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Aliases for FITM1 Gene

Aliases for FITM1 Gene

  • Fat Storage Inducing Transmembrane Protein 1 2 3 5
  • Fat-Inducing Transcript 1 2 3
  • Fat-Inducing Protein 1 3 4
  • FIT1 3 4
  • Fat Storage-Inducing Transmembrane Protein 1 3

External Ids for FITM1 Gene

Previous GeneCards Identifiers for FITM1 Gene

  • GC14P023672
  • GC14P024600
  • GC14P004715

Summaries for FITM1 Gene

Entrez Gene Summary for FITM1 Gene

  • FIT1 belongs to an evolutionarily conserved family of proteins involved in fat storage (Kadereit et al., 2008 [PubMed 18160536]).[supplied by OMIM, May 2008]

GeneCards Summary for FITM1 Gene

FITM1 (Fat Storage Inducing Transmembrane Protein 1) is a Protein Coding gene. Among its related pathways are Metabolism and Lipoprotein metabolism. An important paralog of this gene is FITM2.

UniProtKB/Swiss-Prot for FITM1 Gene

  • Plays an important role in lipid droplet accumulation.

Additional gene information for FITM1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FITM1 Gene

Genomics for FITM1 Gene

GeneHancer (GH) Regulatory Elements for FITM1 Gene

Promoters and enhancers for FITM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I024130 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 550.8 +0.5 501 3.2 ELF3 NFIB ARID4B SIN3A DMAP1 ZNF48 RARA YY1 SLC30A9 CREM FITM1 EMC9 PSME1 ENSG00000259371
GH14I024108 Enhancer 1.2 Ensembl ENCODE 11.3 -22.4 -22417 1.5 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 EMC9 CPNE6 CARMIL3 FITM1 PSME1 IRF9 RNF31 PSME2 TM9SF1 ENSG00000254692
GH14I024106 Enhancer 0.7 Ensembl 11.3 -25.0 -24974 0.2 ELF3 ARID4B THRB RAD21 RARA TEAD3 POLR2A NR2F6 MAFK PAF1 CPNE6 CARMIL3 FITM1 PSME1 IRF9 EMC9 RNF31 PSME2 TM9SF1 ENSG00000254692
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FITM1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FITM1 gene promoter:

Genomic Locations for FITM1 Gene

Genomic Locations for FITM1 Gene
chr14:24,131,275-24,132,849
(GRCh38/hg38)
Size:
1,575 bases
Orientation:
Plus strand
chr14:24,600,484-24,602,058
(GRCh37/hg19)

Genomic View for FITM1 Gene

Genes around FITM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FITM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FITM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FITM1 Gene

Proteins for FITM1 Gene

  • Protein details for FITM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A5D6W6-FITM1_HUMAN
    Recommended name:
    Fat storage-inducing transmembrane protein 1
    Protein Accession:
    A5D6W6
    Secondary Accessions:
    • Q8IUQ7

    Protein attributes for FITM1 Gene

    Size:
    292 amino acids
    Molecular mass:
    32207 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FITM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FITM1 Gene

Post-translational modifications for FITM1 Gene

No Post-translational modifications

Other Protein References for FITM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FITM1 Gene

Domains & Families for FITM1 Gene

Gene Families for FITM1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for FITM1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FITM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A5D6W6

UniProtKB/Swiss-Prot:

FITM1_HUMAN :
  • Belongs to the FIT family.
Family:
  • Belongs to the FIT family.
genes like me logo Genes that share domains with FITM1: view

Function for FITM1 Gene

Molecular function for FITM1 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in lipid droplet accumulation.

Gene Ontology (GO) - Molecular Function for FITM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with FITM1: view
genes like me logo Genes that share phenotypes with FITM1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FITM1 Gene

Localization for FITM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FITM1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FITM1 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for FITM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane ISS,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030176 integral component of endoplasmic reticulum membrane IBA --
genes like me logo Genes that share ontologies with FITM1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FITM1 Gene

Pathways & Interactions for FITM1 Gene

genes like me logo Genes that share pathways with FITM1: view

Pathways by source for FITM1 Gene

Interacting Proteins for FITM1 Gene

Gene Ontology (GO) - Biological Process for FITM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008654 phospholipid biosynthetic process IBA --
GO:0010890 positive regulation of sequestering of triglyceride ISS 18160536
GO:0019915 lipid storage IBA --
GO:0034389 lipid particle organization TAS --
genes like me logo Genes that share ontologies with FITM1: view

No data available for SIGNOR curated interactions for FITM1 Gene

Drugs & Compounds for FITM1 Gene

No Compound Related Data Available

Transcripts for FITM1 Gene

mRNA/cDNA for FITM1 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(382) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FITM1 Gene

Fat storage-inducing transmembrane protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FITM1 Gene

No ASD Table

Relevant External Links for FITM1 Gene

GeneLoc Exon Structure for
FITM1
ECgene alternative splicing isoforms for
FITM1

Expression for FITM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FITM1 Gene

mRNA differential expression in normal tissues according to GTEx for FITM1 Gene

This gene is overexpressed in Muscle - Skeletal (x17.3), Heart - Left Ventricle (x14.6), and Heart - Atrial Appendage (x10.8).

Protein differential expression in normal tissues from HIPED for FITM1 Gene

This gene is overexpressed in Bone (26.3), Liver (22.1), and Heart (20.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FITM1 Gene



Protein tissue co-expression partners for FITM1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FITM1 Gene:

FITM1

SOURCE GeneReport for Unigene cluster for FITM1 Gene:

Hs.128060

mRNA Expression by UniProt/SwissProt for FITM1 Gene:

A5D6W6-FITM1_HUMAN
Tissue specificity: Primarily expressed in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for FITM1 Gene

  • Pancreas(4.2)
  • Muscle(3.7)
  • Heart(2.6)
genes like me logo Genes that share expression patterns with FITM1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FITM1 Gene

Orthologs for FITM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FITM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FITM1 33 34
  • 98.74 (n)
dog
(Canis familiaris)
Mammalia FITM1 33 34
  • 93.49 (n)
cow
(Bos Taurus)
Mammalia FITM1 33 34
  • 93.15 (n)
mouse
(Mus musculus)
Mammalia Fitm1 33 16 34
  • 88.7 (n)
rat
(Rattus norvegicus)
Mammalia Fitm1 33
  • 88.01 (n)
oppossum
(Monodelphis domestica)
Mammalia FITM1 34
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FITM1 34
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FITM1 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fitm1 33
  • 58.08 (n)
zebrafish
(Danio rerio)
Actinopterygii fitm1 33 34
  • 53.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10671 34
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZK265.9 34
  • 21 (a)
OneToMany
Species where no ortholog for FITM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FITM1 Gene

ENSEMBL:
Gene Tree for FITM1 (if available)
TreeFam:
Gene Tree for FITM1 (if available)

Paralogs for FITM1 Gene

Paralogs for FITM1 Gene

(1) SIMAP similar genes for FITM1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FITM1: view

Variants for FITM1 Gene

Sequence variations from dbSNP and Humsavar for FITM1 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000129518 -- 24,132,653(+) C/G coding_sequence_variant, missense_variant
rs1001389846 -- 24,130,009(+) AAAAAAA/AAAAAAAA upstream_transcript_variant
rs1004289036 -- 24,131,675(+) TTT/TT coding_sequence_variant, frameshift
rs1004838199 -- 24,130,759(+) A/G upstream_transcript_variant
rs1004904112 -- 24,132,108(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FITM1 Gene

Variant ID Type Subtype PubMed ID
nsv564057 CNV loss 21841781

Variation tolerance for FITM1 Gene

Residual Variation Intolerance Score: 69.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FITM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FITM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FITM1 Gene

Disorders for FITM1 Gene

Additional Disease Information for FITM1

No disorders were found for FITM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FITM1 Gene

Publications for FITM1 Gene

  1. Evolutionarily conserved gene family important for fat storage. (PMID: 18160536) Kadereit B … Silver DL (Proceedings of the National Academy of Sciences of the United States of America 2008) 2 3 4 58
  2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for FITM1 Gene

Sources for FITM1 Gene

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