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Aliases for FIZ1 Gene

Aliases for FIZ1 Gene

  • FLT3 Interacting Zinc Finger 1 2 3 5
  • Zinc Finger Protein 798 3 4
  • ZNF798 3 4
  • Flt3-Interacting Zinc Finger Protein 1 3

External Ids for FIZ1 Gene

Previous GeneCards Identifiers for FIZ1 Gene

  • GC19M060795
  • GC19M056102
  • GC19M052413

Summaries for FIZ1 Gene

Entrez Gene Summary for FIZ1 Gene

  • This gene encodes zinc finger protein, which interacts with a receptor tyrosine kinase involved in the regulation of hematopoietic and lymphoid cells. This gene product also interacts with a transcription factor that regulates the expression of rod-specific genes in retina. [provided by RefSeq, Jul 2008]

GeneCards Summary for FIZ1 Gene

FIZ1 (FLT3 Interacting Zinc Finger 1) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and receptor tyrosine kinase binding. An important paralog of this gene is ZNF579.

UniProtKB/Swiss-Prot for FIZ1 Gene

  • May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FIZ1 Gene

Genomics for FIZ1 Gene

Regulatory Elements for FIZ1 Gene

Enhancers for FIZ1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F055519 1.6 FANTOM5 Ensembl ENCODE 32.6 +81.8 81761 1.0 HDGF ATF1 ZNF493 ZNF133 GLI4 YBX1 ZNF416 ZNF548 FOS MCM3 FIZ1 ZNF580 NAT14 U2AF2 SHISA7 ZNF667 ZNF667-AS1 SSC5D SBK3 LOC100506374
GH19F055503 1.3 Ensembl ENCODE 19.2 +98.0 98002 1.6 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF416 ZNF143 ZNF548 U2AF2 ZNF667 FIZ1 ZNF667-AS1 NAT14 LOC100506374 ZNF580 ZNF582-AS1 ENSG00000267523 KMT5C
GH19F055405 1.4 FANTOM5 ENCODE 11.1 +194.5 194545 3.7 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF416 ZNF207 ENSG00000269873 NAT14 MIR6805 LOC100506374 ZNF581 U2AF2 ZNF582-AS1 ZNF580 FIZ1 RPL28
GH19F055516 1.3 Ensembl ENCODE 11.3 +84.8 84804 1.3 HDGF ATF1 ARID4B SIN3A GLI4 BRCA1 CBX5 ZNF143 FOS KLF13 SBK2 SBK3 SSC5D NAT14 ZNF580 ZNF581 CCDC106 ZNF628 FIZ1 ZNF524
GH19F055671 1.1 ENCODE 12.8 -74.5 -74533 10.0 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF583 ZNF470 ZNF582-AS1 ENSG00000269696 ZNF542P ZNF667-AS1 ENSG00000267224 ZFP28 ZNF667 LOC729999
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FIZ1 on UCSC Golden Path with GeneCards custom track

Promoters for FIZ1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001818972 470 201 BCOR CBX3 PKNOX1 ZNF792 ZMYM3 HDAC2 ADNP KDM1A ZNF391 ZNF24

Genomic Location for FIZ1 Gene

Chromosome:
19
Start:
55,591,371 bp from pter
End:
55,601,970 bp from pter
Size:
10,600 bases
Orientation:
Minus strand

Genomic View for FIZ1 Gene

Genes around FIZ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FIZ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FIZ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FIZ1 Gene

Proteins for FIZ1 Gene

  • Protein details for FIZ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SL8-FIZ1_HUMAN
    Recommended name:
    Flt3-interacting zinc finger protein 1
    Protein Accession:
    Q96SL8
    Secondary Accessions:
    • A2RU72
    • Q6ZMJ7

    Protein attributes for FIZ1 Gene

    Size:
    496 amino acids
    Molecular mass:
    51996 Da
    Quaternary structure:
    • Interacts with FLT3 cytoplasmic catalytic domain, following receptor stimulation, in a kinase-independent manner. Does not interact with other structurally related receptor tyrosine kinases, including KIT, CSF1R and PDGFR. Interacts with NRL (By similarity).
    SequenceCaution:
    • Sequence=BAD18728.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for FIZ1 Gene

Post-translational modifications for FIZ1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FIZ1 Gene

No data available for DME Specific Peptides for FIZ1 Gene

Domains & Families for FIZ1 Gene

Gene Families for FIZ1 Gene

Protein Domains for FIZ1 Gene

Suggested Antigen Peptide Sequences for FIZ1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96SL8

UniProtKB/Swiss-Prot:

FIZ1_HUMAN :
  • Contains 11 C2H2-type zinc fingers.
Similarity:
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with FIZ1: view

Function for FIZ1 Gene

Molecular function for FIZ1 Gene

UniProtKB/Swiss-Prot Function:
May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity).

Gene Ontology (GO) - Molecular Function for FIZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0030971 receptor tyrosine kinase binding IEA,ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FIZ1: view
genes like me logo Genes that share phenotypes with FIZ1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FIZ1 Gene

Localization for FIZ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FIZ1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FIZ1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for FIZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with FIZ1: view

Pathways & Interactions for FIZ1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FIZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with FIZ1: view

No data available for Pathways by source and SIGNOR curated interactions for FIZ1 Gene

Transcripts for FIZ1 Gene

Unigene Clusters for FIZ1 Gene

FLT3-interacting zinc finger 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FIZ1 Gene

No ASD Table

Relevant External Links for FIZ1 Gene

GeneLoc Exon Structure for
FIZ1
ECgene alternative splicing isoforms for
FIZ1

Expression for FIZ1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FIZ1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FIZ1 Gene

This gene is overexpressed in Lung (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FIZ1 Gene



Protein tissue co-expression partners for FIZ1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FIZ1 Gene:

FIZ1

SOURCE GeneReport for Unigene cluster for FIZ1 Gene:

Hs.515617

mRNA Expression by UniProt/SwissProt for FIZ1 Gene:

Q96SL8-FIZ1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with FIZ1: view

Primer Products

No data available for mRNA differential expression in normal tissues for FIZ1 Gene

Orthologs for FIZ1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FIZ1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FIZ1 34 35
  • 99.53 (n)
dog
(Canis familiaris)
Mammalia FIZ1 34
  • 88.33 (n)
cow
(Bos Taurus)
Mammalia FIZ1 34 35
  • 88.26 (n)
mouse
(Mus musculus)
Mammalia Fiz1 34 16 35
  • 80.37 (n)
rat
(Rattus norvegicus)
Mammalia Fiz1 34
  • 80.08 (n)
lizard
(Anolis carolinensis)
Reptilia FIZ1 35
  • 48 (a)
OneToOne
Species where no ortholog for FIZ1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FIZ1 Gene

ENSEMBL:
Gene Tree for FIZ1 (if available)
TreeFam:
Gene Tree for FIZ1 (if available)

Paralogs for FIZ1 Gene

Paralogs for FIZ1 Gene

genes like me logo Genes that share paralogs with FIZ1: view

Variants for FIZ1 Gene

Sequence variations from dbSNP and Humsavar for FIZ1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs546265268 Uncertain significance 55,593,057(+) GGCCC(A/C)GGAGC reference, missense
rs10403342 -- 55,601,575(+) TTCCT(C/T)ATCCA intron-variant, upstream-variant-2KB
rs10403432 -- 55,593,158(+) CAGGC(C/T)TGCGC reference, synonymous-codon
rs10403462 -- 55,593,194(+) TCGTG(C/G)GTCAG reference, synonymous-codon
rs10411640 -- 55,593,795(+) CTCTG(C/T)TTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FIZ1 Gene

Variant ID Type Subtype PubMed ID
nsv953624 CNV deletion 24416366
nsv828643 CNV loss 20364138

Variation tolerance for FIZ1 Gene

Gene Damage Index Score: 2.22; 40.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FIZ1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FIZ1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FIZ1 Gene

Disorders for FIZ1 Gene

Relevant External Links for FIZ1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FIZ1

No disorders were found for FIZ1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FIZ1 Gene

Publications for FIZ1 Gene

  1. Interaction of retinal bZIP transcription factor NRL with Flt3- interacting zinc-finger protein Fiz1: possible role of Fiz1 as a transcriptional repressor. (PMID: 12566383) Mitton K.P. … Swaroop A. (Hum. Mol. Genet. 2003) 2 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Dissection of a novel autocrine signaling pathway via quantitative secretome and interactome mapping. (PMID: 24956037) LariviA"re N. … Trinkle-Mulcahy L. (J. Proteome Res. 2014) 3 64
  4. Genome-wide association study of chronic periodontitis in a general German population. (PMID: 24024966) Teumer A. … Kocher T. (J. Clin. Periodontol. 2013) 3 64
  5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4 64

Products for FIZ1 Gene

Sources for FIZ1 Gene

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