FKBP14 Gene

Aliases
for FKBP14 gene

Previous GC identifers: GC07M029695 GC07M029795 GC07M029826 GC07M030019

Summaries
for FKBP14 gene

Genomic Views
for FKBP14 gene

RefSeq DNA sequence:

NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  

SwitchGear Promoter luciferase reporter plasmid: FKBP14 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FKBP14

FKBP14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M030050:  view genomic region     (about GC identifiers)

Proteins
for FKBP14 gene

1 PDB 3D structure from and Proteopedia for FKBP14:

4DIP (3D)    

Explore the universe of human proteins at neXtProt for FKBP14: NX_Q9NWM8

Post-translational modifications:

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	OriGene Purified Protein: FKBP14 OriGene Protein Over-expression Lysate: FKBP14 OriGene Custom Protein Services for FKBP14
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	Novus Biologicals FKBP14 Proteins Novus Biologicals FKBP14 Lysates
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	ProSpec Recombinant Protein for FKBP14
	Uscn Proteins for FKBP14

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

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	ThermoFisher Antibodies for FKBP14

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	GenScript Custom Assay Services for FKBP14
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	Uscn ELISAs and CLIAs for FKBP14

Protein Domains /
Families
for FKBP14 gene

ProtoNet protein and cluster: Q9NWM8

Function
for FKBP14 gene

Enzyme Number (IUBMB): EC 5.2.1.8¹

miRNA Products:		OriGene 3'-UTR Clone: FKBP14 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FKBP14
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate FKBP14 (see all 12):
		hsa-miR-3671 hsa-miR-3163 hsa-miR-607 hsa-miR-520d-5p hsa-miR-3647-3p hsa-miR-1305 hsa-miR-4310 hsa-miR-524-5p
		SwitchGear 3'UTR luciferase reporter plasmid: FKBP14 3' UTR sequence

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FKBP14 (see all 6) OriGene siRNA: FKBP14
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FKBP14

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for FKBP14

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP14 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP14 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FKBP14 (NM_017946)
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBP14

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

Pathways & Interactions
for FKBP14 gene

	Super-pathway	contained gene-specific pathways
1	Activation of Chaperone Genes by XBP1(S)	Activation of Chaperone Genes by XBP1(S) 1.00 Unfolded Protein Response 0.71 Activation of Chaperones by IRE1alpha 0.94
2	Expression of FKBP14	Expression of FKBP14 1.00
3	Asparagine N-linked glycosylation	Metabolism of proteins 0.15

5        Reactome Pathways for FKBP14

	Activation of Chaperone Genes by XBP1(S)
	Metabolism of proteins
	Activation of Chaperones by IRE1alpha
	Expression of FKBP14
	Unfolded Protein Response

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for FKBP14 gene

Transcripts
for FKBP14 gene

Expression
for FKBP14 gene

FKBP14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGCTTTGGT

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BoneThoracic Rib			Bone
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FKBP14 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FKBP14
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FKBP14

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBP14

Orthologs
for FKBP14 gene

Paralogs
for FKBP14 gene

Paralogs for FKBP14 gene

FKBP11²  FKBP2²  FKBP10²  FKBP7²  FKBP9²  

11 SIMAP similar genes for FKBP14 using alignment to 3 protein entries:     FKB14_HUMAN (see all proteins):

FKBP7    FKBP2    FKBP1C    FKBP10    FKBP12-Exip2    FKBP1A

FKBP1B    DKFZp666D193    FKBP11    FKBP9    FKBP4

FKBP14 for paralogs           About GeneDecksing

Genomic Variants
for FKBP14 gene

10/294 NCBI SNPs in FKBP14 are shown (see all 294)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs133111401,2	C	--	29933000(+)	tatggG/Tatata	3	--	ut31 nc-transcript-variant		1		NA	2
rs1889655031,2		--	30049786(+)	ATTTCG/TTTTAA	3	--	ds5001		0	--	--	--	--
rs1499660001,2		--	30049821(+)	TTTACA/GCAGTA	3	--	ds5001		0	--	--	--	--
rs1930991401,2		--	30049868(+)	AAACCA/CTAAAC	3	--	ds5001		0	--	--	--	--
rs1828871921,2		--	30049931(+)	AAAAAC/TACTTT	3	--	ds5001		0	--	--	--	--
rs1875267311,2		--	30049967(+)	ACTATC/TATGCT	3	--	ds5001		0	--	--	--	--
rs1916889031,2		--	30049972(+)	CATGCA/TAAAGG	3	--	ds5001		0	--	--	--	--
rs1842461401,2		--	30050152(+)	GAAAAC/TCAGTA	3	--	ds5001		0	--	--	--	--
rs1429370981,2	C,	--	30050243(+)	TCACA-/ATATAGT	3	--	nc-transcript-variantut31		0	--	--	--	--
rs1867390541,2		--	30050446(+)	TTGGTG/TTTTGA	3	--	nc-transcript-variantut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for FKBP14 (30050203 - 30066300 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for FKBP14: --
Human Gene Mutation Database (HGMD): FKBP14

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FKBP14

DNA2.0 Custom Variant and Variant Library Synthesis for FKBP14

Disorders / Diseases
for FKBP14 gene

Publications
for FKBP14 gene

PubMed articles for FKBP14 gene, integrated from 9 sources (see all 15): (articles sorted by number of sources associating them with FKBP14)

Utopia: connect your pdf to the dynamic world of online information

1. Mutations in FKBP14 cause a variant of Ehlers-Danlos syndrome with progressive kyphoscoliosis, myopathy, and hearing loss. (PubMed id 22265013)^{1, 2} Baumann M.... Fauth C. (2012)
2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
6. Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family. (PubMed id 12036304)^{1, 3} Patterson C.E....Davis E.C. (2002)
7. Genome-wide association study of circulating estradiol , testosterone, and sex hormone-binding globulin in postmenopausal women. (PubMed id 22675492)¹ Prescott J....De Vivo I. (2012)
8. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)
9. Analysis of interaction partners of H4 histone by a n ew proteomics approach. (PubMed id 19862764)¹ Saade E....Ogryzko V. (2009)
10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)

External Searches for FKBP14 gene

Genome Databases showing FKBP14 gene

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Products
for FKBP14 gene