Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FKBP11 Gene

protein-coding   GIFtS: 46
GCID: GC12M049315

FK506 binding protein 11, 19 kDa

(Previous name: FK506 binding protein 11 (19 kDa) )
  Search for FKBP11
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FKBP11    

Aliases
for FKBP11 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
FK506 Binding Protein 11, 19 KDa1 2     PPIase FKBP112 3
FKBP191 2 3     FK506 Binding Protein 11 (19 KDa)1
19 KDa FK506-Binding Protein2 3     Peptidyl-Prolyl Cis-Trans Isomerase FKBP112
19 KDa FKBP2 3     Rotamase3
FKBP-112 3     EC 5.2.1.83
FKBP-192 3     Rotamase3
FK506-Binding Protein 112 3     

External Ids:    HGNC: 186241   Entrez Gene: 513032   Ensembl: ENSG000001342857   OMIM: 6105715   UniProtKB: Q9NYL43   

Export aliases for FKBP11 gene to outside databases

Previous GC identifers: GC12P049273 GC12M049032 GC12M047602 GC12M046347


Summaries
for FKBP11 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FKBP11:
FKBP11 belongs to the FKBP family of peptidyl-prolyl cis/trans isomerases, which catalyze the folding of
proline-containing polypeptides. The peptidyl-prolyl isomerase activity of FKBP proteins is inhibited by the
immunosuppressant compounds FK506 and rapamycin (Rulten et al., 2006 (PubMed 16596453)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: FKB11_HUMAN, Q9NYL4
Function: PPIases accelerate the folding of proteins during protein synthesis




Genomic Views
for FKBP11 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FKBP11 gene promoter:
         PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FKBP11 promoter sequence
   Search SABiosciences Chromatin IP Primers for FKBP11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FKBP11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.12   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13.12

FKBP11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FKBP11 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M049315:  view genomic region     (about GC identifiers)

Start:
 49,315,301 bp from pter      End:
 49,320,257 bp from pter
Size:
 4,957 bases      Orientation:
 minus strand

Proteins
for FKBP11 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FKB11_HUMAN, Q9NYL4 (See protein sequence)
Recommended Name: Peptidyl-prolyl cis-trans isomerase FKBP11 precursor  
Size: 201 amino acids; 22180 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: B4DWB7
Alternative splicing: 2 isoforms:  Q9NYL4-1   Q9NYL4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FKBP11: NX_Q9NYL4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NYL4

    • FKBP11 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001137253.1  NP_001137254.1  NP_057678.1  

    ENSEMBL proteins: 
     ENSP00000412403   ENSP00000449751   ENSP00000447411   ENSP00000256680   ENSP00000447911  
     ENSP00000396874   ENSP00000448805  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: FKBP11
    OriGene Custom Protein Services for FKBP11 
    GenScript Custom Purified and Recombinant Proteins Services for FKBP11
    Novus Biologicals FKBP11 Protein
    Novus Biologicals FKBP11 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FKBP11

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane IBA--
    GO:0016021integral to membrane IEA--


    FKBP11 for ontologies           About GeneDecksing



    FKBP11 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FKBP11 
    GenScript Custom Superior Antibodies Services for FKBP11
    Novus Biologicals FKBP11 Antibodies
    Search for Antibodies for FKBP11 at Abcam  
    Uscn Antibodies for FKBP11
    Search ThermoFisher Antibodies for FKBP11

    Assay Products for FKBP11: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FKBP11
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for FKBP11

    Protein Domains /
    Families
    for FKBP11 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FKBP11 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR023566 PPIase_FKBP
     IPR001179 PPIase_FKBP_dom

    Graphical View of Domain Structure for InterPro Entry Q9NYL4

    ProtoNet protein and cluster: Q9NYL4

    UniProtKB/Swiss-Prot: FKB11_HUMAN, Q9NYL4
    Similarity: Belongs to the FKBP-type PPIase family
    Similarity: Contains 1 PPIase FKBP-type domain


    Function
    for FKBP11 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FKB11_HUMAN, Q9NYL4
    Function: PPIases accelerate the folding of proteins during protein synthesis
    Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)

    Enzyme Number (IUBMB): EC 5.2.1.81

    miRNA
    Products:            		 OriGene 3'-UTR Clone: FKBP11
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FKBP11
    1 QIAGEN miScript miRNA Assays for microRNA that regulate FKBP11:
    hsa-miR-943
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FKBP11 (see all 7)
    OriGene shRNA RFP: FKBP11
    OriGene siRNA: FKBP11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FKBP11

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for FKBP11

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP11 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP11 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): FKBP11 (NM_001143781)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FKBP11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FKBP11 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for FKBP11
    Search LifeMap BioReagents cell lines for FKBP11

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBP11

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003755peptidyl-prolyl cis-trans isomerase activity IBA--
    GO:0005528FK506 binding IBA--


    FKBP11 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for FKBP11:
     Increased circadian rhythm amp  Synthetic lethal with imatinib 

    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Fkbp11):
     immune system  skeleton 

    FKBP11 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FKBP11 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FKBP11

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for FKBP11 (ENSP000002566804) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RELAENSP000003842734STRING: ENSP00000384273
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000413protein peptidyl-prolyl isomerization IBA--
    GO:0006457protein folding IEA--
    GO:0018208peptidyl-proline modification IBA--


    FKBP11 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FKBP11 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FKBP11
    Search CenterWatch for drugs/clinical trials and news about FKBP11 / FKB11 

    Transcripts
    for FKBP11 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FKBP11 gene (3 alternative transcripts): 
    NM_001143781.1  NM_001143782.1  NM_016594.2  

    Unigene Cluster for FKBP11:

    FK506 binding protein 11, 19 kDa
    Hs.655103  [show with all ESTs]
    Unigene Representative Sequence: AK094876
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000553027 ENST00000551094 ENST00000444214(uc010sma.2) ENST00000550765(uc001rsp.3)
    ENST00000546847 ENST00000551694(uc001rsq.4) ENST00000256680 ENST00000552878
    ENST00000453172(uc010smb.1) ENST00000546671 ENST00000547789 ENST00000549084
    ENST00000551807

    miRNA
    Products:             		 OriGene 3'-UTR Clone: FKBP11
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FKBP11
    1 QIAGEN miScript miRNA Assays for microRNA that regulate FKBP11:
    hsa-miR-943
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FKBP11 (see all 7)
    OriGene shRNA RFP: FKBP11
    OriGene siRNA: FKBP11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FKBP11
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP11 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP11 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): FKBP11 (NM_001143781)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FKBP11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FKBP11 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FKBP11
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FKBP11
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FKBP11
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FKBP11

    Additional cDNA sequence: 

    AF238079.1 AK094876.1 AK301455.1 AY358998.1 BC027973.1 

    14 DOTS entries:

    DT.445607  DT.100774159  DT.121151546  DT.91657941  DT.100774160  DT.121151625  DT.92421563  DT.121151677 
    DT.440490  DT.91787211  DT.102843302  DT.121151597  DT.87001727  DT.99962012 

    6 AceView cDNA sequences:

    AK094876 AY358998 AF238079 NM_016594 BC048292 BC027973 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FKBP11 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8
    SP1:        -     -           -                 -     -                     
    SP2:        -     -           -                 -     -           -         
    SP3:        -     -           -                                             
    SP4:                          -                                             
    SP5:                                                                        


    ECgene alternative splicing isoforms for FKBP11

    Expression
    for FKBP11 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FKBP11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGCCAGCCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FKBP11 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneThoracic RibBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)

    See FKBP11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FKBP11

    SOURCE GeneReport for Unigene cluster: Hs.655103
        SABiosciences Custom PCR Arrays for FKBP11
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FKBP11
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FKBP11
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FKBP11
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FKBP11
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBP11

    Orthologs
    for FKBP11 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FKBP11 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia FKBP116
    		 --
    		 66(a)
    		 1 ↔ 1
    		 2(94169570-94179498)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.239562 Xenopus laevis transcribed sequence with weak similarity more 72.88(n)    BX845650.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii fkbp111 FK506 binding protein 11 57.35(n)
    52.69(a)    		   368823  XM_003198749.1  XP_003198797.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea fkb-36
    fkb-46
    (see all 3)    		 FK506-Binding protein family member (fkb-4)
    (see all 3)    		 15(a)
    13(a)
    (see all 3)    		 1 ↔ many
    1 ↔ many
    (see all 3)    		 V(7225351-7226296)
    V(12785136-12787087)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATFKBP136
    FKBP16-26
    		 FKBP-type peptidyl-prolyl cis-trans isomerase 3
    putative FKBP-type peptidyl-prolyl cis-trans isome...
    		 17(a)
    17(a)
    		 possible ortholog
    possible ortholog
    		 5(18530880-18532337)
    4(18427039-18428412)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 peptidyl-prolyl cis-trans isomerase, FKBP-type, pu...
    peptidyl-prolyl cis-trans isomerase, FKBP-type, pu...
    		 17(a)
    15(a)
    		 possible ortholog
    possible ortholog
    		 6(27401365-27402771)
    2(31585352-31587283)


    ENSEMBL Gene Tree for FKBP11 (if available)
    TreeFam Gene Tree for FKBP11 (if available) 

    Paralogs
    for FKBP11 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FKBP11 gene
    FKBP22  FKBP142  FKBP102  FKBP72  FKBP92  
    18/25 SIMAP similar genes for FKBP11 using alignment to 7 protein entries:     FKB11_HUMAN (see all proteins) (see all similar genes):
    X-linked retinopathy protein    RHBG    ATL2    KIAA0101    SNRPF    COQ5
    SH2B3    LOC100996300    pp12301    KIAA1651    TUBA1C    GALK2
    GEMIN6    FKBP9    DKFZp666D193    FKBP10    NEK4    FKBP2

    FKBP11 for paralogs           About GeneDecksing



    Genomic Variants
    for FKBP11 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/103 NCBI SNPs in FKBP11 are shown (see all 103)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1385661101,2
    		C--49315301(+) TTTTT-/TGAGAA 3 -- ut31 ds50010--------
    rs1827660351,2
    		--49315370(+) TCTTTA/GTATCT 3 -- ds5001 int10--------
    rs1866292901,2
    		--49315417(+) CTAGGA/CACACT 3 -- int1 ds50010--------
    rs784601991,2
    		--49315422(+) AACACC/TGTGGT 3 -- ds5001 int10--------
    rs1901450391,2
    		--49315518(+) AGAGCC/TAAAAC 3 -- ds5001 int10--------
    rs1385874421,2
    		--49315656(+) AGATGC/TAATTC 3 -- ds5001 int10--------
    rs2010814251,2
    		--49315733(+) ATGAAA/GAATGC 3 -- ds5001 int10--------
    rs1823809521,2
    		--49315790(+) GTTTCA/GTTTCT 5 R * int1 stg10--------
    rs786550451,2
    		C,--49315816(+) TTTTGG/TAGACT 5 Y S mis1 int10--------
    rs1483025471,2
    		C,F,--49315821(+) GAGACT/CTTGGG 5 /K syn1 int11Minor allele frequency- C:0.00NA 4518

    HapMap Linkage Disequilibrium report for FKBP11 (49315301 - 49320257 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for FKBP11
         1 CNV: 4777

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FKBP11
    DNA2.0 Custom Variant and Variant Library Synthesis for FKBP11

    Disorders / Diseases
    for FKBP11 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FKBP11 for disorders           About MalaCards

    FKBP11 for disorders           About GeneDecksing

    OMIM gene information: 610571    OMIM disorders: --


    Export disorders for FKBP11 gene to outside databases

    Publications
    for FKBP11 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FKBP11 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FKBP11)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human FK506-binding proteins: characterization of human FKBP19. (PubMed id 16596453)1, 3, 9 Rulten S.L....Kay J.E. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family. (PubMed id 12036304)1, 3 Patterson C.E....Davis E.C. (2002)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    6. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)2 Clark H.F.... Gray A.M. (2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    External Searches for FKBP11 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FKBP11 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51303 HGNC: 18624 AceView: FKBP11 Ensembl:ENSG00000134285 euGenes: HUgn51303
    ECgene: FKBP11 H-InvDB: FKBP11

    Other Databases showing FKBP11 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FKBP11 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FKBP11 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FKBP11 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FKBP11 gene:
    Search GeneIP for patents involving FKBP11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for FKBP11 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for FKBP11  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FKBP11   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FKBP11  
     OriGene Protein Over-expression Lysate for FKBP11   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for FKBP11   OriGene 3'-UTR Clone for FKBP11  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP11   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FKBP11  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FKBP11   OriGene Custom Protein Services for FKBP11  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FKBP11
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FKBP11
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FKBP11
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FKBP11
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FKBP11
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FKBP11
     GenScript Custom Purified and Recombinant Proteins Services for FKBP11 GenScript cDNA clones with any tag delivered in your preferred vector for FKBP11
     GenScript Custom Assay Services for FKBP11 GenScript Custom Superior Antibodies Services for FKBP11
     GenScript Custom overexpressing Cell Line Services for FKBP11 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FKBP11 promoter
     Search Chromatin IP Primers for FKBP11
     RT2 qPCR Primer Assay in human, mouse, rat FKBP11
     GNC Network for FKBP11
     SABiosciences Custom PCR Arrays for FKBP11
     Search Tocris compounds for FKBP11
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FKBP11 antibodies
     FKBP11 proteins
     FKBP11 lysates
     Search for Antibodies for FKBP11 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for FKBP11
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     FKBP11 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for FKBP11
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FKBP11
     Browse SwitchGear 3'UTR luciferase reporter plasmids for FKBP11
     SwitchGear Promoter luciferase reporter plasmids for FKBP11
     Search ThermoFisher Antibodies for FKBP11
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FKBP11
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      FKBP11 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4