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FKBP14 Gene

protein-coding   GIFtS: 58
GCID: GC07M030050

FK506 Binding Protein 14, 22 KDa

(Previous name: FK506 binding protein 14 (22 kDa))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FK506 Binding Protein 14, 22 KDa1 2     FK506 Binding Protein 14 (22 KDa)1
22 KDa FK506-Binding Protein2 3     IPBP122
22 KDa FKBP2 3     Peptidyl-Prolyl Cis-Trans Isomerase FKBP142
FKBP-222 3     rotamase2
FKBP222 3     EC 5.2.1.83
FK506-Binding Protein 142 3     FKBP-143
PPIase FKBP142 3     Rotamase3
EDSKMH2 5     

External Ids:    HGNC: 186251   Entrez Gene: 550332   Ensembl: ENSG000001060807   OMIM: 6145055   UniProtKB: Q9NWM83   

Export aliases for FKBP14 gene to outside databases

Previous GC identifers: GC07M029695 GC07M029795 GC07M029826 GC07M030019


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FKBP14 Gene:
The protein encoded by this gene is a member of the FK506-binding protein family of peptidyl-prolyl cis-trans
isomerases. The encoded protein is found in the lumen of the endoplasmic reticulum, where it is thought to
accelerate protein folding. Defects in this gene are a cause of a type of Ehlers-Danlos syndrome (EDS). Both a
protein-coding variant and noncoding variants are transcribed from this gene. (provided by RefSeq, Mar 2012)

GeneCards Summary for FKBP14 Gene:
FKBP14 (FK506 binding protein 14, 22 kDa) is a protein-coding gene. Diseases associated with FKBP14 include ehlers-danlos syndrome with progressive kyphoscoliosis, myopathy, and hearing loss, and ehlers-danlos syndrome type via. GO annotations related to this gene include FK506 binding and calcium ion binding. An important paralog of this gene is FKBP11.

UniProtKB/Swiss-Prot: FKB14_HUMAN, Q9NWM8
Function: PPIases accelerate the folding of proteins during protein synthesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the FKBP14 gene promoter:
         AML1a   HSF1 (long)   CBF-C   HNF-1A   CBF-B   CBF-A   HNF-1   HSF1short   CP1A   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFKBP14 promoter sequence
   Search Chromatin IP Primers for FKBP14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FKBP14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14.3   Ensembl cytogenetic band:  7p14.3   HGNC cytogenetic band: 7p15

FKBP14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FKBP14 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M030050:  view genomic region     (about GC identifiers)

Start:
30,050,203 bp from pter      End:
30,066,300 bp from pter
Size:
16,098 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 30,102,713-30,116,097     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FKB14_HUMAN, Q9NWM8 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase FKBP14 precursor  
Size: 211 amino acids; 24172 Da
2 PDB 3D structures from and Proteopedia for FKBP14:
4DIP (3D)        4MSP (3D)    

Explore the universe of human proteins at neXtProt for FKBP14: NX_Q9NWM8

Explore proteomics data for FKBP14 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn176

  • See FKBP14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060416.1  
    ENSEMBL proteins: 
     ENSP00000222803   ENSP00000406270   ENSP00000403279  
    Reactome Protein details: Q9NWM8

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    5 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR023566 PPIase_FKBP
     IPR018247 EF_Hand_1_Ca_BS
     IPR001179 PPIase_FKBP_dom

    Graphical View of Domain Structure for InterPro Entry Q9NWM8

    ProtoNet protein and cluster: Q9NWM8

    UniProtKB/Swiss-Prot: FKB14_HUMAN, Q9NWM8
    Similarity: Contains 2 EF-hand domains
    Similarity: Contains 1 PPIase FKBP-type domain


    FKBP14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FKB14_HUMAN, Q9NWM8
    Function: PPIases accelerate the folding of proteins during protein synthesis
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)

         Enzyme Number (IUBMB): EC 5.2.1.81

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity IBA--
    GO:0005509calcium ion binding IEA--
    GO:0005528FK506 binding IBA--
         
    FKBP14 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FKBP14:
     Increased G1 DNA content 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target FKBP14:
    hsa-mir-26b-5p (MIRT030076), hsa-mir-124-3p (MIRT023029), hsa-mir-335-5p (MIRT018653)

    Block miRNA regulation of human, mouse, rat FKBP14 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FKBP14 (see all 12):
    hsa-miR-3671 hsa-miR-3163 hsa-miR-607 hsa-miR-520d-5p hsa-miR-3647-3p hsa-miR-1305 hsa-miR-4310 hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidFKBP14 3' UTR sequence
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBP14


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FKB14_HUMAN, Q9NWM8: Endoplasmic reticulum lumen
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular3
    cytosol2
    golgi apparatus2
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0016020membrane IBA--

    FKBP14 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FKBP14 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Unfolded Protein Response
    Unfolded Protein Response0.61
    Activation of Chaperone Genes by XBP1(S)0.59
    Activation of Chaperones by IRE1alpha0.61
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for FKBP14
        XBP1(S) activates chaperone genes



    FKBP14 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FKBP14
    Interactions:

        Search GeneGlobe Interaction Network for FKBP14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FKBP14 (Q9NWM82, 3 ENSP000002228034) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=2 STRING: ENSP00000352980
    HIST1H4LP628053, ENSP000003482584I2D: score=2 STRING: ENSP00000348258
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000413protein peptidyl-prolyl isomerization IBA--
    GO:0006457protein folding IEA--
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0018208peptidyl-proline modification IBA--
    GO:0030968endoplasmic reticulum unfolded protein response TAS--

    FKBP14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FKBP14 (FKB14)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FKBP14 gene: 
    NM_017946.3  

    Unigene Cluster for FKBP14:

    FK506 binding protein 14, 22 kDa
    Hs.390838  [show with all ESTs]
    Unigene Representative Sequence: NR_046478
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222803(uc003tal.1 uc010kvq.1) ENST00000419018 ENST00000412494
    ENST00000479939
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FKBP14 (see all 12):
    hsa-miR-3671 hsa-miR-3163 hsa-miR-607 hsa-miR-520d-5p hsa-miR-3647-3p hsa-miR-1305 hsa-miR-4310 hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidFKBP14 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK000738.1 AK309552.1 AY358643.1 BC005206.1 JQ797475.1 NR_046478.1 NR_046479.1 

    9 DOTS entries:

    DT.406555  DT.106790  DT.121094647  DT.121094591  DT.100746729  DT.95264410  DT.107806  DT.121094541 
    DT.95264407 

    Selected AceView cDNA sequences (see all 108):

    AA733022 AA446931 CA445251 NM_017946 N28018 BC005206 BQ776505 BM995749 
    BP372815 AA347452 BQ010262 CA419538 BX098436 AA443355 BX104510 AI752977 
    CB116619 AA279599 BQ220039 CA420944 CA422933 AA452666 AI687408 AI244157 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FKBP14    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
    SP1:                          -                           
    SP2:                          -     -                     
    SP3:                                                      


    ECgene alternative splicing isoforms for FKBP14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FKBP14 expression in normal human tissues (normalized intensities)      FKBP14 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCTTTGGT
    FKBP14 Expression
    About this image


    FKBP14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)
             Rib
    FKBP14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FKBP14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.390838
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FKBP14 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fkbp141 , 5 FK506 binding protein 141, 5 87.68(n)1
    92.89(a)1
      6 (27.01 cM)5
    2319971  NM_153573.11  NP_705801.11 
     545776045 
    chicken
    (Gallus gallus)
    Aves FKBP141 FK506 binding protein 14, 22 kDa 74.24(n)
    81.64(a)
      420636  XM_418735.4  XP_418735.1 
    lizard
    (Anolis carolinensis)
    Reptilia FKBP146
    FK506 binding protein 14, 22 kDa
    80(a)
    1 ↔ 1
    6(35488243-35499218)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.68022 Xenopus laevis transcribed sequence with moderate similarity more 74.67(n)    CF522423.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd36a032 wufd36a03 75.49(n)   325860  CF997563.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Fkbp131 , 3 FK506 binding3
    Fkbp131
    45(a)3
    52.64(n)1
    45.54(a)1
      374491  NM_001259519.11  NP_001246448.11 
    worm
    (Caenorhabditis elegans)
    Secernentea fkb-76
    Protein FKB-7 (fkb-7) mRNA, complete cds
    20(a)
    1 → many
    I(10667955-10671016) WBGene00001432
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FPR26
    Membrane-bound peptidyl-prolyl cis-trans isomerase...
    37(a)
    1 → many
    IV(1480425-1480832) YDR519W


    ENSEMBL Gene Tree for FKBP14 (if available)
    TreeFam Gene Tree for FKBP14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for FKBP14 gene
    FKBP112  FKBP22  FKBP102  FKBP92  FKBP72  
    11 SIMAP similar genes for FKBP14 using alignment to 3 protein entries:     FKB14_HUMAN (see all proteins):
    FKBP7    FKBP2    FKBP1C    FKBP10    FKBP12-Exip2    FKBP1A
    FKBP1B    DKFZp666D193    FKBP11    FKBP9    FKBP4

    FKBP14 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FKBP14 (see all 366)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1889655031,2
    --30027953(+) ATTTCG/TTTTAA 3 -- ds50010--------
    rs1499660001,2
    --30027988(+) TTTACA/GCAGTA 3 -- ds50010--------
    rs1930991401,2
    C--30028035(+) AAACCA/CTAAAC 3 -- ds50010--------
    rs1828871921,2
    --30028098(+) AAAAAC/TACTTT 3 -- ds50010--------
    rs1875267311,2
    --30028134(+) ACTATC/TATGCT 3 -- ds50010--------
    rs1916889031,2
    --30028139(+) CATGCA/TAAAGG 3 -- ds50010--------
    rs793514821,2
    F--30028197(+) TTTCTT/CACAAA 3 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1842461401,2
    --30028319(+) GAAAAC/TCAGTA 3 -- ds50010--------
    rs1429370981,2
    C--30028410(+) TCACA-/ATATAGT 3 -- ut31 nc-transcript-variant0--------
    rs1867390541,2
    --30028613(+) TTGGTG/TTTTGA 3 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for FKBP14 (30050203 - 30066300 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FKBP14: --
    Human Gene Mutation Database (HGMD): FKBP14
    Locus Specific Mutation Databases (LSDB): FKBP14

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614505   
    OMIM disorders: 614557  
    UniProtKB/Swiss-Prot: FKB14_HUMAN, Q9NWM8
  • Ehlers-Danlos syndrome, with progressive kyphoscoliosis, myopathy, and hearing loss (EDSKMH)
    [MIM:614557]: A syndrome with features of Ehlers-Danlos syndrome types VIA and VIB on the one hand, and the
    collagen VI-related congenital myopathies Ullrich congenital muscular dystrophy and Bethlem myopathy on the other
    hand. Clinically, this disorder is characterized by the following features: severe generalized hypotonia at birth
    with marked muscle weakness that improve in infancy; early-onset progressive kyphoscoliosis; joint hypermobility
    without contractures; hyperelastic skin with follicular hyperkeratosis, easy bruising, and occasional abnormal
    scarring; myopathy; hearing impairment, which is predominantly sensorineural; normal ratio of lysyl pyridinoline
    to hydroxylysyl pyridinoline (LP/HP) in urine. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 14 diseases for FKBP14:    About MalaCards
    ehlers-danlos syndrome with progressive kyphoscoliosis, myopathy, and hearing loss    ehlers-danlos syndrome type via    ullrich congenital muscular dystrophy    bethlem myopathy
    ehlers-danlos syndrome    congenital muscular dystrophy    hypotonia    muscular dystrophy
    myopathy    glioblastoma multiforme    malaria    multiple myeloma
    myeloma    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for FKBP14:
    Ullrich congenital muscular dystrophy

    FKBP14 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FKBP14

    Export disorders for FKBP14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FKBP14 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with FKBP14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in FKBP14 cause a variant of Ehlers-Danlos syndrome with progressive kyphoscoliosis, myopathy, and hearing loss. (PubMed id 22265013)1, 2 Baumann M.... Fauth C. (Am. J. Hum. Genet. 2012)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family. (PubMed id 12036304)1, 3 Patterson C.E....Davis E.C. (Genomics 2002)
    7. Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women. (PubMed id 22675492)1 Prescott J....De Vivo I. (PLoS ONE 2012)
    8. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    9. Analysis of interaction partners of H4 histone by a new proteomics approach. (PubMed id 19862764)1 Saade E....Ogryzko V. (Proteomics 2009)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55033 HGNC: 18625 AceView: FKBP14 Ensembl:ENSG00000106080 euGenes: HUgn55033
    ECgene: FKBP14 H-InvDB: FKBP14

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FKBP14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FKBP14 gene:
    Search GeneIP for patents involving FKBP14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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