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Aliases for FJX1 Gene

Aliases for FJX1 Gene

  • Four Jointed Box 1 (Drosophila) 2 3
  • Putative Secreted Ligand Homologous To Fjx1 2
  • Four-Jointed Protein Homolog 4

External Ids for FJX1 Gene

Previous GeneCards Identifiers for FJX1 Gene

  • GC11P037192
  • GC11P036317
  • GC11P035678
  • GC11P035604
  • GC11P035338

Summaries for FJX1 Gene

Entrez Gene Summary for FJX1 Gene

  • The protein encoded by this gene is the human ortholog of mouse and Drosophila four-jointed gene product. The Drosophila protein is important for growth and differentiation of legs and wings, and for proper development of the eyes. The exact function of this gene in humans is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for FJX1 Gene

FJX1 (Four Jointed Box 1 (Drosophila)) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FJX1 Gene

  • Acts as an inhibitor of dendrite extension and branching.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FJX1 Gene

Genomics for FJX1 Gene

Regulatory Elements for FJX1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FJX1 Gene

35,618,187 bp from pter
35,620,873 bp from pter
2,687 bases
Plus strand

Genomic View for FJX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FJX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FJX1 Gene

Proteins for FJX1 Gene

  • Protein details for FJX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Four-jointed box protein 1
    Protein Accession:
    Secondary Accessions:
    • B2RCA9
    • Q9UGK6

    Protein attributes for FJX1 Gene

    437 amino acids
    Molecular mass:
    48507 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAB53246.1; Type=Frameshift; Positions=436; Evidence={ECO:0000305};

neXtProt entry for FJX1 Gene

Proteomics data for FJX1 Gene at MOPED

Post-translational modifications for FJX1 Gene

Other Protein References for FJX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FJX1 Gene

Domains for FJX1 Gene

Protein Domains for FJX1 Gene


Suggested Antigen Peptide Sequences for FJX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FJX1/FJ family.
  • Belongs to the FJX1/FJ family.
genes like me logo Genes that share domains with FJX1: view

No data available for Gene Families for FJX1 Gene

Function for FJX1 Gene

Molecular function for FJX1 Gene

GENATLAS Biochemistry:
putative secreted ligand,homolog to Drosophila four jointed box 1,and to murine Fjx1,coding for a putative secreted protein,expressed in restricted domains of the developing and adult brain
UniProtKB/Swiss-Prot Function:
Acts as an inhibitor of dendrite extension and branching.
genes like me logo Genes that share phenotypes with FJX1: view

Animal Model Products

miRNA for FJX1 Gene

miRTarBase miRNAs that target FJX1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FJX1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for FJX1 Gene

Localization for FJX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FJX1 Gene


Subcellular locations from

Jensen Localization Image for FJX1 Gene COMPARTMENTS Subcellular localization image for FJX1 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FJX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with FJX1: view

Pathways for FJX1 Gene

SuperPathways for FJX1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for FJX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010842 retina layer formation IEA --
genes like me logo Genes that share ontologies with FJX1: view

No data available for Pathways by source for FJX1 Gene

Transcripts for FJX1 Gene

mRNA/cDNA for FJX1 Gene

Unigene Clusters for FJX1 Gene

Four jointed box 1 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FJX1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FJX1 Gene

No ASD Table

Relevant External Links for FJX1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FJX1 Gene

mRNA expression in normal human tissues for FJX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FJX1 Gene

SOURCE GeneReport for Unigene cluster for FJX1 Gene Hs.39384

genes like me logo Genes that share expressions with FJX1: view

Expression partners for FJX1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FJX1 Gene

Orthologs for FJX1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FJX1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FJX1 35
  • 91.84 (n)
  • 96.6 (a)
FJX1 36
  • 97 (a)
(Canis familiaris)
Mammalia FJX1 35
  • 89.3 (n)
  • 90.62 (a)
FJX1 36
  • 87 (a)
(Mus musculus)
Mammalia Fjx1 35
  • 88.23 (n)
  • 90.37 (a)
Fjx1 16
Fjx1 36
  • 88 (a)
(Pan troglodytes)
Mammalia FJX1 35
  • 99.24 (n)
  • 99.08 (a)
FJX1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fjx1 35
  • 88.05 (n)
  • 91.26 (a)
(Monodelphis domestica)
Mammalia FJX1 36
  • 77 (a)
(Anolis carolinensis)
Reptilia FJX1 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fjx1 35
  • 60.61 (n)
  • 55.76 (a)
(Danio rerio)
Actinopterygii LOC100001423 35
  • 56.38 (n)
  • 51.68 (a)
FJX1 36
  • 50 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008093 35
  • 52.86 (n)
  • 38.94 (a)
fruit fly
(Drosophila melanogaster)
Insecta fj 35
  • 51.04 (n)
  • 39.83 (a)
fj 36
  • 24 (a)
Species with no ortholog for FJX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FJX1 Gene

Gene Tree for FJX1 (if available)
Gene Tree for FJX1 (if available)

Paralogs for FJX1 Gene

No data available for Paralogs for FJX1 Gene

Variants for FJX1 Gene

Sequence variations from dbSNP and Humsavar for FJX1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs474415 -- 35,621,175(-) ATATA(C/T)TACAG downstream-variant-500B
rs676419 -- 35,619,075(-) AGCCG(C/T)CTCCA missense, reference
rs697315 -- 35,617,224(+) CCCCC(A/C)CCACC upstream-variant-2KB
rs1184986 -- 35,618,756(-) GGCGG(A/C)CGGGA reference, synonymous-codon
rs3740799 -- 35,619,764(-) AGCTC(C/T)AGGAC synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for FJX1 Gene

Variant ID Type Subtype PubMed ID
nsv832121 CNV Gain 17160897
nsv897223 CNV Loss 21882294

Relevant External Links for FJX1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FJX1 Gene

Disorders for FJX1 Gene

No disorders were found for FJX1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FJX1 Gene

Publications for FJX1 Gene

  1. A 7.5 Mb sequence-ready PAC contig and gene expression map of human chromosome 11p13-p14.1. (PMID: 10568747) Gawin B. … Gessler M. (Genome Res. 1999) 3 4
  2. Fjx1, the murine homologue of the Drosophila four-jointed gene, codes for a putative secreted protein expressed in restricted domains of the developing and adult brain. (PMID: 10072791) Ashery-Padan R. … Gruss P. (Mech. Dev. 1999) 2 3
  3. CpG island clones for chromosome 11p--a resource for mapping and gene identification. (PMID: 7647465) ThAote C. … Gessler M. (Mamm. Genome 1995) 2 3
  4. Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease. (PMID: 18604206) Saburi S. … McNeill H. (Nat. Genet. 2008) 23
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FJX1 Gene

Sources for FJX1 Gene

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