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Aliases for FKBP10 Gene

Aliases for FKBP10 Gene

  • FK506 Binding Protein 10 2 3 5
  • FK506 Binding Protein 10, 65 KDa 2 3
  • 65 KDa FK506-Binding Protein 3 4
  • FK506-Binding Protein 10 3 4
  • Immunophilin FKBP65 3 4
  • PPIase FKBP10 3 4
  • 65 KDa FKBP 3 4
  • EC 5.2.1.8 4 63
  • Rotamase 3 4
  • FKBP-10 3 4
  • FKBP-65 3 4
  • FKBP65 3 4
  • FK506 Binding Protein 10 (65 KDa) 2
  • HFKBP65 3
  • PPIASE 3
  • BRKS1 3
  • OI11 3
  • OI6 3

External Ids for FKBP10 Gene

Previous GeneCards Identifiers for FKBP10 Gene

  • GC17P039525
  • GC17P042056
  • GC17P039877
  • GC17P040342
  • GC17P037222
  • GC17P039968
  • GC17P035730

Summaries for FKBP10 Gene

Entrez Gene Summary for FKBP10 Gene

  • The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. This protein localizes to the endoplasmic reticulum and acts as a molecular chaperone. Alternatively spliced variants encoding different isoforms have been reported, but their biological validity has not been determined.[provided by RefSeq, Nov 2009]

GeneCards Summary for FKBP10 Gene

FKBP10 (FK506 Binding Protein 10) is a Protein Coding gene. Diseases associated with FKBP10 include bruck syndrome 1 and osteogenesis imperfecta, type xi. GO annotations related to this gene include calcium ion binding and FK506 binding. An important paralog of this gene is FKBP7.

UniProtKB/Swiss-Prot for FKBP10 Gene

  • PPIases accelerate the folding of proteins during protein synthesis.

Gene Wiki entry for FKBP10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBP10 Gene

Genomics for FKBP10 Gene

Regulatory Elements for FKBP10 Gene

Enhancers for FKBP10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FKBP10 on UCSC Golden Path with GeneCards custom track

Promoters for FKBP10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FKBP10 on UCSC Golden Path with GeneCards custom track

Genomic Location for FKBP10 Gene

Chromosome:
17
Start:
41,812,262 bp from pter
End:
41,823,217 bp from pter
Size:
10,956 bases
Orientation:
Plus strand

Genomic View for FKBP10 Gene

Genes around FKBP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FKBP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FKBP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP10 Gene

Proteins for FKBP10 Gene

  • Protein details for FKBP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AY3-FKB10_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP10
    Protein Accession:
    Q96AY3
    Secondary Accessions:
    • Q7Z3R4
    • Q9H3N3
    • Q9H6J3
    • Q9H6N5
    • Q9UF89

    Protein attributes for FKBP10 Gene

    Size:
    582 amino acids
    Molecular mass:
    64245 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15220.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD97695.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FKBP10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FKBP10 Gene

Proteomics data for FKBP10 Gene at MOPED

Selected DME Specific Peptides for FKBP10 Gene

Post-translational modifications for FKBP10 Gene

  • Glycosylated and phosphorylated.
  • Glycosylation at Ser 35, Asn 70, Asn 182, Asn 294, Asn 310, Asn 352, Asn 393, and Asn 407
  • Modification sites at PhosphoSitePlus

Other Protein References for FKBP10 Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for FKBP10

Domains & Families for FKBP10 Gene

Protein Domains for FKBP10 Gene

Suggested Antigen Peptide Sequences for FKBP10 Gene

Graphical View of Domain Structure for InterPro Entry

Q96AY3

UniProtKB/Swiss-Prot:

FKB10_HUMAN :
  • Contains 2 EF-hand domains.
Domain:
  • Contains 2 EF-hand domains.
  • Contains 4 PPIase FKBP-type domains.
genes like me logo Genes that share domains with FKBP10: view

Function for FKBP10 Gene

Molecular function for FKBP10 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by both FK506 and rapamycin, but not by cyclosporin A.
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins during protein synthesis.

Enzyme Numbers (IUBMB) for FKBP10 Gene

Gene Ontology (GO) - Molecular Function for FKBP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with FKBP10: view
genes like me logo Genes that share phenotypes with FKBP10: view

Human Phenotype Ontology for FKBP10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FKBP10 Gene

MGI Knock Outs for FKBP10:

Animal Model Products

  • Taconic Biosciences Mouse Models for FKBP10

miRNA for FKBP10 Gene

No data available for Transcription Factor Targets and HOMER Transcription for FKBP10 Gene

Localization for FKBP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP10 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FKBP10 Gene COMPARTMENTS Subcellular localization image for FKBP10 gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for FKBP10 Gene

Pathways & Interactions for FKBP10 Gene

SuperPathways for FKBP10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FKBP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0061077 chaperone-mediated protein folding IBA --
genes like me logo Genes that share ontologies with FKBP10: view

No data available for Pathways by source and SIGNOR curated interactions for FKBP10 Gene

Drugs & Compounds for FKBP10 Gene

No Compound Related Data Available

Transcripts for FKBP10 Gene

Unigene Clusters for FKBP10 Gene

FK506 binding protein 10, 65 kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP10 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a ·
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5:
SP6: - -
SP7: -
SP8: - -
SP9: - - - -
SP10:
SP11:
SP12:

ExUns: 16b · 16c ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:

Relevant External Links for FKBP10 Gene

GeneLoc Exon Structure for
FKBP10
ECgene alternative splicing isoforms for
FKBP10

Expression for FKBP10 Gene

mRNA expression in normal human tissues for FKBP10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FKBP10 Gene

This gene is overexpressed in Bone marrow stromal cell (31.2) and Liver (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FKBP10 Gene



SOURCE GeneReport for Unigene cluster for FKBP10 Gene Hs.463035

genes like me logo Genes that share expression patterns with FKBP10: view

Protein tissue co-expression partners for FKBP10 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FKBP10 Gene

Orthologs for FKBP10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FKBP10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FKBP10 35
  • 90.09 (n)
  • 94.16 (a)
FKBP10 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FKBP10 35
  • 90.44 (n)
  • 92.44 (a)
FKBP10 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fkbp10 35
  • 86.06 (n)
  • 88.98 (a)
Fkbp10 16
Fkbp10 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FKBP10 35
  • 99.48 (n)
  • 99.14 (a)
FKBP10 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fkbp10 35
  • 85.48 (n)
  • 88.64 (a)
oppossum
(Monodelphis domestica)
Mammalia FKBP10 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FKBP10 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves FKBP10 35
  • 77.58 (n)
  • 79.45 (a)
FKBP10 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FKBP10 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fkbp10 35
  • 70.1 (n)
  • 73.66 (a)
Str.2813 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398175 35
zebrafish
(Danio rerio)
Actinopterygii Dr.3212 35
fkbp10b 35
  • 61.45 (n)
  • 61.88 (a)
fkbp10a 36
  • 57 (a)
OneToMany
fkbp10b 36
  • 56 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG14715 36
  • 41 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea fkb-3 36
  • 29 (a)
ManyToMany
fkb-4 36
  • 29 (a)
ManyToMany
fkb-5 36
  • 28 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPR2 36
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5986 36
  • 42 (a)
OneToMany
Species with no ortholog for FKBP10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FKBP10 Gene

ENSEMBL:
Gene Tree for FKBP10 (if available)
TreeFam:
Gene Tree for FKBP10 (if available)

Paralogs for FKBP10 Gene

Paralogs for FKBP10 Gene

Pseudogenes.org Pseudogenes for FKBP10 Gene

genes like me logo Genes that share paralogs with FKBP10: view

Variants for FKBP10 Gene

Sequence variations from dbSNP and Humsavar for FKBP10 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs34764749 - 41,818,390(+) CAGTA(A/G)GGGCG reference, missense
VAR_069902 Bruck syndrome 1 (BRKS1)
VAR_069903 Bruck syndrome 1 (BRKS1)
VAR_069904 Bruck syndrome 1 (BRKS1)
rs1043002 -- 41,822,810(+) CCCCT(A/T)TTCCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FKBP10 Gene

Variant ID Type Subtype PubMed ID
dgv3168n71 CNV Loss 21882294
nsv833447 CNV Loss 17160897
nsv908238 CNV Loss 21882294
esv2715941 CNV Deletion 23290073

Variation tolerance for FKBP10 Gene

Residual Variation Intolerance Score: 9.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.20; 39.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FKBP10 Gene

HapMap Linkage Disequilibrium report
FKBP10
Human Gene Mutation Database (HGMD)
FKBP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FKBP10 Gene

Disorders for FKBP10 Gene

MalaCards: The human disease database

(12) MalaCards diseases for FKBP10 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
bruck syndrome 1
  • osteogenesis imperfecta with congenital joint contractures
osteogenesis imperfecta, type xi
  • osteogenesis imperfecta type xi
osteogenesis imperfecta, type vi
  • osteogenesis imperfecta type vi
osteogenesis imperfecta, type xii
  • osteogenesis imperfecta type xii
osteogenesis imperfecta, type iii
  • oi type iii
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

FKB10_HUMAN
  • Bruck syndrome 1 (BRKS1) [MIM:259450]: A disease characterized by generalized osteopenia, congenital joint contractures, fragile bones with onset of fractures in infancy or early childhood, short stature, severe limb deformity, progressive scoliosis, and pterygia. {ECO:0000269 PubMed:20839288, ECO:0000269 PubMed:22949511}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Osteogenesis imperfecta 11 (OI11) [MIM:610968]: A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI11 is an autosomal recessive form. {ECO:0000269 PubMed:20362275, ECO:0000269 PubMed:20839288, ECO:0000269 PubMed:22949511}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for FKBP10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FKBP10
genes like me logo Genes that share disorders with FKBP10: view

No data available for Genatlas for FKBP10 Gene

Publications for FKBP10 Gene

  1. The rough endoplasmic reticulum-resident FK506-binding protein FKBP65 is a molecular chaperone that interacts with collagens. (PMID: 18786928) Ishikawa Y. … BAochinger H.P. (J. Biol. Chem. 2008) 2 3 23 67
  2. Developmental regulation and coordinate reexpression of FKBP65 with extracellular matrix proteins after lung injury suggest a specialized function for this endoplasmic reticulum immunophilin. (PMID: 16333983) Patterson C.E. … Davis E.C. (Cell Stress Chaperones 2005) 3 23
  3. Developmental regulation of FKBP65. An ER-localized extracellular matrix binding-protein. (PMID: 11071917) Patterson C.E. … Davis E.C. (Mol. Biol. Cell 2000) 2 3
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  5. HSP47 and FKBP65 cooperate in the synthesis of type I procollagen. (PMID: 25510505) Duran I. … Cohn D.H. (Hum. Mol. Genet. 2015) 3

Products for FKBP10 Gene

Sources for FKBP10 Gene

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