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Aliases for FITM2 Gene

Aliases for FITM2 Gene

  • Fat Storage Inducing Transmembrane Protein 2 2 3
  • Fat Inducing Transcript 2 2 3
  • Fat-Inducing Protein 2 3 4
  • C20orf142 3 4
  • Fit2 3 4
  • Fat Storage-Inducing Transmembrane Protein 2 5
  • Chromosome 20 Open Reading Frame 142 2
  • Fat-Inducing Transcript 2 3
  • DJ881L22.2 3

External Ids for FITM2 Gene

Previous HGNC Symbols for FITM2 Gene

  • C20orf142

Previous GeneCards Identifiers for FITM2 Gene

  • GC20M042368
  • GC20M042931

Summaries for FITM2 Gene

Entrez Gene Summary for FITM2 Gene

  • FIT2 belongs to an evolutionarily conserved family of proteins involved in fat storage (Kadereit et al., 2008 [PubMed 18160536]).[supplied by OMIM, May 2008]

GeneCards Summary for FITM2 Gene

FITM2 (Fat Storage Inducing Transmembrane Protein 2) is a Protein Coding gene. An important paralog of this gene is FITM1.

UniProtKB/Swiss-Prot for FITM2 Gene

  • Plays an important role in lipid droplet accumulation. Plays a role in the regulation of cell morphology and cytoskeletal organization.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FITM2 Gene

Genomics for FITM2 Gene

Regulatory Elements for FITM2 Gene

Enhancers for FITM2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FITM2 on UCSC Golden Path with GeneCards custom track

Promoters for FITM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FITM2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FITM2 Gene

Chromosome:
20
Start:
44,302,838 bp from pter
End:
44,311,249 bp from pter
Size:
8,412 bases
Orientation:
Minus strand

Genomic View for FITM2 Gene

Genes around FITM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FITM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FITM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FITM2 Gene

Proteins for FITM2 Gene

  • Protein details for FITM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6M3-FITM2_HUMAN
    Recommended name:
    Fat storage-inducing transmembrane protein 2
    Protein Accession:
    Q8N6M3
    Secondary Accessions:
    • A1L492
    • B9EGQ4
    • Q5TE59
    • Q9H3Y1

    Protein attributes for FITM2 Gene

    Size:
    262 amino acids
    Molecular mass:
    29855 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FITM2 Gene

Proteomics data for FITM2 Gene at MOPED

Post-translational modifications for FITM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FITM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FITM2 Gene

Domains & Families for FITM2 Gene

Protein Domains for FITM2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FITM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N6M3

UniProtKB/Swiss-Prot:

FITM2_HUMAN :
  • Belongs to the FIT family.
Family:
  • Belongs to the FIT family.
genes like me logo Genes that share domains with FITM2: view

No data available for Gene Families for FITM2 Gene

Function for FITM2 Gene

Molecular function for FITM2 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in lipid droplet accumulation. Plays a role in the regulation of cell morphology and cytoskeletal organization.
genes like me logo Genes that share phenotypes with FITM2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FITM2 Gene

Localization for FITM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FITM2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FITM2 Gene COMPARTMENTS Subcellular localization image for FITM2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
mitochondrion 2

No data available for Gene Ontology (GO) - Cellular Components for FITM2 Gene

Pathways & Interactions for FITM2 Gene

SuperPathways for FITM2 Gene

No Data Available

Interacting Proteins for FITM2 Gene

Gene Ontology (GO) - Biological Process for FITM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IMP 21834987
GO:0010866 regulation of triglyceride biosynthetic process IEA,ISS 18160536
GO:0019915 lipid storage IEA,IBA --
GO:0030730 sequestering of triglyceride IEA --
GO:0034389 lipid particle organization IEA,ISS 18160536
genes like me logo Genes that share ontologies with FITM2: view

No data available for Pathways by source and SIGNOR curated interactions for FITM2 Gene

Drugs & Compounds for FITM2 Gene

No Compound Related Data Available

Transcripts for FITM2 Gene

mRNA/cDNA for FITM2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(86) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FITM2 Gene

Fat storage-inducing transmembrane protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FITM2 Gene

No ASD Table

Relevant External Links for FITM2 Gene

GeneLoc Exon Structure for
FITM2
ECgene alternative splicing isoforms for
FITM2

Expression for FITM2 Gene

mRNA expression in normal human tissues for FITM2 Gene

mRNA differential expression in normal tissues according to GTEx for FITM2 Gene

This gene is overexpressed in Heart - Left Ventricle (x12.2) and Heart - Atrial Appendage (x6.6).

Protein differential expression in normal tissues from HIPED for FITM2 Gene

This gene is overexpressed in Heart (14.7), Liver (7.4), and Retina (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FITM2 Gene



SOURCE GeneReport for Unigene cluster for FITM2 Gene Hs.632269

mRNA Expression by UniProt/SwissProt for FITM2 Gene

Q8N6M3-FITM2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with FITM2: view

Protein tissue co-expression partners for FITM2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FITM2 Gene

Orthologs for FITM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FITM2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FITM2 35
  • 89.95 (n)
  • 92.37 (a)
FITM2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FITM2 35
  • 90.59 (n)
  • 91.98 (a)
FITM2 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fitm2 35
  • 88.17 (n)
  • 87.4 (a)
Fitm2 16
Fitm2 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FITM2 35
  • 99.87 (n)
  • 100 (a)
FITM2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fitm2 35
  • 86.77 (n)
  • 86.64 (a)
oppossum
(Monodelphis domestica)
Mammalia FITM2 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FITM2 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves FITM2 35
  • 64.25 (n)
  • 56.49 (a)
FITM2 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FITM2 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fitm2 35
  • 62.18 (n)
  • 55.77 (a)
Str.17485 35
zebrafish
(Danio rerio)
Actinopterygii fitm2 35
  • 56.4 (n)
  • 51.34 (a)
wufc04g08 35
fitm2 36
  • 46 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006131 35
  • 53.86 (n)
  • 33.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10671 35
  • 54.44 (n)
  • 35.24 (a)
CG10671 36
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZK265.9 35
  • 45.99 (n)
  • 32.62 (a)
ZK265.9 36
  • 23 (a)
OneToMany
Species with no ortholog for FITM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FITM2 Gene

ENSEMBL:
Gene Tree for FITM2 (if available)
TreeFam:
Gene Tree for FITM2 (if available)

Paralogs for FITM2 Gene

Paralogs for FITM2 Gene

(1) SIMAP similar genes for FITM2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FITM2: view

Variants for FITM2 Gene

Sequence variations from dbSNP and Humsavar for FITM2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs3746569 -- 44,311,245(+) GCGCA(A/T)GCGCA utr-variant-5-prime
rs4812818 -- 44,310,786(+) AACAC(G/T)AACTG intron-variant
rs6031506 -- 44,312,905(+) CGAAC(G/T)CCTGG upstream-variant-2KB
rs6031507 -- 44,312,988(+) AAACT(C/T)GTTTT upstream-variant-2KB
rs6073401 -- 44,311,110(+) AGCGT(C/T)CCCCG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for FITM2 Gene

Variant ID Type Subtype PubMed ID
nsv3389 CNV Insertion 18451855

Variation tolerance for FITM2 Gene

Residual Variation Intolerance Score: 47.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.16; 39.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FITM2 Gene

HapMap Linkage Disequilibrium report
FITM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FITM2 Gene

Disorders for FITM2 Gene

Relevant External Links for FITM2

Genetic Association Database (GAD)
FITM2
Human Genome Epidemiology (HuGE) Navigator
FITM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FITM2

No disorders were found for FITM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FITM2 Gene

Publications for FITM2 Gene

  1. Evolutionarily conserved gene family important for fat storage. (PMID: 18160536) Kadereit B. … Silver D.L. (Proc. Natl. Acad. Sci. U.S.A. 2008) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. (PMID: 22158537) Cho Y.S. … Seielstad M. (Nat. Genet. 2012) 3
  4. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PMID: 21834987) Bai S.W. … Ridley A.J. (BMC Biol. 2011) 3
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3

Products for FITM2 Gene

Sources for FITM2 Gene

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