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Aliases for FKBP11 Gene

Subcategory (RNA class) for FKBP11 Gene

antisense

Aliases for FKBP11 Gene

  • FK506 Binding Protein 11 2 3 5
  • FK506 Binding Protein 11, 19 KDa 2 3
  • 19 KDa FK506-Binding Protein 3 4
  • FK506-Binding Protein 11 3 4
  • PPIase FKBP11 3 4
  • 19 KDa FKBP 3 4
  • Rotamase 3 4
  • FKBP-11 3 4
  • FKBP-19 3 4
  • FKBP19 3 4
  • FK506 Binding Protein 11 (19 KDa) 2
  • EC 5.2.1.8 4

External Ids for FKBP11 Gene

ORGUL Members for FKBP11 Gene

Previous GeneCards Identifiers for FKBP11 Gene

  • GC12P049273
  • GC12M049032
  • GC12M047602
  • GC12M049315
  • GC12M046347

Summaries for FKBP11 Gene

Entrez Gene Summary for FKBP11 Gene

  • FKBP11 belongs to the FKBP family of peptidyl-prolyl cis/trans isomerases, which catalyze the folding of proline-containing polypeptides. The peptidyl-prolyl isomerase activity of FKBP proteins is inhibited by the immunosuppressant compounds FK506 and rapamycin (Rulten et al., 2006 [PubMed 16596453]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FKBP11 Gene

FKBP11 (FK506 Binding Protein 11) is a Protein Coding gene, and is affiliated with the antisense RNA class. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and FK506 binding. An important paralog of this gene is FKBP7.

UniProtKB/Swiss-Prot for FKBP11 Gene

  • PPIases accelerate the folding of proteins during protein synthesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBP11 Gene

Genomics for FKBP11 Gene

Regulatory Elements for FKBP11 Gene

Enhancers for FKBP11 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FKBP11 on UCSC Golden Path with GeneCards custom track

Promoters for FKBP11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FKBP11 on UCSC Golden Path with GeneCards custom track

Genomic Location for FKBP11 Gene

Chromosome:
12
Start:
48,921,518 bp from pter
End:
48,926,474 bp from pter
Size:
4,957 bases
Orientation:
Minus strand

Genomic View for FKBP11 Gene

Genes around FKBP11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FKBP11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FKBP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP11 Gene

Proteins for FKBP11 Gene

  • Protein details for FKBP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYL4-FKB11_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP11
    Protein Accession:
    Q9NYL4
    Secondary Accessions:
    • B4DWB7

    Protein attributes for FKBP11 Gene

    Size:
    201 amino acids
    Molecular mass:
    22180 Da
    Quaternary structure:
    • Interacts with IFITM5.

    Alternative splice isoforms for FKBP11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FKBP11 Gene

Proteomics data for FKBP11 Gene at MOPED

Post-translational modifications for FKBP11 Gene

  • Glycosylation at Thr 76
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FKBP11 Gene

Domains & Families for FKBP11 Gene

Gene Families for FKBP11 Gene

Protein Domains for FKBP11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FKBP11 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYL4

UniProtKB/Swiss-Prot:

FKB11_HUMAN :
  • Contains 1 PPIase FKBP-type domain.
  • Belongs to the FKBP-type PPIase family.
Domain:
  • Contains 1 PPIase FKBP-type domain.
Family:
  • Belongs to the FKBP-type PPIase family.
genes like me logo Genes that share domains with FKBP11: view

Function for FKBP11 Gene

Molecular function for FKBP11 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins during protein synthesis.

Enzyme Numbers (IUBMB) for FKBP11 Gene

genes like me logo Genes that share phenotypes with FKBP11: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FKBP11

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FKBP11 Gene

Localization for FKBP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP11 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FKBP11 Gene COMPARTMENTS Subcellular localization image for FKBP11 gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 3
cytoskeleton 2
cytosol 2
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FKBP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FKBP11: view

Pathways & Interactions for FKBP11 Gene

SuperPathways for FKBP11 Gene

No Data Available

Interacting Proteins for FKBP11 Gene

Gene Ontology (GO) - Biological Process for FKBP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0061077 chaperone-mediated protein folding IBA --
genes like me logo Genes that share ontologies with FKBP11: view

No data available for Pathways by source and SIGNOR curated interactions for FKBP11 Gene

Drugs & Compounds for FKBP11 Gene

No Compound Related Data Available

Transcripts for FKBP11 Gene

mRNA/cDNA for FKBP11 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FKBP11 Gene

FK506 binding protein 11, 19 kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP11 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: -
SP5:
SP6: -

Relevant External Links for FKBP11 Gene

GeneLoc Exon Structure for
FKBP11
ECgene alternative splicing isoforms for
FKBP11

Expression for FKBP11 Gene

mRNA expression in normal human tissues for FKBP11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FKBP11 Gene

This gene is overexpressed in Pancreas (x8.3).

Protein differential expression in normal tissues from HIPED for FKBP11 Gene

This gene is overexpressed in Pancreas (13.5), Islet of Langerhans (9.3), Skin (8.2), and Salivary gland (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FKBP11 Gene



SOURCE GeneReport for Unigene cluster for FKBP11 Gene Hs.655103

genes like me logo Genes that share expression patterns with FKBP11: view

Protein tissue co-expression partners for FKBP11 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FKBP11 Gene

Orthologs for FKBP11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FKBP11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FKBP11 35
  • 91.58 (n)
  • 90.66 (a)
FKBP11 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FKBP11 35
  • 91.99 (n)
  • 93.44 (a)
FKBP11 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fkbp11 35
  • 87.73 (n)
  • 91.76 (a)
Fkbp11 16
Fkbp11 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FKBP11 35
  • 100 (n)
  • 100 (a)
FKBP11 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fkbp11 35
  • 89.19 (n)
  • 90.11 (a)
lizard
(Anolis carolinensis)
Reptilia FKBP11 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fkbp11 35
  • 63.73 (n)
  • 61.03 (a)
Str.15739 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.23956 35
zebrafish
(Danio rerio)
Actinopterygii fkbp11 35
  • 57.77 (n)
  • 52.84 (a)
fkbp11 36
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14715 36
  • 33 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea fkb-1 36
  • 39 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPR2 36
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for FKBP11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FKBP11 Gene

ENSEMBL:
Gene Tree for FKBP11 (if available)
TreeFam:
Gene Tree for FKBP11 (if available)

Paralogs for FKBP11 Gene

Paralogs for FKBP11 Gene

genes like me logo Genes that share paralogs with FKBP11: view

Variants for FKBP11 Gene

Sequence variations from dbSNP and Humsavar for FKBP11 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs7134686 -- 48,926,543(+) tttga(A/G)gggga upstream-variant-2KB
rs10875895 -- 48,922,959(+) GCCTG(A/G)CCAAC intron-variant, downstream-variant-500B
rs12829682 -- 48,925,253(+) CACCC(A/C)ACAAG intron-variant, upstream-variant-2KB
rs2272312 -- 48,925,487(+) GCAGC(C/T)AGGAC upstream-variant-2KB, utr-variant-5-prime
rs2293448 -- 48,924,069(+) AGGCT(C/T)TGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FKBP11 Gene

Variant ID Type Subtype PubMed ID
nsv832404 CNV Gain 17160897

Variation tolerance for FKBP11 Gene

Residual Variation Intolerance Score: 32.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FKBP11 Gene

HapMap Linkage Disequilibrium report
FKBP11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FKBP11 Gene

Disorders for FKBP11 Gene

Relevant External Links for FKBP11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FKBP11

No disorders were found for FKBP11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FKBP11 Gene

Publications for FKBP11 Gene

  1. The human FK506-binding proteins: characterization of human FKBP19. (PMID: 16596453) Rulten S.L. … Kay J.E. (Mamm. Genome 2006) 2 3 23 67
  2. Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family. (PMID: 12036304) Patterson C.E. … Davis E.C. (Genomics 2002) 2 3
  3. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  4. Identification of FKBP11 as a biomarker for hepatocellular carcinoma. (PMID: 23749938) Lin I.Y. … Chen Y.M. (Anticancer Res. 2013) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for FKBP11 Gene

Sources for FKBP11 Gene

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