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Aliases for FITM2 Gene

Aliases for FITM2 Gene

  • Fat Storage Inducing Transmembrane Protein 2 2 3 5
  • Fat-Inducing Protein 2 3 4
  • C20orf142 3 4
  • Fit2 3 4
  • Fat Storage-Inducing Transmembrane Protein 2 3
  • Chromosome 20 Open Reading Frame 142 2
  • Fat Inducing Transcript 2 2
  • Fat-Inducing Transcript 2 3
  • DJ881L22.2 3

External Ids for FITM2 Gene

Previous HGNC Symbols for FITM2 Gene

  • C20orf142

Previous GeneCards Identifiers for FITM2 Gene

  • GC20M042368
  • GC20M042931

Summaries for FITM2 Gene

Entrez Gene Summary for FITM2 Gene

  • FIT2 belongs to an evolutionarily conserved family of proteins involved in fat storage (Kadereit et al., 2008 [PubMed 18160536]).[supplied by OMIM, May 2008]

GeneCards Summary for FITM2 Gene

FITM2 (Fat Storage Inducing Transmembrane Protein 2) is a Protein Coding gene. Among its related pathways are Metabolism and Lipoprotein metabolism. An important paralog of this gene is FITM1.

UniProtKB/Swiss-Prot for FITM2 Gene

  • Plays an important role in lipid droplet accumulation. Plays a role in the regulation of cell morphology and cytoskeletal organization.

Additional gene information for FITM2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FITM2 Gene

Genomics for FITM2 Gene

GeneHancer (GH) Regulatory Elements for FITM2 Gene

Promoters and enhancers for FITM2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I044309 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.5 498 2.2 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B FITM2 IFT52 TTPAL GC20M044290
GH20I044173 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.2 +129.5 129463 15.7 HDGF PKNOX1 MLX SIN3A YBX1 DMAP1 ZNF48 TCF12 ZNF121 ZNF302 JPH2 SRSF6 OSER1 L3MBTL1 FITM2 IFT52 SGK2 OSER1-AS1 GC20P044130
GH20I044206 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.3 +101.4 101360 6.1 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 OSER1 OSER1-AS1 SRSF6 FITM2 L3MBTL1 KCNK15 IFT52 WISP2 JPH2
GH20I044397 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 10.6 -98.0 -98006 22.8 HDGF PKNOX1 FOXA2 ARNT MLX ZFP64 ARID4B YBX1 DMAP1 YY1 HNF4A MIR3646 SRSF6 FITM2 LINC01430 LINC01620 SDC4 OSER1-AS1
GH20I044216 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12.3 +92.4 92410 3.7 ELF3 RB1 ZSCAN4 ARID4B ZNF48 RAD21 ARID2 ZNF143 IKZF2 RUNX3 OSER1 SRSF6 FITM2 LINC01430 LINC01620 OSER1-AS1 JPH2 GDAP1L1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FITM2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FITM2 gene promoter:

Genomic Locations for FITM2 Gene

Genomic Locations for FITM2 Gene
chr20:44,302,838-44,311,249
(GRCh38/hg38)
Size:
8,412 bases
Orientation:
Minus strand
chr20:42,931,478-42,939,889
(GRCh37/hg19)

Genomic View for FITM2 Gene

Genes around FITM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FITM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FITM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FITM2 Gene

Proteins for FITM2 Gene

  • Protein details for FITM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6M3-FITM2_HUMAN
    Recommended name:
    Fat storage-inducing transmembrane protein 2
    Protein Accession:
    Q8N6M3
    Secondary Accessions:
    • A1L492
    • B9EGQ4
    • Q5TE59
    • Q9H3Y1

    Protein attributes for FITM2 Gene

    Size:
    262 amino acids
    Molecular mass:
    29855 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FITM2 Gene

Post-translational modifications for FITM2 Gene

No Post-translational modifications

Other Protein References for FITM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FITM2 Gene

Domains & Families for FITM2 Gene

Gene Families for FITM2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for FITM2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FITM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N6M3

UniProtKB/Swiss-Prot:

FITM2_HUMAN :
  • Belongs to the FIT family.
Family:
  • Belongs to the FIT family.
genes like me logo Genes that share domains with FITM2: view

Function for FITM2 Gene

Molecular function for FITM2 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in lipid droplet accumulation. Plays a role in the regulation of cell morphology and cytoskeletal organization.

Phenotypes From GWAS Catalog for FITM2 Gene

Gene Ontology (GO) - Molecular Function for FITM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with FITM2: view
genes like me logo Genes that share phenotypes with FITM2: view

Animal Models for FITM2 Gene

MGI Knock Outs for FITM2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FITM2 Gene

Localization for FITM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FITM2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FITM2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for FITM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS,ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FITM2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FITM2 Gene

Pathways & Interactions for FITM2 Gene

genes like me logo Genes that share pathways with FITM2: view

Pathways by source for FITM2 Gene

Gene Ontology (GO) - Biological Process for FITM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IMP 21834987
GO:0008654 phospholipid biosynthetic process IBA --
GO:0010866 regulation of triglyceride biosynthetic process ISS,IEA 18160536
GO:0010890 positive regulation of sequestering of triglyceride IEA,ISS 18160536
GO:0019915 lipid storage IBA --
genes like me logo Genes that share ontologies with FITM2: view

No data available for SIGNOR curated interactions for FITM2 Gene

Drugs & Compounds for FITM2 Gene

No Compound Related Data Available

Transcripts for FITM2 Gene

mRNA/cDNA for FITM2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(86) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FITM2 Gene

Fat storage-inducing transmembrane protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FITM2 Gene

No ASD Table

Relevant External Links for FITM2 Gene

GeneLoc Exon Structure for
FITM2
ECgene alternative splicing isoforms for
FITM2

Expression for FITM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FITM2 Gene

mRNA differential expression in normal tissues according to GTEx for FITM2 Gene

This gene is overexpressed in Heart - Left Ventricle (x12.2) and Heart - Atrial Appendage (x6.6).

Protein differential expression in normal tissues from HIPED for FITM2 Gene

This gene is overexpressed in Heart (14.7), Liver (7.4), and Retina (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FITM2 Gene



Protein tissue co-expression partners for FITM2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FITM2 Gene:

FITM2

SOURCE GeneReport for Unigene cluster for FITM2 Gene:

Hs.632269

mRNA Expression by UniProt/SwissProt for FITM2 Gene:

Q8N6M3-FITM2_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for FITM2 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with FITM2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FITM2 Gene

Orthologs for FITM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FITM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FITM2 33 34
  • 99.87 (n)
dog
(Canis familiaris)
Mammalia FITM2 33 34
  • 90.59 (n)
cow
(Bos Taurus)
Mammalia FITM2 33 34
  • 89.95 (n)
mouse
(Mus musculus)
Mammalia Fitm2 33 16 34
  • 88.17 (n)
rat
(Rattus norvegicus)
Mammalia Fitm2 33
  • 86.77 (n)
oppossum
(Monodelphis domestica)
Mammalia FITM2 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FITM2 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves FITM2 33 34
  • 64.25 (n)
lizard
(Anolis carolinensis)
Reptilia FITM2 34
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fitm2 33
  • 62.18 (n)
Str.17485 33
zebrafish
(Danio rerio)
Actinopterygii fitm2 33 34
  • 56.4 (n)
wufc04g08 33
fruit fly
(Drosophila melanogaster)
Insecta CG10671 33 34
  • 54.44 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006131 33
  • 53.86 (n)
worm
(Caenorhabditis elegans)
Secernentea ZK265.9 33 34
  • 45.99 (n)
Species where no ortholog for FITM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FITM2 Gene

ENSEMBL:
Gene Tree for FITM2 (if available)
TreeFam:
Gene Tree for FITM2 (if available)

Paralogs for FITM2 Gene

Paralogs for FITM2 Gene

(1) SIMAP similar genes for FITM2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FITM2: view

Variants for FITM2 Gene

Sequence variations from dbSNP and Humsavar for FITM2 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1001218170 -- 44,310,896(-) G/A intron_variant
rs1001380419 -- 44,311,493(-) G/C upstream_transcript_variant
rs1001732944 -- 44,310,642(-) C/T intron_variant
rs1003207520 -- 44,307,857(-) G/T intron_variant
rs1003285104 -- 44,306,182(-) T/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FITM2 Gene

Variant ID Type Subtype PubMed ID
esv3645906 CNV gain 21293372
nsv1057847 CNV loss 25217958
nsv3389 CNV insertion 18451855
nsv586065 CNV gain 21841781

Variation tolerance for FITM2 Gene

Residual Variation Intolerance Score: 47.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.16; 39.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FITM2 Gene

Human Gene Mutation Database (HGMD)
FITM2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FITM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FITM2 Gene

Disorders for FITM2 Gene

Additional Disease Information for FITM2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FITM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FITM2 Gene

Publications for FITM2 Gene

  1. Evolutionarily conserved gene family important for fat storage. (PMID: 18160536) Kadereit B … Silver DL (Proceedings of the National Academy of Sciences of the United States of America 2008) 2 3 4 58
  2. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. (PMID: 22158537) Cho YS … Seielstad M (Nature genetics 2011) 3 44 58
  3. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. (PMID: 21834987) Bai SW … Ridley AJ (BMC biology 2011) 3 4 58
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for FITM2 Gene

Sources for FITM2 Gene

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