FITM2 Gene
protein-coding GIFtS: 40
GCID: GC20M042931
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fat storage-inducing transmembrane protein 2(Previous name: chromosome 20 open reading frame 142 )
(Previous symbol: C20orf142)
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Aliases
for FITM2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fat Storage-Inducing Transmembrane Protein 21 2 | | Chromosome 20 Open Reading Frame 1421 | | C20orf1421 2 3 5 | | Fit22 | | FIT21 3 5 | | Fat Inducing Transcript 22 | | DJ881L22.21 | | Fat-Inducing Transcript 22 | | Fat-Inducing Protein 22 3 | | |
Export aliases for FITM2 gene to outside databasesPrevious GC identifer: GC20M042368 |
Summaries
for FITM2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FITM2:
FIT2 belongs to an evolutionarily conserved family of proteins involved in fat storage (Kadereit et al., 2008 (PubMed18160536)).(supplied by OMIM, May 2008)
UniProtKB/Swiss-Prot: FITM2_HUMAN, Q8N6M3Function: Plays an important role in lipid droplet accumulation. Plays a role in the regulation of cell morphology andcytoskeletal organization
|
Genomic Views
for FITM2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FITM2 gene promoter:
STAT1 Elk-1 Tal-1beta STAT1alpha E47 PPAR-gamma1 ZIC2/Zic2 PPAR-gamma2 Pax-4a ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for FITM2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FITM2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.12 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q13.12FITM2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M042931: view genomic region
(about GC identifiers)
Start:
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42,931,478 bp from pter |
End:
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42,939,889 bp from pter |
Size:
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8,412 bases |
Orientation:
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minus strand |
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Proteins
for FITM2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FITM2_HUMAN, Q8N6M3 (See
protein sequence)Recommended Name: Fat storage-inducing transmembrane protein 2 Size: 262 amino acids; 29855 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Secondary accessions: A1L492 B9EGQ4 Q5TE59 Q9H3Y1Explore the universe of human proteins at neXtProt for FITM2: NX_Q8N6M3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N6M3
FITM2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001073941.1
ENSEMBL proteins: ENSP00000380037
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
FITM2 for ontologies About GeneDecksing
FITM2 Antibody Products:
Assay Products for FITM2: |
Protein
Domains /
Families
for FITM2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FITM2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8N6M3ProtoNet protein and cluster: Q8N6M3 UniProtKB/Swiss-Prot: FITM2_HUMAN, Q8N6M3Similarity: Belongs to the FIT family |
Function
for FITM2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FITM2_HUMAN, Q8N6M3Function: Plays an important role in lipid droplet accumulation. Plays a role in the regulation of cell morphology andcytoskeletal organization
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FITM2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FITM2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FITM2 (NM_006435) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FITM2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FITM2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FITM2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
FITM2 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for FITM2:
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Pathways & Interactions
for FITM2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FITM2
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
FITM2 for ontologies About GeneDecksing
|
Drugs & Compounds
for FITM2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FITM2
Search CenterWatch for drugs/clinical trials and news about FITM2
|
Transcripts
for FITM2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FITM2 gene: NM_001080472.1 Unigene Cluster for FITM2: Fat storage-inducing transmembrane protein 2 Hs.632269 [show with all ESTs]Unigene Representative Sequence: BM4774721 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000396825(uc002xlr.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FITM2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FITM2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FITM2 (NM_006435) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FITM2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FITM2 |
Additional cDNA sequence: BC130446.1 BC136640.1 4 DOTS entries: DT.443703 DT.97785638 DT.100642908 DT.70104274 24/86 AceView cDNA sequences (see all 86): AA401819 AI738442 BM930011 AI052462 BG150125 AW015241 CB243933 AW780201 F10764 BF224391 AI560337 BM671350 BE670979 BM931234 BM692790 BG741109 AI971244 AI242497 CD518403 AI280177 AW952344 F13162 BC029662 BE550875
GeneLoc Exon Structure
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Expression
for FITM2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FITM2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGTGAAGAC
About this image
See FITM2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FITM2
SOURCE GeneReport for Unigene cluster: Hs.632269
UniProtKB/Swiss-Prot: FITM2_HUMAN, Q8N6M3Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for FITM2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FITM2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FITM2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FITM2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FITM2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FITM2 |
Orthologs
for FITM2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FITM2 gene from 7/18 species (see all 18) About this table
ENSEMBL Gene Tree for FITM2 (if available)
TreeFam Gene Tree for FITM2 (if available) |
Paralogs
for FITM2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FITM2 gene
- FITM12
1 SIMAP similar gene for FITM2 using alignment to 1 protein entry: FITM2_HUMAN:FITM1
FITM2 for paralogs About GeneDecksing
|
Genomic Variants
for FITM2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FITM2 (42931478 - 42939889 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FITM2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FITM2 |
|
Disorders
/ Diseases
for FITM2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 FITM2 for disorders About MalaCards
FITM2 for disorders About GeneDecksing
OMIM gene information: 612029
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: FITM2 (1 document)
Export disorders for FITM2 gene to outside databases
|
Publications
for FITM2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FITM2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FITM2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Evolutionarily conserved gene family important for fat storage. (PubMed id 18160536)1, 2, 3 Kadereit B....Silver D.L. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Meta-analysis of genome-wide association studies ident ifies eight new loci for type 2 diabetes in east Asians. (PubMed id 22158537)1 Cho Y.S....Seielstad M. (2012)
- Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PubMed id 21834987)2 Bai S.W.... Ridley A.J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for FITM2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing FITM2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FITM2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FITM2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FITM2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for FITM2 gene:
Search GeneIP for patents involving FITM2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FITM2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FITM2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FITM2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FITM2 | | OriGene 3'-UTR Clone for FITM2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FITM2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FITM2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FITM2 | | OriGene Custom Protein Services for FITM2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FITM2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FITM2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FITM2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FITM2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FITM2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FITM2 |
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 |  |  |  | |
| | | | Search Tocris compounds for FITM2 |
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 | | | FITM2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FITM2 |
|  |  |  | | | | Search ThermoFisher Antibodies for FITM2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FITM2 |
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