FIZ1 Gene
protein-coding GIFtS: 46
GCID: GC19M056102
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|
FLT3-interacting zinc finger 1
| |
Aliases
for FIZ1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| FLT3-Interacting Zinc Finger 11 2 | | ZNF7981 2 3 | | Zinc Finger Protein 7982 3 | | FLJ147681 | | Flt3-Interacting Zinc Finger Protein 12 |
| External Ids: | HGNC: 259171 | Entrez Gene: 849222 | Ensembl: ENSG000001799437 | OMIM: 6091335 | UniProtKB: Q96SL83 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n338955 | |
Export aliases for FIZ1 gene to outside databasesPrevious GC identifers: GC19M060795 GC19M052413
Summaries
for FIZ1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FIZ1:
This gene encodes zinc finger protein, which interacts with a receptor tyrosine kinase involved in the regulation ofhematopoietic and lymphoid cells. This gene product also interacts with a transcription factor that regulates theexpression of rod-specific genes in retina. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: FIZ1_HUMAN, Q96SL8Function: May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediatedtransactivation (By similarity)
|
Genomic Views
for FIZ1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FIZ1 gene promoter:
STAT5B RP58 MAZR Pax-5 p53 NF-kappaB HEN1 E2F-1 E2F NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FIZ1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FIZ1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.42 Ensembl cytogenetic band: 19q13.42 HGNC cytogenetic band: 19q13.42FIZ1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M056102: view genomic region
(about GC identifiers)
Start:
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56,102,737 bp from pter |
End:
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56,113,336 bp from pter |
Size:
|
10,600 bases |
Orientation:
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minus strand |
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Proteins
for FIZ1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FIZ1_HUMAN, Q96SL8 (See
protein sequence)Recommended Name: Flt3-interacting zinc finger protein 1 Size: 496 amino acids; 51996 Da
Subunit: Interacts with FLT3 cytoplasmic catalytic domain, following receptor stimulation, in a kinase-independentmanner. Does not interact with other structurally related receptor tyrosine kinases, including KIT, CSF1R and PDGFR.Interacts with NRL (By similarity)
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Sequence caution: Sequence=BAD18728.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A2RU72 Q6ZMJ7Explore the universe of human proteins at neXtProt for FIZ1: NX_Q96SL8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96SL8
FIZ1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_116225.2
ENSEMBL proteins: ENSP00000221665 ENSP00000465131 ENSP00000468529 ENSP00000468342 ENSP00000468018
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
FIZ1 for ontologies About GeneDecksing
FIZ1 Antibody Products:
Assay Products for FIZ1: |
Protein
Domains /
Families
for FIZ1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FIZ1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96SL8ProtoNet protein and cluster: Q96SL8 UniProtKB/Swiss-Prot: FIZ1_HUMAN, Q96SL8Similarity: Contains 11 C2H2-type zinc fingers |
Function
for FIZ1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FIZ1_HUMAN, Q96SL8Function: May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediatedtransactivation (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FIZ1 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FIZ1
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FIZ1 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
FIZ1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for FIZ1:
|
Pathways & Interactions
for FIZ1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FIZ1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
4 Interacting proteins for FIZ1 (Q96SL83 ENSP000002216654) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
FIZ1 for ontologies About GeneDecksing
|
Drugs & Compounds
for FIZ1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FIZ1
Search CenterWatch for drugs/clinical trials and news about FIZ1
|
Transcripts
for FIZ1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FIZ1 gene: NM_032836.2 Unigene Cluster for FIZ1: FLT3-interacting zinc finger 1 Hs.515617 [show with all ESTs]Unigene Representative Sequence: NM_0328365 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000221665(uc002qli.4 uc002qlj.4) ENST00000590714 ENST00000592585
ENST00000587678 ENST00000587414
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FIZ1 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FIZ1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FIZ1 (NM_032836) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FIZ1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FIZ1 |
Additional cDNA sequence: AK027674.1 BC020368.1 BC132777.1 BC136512.1 5 DOTS entries: DT.403910 DT.95254954 DT.86846015 DT.121445746 DT.100739580 24/93 AceView cDNA sequences (see all 93): BM690768 C01696 AW409891 F23452 AW275332 BU728526 AW614655 AI096509 AI699699 BM663774 AI990725 CR596546 AW206984 CA841110 BM692120 BM479809 BC020368 BF594355 BM974765 BE383069 BU733940 BV179548 BM458729 BM971110
GeneLoc Exon Structure
|
Expression
for FIZ1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FIZ1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAATGGGCTG
About this image
See FIZ1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FIZ1
SOURCE GeneReport for Unigene cluster: Hs.515617
UniProtKB/Swiss-Prot: FIZ1_HUMAN, Q96SL8Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for FIZ1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FIZ1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FIZ1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FIZ1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FIZ1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FIZ1 |
Orthologs
for FIZ1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FIZ1 gene from 2/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
FIZ16 |
-- |
41(a) |
1 ↔ 1 |
GL343279.1(562763-581526) |
zebrafish
(Danio rerio) |
Actinopterygii |
BX323458.16 |
-- |
7(a) |
1 → many |
16(15308342-15311002) |
ENSEMBL Gene Tree for FIZ1 (if available)
TreeFam Gene Tree for FIZ1 (if available) |
Paralogs
for FIZ1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for FIZ1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FIZ1 (56102737 - 56113336 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FIZ1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FIZ1 |
|
Disorders
/ Diseases
for FIZ1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FIZ1 for disorders About GeneDecksing
OMIM gene information: 609133
OMIM disorders: --
1  disease for FIZ1: About MalaCardsretinitis
Export disorders for FIZ1 gene to outside databases
|
Publications
for FIZ1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FIZ1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FIZ1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Interaction of retinal bZIP transcription factor NRL with Flt3- interacting zinc-finger protein Fiz1: possible role of Fiz1 as a transcriptional repressor. (PubMed id 12566383)1, 2, 3, 9 Mitton K.P.... Swaroop A. (2003)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- FIZ1 is expressed during photoreceptor maturation, and synergizes with NRL and CRX at rod-specific promoters in vitro. (PubMed id 17141759)1 Mali R.S....Mitton K.P. (2007)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Fiz1, a novel zinc finger protein interacting with the receptor tyrosine kinase Flt3. (PubMed id 10409713)1 Wolf I. and Rohrschneider L.R. (1999)
|
External Searches for FIZ1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FIZ1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FIZ1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FIZ1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FIZ1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FIZ1 gene:
Search GeneIP for patents involving FIZ1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FIZ1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FIZ1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FIZ1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FIZ1 | | | OriGene Protein Over-expression Lysate for FIZ1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FIZ1 | | OriGene 3'-UTR Clone for FIZ1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FIZ1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FIZ1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FIZ1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 |  |  |  | |
| | | | Search Tocris compounds for FIZ1 |
| |  |  |  |  | | | | |
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 |
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 | | | FIZ1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FIZ1 |
|  |  |  | | | | Search ThermoFisher Antibodies for FIZ1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FIZ1 |
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