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Aliases for FIZ1 Gene

Aliases for FIZ1 Gene

  • FLT3 Interacting Zinc Finger 1 2 3 5
  • Zinc Finger Protein 798 3 4
  • ZNF798 3 4
  • Flt3-Interacting Zinc Finger Protein 1 3

External Ids for FIZ1 Gene

Previous GeneCards Identifiers for FIZ1 Gene

  • GC19M060795
  • GC19M056102
  • GC19M052413

Summaries for FIZ1 Gene

Entrez Gene Summary for FIZ1 Gene

  • This gene encodes zinc finger protein, which interacts with a receptor tyrosine kinase involved in the regulation of hematopoietic and lymphoid cells. This gene product also interacts with a transcription factor that regulates the expression of rod-specific genes in retina. [provided by RefSeq, Jul 2008]

GeneCards Summary for FIZ1 Gene

FIZ1 (FLT3 Interacting Zinc Finger 1) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and receptor tyrosine kinase binding. An important paralog of this gene is ZNF581.

UniProtKB/Swiss-Prot for FIZ1 Gene

  • May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FIZ1 Gene

Genomics for FIZ1 Gene

Regulatory Elements for FIZ1 Gene

Enhancers for FIZ1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G055519 1.6 FANTOM5 Ensembl ENCODE 70.8 +81.8 81761 1.0 HDGF ATF1 ZNF493 ZNF133 YBX1 GLI4 ZNF416 FOS ZNF548 SP3 FIZ1 ZNF471 NAT14 ZNF580 ZNF667 ZNF582-AS1 ZNF667-AS1 ZNF542P U2AF2 ZNF583
GH19G055503 1.3 Ensembl ENCODE 66.1 +98.0 98002 1.6 PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 CBX5 ZNF416 FIZ1 ZNF667 ZNF667-AS1 ZNF582-AS1 NAT14 ZNF542P ZNF583 U2AF2 LOC729999 ZNF580
GH19G056594 1 ENCODE 48.8 -993.5 -993471 1.4 HDGF PKNOX1 ZNF133 ARID4B SIN3A FEZF1 YBX1 GLI4 ZNF48 YY1 ZNF17 ENSG00000269696 ZNF549 ZNF773 ZNF543 U2AF2 ZFP28 ZNF667 ZNF470 FIZ1
GH19G055283 0.9 ENCODE 40.2 +317.3 317259 2.5 HDGF ZNF76 GLI4 ZNF48 ZEB1 GLIS2 ZNF366 CREM ZNF263 SMARCA5 FIZ1 NAT14 ENSG00000235681 LENG8-AS1 ZNF580 HSPBP1 ENSG00000267838 U2AF2 BRSK1 PIR47614
GH19G055215 1.5 ENCODE dbSUPER 22.8 +385.3 385266 2.9 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 LENG8-AS1 U2AF2 ENSG00000235681 ENSG00000267523 ZNF580 NAT14 ZNF581 FIZ1 ENSG00000267096 ENSG00000267265
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FIZ1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FIZ1 Gene

Chromosome:
19
Start:
55,591,371 bp from pter
End:
55,601,970 bp from pter
Size:
10,600 bases
Orientation:
Minus strand

Genomic View for FIZ1 Gene

Genes around FIZ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FIZ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FIZ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FIZ1 Gene

Proteins for FIZ1 Gene

  • Protein details for FIZ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SL8-FIZ1_HUMAN
    Recommended name:
    Flt3-interacting zinc finger protein 1
    Protein Accession:
    Q96SL8
    Secondary Accessions:
    • A2RU72
    • Q6ZMJ7

    Protein attributes for FIZ1 Gene

    Size:
    496 amino acids
    Molecular mass:
    51996 Da
    Quaternary structure:
    • Interacts with FLT3 cytoplasmic catalytic domain, following receptor stimulation, in a kinase-independent manner. Does not interact with other structurally related receptor tyrosine kinases, including KIT, CSF1R and PDGFR. Interacts with NRL (By similarity).
    SequenceCaution:
    • Sequence=BAD18728.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for FIZ1 Gene

Post-translational modifications for FIZ1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FIZ1 Gene

No data available for DME Specific Peptides for FIZ1 Gene

Domains & Families for FIZ1 Gene

Gene Families for FIZ1 Gene

Suggested Antigen Peptide Sequences for FIZ1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FIZ1: view

No data available for UniProtKB/Swiss-Prot for FIZ1 Gene

Function for FIZ1 Gene

Molecular function for FIZ1 Gene

UniProtKB/Swiss-Prot Function:
May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity).

Gene Ontology (GO) - Molecular Function for FIZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0030971 receptor tyrosine kinase binding ISS,IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FIZ1: view
genes like me logo Genes that share phenotypes with FIZ1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FIZ1 Gene

Localization for FIZ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FIZ1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FIZ1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for FIZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with FIZ1: view

Pathways & Interactions for FIZ1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FIZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with FIZ1: view

No data available for Pathways by source and SIGNOR curated interactions for FIZ1 Gene

Drugs & Compounds for FIZ1 Gene

No Compound Related Data Available

Transcripts for FIZ1 Gene

Unigene Clusters for FIZ1 Gene

FLT3-interacting zinc finger 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FIZ1 Gene

No ASD Table

Relevant External Links for FIZ1 Gene

GeneLoc Exon Structure for
FIZ1
ECgene alternative splicing isoforms for
FIZ1

Expression for FIZ1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FIZ1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FIZ1 Gene

This gene is overexpressed in Lung (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FIZ1 Gene



Protein tissue co-expression partners for FIZ1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FIZ1 Gene:

FIZ1

SOURCE GeneReport for Unigene cluster for FIZ1 Gene:

Hs.515617

mRNA Expression by UniProt/SwissProt for FIZ1 Gene:

Q96SL8-FIZ1_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for FIZ1 Gene

  • Spleen(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with FIZ1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FIZ1 Gene

Orthologs for FIZ1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FIZ1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FIZ1 34 35
  • 99.53 (n)
dog
(Canis familiaris)
Mammalia FIZ1 34
  • 88.33 (n)
cow
(Bos Taurus)
Mammalia FIZ1 34 35
  • 88.26 (n)
mouse
(Mus musculus)
Mammalia Fiz1 34 16 35
  • 80.37 (n)
rat
(Rattus norvegicus)
Mammalia Fiz1 34
  • 80.08 (n)
lizard
(Anolis carolinensis)
Reptilia FIZ1 35
  • 48 (a)
OneToOne
Species where no ortholog for FIZ1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FIZ1 Gene

ENSEMBL:
Gene Tree for FIZ1 (if available)
TreeFam:
Gene Tree for FIZ1 (if available)

Paralogs for FIZ1 Gene

Paralogs for FIZ1 Gene

genes like me logo Genes that share paralogs with FIZ1: view

Variants for FIZ1 Gene

Sequence variations from dbSNP and Humsavar for FIZ1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs546265268 Uncertain significance 55,593,057(+) GGCCC(A/C)GGAGC reference, missense
rs1000260260 -- 55,597,958(+) GCTCT(C/G)TCCTC intron-variant, upstream-variant-2KB
rs1000673695 -- 55,593,070(+) CCTGC(A/G)GTCCG reference, missense
rs1000789791 -- 55,591,336(+) CATCC(A/C)CCCCG downstream-variant-500B
rs1001117180 -- 55,597,428(+) TGGTA(C/G)GGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FIZ1 Gene

Variant ID Type Subtype PubMed ID
nsv828643 CNV loss 20364138
nsv953624 CNV deletion 24416366

Variation tolerance for FIZ1 Gene

Gene Damage Index Score: 2.22; 40.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FIZ1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FIZ1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FIZ1 Gene

Disorders for FIZ1 Gene

Relevant External Links for FIZ1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FIZ1

No disorders were found for FIZ1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FIZ1 Gene

Publications for FIZ1 Gene

  1. Interaction of retinal bZIP transcription factor NRL with Flt3- interacting zinc-finger protein Fiz1: possible role of Fiz1 as a transcriptional repressor. (PMID: 12566383) Mitton K.P. … Swaroop A. (Hum. Mol. Genet. 2003) 2 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Dissection of a novel autocrine signaling pathway via quantitative secretome and interactome mapping. (PMID: 24956037) LariviA"re N. … Trinkle-Mulcahy L. (J. Proteome Res. 2014) 3 64
  4. Genome-wide association study of chronic periodontitis in a general German population. (PMID: 24024966) Teumer A. … Kocher T. (J. Clin. Periodontol. 2013) 3 64
  5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4 64

Products for FIZ1 Gene

Sources for FIZ1 Gene

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