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Aliases for FITM1 Gene

Aliases for FITM1 Gene

  • Fat Storage-Inducing Transmembrane Protein 1 2 3
  • FIT1 3 4 6
  • Fat-Inducing Transcript 1 2 3
  • Fat-Inducing Protein 1 3 4

External Ids for FITM1 Gene

Summaries for FITM1 Gene

Entrez Gene Summary for FITM1 Gene

  • FIT1 belongs to an evolutionarily conserved family of proteins involved in fat storage (Kadereit et al., 2008 [PubMed 18160536]).[supplied by OMIM, May 2008]

GeneCards Summary for FITM1 Gene

FITM1 (Fat Storage-Inducing Transmembrane Protein 1) is a Protein Coding gene. An important paralog of this gene is FITM2.

UniProtKB/Swiss-Prot for FITM1 Gene

  • Plays an important role in lipid droplet accumulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FITM1 Gene

Genomics for FITM1 Gene

Genomic Location for FITM1 Gene

Start:
24,131,275 bp from pter
End:
24,132,849 bp from pter
Size:
1,575 bases
Orientation:
Plus strand

Genomic View for FITM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FITM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FITM1 Gene

Regulatory Elements for FITM1 Gene

Proteins for FITM1 Gene

  • Protein details for FITM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A5D6W6-FITM1_HUMAN
    Recommended name:
    Fat storage-inducing transmembrane protein 1
    Protein Accession:
    A5D6W6
    Secondary Accessions:
    • Q8IUQ7

    Protein attributes for FITM1 Gene

    Size:
    292 amino acids
    Molecular mass:
    32207 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FITM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FITM1 Gene

Proteomics data for FITM1 Gene at MOPED

Post-translational modifications for FITM1 Gene

No Post-translational modifications

Other Protein References for FITM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FITM1 Gene

Domains for FITM1 Gene

Protein Domains for FITM1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

FITM1_HUMAN
Family:
  • Belongs to the FIT family.:
    • A5D6W6
genes like me logo Genes that share domains with FITM1: view

No data available for Gene Families for FITM1 Gene

Function for FITM1 Gene

Molecular function for FITM1 Gene

UniProtKB/Swiss-Prot Function: Plays an important role in lipid droplet accumulation.

Gene Ontology (GO) - Molecular Function for FITM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with FITM1: view

Phenotypes for FITM1 Gene

GenomeRNAi human phenotypes for FITM1:
genes like me logo Genes that share phenotypes with FITM1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FITM1 Gene

Localization for FITM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FITM1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FITM1 Gene COMPARTMENTS Subcellular localization image for FITM1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for FITM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane ISS 18160536
GO:0030176 integral component of endoplasmic reticulum membrane IBA --
genes like me logo Genes that share ontologies with FITM1: view

Pathways for FITM1 Gene

SuperPathways for FITM1 Gene

No Data Available

Interacting Proteins for FITM1 Gene

Gene Ontology (GO) - Biological Process for FITM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008654 phospholipid biosynthetic process IBA --
GO:0010890 positive regulation of sequestering of triglyceride ISS 18160536
GO:0019915 lipid storage IBA --
GO:0034389 lipid particle organization ISS 18160536
genes like me logo Genes that share ontologies with FITM1: view

No data available for Pathways by source for FITM1 Gene

Transcripts for FITM1 Gene

mRNA/cDNA for FITM1 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(382) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FITM1 Gene

Fat storage-inducing transmembrane protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FITM1 Gene

No ASD Table

Relevant External Links for FITM1 Gene

GeneLoc Exon Structure for
FITM1
ECgene alternative splicing isoforms for
FITM1

Expression for FITM1 Gene

mRNA expression in normal human tissues for FITM1 Gene

mRNA differential expression in normal tissues according to GTEx for FITM1 Gene

This gene is overexpressed in Muscle - Skeletal (17.3), Heart - Left Ventricle (14.6), and Heart - Atrial Appendage (10.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FITM1 Gene

SOURCE GeneReport for Unigene cluster for FITM1 Gene Hs.128060

mRNA Expression by UniProt/SwissProt for FITM1 Gene

A5D6W6-FITM1_HUMAN
Tissue specificity: Primarily expressed in heart and skeletal muscle.
genes like me logo Genes that share expressions with FITM1: view

Orthologs for FITM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FITM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FITM1 36
  • 98.74 (n)
  • 98.29 (a)
FITM1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FITM1 36
  • 93.15 (n)
  • 97.6 (a)
FITM1 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FITM1 36
  • 93.49 (n)
  • 98.63 (a)
FITM1 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fitm1 36
  • 88.7 (n)
  • 96.23 (a)
Fitm1 16
Fitm1 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FITM1 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FITM1 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fitm1 36
  • 88.01 (n)
  • 95.55 (a)
lizard
(Anolis carolinensis)
Reptilia FITM1 37
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fitm1 36
  • 58.08 (n)
  • 58.08 (a)
zebrafish
(Danio rerio)
Actinopterygii fitm1 36
  • 53.33 (n)
  • 44.8 (a)
fitm1 37
  • 38 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10671 37
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZK265.9 37
  • 21 (a)
OneToMany
Species with no ortholog for FITM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FITM1 Gene

ENSEMBL:
Gene Tree for FITM1 (if available)
TreeFam:
Gene Tree for FITM1 (if available)

Paralogs for FITM1 Gene

Paralogs for FITM1 Gene

Selected SIMAP similar genes for FITM1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FITM1: view

Variants for FITM1 Gene

Sequence variations from dbSNP and Humsavar for FITM1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs762090 -- 24,131,607(-) TTCGG(A/C/G)ccccc reference, missense
rs762091 -- 24,131,601(-) ccccc(C/G)ccccc frameshift-variant
rs762092 -- 24,131,568(-) cccgc(C/T)ccatg reference, missense
rs927494 -- 24,131,181(-) AGGGA(A/T)ATCAG upstream-variant-2KB
rs6573572 -- 24,130,021(+) taaat(A/C)ataaa upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FITM1 Gene

Variant ID Type Subtype PubMed ID
nsv901498 CNV Loss 21882294

Relevant External Links for FITM1 Gene

HapMap Linkage Disequilibrium report
FITM1

Disorders for FITM1 Gene

No disorders were found for FITM1 Gene.

No data available for UniProtKB/Swiss-Prot for FITM1 Gene

Publications for FITM1 Gene

  1. Evolutionarily conserved gene family important for fat storage. (PMID: 18160536) Kadereit B. … Silver D.L. (Proc. Natl. Acad. Sci. U.S.A. 2008) 2 3 4
  2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FITM1 Gene

Sources for FITM1 Gene

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