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Aliases for FKBP10 Gene

Aliases for FKBP10 Gene

  • FK506 Binding Protein 10 2 3 5
  • FK506 Binding Protein 10, 65 KDa 2 3
  • 65 KDa FK506-Binding Protein 3 4
  • Immunophilin FKBP65 3 4
  • PPIase FKBP10 3 4
  • 65 KDa FKBP 3 4
  • EC 4 58
  • Rotamase 3 4
  • FKBP-10 3 4
  • FKBP-65 3 4
  • FKBP65 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase FKBP10 3
  • FK506 Binding Protein 10 (65 KDa) 2
  • FK506-Binding Protein 10 4
  • HFKBP65 3
  • PPIASE 3
  • BRKS1 3
  • OI11 3
  • OI6 3

External Ids for FKBP10 Gene

Previous GeneCards Identifiers for FKBP10 Gene

  • GC17P039525
  • GC17P042056
  • GC17P039877
  • GC17P040342
  • GC17P037222
  • GC17P039968
  • GC17P035730

Summaries for FKBP10 Gene

Entrez Gene Summary for FKBP10 Gene

  • The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. This protein localizes to the endoplasmic reticulum and acts as a molecular chaperone. Alternatively spliced variants encoding different isoforms have been reported, but their biological validity has not been determined.[provided by RefSeq, Nov 2009]

GeneCards Summary for FKBP10 Gene

FKBP10 (FK506 Binding Protein 10) is a Protein Coding gene. Diseases associated with FKBP10 include Bruck Syndrome 1 and Osteogenesis Imperfecta, Type Xi. GO annotations related to this gene include calcium ion binding and FK506 binding. An important paralog of this gene is FKBP9.

UniProtKB/Swiss-Prot for FKBP10 Gene

  • PPIases accelerate the folding of proteins during protein synthesis.

Gene Wiki entry for FKBP10 Gene

Additional gene information for FKBP10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBP10 Gene

Genomics for FKBP10 Gene

Regulatory Elements for FKBP10 Gene

Enhancers for FKBP10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H042565 1.4 ENCODE dbSUPER 13.3 +755.2 755177 3.4 HDGF MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 CNTNAP1 TUBG2 CAVIN1 FKBP10 ENSG00000259623 VAT1 ENSG00000267765 RPL27 HSD17B1P1 MLX
GH17H041687 1.7 Ensembl ENCODE dbSUPER 10.4 -121.9 -121864 6.1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZFP41 ENSG00000267758 ENSG00000259623 KLHL10 CNTNAP1 HSD17B1 NT5C3B KAT2A KLHL11 ACLY TMEM99
GH17H041705 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -106.5 -106450 1.6 SOX5 SOX13 FOXA2 MNT HMG20A ZNF384 ZFHX2 ZNF366 POLR2A ZNF24 HAP1 RN7SL399P FKBP10 P3H4 KLHL10 NT5C3B ENSG00000267765 ZNF385C TTC25 GAST
GH17H041810 1.1 ENCODE 14 +0.6 551 4.4 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF302 ZNF207 ZNF143 DHX58 NT5C3B CNTD1 P3H4 FKBP10 CAVIN1 RETREG3 KAT2A HSD17B1 ENSG00000267758
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FKBP10 on UCSC Golden Path with GeneCards custom track

Promoters for FKBP10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000094294 338 2801 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF302 ZNF207 ZNF143 SP3

Genomic Locations for FKBP10 Gene

Genomic Locations for FKBP10 Gene
10,956 bases
Plus strand

Genomic View for FKBP10 Gene

Genes around FKBP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FKBP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FKBP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP10 Gene

Proteins for FKBP10 Gene

  • Protein details for FKBP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP10
    Protein Accession:
    Secondary Accessions:
    • Q7Z3R4
    • Q9H3N3
    • Q9H6J3
    • Q9H6N5
    • Q9UF89

    Protein attributes for FKBP10 Gene

    582 amino acids
    Molecular mass:
    64245 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB15220.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD97695.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FKBP10 Gene


neXtProt entry for FKBP10 Gene

Selected DME Specific Peptides for FKBP10 Gene


Post-translational modifications for FKBP10 Gene

  • Glycosylated and phosphorylated.
  • Glycosylation at isoforms=35, posLast=7070, isoforms=182, isoforms=2294, posLast=310310, isoforms=2352, isoforms=2393, and isoforms=2407
  • Modification sites at PhosphoSitePlus

Other Protein References for FKBP10 Gene

Domains & Families for FKBP10 Gene

Gene Families for FKBP10 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for FKBP10 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FKBP10: view

No data available for UniProtKB/Swiss-Prot for FKBP10 Gene

Function for FKBP10 Gene

Molecular function for FKBP10 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by both FK506 and rapamycin, but not by cyclosporin A.
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins during protein synthesis.

Enzyme Numbers (IUBMB) for FKBP10 Gene

Phenotypes From GWAS Catalog for FKBP10 Gene

Gene Ontology (GO) - Molecular Function for FKBP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA,IEA --
GO:0005509 calcium ion binding IEA --
GO:0005528 FK506 binding IBA --
GO:0016853 isomerase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FKBP10: view
genes like me logo Genes that share phenotypes with FKBP10: view

Human Phenotype Ontology for FKBP10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FKBP10 Gene

MGI Knock Outs for FKBP10:

Animal Model Products

CRISPR Products

miRNA for FKBP10 Gene

Inhibitory RNA Products

No data available for Transcription Factor Targets and HOMER Transcription for FKBP10 Gene

Localization for FKBP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP10 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FKBP10 gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 2
nucleus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FKBP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IBA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005788 endoplasmic reticulum lumen IEA --
genes like me logo Genes that share ontologies with FKBP10: view

Pathways & Interactions for FKBP10 Gene

SuperPathways for FKBP10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FKBP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000412 histone peptidyl-prolyl isomerization IEA --
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0018208 peptidyl-proline modification IEA --
GO:0061077 chaperone-mediated protein folding IBA --
genes like me logo Genes that share ontologies with FKBP10: view

No data available for Pathways by source and SIGNOR curated interactions for FKBP10 Gene

Drugs & Compounds for FKBP10 Gene

No Compound Related Data Available

Transcripts for FKBP10 Gene

Unigene Clusters for FKBP10 Gene

FK506 binding protein 10, 65 kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP10 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a ·
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP6: - -
SP7: -
SP8: - -
SP9: - - - -

ExUns: 16b · 16c ^ 17
SP11: -

Relevant External Links for FKBP10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FKBP10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FKBP10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FKBP10 Gene

This gene is overexpressed in Bone marrow stromal cell (31.2) and Liver (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FKBP10 Gene

Protein tissue co-expression partners for FKBP10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FKBP10 Gene:


SOURCE GeneReport for Unigene cluster for FKBP10 Gene:


Evidence on tissue expression from TISSUES for FKBP10 Gene

  • Nervous system(4.8)
  • Liver(4.2)
  • Skin(3.5)
  • Kidney(3)
  • Lung(2.7)

Phenotype-based relationships between genes and organs from Gene ORGANizer for FKBP10 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Head and neck:
  • brain
  • cheek
  • chin
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • middle ear
  • mouth
  • neck
  • nose
  • skull
  • tongue
  • tooth
  • vocal cord
  • chest wall
  • clavicle
  • heart
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
  • abdominal wall
  • biliary tract
  • intestine
  • kidney
  • liver
  • stomach
  • pelvis
  • ureter
  • uterus
  • vagina
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
  • blood
  • blood vessel
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • spinal cord
  • vertebrae
genes like me logo Genes that share expression patterns with FKBP10: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FKBP10 Gene

Orthologs for FKBP10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FKBP10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FKBP10 33 34
  • 99.48 (n)
(Canis familiaris)
Mammalia FKBP10 33 34
  • 90.44 (n)
(Bos Taurus)
Mammalia FKBP10 33 34
  • 90.09 (n)
(Monodelphis domestica)
Mammalia FKBP10 34
  • 87 (a)
(Mus musculus)
Mammalia Fkbp10 33 16 34
  • 86.06 (n)
(Rattus norvegicus)
Mammalia Fkbp10 33
  • 85.48 (n)
(Ornithorhynchus anatinus)
Mammalia FKBP10 34
  • 76 (a)
(Gallus gallus)
Aves FKBP10 33 34
  • 77.58 (n)
(Anolis carolinensis)
Reptilia FKBP10 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fkbp10 33
  • 70.1 (n)
Str.2813 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398175 33
(Danio rerio)
Actinopterygii fkbp10b 33 34
  • 61.45 (n)
fkbp10a 34
  • 57 (a)
Dr.3212 33
fruit fly
(Drosophila melanogaster)
Insecta CG14715 34
  • 41 (a)
(Caenorhabditis elegans)
Secernentea fkb-3 34
  • 29 (a)
fkb-4 34
  • 29 (a)
fkb-5 34
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPR2 34
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5986 34
  • 42 (a)
Species where no ortholog for FKBP10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FKBP10 Gene

Gene Tree for FKBP10 (if available)
Gene Tree for FKBP10 (if available)

Paralogs for FKBP10 Gene

Paralogs for FKBP10 Gene Pseudogenes for FKBP10 Gene

genes like me logo Genes that share paralogs with FKBP10: view

Variants for FKBP10 Gene

Sequence variations from dbSNP and Humsavar for FKBP10 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs387906960 Pathogenic, Bruck syndrome 1 (BRKS1) [MIM:259450] 41,817,156(+) GCGGC(A/G)ACGCC intron-variant, reference, missense
rs397514674 Pathogenic, Bruck syndrome 1 (BRKS1) [MIM:259450] 41,817,149(+) TCAAC(A/C/G)AGCGG intron-variant, reference, missense
rs782653042 Bruck syndrome 1 (BRKS1) [MIM:259450] 41,818,104(+) TCCAC(C/T)GGATG reference, missense
rs372896892 Pathogenic 41,820,412(+) TTGTT(C/G/T)GATAC reference, missense, stop-gained
rs387907325 Pathogenic 41,819,560(+) CCTAT(-/T)ATCGG reference, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for FKBP10 Gene

Variant ID Type Subtype PubMed ID
nsv833447 CNV loss 17160897
nsv1146669 OTHER inversion 26484159
nsv1060502 CNV gain 25217958
esv2715941 CNV deletion 23290073
dgv3174n100 CNV gain 25217958

Variation tolerance for FKBP10 Gene

Residual Variation Intolerance Score: 9.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.20; 39.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FKBP10 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FKBP10 Gene

Disorders for FKBP10 Gene

MalaCards: The human disease database

(11) MalaCards diseases for FKBP10 Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
bruck syndrome 1
  • osteogenesis imperfecta with congenital joint contractures
osteogenesis imperfecta, type xi
  • osteogenesis imperfecta type 11
moved to 259450
  • arthrogryposis-like syndrome
osteogenesis imperfecta, type xii
  • osteogenesis imperfecta type 12
bruck syndrome
  • osteogenesis imperfecta with congenital joint contractures
- elite association - COSMIC cancer census association via MalaCards


  • Bruck syndrome 1 (BRKS1) [MIM:259450]: A disease characterized by generalized osteopenia, congenital joint contractures, fragile bones with onset of fractures in infancy or early childhood, short stature, severe limb deformity, progressive scoliosis, and pterygia. {ECO:0000269 PubMed:20839288, ECO:0000269 PubMed:22949511}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Osteogenesis imperfecta 11 (OI11) [MIM:610968]: A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI11 is an autosomal recessive form. {ECO:0000269 PubMed:20362275, ECO:0000269 PubMed:20839288, ECO:0000269 PubMed:22949511}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for FKBP10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FKBP10: view

No data available for Genatlas for FKBP10 Gene

Publications for FKBP10 Gene

  1. The rough endoplasmic reticulum-resident FK506-binding protein FKBP65 is a molecular chaperone that interacts with collagens. (PMID: 18786928) Ishikawa Y … Bächinger HP (The Journal of biological chemistry 2008) 2 3 22 60
  2. Mutations in FKBP10, which result in Bruck syndrome and recessive forms of osteogenesis imperfecta, inhibit the hydroxylation of telopeptide lysines in bone collagen. (PMID: 22949511) Schwarze U … Byers PH (Human molecular genetics 2013) 3 4 60
  3. Mutations in FKBP10 cause recessive osteogenesis imperfecta and Bruck syndrome. (PMID: 20839288) Kelley BP … Lee B (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011) 3 4 60
  4. Mutations in the gene encoding the RER protein FKBP65 cause autosomal-recessive osteogenesis imperfecta. (PMID: 20362275) Alanay Y … Krakow D (American journal of human genetics 2010) 3 4 60
  5. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 60

Products for FKBP10 Gene

Sources for FKBP10 Gene

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