB, MINT, STRING, and/or I2D (see all 46)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
FKBP15 for ontologies About GeneDecksing
|
Drugs & Compounds
for FKBP15 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FKBP15
Search CenterWatch for drugs/clinical trials and news about FKBP15 / FKB15
|
Transcripts
for FKBP15 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FKBP15 gene: NM_015258.1 Unigene Cluster for FKBP15: FK506 binding protein 15, 133kDa Hs.522351 [show with all ESTs]Unigene Representative Sequence: NM_0152586 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000446284 ENST00000489645 ENST00000414250(uc004bgt.2) ENST00000493847
ENST00000462889 ENST00000238256(uc004bgr.2 uc011lxc.1 uc004bgs.2 uc011lxd.1 uc010mut.1 uc010muu.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP15 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP15
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FKBP15 (NM_015258) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FKBP15 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FKBP15 |
Additional cDNA sequence: AB014574.1 AK301208.1 AK303074.1 AK307498.1 AK307507.1 BC009609.1 BC026048.1 BC077732.1 10 DOTS entries: DT.86858127 DT.215140 DT.75150116 DT.95315561 DT.441359 DT.121207594 DT.91972528 DT.95122166 DT.95348663 DT.91798841 24/183 AceView cDNA sequences (see all 183): AA343841 BM993616 CB240858 AL597437 AW771670 AI040563 AB014574 AW779716 AA614555 BQ649332 BQ679691 AW058387 BX097598 BQ019682 CA425081 CD172510 BQ648186 AW574646 BU186853 BQ682536 BF088602 BQ440039 BM794406 CA308226
GeneLoc Exon Structure
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Expression
for FKBP15 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FKBP15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATCTTCTTC
About this image
See FKBP15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FKBP15
SOURCE GeneReport for Unigene cluster: Hs.522351
SABiosciences Custom PCR Arrays for FKBP15
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FKBP15
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FKBP15 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FKBP15 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FKBP15 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBP15 |
Orthologs
for FKBP15 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FKBP15 gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for FKBP15 (if available)
TreeFam Gene Tree for FKBP15 (if available) |
Paralogs
for FKBP15 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for FKBP15 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FKBP15 (115923286 - 115983641 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for FKBP15
4 CNVs: 3779 4652 0131 100759
6 Indels: 41200 100760 29041 47632 42224 62943 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FKBP15 |
|
Disorders
/ Diseases
for FKBP15 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FKBP15 for disorders About GeneDecksing
3  diseases for FKBP15: About MalaCardswiskott-aldrich syndrome ulcerative colitis neuronitis
Export disorders for FKBP15 gene to outside databases
|
Publications
for FKBP15 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FKBP15 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with FKBP15) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- WAFL, a new protein involved in regulation of early endocytic transport at the intersection of actin and microtubule dynamics. (PubMed id 19121306)1, 2 Viklund I.-M.... Pettersson S. (2009)
- FKBP133: a novel mouse FK506-binding protein homolog alters growth cone morphology. (PubMed id 16756961)1, 3 Nakajima O....Goshima Y. (2006)
- Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2 Ishikawa K.... Ohara O. (1998)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Sp1 phosphorylation by cyclin-dependent kinase 1/cycli n B1 represses its DNA-binding activity during mitosis in cancer cells. (PubMed id 22266860)1 Chuang J.Y....Hung J.J. (2012)
- Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35. (PubMed id 22070227)1 Harbour M.E....Seaman M.N. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
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External Searches for FKBP15 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing FKBP15 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FKBP15 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing FKBP15 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FKBP15 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FKBP15 gene:
Search GeneIP for patents involving FKBP15
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FKBP15 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for FKBP15 | | OriGene shRNA RFP for FKBP15 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FKBP15 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FKBP15 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FKBP15 | | OriGene 3'-UTR Clone for FKBP15 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP15 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP15 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | FKBP15 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBP15 |
|  |  |  |  | | | | ThermoFisher Antibodies for FKBP15 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FKBP15 |
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