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Aliases for FKBP11 Gene

Subcategory (RNA class) for FKBP11 Gene

antisense

Aliases for FKBP11 Gene

  • FK506 Binding Protein 11, 19 KDa 2 3
  • FKBP19 3 4 6
  • 19 KDa FK506-Binding Protein 3 4
  • FK506-Binding Protein 11 3 4
  • PPIase FKBP11 3 4
  • 19 KDa FKBP 3 4
  • Rotamase 3 4
  • FKBP-11 3 4
  • FKBP-19 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase FKBP11 3
  • FK506 Binding Protein 11 (19 KDa) 2
  • EC 5.2.1.8 4

External Ids for FKBP11 Gene

ORGUL Members for FKBP11 Gene

Summaries for FKBP11 Gene

Entrez Gene Summary for FKBP11 Gene

  • FKBP11 belongs to the FKBP family of peptidyl-prolyl cis/trans isomerases, which catalyze the folding of proline-containing polypeptides. The peptidyl-prolyl isomerase activity of FKBP proteins is inhibited by the immunosuppressant compounds FK506 and rapamycin (Rulten et al., 2006 [PubMed 16596453]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FKBP11 Gene

FKBP11 (FK506 Binding Protein 11, 19 KDa) is a Protein Coding gene, and belongs to antisense RNA class. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and FK506 binding. An important paralog of this gene is FKBP7.

UniProtKB/Swiss-Prot for FKBP11 Gene

  • PPIases accelerate the folding of proteins during protein synthesis

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBP11 Gene

Genomics for FKBP11 Gene

Genomic Location for FKBP11 Gene

Start:
48,921,518 bp from pter
End:
48,926,474 bp from pter
Size:
4,957 bases
Orientation:
Minus strand

Genomic View for FKBP11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FKBP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP11 Gene

Regulatory Elements for FKBP11 Gene

Proteins for FKBP11 Gene

  • Protein details for FKBP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYL4-FKB11_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP11
    Protein Accession:
    Q9NYL4
    Secondary Accessions:
    • B4DWB7

    Protein attributes for FKBP11 Gene

    Size:
    201 amino acids
    Molecular mass:
    22180 Da
    Quaternary structure:
    • Interacts with IFITM5.

    Alternative splice isoforms for FKBP11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FKBP11 Gene

Proteomics data for FKBP11 Gene at MOPED

Post-translational modifications for FKBP11 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Thr76

No data available for DME Specific Peptides for FKBP11 Gene

Domains for FKBP11 Gene

Protein Domains for FKBP11 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

FKB11_HUMAN
Domain:
  • Contains 1 PPIase FKBP-type domain.:
    • Q9NYL4
Family:
  • Belongs to the FKBP-type PPIase family.:
    • Q9NYL4
genes like me logo Genes that share domains with FKBP11: view

No data available for Gene Families for FKBP11 Gene

Function for FKBP11 Gene

Molecular function for FKBP11 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Peptidylproline (omega=180) = peptidylproline (omega=0)
UniProtKB/Swiss-Prot Function: PPIases accelerate the folding of proteins during protein synthesis

Enzyme Numbers (IUBMB) for FKBP11 Gene

Gene Ontology (GO) - Molecular Function for FKBP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0005528 FK506 binding IBA --
genes like me logo Genes that share ontologies with FKBP11: view
genes like me logo Genes that share phenotypes with FKBP11: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FKBP11 Gene

Localization for FKBP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP11 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FKBP11 Gene COMPARTMENTS Subcellular localization image for FKBP11 gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 2
cytoskeleton 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FKBP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IBA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FKBP11: view

Pathways for FKBP11 Gene

SuperPathways for FKBP11 Gene

No Data Available

Interacting Proteins for FKBP11 Gene

Gene Ontology (GO) - Biological Process for FKBP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IBA --
GO:0006457 protein folding --
GO:0061077 chaperone-mediated protein folding IBA --
genes like me logo Genes that share ontologies with FKBP11: view

No data available for Pathways by source for FKBP11 Gene

Transcripts for FKBP11 Gene

mRNA/cDNA for FKBP11 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FKBP11 Gene

FK506 binding protein 11, 19 kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP11 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: -
SP5:
SP6: -

Relevant External Links for FKBP11 Gene

GeneLoc Exon Structure for
FKBP11
ECgene alternative splicing isoforms for
FKBP11

Expression for FKBP11 Gene

mRNA expression in normal human tissues for FKBP11 Gene

mRNA differential expression in normal tissues according to GTEx for FKBP11 Gene

This gene is overexpressed in Pancreas (8.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FKBP11 Gene

SOURCE GeneReport for Unigene cluster for FKBP11 Gene Hs.655103

genes like me logo Genes that share expressions with FKBP11: view

Orthologs for FKBP11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FKBP11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FKBP11 36
  • 100 (n)
  • 100 (a)
FKBP11 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FKBP11 36
  • 91.58 (n)
  • 90.66 (a)
FKBP11 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FKBP11 36
  • 91.99 (n)
  • 93.44 (a)
FKBP11 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fkbp11 36
  • 87.73 (n)
  • 91.76 (a)
Fkbp11 16
Fkbp11 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fkbp11 36
  • 89.19 (n)
  • 90.11 (a)
lizard
(Anolis carolinensis)
Reptilia FKBP11 37
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23956 36
tropical clawed frog
(Silurana tropicalis)
Amphibia fkbp11 36
  • 63.73 (n)
  • 61.03 (a)
Str.15739 36
zebrafish
(Danio rerio)
Actinopterygii fkbp11 36
  • 57.77 (n)
  • 52.84 (a)
fkbp11 37
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14715 37
  • 33 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea fkb-1 37
  • 39 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPR2 37
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 34 (a)
OneToMany
Species with no ortholog for FKBP11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FKBP11 Gene

ENSEMBL:
Gene Tree for FKBP11 (if available)
TreeFam:
Gene Tree for FKBP11 (if available)

Paralogs for FKBP11 Gene

Paralogs for FKBP11 Gene

genes like me logo Genes that share paralogs with FKBP11: view

Variants for FKBP11 Gene

Sequence variations from dbSNP and Humsavar for FKBP11 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2272312 -- 48,925,487(+) GCAGC(C/T)AGGAC upstream-variant-2KB, utr-variant-5-prime
rs2293448 -- 48,924,069(+) AGGCT(C/T)TGAAT intron-variant
rs2293449 -- 48,924,763(+) CTAGC(A/G)TTCCC intron-variant
rs3759146 -- 48,925,916(+) CAAGT(C/T)GTCTC upstream-variant-2KB
rs3825182 -- 48,925,701(+) CCAAA(C/T)AATAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FKBP11 Gene

Variant ID Type Subtype PubMed ID
nsv832404 CNV Gain 17160897

Relevant External Links for FKBP11 Gene

HapMap Linkage Disequilibrium report
FKBP11

Disorders for FKBP11 Gene

No disorders were found for FKBP11 Gene.

No data available for UniProtKB/Swiss-Prot for FKBP11 Gene

Publications for FKBP11 Gene

  1. The human FK506-binding proteins: characterization of human FKBP19. (PMID: 16596453) Rulten S.L. … Kay J.E. (Mamm. Genome 2006) 2 3 23
  2. Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family. (PMID: 12036304) Patterson C.E. … Davis E.C. (Genomics 2002) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Defining the membrane proteome of NK cells. (PMID: 19946888) Ghosh D. … Wilkins J.A. (J Mass Spectrom 2010) 3

Products for FKBP11 Gene

Sources for FKBP11 Gene

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