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Aliases for FITM2 Gene

Aliases for FITM2 Gene

  • Fat Storage Inducing Transmembrane Protein 2 2 3 5
  • Fat-Inducing Protein 2 3 4
  • C20orf142 3 4
  • Fit2 3 4
  • Fat Storage-Inducing Transmembrane Protein 2 3
  • Chromosome 20 Open Reading Frame 142 2
  • Fat Inducing Transcript 2 2
  • Fat-Inducing Transcript 2 3
  • DJ881L22.2 3

External Ids for FITM2 Gene

Previous HGNC Symbols for FITM2 Gene

  • C20orf142

Previous GeneCards Identifiers for FITM2 Gene

  • GC20M042368
  • GC20M042931

Summaries for FITM2 Gene

Entrez Gene Summary for FITM2 Gene

  • FIT2 belongs to an evolutionarily conserved family of proteins involved in fat storage (Kadereit et al., 2008 [PubMed 18160536]).[supplied by OMIM, May 2008]

GeneCards Summary for FITM2 Gene

FITM2 (Fat Storage Inducing Transmembrane Protein 2) is a Protein Coding gene. Among its related pathways are Metabolism and Lipoprotein metabolism. An important paralog of this gene is FITM1.

UniProtKB/Swiss-Prot for FITM2 Gene

  • Plays an important role in lipid droplet accumulation. Plays a role in the regulation of cell morphology and cytoskeletal organization.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FITM2 Gene

Genomics for FITM2 Gene

Regulatory Elements for FITM2 Gene

Enhancers for FITM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F044173 1.6 FANTOM5 Ensembl ENCODE 13.2 +129.5 129463 15.7 HDGF PKNOX1 MLX YBX1 DMAP1 ZNF48 ZNF121 ZNF302 ZNF207 SMARCA4 JPH2 FITM2 OSER1 SGK2 OSER1-AS1 GC20P044130
GH20F044216 1.4 FANTOM5 Ensembl ENCODE 12.3 +92.4 92411 3.7 ELF3 ARID4B ZNF48 RAD21 ZNF143 DEK MIXL1 THAP11 ZNF654 SP5 OSER1 FITM2 LINC01430 LINC01620 OSER1-AS1 JPH2 GDAP1L1
GH20F044421 1.3 Ensembl ENCODE 11.4 -118.3 -118276 15.2 PKNOX1 ATF1 MLX ARID4B DMAP1 YBX1 YY1 SLC30A9 ZNF143 PAF1 HNF4A LOC105372629 FITM2 LINC01430 LINC01620 PKIG MIR3646
GH20F044206 1.2 ENCODE 12.3 +101.4 101360 6.1 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 OSER1 OSER1-AS1 LINC01728 ENSG00000237555 RPL27AP FITM2 IFT52 JPH2
GH20F044215 1.1 Ensembl ENCODE 12.3 +95.9 95869 0.4 ARID4B ZNF48 ZSCAN9 RAD21 RFX5 ZNF143 MIXL1 THAP11 KLF11 ZNF654 FITM2 OSER1-AS1 OSER1 GDAP1L1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FITM2 on UCSC Golden Path with GeneCards custom track

Promoters for FITM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000119718 349 1800 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143
ENSR00001837644 1548 200 RNF2

Genomic Location for FITM2 Gene

Chromosome:
20
Start:
44,302,838 bp from pter
End:
44,311,249 bp from pter
Size:
8,412 bases
Orientation:
Minus strand

Genomic View for FITM2 Gene

Genes around FITM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FITM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FITM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FITM2 Gene

Proteins for FITM2 Gene

  • Protein details for FITM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6M3-FITM2_HUMAN
    Recommended name:
    Fat storage-inducing transmembrane protein 2
    Protein Accession:
    Q8N6M3
    Secondary Accessions:
    • A1L492
    • B9EGQ4
    • Q5TE59
    • Q9H3Y1

    Protein attributes for FITM2 Gene

    Size:
    262 amino acids
    Molecular mass:
    29855 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FITM2 Gene

Post-translational modifications for FITM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FITM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FITM2 Gene

Domains & Families for FITM2 Gene

Protein Domains for FITM2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FITM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N6M3

UniProtKB/Swiss-Prot:

FITM2_HUMAN :
  • Belongs to the FIT family.
Family:
  • Belongs to the FIT family.
genes like me logo Genes that share domains with FITM2: view

No data available for Gene Families for FITM2 Gene

Function for FITM2 Gene

Molecular function for FITM2 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in lipid droplet accumulation. Plays a role in the regulation of cell morphology and cytoskeletal organization.

Gene Ontology (GO) - Molecular Function for FITM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with FITM2: view
genes like me logo Genes that share phenotypes with FITM2: view

Animal Models for FITM2 Gene

MGI Knock Outs for FITM2:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FITM2 Gene

Localization for FITM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FITM2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FITM2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for FITM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane ISS 18160536
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FITM2: view

Pathways & Interactions for FITM2 Gene

genes like me logo Genes that share pathways with FITM2: view

Pathways by source for FITM2 Gene

Interacting Proteins for FITM2 Gene

Gene Ontology (GO) - Biological Process for FITM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IMP 21834987
GO:0008654 phospholipid biosynthetic process IBA --
GO:0010866 regulation of triglyceride biosynthetic process ISS 18160536
GO:0010890 positive regulation of sequestering of triglyceride ISS 18160536
GO:0019915 lipid storage IBA --
genes like me logo Genes that share ontologies with FITM2: view

No data available for SIGNOR curated interactions for FITM2 Gene

Transcripts for FITM2 Gene

mRNA/cDNA for FITM2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(86) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FITM2 Gene

Fat storage-inducing transmembrane protein 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FITM2 Gene

No ASD Table

Relevant External Links for FITM2 Gene

GeneLoc Exon Structure for
FITM2
ECgene alternative splicing isoforms for
FITM2

Expression for FITM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FITM2 Gene

mRNA differential expression in normal tissues according to GTEx for FITM2 Gene

This gene is overexpressed in Heart - Left Ventricle (x12.2) and Heart - Atrial Appendage (x6.6).

Protein differential expression in normal tissues from HIPED for FITM2 Gene

This gene is overexpressed in Heart (14.7), Liver (7.4), and Retina (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FITM2 Gene



Protein tissue co-expression partners for FITM2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FITM2 Gene:

FITM2

SOURCE GeneReport for Unigene cluster for FITM2 Gene:

Hs.632269

mRNA Expression by UniProt/SwissProt for FITM2 Gene:

Q8N6M3-FITM2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with FITM2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FITM2 Gene

Orthologs for FITM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FITM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FITM2 34 35
  • 99.87 (n)
dog
(Canis familiaris)
Mammalia FITM2 34 35
  • 90.59 (n)
cow
(Bos Taurus)
Mammalia FITM2 34 35
  • 89.95 (n)
mouse
(Mus musculus)
Mammalia Fitm2 34 16 35
  • 88.17 (n)
rat
(Rattus norvegicus)
Mammalia Fitm2 34
  • 86.77 (n)
oppossum
(Monodelphis domestica)
Mammalia FITM2 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FITM2 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves FITM2 34 35
  • 64.25 (n)
lizard
(Anolis carolinensis)
Reptilia FITM2 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fitm2 34
  • 62.18 (n)
Str.17485 34
zebrafish
(Danio rerio)
Actinopterygii fitm2 34 35
  • 56.4 (n)
wufc04g08 34
fruit fly
(Drosophila melanogaster)
Insecta CG10671 34 35
  • 54.44 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006131 34
  • 53.86 (n)
worm
(Caenorhabditis elegans)
Secernentea ZK265.9 34 35
  • 45.99 (n)
Species where no ortholog for FITM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FITM2 Gene

ENSEMBL:
Gene Tree for FITM2 (if available)
TreeFam:
Gene Tree for FITM2 (if available)

Paralogs for FITM2 Gene

Paralogs for FITM2 Gene

(1) SIMAP similar genes for FITM2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FITM2: view

Variants for FITM2 Gene

Sequence variations from dbSNP and Humsavar for FITM2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1062838 -- 44,303,621(-) CTCCA(A/T)AGTGT utr-variant-3-prime
rs111425953 -- 44,312,726(+) CCCCT(C/G)GTTAG upstream-variant-2KB
rs111673353 -- 44,302,743(+) AAATT(A/G)AGAAA downstream-variant-500B
rs112118897 -- 44,311,289(+) GGGCT(C/T)CGGAG upstream-variant-2KB
rs112303907 -- 44,306,494(+) TCAGC(A/G)CCACC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FITM2 Gene

Variant ID Type Subtype PubMed ID
nsv586065 CNV gain 21841781
nsv3389 CNV insertion 18451855
nsv1057847 CNV loss 25217958
esv3645906 CNV gain 21293372

Variation tolerance for FITM2 Gene

Residual Variation Intolerance Score: 47.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.16; 39.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FITM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FITM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FITM2 Gene

Disorders for FITM2 Gene

Relevant External Links for FITM2

Genetic Association Database (GAD)
FITM2
Human Genome Epidemiology (HuGE) Navigator
FITM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FITM2

No disorders were found for FITM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FITM2 Gene

Publications for FITM2 Gene

  1. Evolutionarily conserved gene family important for fat storage. (PMID: 18160536) Kadereit B. … Silver D.L. (Proc. Natl. Acad. Sci. U.S.A. 2008) 2 3 4 64
  2. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. (PMID: 22158537) Cho Y.S. … Seielstad M. (Nat. Genet. 2012) 3 46 64
  3. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PMID: 21834987) Bai S.W. … Ridley A.J. (BMC Biol. 2011) 3 4 64
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for FITM2 Gene

Sources for FITM2 Gene

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